perhexiline has been researched along with Acute Liver Injury, Drug-Induced in 49 studies
Perhexiline: 2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The entire spectrum of alcoholic liver disease, including alcoholic hepatitis, may be perfectly mimicked by severe obesity, diabetes, and perhexiline maleate toxicity." | 3.67 | Problems in the necropsy diagnosis of alcoholic liver disease. ( Pounder, DJ, 1984) |
| "Case report of polyneuritis and liver dysfunction induced by perhexiline maleate in a 64 years old male patient." | 3.66 | [Diffuse polymorphous inclusions in a patient treated with perhexiline maleate (author's transl)]. ( de Saint-Maur, PP; Hauw, JJ; Lageron, A; Lecomte, D; Pollet, S; Poupon, R; Singer, B, 1978) |
| "The authors report the cases of 2 patients who died from cirrhosis after receiving perhexiline maleate, a drug widely used in Europe for the treatment of angina pectoris." | 3.66 | Perhexiline maleate-induced cirrhosis. ( Benhamou, JP; Bichara, M; Degott, C; Feldmann, G; Pessayre, D; Potet, F, 1979) |
| "Drug-induced steatohepatitis is a rare form of liver injury known to be caused by only a handful of compounds." | 2.52 | Mechanistic review of drug-induced steatohepatitis. ( Guo, GL; Schumacher, JD, 2015) |
| "Perhexiline is a prophylactic antianginal agent developed in the 1970s." | 1.72 | Study of the roles of cytochrome P450 (CYPs) in the metabolism and cytotoxicity of perhexiline. ( Chen, S; Guo, L; Li, F; Qin, X; Ren, Z, 2022) |
| "Perhexiline is a coronary vasodilator for angina treatment that was first developed in the 1960s." | 1.62 | A mechanism of perhexiline's cytotoxicity in hepatic cells involves endoplasmic reticulum stress and p38 signaling pathway. ( Chen, S; Guo, L; Pak, S; Ren, Z, 2021) |
| "Perhexiline treatment also caused a significant increase in caspase 3/7 activity at 2 h and 4 h." | 1.56 | Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline. ( Chen, S; Guo, L; Guo, X; Li, D; Ning, B; Ren, Z; Seo, JE, 2020) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "We report on a case of perhexiline maleate-induced hepatitis secondary to a long-term administration of recommended daily dosages of 300 mg." | 1.28 | Perhexiline maleate-induced hepatitis. ( Maurer, R; Satz, N; Spycher, MA; Streuli, R; Täuber, M, 1991) |
| "Perhexiline maleate is an antianginal agent which depends on hepatic oxidation for its elimination." | 1.27 | Impaired oxidation of debrisoquine in patients with perhexiline liver injury. ( Morgan, MY; Oates, NS; Reshef, R; Shah, RR; Sherlock, S; Smith, RL, 1984) |
| "Treatment of griseofulvin alone gave rise to hepatitis with the presence of Mallory bodies (MB) whereas the same length of treatment with Perhexilin Maleate was associated with steatonecrosis with an absence of MB." | 1.26 | [Comparative hepatic toxicity of perhexiline maleate and griseofulvin in mice]. ( Boucard, M; François, C; Michel, H; Sablier, G; Sentein, P; Vic, P, 1981) |
| "Perhexiline maleate is an anti-anginal drug believed to cause liver damage." | 1.26 | The effects of perhexiline maleate (Pexid) and alcohol on rat liver. ( McDonald, GS, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (73.47) | 18.7374 |
| 1990's | 1 (2.04) | 18.2507 |
| 2000's | 1 (2.04) | 29.6817 |
| 2010's | 8 (16.33) | 24.3611 |
| 2020's | 3 (6.12) | 2.80 |
| Authors | Studies |
|---|---|
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Kenna, JG | 1 |
| Stahl, S | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Ren, Z | 3 |
| Chen, S | 3 |
| Qin, X | 1 |
| Li, F | 1 |
| Guo, L | 3 |
| Seo, JE | 1 |
| Guo, X | 1 |
| Li, D | 1 |
| Ning, B | 1 |
| Pak, S | 1 |
| Schumacher, JD | 1 |
| Guo, GL | 1 |
| Ashrafian, H | 1 |
| Horowitz, JD | 2 |
| Frenneaux, MP | 1 |
| Dawes, P | 1 |
| Moulder, C | 1 |
| Morgan, MY | 1 |
| Reshef, R | 1 |
| Shah, RR | 1 |
| Oates, NS | 1 |
| Smith, RL | 1 |
| Sherlock, S | 1 |
| Pounder, DJ | 1 |
| Valerdiz Casasola, S | 1 |
| Linares Rodríguez, A | 1 |
| Recarte Alvarez, J | 1 |
| Rodrigo Sáez, L | 1 |
| Paliard, P | 3 |
| Evreux, JC | 1 |
| Léry, N | 1 |
| Seeff, LB | 1 |
| White, HD | 1 |
| Goble, AJ | 1 |
| Vic, P | 1 |
| Sablier, G | 1 |
| François, C | 1 |
| Michel, H | 1 |
| Sentein, P | 1 |
| Boucard, M | 1 |
| Roberts, RK | 1 |
| Cohn, D | 1 |
| Petroff, V | 1 |
| Seneviratne, B | 1 |
| Poupon, R | 4 |
| Rosensztajn, L | 1 |
| Prudhomme de Saint-Maur, P | 1 |
| Lageron, A | 6 |
| Gombeau, T | 1 |
| Darnis, F | 2 |
| Atkinson, AB | 1 |
| McAreavey, D | 1 |
| Trope, G | 1 |
| Caruzzo, C | 1 |
| Troni, W | 1 |
| Cremo, R | 1 |
| Long, JP | 1 |
| Fitzgerald, O | 1 |
| Maurer, BJ | 1 |
| de Saint-Maur, PP | 2 |
| Lévy, VG | 2 |
| Kopelman, P | 1 |
| Morgan, PG | 1 |
| Serot, JM | 1 |
| Floquet, A | 1 |
| Penin, F | 1 |
| Cuny, G | 1 |
| Grignon, G | 1 |
| Hauw, JJ | 1 |
| Singer, B | 1 |
| Lecomte, D | 2 |
| Pollet, S | 1 |
| Pessayre, D | 1 |
| Bichara, M | 1 |
| Degott, C | 1 |
| Potet, F | 1 |
| Benhamou, JP | 1 |
| Feldmann, G | 1 |
| Bertrand, L | 1 |
| Baldet, P | 1 |
| Blanc, F | 1 |
| Puyeo, J | 1 |
| Lewis, D | 1 |
| Wainwright, HC | 1 |
| Kew, MC | 1 |
| Zwi, S | 1 |
| Isaacson, C | 1 |
| Roche, J | 1 |
| Fournet, J | 1 |
| Meullenet, J | 1 |
| Faure, H | 1 |
| Massot, C | 1 |
| McDonald, GS | 1 |
| Beaugrand, M | 3 |
| Callard, P | 3 |
| Forbes, GB | 1 |
| Rake, MO | 1 |
| Taylor, DJ | 1 |
| Chousterman, M | 1 |
| Camilleri, JP | 1 |
| Petite, J | 1 |
| Ferrier, JP | 2 |
| Cousteau, JP | 1 |
| Singlas, E | 1 |
| Assan, R | 1 |
| Bournerias, F | 1 |
| Margent, P | 1 |
| Goulon, M | 1 |
| Vitrey, D | 1 |
| Fournier, G | 1 |
| Belhadjali, J | 1 |
| Patricot, L | 1 |
| Berger, F | 1 |
| Herne, N | 1 |
| Raillat, A | 1 |
| Marion, J | 1 |
| Le Gall, F | 1 |
| Chagnon, A | 1 |
| Pelletier, M | 1 |
| Lambert, R | 1 |
| Bory, R | 1 |
| Satz, N | 1 |
| Täuber, M | 1 |
| Streuli, R | 1 |
| Spycher, MA | 1 |
| Maurer, R | 1 |
| Valmalle, R | 1 |
| Bacq, Y | 1 |
| Furet, Y | 1 |
| Dorval, E | 1 |
| Barbieux, JP | 1 |
| Metman, EH | 1 |
| Lauterburg, BH | 1 |
| Rees, JR | 1 |
| Abaza, A | 1 |
| Cattan, D | 1 |
| Aziza, C | 1 |
| Pappo, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Metabolic Support With Perhexiline to Protect Myocardium Undergoing Coronary Artery Surgery[NCT00845364] | Phase 2/Phase 3 | 290 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| Myocardial Protection With Perhexiline in Left Ventricular Hypertrophy[NCT00989508] | Phase 2/Phase 3 | 220 participants (Anticipated) | Interventional | 2009-10-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for perhexiline and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Mechanistic review of drug-induced steatohepatitis.
Topics: Amiodarone; Animals; Camptothecin; Chemical and Drug Induced Liver Injury; Disease Models, Animal; F | 2015 |
Perhexiline.
Topics: Angina Pectoris; Animals; Aortic Valve Stenosis; Calcium Channel Blockers; Carnitine O-Palmitoyltran | 2007 |
Perhexiline.
Topics: Angina Pectoris; Animals; Aortic Valve Stenosis; Calcium Channel Blockers; Carnitine O-Palmitoyltran | 2007 |
Perhexiline.
Topics: Angina Pectoris; Animals; Aortic Valve Stenosis; Calcium Channel Blockers; Carnitine O-Palmitoyltran | 2007 |
Perhexiline.
Topics: Angina Pectoris; Animals; Aortic Valve Stenosis; Calcium Channel Blockers; Carnitine O-Palmitoyltran | 2007 |
[Hepatitis caused by drugs. 5].
Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Deoxyepinephrine; Erythromycin; Gold; Humans | 1982 |
Drug-induced chronic liver disease, with emphasis on chronic active hepatitis.
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Chlorpromazine; Dantrolene; Diagnosis, Differential; | 1981 |
[Cirrhogenic hepatitis due to perhexiline maleate: general review based upon one new case with ultrastructural study (author's transl)].
Topics: Aged; Angina Pectoris; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Hepa | 1978 |
[Drug damage to the liver: role of reactive metabolites and pharmacokinetics].
Topics: Acetaminophen; Amiodarone; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adv | 1985 |
2 trials available for perhexiline and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
[Drug monitoring and liver diseases induced by perhexiline maleate].
Topics: Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; France; Humans; Perhexiline; Piper | 1981 |
The action of perhexiline maleate in patients with angina and its effect on liver function.
Topics: Adult; Aged; Angina Pectoris; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Dose | 1973 |
40 other studies available for perhexiline and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Study of the roles of cytochrome P450 (CYPs) in the metabolism and cytotoxicity of perhexiline.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome | 2022 |
Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline.
Topics: Apoptosis; Cardiovascular Agents; Cell Line; Chemical and Drug Induced Liver Injury; Hepatocytes; Hu | 2020 |
A mechanism of perhexiline's cytotoxicity in hepatic cells involves endoplasmic reticulum stress and p38 signaling pathway.
Topics: Activating Transcription Factor 4; Apoptosis; Cell Line, Tumor; Chemical and Drug Induced Liver Inju | 2021 |
Perhexiline hepatitis and HLA-B8.
Topics: Angina Pectoris; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Genes; Hep | 1982 |
Impaired oxidation of debrisoquine in patients with perhexiline liver injury.
Topics: Adolescent; Adult; Aged; Angina Pectoris; Chemical and Drug Induced Liver Injury; Chronic Disease; D | 1984 |
Problems in the necropsy diagnosis of alcoholic liver disease.
Topics: Acetaminophen; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Diabetes Mellitus; D | 1984 |
Liver disease induced by perhexiline maleate.
Topics: Chemical and Drug Induced Liver Injury; Perhexiline; Piperidines | 1982 |
[Comparative hepatic toxicity of perhexiline maleate and griseofulvin in mice].
Topics: Animals; Chemical and Drug Induced Liver Injury; Griseofulvin; Liver; Male; Mice; Perhexiline; Piper | 1981 |
Liver disease induced by perhexiline maleate.
Topics: Angina Pectoris; Chemical and Drug Induced Liver Injury; Humans; Liver; Liver Cirrhosis, Alcoholic; | 1981 |
Perhexiline maleate-associated hepatic injury prevalence and characteristics.
Topics: Adult; Aged; Angina Pectoris; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Female; France | 1980 |
Papilloedema and hepatic dysfunction apparently induced by perhexiline maleate (Pexid).
Topics: Angina Pectoris; Chemical and Drug Induced Liver Injury; Humans; Male; Middle Aged; Papilledema; Per | 1980 |
Toxic polyneuritis and toxic hepatitis related to long-term perhexiline maleate therapy.
Topics: Angina Pectoris; Chemical and Drug Induced Liver Injury; Humans; Male; Middle Aged; Perhexiline; Pip | 1980 |
Hepatotoxicity following treatment with perhexiline maleate.
Topics: Aged; Angina Pectoris; Chemical and Drug Induced Liver Injury; Female; Humans; Male; Middle Aged; Pe | 1980 |
Liver ganglioside storage after perhexiline maleate.
Topics: Aged; Chemical and Drug Induced Liver Injury; Coronary Disease; Cytoplasm; Gangliosides; Gangliosido | 1977 |
Liver damage after perhexiline maleate.
Topics: Angina Pectoris; Chemical and Drug Induced Liver Injury; Humans; Male; Middle Aged; Perhexiline; Pip | 1977 |
[Ultrastructural study of the liver after treatment with perhexiline maleate].
Topics: Aged; Angina Pectoris; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Perhexiline; P | 1977 |
[Diffuse polymorphous inclusions in a patient treated with perhexiline maleate (author's transl)].
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Humans; Inclusion Bodies; Lipidoses; Liver; Male; Mi | 1978 |
Perhexiline maleate-induced cirrhosis.
Topics: Aged; Angina Pectoris; Chemical and Drug Induced Liver Injury; Cytoplasmic Granules; Female; Hepatic | 1979 |
Liver damage associated with perhexiline maleate.
Topics: Aged; Angina Pectoris; Chemical and Drug Induced Liver Injury; Humans; Liver; Male; Middle Aged; Per | 1979 |
[Acute hepatic failure due to perhexiline maleate].
Topics: Aged; Angina Pectoris; Chemical and Drug Induced Liver Injury; Humans; Liver Cirrhosis; Male; Perhex | 1979 |
The effects of perhexiline maleate (Pexid) and alcohol on rat liver.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Synergism; Ethanol; Liver; Liver Diseases; Mal | 1979 |
[The liver and perhexiline maleate].
Topics: Chemical and Drug Induced Liver Injury; Humans; Liver; Perhexiline; Piperidines | 1979 |
[Histoenzymologic modifications induced by perhexiline maleate in human liver].
Topics: Aged; Chemical and Drug Induced Liver Injury; Humans; Liver; Middle Aged; Perhexiline; Piperidines | 1979 |
Liver damage due to perhexiline maleate.
Topics: Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Hepatitis, Alcoholic; Humans; Liver | 1979 |
[Hepatitis due to perhexiline maleate. Development of cirrhosis after interruption of the drug. Report of two cases (author's transl)].
Topics: Aged; Chemical and Drug Induced Liver Injury; Humans; Liver; Liver Cirrhosis; Male; Middle Aged; Per | 1977 |
[Can one give perhexiline to diabetics?].
Topics: Angina Pectoris; Body Weight; Chemical and Drug Induced Liver Injury; Diabetes Complications; Diabet | 1978 |
[Hepatitis and acute renal failure following halothane anaesthesia in a patient treated with perhexiline maleate (author's transl)].
Topics: Acute Kidney Injury; Aged; Angina Pectoris; Chemical and Drug Induced Liver Injury; Drug Synergism; | 1978 |
Perhexiline maleate-induced hepatitis.
Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Male; Middle Aged; Perhexiline; | 1978 |
[Hepatic lesions due to perhexiline maleate (author's transl)].
Topics: Aged; Chemical and Drug Induced Liver Injury; Coronary Disease; Female; Humans; Liver; Male; Middle | 1978 |
[Subacute toxic hepatitis and perhexiline maleates].
Topics: Acute Disease; Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Male; Middle Age | 1976 |
[Letter: Subacute toxic hepatitis following perhexiline maleate therapy].
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Female; Humans; Maleates; Middle Aged; Perhex | 1976 |
Perhexiline maleate-induced hepatitis.
Topics: Angina Pectoris; Biopsy; Chemical and Drug Induced Liver Injury; Debrisoquin; Humans; Liver; Male; M | 1991 |
[Fatal acute hepatitis during treatment with perhexiline maleate and bezafibrate].
Topics: Aged; Bezafibrate; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Humans; Male; | 1989 |
[Letter: Secondary but reversible effects of perhexilin administration].
Topics: Chemical and Drug Induced Liver Injury; Coronary Disease; Female; Humans; Middle Aged; Perhexiline; | 1973 |