pentylenetetrazole has been researched along with Tauopathies in 2 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Tauopathies: Neurodegenerative disorders involving deposition of abnormal tau protein isoforms (TAU PROTEINS) in neurons and glial cells in the brain. Pathological aggregations of tau proteins are associated with mutation of the tau gene on chromosome 17 in patients with ALZHEIMER DISEASE; DEMENTIA; PARKINSONIAN DISORDERS; progressive supranuclear palsy (SUPRANUCLEAR PALSY, PROGRESSIVE); and corticobasal degeneration.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The employment of different dosage groups enabled us to characterize the dose range reliably inducing seizures." | 1.56 | Pentylenetetrazole-induced Seizure Susceptibility in the Tau58/4 Transgenic Mouse Model of Tauopathy. ( De Deyn, PP; Valkenburg, F; Van Dam, D; Van Erum, J, 2020) |
| "Epileptic seizures constitute a significant comorbidity of Alzheimer's disease (AD), which are recapitulated in transgenic mouse models of amyloidogenesis." | 1.56 | Hyperexcitability and seizures in the THY-Tau22 mouse model of tauopathy. ( Basquin, M; Blum, D; Boison, D; Buée, L; Ferry, B; Gomez-Murcia, V; Laurent, C; Parrot, S; Sandau, U, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Van Erum, J | 1 |
| Valkenburg, F | 1 |
| Van Dam, D | 1 |
| De Deyn, PP | 1 |
| Gomez-Murcia, V | 1 |
| Sandau, U | 1 |
| Ferry, B | 1 |
| Parrot, S | 1 |
| Laurent, C | 1 |
| Basquin, M | 1 |
| Buée, L | 1 |
| Boison, D | 1 |
| Blum, D | 1 |
2 other studies available for pentylenetetrazole and Tauopathies
| Article | Year |
|---|---|
Pentylenetetrazole-induced Seizure Susceptibility in the Tau58/4 Transgenic Mouse Model of Tauopathy.
Topics: Animals; Brain; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy; Mice, Inbred | 2020 |
Hyperexcitability and seizures in the THY-Tau22 mouse model of tauopathy.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Electroencephalography; Mice, Inbred C57BL; Mice | 2020 |