pentylenetetrazole has been researched along with Sepsis in 2 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| " 24h later, animals were subjected to seizures by using either maximal electro shock or pentylenetetrazole." | 3.85 | Increase in seizure susceptibility in sepsis like condition explained by spiking cytokines and altered adhesion molecules level with impaired blood brain barrier integrity in experimental model of rats treated with lipopolysaccharides. ( Chakrabarti, A; Medhi, B; Modi, M; Saikia, UN; Sewal, RK, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sewal, RK | 1 |
| Modi, M | 1 |
| Saikia, UN | 1 |
| Chakrabarti, A | 1 |
| Medhi, B | 1 |
| Huang, WY | 1 |
| Lin, S | 1 |
| Chen, HY | 1 |
| Chen, YP | 1 |
| Chen, TY | 1 |
| Hsu, KS | 1 |
| Wu, HM | 1 |
2 other studies available for pentylenetetrazole and Sepsis
| Article | Year |
|---|---|
Increase in seizure susceptibility in sepsis like condition explained by spiking cytokines and altered adhesion molecules level with impaired blood brain barrier integrity in experimental model of rats treated with lipopolysaccharides.
Topics: Animals; Blood-Brain Barrier; Capillary Permeability; Cytokines; Disease Models, Animal; Disease Sus | 2017 |
NADPH oxidases as potential pharmacological targets against increased seizure susceptibility after systemic inflammation.
Topics: Animals; Cells, Cultured; Drug Delivery Systems; Enzyme Inhibitors; Inflammation; Lipopolysaccharide | 2018 |