pep005 has been researched along with Pancreatic-Neoplasms* in 1 studies
1 other study(ies) available for pep005 and Pancreatic-Neoplasms
| Article | Year |
|---|---|
Ingenol mebutate inhibits the growth of pancreatic cancer cells in vitro via STING with an efficacy comparable to that of clinically used anticancer agents.
Pancreatic cancer is associated with a poor prognosis; thus, there is an urgent need to develop new and effective treatments. Ingenol mebutate (IM), which is isolated from the latex of Euphorbia peplus, was recently shown to be effective against pancreatic cancer cell lines; however, its mechanism of action has not been fully elucidated. In this study, we focused on the less drug-sensitive pancreatic cancer cell line Panc-1 and compared IM to commercially available anticancer drugs using cell survival assays. In addition, we aimed to identify novel biomolecules that may be involved in the mechanism of action of IM using RNA sequencing, western blotting, and inhibition assays. The IC Topics: Antineoplastic Agents; Cell Line, Tumor; Euphorbia; Humans; Pancreatic Neoplasms | 2023 |