pepstatin has been researched along with Hepatitis-C* in 1 studies
1 other study(ies) available for pepstatin and Hepatitis-C
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Synthesis of dammarane-type triterpene derivatives and their ability to inhibit HIV and HCV proteases.
We synthesized dammarane-type triterpene derivatives and evaluated their ability to inhibit HIV-1 and HCV proteases to understand their structure-activity relationships. All of the mono- and di-succinyl derivatives (5a-5f) were powerful inhibitors of HIV-1 protease (IC(50)<10 microM). However, only di-succinyl (5e) and 2,3-seco-2,3-dioic acid (3b) derivatives similarly inhibited HCV protease (IC(50)<10 microM). A-nor dammarane-type triterpenes (4a and 4b, IC(50) 10.0 and 29.9 microM, respectively) inhibited HIV-1 protease moderately or strongly, but were inactive against HCV protease. All compounds that powerfully inhibited HIV-1 or HCV protease did not appreciably inhibit the general human proteases, renin and trypsin (IC(50)>1000 microM). These findings indicated that the mono-succinyl dammarane type derivatives (5a-5d) selectively inhibited HIV-1 protease and that the di-succinyl (5e, 5f) as well as 2,3-seco-2,3-dioic acid (3b) derivatives preferably inhibited both viral proteases. Topics: Anti-HIV Agents; Hepacivirus; Hepatitis C; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Protease Inhibitors; Renin; Structure-Activity Relationship; Triterpenes; Trypsin | 2009 |