perazine has been researched along with Schizophrenia in 44 studies
Perazine: A phenothiazine antipsychotic with actions and uses similar to those of CHLORPROMAZINE. Extrapyramidal symptoms may be more common than other side effects.
perazine : A phenothiazine derivative in which 10H-phenothiazinecarries a 3-(4-methylpiperazin-1-yl)propyl substituent at the N-10 position.
Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Perazine is an old phenothiazine derivative used for the treatment of people with schizophrenia and is reputed to have a low level of extrapyramidal adverse effects." | 8.90 | Perazine for schizophrenia. ( Hartung, B; Helfer, B; Leucht, S, 2014) |
| "Perazine is an old phenothiazine derivative used for the treatment of people with schizophrenia and is reputed to have a low level of extrapyramidal adverse effects." | 8.83 | Perazine for schizophrenia. ( Hartung, B; Leucht, S, 2006) |
| "Perazine is an old phenothiazine derivative used for the treatment of people with schizophrenia which has a reputed low level of extrapyramidal side-effects." | 8.81 | Perazine for schizophrenia. ( Hartung, B; Leucht, S, 2002) |
| " Perazine in combination with carbamazepine has shown satisfying results in several single-schizophrenia patients, leading to the hypothesis of being equal or even superior to atypical antipsychotic monotherapy." | 7.74 | Perazine and carbamazepine in comparison to olanzapine in schizophrenia. ( Emrich, HM; Godecke-Koch, T; Hoffmann, J; Jahn, K; Ohlmeier, MD; Schneider, U; Seifert, J; Wilhelm-Gossling, C, 2007) |
| "40 inpatients suffering from a schizophrenia (ICD-9) were treated with either zotepine or perazin." | 5.07 | [Effectiveness and tolerance of zotepine in a double-blind comparison with perazine in schizophrenic patients]. ( Ackenheil, M; Dieterle, DM; Müller-Spahn, F, 1991) |
| "Perazine is an old phenothiazine derivative used for the treatment of people with schizophrenia and is reputed to have a low level of extrapyramidal adverse effects." | 4.90 | Perazine for schizophrenia. ( Hartung, B; Helfer, B; Leucht, S, 2014) |
| "Perazine is an old phenothiazine derivative used for the treatment of people with schizophrenia and is reputed to have a low level of extrapyramidal adverse effects." | 4.83 | Perazine for schizophrenia. ( Hartung, B; Leucht, S, 2006) |
| "Perazine is an old phenothiazine derivative used for the treatment of people with schizophrenia which has a reputed low level of extrapyramidal side-effects." | 4.81 | Perazine for schizophrenia. ( Hartung, B; Leucht, S, 2002) |
| " Perazine in combination with carbamazepine has shown satisfying results in several single-schizophrenia patients, leading to the hypothesis of being equal or even superior to atypical antipsychotic monotherapy." | 3.74 | Perazine and carbamazepine in comparison to olanzapine in schizophrenia. ( Emrich, HM; Godecke-Koch, T; Hoffmann, J; Jahn, K; Ohlmeier, MD; Schneider, U; Seifert, J; Wilhelm-Gossling, C, 2007) |
| " The pharmacokinetic parameters investigated seem to have a limited influence on the clinical outcome." | 2.65 | Prediction and evaluation criteria in perazine therapy of acute schizophrenics. Pharmacokinetic data. ( Breyer-Pfaff, U; Brinkschulte, M; Rein, W; Schied, HW; Straube, E, 1983) |
| " A close connection existed between perazine dosage and perazine serum level." | 2.64 | [Relationship between perazine serum concentration and clinical results in long-term treated schizophrenic outpatients (author's transl)]. ( Chaskel, H; Müller-Oerlinghausen, B; Pietzcker, A; Poppenberg, A; Schley, J; Urban, R, 1978) |
| " Numerous patients had already modified their neuroleptic dosage on their own initiative, in most cases discontinuing their medication but in some cases increasing or reducing the dose." | 1.29 | [Experiences of schizophrenic patients in ambulatory care with oral neuroleptics--baseline for psychoeducational interventions]. ( Buchkremer, G; Franzen, U; Hornung, WP, 1994) |
| " There was a negative correlation between the daily dosage of phenothiazine and the percentages of the polyunsaturated fatty acids arachidonic acid and alpha-linolenic acid+eicosapentaenoic acid+docosahexaenoic acid in thrombocytes (r = -0." | 1.28 | Schizophrenic patients treated with high dose phenothiazine or thioxanthene become deficient in polyunsaturated fatty acids in their thrombocytes. ( Fischer, S; Kissling, W; Kuss, HJ, 1992) |
| "Rebound insomnia is one of the medical effects of reduction in dosage or discontinuation of neuroleptic drugs." | 1.27 | Rebound insomnia in neuroleptic drug withdrawal neurophysiologic characteristics. ( van Sweden, B, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (43.18) | 18.7374 |
| 1990's | 12 (27.27) | 18.2507 |
| 2000's | 10 (22.73) | 29.6817 |
| 2010's | 2 (4.55) | 24.3611 |
| 2020's | 1 (2.27) | 2.80 |
| Authors | Studies |
|---|---|
| Baumann, P | 1 |
| Eap, CB | 1 |
| Gastpar, M | 1 |
| Leucht, S | 3 |
| Helfer, B | 1 |
| Hartung, B | 3 |
| Schaller, G | 1 |
| Jacobi, A | 1 |
| Rotter, A | 1 |
| Kornhuber, J | 1 |
| Hillemacher, T | 1 |
| Kucharska-Pietura, K | 1 |
| Tylec, A | 1 |
| Czernikiewicz, A | 1 |
| Mortimer, A | 1 |
| Kowalski, J | 2 |
| Blada, P | 2 |
| Kucia, K | 2 |
| Lawniczek, T | 1 |
| Madej, A | 2 |
| Belowski, D | 1 |
| Herman, ZS | 2 |
| Nadeem, Z | 1 |
| McIntosh, A | 2 |
| Lawrie, S | 2 |
| Bohacek, N | 1 |
| Ohlmeier, MD | 1 |
| Jahn, K | 1 |
| Wilhelm-Gossling, C | 1 |
| Godecke-Koch, T | 1 |
| Hoffmann, J | 1 |
| Seifert, J | 1 |
| Emrich, HM | 1 |
| Schneider, U | 1 |
| Madle, S | 1 |
| Obe, G | 1 |
| Schroeter, H | 1 |
| Herha, J | 1 |
| Pietzcker, A | 6 |
| Schley, J | 5 |
| Siegert, M | 1 |
| Müller-Oerlinghausen, B | 7 |
| Poppenberg, A | 2 |
| Brinkschulte, M | 2 |
| Gaertner, HJ | 2 |
| Schied, HW | 5 |
| Breyer-Pfaff, U | 5 |
| Schmidt, LG | 2 |
| Schüssler, G | 1 |
| Kappes, CV | 1 |
| Rein, W | 4 |
| Straube, E | 3 |
| Jung, H | 1 |
| Naber, D | 2 |
| Nedopil, N | 1 |
| Eben, E | 1 |
| Hornung, WP | 1 |
| Franzen, U | 1 |
| Buchkremer, G | 1 |
| Hegerl, U | 3 |
| Juckel, G | 2 |
| Müller-Schubert, A | 2 |
| Gaebel, W | 6 |
| Volz, HP | 2 |
| Mackert, A | 2 |
| Diefenbacher, A | 1 |
| Friedrich, A | 1 |
| Müller, H | 1 |
| Stock, G | 1 |
| Möller, HJ | 1 |
| Klimke, A | 1 |
| Klieser, E | 1 |
| Lehmann, E | 1 |
| Miele, L | 1 |
| Roelcke, U | 1 |
| Hornstein, C | 1 |
| Hund, E | 1 |
| Schmitt, HP | 1 |
| Siess, R | 1 |
| Kaltenmaier, M | 1 |
| Fassler, J | 1 |
| Meinck, HM | 1 |
| Gaertner, I | 1 |
| Altendorf, K | 1 |
| Batra, A | 1 |
| Yagdiran, O | 1 |
| Haasen, C | 1 |
| Nika, E | 1 |
| Krausz, M | 1 |
| Petruch, F | 1 |
| Schüppel, R | 1 |
| Breyer, U | 1 |
| Chaskel, H | 1 |
| Urban, R | 1 |
| Fischer, S | 1 |
| Kissling, W | 1 |
| Kuss, HJ | 1 |
| Dieterle, DM | 1 |
| Müller-Spahn, F | 2 |
| Ackenheil, M | 2 |
| Dieterle, D | 1 |
| Meya, U | 1 |
| Renfordt, E | 1 |
| Straube, ER | 1 |
| van Sweden, B | 1 |
| Gutzman, H | 1 |
| Ulrich, G | 2 |
| Siemetzki, H | 1 |
5 reviews available for perazine and Schizophrenia
| Article | Year |
|---|---|
Perazine for schizophrenia.
Topics: Antipsychotic Agents; Humans; Perazine; Randomized Controlled Trials as Topic; Schizophrenia | 2014 |
Schizophrenia.
Topics: Amisulpride; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; Cognitive Behavioral | 2003 |
Schizophrenia.
Topics: Amisulpride; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; Haloperidol; Humans; | 2004 |
Perazine for schizophrenia.
Topics: Antipsychotic Agents; Humans; Perazine; Randomized Controlled Trials as Topic; Schizophrenia | 2006 |
Perazine for schizophrenia.
Topics: Antipsychotic Agents; Humans; Perazine; Randomized Controlled Trials as Topic; Schizophrenia | 2002 |
8 trials available for perazine and Schizophrenia
| Article | Year |
|---|---|
Prediction and evaluation criteria in perazine therapy of acute schizophrenics: psychopathological results.
Topics: Acute Disease; Adolescent; Adult; Antipsychotic Agents; Clinical Trials as Topic; Female; Humans; Ma | 1983 |
Prediction and evaluation criteria in perazine therapy of acute schizophrenics. Methodological considerations, sample population, and research variables.
Topics: Acute Disease; Adolescent; Adult; Antipsychotic Agents; Arousal; Clinical Trials as Topic; Female; H | 1983 |
Prediction and evaluation criteria in perazine therapy of acute schizophrenics. Pharmacokinetic data.
Topics: Acute Disease; Adolescent; Adult; Antipsychotic Agents; Clinical Trials as Topic; Dose-Response Rela | 1983 |
Orthostatic challenge during neuroleptic test dose: a possible predictor of short-term outcome.
Topics: Adult; Arousal; Autonomic Nervous System; Blood Pressure; Brain; Female; Haloperidol; Heart Rate; Hu | 1994 |
Initial improvement as a criterion for drug choice in acute schizophrenia.
Topics: Adult; Brief Psychiatric Rating Scale; Double-Blind Method; Haloperidol; Humans; Perazine; Schizophr | 1993 |
[Relationship between perazine serum concentration and clinical results in long-term treated schizophrenic outpatients (author's transl)].
Topics: Adolescent; Adult; Antipsychotic Agents; Chronic Disease; Clinical Trials as Topic; Female; Humans; | 1978 |
[Effectiveness and tolerance of zotepine in a double-blind comparison with perazine in schizophrenic patients].
Topics: Adult; Antipsychotic Agents; Dibenzothiepins; Dose-Response Relationship, Drug; Double-Blind Method; | 1991 |
[Clinical effectiveness of zotepine in treatment of negative schizophrenic symptoms. Results of an open and a double-blind controlled trial].
Topics: Adult; Antipsychotic Agents; Arousal; Attention; Dibenzothiepins; Dose-Response Relationship, Drug; | 1991 |
31 other studies available for perazine and Schizophrenia
| Article | Year |
|---|---|
The effect of perazine on the CYP2D6 and CYP2C19 phenotypes as measured by the dextromethorphan and mephenytoin tests in psychiatric patients.
Topics: Adult; Antipsychotic Agents; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP | 2020 |
Perazine elevates clozapine serum levels by inhibiting hepatic metabolism.
Topics: Clozapine; Drug Interactions; Female; Humans; Liver; Middle Aged; Perazine; Schizophrenia | 2009 |
Attentional and emotional functioning in schizophrenia patients treated with conventional and atypical antipsychotic drugs.
Topics: Adult; Amisulpride; Analysis of Variance; Antipsychotic Agents; Attention; Benzodiazepines; Dibenzot | 2012 |
In-vitro immunomodulatory effects of haloperidol and perazine in schizophrenia.
Topics: Adjuvants, Immunologic; Adult; CD4 Antigens; CD8 Antigens; Cells, Cultured; Dopamine Antagonists; Fe | 2000 |
[Therapeutic effects of butyrilperazine].
Topics: Antipsychotic Agents; Humans; Perazine; Psychotic Disorders; Schizophrenia | 1964 |
Perazine and carbamazepine in comparison to olanzapine in schizophrenia.
Topics: Adolescent; Adult; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Carbamazepine; Drug Thera | 2007 |
Possible mutagenicity of the psychoactive phenothiazine derivative perazine in vivo and in vitro.
Topics: Adolescent; Adult; Aged; Animals; Antipsychotic Agents; Cell Line; Cells, Cultured; Chromosome Aberr | 1980 |
Binding of perazine to alpha 1-acid glycoprotein.
Topics: Antipsychotic Agents; Chromatography, Gel; Humans; Immunoelectrophoresis; Orosomucoid; Perazine; Sch | 1980 |
Outcome and risks of ultra-long-term treatment with an oral neuroleptic drug. Relationship between perazine serum levels and clinical variables in schizophrenic outpatients.
Topics: Adult; Aged; Antipsychotic Agents; Dose-Response Relationship, Drug; Female; Humans; Long-Term Care; | 1981 |
Plasma protein binding of perazine and amitriptyline in psychiatric patients.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antipsychotic Agents; Blood Proteins; Depressive Disorder; F | 1982 |
[Comparison of higher-dose haloperidol therapy with perazine standard therapy in acute schizophrenic patients].
Topics: Acute Disease; Adult; Antipsychotic Agents; Dose-Response Relationship, Drug; Double-Blind Method; H | 1982 |
No correlation between neuroleptic-induced increase of beta-endorphin serum level and therapeutic efficacy in schizophrenia.
Topics: Adult; Antipsychotic Agents; beta-Endorphin; Endorphins; Female; Haloperidol; Humans; Male; Penfluri | 1984 |
The outpatient clinic for patients under chronic lithium or neuroleptic treatment as a phase-IV research tool.
Topics: Adult; Aged; Antipsychotic Agents; Blood Glucose; Clinical Trials as Topic; Depressive Disorder; Hum | 1984 |
[Perazine therapy. Seminar, Hamburg, 12-14 November 1992].
Topics: Antipsychotic Agents; Humans; Perazine; Schizophrenia | 1993 |
[Experiences of schizophrenic patients in ambulatory care with oral neuroleptics--baseline for psychoeducational interventions].
Topics: Adaptation, Psychological; Administration, Oral; Adult; Ambulatory Care; Chronic Disease; Clozapine; | 1994 |
Schizophrenics with small P300: a subgroup with a neurodevelopmental disturbance and a high risk for tardive dyskinesia?
Topics: Adult; Age of Onset; Biperiden; Clozapine; Dyskinesia, Drug-Induced; Evoked Potentials; Female; Foll | 1995 |
"Sunbath polyneuritis": subacute axonal neuropathy in perazine-treated patients after intense sun exposure.
Topics: Adult; Aged; Chronic Disease; Facial Paralysis; Female; Heliotherapy; Humans; Male; Neural Conductio | 1996 |
Residual symptoms and P300 in schizophrenic outpatients.
Topics: Adult; Antipsychotic Agents; Clozapine; Cognition Disorders; Evoked Potentials; Female; Follow-Up St | 1996 |
Relevance of liver enzyme elevations with four different neuroleptics: a retrospective review of 7,263 treatment courses.
Topics: Alanine Transaminase; Antipsychotic Agents; Aspartate Aminotransferases; Chi-Square Distribution; Cl | 2001 |
Neuroleptics normalize increased release of interleukin- 1 beta and tumor necrosis factor-alpha from monocytes in schizophrenia.
Topics: Adult; Antipsychotic Agents; Enzyme-Linked Immunosorbent Assay; Female; Haloperidol; Humans; Interle | 2001 |
Switching to amisulpride due to hepatic complications.
Topics: Adult; Amisulpride; Antipsychotic Agents; Chemical and Drug Induced Liver Injury; Flupenthixol; Halo | 2002 |
[Changes in drug elimination under the influence of perazine therapy (author's transl)].
Topics: Antipsychotic Agents; Antipyrine; Humans; Kinetics; Liver; Male; Perazine; Schizophrenia | 1976 |
Early serum levels of neuroleptics do not predict therapeutic response in schizophrenia.
Topics: Adult; Aged; Antipsychotic Agents; Female; Humans; Male; Middle Aged; Perazine; Phenothiazines; Schi | 1992 |
Schizophrenic patients treated with high dose phenothiazine or thioxanthene become deficient in polyunsaturated fatty acids in their thrombocytes.
Topics: Adult; Blood Platelets; Fatty Acids; Fatty Acids, Unsaturated; Female; Flupenthixol; Humans; Male; M | 1992 |
[Cardiovascular irregularities in schizophrenia--more than an epiphenomenon?].
Topics: Arousal; Autonomic Nervous System; Blood Pressure; Dopamine; Electrocardiography; Heart Rate; Humans | 1991 |
Can changes in eye-contacts predict therapeutic outcome in schizophrenic patients undergoing neuroleptic treatment? Results of a preliminary study.
Topics: Antipsychotic Agents; Eye Movements; Haloperidol; Humans; Interviews as Topic; Nonverbal Communicati | 1986 |
Autonomic nervous system differences as predictors of short-term outcome in schizophrenics.
Topics: Adult; Antipsychotic Agents; Arousal; Attention; Female; Humans; Male; Perazine; Prognosis; Psychiat | 1987 |
Rebound insomnia in neuroleptic drug withdrawal neurophysiologic characteristics.
Topics: Adult; Antipsychotic Agents; Arousal; Chlorprothixene; Dose-Response Relationship, Drug; Electroence | 1987 |
Auditory evoked potentials as possible predictors of outcome in schizophrenic outpatients.
Topics: Adult; Antipsychotic Agents; Clozapine; Dibenzazepines; Evoked Potentials, Auditory; Female; Humans; | 1988 |
[A differential effect profile of neuroleptic therapy of acute schizophrenic patients? Results of a clinico-naturalistic study].
Topics: Acute Disease; Adult; Antipsychotic Agents; Drug Therapy, Combination; Female; Haloperidol; Humans; | 1988 |
Predictors of neuroleptic treatment response in acute schizophrenia: results of a treatment study with perazine.
Topics: Acute Disease; Adult; Antipsychotic Agents; Female; Humans; Male; Perazine; Prognosis; Psychiatric S | 1988 |