pentylenetetrazole has been researched along with Neural Tube Defects in 8 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Neural Tube Defects: Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In mice, M-TMCD afforded protection against maximal electroshock (MES)-induced, pentylenetetrazol (Metrazol)-induced, and bicuculline-induced seizures, as well as against 6-Hz "psychomotor" seizures and sound-induced seizures with ED50 values of 99, 39, 81, 51, and 10 mg/kg, respectively." | 3.71 | Anticonvulsant profile and teratogenicity of N-methyl-tetramethylcyclopropyl carboxamide: a new antiepileptic drug. ( Barton, ME; Bennett, GD; Bialer, M; Finnell, RH; Isoherranen, N; White, HS; Wilcox, KS; Woodhead, JH; Yagen, B, 2002) |
| " Consequently, the aim of the current study was to comparatively evaluate the pharmacokinetic (PK) and pharmacodynamic (PD anticonvulsant activity) profile of EMC and IPC individual enantiomers." | 2.79 | Enantioselective pharmacodynamic and pharmacokinetic analysis of two chiral CNS-active carbamate derivatives of valproic acid. ( Bialer, M; Finnell, RH; Mawasi, H; McDonough, JH; Shekh-Ahmad, T; Wlodarczyk, BJ; Yavin, E, 2014) |
| " VCU was mainly eliminated by metabolism with a half-life of 2 h." | 1.36 | Evaluation of stereoselective anticonvulsant, teratogenic, and pharmacokinetic profile of valnoctylurea (capuride): a chiral stereoisomer of valproic acid urea derivative. ( Bialer, M; Finnell, RH; Schurig, V; Shimshoni, JA; Wlodarczyk, B; Yagen, B, 2010) |
| " Comparative pharmacokinetic analysis showed that α-Cl-TMCD is less susceptible to liver first-pass effect than α-F-TMCD because of lower total (metabolic) clearance and liver extraction ratio." | 1.36 | Comparative pharmacodynamic and pharmacokinetic analysis of two anticonvulsant halo derivatives of 2,2,3,3-tetramethylcyclopropanecarboxamide, an amide of a cyclic analog of valproic acid. ( Bialer, M; Finnell, RH; Hen, N; Kaufmann, D; Pessah, N; Wlodarczyk, B; Yagen, B, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shekh-Ahmad, T | 1 |
| Mawasi, H | 1 |
| McDonough, JH | 1 |
| Finnell, RH | 7 |
| Wlodarczyk, BJ | 1 |
| Yavin, E | 1 |
| Bialer, M | 8 |
| Shimshoni, JA | 4 |
| Yagen, B | 7 |
| Wlodarczyk, B | 5 |
| Schurig, V | 1 |
| Okada, A | 1 |
| Noyori, H | 1 |
| Fujiwara, M | 1 |
| Hen, N | 3 |
| Pessah, N | 3 |
| Kaufmann, D | 1 |
| Isoherranen, N | 1 |
| White, HS | 1 |
| Woodhead, JH | 1 |
| Bennett, GD | 1 |
| Wilcox, KS | 1 |
| Barton, ME | 1 |
1 trial available for pentylenetetrazole and Neural Tube Defects
| Article | Year |
|---|---|
Enantioselective pharmacodynamic and pharmacokinetic analysis of two chiral CNS-active carbamate derivatives of valproic acid.
Topics: Animals; Anticonvulsants; Area Under Curve; Carbamates; Central Nervous System; Convulsants; Disease | 2014 |
7 other studies available for pentylenetetrazole and Neural Tube Defects
| Article | Year |
|---|---|
Evaluation of stereoselective anticonvulsant, teratogenic, and pharmacokinetic profile of valnoctylurea (capuride): a chiral stereoisomer of valproic acid urea derivative.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug | 2010 |
Anticonvulsant profile and teratogenic evaluation of potent new analogues of a valproic acid urea derivative in NMRI mice.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Bone and Bones; Deep Sedation; Differential T | 2009 |
Syntheses and evaluation of anticonvulsant profile and teratogenicity of novel amide derivatives of branched aliphatic carboxylic acids with 4-aminobenzensulfonamide.
Topics: Anilides; Animals; Anticonvulsants; Convulsants; Electroshock; Mice; Neural Tube Defects; Pentylenet | 2010 |
Comparative pharmacodynamic and pharmacokinetic analysis of two anticonvulsant halo derivatives of 2,2,3,3-tetramethylcyclopropanecarboxamide, an amide of a cyclic analog of valproic acid.
Topics: Abnormalities, Drug-Induced; Amides; Analgesics; Animals; Anticonvulsants; Cyclopropanes; Disease Mo | 2010 |
Design and pharmacological activity of glycinamide and N-methoxy amide derivatives of analogs and constitutional isomers of valproic acid.
Topics: Amides; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroshock; Female; Isomeri | 2011 |
Anticonvulsant profile and teratogenicity of 3,3-dimethylbutanoylurea: a potential for a second generation drug to valproic acid.
Topics: Animals; Anticonvulsants; Behavior, Animal; Electrodes, Implanted; Half-Life; Hippocampus; Kindling, | 2008 |
Anticonvulsant profile and teratogenicity of N-methyl-tetramethylcyclopropyl carboxamide: a new antiepileptic drug.
Topics: Acoustic Stimulation; Administration, Oral; Amides; Animals; Anticonvulsants; Behavior, Animal; Bicu | 2002 |