peplomycin and Carcinoma--Basal-Cell

Both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are very common in skin malignancy. Operative therapy is the first choice at the treatment for SCC and BCC in early stage. After excision for large skin tumor, occasionally we use skin flap or musculocutaneous flap or free flap. At the old patient of Stage III and IV SCC and BCC, sometimes reduction surgery is useful at the combination therapy. Radiation as adjuvant therapy is sometimes useful for not only SCC but also BCC. The clinical efficacy of CA (C' A') chemotherapy (CDDP, ADM or CBDCA, EPI-ADM), was evaluated on Stage III, IV SCC and BCC. The response rate was 63% in SCC and 75% in BCC.

Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Female; Humans; Lung Neoplasms; Lymph Node Excision; Male; Middle Aged; Palliative Care; Peplomycin; Prognosis; Radiotherapy, Adjuvant; Skin Neoplasms; Skin Transplantation; Surgical Flaps

In Japan the regimen with peplomycin has been mainly used for the treatment of squamous cell carcinoma (SCC). But recently, a regimen with cisplatin, particularly the combination of cisplatin and adriamycin (CA chemotherapy) has been used for the treatment of SCC, and a better prognosis has resulted Since CA chemotherapy is very effective for not only SCC, but also basal cell carcinoma (BCC), we think it is a prominent neoadjuvant therapy for SCC and BCC. We have used CA chemotherapy for multiple lung metastasis of BCC over the past six years, and three times PR was obtained, with survival so far.

Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Drug Administration Schedule; Female; Humans; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Peplomycin; Skin Neoplasms