peptones and Cell-Transformation--Neoplastic

peptones has been researched along with Cell-Transformation--Neoplastic* in 2 studies

Other Studies

2 other study(ies) available for peptones and Cell-Transformation--Neoplastic

Article	Year
Anti-inflammatory consequences of transplanted tumors. Advances in experimental medicine and biology, 1979, Volume: 121B Rats and mice bearing transplanted chemically induced neoplasms have defective macrophage infiltration of inflammatory sites distant to the tumor. The defect limits concurrently accumulation of macrophages within the tumor, raising dramatically the tumor to macrophage cell ratio. The defect may not compromise host surveillance because it requires relatively large numbers of tumor cells. The abnormality does not appear to result from circulating monocyte depletion, defective monocyte chemotaxis, or the traffic of monocytes into the tumor. Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Movement; Cell Transformation, Neoplastic; Chemotaxis; Fibrosarcoma; Inflammation; Macrophages; Monocytes; Neoplasm Transplantation; Peptones; Rats	1979
An inhibitor of cell proliferation released by cultures of macrophages. Proceedings of the National Academy of Sciences of the United States of America, 1974, Volume: 71, Issue:11 Culture fluids from mouse peritoneal exudate cells inhibited [(3)H]thymidine incorporation by, and proliferation of, EL-4 leukemia cells, 3T3 cells, and mitogen-stimulated spleen lymphocytes. Inhibited EL-4 leukemia cells recovered their normal proliferative capacity when washed and incubated in normal medium. The inhibitory activity resided in a low-molecular-weight substance that could be absorbed by incubation with the tumor cells. This substance was dialyzable and resistant to tryptic digestion and phosphodiesterase treatment. The mononuclear phagocytes in the peritoneal exudate seemed to be the source of the inhibitor. The inhibitory material was found in the same amounts in exudates of normal mice or mice injected with peptone or infected with Listeria monocytogenes; spleen cells adherent to plastic released the inhibitor but in lesser amount. We suggest that this inhibitor may contribute to the deleterious effects found when various cells, including neoplastic ones, are cultured in the presence of macrophages. Topics: Animals; Antigens, Bacterial; Cell Adhesion; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Fibroblasts; Immunization; Kinetics; Leukemia, Experimental; Listeria monocytogenes; Macrophages; Mice; Mice, Inbred C57BL; Mitosis; Peptones; Spleen; Thymidine; Tritium	1974

Article

Year

Anti-inflammatory consequences of transplanted tumors.

Advances in experimental medicine and biology, 1979, Volume: 121B

Rats and mice bearing transplanted chemically induced neoplasms have defective macrophage infiltration of inflammatory sites distant to the tumor. The defect limits concurrently accumulation of macrophages within the tumor, raising dramatically the tumor to macrophage cell ratio. The defect may not compromise host surveillance because it requires relatively large numbers of tumor cells. The abnormality does not appear to result from circulating monocyte depletion, defective monocyte chemotaxis, or the traffic of monocytes into the tumor.

Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Movement; Cell Transformation, Neoplastic; Chemotaxis; Fibrosarcoma; Inflammation; Macrophages; Monocytes; Neoplasm Transplantation; Peptones; Rats

1979

An inhibitor of cell proliferation released by cultures of macrophages.

Proceedings of the National Academy of Sciences of the United States of America, 1974, Volume: 71, Issue:11

Culture fluids from mouse peritoneal exudate cells inhibited [(3)H]thymidine incorporation by, and proliferation of, EL-4 leukemia cells, 3T3 cells, and mitogen-stimulated spleen lymphocytes. Inhibited EL-4 leukemia cells recovered their normal proliferative capacity when washed and incubated in normal medium. The inhibitory activity resided in a low-molecular-weight substance that could be absorbed by incubation with the tumor cells. This substance was dialyzable and resistant to tryptic digestion and phosphodiesterase treatment. The mononuclear phagocytes in the peritoneal exudate seemed to be the source of the inhibitor. The inhibitory material was found in the same amounts in exudates of normal mice or mice injected with peptone or infected with Listeria monocytogenes; spleen cells adherent to plastic released the inhibitor but in lesser amount. We suggest that this inhibitor may contribute to the deleterious effects found when various cells, including neoplastic ones, are cultured in the presence of macrophages.

Topics: Animals; Antigens, Bacterial; Cell Adhesion; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Fibroblasts; Immunization; Kinetics; Leukemia, Experimental; Listeria monocytogenes; Macrophages; Mice; Mice, Inbred C57BL; Mitosis; Peptones; Spleen; Thymidine; Tritium

1974