peramivir and Retinal-Detachment

We herein report a case of a 31-year-old Japanese man who simultaneously had a positive influenza A virus antigen test result and Vogt-Koyanagi-Harada disease (VKHD), demonstrated by both diffuse multiple early hyperfluorescent points on fluorescein fundus photography and serous retinal detachments on optical coherence tomography. He had meningitis. It was difficult to determine whether the main cause of meningitis was influenza A or VKHD. After initial treatment with peramivir for influenza A and then methylprednisolone pulse with subsequent corticosteroid therapy for VKHD, his symptoms improved gradually. These findings suggest that influenza A virus infection contributes to the onset or exacerbation of VKHD.

Topics: Acids, Carbocyclic; Adult; Antiviral Agents; Cyclopentanes; Glucocorticoids; Guanidines; Humans; Influenza A virus; Influenza, Human; Male; Methylprednisolone; Retinal Detachment; Tomography, Optical Coherence; Uveomeningoencephalitic Syndrome