perampanel and Bradycardia

There is no pediatric overdose information available for perampanel. We present twocases involving children 2 years of age. A female ingested 0.77mg/kg perampanel anddeveloped drowsiness and ataxia within an hour, followed by bradycardia after 6 hours.She was admitted to the pediatric intensive care unit and given fluids and was thendischarged after 20 hours. The other case involved a male who ingested 0.25mg/kgperampanel and developed ataxia within an hour, eventually he was discharged after 6hour observation in the emergency department without any treatment.

Topics: Anticonvulsants; Ataxia; Bradycardia; Child, Preschool; Drug Overdose; Fatigue; Female; Humans; Male; Nitriles; Pyridones