peoniflorin has been researched along with Silicosis* in 1 studies
1 other study(ies) available for peoniflorin and Silicosis
| Article | Year |
|---|---|
Uncovering mechanisms of Baojin Chenfei formula treatment for silicosis by inhibiting inflammation and fibrosis based on serum pharmacochemistry and network analysis.
Baojin Chenfei formula (BCF), a Chinese herbal formula, has significant effects on improving the clinical symptoms of patients with silicosis. However, its active compounds and the underlying mechanisms have not yet fully been elucidated.. This study aimed to explore the underlying mechanisms of BCF in treating silicosis.. The rat model of silicosis was developed via a single intratracheal instillation of SiO. BCF significantly alleviated SiO. Active compounds of BCF, such as glycyrrhetic acid and paeoniflorin, could suppress inflammatory response by the MAPK pathway and suppress fibroblast activation by the EGFR-PI3K-AKT pathway. These might be the mechanisms of BCF in treating silicosis. Topics: Animals; Drugs, Chinese Herbal; ErbB Receptors; Fibrosis; Glycyrrhetinic Acid; Inflammation; Molecular Docking Simulation; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Silicon Dioxide; Silicosis | 2023 |