Compounds > peplomycin

peplomycin and Genital-Neoplasms--Female

peplomycin has been researched along with Genital-Neoplasms--Female* in 4 studies

Trials

1 trial(s) available for peplomycin and Genital-Neoplasms--Female

Article	Year
[Combination chemotherapy of peplomycin, vincristine, mitomycin C, and cisplatin in gynecologic carcinomas]. Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:10 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Genital Neoplasms, Female; Humans; Middle Aged; Mitomycin; Peplomycin; Uterine Cervical Neoplasms; Vincristine; Vulvar Neoplasms	1994

Other Studies

3 other study(ies) available for peplomycin and Genital-Neoplasms--Female

Article	Year
[Effect of hydrocortisone in the control of nausea and vomiting during CAP therapy]. Nihon Sanka Fujinka Gakkai zasshi, 1986, Volume: 38, Issue:11 Topics: Aclarubicin; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Female; Genital Neoplasms, Female; Humans; Hydrocortisone; Middle Aged; Naphthacenes; Nausea; Peplomycin; Vomiting	1986
[Peplomycin and cis-dichlorodiamineplatinum sensitivity of various kinds of human gynecological tumor cells in vitro]. Nihon Gan Chiryo Gakkai shi, 1985, Aug-20, Volume: 20, Issue:7 Topics: Adenocarcinoma; Bleomycin; Carcinoma, Squamous Cell; Cisplatin; Female; Genital Neoplasms, Female; Humans; Melanoma; Peplomycin; Tumor Stem Cell Assay	1985
[Peplomycin sensitivity of various types of human gynecological cultured tumor cells]. Nihon Sanka Fujinka Gakkai zasshi, 1984, Volume: 36, Issue:10 Various types of human gynecological cultured tumor cells were tested for the sensitivity to Peplomycin (PEP), an effective antitumor antibiotic for squamous cell carcinomas, by the regrowth assay method together with morphological observation. Bleomycin-hydrolase activity of these cell lines was also compared in cell-free extracts by assaying the conversion of Bleomycin into its deamidated from (HPLC method). SKG-I, SKG-II, SKG-IIIb cells derived from squamous cell carcinoma of the cervix and RKN cells derived from myosarcoma of the ovary were much more sensitive to PEP than other cell lines. PEP was found to be mainly a time-dependent drug, but also concentration dependent. The effect of PEP on cell morphology was characterized by the appearance of enlarged cells and swelling nuclei. The specific activities of Bleomycin-hydrolase in SKG-I, SKG-II, SKG-IIIb cells were shown to be relatively lower than that in other cell lines. These results suggested that cervical squamous carcinoma cells and ovarian myosarcoma cells were sensitive to PEP and Bleomycin-hydrolase activity was one of factors which decided the PEP sensitivity of human cultured tumor cells. Topics: Antibiotics, Antineoplastic; Bleomycin; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Resistance; Female; Genital Neoplasms, Female; Humans; Ovarian Neoplasms; Peplomycin; Uterine Cervical Neoplasms; Uterine Neoplasms	1984