pentylenetetrazole has been researched along with Sensitivity and Specificity in 10 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In our previous work the detectors of seizure onset were based on seizure-induced changes in signal power in the frequency range up to 100 Hz, while in this preliminary study we assess the feasibility of recording high frequency oscillations (HFOs) in the range up to 300 Hz noninvasively with scalp TCREs during PTZ-induced seizures." | 5.38 | Feasibility of recording high frequency oscillations with tripolar concentric ring electrodes during pentylenetetrazole-induced seizures in rats. ( Besio, WG; Liu, X; Makeyev, O; Medvedev, AV; Taveras, A; Troiano, D; Wang, L; Zhu, Z, 2012) |
| " Previously, we applied noninvasive transcranial focal stimulation via tripolar concentric ring electrodes on the scalp of rats after inducing seizures with pentylenetetrazole." | 3.78 | Sensor integration of multiple tripolar concentric ring electrodes improves pentylenetetrazole-induced seizure onset detection in rats. ( Besio, WG; Ding, Q; Kay, SM; Makeyev, O, 2012) |
| "Epilepsy is a chronic neurological condition, with over 30% of cases unresponsive to treatment." | 1.46 | Automated analysis of brain activity for seizure detection in zebrafish models of epilepsy. ( Copmans, D; de Witte, PAM; Hunyadi, B; Siekierska, A; Sourbron, J, 2017) |
| "In our previous work the detectors of seizure onset were based on seizure-induced changes in signal power in the frequency range up to 100 Hz, while in this preliminary study we assess the feasibility of recording high frequency oscillations (HFOs) in the range up to 300 Hz noninvasively with scalp TCREs during PTZ-induced seizures." | 1.38 | Feasibility of recording high frequency oscillations with tripolar concentric ring electrodes during pentylenetetrazole-induced seizures in rats. ( Besio, WG; Liu, X; Makeyev, O; Medvedev, AV; Taveras, A; Troiano, D; Wang, L; Zhu, Z, 2012) |
| "Our proposed algorithm for seizure prediction is based on the principle that seizure build-up is always preceded by constantly changing bursting levels." | 1.32 | Prediction of PTZ-induced seizures using wavelet-based residual entropy of cortical and subcortical field potentials. ( Al-Nashash, H; Mirski, MA; Patel, CB; Paul, JS; Sherman, DL; Zhang, N; Ziai, WC, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (60.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Hunyadi, B | 1 |
| Siekierska, A | 1 |
| Sourbron, J | 1 |
| Copmans, D | 1 |
| de Witte, PAM | 1 |
| Löscher, W | 1 |
| Lopez-Avila, V | 1 |
| Cooley, J | 1 |
| Urdahl, R | 1 |
| Thevis, M | 1 |
| Makeyev, O | 2 |
| Liu, X | 1 |
| Wang, L | 1 |
| Zhu, Z | 1 |
| Taveras, A | 1 |
| Troiano, D | 1 |
| Medvedev, AV | 1 |
| Besio, WG | 2 |
| Ding, Q | 1 |
| Kay, SM | 1 |
| Calcagni, ML | 1 |
| Giordano, A | 1 |
| Bruno, I | 1 |
| Parbonetti, G | 1 |
| Di Giuda, D | 1 |
| De Rossi, G | 1 |
| Troncone, L | 1 |
| Colicchio, G | 1 |
| Kaneko, K | 1 |
| Itoh, K | 1 |
| Berliner, LJ | 1 |
| Miyasaka, K | 1 |
| Fujii, H | 1 |
| Paul, JS | 1 |
| Patel, CB | 1 |
| Al-Nashash, H | 1 |
| Zhang, N | 1 |
| Ziai, WC | 1 |
| Mirski, MA | 1 |
| Sherman, DL | 1 |
| Getova, DP | 1 |
| Dimitrova, DS | 1 |
1 review available for pentylenetetrazole and Sensitivity and Specificity
| Article | Year |
|---|---|
Preclinical assessment of proconvulsant drug activity and its relevance for predicting adverse events in humans.
Topics: Animals; Anticonvulsants; Antiretroviral Therapy, Highly Active; Data Interpretation, Statistical; D | 2009 |
1 trial available for pentylenetetrazole and Sensitivity and Specificity
| Article | Year |
|---|---|
Ictal brain SPET during seizures pharmacologically provoked with pentylenetetrazol: a new diagnostic procedure in drug-resistant epileptic patients.
Topics: Adolescent; Adult; Cysteine; Drug Resistance; Electroencephalography; Epilepsy; Feasibility Studies; | 2002 |
8 other studies available for pentylenetetrazole and Sensitivity and Specificity
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Automated analysis of brain activity for seizure detection in zebrafish models of epilepsy.
Topics: Animals; Automation, Laboratory; Brain; Disease Models, Animal; Electroencephalography; Epilepsy; La | 2017 |
Determination of stimulants using gas chromatography/high-resolution time-of-flight mass spectrometry and a soft ionization source.
Topics: Caffeine; Central Nervous System Stimulants; Cocaine; Codeine; Dopamine Uptake Inhibitors; Equipment | 2012 |
Feasibility of recording high frequency oscillations with tripolar concentric ring electrodes during pentylenetetrazole-induced seizures in rats.
Topics: Animals; Biological Clocks; Brain; Convulsants; Electrodes, Implanted; Electroencephalography; Equip | 2012 |
Sensor integration of multiple tripolar concentric ring electrodes improves pentylenetetrazole-induced seizure onset detection in rats.
Topics: Algorithms; Animals; Diagnosis, Computer-Assisted; Electrodes; Electroencephalography; Equipment Des | 2012 |
Consequences of nitric oxide generation in epileptic-seizure rodent models as studied by in vivo EPR.
Topics: Analysis of Variance; Animals; Brain; Disease Models, Animal; Electron Spin Resonance Spectroscopy; | 2002 |
Prediction of PTZ-induced seizures using wavelet-based residual entropy of cortical and subcortical field potentials.
Topics: Algorithms; Animals; Cerebral Cortex; Electroencephalography; Electromagnetic Fields; Male; Pentylen | 2003 |
Effects of the anticholinesterase drug tacrine on the development of PTZ kindling and on learning and memory processes in mice.
Topics: Analysis of Variance; Animals; Avoidance Learning; Cholinesterase Inhibitors; Disease Models, Animal | 2000 |