peplomycin and Rhabdomyosarcoma

A rare case of prostatic rhabdomyosarcoma in a 3-year-old child is presented. He received a multimodal treatment of chemotherapy including vincristine, cyclophosphamide, actinomycin-D plus adriamycin, and linac irradiation followed by total prostatectomy with segmental resection of bladder. Despite no viable sarcoma cells in the surgical specimen, he showed relapse 4 months later. By the combination of cisplatin, vinblastine and peplomycin (PVP therapy), the bulky mass in the pelvis rapidly reduced by 95%. Furthermore, cisplatin, etoposide and peplomycin (PEP therapy), instead of PVP therapy, were administered to the refractory disease. Although the residual tumor was salvaged after 7 courses of PEP therapy, abdominal dissemination and liver metastasis occurred 2 months postoperatively. The combined modality of vincristine, peplomycin, ifosfamide, methotrexate, adriamycin, melphalan plus nimustine, and irradiation of microtron were effective for the abdominal dissemination, but he died of cerebral hemorrhage 31 months after the start of treatment. We emphasize that more aggressive chemotherapy including cisplatin, etoposide and so on is required to manage the advanced, relapsed, or resistant cases compared to the usual modality of rhabdomyosarcoma.

Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Etoposide; Humans; Male; Neoplasm Recurrence, Local; Peplomycin; Peptichemio; Prednisone; Prostatic Neoplasms; Rhabdomyosarcoma; Vincristine

Multi-drug combination therapy with CDDP, 5-FU and PEP was performed in 23 patients with malignant tumors in the head and neck region, and 2 CR patients and 9 PR patients were obtained with a response rate of 47.8%. The present therapy (CFP therapy) is considered to be especially effective against patients at low performance status grades with poorly differentiated squamous cell carcinoma which is located in regions receiving an abundant blood supply like the oral cavity. It is advisable to perform more than 2 courses of treatment as an induction chemotherapy. With respect to the method of administration of PEP, further study will be made in the future.

Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squamous Cell; Cisplatin; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Male; Middle Aged; Peplomycin; Rhabdomyosarcoma

The different forms of 57cobalt-bleomycin (57C0-blm) A2 and B2 as well as 57Co-pepleomycin (57Co-pep), were investigated in tumour-localizing properties of both forms of 57Co-blm are identical if 57Co-blm is injected as a bleomycin solution without carrier cobalt. Differences between the biological behaviour of the various cobalt complexes (which differ in ligand arrangement) were found if these complexes were injected together with inactive cobalt bleomycin complexes of the same form. In this case Co-blm B2 form I and Co-pep form I localize better than Co-blm b2 form II and Co-pep form II respectively. Such a decrease in uptake by the tumour, compared with form I, was not observed for Co-blm A2-II.

Topics: Absorption; Analysis of Variance; Animals; Antibiotics, Antineoplastic; Bleomycin; Cobalt Radioisotopes; Peplomycin; Rats; Rhabdomyosarcoma; Sarcoma, Experimental; Tissue Distribution