Page last updated: 2024-08-21

perfluorooctanoic acid and Body Weight

perfluorooctanoic acid has been researched along with Body Weight in 64 studies

Research

Studies (64)

TimeframeStudies, this research(%)All Research%
pre-19908 (12.50)18.7374
1990's8 (12.50)18.2507
2000's24 (37.50)29.6817
2010's20 (31.25)24.3611
2020's4 (6.25)2.80

Authors

AuthorsStudies
Attema, B; Hooiveld, GJEJ; Janssen, AWF; Kersten, S; Rijkers, D; van Schothorst, EM1
Heiger-Bernays, W; Nielsen, G; Oliver, J; Puckett, H; Schlezinger, JJ; Webster, TF1
Boston, C; Heiger-Bernays, W; Hyötyläinen, T; Oliver, J; Puckett, H; Schlezinger, JJ; Sinioja, T; Webster, TF1
Airaksinen, R; Berger, U; Cousins, IT; Karvonen, AM; Kiviranta, H; Koponen, J; Pekkanen, J; Vestergren, R; Winkens, K1
Du, G; Hu, J; Huang, Z; Lu, C; Wang, X; Wu, D; Yu, M1
Gong, X; Guan, S; Li, D; Wang, X; Zhang, L; Zhang, Y1
Jia, W; Li, Q; Qiao, P; Sun, X; Tan, X; Xie, G; Zhong, W; Zhou, Z1
Haug, LS; Hetland, RB; Ngo, HT; Sabaredzovic, A; Steffensen, IL1
Cummings, CA; Fenton, SE; Filgo, AJ; Hoenerhoff, MJ; Kissling, GE; Quist, EM1
Bastos Sales, L; Dollé, ME; Håkansson, H; Herlin, M; Legler, J; van der Ven, LT; van Esterik, JC1
Giesy, JP; Jin, L; Li, K; Li, M; Wei, S; Xie, Y; Yang, J; Yu, H; Yu, N; Zhang, X1
Domazet, SL; Grøntved, A; Jensen, TK; Nielsen, F; Timmermann, AG1
Fenton, SE; Goulding, DR; Harry, GJ; McBride, SJ; White, SS1
Everds, NE; Frame, SR; Hoban, D; Loveless, SE; Sykes, G1
Cui, L; Fu, JJ; Jiang, GB; Liao, CY; Zhou, QF1
Eriksson, P; Johansson, N; Viberg, H1
Copeland, CB; DeWitt, JC; Luebke, RW1
Delinsky, AD; Fenton, SE; Hines, EP; Lindstrom, AB; Nakayama, SF; Petropoulou, SE; Reiner, JL; Stanko, JP; Strynar, MJ; White, SS1
Barton, HA; Rodriguez, CE; Setzer, RW1
Fenton, SE; Gibbs-Flournoy, EA; Hines, EP; Lau, C; Stanko, JP; White, SS1
Abedi-Valugerdi, M; Bogdanska, J; Butenhoff, JL; Chang, SC; DePierre, JW; Ehresman, DJ; Nelson, BD; Qazi, MR; Xia, Z1
Aoyama, T; Gonzalez, FJ; Hayashi, Y; Ito, Y; Kono, Y; Li, Y; Naito, H; Nakajima, T; Nakamura, T; Ramdhan, DH; Yanagiba, Y1
Hatch, EE; Nelson, JW; Webster, TF1
Butenhoff, JL; Chang, SC; Elcombe, BM; Elcombe, CR; Farrar, DG; Foster, JR; Jung, R; Kennedy, GL1
Abedel-Latif, M; El-Nasser, MA; Sato, I; Tsuda, S; Tsukuba, C; Yahia, D; Yoshida, M1
Cho, NK; Kim, DH; Kim, JH; Lee, CH; Lee, CK; Lee, JT; Son, BC; Suh, CH1
Fenton, SE; Helfant, L; Macon, MB; Stanko, JP; Strynar, MJ; Tatum-Gibbs, K; Villanueva, LR; White, SS; Zehr, RD1
Andersen, ME; Butenhoff, JL; Campbell, JL; Clewell, HJ; Loccisano, AE2
Butenhoff, JL; Chang, SC; Kennedy, GL; Olsen, GW1
Abedi-Valugerdi, M; DePierre, JW; Nelson, BD; Qazi, MR1
Calafat, AM; Christensen, KY; Holmes, A; Maisonet, M; Marcus, M; McGeehin, MA; Terrell, ML1
Butenhoff, J; Costa, G; Elcombe, C; Farrar, D; Hansen, K; Iwai, H; Jung, R; Kennedy, G; Lieder, P; Olsen, G; Thomford, P1
Butenhoff, JL; Frame, SR; Kennedy, GL; O'Connor, JC; York, RG1
Butenhoff, JL; Gaylor, DW; Mandel, JH; Moore, JA; Olsen, GW; Rodricks, J; Zobel, LR1
Butenhoff, JL; Gorman, GS; Hansen, KJ; Hinderliter, PM; Jung, R; Kennedy, GL; Lieder, PH; Noker, PE; Thomford, PJ1
Butenhoff, JL; Kennedy, GL; Palazzolo, MJ; Perkins, RG1
Butenhoff, JL; Gannon, SA; Hinderliter, PM; Kennedy, GL; Mylchreest, E1
Iwai, H; Yamashita, K1
Butenhoff, JL; Han, X; Hinderliter, PM; Kennedy, GL1
Kawashima, Y; Kudo, N; Mitsumoto, A; Suzuki-Nakajima, E1
Henderson, WM; Smith, MA1
Abbott, BD; Bryant, XA; Calafat, AM; Das, KP; Fenton, SE; Kuklenyik, Z; Lau, CS; Schmid, JE; Thibodeaux, J; White, SS; Wolf, CJ1
Calafat, AM; Fenton, SE; Helfant, L; Kuklenyik, Z; Lindstrom, AB; Strynar, MJ; Thibodeaux, JR; Villanueva, L; White, SS; Wood, C; Zehr, RD1
Anderson, SE; Fairley, KJ; Kearns, S; Meade, B; Purdy, R1
Iannucci, A; Scialli, AR; Turim, J1
Andersen, ME; Olson, CT1
Griffith, FD; Long, JE1
Kawashima, Y; Kobayashi, H; Kozuka, H; Miura, H1
Kawashima, Y; Kozuka, H; Sato, M; Suzuki, S; Suzuki, Y1
Chinje, E; Diaz, MJ; George, M; Gibson, G; Jarnot, B; Kentish, P1
Andersson, K; De Pierre, JW; Olsson, U; Sundberg, C1
Goecke-Flora, CM; Reo, NV1
Kawashima, Y; Kudo, N1
DePierre, JW; Eriksson, AM; Nelson, BD; Xie, Y; Yang, Q1
Andersson, K; DePierre, JW; Lundgren, B; Permadi, H1
Cook, JC; Frame, SR; Hurtt, ME; Murray, SM1
Chromey, NC; Kennedy, GL; Kinney, LA1
Gorgas, K; Hartl, FU; Heinemann, P; Just, WW; Salzer, M; Schimassek, H1
Gillies, PJ; Lee, KP; Pastoor, TP; Perri, MA1
Kennedy, GL2
Barnes, JR; Brittelli, MR; Chen, HC; Hall, GT; Kennedy, GL1

Other Studies

64 other study(ies) available for perfluorooctanoic acid and Body Weight

ArticleYear
Exposure to low-dose perfluorooctanoic acid promotes hepatic steatosis and disrupts the hepatic transcriptome in mice.
    Molecular metabolism, 2022, Volume: 66

    Topics: Animals; Body Weight; Fluorocarbons; Glucose; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; PPAR alpha; Transcriptome; Triglycerides

2022
Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPARα mice fed an American diet.
    Toxicology and applied pharmacology, 2020, 10-15, Volume: 405

    Topics: Animals; Body Weight; Caprylates; Cholesterol; Constitutive Androstane Receptor; Diet, Western; Female; Fluorocarbons; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Size; PPAR alpha; Receptors, Cytoplasmic and Nuclear; Sex Characteristics; Transcriptome; Water Pollutants, Chemical

2020
Toxicology and carcinogenesis studies of perfluorooctanoic acid administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised).
    National Toxicology Program technical report series, 2020, Issue:598

    Topics: Adenocarcinoma; Adenoma; Animals; Body Weight; Caprylates; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Dose-Response Relationship, Drug; Drug Administration Routes; Female; Fluorocarbons; Liver Neoplasms; Male; Pancreatic Neoplasms; Rats; Rats, Sprague-Dawley; Survival Rate

2020
Perfluorooctanoic acid induces liver and serum dyslipidemia in humanized PPARα mice fed an American diet.
    Toxicology and applied pharmacology, 2021, 09-01, Volume: 426

    Topics: Animals; Body Weight; Caprylates; Diet, Western; Dyslipidemias; Female; Fluorocarbons; Gene Expression; Genotype; Lipidomics; Liver; Male; Mice, Transgenic; Organ Size; PPAR alpha; Triglycerides; United States

2021
Longitudinal trends of per- and polyfluoroalkyl substances in children's serum.
    Environment international, 2018, Volume: 121, Issue:Pt 1

    Topics: Alkanesulfonic Acids; Body Weight; Breast Feeding; Caprylates; Child; Child, Preschool; Dust; Environmental Pollutants; Female; Fluorocarbons; Humans; Infant; Male; Sulfonic Acids

2018
Neonatal and juvenile exposure to perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS): Advance puberty onset and kisspeptin system disturbance in female rats.
    Ecotoxicology and environmental safety, 2019, Jan-15, Volume: 167

    Topics: Alkanesulfonic Acids; Animals; Body Weight; Caprylates; Down-Regulation; Estradiol; Estrogen Receptor alpha; Estrous Cycle; Female; Fluorocarbons; Hypothalamus; Kisspeptins; Luteinizing Hormone; Ovarian Follicle; Rats; Receptors, Kisspeptin-1; RNA, Messenger; Sexual Maturation

2019
Maternal exposure to perfluorooctanoic acid (PFOA) causes liver toxicity through PPAR-α pathway and lowered histone acetylation in female offspring mice.
    Environmental science and pollution research international, 2019, Volume: 26, Issue:18

    Topics: Acetylation; Animals; Body Weight; Caprylates; Female; Fluorocarbons; Histones; Lipid Metabolism; Liver; Maternal Exposure; Mice; Necrosis; Oxidative Stress; PPAR alpha; Pregnancy; Prenatal Exposure Delayed Effects; Random Allocation

2019
High fat diet feeding exaggerates perfluorooctanoic acid-induced liver injury in mice via modulating multiple metabolic pathways.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: Adipose Tissue, White; Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Caprylates; Diet, High-Fat; Fatty Acids; Fatty Liver; Fluorocarbons; Gene Expression Profiling; Gene Expression Regulation; Hepatocytes; Inflammation; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Necrosis; Organ Size; Triglycerides

2013
In utero exposure to perfluorooctanoate (PFOA) or perfluorooctane sulfonate (PFOS) did not increase body weight or intestinal tumorigenesis in multiple intestinal neoplasia (Min/+) mice.
    Environmental research, 2014, Volume: 132

    Topics: Alkanesulfonic Acids; Animals; Blood Glucose; Body Weight; Caprylates; Carcinogenesis; Eating; Female; Fluorocarbons; Intestinal Neoplasms; Liver; Male; Mice; Mice, Inbred C57BL; Obesity; Organ Size; Pregnancy; Reproduction; Spleen

2014
Hepatic Mitochondrial Alteration in CD-1 Mice Associated with Prenatal Exposures to Low Doses of Perfluorooctanoic Acid (PFOA).
    Toxicologic pathology, 2015, Volume: 43, Issue:4

    Topics: Animals; Body Weight; Caprylates; Dose-Response Relationship, Drug; Female; Fluorocarbons; Hepatocytes; Liver; Mice; Mitochondria, Liver; PPAR alpha; Pregnancy; Prenatal Exposure Delayed Effects

2015
Programming of metabolic effects in C57BL/6JxFVB mice by in utero and lactational exposure to perfluorooctanoic acid.
    Archives of toxicology, 2016, Volume: 90, Issue:3

    Topics: Animals; Body Weight; Caprylates; Cholesterol; Diet, High-Fat; Dose-Response Relationship, Drug; Female; Fluorocarbons; Lactation; Male; Maternal Exposure; Mice, Inbred C57BL; Mice, Inbred Strains; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects

2016
Effects of Perfluorooctanoic Acid on Metabolic Profiles in Brain and Liver of Mouse Revealed by a High-throughput Targeted Metabolomics Approach.
    Scientific reports, 2016, Apr-01, Volume: 6

    Topics: Animals; Body Weight; Brain Chemistry; Caprylates; Environmental Pollutants; Fluorocarbons; High-Throughput Screening Assays; Lipid Metabolism; Liver; Male; Metabolomics; Mice; Mice, Inbred BALB C; Neurotransmitter Agents; Organ Specificity

2016
Longitudinal Associations of Exposure to Perfluoroalkylated Substances in Childhood and Adolescence and Indicators of Adiposity and Glucose Metabolism 6 and 12 Years Later: The European Youth Heart Study.
    Diabetes care, 2016, Volume: 39, Issue:10

    Topics: Adiposity; Adolescent; Alkanesulfonic Acids; Blood Glucose; Body Mass Index; Body Weight; Caprylates; Child; Cross-Sectional Studies; Environmental Exposure; Europe; Female; Fluorocarbons; Humans; Insulin; Insulin Resistance; Longitudinal Studies; Male; Pediatric Obesity; Prospective Studies; Skinfold Thickness; Socioeconomic Factors; Surveys and Questionnaires; Triglycerides; Waist Circumference; Young Adult

2016
Gestational exposure to perfluorooctanoic acid (PFOA): Alterations in motor related behaviors.
    Neurotoxicology, 2017, Volume: 58

    Topics: Analysis of Variance; Animals; Body Weight; Caprylates; Cohort Studies; Dose-Response Relationship, Drug; Environmental Pollutants; Female; Fluorocarbons; Gestational Age; Mice; Motor Disorders; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Reflex, Startle; Running

2017
Evaluation of the immune system in rats and mice administered linear ammonium perfluorooctanoate.
    Toxicological sciences : an official journal of the Society of Toxicology, 2008, Volume: 105, Issue:1

    Topics: Animals; Blood Cell Count; Body Weight; Caprylates; Corticosterone; Dose-Response Relationship, Drug; Fluorocarbons; Immune System; Immunoglobulin M; Lipids; Liver; Male; Mice; Mice, Inbred ICR; No-Observed-Adverse-Effect Level; Organ Size; PPAR alpha; Rats; Rats, Sprague-Dawley; Spleen; Thymus Gland

2008
Studies on the toxicological effects of PFOA and PFOS on rats using histological observation and chemical analysis.
    Archives of environmental contamination and toxicology, 2009, Volume: 56, Issue:2

    Topics: Alkanesulfonic Acids; Animals; Behavior, Animal; Body Weight; Caprylates; Dose-Response Relationship, Drug; Environmental Pollutants; Fluorocarbons; Kidney; Liver; Lung; Male; Organ Specificity; Rats; Rats, Sprague-Dawley; Tissue Distribution; Toxicity Tests, Chronic

2009
Neonatal exposure to PFOS and PFOA in mice results in changes in proteins which are important for neuronal growth and synaptogenesis in the developing brain.
    Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 108, Issue:2

    Topics: Alkanesulfonic Acids; Animals; Animals, Newborn; Body Weight; Brain; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Caprylates; Female; Fluorocarbons; GAP-43 Protein; Male; Mice; Nerve Tissue Proteins; Neurons; Pregnancy; Synapses; Synaptophysin; tau Proteins

2009
Suppression of humoral immunity by perfluorooctanoic acid is independent of elevated serum corticosterone concentration in mice.
    Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 109, Issue:1

    Topics: Adrenalectomy; Analysis of Variance; Animals; Antibody Formation; Blood Chemical Analysis; Body Weight; Caprylates; Corticosterone; Female; Fluorocarbons; Immune Tolerance; Immunoglobulin M; Immunosuppressive Agents; Mice; Mice, Inbred C57BL

2009
Analysis of PFOA in dosed CD-1 mice. Part 2. Disposition of PFOA in tissues and fluids from pregnant and lactating mice and their pups.
    Reproductive toxicology (Elmsford, N.Y.), 2009, Volume: 27, Issue:3-4

    Topics: Amniotic Fluid; Animals; Animals, Newborn; Blood Chemical Analysis; Body Weight; Caprylates; Dose-Response Relationship, Drug; Environmental Pollutants; Female; Fluorocarbons; Lactation; Maternal Exposure; Mice; Mice, Inbred Strains; Milk; Pregnancy; Prenatal Exposure Delayed Effects; Urinalysis

2009
Pharmacokinetic modeling of perfluorooctanoic acid during gestation and lactation in the mouse.
    Reproductive toxicology (Elmsford, N.Y.), 2009, Volume: 27, Issue:3-4

    Topics: Animals; Area Under Curve; Body Weight; Caprylates; Computer Simulation; Dose-Response Relationship, Drug; Environmental Pollutants; Female; Fluorocarbons; Gestational Age; Half-Life; Lactation; Metabolic Clearance Rate; Mice; Mice, Inbred Strains; Models, Statistical; Predictive Value of Tests; Pregnancy

2009
Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: Low doses induce elevated serum leptin and insulin, and overweight in mid-life.
    Molecular and cellular endocrinology, 2009, May-25, Volume: 304, Issue:1-2

    Topics: Animals; Body Weight; Caprylates; Female; Fluorocarbons; Humans; Insulin; Leptin; Maternal Exposure; Mice; Organ Size; Ovariectomy; Overweight; Phenotype; Pregnancy; Prenatal Exposure Delayed Effects; Random Allocation

2009
The atrophy and changes in the cellular compositions of the thymus and spleen observed in mice subjected to short-term exposure to perfluorooctanesulfonate are high-dose phenomena mediated in part by peroxisome proliferator-activated receptor-alpha (PPARa
    Toxicology, 2009, Jun-16, Volume: 260, Issue:1-3

    Topics: Alkanesulfonic Acids; Animals; Atrophy; B-Lymphocytes; Body Weight; Caprylates; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Immunologic; Flow Cytometry; Fluorocarbons; Immunophenotyping; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Organ Size; PPAR alpha; Spleen; T-Lymphocytes; Thymus Gland

2009
Microgram-order ammonium perfluorooctanoate may activate mouse peroxisome proliferator-activated receptor alpha, but not human PPARalpha.
    Toxicology, 2009, Nov-09, Volume: 265, Issue:1-2

    Topics: Alanine Transaminase; Animals; Biotransformation; Blotting, Western; Body Weight; Caprylates; Cell Nucleus; CHO Cells; Cricetinae; Cricetulus; Female; Fluorocarbons; Gene Expression; Humans; Lipid Metabolism; Lipids; Male; Mice; Mice, Knockout; Organ Size; PPAR alpha; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Species Specificity

2009
Exposure to polyfluoroalkyl chemicals and cholesterol, body weight, and insulin resistance in the general U.S. population.
    Environmental health perspectives, 2010, Volume: 118, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alkanesulfonic Acids; Body Weight; Caprylates; Child; Cholesterol; Cross-Sectional Studies; Environmental Exposure; Female; Fluorocarbons; Humans; Insulin Resistance; Linear Models; Lipid Metabolism; Male; Middle Aged; Young Adult

2010
Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARα and CAR/PXR.
    Archives of toxicology, 2010, Volume: 84, Issue:10

    Topics: Animals; Apoptosis; Body Weight; Caprylates; Cell Proliferation; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; DNA; Environmental Pollutants; Fluorocarbons; Hepatocytes; Hepatomegaly; Hypertrophy; Liver; Male; Organ Size; Peroxisomes; PPAR alpha; Pregnane X Receptor; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid

2010
Effects of perfluorooctanoic acid (PFOA) exposure to pregnant mice on reproduction.
    The Journal of toxicological sciences, 2010, Volume: 35, Issue:4

    Topics: Animals; Body Weight; Caprylates; Female; Fetus; Fluorocarbons; Gravidity; Liver; Maternal Exposure; Mice; Mice, Inbred ICR; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects; Reproduction

2010
Perfluorooctanoic acid-induced inhibition of placental prolactin-family hormone and fetal growth retardation in mice.
    Molecular and cellular endocrinology, 2011, Apr-30, Volume: 337, Issue:1-2

    Topics: Animals; Body Weight; Caprylates; Cell Count; Cytokines; Female; Fetal Death; Fetal Growth Retardation; Fetal Weight; Fluorocarbons; Mice; Placenta; Placental Hormones; Placental Lactogen; Pregnancy; Pregnancy Proteins; Transcription Factor Pit-1; Transcription, Genetic; Trophoblasts

2011
Prenatal perfluorooctanoic acid exposure in CD-1 mice: low-dose developmental effects and internal dosimetry.
    Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 122, Issue:1

    Topics: Animals; Animals, Newborn; Body Weight; Caprylates; Dose-Response Relationship, Drug; Female; Fluorocarbons; Gestational Age; Liver; Male; Mammary Glands, Animal; Maternal Exposure; Mice; Mice, Inbred Strains; No-Observed-Adverse-Effect Level; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects; Sensitivity and Specificity

2011
Comparison and evaluation of pharmacokinetics of PFOA and PFOS in the adult rat using a physiologically based pharmacokinetic model.
    Reproductive toxicology (Elmsford, N.Y.), 2012, Volume: 33, Issue:4

    Topics: Alkanesulfonic Acids; Animals; Body Weight; Caprylates; Cardiac Output; Computer Simulation; Female; Fluorocarbons; Intestinal Mucosa; Intestines; Kidney; Liver; Male; Metabolic Clearance Rate; Models, Biological; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sex Factors; Time Factors; Tissue Distribution

2012
Evaluation of placental and lactational pharmacokinetics of PFOA and PFOS in the pregnant, lactating, fetal and neonatal rat using a physiologically based pharmacokinetic model.
    Reproductive toxicology (Elmsford, N.Y.), 2012, Volume: 33, Issue:4

    Topics: Aging; Alkanesulfonic Acids; Animals; Animals, Newborn; Body Weight; Caprylates; Computer Simulation; Dose-Response Relationship, Drug; Female; Fetal Blood; Fluorocarbons; Gestational Age; Lactation; Liver; Maternal Exposure; Maternal-Fetal Exchange; Milk; Models, Biological; Placenta; Pregnancy; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Tissue Distribution

2012
Chronic dietary toxicity and carcinogenicity study with ammonium perfluorooctanoate in Sprague-Dawley rats.
    Toxicology, 2012, Aug-16, Volume: 298, Issue:1-3

    Topics: Animals; Body Weight; Caprylates; Carcinogenicity Tests; Diet; Female; Fluorocarbons; Liver; Male; Organ Size; Rats; Rats, Sprague-Dawley; Survival Rate

2012
High-dose dietary exposure of mice to perfluorooctanoate or perfluorooctane sulfonate exerts toxic effects on myeloid and B-lymphoid cells in the bone marrow and these effects are partially dependent on reduced food consumption.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2012, Volume: 50, Issue:9

    Topics: Alkanesulfonic Acids; Animals; B-Lymphocytes; Body Weight; Bone Marrow Cells; Caprylates; Dose-Response Relationship, Drug; Feeding Behavior; Flow Cytometry; Fluorocarbons; Male; Mice; Mice, Inbred C57BL

2012
Maternal concentrations of polyfluoroalkyl compounds during pregnancy and fetal and postnatal growth in British girls.
    Environmental health perspectives, 2012, Volume: 120, Issue:10

    Topics: Adolescent; Age Factors; Alkanesulfonic Acids; Birth Weight; Body Weight; Caprylates; Child; Cohort Studies; England; Environmental Monitoring; Environmental Pollutants; Female; Fetal Development; Fluorocarbons; Gestational Age; Humans; Infant; Infant, Newborn; Longitudinal Studies; Maternal Exposure; Multivariate Analysis; Pregnancy; Prenatal Exposure Delayed Effects; Regression Analysis; Sulfonic Acids

2012
Toxicity of ammonium perfluorooctanoate in male cynomolgus monkeys after oral dosing for 6 months.
    Toxicological sciences : an official journal of the Society of Toxicology, 2002, Volume: 69, Issue:1

    Topics: Acyl Coenzyme A; Animals; Bilirubin; Body Weight; Caprylates; Cell Division; Cholecystokinin; DNA; DNA Replication; Estradiol; Fluorocarbons; Hormones; Liver; Macaca fascicularis; Male; Organ Size; Pancreas; Peroxisome Proliferators; Rats; Subcellular Fractions; Testis

2002
The reproductive toxicology of ammonium perfluorooctanoate (APFO) in the rat.
    Toxicology, 2004, Mar-01, Volume: 196, Issue:1-2

    Topics: Animals; Body Weight; Caprylates; Dose-Response Relationship, Drug; Eating; Female; Fluorocarbons; Growth; Litter Size; Male; Organ Size; Pregnancy; Rats; Rats, Sprague-Dawley; Reproduction; Sexual Maturation; Surface-Active Agents; Survival Analysis

2004
Characterization of risk for general population exposure to perfluorooctanoate.
    Regulatory toxicology and pharmacology : RTP, 2004, Volume: 39, Issue:3

    Topics: Adult; Aged; Animals; Animals, Newborn; Area Under Curve; Body Weight; Brain; Caprylates; Child; Dose-Response Relationship, Drug; Environmental Exposure; Female; Fluorocarbons; Half-Life; Haplorhini; Humans; Leydig Cell Tumor; Liver; Male; Models, Biological; Organ Size; Pregnancy; Rats; Risk Assessment; Testicular Neoplasms; Toxicity Tests

2004
Pharmacokinetics of perfluorooctanoate in cynomolgus monkeys.
    Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 82, Issue:2

    Topics: Animals; Body Weight; Caprylates; Data Interpretation, Statistical; Feces; Female; Fluorocarbons; Half-Life; Injections, Intravenous; Liver; Macaca fascicularis; Male; Quality Control; Reference Standards

2004
13-week dietary toxicity study of ammonium perfluorooctanoate (APFO) in male rats.
    Drug and chemical toxicology, 2004, Volume: 27, Issue:4

    Topics: Animals; Body Weight; Caprylates; Diet; Dose-Response Relationship, Drug; Estradiol; Fluorocarbons; Liver; Male; Organ Size; Oxidoreductases; Rats; Testosterone

2004
Perfluorooctanoate: Placental and lactational transport pharmacokinetics in rats.
    Toxicology, 2005, Jul-01, Volume: 211, Issue:1-2

    Topics: Animals; Biotransformation; Body Weight; Caprylates; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Fetus; Fluorocarbons; Lactation; Litter Size; Mass Spectrometry; Maternal-Fetal Exchange; Milk; Placenta; Pregnancy; Rats

2005
A fourteen-day repeated dose oral toxicity study of APFO in rats.
    Drug and chemical toxicology, 2006, Volume: 29, Issue:3

    Topics: Animals; Antibodies, Monoclonal; Blood Cell Count; Blood Chemical Analysis; Blood Glucose; Body Weight; Caprylates; Cholesterol; Fluorocarbons; Immunity, Cellular; Lipid Metabolism; Liver; Lymphocyte Count; Lymphocyte Subsets; Male; Organ Size; Peroxisomes; Phospholipids; Rats; Triglycerides

2006
Age effect on perfluorooctanoate (PFOA) plasma concentration in post-weaning rats following oral gavage with ammonium perfluorooctanoate (APFO).
    Toxicology, 2006, Aug-15, Volume: 225, Issue:2-3

    Topics: Administration, Oral; Age Factors; Animals; Body Weight; Caprylates; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Fluorocarbons; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Sex Factors; Surface-Active Agents; Weaning

2006
Responses of the liver to perfluorinated fatty acids with different carbon chain length in male and female mice:in relation to induction of hepatomegaly, peroxisomal beta-oxidation and microsomal 1-acylglycerophosphocholine acyltransferase.
    Biological & pharmaceutical bulletin, 2006, Volume: 29, Issue:9

    Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Animals; Body Weight; Caproates; Caprylates; Female; Fluorocarbons; Hepatomegaly; Liver; Male; Mice; Microsomes, Liver; Organ Size; Oxidation-Reduction; Peroxisomes; Sex Characteristics; Structure-Activity Relationship

2006
Perfluorooctanoic acid and perfluorononanoic acid in fetal and neonatal mice following in utero exposure to 8-2 fluorotelomer alcohol.
    Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 95, Issue:2

    Topics: Animals; Animals, Newborn; Body Burden; Body Weight; Caprylates; Environmental Pollutants; Fatty Alcohols; Female; Fluorocarbons; Gestational Age; Liver; Mice; Mice, Inbred Strains; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects; Tissue Distribution

2007
Developmental toxicity of perfluorooctanoic acid in the CD-1 mouse after cross-foster and restricted gestational exposures.
    Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 95, Issue:2

    Topics: Animals; Birth Weight; Body Weight; Caprylates; Environmental Pollutants; Female; Fluorocarbons; Gestational Age; Lactation; Litter Size; Male; Mice; Mice, Inbred Strains; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects

2007
Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring.
    Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 96, Issue:1

    Topics: Administration, Oral; Animals; Animals, Newborn; Body Weight; Caprylates; Cell Differentiation; Dose-Response Relationship, Drug; Environmental Pollutants; Female; Fluorocarbons; Gene Expression Regulation; Gestational Age; Liver; Mammary Glands, Animal; Maternal Exposure; Mice; Milk Proteins; Pregnancy; Prenatal Exposure Delayed Effects; RNA, Messenger; Time Factors

2007
Exposure to the immunosuppressant, perfluorooctanoic acid, enhances the murine IgE and airway hyperreactivity response to ovalbumin.
    Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 97, Issue:2

    Topics: Administration, Topical; Animals; Antigens; Asthma; Body Weight; Bronchial Hyperreactivity; Caprylates; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Fluorocarbons; Hypersensitivity; Immunoglobulin E; Immunosuppressive Agents; Lung; Mice; Mice, Inbred BALB C; Organ Size; Ovalbumin; Phenotype; Respiratory Hypersensitivity

2007
Combining perfluoroalkane acid exposure levels for risk assessment.
    Regulatory toxicology and pharmacology : RTP, 2007, Volume: 49, Issue:3

    Topics: Acids; Alkanes; Alkanesulfonic Acids; Animals; Animals, Newborn; Body Weight; Caprylates; Data Interpretation, Statistical; Decanoic Acids; Dose-Response Relationship, Drug; Embryonic Development; Environmental Exposure; Female; Fetal Development; Fluorocarbons; Male; Mice; Penis; Rats; Risk Assessment; Toxicity Tests

2007
The acute toxicity of perfluorooctanoic and perfluorodecanoic acids in male rats and effects on tissue fatty acids.
    Toxicology and applied pharmacology, 1983, Sep-30, Volume: 70, Issue:3

    Topics: Animals; Blood; Body Weight; Caprylates; Decanoic Acids; Fatty Acids; Feeding Behavior; Fluorocarbons; Liver; Male; Organ Size; Rats; Rats, Inbred F344; Testis; Time Factors

1983
Animal toxicity studies with ammonium perfluorooctanoate.
    American Industrial Hygiene Association journal, 1980, Volume: 41, Issue:8

    Topics: Animals; Body Weight; Caprylates; Dose-Response Relationship, Drug; Female; Fluorocarbons; Haplorhini; Lethal Dose 50; Liver; Macaca mulatta; Male; Mice; Mutagens; Organ Size; Rabbits; Rats; Time Factors

1980
Characterization of hepatic responses of rat to administration of perfluorooctanoic and perfluorodecanoic acids at low levels.
    Toxicology, 1995, May-23, Volume: 99, Issue:3

    Topics: Analysis of Variance; Animals; Body Weight; Caprylates; Decanoic Acids; Diet; Fluorocarbons; Lipid Metabolism; Liver; Male; Organ Size; Rats; Rats, Wistar

1995
Effects of prolonged administration of perfluorooctanoic acid on hepatic activities of enzymes which detoxify peroxide and xenobiotic in the rat.
    Toxicology, 1994, Nov-11, Volume: 93, Issue:2-3

    Topics: Animals; Body Weight; Caprylates; Female; Fluorocarbons; Glutathione Peroxidase; Glutathione Transferase; Hydrogen Peroxide; Inactivation, Metabolic; Lipid Peroxidation; Liver; Male; Microbodies; Organ Size; Rats; Rats, Wistar; Sex Factors; Xenobiotics

1994
Induction of cytochrome P4504A by the peroxisome proliferator perfluoro-n-octanoic acid.
    Toxicology, 1994, Jan-26, Volume: 86, Issue:1-2

    Topics: Animals; Blotting, Western; Body Weight; Caprylates; Cytochrome P-450 Enzyme System; Enzyme Induction; Fluorocarbons; Isoenzymes; Kidney; Liver; Male; Microbodies; Microsomes, Liver; Mixed Function Oxygenases; Rats; Rats, Wistar

1994
Further studies on the involvement of selenium in peroxisome proliferation in rat liver. Comparison of effects with clofibric acid and perfluorooctanoic acid and the pharmacokinetics of [14C]clofibrate.
    Biochemical pharmacology, 1993, Nov-17, Volume: 46, Issue:10

    Topics: Animals; Body Weight; Caprylates; Catalase; Clofibric Acid; Eating; Fatty Acids; Fluorocarbons; Liver; Microbodies; Mitochondria, Liver; Palmitoyl Coenzyme A; Rats; Selenium; Tissue Distribution

1993
Influence of carbon chain length on the hepatic effects of perfluorinated fatty acids. A 19F- and 31P-NMR investigation.
    Chemical research in toxicology, 1996, Volume: 9, Issue:4

    Topics: Acyl-CoA Oxidase; Adenosine Triphosphate; Animal Feed; Animals; Bile; Body Weight; Caprylates; Cell Survival; Decanoic Acids; Eating; Fatty Acids; Fluorine; Fluorocarbons; Heptanoic Acids; Injections, Intraperitoneal; Liver; Magnetic Resonance Spectroscopy; Male; Microbodies; Oxidoreductases; Phosphorus Isotopes; Rats; Rats, Inbred F344; Time Factors

1996
Fish oil-feeding prevents perfluorooctanoic acid-induced fatty liver in mice.
    Toxicology and applied pharmacology, 1997, Volume: 145, Issue:2

    Topics: alpha-Linolenic Acid; Animals; Body Weight; Caprylates; Fatty Acids; Fatty Liver; Fish Oils; Fluorocarbons; Lipid Peroxidation; Liver; Male; Mice; Microbodies; Organ Size; Phospholipids; Plant Oils; Soybean Oil; Triglycerides

1997
Further evidence for the involvement of inhibition of cell proliferation and development in thymic and splenic atrophy induced by the peroxisome proliferator perfluoroctanoic acid in mice.
    Biochemical pharmacology, 2001, Oct-15, Volume: 62, Issue:8

    Topics: Animals; Atrophy; Body Weight; Caprylates; Cell Cycle; Cell Division; Dose-Response Relationship, Drug; Fluorocarbons; Hypertrophy; Liver; Male; Mice; Mice, Inbred C57BL; Models, Animal; Organ Size; Peroxisome Proliferators; Peroxisomes; Phenotype; Spleen; Substance Withdrawal Syndrome; Thymus Gland; Time Factors

2001
Effects of perfluoro fatty acids on xenobiotic-metabolizing enzymes, enzymes which detoxify reactive forms of oxygen and lipid peroxidation in mouse liver.
    Biochemical pharmacology, 1992, Sep-25, Volume: 44, Issue:6

    Topics: Animals; Body Weight; Caprylates; Cytochrome P-450 Enzyme System; Cytochromes b5; Decanoic Acids; Dose-Response Relationship, Drug; Enzyme Activation; Epoxide Hydrolases; Fluorocarbons; Liver; Male; Mice; Mice, Inbred C57BL; NAD(P)H Dehydrogenase (Quinone); NADPH-Ferrihemoprotein Reductase; Organ Size; Subcellular Fractions; Time Factors

1992
Induction of Leydig cell adenomas by ammonium perfluorooctanoate: a possible endocrine-related mechanism.
    Toxicology and applied pharmacology, 1992, Volume: 113, Issue:2

    Topics: Adenoma; Administration, Oral; Animals; Body Weight; Caprylates; Chorionic Gonadotropin; Dose-Response Relationship, Drug; Estradiol; Fluorocarbons; Leydig Cell Tumor; Liver; Male; Organ Size; Radioimmunoassay; Rats; Testicular Neoplasms; Testosterone

1992
Acute inhalation toxicity of ammonium perfluorononanoate.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1989, Volume: 27, Issue:7

    Topics: Administration, Inhalation; Air Pollutants; Animals; Body Weight; Caprylates; Fluorocarbons; Liver; Male; Organ Size; Rats

1989
Biochemical effects and zonal heterogeneity of peroxisome proliferation induced by perfluorocarboxylic acids in rat liver.
    Hepatology (Baltimore, Md.), 1989, Volume: 9, Issue:4

    Topics: Animals; Body Weight; Caprylates; Coenzyme A; Fluoroacetates; Fluorocarbons; Lipid Metabolism; Liver; Male; Membrane Proteins; Microbodies; Microscopy, Electron; Molecular Weight; Organ Size; Rats; Rats, Inbred Strains; Trifluoroacetic Acid

1989
Biochemical and morphological studies of ammonium perfluorooctanoate-induced hepatomegaly and peroxisome proliferation.
    Experimental and molecular pathology, 1987, Volume: 47, Issue:1

    Topics: Animals; Body Weight; Caprylates; DNA; Endoplasmic Reticulum; Fluorocarbons; Hepatomegaly; Lipids; Liver; Male; Microbodies; Microscopy, Electron; Microsomes; Mitochondria, Liver; Organ Size; Rats

1987
Increase in mouse liver weight following feeding of ammonium perfluorooctanoate and related fluorochemicals.
    Toxicology letters, 1987, Volume: 39, Issue:2-3

    Topics: Animals; Body Weight; Caprylates; Dose-Response Relationship, Drug; Female; Fluorocarbons; Liver; Male; Mice; Organ Size

1987
Inhalation toxicity of ammonium perfluorooctanoate.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1986, Volume: 24, Issue:12

    Topics: Administration, Inhalation; Animals; Body Weight; Caprylates; Cornea; Fluorides; Fluorocarbons; Liver; Necrosis; Organ Size; Pulmonary Edema; Rats

1986
Dermal toxicity of ammonium perfluorooctanoate.
    Toxicology and applied pharmacology, 1985, Volume: 81, Issue:2

    Topics: Administration, Topical; Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Caprylates; Erythema; Female; Fluorocarbons; Lethal Dose 50; Male; Organ Size; Rabbits; Rats; Sex Factors; Species Specificity

1985