perhexiline has been researched along with Angina Pectoris in 164 studies
Perhexiline: 2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
Angina Pectoris: The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine whether the prophylactic antianginal agent perhexiline potentiates platelet responsiveness to nitric oxide (NO) in patients with stable angina pectoris (SAP) and acute coronary syndromes (ACS: unstable angina pectoris or non-Q-wave myocardial infarction)." | 9.10 | Beneficial clinical effects of perhexiline in patients with stable angina pectoris and acute coronary syndromes are associated with potentiation of platelet responsiveness to nitric oxide. ( Chirkov, YY; Holmes, AS; Horowitz, JD; Kennedy, JA; Stewart, S; Willoughby, SR, 2002) |
| "A random single-blind study of oxprenolol against perhexiline has been undertaken in angina pectoris." | 9.04 | Comparative trial of perhexiline maleate and oxprenolol in patients with angina pectoris. ( Pilcher, J, 1978) |
| "Perhexiline maleate, which has no beta adreno-receptor-blocking activity, has been suggested as an effective prophylactic agent for angina pectoris." | 9.04 | A double-blind trial of perhexiline maleate in the prophylaxis of angina pectoris. ( Brown, MJ; Horowitz, JD; Mashford, ML, 1976) |
| "The antianginal effect of perhexiline was evaluated in a placebo-controlled double-blind study of 20 patients with stable angina pectoris." | 9.04 | [Clinical efficacy of perhexiline maleate in stable angina pectoris (author's transl)]. ( Glogar, D; Linkesch, W; Niederberger, M, 1978) |
| "Perhexiline maleate, which causes inhibition of myocardial fatty acid catabolism with a concomitant increase in glucose utilization, is particularly useful in the management of patients with severe angina pectoris." | 7.67 | Perhexiline maleate treatment for severe angina pectoris--correlations with pharmacokinetics. ( Goble, AJ; Horowitz, JD; Louis, WJ; Macdonald, PS; Sia, ST, 1986) |
| "A five-year personal experience of the use of perhexiline maleate (Pexid) in the treatment of severe angina pectoris is presented." | 7.66 | Perhexiline maleate in the treatment of angina pectoris. Five years of personal clinical experience. ( Wallace, DC, 1978) |
| "Perhexiline maleate was used as a prophylactic agent in 26 patients suffering from severe angina pectoris." | 7.66 | Perhexiline maleate in the treatment of severe angina pectoris. ( Horowitz, JD; Mashford, ML, 1979) |
| " In this study, dose requirement declined with age in a frail and wasting population as a result of weight-related pharmacokinetic factors." | 5.37 | Effects of aging, renal dysfunction, left ventricular systolic impairment, and weight on steady state pharmacokinetics of perhexiline. ( Averbuj, P; Chik, W; Horowitz, JD; Ling, LH; Morris, RG; Ngo, DT; Pati, PK; Sallustio, BC; Sverdlov, AL, 2011) |
| "Perhexiline maleate is an agent currently under investigation in Canada that is used for angina unresponsive to other treatment." | 5.26 | Papilledema without peripheral neuropathy in a patient taking perhexiline maleate. ( Colman, J; Mandelcorn, M; Murphy, J, 1982) |
| "To examine whether the prophylactic antianginal agent perhexiline potentiates platelet responsiveness to nitric oxide (NO) in patients with stable angina pectoris (SAP) and acute coronary syndromes (ACS: unstable angina pectoris or non-Q-wave myocardial infarction)." | 5.10 | Beneficial clinical effects of perhexiline in patients with stable angina pectoris and acute coronary syndromes are associated with potentiation of platelet responsiveness to nitric oxide. ( Chirkov, YY; Holmes, AS; Horowitz, JD; Kennedy, JA; Stewart, S; Willoughby, SR, 2002) |
| "A random single-blind study of oxprenolol against perhexiline has been undertaken in angina pectoris." | 5.04 | Comparative trial of perhexiline maleate and oxprenolol in patients with angina pectoris. ( Pilcher, J, 1978) |
| "Perhexiline maleate, which has no beta adreno-receptor-blocking activity, has been suggested as an effective prophylactic agent for angina pectoris." | 5.04 | A double-blind trial of perhexiline maleate in the prophylaxis of angina pectoris. ( Brown, MJ; Horowitz, JD; Mashford, ML, 1976) |
| "The antianginal effect of perhexiline was evaluated in a placebo-controlled double-blind study of 20 patients with stable angina pectoris." | 5.04 | [Clinical efficacy of perhexiline maleate in stable angina pectoris (author's transl)]. ( Glogar, D; Linkesch, W; Niederberger, M, 1978) |
| "Perhexiline was introduced about 30 years ago and rapidly gained a reputation for efficacy in the management of angina pectoris." | 4.81 | Systematic review of the efficacy and safety of perhexiline in the treatment of ischemic heart disease. ( Killalea, SM; Krum, H, 2001) |
| "Eight blood samples were taken over a 24-h period from 12 adult patients already taking perhexiline for the treatment of angina pectoris." | 3.72 | Concentration-time profile for perhexiline and hydroxyperhexiline in patients at steady state. ( Horowitz, JD; Jones, TE; Morris, RG, 2004) |
| "Experience is reported with 41 patients taking perhexiline maleate for angina pectoris for periods of up to 70 months, while serum concentrations of the drug were monitored, and liver function tests and electromyographic tests were made before and during treatment." | 3.67 | Investigations of long-term treatment with perhexiline maleate using therapeutic monitoring and electromyography. ( Cooper, JD; Lockhart, JD; Matenga, J; Paul, R; Pilcher, J; Turnell, DC, 1985) |
| "Perhexiline maleate, which causes inhibition of myocardial fatty acid catabolism with a concomitant increase in glucose utilization, is particularly useful in the management of patients with severe angina pectoris." | 3.67 | Perhexiline maleate treatment for severe angina pectoris--correlations with pharmacokinetics. ( Goble, AJ; Horowitz, JD; Louis, WJ; Macdonald, PS; Sia, ST, 1986) |
| "We performed a double-blind controlled crossover trial of perhexiline maleate versus identical placebo in daily doses of 100-400 mg in 20 male patients who were severely limited with angina pectoris despite therapy with beta-adrenoreceptor blockers." | 3.66 | Antianginal efficacy of perhexiline maleate in patients refractory to beta-adrenoreceptor blockade. ( Lowe, JB; White, HD, 1983) |
| "In a 78-year-old woman receiving perhexiline maleate for intractable angina pectoris, a syndrome of parkinsonism and peripheral neuropathy developed." | 3.66 | Perhexiline maleate as a cause of reversible parkinsonism and peripheral neuropathy. ( Gordon, AS; Gordon, M, 1981) |
| "Five patients developed a mild to severe polyneuropathy while under treatment with perhexiline maleate, a drug used in long-term treatment of angina pectoris." | 3.66 | Perhexiline neuropathy: a clinicopathological study. ( Said, G, 1978) |
| "The authors report the cases of 2 patients who died from cirrhosis after receiving perhexiline maleate, a drug widely used in Europe for the treatment of angina pectoris." | 3.66 | Perhexiline maleate-induced cirrhosis. ( Benhamou, JP; Bichara, M; Degott, C; Feldmann, G; Pessayre, D; Potet, F, 1979) |
| "Peripheral neuropathy has been noted as a complication of therapy with perhexiline maleate, a drug widely used in France (and in clinical trials in the United States) for the prophylactic treatment of angina pectoris." | 3.66 | Perhexiline maleate and peripheral neuropathy. ( Bouche, P; Bousser, MG; Cathala, HP; Peytour, MA, 1979) |
| " Perhexiline maleate controlled his symptoms but when the drug was stopped because of side effects an acute inferior myocardial infarction occurred." | 3.66 | Recurrence of Prinzmetal angina seven years following aortocoronary bypass surgery: a clinical and angiographic follow-up. ( Crittin, J; Lespérance, J; Mizgala, HF; Théroux, P; Waters, DD, 1979) |
| "A five-year personal experience of the use of perhexiline maleate (Pexid) in the treatment of severe angina pectoris is presented." | 3.66 | Perhexiline maleate in the treatment of angina pectoris. Five years of personal clinical experience. ( Wallace, DC, 1978) |
| "Perhexiline maleate was used as a prophylactic agent in 26 patients suffering from severe angina pectoris." | 3.66 | Perhexiline maleate in the treatment of severe angina pectoris. ( Horowitz, JD; Mashford, ML, 1979) |
| "Perhexiline maleate (Pexid) which has been in general use in France with good results for the treatment of angina pectoris since 1973, may be associated with severe side effects including peripheral neuropathy." | 3.66 | Pharmacokinetics of perhexiline maleate in anginal patients with and without peripheral neuropathy. ( Goujet, MA; Simon, P; Singlas, E, 1978) |
| "In the face of the recent introduction of beta-blockers and calcium inhibitors, the author examines the role of Amiodarone, Perhexiline and Molsidomine in the treatment of angina pectoris." | 3.66 | [The classic anti-anginal agents and molsidomine]. ( Vacheron, A, 1983) |
| "The pathological findings in four nerves and muscles and in one skin biopsies from four patients treated with perhexiline maleate for angina pectoris are reported." | 3.65 | [Electron microscopic study of nerve, muscle and skin lesions induced by perhexiline maleate (author's transl)]. ( Escourolle, R; Hauw, JJ; Mussini, JM, 1977) |
| "Perhexiline is an antianginal agent that displays both saturable and polymorphic metabolism via CYP2D6." | 2.71 | Clinical inhibition of CYP2D6-catalysed metabolism by the antianginal agent perhexiline. ( Coller, JK; Davies, BJ; Gillis, D; Horowitz, JD; James, HM; Morris, RG; Sallustio, BC; Somogyi, AA, 2004) |
| " With attention to the pharmacokinetics of perhexiline's elimination in individual patients, this novel antianginal agent seems to be safe and effective and deserves further evaluation in patients already receiving maximal antianginal therapy who are not candidates for revascularization procedures." | 2.67 | Efficacy and safety of perhexiline maleate in refractory angina. A double-blind placebo-controlled clinical trial of a novel antianginal agent. ( Antman, EM; Beamer, AD; Benfell, K; Cantillon, CO; Cole, PL; Hartley, LH; Kelly, RA; McGowan, N; Smith, TW, 1990) |
| " In this study, dose requirement declined with age in a frail and wasting population as a result of weight-related pharmacokinetic factors." | 1.37 | Effects of aging, renal dysfunction, left ventricular systolic impairment, and weight on steady state pharmacokinetics of perhexiline. ( Averbuj, P; Chik, W; Horowitz, JD; Ling, LH; Morris, RG; Ngo, DT; Pati, PK; Sallustio, BC; Sverdlov, AL, 2011) |
| " 2) To determine whether the ratio measured in the first fortnight of treatment (C(i)(OHPx)/C(i)(Px)) may be used to guide patient dosing with perhexiline, a drug with a narrow therapeutic index, long half-life and saturable metabolism via CYP2D6." | 1.31 | Pharmacokinetics of the antianginal agent perhexiline: relationship between metabolic ratio and steady-state dose. ( Morris, RG; Sallustio, BC; Westley, IS, 2002) |
| "Perhexiline is a prophylactic antianginal agent particularly useful in patients whose angina is poorly controlled or refractory to conventional drug regimens." | 1.30 | Assessment of interlaboratory performance in the provision of perhexiline therapeutic drug monitoring services in Australia. ( Morris, RG; Sallustio, BC, 1999) |
| "We report on a case of perhexiline maleate-induced hepatitis secondary to a long-term administration of recommended daily dosages of 300 mg." | 1.28 | Perhexiline maleate-induced hepatitis. ( Maurer, R; Satz, N; Spycher, MA; Streuli, R; Täuber, M, 1991) |
| "Perhexiline maleate is a potent anti-anginal drug which may cause alcoholic-type hepatitis and cirrhosis." | 1.27 | Perhexiline maleate induced cirrhosis. ( Dunn, D; Pieterse, AS; Rowland, R, 1983) |
| "Perhexiline maleate is an antianginal agent which depends on hepatic oxidation for its elimination." | 1.27 | Impaired oxidation of debrisoquine in patients with perhexiline liver injury. ( Morgan, MY; Oates, NS; Reshef, R; Shah, RR; Sherlock, S; Smith, RL, 1984) |
| "Nifedipine was effective in all 5 cases with coronary stenosis of more than 75." | 1.26 | Effects of calcium antagonists, especially nifedipine, on variant angina, resting angina, and unstable angina. ( Hayakawa, H; Kimura, E; Kishida, H; Kusama, Y; Otsu, F; Takayama, M, 1982) |
| "Perhexiline maleate is an agent currently under investigation in Canada that is used for angina unresponsive to other treatment." | 1.26 | Papilledema without peripheral neuropathy in a patient taking perhexiline maleate. ( Colman, J; Mandelcorn, M; Murphy, J, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 145 (88.41) | 18.7374 |
| 1990's | 5 (3.05) | 18.2507 |
| 2000's | 12 (7.32) | 29.6817 |
| 2010's | 2 (1.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chong, CR | 1 |
| Sallustio, B | 1 |
| Horowitz, JD | 13 |
| Jawad, E | 1 |
| Arora, R | 1 |
| Phan, TT | 1 |
| Shivu, GN | 1 |
| Choudhury, A | 1 |
| Abozguia, K | 1 |
| Davies, C | 1 |
| Naidoo, U | 1 |
| Ahmed, I | 1 |
| Yousef, Z | 1 |
| Horowitz, J | 2 |
| Frenneaux, M | 2 |
| Ling, LH | 1 |
| Chik, W | 1 |
| Averbuj, P | 1 |
| Pati, PK | 1 |
| Sverdlov, AL | 1 |
| Ngo, DT | 1 |
| Morris, RG | 5 |
| Sallustio, BC | 4 |
| Westley, IS | 1 |
| Willoughby, SR | 2 |
| Stewart, S | 2 |
| Chirkov, YY | 1 |
| Kennedy, JA | 3 |
| Holmes, AS | 1 |
| Killalea, SM | 1 |
| Krum, H | 1 |
| Jones, TE | 1 |
| Davies, BJ | 1 |
| Coller, JK | 1 |
| James, HM | 1 |
| Gillis, D | 1 |
| Somogyi, AA | 1 |
| Lee, L | 1 |
| Beck-Oldach, K | 1 |
| McFadden-Lewis, K | 1 |
| Murphy, GA | 1 |
| Wong, YW | 1 |
| Zhang, Y | 1 |
| Inglis, S | 1 |
| Liberts, EA | 1 |
| Ashrafian, H | 1 |
| Frenneaux, MP | 1 |
| Opie, LH | 1 |
| Heathfield, KW | 1 |
| Carabott, F | 1 |
| Dawes, P | 1 |
| Moulder, C | 1 |
| Nicolas, G | 1 |
| Bouhour, JB | 1 |
| Godin, JF | 1 |
| White, HD | 1 |
| Lowe, JB | 1 |
| Gordon, M | 1 |
| Gordon, AS | 1 |
| Shah, RR | 3 |
| Oates, NS | 3 |
| Idle, JR | 2 |
| Smith, RL | 3 |
| Lockhart, JD | 5 |
| Lorentz, IT | 1 |
| Shortall, M | 1 |
| Maclean, D | 1 |
| Feely, J | 1 |
| Vacheron, A | 1 |
| Morgan, MY | 1 |
| Reshef, R | 1 |
| Sherlock, S | 1 |
| Hopf, R | 1 |
| Becker, HJ | 1 |
| Kober, G | 1 |
| Dowinsky, S | 1 |
| Kaltenbach, M | 1 |
| Dipalma, JR | 1 |
| Rees, JR | 5 |
| Pieterse, AS | 1 |
| Rowland, R | 1 |
| Dunn, D | 1 |
| Ikram, H | 4 |
| Maslowski, AH | 1 |
| Mandelcorn, M | 1 |
| Murphy, J | 1 |
| Colman, J | 1 |
| Kishida, H | 1 |
| Otsu, F | 1 |
| Kusama, Y | 1 |
| Takayama, M | 1 |
| Hayakawa, H | 1 |
| Kimura, E | 1 |
| Nayler, WG | 1 |
| Flaim, SF | 1 |
| Zelis, R | 1 |
| Roberts, RK | 1 |
| Cohn, D | 1 |
| Petroff, V | 1 |
| Seneviratne, B | 1 |
| Lancelin, B | 1 |
| Blanchard, D | 1 |
| Aziza, JP | 1 |
| Guermonprez, JL | 1 |
| Maurice, P | 1 |
| Poupon, R | 1 |
| Rosensztajn, L | 1 |
| Prudhomme de Saint-Maur, P | 1 |
| Lageron, A | 1 |
| Gombeau, T | 1 |
| Darnis, F | 1 |
| Atkinson, AB | 1 |
| McAreavey, D | 1 |
| Trope, G | 1 |
| Caruzzo, C | 1 |
| Troni, W | 1 |
| Cremo, R | 1 |
| Long, JP | 1 |
| Fitzgerald, O | 1 |
| Maurer, BJ | 1 |
| Button, IK | 1 |
| Wing, L | 1 |
| Siebert, WJ | 1 |
| Gabb, GM | 1 |
| Wing, LM | 1 |
| Rivier, JL | 1 |
| Short, D | 2 |
| Wallace, DC | 2 |
| Santos Rodríguez, I | 1 |
| Sala Sánchez-Castillo, A | 1 |
| Delcán, JL | 1 |
| Pabón Osuna, P | 1 |
| Castaño Bazo, L | 1 |
| Ledesma García, C | 1 |
| Martín Luengo, C | 1 |
| de Castro del Pozo, S | 1 |
| Sowton, E | 2 |
| Kopelman, P | 1 |
| Morgan, PG | 1 |
| Sebille, A | 2 |
| Piris, P | 1 |
| Beaughard, M | 1 |
| Cosnier, D | 1 |
| Labrid, C | 1 |
| Raabe, DS | 1 |
| Bourrat, C | 2 |
| Viala, JJ | 1 |
| Guastala, JP | 1 |
| Mussini, JM | 1 |
| Hauw, JJ | 1 |
| Escourolle, R | 1 |
| Mabin, D | 1 |
| Penther, P | 1 |
| Blanc, JJ | 1 |
| Serot, JM | 1 |
| Floquet, A | 1 |
| Penin, F | 1 |
| Cuny, G | 1 |
| Grignon, G | 1 |
| Said, G | 1 |
| Pessayre, D | 1 |
| Bichara, M | 1 |
| Degott, C | 1 |
| Potet, F | 1 |
| Benhamou, JP | 1 |
| Feldmann, G | 1 |
| Bouche, P | 1 |
| Bousser, MG | 1 |
| Peytour, MA | 1 |
| Cathala, HP | 1 |
| Bady, B | 1 |
| Trillet, M | 1 |
| Girard, PF | 1 |
| Carrier, H | 1 |
| Stenbäck, U | 1 |
| Crittin, J | 2 |
| Mizgala, HF | 2 |
| Waters, DD | 2 |
| Théroux, P | 2 |
| Lespérance, J | 1 |
| Ghods, A | 1 |
| Baron, DK | 1 |
| Day, LJ | 1 |
| Pilcher, J | 6 |
| Bertrand, L | 1 |
| Baldet, P | 1 |
| Blanc, F | 1 |
| Puyeo, J | 1 |
| Breithaupt, H | 1 |
| Walter, P | 1 |
| Bozza, A | 2 |
| de Britto, AH | 1 |
| Malagrino, A | 1 |
| Nogueira, A | 2 |
| Besen, D | 1 |
| Santos, DV | 2 |
| Di Piero, EF | 1 |
| Ferreira, FM | 1 |
| Gomes, FJ | 2 |
| de Brito, FS | 2 |
| Dohmann, H | 1 |
| Arroyo, JB | 2 |
| Batlouni, M | 1 |
| Wagner, M | 1 |
| Studart, PC | 1 |
| Duprat, R | 1 |
| Federico, W | 1 |
| Pereira, MH | 1 |
| De'Thomatis, M | 1 |
| Falciola, N | 1 |
| Gallesio, R | 1 |
| Hitchcock, PJ | 1 |
| Rutovitz, IJ | 1 |
| Dando, RV | 1 |
| Eathorne, AJ | 1 |
| Weiss, G | 1 |
| Lewis, D | 1 |
| Wainwright, HC | 1 |
| Kew, MC | 1 |
| Zwi, S | 1 |
| Isaacson, C | 1 |
| Affaki, GS | 1 |
| Bonan, R | 1 |
| Mashford, ML | 3 |
| Roche, J | 1 |
| Fournet, J | 1 |
| Meullenet, J | 1 |
| Faure, H | 1 |
| Massot, C | 1 |
| Bregetzer, J | 1 |
| Stentiford, NH | 1 |
| Stephens, WP | 1 |
| Eddy, JD | 1 |
| Parsons, LM | 1 |
| Singh, SP | 1 |
| Cousteau, JP | 1 |
| Singlas, E | 2 |
| Assan, R | 2 |
| Bournerias, F | 1 |
| Margent, P | 1 |
| Goulon, M | 1 |
| Bonnet, P | 1 |
| Jourdan, J | 1 |
| Janbon, F | 1 |
| Michel, H | 1 |
| Bertrand, A | 1 |
| Linkesch, W | 1 |
| Glogar, D | 1 |
| Niederberger, M | 1 |
| Shalev, O | 1 |
| Bassan, M | 1 |
| Goujet, MA | 1 |
| Simon, P | 1 |
| Dalla Volta, S | 1 |
| Episcopo, U | 1 |
| Gemelli, A | 1 |
| Permutti, B | 1 |
| Greco, R | 1 |
| Boccalatte, A | 1 |
| Marsico, F | 1 |
| del Guercio, R | 1 |
| Masheter, HC | 2 |
| Caponnetto, S | 1 |
| Iannetti, M | 1 |
| Pastorini, C | 1 |
| Masperone, MA | 1 |
| Perugini, P | 1 |
| Forattini, C | 1 |
| Perin, S | 1 |
| Britto, AH | 1 |
| Piero, EF | 1 |
| Brito, FS | 1 |
| Laffront, G | 1 |
| Dohmann, HF | 1 |
| Masoni, A | 2 |
| Tomasi, AM | 2 |
| Oriani, GA | 1 |
| Brown, MJ | 1 |
| Tomlinson, IW | 1 |
| Rosenthal, FD | 1 |
| Dally, S | 1 |
| Lagier, G | 1 |
| Gaultier, M | 1 |
| Luyckx, A | 1 |
| Cauwenberge, HV | 1 |
| Cristallo, E | 1 |
| Palma, B | 1 |
| Fino, E | 1 |
| De Luca, I | 1 |
| Albanese, P | 1 |
| Mitolo, E | 1 |
| Lee, RJ | 1 |
| Gaudy, M | 1 |
| Gaudy, MC | 1 |
| Rullière, R | 1 |
| Bickert, P | 1 |
| Datey, KK | 5 |
| Bhagat, SJ | 1 |
| Iyer, RS | 1 |
| Surana, MC | 1 |
| Bhootra, RK | 3 |
| Rajalaxmi, BN | 1 |
| Mishra, SJ | 1 |
| Goyal, BK | 1 |
| Garten, J | 1 |
| Werhrschütz, E | 1 |
| Cunha, GP | 2 |
| Lopes, M | 2 |
| Maranhão, MF | 2 |
| Oliveira, PF | 1 |
| Rojas, RI | 1 |
| Corsini, G | 1 |
| Correale, E | 1 |
| Oriani, G | 1 |
| Persico, S | 1 |
| Tritto, C | 1 |
| Roger, P | 1 |
| Nogue, F | 1 |
| Ragnaud, JM | 1 |
| Manciet, G | 1 |
| Doumax, Y | 1 |
| Galassi, A | 1 |
| Mangiameli, S | 1 |
| Circo, A | 1 |
| Gatto, E | 1 |
| Corsini, B | 1 |
| Di Muzio, M | 1 |
| Satz, N | 1 |
| Täuber, M | 1 |
| Streuli, R | 1 |
| Spycher, MA | 1 |
| Maurer, R | 1 |
| Cole, PL | 1 |
| Beamer, AD | 1 |
| McGowan, N | 1 |
| Cantillon, CO | 1 |
| Benfell, K | 1 |
| Kelly, RA | 1 |
| Hartley, LH | 1 |
| Smith, TW | 1 |
| Antman, EM | 1 |
| Sia, ST | 1 |
| Macdonald, PS | 1 |
| Goble, AJ | 1 |
| Louis, WJ | 1 |
| Combes, P | 1 |
| Richard, M | 1 |
| Fargnoli, JM | 1 |
| Cooper, JD | 2 |
| Turnell, DC | 2 |
| Matenga, J | 1 |
| Paul, R | 1 |
| Lockhart, D | 1 |
| Armstrong, ML | 2 |
| Brand, D | 1 |
| Emmett, AJ | 1 |
| Hodge, JL | 1 |
| Kellaway, GS | 1 |
| Mestitz, P | 1 |
| Reefman, M | 1 |
| Charlier, R | 1 |
| Scebat, L | 1 |
| Alcocer, L | 2 |
| Aspe, J | 2 |
| Arce-Gomez, E | 2 |
| Warembourg, H | 1 |
| Carre, A | 1 |
| Ketelers, JY | 1 |
| Pepne, CJ | 1 |
| Schang, SJ | 3 |
| Bemiller, CR | 3 |
| Crevelier, A | 1 |
| Duplay, H | 1 |
| Fleury, G | 1 |
| Massabie, R | 1 |
| Dalvi, CP | 3 |
| Morgans, CM | 1 |
| Gitlin, N | 3 |
| Nellen, M | 1 |
| Libertti, A | 1 |
| Gregorini, L | 1 |
| Valentini, R | 1 |
| Concina, B | 1 |
| Marini, O | 1 |
| Antonioli, G | 1 |
| Chandrasekhar, KP | 2 |
| Boyce, MJ | 1 |
| Peirce, TH | 2 |
| Cawein, MJ | 2 |
| Lewis, RE | 1 |
| Hudak, WJ | 1 |
| Hoekenga, MT | 2 |
| Newberne, JW | 1 |
| Pepine, CJ | 3 |
| Morledge, J | 1 |
| Cherchi, A | 1 |
| Bina, M | 1 |
| Fonzo, R | 1 |
| Raffo, M | 1 |
| Bagri, AK | 1 |
| Kelkar, PN | 2 |
| Varma, SR | 1 |
| Amin, BM | 1 |
| Martins de Oliveira, J | 1 |
| Loyola, SF | 1 |
| Chaves, JL | 1 |
| Luccioni, R | 1 |
| Trigano, JA | 1 |
| Burns-Cox, CJ | 1 |
| Quinlan, CD | 1 |
| Garson, WP | 1 |
| Gülin, RC | 1 |
| Phear, DN | 1 |
| Bunde, CA | 1 |
| Kuzma, RJ | 1 |
| Griffin, CL | 1 |
| Kucuruza, I | 1 |
| Souza, AD | 1 |
| Rojas, R | 1 |
| Raynaud, P | 1 |
| Binet, P | 1 |
| Henin, JM | 1 |
| Raynaud, R | 1 |
| Barraine, R | 1 |
| Demange, J | 1 |
| Marin, J | 1 |
| Linquette, M | 1 |
| Mesmacque, R | 1 |
| Benoit, G | 1 |
| Hiltgen, M | 1 |
| Steff, PH | 1 |
| Gerbaux, A | 1 |
| Saint-Pierre, A | 1 |
| Perrin, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Metabolic Support With Perhexiline to Protect Myocardium Undergoing Coronary Artery Surgery[NCT00845364] | Phase 2/Phase 3 | 290 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| Myocardial Protection With Perhexiline in Left Ventricular Hypertrophy[NCT00989508] | Phase 2/Phase 3 | 220 participants (Anticipated) | Interventional | 2009-10-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 reviews available for perhexiline and Angina Pectoris
| Article | Year |
|---|---|
Drugs that Affect Cardiac Metabolism: Focus on Perhexiline.
Topics: Angina Pectoris; Animals; Cardiovascular Agents; Fatty Acids; Glucose; Humans; Mitochondria; Myocard | 2016 |
Chronic stable angina pectoris.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetanilides; Angina Pectoris; Antihypertensive Agent | 2008 |
Systematic review of the efficacy and safety of perhexiline in the treatment of ischemic heart disease.
Topics: Angina Pectoris; Cardiovascular Agents; Dose-Response Relationship, Drug; Drug Interactions; Drug Th | 2001 |
Metabolic manipulation in ischaemic heart disease, a novel approach to treatment.
Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Cardiovascular Agents; Drug Therapy, Com | 2004 |
Metabolic therapeutics in angina pectoris: history revisited with perhexiline.
Topics: Acetanilides; Angina Pectoris; Calcium Channel Blockers; Cardiovascular Agents; Carnitine O-Palmitoy | 2006 |
Perhexiline.
Topics: Angina Pectoris; Animals; Aortic Valve Stenosis; Calcium Channel Blockers; Carnitine O-Palmitoyltran | 2007 |
Perhexiline.
Topics: Angina Pectoris; Animals; Aortic Valve Stenosis; Calcium Channel Blockers; Carnitine O-Palmitoyltran | 2007 |
Perhexiline.
Topics: Angina Pectoris; Animals; Aortic Valve Stenosis; Calcium Channel Blockers; Carnitine O-Palmitoyltran | 2007 |
Perhexiline.
Topics: Angina Pectoris; Animals; Aortic Valve Stenosis; Calcium Channel Blockers; Carnitine O-Palmitoyltran | 2007 |
[Strategy of the medical treatment of angina pectoris].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Amiodarone; Angina Pectoris; Calcium Channel Blocke | 1983 |
[Treatment of angina pectoris with calcium antagonists].
Topics: Angina Pectoris; Calcium Channel Blockers; Coronary Disease; Diltiazem; Drug Therapy, Combination; E | 1982 |
Is perhexiline essential for the optimal management of angina pectoris?
Topics: Angina Pectoris; Australia; Drug Utilization; Humans; New Zealand; Perhexiline | 1995 |
[Toxic neurologic manifestations during angina pectoris treatment (perhexiline maleate and amiotadone hydrochloride)].
Topics: Amiodarone; Angina Pectoris; Benzofurans; Cerebrospinal Fluid Proteins; Electromyography; Humans; In | 1978 |
[Cirrhogenic hepatitis due to perhexiline maleate: general review based upon one new case with ultrastructural study (author's transl)].
Topics: Aged; Angina Pectoris; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Hepa | 1978 |
[Treatment of angina pectoris (III)].
Topics: Angina Pectoris; Angina Pectoris, Variant; Coronary Artery Bypass; Humans; Nifedipine; Perhexiline; | 1979 |
[Medical therapy of chronic coronary insufficiency].
Topics: Amiodarone; Angina Pectoris; Chronic Disease; Coronary Disease; Digitalis Glycosides; Humans; Lidofl | 1978 |
[Physiopathology of angina and long term antianginal medication. Current concepts].
Topics: Adrenergic beta-Antagonists; Amiodarone; Angina Pectoris; Blood Flow Velocity; Cardiac Output; Coron | 1974 |
58 trials available for perhexiline and Angina Pectoris
| Article | Year |
|---|---|
Beneficial clinical effects of perhexiline in patients with stable angina pectoris and acute coronary syndromes are associated with potentiation of platelet responsiveness to nitric oxide.
Topics: Aged; Angina Pectoris; Blood Platelets; Cardiovascular Agents; Coronary Disease; Cyclic GMP; Female; | 2002 |
Clinical inhibition of CYP2D6-catalysed metabolism by the antianginal agent perhexiline.
Topics: Aged; Angina Pectoris; Cardiovascular Agents; Cytochrome P-450 CYP2D6 Inhibitors; Dextromethorphan; | 2004 |
Effects of perhexiline and nitroglycerin on vascular, neutrophil and platelet function in patients with stable angina pectoris.
Topics: Angina Pectoris; Arteries; Cardiovascular Physiological Phenomena; Drug Interactions; Female; Humans | 2007 |
Letter: A multicentre trial of perhexiline maleats, beta-blocker and placebo in angina pectoris.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Clinical Trials as Topic; Humans; Perhexiline; Piperid | 1975 |
[Clinical examination of perhexilinemaleate efficiency in the therapy of angina pectoris].
Topics: Adult; Angina Pectoris; Chemical Phenomena; Chemistry; Clinical Trials as Topic; Female; Humans; Mal | 1977 |
The treatment of angina pectoris. A trial of perhexiline maleate in patients with angiographically normal coronary arteries.
Topics: Angina Pectoris; Clinical Trials as Topic; Double-Blind Method; Humans; Perhexiline; Piperidines | 1978 |
Comparative trial of perhexiline maleate and oxprenolol in patients with angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Oxprenolo | 1978 |
[Perhexiline maleate in a multicentric study in Brazil - a new model of a clinical protocol and mechanism of action of the drug].
Topics: Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Humans; Perhexiline; Physical Exertion; | 1979 |
[Verapamil in the treatment of angina pectoris. Double-blind study with clinical and ergometric evaluation].
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Electro | 1979 |
A multicentre trial of perhexiline maleate in the treatment of angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Male; Middl | 1977 |
[Clinical efficacy of perhexiline maleate in stable angina pectoris (author's transl)].
Topics: Adult; Aged; Angina Pectoris; Double-Blind Method; Exercise Test; Heart Rate; Humans; Middle Aged; M | 1978 |
[Treatment of angina pectoris with perhexiline maleate. Clinical evaluation in controlled double-blind study with placebo and prenylamine].
Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Female; Humans; Male; Maleates; Middle Aged; | 1976 |
[Treatment of angina pectoris with perhexilene maleate].
Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Male; Middl | 1975 |
[Experimental study on a new antianginal drug: perhexiline maleate].
Topics: Aged; Angina Pectoris; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Male; Middle Aged; | 1975 |
Letter: Perhexiline maleate in angina pectoris.
Topics: Angina Pectoris; Clinical Trials as Topic; Drug Evaluation; Humans; Perhexiline; Piperidines | 1976 |
[Effects of perhexiline maleate in angina pectoris: preliminary clinical and experimental results of a comparative study].
Topics: Angina Pectoris; Clinical Trials as Topic; Drug Evaluation; Humans; Perhexiline; Piperidines; Placeb | 1975 |
[Perhexiline maleate in the treatment of angina pectoris].
Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Male; Middl | 1976 |
[Multicentric study with perhexiline maleate in angina pectoris. Preliminary report].
Topics: Angina Pectoris; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Male; Maleates; Perhexil | 1976 |
Clinical evaluation of perhexiline maleate in the treatment of patients with chronic coronary insufficiency.
Topics: Administration, Oral; Aged; Alanine Transaminase; Angina Pectoris; Animals; Arrhythmias, Cardiac; As | 1975 |
A double-blind trial of perhexiline maleate in the prophylaxis of angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Depression, Chemical; Female; Heart Rate; Hu | 1976 |
Report of a multicentre monitored release study of perhexiline maleate in the prevention of angina pectoris.
Topics: Angina Pectoris; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Nitroglycerin; Perhexi | 1976 |
[Pexide, a new coronary drug].
Topics: Angina Pectoris; Animals; Arrhythmias, Cardiac; Clinical Trials as Topic; Dogs; Hemodynamics; Humans | 1975 |
[Perhexiline maleate in the treatment of angina pectoris - double blind study].
Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Male; Middl | 1975 |
[Clinical trial by perexiline maleate in treatment of angina pectoris (author's transl)].
Topics: Angina Pectoris; Blood Pressure; Body Weight; Drug Evaluation; Electrocardiography; Headache; Humans | 1975 |
Efficacy and safety of perhexiline maleate in refractory angina. A double-blind placebo-controlled clinical trial of a novel antianginal agent.
Topics: Aged; Angina Pectoris; Clinical Trials as Topic; Double-Blind Method; Exercise Test; Female; Half-Li | 1990 |
A multicentre trial of perhexiline maleate, beta-blocker and placebo in angina pectoris.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Alanine Transaminase; Angina Pectoris; Aspartate Aminotran | 1974 |
[Current acquisitions in treatment of angina pertoris].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Antidepressive Agents; Humans; Maleates; Perhexiline; | 1974 |
Effects of perhexiline maleate in patients with angina pectoris unrelieved by other antianginal agent.
Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Electrocardiography; Evaluation Studies as T | 1973 |
Treadmill exercise-tolerance test behavior in anginal patients treated with perhexiline maleate.
Topics: Adult; Aerobiosis; Angina Pectoris; Clinical Trials as Topic; Exercise Test; Female; Heart Rate; Hum | 1974 |
Effects of perhexiline on symptomatic and hemodynamic responses to exercise in patients with angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Arteriosclerosis; Blood Pressure; Catheterization; Clinical Trials as | 1974 |
A new approach to the evaluation of anti-anginal drugs (with special reference to Perhexiline maleate).
Topics: Angina Pectoris; Clinical Trials as Topic; Female; Humans; Male; Methods; Perhexiline; Piperidines; | 1973 |
The action of perhexiline maleate in patients with angina.
Topics: Aged; Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Electrocardiography; Exercise Test; | 1973 |
Proceedings: Perhexiline maleate in the treatment of angina pectoris: a double-blind trial.
Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Perhexili | 1973 |
Proceedings: Double-blind clinical trial with perhexiline in out-patients with angia pectoris.
Topics: Angina Pectoris; Clinical Trials as Topic; Humans; Outpatient Clinics, Hospital; Perhexiline; Piperi | 1973 |
Proceedings: A comparative study of perhexiline, beta-adrenergic blocking agents and placebos in the management of angina pectoris.
Topics: Angina Pectoris; Clinical Trials as Topic; Humans; Perhexiline; Piperidines; Placebos; Practolol; Pr | 1973 |
Proceedings: Long-term assessment of perhexiline maleate in angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Female; Humans; Liver; Liver Function Tests; | 1973 |
Proceedings: A long-term assessment of perhexiline maleate in the management of patients with angina pectoris.
Topics: Angina Pectoris; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Perhexiline; Piperidin | 1973 |
Proceedings: Clinical evaluation of perhexiline maleate in patients with angina pectoris associated with a positive coronary artery disease index.
Topics: Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Female; Humans; Male; Perhexiline; Pipe | 1973 |
Proceedings: Assessment of safety data from patients on short and long-term perhexiline therapy.
Topics: Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Enzyme Induction; Enzymes; Humans; Perh | 1973 |
Proceedings: Alteration of left ventricular responses to ischemia with oral perhexiline.
Topics: Adult; Angina Pectoris; Clinical Trials as Topic; Heart; Heart Ventricles; Humans; Male; Middle Aged | 1973 |
Proceedings: Effects of perhexiline maleate in angina pectoris: a double-blind clinical evaluation with ECG-treadmill exercise testing.
Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Electrocardiography; Exercise Test; Female; | 1973 |
Proceedings: Influence of perhexiline on the effort tolerance test in angina pectoris. Comparison with placebo and prenylamine.
Topics: Aged; Angina Pectoris; Clinical Trials as Topic; Exercise Test; Female; Humans; Male; Middle Aged; P | 1973 |
Proceedings: Perhexiline maleate: a new anti-anginal drug.
Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Perhexili | 1973 |
Proceedings: Perhexiline maleate: eighteen months of continuous administration in patients with angina pectoris.
Topics: Adult; Aged; Alanine Transaminase; Angina Pectoris; Aspartate Aminotransferases; Clinical Trials as | 1973 |
Proceedings: Clinical and statistical evaluation of the effect of perhexiline maleate in patients with chronic angina.
Topics: Angina Pectoris; Chronic Disease; Clinical Trials as Topic; Humans; Middle Aged; Perhexiline; Piperi | 1973 |
Proceedings: Clinical evaluation of perhexiline maleate in patients with angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Perhexili | 1973 |
Proceedings: Clinical experience with perhexiline maleate in forty-six patients with angina.
Topics: Adult; Aged; Angina Pectoris; Anticoagulants; Clinical Trials as Topic; Female; Humans; Male; Middle | 1973 |
Proceedings: Clinical results with a new antianginal drug (perhexiline maleate).
Topics: Angina Pectoris; Body Weight; Clinical Trials as Topic; Humans; Perhexiline; Piperidines; Vasodilato | 1973 |
[Clinical evaluation of perhexiline maleate in angina patients].
Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Evaluation Studies as Topic; Female; Humans; | 1973 |
[Perhexiline maleate in angina pectoris. Study of tolerance to treadmill exercise].
Topics: Aged; Angina Pectoris; Clinical Trials as Topic; Electrocardiography; Evaluation Studies as Topic; E | 1973 |
The action of perhexiline maleate in patients with angina and its effect on liver function.
Topics: Adult; Aged; Angina Pectoris; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Dose | 1973 |
Assessment of perhexiline maleate in ischaemic heart disease.
Topics: Aged; Angina Pectoris; Clinical Trials as Topic; Evaluation Studies as Topic; Female; Humans; Male; | 1973 |
[Perhexiline maleate in angina pectoris. Cross double blind evaluation controlled with placebo].
Topics: Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Evaluation Studies as Topic; Humans; Male | 1973 |
[A new anti-angina drug: Perhexiline maleate. Apropos of 50 cases].
Topics: Angina Pectoris; Clinical Trials as Topic; Drug Evaluation; Drug Tolerance; Electrocardiography; Fem | 1973 |
Perhexiline maleate in the management of patients with angina pectoris. A long-term assessment.
Topics: Aged; Angina Pectoris; Arrhythmias, Cardiac; Aspartate Aminotransferases; Clinical Trials as Topic; | 1974 |
Perhexiline maleate, a new anti-anginal drug, evaluated by "modified double blind double cross over study".
Topics: Administration, Oral; Adult; Aged; Alanine Transaminase; Angina Pectoris; Blood Pressure; Body Weigh | 1974 |
[Study of perhexiline maleate in the treatment of severe chronic coronary insufficiency].
Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Female; Humans; Male; Male | 1974 |
Warner oration. Advances in drug therapy of angina pectoris, with special reference to perhexiline maleate.
Topics: Angina Pectoris; Clinical Trials as Topic; Female; Humans; Male; Perhexiline; Placebos; Practolol; V | 1974 |
92 other studies available for perhexiline and Angina Pectoris
| Article | Year |
|---|---|
Multi-centre experience on the use of perhexiline in chronic heart failure and refractory angina: old drug, new hope.
Topics: Aged; Analysis of Variance; Angina Pectoris; Cardiovascular Agents; Confidence Intervals; Drug Monit | 2009 |
Effects of aging, renal dysfunction, left ventricular systolic impairment, and weight on steady state pharmacokinetics of perhexiline.
Topics: Aged; Aged, 80 and over; Aging; Angina Pectoris; Body Weight; Cardiovascular Agents; Creatinine; Hum | 2011 |
Pharmacokinetics of the antianginal agent perhexiline: relationship between metabolic ratio and steady-state dose.
Topics: Angina Pectoris; Biological Availability; Cardiovascular Agents; Chromatography, High Pressure Liqui | 2002 |
Concentration-time profile for perhexiline and hydroxyperhexiline in patients at steady state.
Topics: Aged; Aged, 80 and over; Angina Pectoris; Calcium Channel Blockers; Female; Humans; Male; Perhexilin | 2004 |
Effect of the anti-anginal agent, perhexiline, on neutrophil, valvular and vascular superoxide formation.
Topics: Angina Pectoris; Animals; Animals, Newborn; Aorta, Thoracic; Aortic Valve; Cardiovascular Agents; Ce | 2006 |
Drugs and the heart. III. Calcium antagonists.
Topics: Angina Pectoris; Aniline Compounds; Arrhythmias, Cardiac; Calcium; Cardiomegaly; Diuretics; Heart Di | 1980 |
Adverse effects of perhexiline.
Topics: Adult; Aged; Angina Pectoris; Female; Humans; Liver Cirrhosis; Male; Perhexiline; Peripheral Nervous | 1982 |
Perhexiline hepatitis and HLA-B8.
Topics: Angina Pectoris; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Genes; Hep | 1982 |
Antianginal efficacy of perhexiline maleate in patients refractory to beta-adrenoreceptor blockade.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Double-Blind Method; Drug Resistance; Hum | 1983 |
Perhexiline maleate as a cause of reversible parkinsonism and peripheral neuropathy.
Topics: Aged; Angina Pectoris; Female; Humans; Parkinson Disease, Secondary; Perhexiline; Peripheral Nervous | 1981 |
Impaired oxidation of debrisoquine in patients with perhexiline neuropathy.
Topics: Adult; Aged; Alcohol Drinking; Angina Pectoris; Debrisoquin; Female; Humans; Isoquinolines; Liver Fu | 1982 |
Prediction of subclinical perhexiline neuropathy in a patient with inborn error of debrisoquine hydroxylation.
Topics: Angina Pectoris; Debrisoquin; Electromyography; Humans; Hydroxylation; Isoquinolines; Male; Middle A | 1983 |
Perhexilene neuropathy: a report of two cases.
Topics: Angina Pectoris; Female; Humans; Leg; Male; Middle Aged; Neural Conduction; Pain; Paresthesia; Perhe | 1983 |
Calcium antagonists, nitrates, and new antianginal drugs.
Topics: Angina Pectoris; Calcium Channel Blockers; Humans; Hypertension; Isosorbide Dinitrate; Lidoflazine; | 1983 |
[The classic anti-anginal agents and molsidomine].
Topics: Amiodarone; Angina Pectoris; Angina Pectoris, Variant; Humans; Kinetics; Molsidomine; Oxadiazoles; P | 1983 |
Impaired oxidation of debrisoquine in patients with perhexiline liver injury.
Topics: Adolescent; Adult; Aged; Angina Pectoris; Chemical and Drug Induced Liver Injury; Chronic Disease; D | 1984 |
Calcium channel blockers.
Topics: Angina Pectoris; Angina Pectoris, Variant; Arrhythmias, Cardiac; Calcium Channel Blockers; Diltiazem | 1983 |
Perhexiline: good for refractory angina but take care!
Topics: Angina Pectoris; Humans; Perhexiline; Piperidines; Premedication | 1983 |
Perhexiline maleate induced cirrhosis.
Topics: Aged; Angina Pectoris; Female; Humans; Liver; Liver Cirrhosis; Perhexiline; Piperidines | 1983 |
Unstable angina and perhexilene maleate.
Topics: Angina Pectoris; Humans; Perhexiline; Piperidines | 1981 |
Papilledema without peripheral neuropathy in a patient taking perhexiline maleate.
Topics: Adult; Angina Pectoris; Fluorescein Angiography; Humans; Male; Papilledema; Perhexiline; Piperidines | 1982 |
Effects of calcium antagonists, especially nifedipine, on variant angina, resting angina, and unstable angina.
Topics: Aged; Angina Pectoris; Angina Pectoris, Variant; Calcium Channel Blockers; Coronary Vasospasm; Dilti | 1982 |
Calcium antagonists.
Topics: Angina Pectoris; Calcium Channel Blockers; Cell Membrane; Diltiazem; Heart; Humans; Hypertension; Mu | 1980 |
Clinical use of calcium entry blockers.
Topics: Angina Pectoris; Calcium Channel Blockers; Cinnarizine; Coronary Circulation; Coronary Vasospasm; Di | 1981 |
Liver disease induced by perhexiline maleate.
Topics: Angina Pectoris; Chemical and Drug Induced Liver Injury; Humans; Liver; Liver Cirrhosis, Alcoholic; | 1981 |
[Calcium inhibitors. Current indications in cardiology].
Topics: Angina Pectoris; Arrhythmias, Cardiac; Calcium; Cardiovascular Diseases; Diltiazem; Humans; Nifedipi | 1980 |
Perhexiline maleate-associated hepatic injury prevalence and characteristics.
Topics: Adult; Aged; Angina Pectoris; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Female; France | 1980 |
Papilloedema and hepatic dysfunction apparently induced by perhexiline maleate (Pexid).
Topics: Angina Pectoris; Chemical and Drug Induced Liver Injury; Humans; Male; Middle Aged; Papilledema; Per | 1980 |
Toxic polyneuritis and toxic hepatitis related to long-term perhexiline maleate therapy.
Topics: Angina Pectoris; Chemical and Drug Induced Liver Injury; Humans; Male; Middle Aged; Perhexiline; Pip | 1980 |
Hepatotoxicity following treatment with perhexiline maleate.
Topics: Aged; Angina Pectoris; Chemical and Drug Induced Liver Injury; Female; Humans; Male; Middle Aged; Pe | 1980 |
Perhexiline--stable plasma concentrations with formulation change.
Topics: Aged; Angina Pectoris; Biological Availability; Cardiovascular Agents; Drug Compounding; Female; Hum | 1996 |
Assessment of interlaboratory performance in the provision of perhexiline therapeutic drug monitoring services in Australia.
Topics: Angina Pectoris; Australia; Cardiovascular Agents; Chromatography, Gas; Chromatography, High Pressur | 1999 |
[General practicioner in face of angina pectoris (author's transl)].
Topics: Adrenergic beta-Antagonists; Amiodarone; Angina Pectoris; Diet, Reducing; Exercise Therapy; Family P | 1977 |
Angina.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Humans; Isosorbide Dinitrate; Nifedipine; Nitroglyceri | 1978 |
Perhexiline maleate in the treatment of angina pectoris. Five years of personal clinical experience.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Australia; Drug Therapy, Combination; Fem | 1978 |
[Physiopathological and therapeutical considerations of Prinzmetal's angina. Apropos of 7 cases].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Angina Pectoris, Variant; Coronary Vessel | 1979 |
Angina pectoris: current approach to treatment.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Coronary Artery Bypass; Humans; Nitroglycerin; Pain; P | 1979 |
The treatment of angina pectoris.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Coronary Angiography; Humans; Isosorbide Dinitrate; Mi | 1979 |
[Perhexilinemaleate--a new monodrug in the field of coronary therapeutic agents].
Topics: Angina Pectoris; Cardiac Complexes, Premature; Congresses as Topic; Coronary Disease; Germany, West; | 1975 |
Liver damage after perhexiline maleate.
Topics: Angina Pectoris; Chemical and Drug Induced Liver Injury; Humans; Male; Middle Aged; Perhexiline; Pip | 1977 |
[Electrophysiological study of latent neuropathies induced by perhexiline].
Topics: Adult; Aged; Angina Pectoris; Electric Stimulation; Evoked Potentials; H-Reflex; Humans; Middle Aged | 1978 |
Activity of bepridil and other anti-anginals on cardiovascular modifications engendered by conditioned anxiety in the dog.
Topics: Amines; Amiodarone; Angina Pectoris; Animals; Anxiety; Behavior, Animal; Benzylamines; Conditioning, | 1978 |
Treatment of variant angina pectoris with perhexilene maleate.
Topics: Angina Pectoris; Angina Pectoris, Variant; Coronary Angiography; Drug Evaluation; Electrocardiograph | 1979 |
[Letter: Peripheral neuropathy after prolonged adsorption of perhexiline maleate. 2 cases].
Topics: Aged; Angina Pectoris; Humans; Male; Maleates; Paresthesia; Parkinson Disease, Secondary; Perhexilin | 1975 |
[Electron microscopic study of nerve, muscle and skin lesions induced by perhexiline maleate (author's transl)].
Topics: Aged; Angina Pectoris; Female; Humans; Male; Microscopy, Electron; Middle Aged; Muscles; Muscular At | 1977 |
[Electromyogram and nervous conduction speeds during prolonged treatment by perhexiline maleate (author's transl)].
Topics: Adult; Aged; Angina Pectoris; Electromyography; Female; Humans; Long-Term Care; Male; Middle Aged; N | 1977 |
[Ultrastructural study of the liver after treatment with perhexiline maleate].
Topics: Aged; Angina Pectoris; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Perhexiline; P | 1977 |
Perhexiline neuropathy: a clinicopathological study.
Topics: Aged; Angina Pectoris; Demyelinating Diseases; Female; Humans; Male; Middle Aged; Nerve Fibers; Perh | 1978 |
Perhexiline maleate-induced cirrhosis.
Topics: Aged; Angina Pectoris; Chemical and Drug Induced Liver Injury; Cytoplasmic Granules; Female; Hepatic | 1979 |
Perhexiline maleate and peripheral neuropathy.
Topics: Adult; Aged; Angina Pectoris; Electromyography; Female; Follow-Up Studies; Humans; Male; Middle Aged | 1979 |
Recurrence of Prinzmetal angina seven years following aortocoronary bypass surgery: a clinical and angiographic follow-up.
Topics: Adult; Angina Pectoris; Angina Pectoris, Variant; Coronary Artery Bypass; Electrocardiography; Follo | 1979 |
The management of the patient with angina.
Topics: Angina Pectoris; Anticoagulants; Clofibrate; Coronary Artery Bypass; Diazepam; Digoxin; Humans; Isos | 1977 |
Liver damage associated with perhexiline maleate.
Topics: Aged; Angina Pectoris; Chemical and Drug Induced Liver Injury; Humans; Liver; Male; Middle Aged; Per | 1979 |
Provocative testing with ergonovine to evaluate the efficacy of treatment with calcium antagonists in variant angina.
Topics: Adult; Aged; Angina Pectoris; Angina Pectoris, Variant; Electrocardiography; Ergonovine; Evaluation | 1979 |
Long-term safety of perhexiline maleate.
Topics: Angina Pectoris; Body Weight; Humans; Liver Diseases; Neuromuscular Diseases; Perhexiline; Piperidin | 1979 |
[Acute hepatic failure due to perhexiline maleate].
Topics: Aged; Angina Pectoris; Chemical and Drug Induced Liver Injury; Humans; Liver Cirrhosis; Male; Perhex | 1979 |
Perhexiline maleate in the treatment of severe angina pectoris.
Topics: Alprenolol; Angina Pectoris; Drug Therapy, Combination; Electrocardiography; Female; Humans; Male; M | 1979 |
[Various new anti-angina medications].
Topics: Amiodarone; Angina Pectoris; Benzofurans; Humans; Isosorbide Dinitrate; Perhexiline; Piperidines | 1977 |
Perhexiline maleate toxicity: a case of severe jaundice.
Topics: Adult; Angina Pectoris; Humans; Jaundice; Male; Perhexiline; Piperidines | 1977 |
Raised intracranial pressure due to perhexiline maleate.
Topics: Adult; Angina Pectoris; Female; Humans; Intracranial Pressure; Male; Middle Aged; Papilledema; Perhe | 1978 |
Drug treatment of chronic stable angina pectoris.
Topics: Angina Pectoris; Chronic Disease; Humans; Nifedipine; Nitrites; Perhexiline; Verapamil | 1978 |
Prevalence of latent perhexiline neuropathy.
Topics: Angina Pectoris; H-Reflex; Humans; Nervous System Diseases; Perhexiline; Piperidines | 1978 |
[Can one give perhexiline to diabetics?].
Topics: Angina Pectoris; Body Weight; Chemical and Drug Induced Liver Injury; Diabetes Complications; Diabet | 1978 |
[Hepatitis and acute renal failure following halothane anaesthesia in a patient treated with perhexiline maleate (author's transl)].
Topics: Acute Kidney Injury; Aged; Angina Pectoris; Chemical and Drug Induced Liver Injury; Drug Synergism; | 1978 |
[Liver cirrhosis after 2 years of perhexiline maleate treatment].
Topics: Angina Pectoris; Diagnosis, Differential; Hepatitis, Alcoholic; Humans; Liver Cirrhosis; Male; Middl | 1978 |
[Perhexilene maleate--a new drug for the treatment of angina pectoris].
Topics: Angina Pectoris; Humans; Perhexiline; Piperidines | 1978 |
Pharmacokinetics of perhexiline maleate in anginal patients with and without peripheral neuropathy.
Topics: Aged; Angina Pectoris; Female; Humans; Kinetics; Male; Middle Aged; Nervous System Diseases; Perhexi | 1978 |
Proximal myopathy after perhexiline maleate treatment.
Topics: Aged; Angina Pectoris; Female; Humans; Muscular Diseases; Perhexiline; Piperidines | 1977 |
[Hypoglycemia in 2 patients treated with perhexiline maleate].
Topics: Aged; Angina Pectoris; Blood Glucose; Female; Glucagon; Humans; Hypoglycemia; Insulin; Male; Perhexi | 1977 |
[News on drug therapy 1976].
Topics: Angina Pectoris; Anti-Bacterial Agents; Bacterial Infections; Diuretics; Drug Therapy; Humans; Perhe | 1977 |
[Antiarrhythmic and antianginose activity of perhexiline maleate].
Topics: Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Drug Evaluation; Female; Humans; Male; Middle Ag | 1977 |
Effect of chronic administration of perhexiline on pacing-induce S-T segment depression in the atherosclerotic rabbit.
Topics: Angina Pectoris; Animals; Arteriosclerosis; Disease Models, Animal; Electrocardiography; Heart Rate; | 1976 |
[Long-term study of exercise tolerance in angina patients treated with perhexiline].
Topics: Adult; Aged; Angina Pectoris; Exercise Test; Humans; Male; Middle Aged; Perhexiline; Piperidines | 1976 |
[2 new anti-angina drugs: amiodarone and perhexiline maleate. Advantages and adverse effects].
Topics: Amiodarone; Angina Pectoris; Benzofurans; Humans; Perhexiline; Piperidines | 1976 |
Perhexiline in angina pectoris.
Topics: Angina Pectoris; Animals; Humans; Perhexiline; Piperidines | 1976 |
Perhexiline maleate in angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Female; Humans; Male; Middle Aged; Perhexiline; Piperidines | 1976 |
[Letter: Hypoglycemia after perhexiline maleate].
Topics: Aged; Angina Pectoris; Female; Humans; Hypoglycemia; Maleates; Perhexiline; Piperidines | 1975 |
[Use of perhexiline maleate in angina pectoris].
Topics: Aged; Angina Pectoris; Drug Evaluation; Humans; Male; Middle Aged; Perhexiline; Piperidines | 1975 |
[Clinical, polygraphic and echocardiographic evaluation of the action of perhexeline maleate in angina patients].
Topics: Angina Pectoris; Drug Evaluation; Echocardiography; Electrocardiography; Heart; Humans; Perhexiline; | 1975 |
Perhexiline maleate-induced hepatitis.
Topics: Angina Pectoris; Biopsy; Chemical and Drug Induced Liver Injury; Debrisoquin; Humans; Liver; Male; M | 1991 |
Perhexiline maleate treatment for severe angina pectoris--correlations with pharmacokinetics.
Topics: Adult; Aged; Angina Pectoris; Angina, Unstable; Drug Administration Schedule; Female; Humans; Kineti | 1986 |
[Other drugs used in angina pectoris].
Topics: Amiodarone; Angina Pectoris; Humans; Molsidomine; Perhexiline; Prenylamine; Sydnones; Vasodilator Ag | 1985 |
Investigations of long-term treatment with perhexiline maleate using therapeutic monitoring and electromyography.
Topics: Adult; Aged; Angina Pectoris; Electromyography; Female; Humans; Male; Middle Aged; Monitoring, Physi | 1985 |
Therapeutic monitoring of the anti-anginal drug perhexiline maleate.
Topics: Angina Pectoris; Humans; Male; Perhexiline | 1985 |
[Clinical trial of a new anti-angina agent: perhexiline maleate].
Topics: Adult; Aged; Angina Pectoris; Electrocardiography; Female; Humans; Male; Middle Aged; Nitroglycerin; | 1973 |
[Letter: Perhexiline maleate and lipid metabolism disorders].
Topics: Angina Pectoris; Cholesterol; Humans; Hyperlipidemias; Lipid Metabolism; Perhexiline; Triglycerides; | 1974 |
[Perhexiline maleate in coronary insufficiency. Clinical research].
Topics: Administration, Oral; Adult; Aged; Angina Pectoris; Coronary Disease; Electrocardiography; Female; H | 1974 |
Effects of perhexiline on left ventricular responses to exercise and atrial pacing.
Topics: Angina Pectoris; Evaluation Studies as Topic; Heart Ventricles; Hemodynamics; Humans; Perhexiline; P | 1973 |
[Clinical study of a new anti-angina agent: perhexiline maleate].
Topics: Aged; Angina Pectoris; Drug Evaluation; Electrocardiography; Female; Humans; Male; Middle Aged; Perh | 1973 |
[Letter: Nonspecific abnormalities of ventricular repolarization induced by perhexiline (apropos of 3 cases)].
Topics: Angina Pectoris; Electrocardiography; Perhexiline; Piperidines; Vasodilator Agents | 1974 |
[Letter: Electrocardiographic changes due to perhexiline maleate].
Topics: Aged; Angina Pectoris; Electrocardiography; Humans; Male; Perhexiline; Piperidines; Vasodilator Agen | 1974 |
Effects of perhexiline on coronary hemodynamic and myocardial metabolic responses to tachycardia.
Topics: Adult; Angina Pectoris; Blood Flow Velocity; Blood Pressure; Cardiac Output; Coronary Circulation; C | 1974 |