pentylenetetrazole has been researched along with Sudden Unexpected Death in Epilepsy in 3 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Sudden Unexpected Death in Epilepsy: Sudden death in a patient with EPILEPSY associated with SEIZURES and seizure-related symptoms (e.g., APNEA; HYPOXEMIA) without other identifiable accidental causes (e.g., DROWNING; WOUNDS AND INJURIES).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The primary cause of seizure-induced death for all mice was apnea, as (1) apnea began during a seizure and continued for tens of minutes until terminal asystole, and (2) death was prevented by mechanical ventilation." | 8.02 | Postictal Death Is Associated with Tonic Phase Apnea in a Mouse Model of Sudden Unexpected Death in Epilepsy. ( Blizzard, EA; Goodkin, HP; Meisler, MH; Panchal, PS; Patel, MK; Richerson, GB; Saraf, P; Teran, FA; Wagley, PK; Wagnon, JL; Wengert, ER; Wenker, IC, 2021) |
| "The primary cause of seizure-induced death for all mice was apnea, as (1) apnea began during a seizure and continued for tens of minutes until terminal asystole, and (2) death was prevented by mechanical ventilation." | 4.02 | Postictal Death Is Associated with Tonic Phase Apnea in a Mouse Model of Sudden Unexpected Death in Epilepsy. ( Blizzard, EA; Goodkin, HP; Meisler, MH; Panchal, PS; Patel, MK; Richerson, GB; Saraf, P; Teran, FA; Wagley, PK; Wagnon, JL; Wengert, ER; Wenker, IC, 2021) |
| "New mouse models of epilepsy are needed to better understand the complex genetic architecture of seizures and to identify therapeutics." | 1.56 | Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility. ( Bell, TA; Dalton, KA; Gu, B; Hock, P; Miller, DR; Pan, Y; Pardo-Manuel de Villena, F; Philpot, BD; Shaw, GD; Shorter, JR; Williams, LH, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gu, B | 1 |
| Shorter, JR | 1 |
| Williams, LH | 1 |
| Bell, TA | 1 |
| Hock, P | 1 |
| Dalton, KA | 1 |
| Pan, Y | 1 |
| Miller, DR | 1 |
| Shaw, GD | 1 |
| Philpot, BD | 1 |
| Pardo-Manuel de Villena, F | 1 |
| Shen, Y | 1 |
| Ma, HX | 1 |
| Lu, H | 1 |
| Zhao, HT | 1 |
| Sun, JL | 1 |
| Cheng, Y | 1 |
| Zhang, HH | 1 |
| Wenker, IC | 1 |
| Teran, FA | 1 |
| Wengert, ER | 1 |
| Wagley, PK | 1 |
| Panchal, PS | 1 |
| Blizzard, EA | 1 |
| Saraf, P | 1 |
| Wagnon, JL | 1 |
| Goodkin, HP | 1 |
| Meisler, MH | 1 |
| Richerson, GB | 1 |
| Patel, MK | 1 |
3 other studies available for pentylenetetrazole and Sudden Unexpected Death in Epilepsy
| Article | Year |
|---|---|
Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility.
Topics: Animals; Chromosome Mapping; Collaborative Cross Mice; Convulsants; Disease Models, Animal; Epilepsy | 2020 |
Central deficiency of norepinephrine synthesis and norepinephrinergic neurotransmission contributes to seizure-induced respiratory arrest.
Topics: Acoustic Stimulation; Adrenergic alpha-1 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals | 2021 |
Postictal Death Is Associated with Tonic Phase Apnea in a Mouse Model of Sudden Unexpected Death in Epilepsy.
Topics: Animals; Apnea; Convulsants; Diaphragm; Electroencephalography; Electromyography; Epilepsy; Female; | 2021 |