perfluorooctanoic acid has been researched along with Body Weight in 64 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 8 (12.50) | 18.7374 |
1990's | 8 (12.50) | 18.2507 |
2000's | 24 (37.50) | 29.6817 |
2010's | 20 (31.25) | 24.3611 |
2020's | 4 (6.25) | 2.80 |
Authors | Studies |
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Attema, B; Hooiveld, GJEJ; Janssen, AWF; Kersten, S; Rijkers, D; van Schothorst, EM | 1 |
Heiger-Bernays, W; Nielsen, G; Oliver, J; Puckett, H; Schlezinger, JJ; Webster, TF | 1 |
Boston, C; Heiger-Bernays, W; Hyötyläinen, T; Oliver, J; Puckett, H; Schlezinger, JJ; Sinioja, T; Webster, TF | 1 |
Airaksinen, R; Berger, U; Cousins, IT; Karvonen, AM; Kiviranta, H; Koponen, J; Pekkanen, J; Vestergren, R; Winkens, K | 1 |
Du, G; Hu, J; Huang, Z; Lu, C; Wang, X; Wu, D; Yu, M | 1 |
Gong, X; Guan, S; Li, D; Wang, X; Zhang, L; Zhang, Y | 1 |
Jia, W; Li, Q; Qiao, P; Sun, X; Tan, X; Xie, G; Zhong, W; Zhou, Z | 1 |
Haug, LS; Hetland, RB; Ngo, HT; Sabaredzovic, A; Steffensen, IL | 1 |
Cummings, CA; Fenton, SE; Filgo, AJ; Hoenerhoff, MJ; Kissling, GE; Quist, EM | 1 |
Bastos Sales, L; Dollé, ME; Håkansson, H; Herlin, M; Legler, J; van der Ven, LT; van Esterik, JC | 1 |
Giesy, JP; Jin, L; Li, K; Li, M; Wei, S; Xie, Y; Yang, J; Yu, H; Yu, N; Zhang, X | 1 |
Domazet, SL; Grøntved, A; Jensen, TK; Nielsen, F; Timmermann, AG | 1 |
Fenton, SE; Goulding, DR; Harry, GJ; McBride, SJ; White, SS | 1 |
Everds, NE; Frame, SR; Hoban, D; Loveless, SE; Sykes, G | 1 |
Cui, L; Fu, JJ; Jiang, GB; Liao, CY; Zhou, QF | 1 |
Eriksson, P; Johansson, N; Viberg, H | 1 |
Copeland, CB; DeWitt, JC; Luebke, RW | 1 |
Delinsky, AD; Fenton, SE; Hines, EP; Lindstrom, AB; Nakayama, SF; Petropoulou, SE; Reiner, JL; Stanko, JP; Strynar, MJ; White, SS | 1 |
Barton, HA; Rodriguez, CE; Setzer, RW | 1 |
Fenton, SE; Gibbs-Flournoy, EA; Hines, EP; Lau, C; Stanko, JP; White, SS | 1 |
Abedi-Valugerdi, M; Bogdanska, J; Butenhoff, JL; Chang, SC; DePierre, JW; Ehresman, DJ; Nelson, BD; Qazi, MR; Xia, Z | 1 |
Aoyama, T; Gonzalez, FJ; Hayashi, Y; Ito, Y; Kono, Y; Li, Y; Naito, H; Nakajima, T; Nakamura, T; Ramdhan, DH; Yanagiba, Y | 1 |
Hatch, EE; Nelson, JW; Webster, TF | 1 |
Butenhoff, JL; Chang, SC; Elcombe, BM; Elcombe, CR; Farrar, DG; Foster, JR; Jung, R; Kennedy, GL | 1 |
Abedel-Latif, M; El-Nasser, MA; Sato, I; Tsuda, S; Tsukuba, C; Yahia, D; Yoshida, M | 1 |
Cho, NK; Kim, DH; Kim, JH; Lee, CH; Lee, CK; Lee, JT; Son, BC; Suh, CH | 1 |
Fenton, SE; Helfant, L; Macon, MB; Stanko, JP; Strynar, MJ; Tatum-Gibbs, K; Villanueva, LR; White, SS; Zehr, RD | 1 |
Andersen, ME; Butenhoff, JL; Campbell, JL; Clewell, HJ; Loccisano, AE | 2 |
Butenhoff, JL; Chang, SC; Kennedy, GL; Olsen, GW | 1 |
Abedi-Valugerdi, M; DePierre, JW; Nelson, BD; Qazi, MR | 1 |
Calafat, AM; Christensen, KY; Holmes, A; Maisonet, M; Marcus, M; McGeehin, MA; Terrell, ML | 1 |
Butenhoff, J; Costa, G; Elcombe, C; Farrar, D; Hansen, K; Iwai, H; Jung, R; Kennedy, G; Lieder, P; Olsen, G; Thomford, P | 1 |
Butenhoff, JL; Frame, SR; Kennedy, GL; O'Connor, JC; York, RG | 1 |
Butenhoff, JL; Gaylor, DW; Mandel, JH; Moore, JA; Olsen, GW; Rodricks, J; Zobel, LR | 1 |
Butenhoff, JL; Gorman, GS; Hansen, KJ; Hinderliter, PM; Jung, R; Kennedy, GL; Lieder, PH; Noker, PE; Thomford, PJ | 1 |
Butenhoff, JL; Kennedy, GL; Palazzolo, MJ; Perkins, RG | 1 |
Butenhoff, JL; Gannon, SA; Hinderliter, PM; Kennedy, GL; Mylchreest, E | 1 |
Iwai, H; Yamashita, K | 1 |
Butenhoff, JL; Han, X; Hinderliter, PM; Kennedy, GL | 1 |
Kawashima, Y; Kudo, N; Mitsumoto, A; Suzuki-Nakajima, E | 1 |
Henderson, WM; Smith, MA | 1 |
Abbott, BD; Bryant, XA; Calafat, AM; Das, KP; Fenton, SE; Kuklenyik, Z; Lau, CS; Schmid, JE; Thibodeaux, J; White, SS; Wolf, CJ | 1 |
Calafat, AM; Fenton, SE; Helfant, L; Kuklenyik, Z; Lindstrom, AB; Strynar, MJ; Thibodeaux, JR; Villanueva, L; White, SS; Wood, C; Zehr, RD | 1 |
Anderson, SE; Fairley, KJ; Kearns, S; Meade, B; Purdy, R | 1 |
Iannucci, A; Scialli, AR; Turim, J | 1 |
Andersen, ME; Olson, CT | 1 |
Griffith, FD; Long, JE | 1 |
Kawashima, Y; Kobayashi, H; Kozuka, H; Miura, H | 1 |
Kawashima, Y; Kozuka, H; Sato, M; Suzuki, S; Suzuki, Y | 1 |
Chinje, E; Diaz, MJ; George, M; Gibson, G; Jarnot, B; Kentish, P | 1 |
Andersson, K; De Pierre, JW; Olsson, U; Sundberg, C | 1 |
Goecke-Flora, CM; Reo, NV | 1 |
Kawashima, Y; Kudo, N | 1 |
DePierre, JW; Eriksson, AM; Nelson, BD; Xie, Y; Yang, Q | 1 |
Andersson, K; DePierre, JW; Lundgren, B; Permadi, H | 1 |
Cook, JC; Frame, SR; Hurtt, ME; Murray, SM | 1 |
Chromey, NC; Kennedy, GL; Kinney, LA | 1 |
Gorgas, K; Hartl, FU; Heinemann, P; Just, WW; Salzer, M; Schimassek, H | 1 |
Gillies, PJ; Lee, KP; Pastoor, TP; Perri, MA | 1 |
Kennedy, GL | 2 |
Barnes, JR; Brittelli, MR; Chen, HC; Hall, GT; Kennedy, GL | 1 |
64 other study(ies) available for perfluorooctanoic acid and Body Weight
Article | Year |
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Exposure to low-dose perfluorooctanoic acid promotes hepatic steatosis and disrupts the hepatic transcriptome in mice.
Topics: Animals; Body Weight; Fluorocarbons; Glucose; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; PPAR alpha; Transcriptome; Triglycerides | 2022 |
Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPARα mice fed an American diet.
Topics: Animals; Body Weight; Caprylates; Cholesterol; Constitutive Androstane Receptor; Diet, Western; Female; Fluorocarbons; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Size; PPAR alpha; Receptors, Cytoplasmic and Nuclear; Sex Characteristics; Transcriptome; Water Pollutants, Chemical | 2020 |
Toxicology and carcinogenesis studies of perfluorooctanoic acid administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised).
Topics: Adenocarcinoma; Adenoma; Animals; Body Weight; Caprylates; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Dose-Response Relationship, Drug; Drug Administration Routes; Female; Fluorocarbons; Liver Neoplasms; Male; Pancreatic Neoplasms; Rats; Rats, Sprague-Dawley; Survival Rate | 2020 |
Perfluorooctanoic acid induces liver and serum dyslipidemia in humanized PPARα mice fed an American diet.
Topics: Animals; Body Weight; Caprylates; Diet, Western; Dyslipidemias; Female; Fluorocarbons; Gene Expression; Genotype; Lipidomics; Liver; Male; Mice, Transgenic; Organ Size; PPAR alpha; Triglycerides; United States | 2021 |
Longitudinal trends of per- and polyfluoroalkyl substances in children's serum.
Topics: Alkanesulfonic Acids; Body Weight; Breast Feeding; Caprylates; Child; Child, Preschool; Dust; Environmental Pollutants; Female; Fluorocarbons; Humans; Infant; Male; Sulfonic Acids | 2018 |
Neonatal and juvenile exposure to perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS): Advance puberty onset and kisspeptin system disturbance in female rats.
Topics: Alkanesulfonic Acids; Animals; Body Weight; Caprylates; Down-Regulation; Estradiol; Estrogen Receptor alpha; Estrous Cycle; Female; Fluorocarbons; Hypothalamus; Kisspeptins; Luteinizing Hormone; Ovarian Follicle; Rats; Receptors, Kisspeptin-1; RNA, Messenger; Sexual Maturation | 2019 |
Maternal exposure to perfluorooctanoic acid (PFOA) causes liver toxicity through PPAR-α pathway and lowered histone acetylation in female offspring mice.
Topics: Acetylation; Animals; Body Weight; Caprylates; Female; Fluorocarbons; Histones; Lipid Metabolism; Liver; Maternal Exposure; Mice; Necrosis; Oxidative Stress; PPAR alpha; Pregnancy; Prenatal Exposure Delayed Effects; Random Allocation | 2019 |
High fat diet feeding exaggerates perfluorooctanoic acid-induced liver injury in mice via modulating multiple metabolic pathways.
Topics: Adipose Tissue, White; Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Caprylates; Diet, High-Fat; Fatty Acids; Fatty Liver; Fluorocarbons; Gene Expression Profiling; Gene Expression Regulation; Hepatocytes; Inflammation; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Necrosis; Organ Size; Triglycerides | 2013 |
In utero exposure to perfluorooctanoate (PFOA) or perfluorooctane sulfonate (PFOS) did not increase body weight or intestinal tumorigenesis in multiple intestinal neoplasia (Min/+) mice.
Topics: Alkanesulfonic Acids; Animals; Blood Glucose; Body Weight; Caprylates; Carcinogenesis; Eating; Female; Fluorocarbons; Intestinal Neoplasms; Liver; Male; Mice; Mice, Inbred C57BL; Obesity; Organ Size; Pregnancy; Reproduction; Spleen | 2014 |
Hepatic Mitochondrial Alteration in CD-1 Mice Associated with Prenatal Exposures to Low Doses of Perfluorooctanoic Acid (PFOA).
Topics: Animals; Body Weight; Caprylates; Dose-Response Relationship, Drug; Female; Fluorocarbons; Hepatocytes; Liver; Mice; Mitochondria, Liver; PPAR alpha; Pregnancy; Prenatal Exposure Delayed Effects | 2015 |
Programming of metabolic effects in C57BL/6JxFVB mice by in utero and lactational exposure to perfluorooctanoic acid.
Topics: Animals; Body Weight; Caprylates; Cholesterol; Diet, High-Fat; Dose-Response Relationship, Drug; Female; Fluorocarbons; Lactation; Male; Maternal Exposure; Mice, Inbred C57BL; Mice, Inbred Strains; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects | 2016 |
Effects of Perfluorooctanoic Acid on Metabolic Profiles in Brain and Liver of Mouse Revealed by a High-throughput Targeted Metabolomics Approach.
Topics: Animals; Body Weight; Brain Chemistry; Caprylates; Environmental Pollutants; Fluorocarbons; High-Throughput Screening Assays; Lipid Metabolism; Liver; Male; Metabolomics; Mice; Mice, Inbred BALB C; Neurotransmitter Agents; Organ Specificity | 2016 |
Longitudinal Associations of Exposure to Perfluoroalkylated Substances in Childhood and Adolescence and Indicators of Adiposity and Glucose Metabolism 6 and 12 Years Later: The European Youth Heart Study.
Topics: Adiposity; Adolescent; Alkanesulfonic Acids; Blood Glucose; Body Mass Index; Body Weight; Caprylates; Child; Cross-Sectional Studies; Environmental Exposure; Europe; Female; Fluorocarbons; Humans; Insulin; Insulin Resistance; Longitudinal Studies; Male; Pediatric Obesity; Prospective Studies; Skinfold Thickness; Socioeconomic Factors; Surveys and Questionnaires; Triglycerides; Waist Circumference; Young Adult | 2016 |
Gestational exposure to perfluorooctanoic acid (PFOA): Alterations in motor related behaviors.
Topics: Analysis of Variance; Animals; Body Weight; Caprylates; Cohort Studies; Dose-Response Relationship, Drug; Environmental Pollutants; Female; Fluorocarbons; Gestational Age; Mice; Motor Disorders; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Reflex, Startle; Running | 2017 |
Evaluation of the immune system in rats and mice administered linear ammonium perfluorooctanoate.
Topics: Animals; Blood Cell Count; Body Weight; Caprylates; Corticosterone; Dose-Response Relationship, Drug; Fluorocarbons; Immune System; Immunoglobulin M; Lipids; Liver; Male; Mice; Mice, Inbred ICR; No-Observed-Adverse-Effect Level; Organ Size; PPAR alpha; Rats; Rats, Sprague-Dawley; Spleen; Thymus Gland | 2008 |
Studies on the toxicological effects of PFOA and PFOS on rats using histological observation and chemical analysis.
Topics: Alkanesulfonic Acids; Animals; Behavior, Animal; Body Weight; Caprylates; Dose-Response Relationship, Drug; Environmental Pollutants; Fluorocarbons; Kidney; Liver; Lung; Male; Organ Specificity; Rats; Rats, Sprague-Dawley; Tissue Distribution; Toxicity Tests, Chronic | 2009 |
Neonatal exposure to PFOS and PFOA in mice results in changes in proteins which are important for neuronal growth and synaptogenesis in the developing brain.
Topics: Alkanesulfonic Acids; Animals; Animals, Newborn; Body Weight; Brain; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Caprylates; Female; Fluorocarbons; GAP-43 Protein; Male; Mice; Nerve Tissue Proteins; Neurons; Pregnancy; Synapses; Synaptophysin; tau Proteins | 2009 |
Suppression of humoral immunity by perfluorooctanoic acid is independent of elevated serum corticosterone concentration in mice.
Topics: Adrenalectomy; Analysis of Variance; Animals; Antibody Formation; Blood Chemical Analysis; Body Weight; Caprylates; Corticosterone; Female; Fluorocarbons; Immune Tolerance; Immunoglobulin M; Immunosuppressive Agents; Mice; Mice, Inbred C57BL | 2009 |
Analysis of PFOA in dosed CD-1 mice. Part 2. Disposition of PFOA in tissues and fluids from pregnant and lactating mice and their pups.
Topics: Amniotic Fluid; Animals; Animals, Newborn; Blood Chemical Analysis; Body Weight; Caprylates; Dose-Response Relationship, Drug; Environmental Pollutants; Female; Fluorocarbons; Lactation; Maternal Exposure; Mice; Mice, Inbred Strains; Milk; Pregnancy; Prenatal Exposure Delayed Effects; Urinalysis | 2009 |
Pharmacokinetic modeling of perfluorooctanoic acid during gestation and lactation in the mouse.
Topics: Animals; Area Under Curve; Body Weight; Caprylates; Computer Simulation; Dose-Response Relationship, Drug; Environmental Pollutants; Female; Fluorocarbons; Gestational Age; Half-Life; Lactation; Metabolic Clearance Rate; Mice; Mice, Inbred Strains; Models, Statistical; Predictive Value of Tests; Pregnancy | 2009 |
Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: Low doses induce elevated serum leptin and insulin, and overweight in mid-life.
Topics: Animals; Body Weight; Caprylates; Female; Fluorocarbons; Humans; Insulin; Leptin; Maternal Exposure; Mice; Organ Size; Ovariectomy; Overweight; Phenotype; Pregnancy; Prenatal Exposure Delayed Effects; Random Allocation | 2009 |
The atrophy and changes in the cellular compositions of the thymus and spleen observed in mice subjected to short-term exposure to perfluorooctanesulfonate are high-dose phenomena mediated in part by peroxisome proliferator-activated receptor-alpha (PPARa
Topics: Alkanesulfonic Acids; Animals; Atrophy; B-Lymphocytes; Body Weight; Caprylates; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Immunologic; Flow Cytometry; Fluorocarbons; Immunophenotyping; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Organ Size; PPAR alpha; Spleen; T-Lymphocytes; Thymus Gland | 2009 |
Microgram-order ammonium perfluorooctanoate may activate mouse peroxisome proliferator-activated receptor alpha, but not human PPARalpha.
Topics: Alanine Transaminase; Animals; Biotransformation; Blotting, Western; Body Weight; Caprylates; Cell Nucleus; CHO Cells; Cricetinae; Cricetulus; Female; Fluorocarbons; Gene Expression; Humans; Lipid Metabolism; Lipids; Male; Mice; Mice, Knockout; Organ Size; PPAR alpha; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Species Specificity | 2009 |
Exposure to polyfluoroalkyl chemicals and cholesterol, body weight, and insulin resistance in the general U.S. population.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alkanesulfonic Acids; Body Weight; Caprylates; Child; Cholesterol; Cross-Sectional Studies; Environmental Exposure; Female; Fluorocarbons; Humans; Insulin Resistance; Linear Models; Lipid Metabolism; Male; Middle Aged; Young Adult | 2010 |
Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARα and CAR/PXR.
Topics: Animals; Apoptosis; Body Weight; Caprylates; Cell Proliferation; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; DNA; Environmental Pollutants; Fluorocarbons; Hepatocytes; Hepatomegaly; Hypertrophy; Liver; Male; Organ Size; Peroxisomes; PPAR alpha; Pregnane X Receptor; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid | 2010 |
Effects of perfluorooctanoic acid (PFOA) exposure to pregnant mice on reproduction.
Topics: Animals; Body Weight; Caprylates; Female; Fetus; Fluorocarbons; Gravidity; Liver; Maternal Exposure; Mice; Mice, Inbred ICR; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects; Reproduction | 2010 |
Perfluorooctanoic acid-induced inhibition of placental prolactin-family hormone and fetal growth retardation in mice.
Topics: Animals; Body Weight; Caprylates; Cell Count; Cytokines; Female; Fetal Death; Fetal Growth Retardation; Fetal Weight; Fluorocarbons; Mice; Placenta; Placental Hormones; Placental Lactogen; Pregnancy; Pregnancy Proteins; Transcription Factor Pit-1; Transcription, Genetic; Trophoblasts | 2011 |
Prenatal perfluorooctanoic acid exposure in CD-1 mice: low-dose developmental effects and internal dosimetry.
Topics: Animals; Animals, Newborn; Body Weight; Caprylates; Dose-Response Relationship, Drug; Female; Fluorocarbons; Gestational Age; Liver; Male; Mammary Glands, Animal; Maternal Exposure; Mice; Mice, Inbred Strains; No-Observed-Adverse-Effect Level; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects; Sensitivity and Specificity | 2011 |
Comparison and evaluation of pharmacokinetics of PFOA and PFOS in the adult rat using a physiologically based pharmacokinetic model.
Topics: Alkanesulfonic Acids; Animals; Body Weight; Caprylates; Cardiac Output; Computer Simulation; Female; Fluorocarbons; Intestinal Mucosa; Intestines; Kidney; Liver; Male; Metabolic Clearance Rate; Models, Biological; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sex Factors; Time Factors; Tissue Distribution | 2012 |
Evaluation of placental and lactational pharmacokinetics of PFOA and PFOS in the pregnant, lactating, fetal and neonatal rat using a physiologically based pharmacokinetic model.
Topics: Aging; Alkanesulfonic Acids; Animals; Animals, Newborn; Body Weight; Caprylates; Computer Simulation; Dose-Response Relationship, Drug; Female; Fetal Blood; Fluorocarbons; Gestational Age; Lactation; Liver; Maternal Exposure; Maternal-Fetal Exchange; Milk; Models, Biological; Placenta; Pregnancy; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Tissue Distribution | 2012 |
Chronic dietary toxicity and carcinogenicity study with ammonium perfluorooctanoate in Sprague-Dawley rats.
Topics: Animals; Body Weight; Caprylates; Carcinogenicity Tests; Diet; Female; Fluorocarbons; Liver; Male; Organ Size; Rats; Rats, Sprague-Dawley; Survival Rate | 2012 |
High-dose dietary exposure of mice to perfluorooctanoate or perfluorooctane sulfonate exerts toxic effects on myeloid and B-lymphoid cells in the bone marrow and these effects are partially dependent on reduced food consumption.
Topics: Alkanesulfonic Acids; Animals; B-Lymphocytes; Body Weight; Bone Marrow Cells; Caprylates; Dose-Response Relationship, Drug; Feeding Behavior; Flow Cytometry; Fluorocarbons; Male; Mice; Mice, Inbred C57BL | 2012 |
Maternal concentrations of polyfluoroalkyl compounds during pregnancy and fetal and postnatal growth in British girls.
Topics: Adolescent; Age Factors; Alkanesulfonic Acids; Birth Weight; Body Weight; Caprylates; Child; Cohort Studies; England; Environmental Monitoring; Environmental Pollutants; Female; Fetal Development; Fluorocarbons; Gestational Age; Humans; Infant; Infant, Newborn; Longitudinal Studies; Maternal Exposure; Multivariate Analysis; Pregnancy; Prenatal Exposure Delayed Effects; Regression Analysis; Sulfonic Acids | 2012 |
Toxicity of ammonium perfluorooctanoate in male cynomolgus monkeys after oral dosing for 6 months.
Topics: Acyl Coenzyme A; Animals; Bilirubin; Body Weight; Caprylates; Cell Division; Cholecystokinin; DNA; DNA Replication; Estradiol; Fluorocarbons; Hormones; Liver; Macaca fascicularis; Male; Organ Size; Pancreas; Peroxisome Proliferators; Rats; Subcellular Fractions; Testis | 2002 |
The reproductive toxicology of ammonium perfluorooctanoate (APFO) in the rat.
Topics: Animals; Body Weight; Caprylates; Dose-Response Relationship, Drug; Eating; Female; Fluorocarbons; Growth; Litter Size; Male; Organ Size; Pregnancy; Rats; Rats, Sprague-Dawley; Reproduction; Sexual Maturation; Surface-Active Agents; Survival Analysis | 2004 |
Characterization of risk for general population exposure to perfluorooctanoate.
Topics: Adult; Aged; Animals; Animals, Newborn; Area Under Curve; Body Weight; Brain; Caprylates; Child; Dose-Response Relationship, Drug; Environmental Exposure; Female; Fluorocarbons; Half-Life; Haplorhini; Humans; Leydig Cell Tumor; Liver; Male; Models, Biological; Organ Size; Pregnancy; Rats; Risk Assessment; Testicular Neoplasms; Toxicity Tests | 2004 |
Pharmacokinetics of perfluorooctanoate in cynomolgus monkeys.
Topics: Animals; Body Weight; Caprylates; Data Interpretation, Statistical; Feces; Female; Fluorocarbons; Half-Life; Injections, Intravenous; Liver; Macaca fascicularis; Male; Quality Control; Reference Standards | 2004 |
13-week dietary toxicity study of ammonium perfluorooctanoate (APFO) in male rats.
Topics: Animals; Body Weight; Caprylates; Diet; Dose-Response Relationship, Drug; Estradiol; Fluorocarbons; Liver; Male; Organ Size; Oxidoreductases; Rats; Testosterone | 2004 |
Perfluorooctanoate: Placental and lactational transport pharmacokinetics in rats.
Topics: Animals; Biotransformation; Body Weight; Caprylates; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Fetus; Fluorocarbons; Lactation; Litter Size; Mass Spectrometry; Maternal-Fetal Exchange; Milk; Placenta; Pregnancy; Rats | 2005 |
A fourteen-day repeated dose oral toxicity study of APFO in rats.
Topics: Animals; Antibodies, Monoclonal; Blood Cell Count; Blood Chemical Analysis; Blood Glucose; Body Weight; Caprylates; Cholesterol; Fluorocarbons; Immunity, Cellular; Lipid Metabolism; Liver; Lymphocyte Count; Lymphocyte Subsets; Male; Organ Size; Peroxisomes; Phospholipids; Rats; Triglycerides | 2006 |
Age effect on perfluorooctanoate (PFOA) plasma concentration in post-weaning rats following oral gavage with ammonium perfluorooctanoate (APFO).
Topics: Administration, Oral; Age Factors; Animals; Body Weight; Caprylates; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Fluorocarbons; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Sex Factors; Surface-Active Agents; Weaning | 2006 |
Responses of the liver to perfluorinated fatty acids with different carbon chain length in male and female mice:in relation to induction of hepatomegaly, peroxisomal beta-oxidation and microsomal 1-acylglycerophosphocholine acyltransferase.
Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Animals; Body Weight; Caproates; Caprylates; Female; Fluorocarbons; Hepatomegaly; Liver; Male; Mice; Microsomes, Liver; Organ Size; Oxidation-Reduction; Peroxisomes; Sex Characteristics; Structure-Activity Relationship | 2006 |
Perfluorooctanoic acid and perfluorononanoic acid in fetal and neonatal mice following in utero exposure to 8-2 fluorotelomer alcohol.
Topics: Animals; Animals, Newborn; Body Burden; Body Weight; Caprylates; Environmental Pollutants; Fatty Alcohols; Female; Fluorocarbons; Gestational Age; Liver; Mice; Mice, Inbred Strains; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects; Tissue Distribution | 2007 |
Developmental toxicity of perfluorooctanoic acid in the CD-1 mouse after cross-foster and restricted gestational exposures.
Topics: Animals; Birth Weight; Body Weight; Caprylates; Environmental Pollutants; Female; Fluorocarbons; Gestational Age; Lactation; Litter Size; Male; Mice; Mice, Inbred Strains; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects | 2007 |
Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring.
Topics: Administration, Oral; Animals; Animals, Newborn; Body Weight; Caprylates; Cell Differentiation; Dose-Response Relationship, Drug; Environmental Pollutants; Female; Fluorocarbons; Gene Expression Regulation; Gestational Age; Liver; Mammary Glands, Animal; Maternal Exposure; Mice; Milk Proteins; Pregnancy; Prenatal Exposure Delayed Effects; RNA, Messenger; Time Factors | 2007 |
Exposure to the immunosuppressant, perfluorooctanoic acid, enhances the murine IgE and airway hyperreactivity response to ovalbumin.
Topics: Administration, Topical; Animals; Antigens; Asthma; Body Weight; Bronchial Hyperreactivity; Caprylates; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Fluorocarbons; Hypersensitivity; Immunoglobulin E; Immunosuppressive Agents; Lung; Mice; Mice, Inbred BALB C; Organ Size; Ovalbumin; Phenotype; Respiratory Hypersensitivity | 2007 |
Combining perfluoroalkane acid exposure levels for risk assessment.
Topics: Acids; Alkanes; Alkanesulfonic Acids; Animals; Animals, Newborn; Body Weight; Caprylates; Data Interpretation, Statistical; Decanoic Acids; Dose-Response Relationship, Drug; Embryonic Development; Environmental Exposure; Female; Fetal Development; Fluorocarbons; Male; Mice; Penis; Rats; Risk Assessment; Toxicity Tests | 2007 |
The acute toxicity of perfluorooctanoic and perfluorodecanoic acids in male rats and effects on tissue fatty acids.
Topics: Animals; Blood; Body Weight; Caprylates; Decanoic Acids; Fatty Acids; Feeding Behavior; Fluorocarbons; Liver; Male; Organ Size; Rats; Rats, Inbred F344; Testis; Time Factors | 1983 |
Animal toxicity studies with ammonium perfluorooctanoate.
Topics: Animals; Body Weight; Caprylates; Dose-Response Relationship, Drug; Female; Fluorocarbons; Haplorhini; Lethal Dose 50; Liver; Macaca mulatta; Male; Mice; Mutagens; Organ Size; Rabbits; Rats; Time Factors | 1980 |
Characterization of hepatic responses of rat to administration of perfluorooctanoic and perfluorodecanoic acids at low levels.
Topics: Analysis of Variance; Animals; Body Weight; Caprylates; Decanoic Acids; Diet; Fluorocarbons; Lipid Metabolism; Liver; Male; Organ Size; Rats; Rats, Wistar | 1995 |
Effects of prolonged administration of perfluorooctanoic acid on hepatic activities of enzymes which detoxify peroxide and xenobiotic in the rat.
Topics: Animals; Body Weight; Caprylates; Female; Fluorocarbons; Glutathione Peroxidase; Glutathione Transferase; Hydrogen Peroxide; Inactivation, Metabolic; Lipid Peroxidation; Liver; Male; Microbodies; Organ Size; Rats; Rats, Wistar; Sex Factors; Xenobiotics | 1994 |
Induction of cytochrome P4504A by the peroxisome proliferator perfluoro-n-octanoic acid.
Topics: Animals; Blotting, Western; Body Weight; Caprylates; Cytochrome P-450 Enzyme System; Enzyme Induction; Fluorocarbons; Isoenzymes; Kidney; Liver; Male; Microbodies; Microsomes, Liver; Mixed Function Oxygenases; Rats; Rats, Wistar | 1994 |
Further studies on the involvement of selenium in peroxisome proliferation in rat liver. Comparison of effects with clofibric acid and perfluorooctanoic acid and the pharmacokinetics of [14C]clofibrate.
Topics: Animals; Body Weight; Caprylates; Catalase; Clofibric Acid; Eating; Fatty Acids; Fluorocarbons; Liver; Microbodies; Mitochondria, Liver; Palmitoyl Coenzyme A; Rats; Selenium; Tissue Distribution | 1993 |
Influence of carbon chain length on the hepatic effects of perfluorinated fatty acids. A 19F- and 31P-NMR investigation.
Topics: Acyl-CoA Oxidase; Adenosine Triphosphate; Animal Feed; Animals; Bile; Body Weight; Caprylates; Cell Survival; Decanoic Acids; Eating; Fatty Acids; Fluorine; Fluorocarbons; Heptanoic Acids; Injections, Intraperitoneal; Liver; Magnetic Resonance Spectroscopy; Male; Microbodies; Oxidoreductases; Phosphorus Isotopes; Rats; Rats, Inbred F344; Time Factors | 1996 |
Fish oil-feeding prevents perfluorooctanoic acid-induced fatty liver in mice.
Topics: alpha-Linolenic Acid; Animals; Body Weight; Caprylates; Fatty Acids; Fatty Liver; Fish Oils; Fluorocarbons; Lipid Peroxidation; Liver; Male; Mice; Microbodies; Organ Size; Phospholipids; Plant Oils; Soybean Oil; Triglycerides | 1997 |
Further evidence for the involvement of inhibition of cell proliferation and development in thymic and splenic atrophy induced by the peroxisome proliferator perfluoroctanoic acid in mice.
Topics: Animals; Atrophy; Body Weight; Caprylates; Cell Cycle; Cell Division; Dose-Response Relationship, Drug; Fluorocarbons; Hypertrophy; Liver; Male; Mice; Mice, Inbred C57BL; Models, Animal; Organ Size; Peroxisome Proliferators; Peroxisomes; Phenotype; Spleen; Substance Withdrawal Syndrome; Thymus Gland; Time Factors | 2001 |
Effects of perfluoro fatty acids on xenobiotic-metabolizing enzymes, enzymes which detoxify reactive forms of oxygen and lipid peroxidation in mouse liver.
Topics: Animals; Body Weight; Caprylates; Cytochrome P-450 Enzyme System; Cytochromes b5; Decanoic Acids; Dose-Response Relationship, Drug; Enzyme Activation; Epoxide Hydrolases; Fluorocarbons; Liver; Male; Mice; Mice, Inbred C57BL; NAD(P)H Dehydrogenase (Quinone); NADPH-Ferrihemoprotein Reductase; Organ Size; Subcellular Fractions; Time Factors | 1992 |
Induction of Leydig cell adenomas by ammonium perfluorooctanoate: a possible endocrine-related mechanism.
Topics: Adenoma; Administration, Oral; Animals; Body Weight; Caprylates; Chorionic Gonadotropin; Dose-Response Relationship, Drug; Estradiol; Fluorocarbons; Leydig Cell Tumor; Liver; Male; Organ Size; Radioimmunoassay; Rats; Testicular Neoplasms; Testosterone | 1992 |
Acute inhalation toxicity of ammonium perfluorononanoate.
Topics: Administration, Inhalation; Air Pollutants; Animals; Body Weight; Caprylates; Fluorocarbons; Liver; Male; Organ Size; Rats | 1989 |
Biochemical effects and zonal heterogeneity of peroxisome proliferation induced by perfluorocarboxylic acids in rat liver.
Topics: Animals; Body Weight; Caprylates; Coenzyme A; Fluoroacetates; Fluorocarbons; Lipid Metabolism; Liver; Male; Membrane Proteins; Microbodies; Microscopy, Electron; Molecular Weight; Organ Size; Rats; Rats, Inbred Strains; Trifluoroacetic Acid | 1989 |
Biochemical and morphological studies of ammonium perfluorooctanoate-induced hepatomegaly and peroxisome proliferation.
Topics: Animals; Body Weight; Caprylates; DNA; Endoplasmic Reticulum; Fluorocarbons; Hepatomegaly; Lipids; Liver; Male; Microbodies; Microscopy, Electron; Microsomes; Mitochondria, Liver; Organ Size; Rats | 1987 |
Increase in mouse liver weight following feeding of ammonium perfluorooctanoate and related fluorochemicals.
Topics: Animals; Body Weight; Caprylates; Dose-Response Relationship, Drug; Female; Fluorocarbons; Liver; Male; Mice; Organ Size | 1987 |
Inhalation toxicity of ammonium perfluorooctanoate.
Topics: Administration, Inhalation; Animals; Body Weight; Caprylates; Cornea; Fluorides; Fluorocarbons; Liver; Necrosis; Organ Size; Pulmonary Edema; Rats | 1986 |
Dermal toxicity of ammonium perfluorooctanoate.
Topics: Administration, Topical; Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Caprylates; Erythema; Female; Fluorocarbons; Lethal Dose 50; Male; Organ Size; Rabbits; Rats; Sex Factors; Species Specificity | 1985 |