pentylenetetrazole has been researched along with Pregnancy in 65 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The primary cause of seizure-induced death for all mice was apnea, as (1) apnea began during a seizure and continued for tens of minutes until terminal asystole, and (2) death was prevented by mechanical ventilation." | 8.02 | Postictal Death Is Associated with Tonic Phase Apnea in a Mouse Model of Sudden Unexpected Death in Epilepsy. ( Blizzard, EA; Goodkin, HP; Meisler, MH; Panchal, PS; Patel, MK; Richerson, GB; Saraf, P; Teran, FA; Wagley, PK; Wagnon, JL; Wengert, ER; Wenker, IC, 2021) |
| "Our findings indicate that the administration of nicotine may attenuate microglial activity and increase eclampsia-like seizure threshold in rat hippocampus through the α7 nicotinic receptor." | 7.83 | Nicotine increases eclampsia-like seizure threshold and attenuates microglial activity in rat hippocampus through the α7 nicotinic acetylcholine receptor. ( Bao, J; Han, X; Li, X; Liu, H; Liu, Y; Thakur, M; Ye, A, 2016) |
| "The purposes of this investigation were to determine the effect of pregnancy on the susceptibility of female rats to experimentally induced seizures and on the relationship between serum phenytoin concentration and antiseizure activity." | 7.67 | Kinetics of drug action in disease states III: Effect of pregnancy on the relationship between phenytoin concentration and antiseizure activity in rats. ( Chou, RC; Levy, G, 1984) |
| "The anticonvulsant potency of 2-propyl-2-pentenoic acid (2-en-VPA; trans isomer), a major metabolite of the antiepileptic valproic acid (VPA), was evaluated in different animal models of epilepsy and compared with the respective data for VPA." | 7.67 | Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy. ( Löscher, W; Marescaux, C; Nau, H; Vergnes, M, 1984) |
| "Eclampsia is characterized by high morbidity and mortality wordwide." | 5.51 | Magnesium sulfate attenuates brain edema by lowering AQP4 expression and inhibits glia-mediated neuroinflammation in a rodent model of eclampsia. ( Li, X; Liu, H; Yang, Y, 2019) |
| "LCM and LEV were both effective against seizures induced by PTZ." | 5.46 | Treatment with lacosamide impedes generalized seizures in a rodent model of cortical dysplasia. ( Alexopoulos, AV; Gonzalez-Martinez, J; Najm, IM; Nemes, AD; O'Dwyer, R; Ying, Z, 2017) |
| "Eclampsia, defined as unexplained seizure in a woman with preeclampsia, is a life-threatening complication of pregnancy with unclear etiology." | 5.40 | Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia. ( Chan, SL; Cipolla, MJ; Johnson, AC; LaMarca, B; Moseley, J; Nagle, KJ; Tremble, SM, 2014) |
| "It has been described that febrile seizures during infancy increase risk of subsequent non-febrile seizures during the adulthood." | 5.35 | Hyperthermic seizures and hyperthermia in immature rats modify the subsequent pentylenetetrazole-induced seizures. ( Gonzalez-Ramirez, M; Orozco-Suarez, SA; Rocha, L; Salgado-Ceballos, H, 2009) |
| "Following cocaine-induced seizures, intense c-fos induction was observed in piriform cortex, amygdala, and hippocampus." | 5.31 | Spatiotemporal analysis of Fos expression associated with cocaine- and PTZ-induced seizures in prenatally cocaine-treated rats. ( Keller, RW; Snyder-Keller, A, 2001) |
| "The primary cause of seizure-induced death for all mice was apnea, as (1) apnea began during a seizure and continued for tens of minutes until terminal asystole, and (2) death was prevented by mechanical ventilation." | 4.02 | Postictal Death Is Associated with Tonic Phase Apnea in a Mouse Model of Sudden Unexpected Death in Epilepsy. ( Blizzard, EA; Goodkin, HP; Meisler, MH; Panchal, PS; Patel, MK; Richerson, GB; Saraf, P; Teran, FA; Wagley, PK; Wagnon, JL; Wengert, ER; Wenker, IC, 2021) |
| "Our findings indicate that the administration of nicotine may attenuate microglial activity and increase eclampsia-like seizure threshold in rat hippocampus through the α7 nicotinic receptor." | 3.83 | Nicotine increases eclampsia-like seizure threshold and attenuates microglial activity in rat hippocampus through the α7 nicotinic acetylcholine receptor. ( Bao, J; Han, X; Li, X; Liu, H; Liu, Y; Thakur, M; Ye, A, 2016) |
| "Folic acid (FA) is physiologically important in mammals and is a common vitamin supplement used during pregnancy and lactation." | 3.83 | Gestational treatment of folic acid attenuates blood-brain barrier leakage in pregnant- and prepubertal rats after pentylenetetrazole-induced seizure. ( Caglayan, B; Kaptan, E; Oztas, B; Seker, FB; Yorulmaz, H, 2016) |
| " Intraperitoneal pentylenetetrazole injection did not induce any seizure activity in the control rats, although it elicited seizures of variable severity in the polymicrogyria rats." | 3.81 | Increased expression of GAP43 in interneurons in a rat model of experimental polymicrogyria. ( Matsui, K; Takano, T, 2015) |
| " We have previously reported the presence of SBH in a rodent model of low level hypothyroidism induced by maternal exposure to the goitrogen, propylthiouracil (PTU)." | 3.80 | Subcortical band heterotopia in rat offspring following maternal hypothyroxinaemia: structural and functional characteristics. ( Gilbert, ME; Goodman, JH; McCloskey, DP; Ramos, RL, 2014) |
| " The available experimental evidence and the safety of vit-C in pregnancy suggest the experimental use of ascorbic acid as a new and effective protective agent ethanol and PTZ-induced apoptotic neurodegeneration." | 3.77 | Vitamin C protects against ethanol and PTZ-induced apoptotic neurodegeneration in prenatal rat hippocampal neurons. ( Kim, MO; Koh, PO; Lee, HY; Naseer, MI; Park, MS; Ullah, I; Ullah, N, 2011) |
| " We have studied the susceptibility to bicuculline and pentylenetetrazol-induced seizures in developing 10-, 20- and 30-day old rats, gestationally exposed to cocaine." | 3.69 | Prenatal cocaine: seizure susceptibility in rat offspring. ( de Feo, MR; Del Priore, D; Mecarelli, O, 1995) |
| "The anticonvulsant potency of 2-propyl-2-pentenoic acid (2-en-VPA; trans isomer), a major metabolite of the antiepileptic valproic acid (VPA), was evaluated in different animal models of epilepsy and compared with the respective data for VPA." | 3.67 | Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy. ( Löscher, W; Marescaux, C; Nau, H; Vergnes, M, 1984) |
| "The purposes of this investigation were to determine the effect of pregnancy on the susceptibility of female rats to experimentally induced seizures and on the relationship between serum phenytoin concentration and antiseizure activity." | 3.67 | Kinetics of drug action in disease states III: Effect of pregnancy on the relationship between phenytoin concentration and antiseizure activity in rats. ( Chou, RC; Levy, G, 1984) |
| " In line with this hypothesis, it was found that three functional benzodiazepine antagonists (FG 7142, pentylenetetrazol, caffeine) decreased food intake, lowered aggression and strengthened freezing in lactating mother rats." | 3.67 | Behavioural similarities between mother rats and benzodiazepine-treated non-maternal animals. ( Ferreira, A; Hansen, S; Selart, ME, 1985) |
| "Treatment with finasteride increased seizure susceptibility and depression due to decreased progesterone and elevated estrogen levels coupled with decreased monoamine and elevated corticosterone levels." | 1.72 | Anticonvulsant Effect of Asparagus racemosus Willd. in a Mouse Model of Catamenial Epilepsy. ( Goel, RK; Pahwa, P; Singh, T, 2022) |
| "Epilepsy is a chronic brain disease affecting millions of people worldwide." | 1.62 | Environmental enrichment alters neurobehavioral development following maternal immune activation in mice offspring with epilepsy. ( Mosaferi, B; Najdi, N; Salari, AA; Zeraati, M, 2021) |
| "Increased behavioral manifestations and seizure severity was observed in the stress group compared with the control group at both ages." | 1.56 | Physical exercise during pregnancy minimizes PTZ-induced behavioral manifestations in prenatally stressed offspring. ( Arida, RM; da Silva, EA; Gutierre, RC; Lopim, GM, 2020) |
| "Reversible posterior leukoencephalopathy syndrome (RPLS) is a clinical-imaging syndrome as well as a critical maternal complication." | 1.56 | Contribution of excess inflammation to a possible rat model of eclamptic reversible posterior leukoencephalopathy syndrome induced by lipopolysaccharide and pentylenetetrazol: A preliminary study. ( Chen, D; Fang, X; Liang, Y; Liu, Y; Xie, M; Zhang, W, 2020) |
| "Eclampsia is characterized by high morbidity and mortality wordwide." | 1.51 | Magnesium sulfate attenuates brain edema by lowering AQP4 expression and inhibits glia-mediated neuroinflammation in a rodent model of eclampsia. ( Li, X; Liu, H; Yang, Y, 2019) |
| "LCM and LEV were both effective against seizures induced by PTZ." | 1.46 | Treatment with lacosamide impedes generalized seizures in a rodent model of cortical dysplasia. ( Alexopoulos, AV; Gonzalez-Martinez, J; Najm, IM; Nemes, AD; O'Dwyer, R; Ying, Z, 2017) |
| "Eclampsia is a poorly understood but potentially fatal complication of pregnancy." | 1.40 | Decreased seizure threshold in an eclampsia-like model induced in pregnant rats with lipopolysaccharide and pentylenetetrazol treatments. ( Brennecke, SP; Di, X; Hu, B; Huang, Q; Liu, H; Liu, L, 2014) |
| "Body weight was significantly higher in morphine groups than saline treated rats." | 1.40 | Effect of prenatal forced-swim stress and morphine co-administration on pentylentetrazol-induced epileptic behaviors in infant and prepubertal rats. ( Ebrahimi, L; Hashemi, P; Roshan-Milani, S; Saboory, E, 2014) |
| "Eclampsia, defined as unexplained seizure in a woman with preeclampsia, is a life-threatening complication of pregnancy with unclear etiology." | 1.40 | Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia. ( Chan, SL; Cipolla, MJ; Johnson, AC; LaMarca, B; Moseley, J; Nagle, KJ; Tremble, SM, 2014) |
| "Seizures were induced 30 min later using a chemoconvulsant (pentylenetetrazol, PTZ) model, which has been widely used to determine anticonvulsant efficacy of many other antiepileptic drugs in neonatal animals." | 1.38 | Anticonvulsant effect of retigabine during postnatal development in rats. ( Forcelli, PA; Gale, K; Kondratyev, A; Lakhkar, A; Soper, C, 2012) |
| " VCU was mainly eliminated by metabolism with a half-life of 2 h." | 1.36 | Evaluation of stereoselective anticonvulsant, teratogenic, and pharmacokinetic profile of valnoctylurea (capuride): a chiral stereoisomer of valproic acid urea derivative. ( Bialer, M; Finnell, RH; Schurig, V; Shimshoni, JA; Wlodarczyk, B; Yagen, B, 2010) |
| "Epilepsy is a prominent sign of neurological dysfunction in children with various fetal and maternal deficiencies." | 1.35 | Maternal epileptic seizure induced by pentylenetetrazol: apoptotic neurodegeneration and decreased GABAB1 receptor expression in prenatal rat brain. ( Kim, MO; Naseer, MI; Shupeng, L, 2009) |
| "The present study showed that epileptic seizures induced by convulsive PTZ challenge during kindling-mediated epileptogenesis in the presence of CD changed both functional and ultrastructural properties of the BBB and considerably enhanced transendothelial vesicular transport, while paracellular pathway was apparently not involved in this setting." | 1.35 | Morphological and functional changes of blood-brain barrier in kindled rats with cortical dysplasia. ( Ahishali, B; Arican, N; Bilgic, B; Ekizoglu, O; Elmas, I; Gurses, C; Kalayci, R; Kaya, M; Kemikler, G; Kucuk, M; Oku, B; Orhan, N; Ustek, D, 2008) |
| "It has been described that febrile seizures during infancy increase risk of subsequent non-febrile seizures during the adulthood." | 1.35 | Hyperthermic seizures and hyperthermia in immature rats modify the subsequent pentylenetetrazole-induced seizures. ( Gonzalez-Ramirez, M; Orozco-Suarez, SA; Rocha, L; Salgado-Ceballos, H, 2009) |
| "Following cocaine-induced seizures, intense c-fos induction was observed in piriform cortex, amygdala, and hippocampus." | 1.31 | Spatiotemporal analysis of Fos expression associated with cocaine- and PTZ-induced seizures in prenatally cocaine-treated rats. ( Keller, RW; Snyder-Keller, A, 2001) |
| " In the pups of all dosed groups, the convulsive threshold for PTZ is reduced significantly compared with that in the naive group." | 1.26 | Alteration of convulsive threshold and sensitivity to CNS acting drugs in sedative-hypnotics-experienced rat offspring. ( Hiramori, T; Nakao, K; Tagashira, E; Urano, T; Yanaura, S, 1982) |
| "Epileptiform convulsions occurred in presentation of "difficult" experimental tasks." | 1.26 | [Characteristics of the function of the higher portions of the central nervous system of rats subjected to acute hypoxia in the antenatal period]. ( Kruglikov, RI; Maĭzelis, MIa; Zabludovskiĭ, AL, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (40.00) | 18.7374 |
| 1990's | 7 (10.77) | 18.2507 |
| 2000's | 6 (9.23) | 29.6817 |
| 2010's | 20 (30.77) | 24.3611 |
| 2020's | 6 (9.23) | 2.80 |
| Authors | Studies |
|---|---|
| Pahwa, P | 1 |
| Singh, T | 1 |
| Goel, RK | 1 |
| Zhao, YC | 1 |
| Wang, CC | 1 |
| Li, XY | 1 |
| Wang, DD | 1 |
| Wang, YM | 1 |
| Xue, CH | 1 |
| Wen, M | 1 |
| Zhang, TT | 1 |
| Lopim, GM | 1 |
| Gutierre, RC | 1 |
| da Silva, EA | 1 |
| Arida, RM | 1 |
| Yavuz, M | 1 |
| Albayrak, N | 1 |
| Özgür, M | 1 |
| Gülçebi İdriz Oğlu, M | 1 |
| Çavdar, S | 1 |
| Onat, F | 1 |
| Fang, X | 1 |
| Liang, Y | 1 |
| Chen, D | 1 |
| Liu, Y | 2 |
| Xie, M | 1 |
| Zhang, W | 1 |
| Zeraati, M | 1 |
| Najdi, N | 1 |
| Mosaferi, B | 1 |
| Salari, AA | 1 |
| Wenker, IC | 1 |
| Teran, FA | 1 |
| Wengert, ER | 1 |
| Wagley, PK | 1 |
| Panchal, PS | 1 |
| Blizzard, EA | 1 |
| Saraf, P | 1 |
| Wagnon, JL | 1 |
| Goodkin, HP | 1 |
| Meisler, MH | 1 |
| Richerson, GB | 1 |
| Patel, MK | 1 |
| Paiva, DS | 1 |
| Romariz, SAA | 1 |
| Valente, MF | 1 |
| Moraes, LB | 1 |
| Covolan, L | 1 |
| Calcagnotto, ME | 1 |
| Monteiro Longo, B | 1 |
| Nemes, AD | 1 |
| O'Dwyer, R | 1 |
| Najm, IM | 2 |
| Ying, Z | 1 |
| Gonzalez-Martinez, J | 1 |
| Alexopoulos, AV | 2 |
| Li, X | 2 |
| Liu, H | 3 |
| Yang, Y | 1 |
| Ebrahimi, L | 2 |
| Saboory, E | 2 |
| Roshan-Milani, S | 2 |
| Hashemi, P | 2 |
| Tomonoh, Y | 1 |
| Deshimaru, M | 1 |
| Araki, K | 1 |
| Miyazaki, Y | 1 |
| Arasaki, T | 1 |
| Tanaka, Y | 1 |
| Kitamura, H | 1 |
| Mori, F | 1 |
| Wakabayashi, K | 1 |
| Yamashita, S | 1 |
| Saito, R | 1 |
| Itoh, M | 1 |
| Uchida, T | 1 |
| Yamada, J | 1 |
| Migita, K | 1 |
| Ueno, S | 1 |
| Kitaura, H | 1 |
| Kakita, A | 1 |
| Lossin, C | 1 |
| Takano, Y | 1 |
| Hirose, S | 1 |
| Huang, Q | 1 |
| Liu, L | 1 |
| Hu, B | 1 |
| Di, X | 1 |
| Brennecke, SP | 1 |
| Naseer, MI | 3 |
| Ullah, I | 2 |
| Rasool, M | 1 |
| Ansari, SA | 1 |
| Sheikh, IA | 1 |
| Bibi, F | 1 |
| Chaudhary, AG | 1 |
| Al-Qahtani, MH | 1 |
| Kim, MO | 3 |
| Gilbert, ME | 1 |
| Ramos, RL | 1 |
| McCloskey, DP | 1 |
| Goodman, JH | 1 |
| Takano, T | 1 |
| Matsui, K | 1 |
| Pourmotabbed, A | 1 |
| Mahmoodi, G | 1 |
| Mahmoodi, S | 1 |
| Mohammadi-Farani, A | 1 |
| Nedaei, SE | 1 |
| Pourmotabbed, T | 2 |
| Seker, FB | 1 |
| Yorulmaz, H | 1 |
| Kaptan, E | 1 |
| Caglayan, B | 1 |
| Oztas, B | 1 |
| Johnson, AC | 1 |
| Tremble, SM | 1 |
| Chan, SL | 1 |
| Moseley, J | 1 |
| LaMarca, B | 1 |
| Nagle, KJ | 1 |
| Cipolla, MJ | 1 |
| Han, X | 1 |
| Bao, J | 1 |
| Ye, A | 1 |
| Thakur, M | 1 |
| Soltanineghad, M | 1 |
| Oghlakian, RO | 1 |
| Tilelli, CQ | 1 |
| Hiremath, GK | 1 |
| Gonzalez-Ramirez, M | 1 |
| Salgado-Ceballos, H | 1 |
| Orozco-Suarez, SA | 1 |
| Rocha, L | 1 |
| Shupeng, L | 1 |
| Shimshoni, JA | 2 |
| Yagen, B | 2 |
| Wlodarczyk, B | 1 |
| Finnell, RH | 1 |
| Schurig, V | 1 |
| Bialer, M | 2 |
| Okada, A | 1 |
| Noyori, H | 1 |
| Fujiwara, M | 1 |
| Ullah, N | 1 |
| Koh, PO | 1 |
| Lee, HY | 1 |
| Park, MS | 1 |
| Forcelli, PA | 1 |
| Soper, C | 1 |
| Lakhkar, A | 1 |
| Gale, K | 1 |
| Kondratyev, A | 1 |
| Rajabzadeh, A | 1 |
| Bideskan, AE | 1 |
| Fazel, A | 1 |
| Sankian, M | 1 |
| Rafatpanah, H | 1 |
| Haghir, H | 1 |
| Xie, T | 1 |
| Wang, WP | 1 |
| Jia, LJ | 1 |
| Mao, ZF | 1 |
| Qu, ZZ | 1 |
| Luan, SQ | 1 |
| Kan, MC | 1 |
| LEAK, WN | 1 |
| POCKRANDT, H | 1 |
| BALTZER, H | 4 |
| KRAUS, HH | 2 |
| BREUNER, W | 1 |
| GEISER-RAUCH, D | 1 |
| VOINESCO, S | 1 |
| PETRESCO, A | 1 |
| SCHUMACHER, U | 1 |
| DIEKE, E | 1 |
| GESENIUS, H | 1 |
| NEUBART, P | 1 |
| Kaya, M | 1 |
| Gurses, C | 1 |
| Kalayci, R | 1 |
| Ekizoglu, O | 1 |
| Ahishali, B | 1 |
| Orhan, N | 1 |
| Oku, B | 1 |
| Arican, N | 1 |
| Ustek, D | 1 |
| Bilgic, B | 1 |
| Elmas, I | 1 |
| Kucuk, M | 1 |
| Kemikler, G | 1 |
| Löscher, W | 1 |
| Nau, H | 2 |
| Marescaux, C | 1 |
| Vergnes, M | 1 |
| Chou, RC | 1 |
| Levy, G | 2 |
| Tagashira, E | 1 |
| Nakao, K | 1 |
| Urano, T | 1 |
| Hiramori, T | 1 |
| Yanaura, S | 1 |
| da Silva, VA | 1 |
| Ribeiro, MJ | 1 |
| Masur, J | 1 |
| de Feo, MR | 1 |
| Del Priore, D | 1 |
| Mecarelli, O | 1 |
| Koff, JM | 1 |
| Miller, LG | 1 |
| De Riu, PL | 1 |
| Mameli, P | 1 |
| Becciu, A | 1 |
| Simula, ME | 1 |
| Mameli, O | 1 |
| Pomés, A | 1 |
| Rodríguez-Farré, E | 1 |
| Suñol, C | 1 |
| Snyder-Keller, A | 2 |
| Keller, RW | 2 |
| Castellanos, CA | 1 |
| Roldan, G | 1 |
| Gómez, C | 1 |
| Vargas-González, A | 1 |
| Galindo-Morales, JA | 1 |
| Roman-Ramos, R | 1 |
| Campos-Sepúlveda, AE | 1 |
| Zabludovskiĭ, AL | 1 |
| Maĭzelis, MIa | 1 |
| Kruglikov, RI | 1 |
| Hauck, RS | 1 |
| Elmazar, MM | 1 |
| Gavish, M | 1 |
| Avnimelech-Gigus, N | 1 |
| Feldon, J | 1 |
| Myslobodsky, M | 1 |
| Hansen, S | 1 |
| Ferreira, A | 1 |
| Selart, ME | 1 |
| Ramzan, IM | 1 |
| Morelli de Liberti, SA | 1 |
| de los Santos de Schaub, EB | 1 |
| Rodriquez de Turco, EB | 1 |
| Kolmodin, GM | 1 |
| Meyerson, BA | 1 |
| Browne, TR | 1 |
| Penry, JK | 1 |
| Ravel, R | 1 |
| Riekers, HG | 1 |
| Goldstein, BJ | 1 |
| Voith, K | 1 |
| Kovacs, BA | 1 |
1 review available for pentylenetetrazole and Pregnancy
| Article | Year |
|---|---|
Benzodiazepines in the treatment of epilepsy. A review.
Topics: Adult; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Disease Models, Animal; Eclampsia; Elec | 1973 |
64 other studies available for pentylenetetrazole and Pregnancy
| Article | Year |
|---|---|
Anticonvulsant Effect of Asparagus racemosus Willd. in a Mouse Model of Catamenial Epilepsy.
Topics: Animals; Anticonvulsants; Convulsants; Epilepsy, Reflex; Female; Horses; Mice; Pentylenetetrazole; P | 2022 |
Supplementation of n-3 PUFAs in Adulthood Attenuated Susceptibility to Pentylenetetrazol Induced Epilepsy in Mice Fed with n-3 PUFAs Deficient Diet in Early Life.
Topics: Animals; Diet; Dietary Supplements; Docosahexaenoic Acids; Epilepsy; Fatty Acids, Omega-3; Female; M | 2023 |
Physical exercise during pregnancy minimizes PTZ-induced behavioral manifestations in prenatally stressed offspring.
Topics: Animals; Behavior, Animal; Convulsants; Disease Models, Animal; Epilepsy; Female; Male; Pentylenetet | 2020 |
The effect of prenatal and postnatal caffeine exposure on pentylentetrazole induced seizures in the non-epileptic and epileptic offsprings.
Topics: Animals; Brain; Caffeine; Calcium Channels, T-Type; Epilepsy, Absence; Female; Male; Pentylenetetraz | 2019 |
Contribution of excess inflammation to a possible rat model of eclamptic reversible posterior leukoencephalopathy syndrome induced by lipopolysaccharide and pentylenetetrazol: A preliminary study.
Topics: Animals; Astrocytes; Blood Pressure; Blood-Brain Barrier; Brain; Disease Models, Animal; Eclampsia; | 2020 |
Environmental enrichment alters neurobehavioral development following maternal immune activation in mice offspring with epilepsy.
Topics: Animals; Anxiety; Behavior, Animal; Cognitive Dysfunction; Convulsants; Disease Models, Animal; Dise | 2021 |
Postictal Death Is Associated with Tonic Phase Apnea in a Mouse Model of Sudden Unexpected Death in Epilepsy.
Topics: Animals; Apnea; Convulsants; Diaphragm; Electroencephalography; Electromyography; Epilepsy; Female; | 2021 |
Transplantation of inhibitory precursor cells from medial ganglionic eminence produces distinct responses in two different models of acute seizure induction.
Topics: Acute Disease; Animals; Disease Models, Animal; Electroshock; Female; Hippocampus; Interneurons; Mal | 2017 |
Treatment with lacosamide impedes generalized seizures in a rodent model of cortical dysplasia.
Topics: Acetamides; Animals; Anticonvulsants; Electroencephalography; Female; GABA Antagonists; Lacosamide; | 2017 |
Magnesium sulfate attenuates brain edema by lowering AQP4 expression and inhibits glia-mediated neuroinflammation in a rodent model of eclampsia.
Topics: Animals; Aquaporin 4; Astrocytes; Brain Edema; CA3 Region, Hippocampal; Cytokines; Disease Models, A | 2019 |
Effect of prenatal forced-swim stress and morphine co-administration on pentylentetrazol-induced epileptic behaviors in infant and prepubertal rats.
Topics: Animals; Animals, Newborn; Body Weight; Female; Male; Morphine; Narcotics; Pentylenetetrazole; Pregn | 2014 |
The kick-in system: a novel rapid knock-in strategy.
Topics: Animals; Behavior, Animal; Embryonic Stem Cells; Epilepsy, Benign Neonatal; Female; Gene Expression | 2014 |
Decreased seizure threshold in an eclampsia-like model induced in pregnant rats with lipopolysaccharide and pentylenetetrazol treatments.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Eclampsia; Female; Humans; Lipopolysaccharides; Ma | 2014 |
Downregulation of dopamine D₁ receptors and increased neuronal apoptosis upon ethanol and PTZ exposure in prenatal rat cortical and hippocampal neurons.
Topics: Animals; Apoptosis; Blotting, Western; Cells, Cultured; Cerebral Cortex; Convulsants; Down-Regulatio | 2014 |
Subcortical band heterotopia in rat offspring following maternal hypothyroxinaemia: structural and functional characteristics.
Topics: Animals; Brain; Classical Lissencephalies and Subcortical Band Heterotopias; Dose-Response Relations | 2014 |
Increased expression of GAP43 in interneurons in a rat model of experimental polymicrogyria.
Topics: Animals; Animals, Newborn; Brain; Disease Models, Animal; Female; GAP-43 Protein; Ibotenic Acid; Int | 2015 |
Effect of central muscarinic receptors on passive-avoidance learning deficits induced by prenatal pentylenetetrazol kindling in male offspring.
Topics: Animals; Avoidance Learning; Brain; Female; Kindling, Neurologic; Learning Disabilities; Male; Musca | 2014 |
Gestational treatment of folic acid attenuates blood-brain barrier leakage in pregnant- and prepubertal rats after pentylenetetrazole-induced seizure.
Topics: Animals; Blood Pressure; Blood-Brain Barrier; Epilepsy; Female; Folic Acid; Glial Fibrillary Acidic | 2016 |
Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Convulsants; Diet, High-Fat; Disease Models, Anima | 2014 |
Nicotine increases eclampsia-like seizure threshold and attenuates microglial activity in rat hippocampus through the α7 nicotinic acetylcholine receptor.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Astrocytes; Blood Pressure; CA1 Region, Hippocampa | 2016 |
Interactive effects of prenatal exposure to restraint stress and alcohol on pentylenetetrazol-induced seizure behaviors in rat offspring.
Topics: Animals; Animals, Newborn; Corticosterone; Ethanol; Female; Male; Pentylenetetrazole; Pregnancy; Pre | 2016 |
Single injection of a low dose of pentylenetetrazole leads to epileptogenesis in an animal model of cortical dysplasia.
Topics: Age Factors; Animals; Animals, Newborn; Convulsants; Disease Models, Animal; Electroencephalography; | 2009 |
Hyperthermic seizures and hyperthermia in immature rats modify the subsequent pentylenetetrazole-induced seizures.
Topics: Animals; Animals, Newborn; Convulsants; Disease Models, Animal; Female; Fever; Male; Pentylenetetraz | 2009 |
Maternal epileptic seizure induced by pentylenetetrazol: apoptotic neurodegeneration and decreased GABAB1 receptor expression in prenatal rat brain.
Topics: Animals; Apoptosis; Brain; Caspase 3; Cyclic AMP-Dependent Protein Kinases; Cytochromes c; Electroen | 2009 |
Evaluation of stereoselective anticonvulsant, teratogenic, and pharmacokinetic profile of valnoctylurea (capuride): a chiral stereoisomer of valproic acid urea derivative.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug | 2010 |
Anticonvulsant profile and teratogenic evaluation of potent new analogues of a valproic acid urea derivative in NMRI mice.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Bone and Bones; Deep Sedation; Differential T | 2009 |
Vitamin C protects against ethanol and PTZ-induced apoptotic neurodegeneration in prenatal rat hippocampal neurons.
Topics: Animals; Apoptosis; Ascorbic Acid; Blotting, Western; Cells, Cultured; Central Nervous System Depres | 2011 |
Anticonvulsant effect of retigabine during postnatal development in rats.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Carbamates; Convulsants; Dose-Response Relationsh | 2012 |
The effect of PTZ-induced epileptic seizures on hippocampal expression of PSA-NCAM in offspring born to kindled rats.
Topics: Animals; Epilepsy; Female; Gene Expression Regulation, Developmental; Hippocampus; Kindling, Neurolo | 2012 |
Environmental enrichment restores cognitive deficits induced by prenatal maternal seizure.
Topics: Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Cell Count; Cognition Disorders; Convu | 2012 |
Asphyxia and stillbirth.
Topics: Asphyxia; Asphyxia Neonatorum; Ephedrine; Female; Humans; Infant, Newborn; Pentylenetetrazole; Pregn | 1953 |
[Clinical experiments with the ecbolic combination of cardiazol and sparteine].
Topics: Female; Humans; Labor, Obstetric; Pentylenetetrazole; Pregnancy; Sparteine; Work | 1954 |
[Labor acceleration by intravenous tokofinal-cardiazol injection and experiences with tokofinal in induced labor].
Topics: Female; Humans; Labor Onset; Labor, Induced; Labor, Obstetric; Oxytocin; Pentylenetetrazole; Pregnan | 1954 |
[Cardiazole-sparteine as an oxytocic].
Topics: Female; Humans; Labor, Obstetric; Oxytocics; Pentylenetetrazole; Pregnancy; Sparteine; Work | 1956 |
[New ecbolic spartichine].
Topics: Female; Humans; Labor, Obstetric; Pentylenetetrazole; Pregnancy; Quinine; Sparteine; Work | 1956 |
[Cardiazol-activated EEG in former eclampsia patients].
Topics: Eclampsia; Electroencephalography; Female; Humans; Pentylenetetrazole; Pregnancy | 1958 |
[Anatomico-clinical aspects of certain poorly classified encephalitides and perivenous encephalitides during diseases of panencephalitic nature].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Encephalitis; Female; Humans; Labor, Obstetric; Med | 1958 |
[Labor acceleration by intravenous orasthinor tokofinal-cardiazole mixed injection. (A report on 12 years experience with this method)].
Topics: Acceleration; Female; Humans; Labor, Obstetric; Oxytocin; Pentylenetetrazole; Pituitary Gland; Pitui | 1961 |
[ON THE USE OF THE "O.-C."-"T.-C."-"S.-C."-METHOD (I.V. MIXTURE OF ORASTHIN, TOKOFINAL OR SYNTOCINON WITH CARDIAZOL) FOR LABOR ACCELERATION IN TWIN DELIVERIES AND THE RELATION OF THIS TYPE OF DELIVERY TO UTERINE RUPTURE].
Topics: Delivery, Obstetric; Female; Humans; Labor, Obstetric; Obstetric Labor Complications; Oxytocics; Oxy | 1964 |
[The effect of cardioazol-spartein on labor pains recorded in the tocogram].
Topics: Adolescent; Female; Humans; Labor Pain; Labor, Obstetric; Pentylenetetrazole; Pregnancy; Sparteine; | 1954 |
[Intravenous ecbolic for accelerated labor].
Topics: Female; Humans; Labor, Obstetric; Pentylenetetrazole; Pregnancy; Work | 1951 |
[Acceleration of delivery with intravenous orasthin-cardiazol].
Topics: Acceleration; Delivery, Obstetric; Female; Humans; Labor, Obstetric; Pentylenetetrazole; Pregnancy; | 1951 |
[Avoidance of forceps by intravenous orasthin-cardiazol injection (Baltzer's forced delivery)].
Topics: Female; Hormones; Humans; Labor, Induced; Labor, Obstetric; Pentylenetetrazole; Pituitary Gland; Pit | 1951 |
Morphological and functional changes of blood-brain barrier in kindled rats with cortical dysplasia.
Topics: Animals; Blood-Brain Barrier; Capillary Permeability; Disease Models, Animal; Female; Glial Fibrilla | 2008 |
Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy.
Topics: Animals; Anticonvulsants; Electroshock; Epilepsy; Fatty Acids, Monounsaturated; Fatty Acids, Unsatur | 1984 |
Kinetics of drug action in disease states III: Effect of pregnancy on the relationship between phenytoin concentration and antiseizure activity in rats.
Topics: Electroshock; Female; Humans; Kinetics; Pentylenetetrazole; Phenytoin; Pregnancy; Pregnancy Complica | 1984 |
Alteration of convulsive threshold and sensitivity to CNS acting drugs in sedative-hypnotics-experienced rat offspring.
Topics: Animals; Animals, Newborn; Animals, Suckling; Ethanol; Female; Humans; Hypnotics and Sedatives; Moto | 1982 |
Developmental, behavioral, and pharmacological characteristics of rat offspring from mothers receiving ethanol during gestation or lactation.
Topics: Alcohol Drinking; Animals; Behavior, Animal; Body Weight; Female; Lactation; Male; Maternal Behavior | 1980 |
Prenatal cocaine: seizure susceptibility in rat offspring.
Topics: Age Factors; Animals; Animals, Newborn; Bicuculline; Body Weight; Brain; Cocaine; Female; Humans; In | 1995 |
Prenatal lorazepam exposure: 4. Persistent alterations in pentylenetetrazole-induced seizure threshold and GABA-dependent chloride uptake after prenatal lorazepam exposure.
Topics: Animals; Brain Chemistry; Chlorides; Chlorine; Female; gamma-Aminobutyric Acid; Lorazepam; Mice; Mus | 1995 |
Effect of fetal hypoxia on seizure susceptibility in rats.
Topics: Animals; Electrocardiography; Female; Fetal Hypoxia; Male; Pentylenetetrazole; Pregnancy; Prenatal E | 1995 |
Disruption of GABA-dependent chloride flux by cyclodienes and hexachlorocyclohexanes in primary cultures of cortical neurons.
Topics: Animals; Calcium; Cells, Cultured; Cerebral Cortex; Chlorides; Endosulfan; Female; gamma-Aminobutyri | 1994 |
Prenatal cocaine exposure increases susceptibility to drug-induced seizures. c-fos induction and brain cocaine levels.
Topics: Animals; Brain; Cocaine; Disease Susceptibility; Female; Gene Expression Regulation; Male; Pentylene | 1998 |
Enhancement of pentylenetetrazol-induced kindling in mice treated neonatally with monosodium glutamate.
Topics: Animals; Animals, Newborn; Drug Synergism; Female; Kindling, Neurologic; Male; Mice; Pentylenetetraz | 1998 |
Spatiotemporal analysis of Fos expression associated with cocaine- and PTZ-induced seizures in prenatally cocaine-treated rats.
Topics: Animals; Brain; Cell Count; Cocaine; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitat | 2001 |
[Characteristics of the function of the higher portions of the central nervous system of rats subjected to acute hypoxia in the antenatal period].
Topics: Acute Disease; Altitude; Animals; Atmosphere Exposure Chambers; Central Nervous System; Conditioning | 1976 |
On the development of alternative antiepileptic drugs. Lack of enantioselectivity of the anticonvulsant activity, in contrast to teratogenicity, of 2-n-propyl-4-pentenoic acid and 2-n-propyl-4-pentynoic acid, analogues of the anticonvulsant drug valproic
Topics: Animals; Anticonvulsants; Drug Design; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Femal | 1991 |
Prenatal chlordiazepoxide effects on metrazol seizures and benzodiazepine receptors density in adult albino rats.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Chlordiazepoxide; Drug Resistance; Female; Flunitrazepa | 1985 |
Behavioural similarities between mother rats and benzodiazepine-treated non-maternal animals.
Topics: Aggression; Animals; Benzodiazepines; Caffeine; Carbolines; Fear; Feeding Behavior; Female; Humans; | 1985 |
Kinetics of drug action in disease states. XV: Effect of pregnancy on the convulsive activity of pentylenetetrazol in rats.
Topics: Animals; Brain; Female; Kinetics; Male; Pentylenetetrazole; Pregnancy; Pregnancy, Animal; Rats; Rats | 1985 |
Circannual rhythm of free fatty acids and diacylglycerols in 5-day-old rat cerebrum during pentylenetetrazol-induced convulsions.
Topics: Animals; Brain; Brain Chemistry; Diglycerides; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; | 1985 |
Ontogenesis of paroxysmal cortical activity in foetal sheep.
Topics: Animals; Cerebral Cortex; Electric Stimulation; Electroencephalography; Female; Fetus; Pentylenetetr | 1966 |
Effects of certain psychotropic drugs on immunologic pregnancy tests.
Topics: Chlorpromazine; Chlorprothixene; Chorionic Gonadotropin; False Positive Reactions; Female; Fluphenaz | 1969 |
Hypnotic and hypothermic effect of pregnant mare urine extracts in the rat.
Topics: Amphetamine; Animals; Body Temperature; Female; Horses; Hypnosis; Hypothermia, Induced; Injections, | 1968 |