pepstatin has been researched along with Chemical-and-Drug-Induced-Liver-Injury* in 1 studies
1 other study(ies) available for pepstatin and Chemical-and-Drug-Induced-Liver-Injury
| Article | Year |
|---|---|
Release of sialyltransferases from rat liver Golgi membranes by a cathepsin D-like proteinase: comparison of the release of Gal beta 1-4GlcNAc alpha 2-6 sialyltransferase, Gal beta 1-3(4)GlcNAc alpha 2-3 sialyltransferase and lactosylceramide alpha 2-3 si
The activities of Gal beta 1-3(4)GlcNAc alpha 2-3 sialyltransferase and SAT-1 were measured in rat liver Golgi in inflammation; both enzymes decreased by about 50%. This compares with increases of about 3-fold for the Gal beta 1-4GlcNAc alpha 2-6 sialyltransferase. All three sialyltransferases were released from disrupted Golgi membranes by incubation at reduced pH which activates an endogenous cathepsin D which is believed to be the lysosomal enzyme. Pepstatin A was found to block the release of all three sialyltransferases providing support for the role of cathepsin D as the proteinase that clips the catalytic portions of the enzymes from their membrane anchor and stem regions. Topics: Animals; beta-D-Galactoside alpha 2-6-Sialyltransferase; beta-Galactoside alpha-2,3-Sialyltransferase; Carbohydrate Sequence; Cathepsin D; Chemical and Drug Induced Liver Injury; Golgi Apparatus; Hydrogen-Ion Concentration; Lysosomes; Molecular Sequence Data; Pepstatins; Protein Structure, Tertiary; Rats; Sialyltransferases; Turpentine | 1995 |