perhexiline has been researched along with Breast Neoplasms in 3 studies
Perhexiline: 2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An adriamycin-resistant human breast cancer cell line (MCF 7Ad) was developed by exposing the parent line (MCF 7) to gradually increasing concentrations of adriamycin while the cells were being grown in monolayer." | 5.27 | Modulation of induced resistance to adriamycin in two human breast cancer cell lines with tamoxifen or perhexiline maleate. ( Foster, BJ; Grotzinger, KR; Hamilton, TC; McKoy, WM; Rubinstein, LV, 1988) |
| " The novel approach used here led to the discovery that perhexiline ablates HER3 expression, and offers an opportunity to identify HER3 ablation modulators as innovative therapeutics to improve survival in breast cancer patients." | 3.81 | Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth. ( Barak, LS; Chen, W; Lyerly, HK; Mook, RA; Morse, MA; Osada, T; Ren, XR; Wang, J, 2015) |
| "An adriamycin-resistant human breast cancer cell line (MCF 7Ad) was developed by exposing the parent line (MCF 7) to gradually increasing concentrations of adriamycin while the cells were being grown in monolayer." | 1.27 | Modulation of induced resistance to adriamycin in two human breast cancer cell lines with tamoxifen or perhexiline maleate. ( Foster, BJ; Grotzinger, KR; Hamilton, TC; McKoy, WM; Rubinstein, LV, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stäubert, C | 1 |
| Broom, OJ | 1 |
| Nordström, A | 1 |
| Ren, XR | 1 |
| Wang, J | 1 |
| Osada, T | 1 |
| Mook, RA | 1 |
| Morse, MA | 1 |
| Barak, LS | 1 |
| Lyerly, HK | 1 |
| Chen, W | 1 |
| Foster, BJ | 1 |
| Grotzinger, KR | 1 |
| McKoy, WM | 1 |
| Rubinstein, LV | 1 |
| Hamilton, TC | 1 |
3 other studies available for perhexiline and Breast Neoplasms
| Article | Year |
|---|---|
Hydroxycarboxylic acid receptors are essential for breast cancer cells to control their lipid/fatty acid metabolism.
Topics: Breast Neoplasms; Carnitine O-Palmitoyltransferase; Cell Death; Cell Line, Tumor; Cell Proliferation | 2015 |
Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Membrane; Cell Proliferatio | 2015 |
Modulation of induced resistance to adriamycin in two human breast cancer cell lines with tamoxifen or perhexiline maleate.
Topics: Breast Neoplasms; Cell Line; Doxorubicin; Drug Interactions; Drug Resistance; Fluorouracil; Humans; | 1988 |