pentylenetetrazole has been researched along with Nervous System Diseases in 12 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Nervous System Diseases: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The anticonvulsant activity of all of the synthesized compounds was evaluated against maximal electrical shock (MES) and subcutaneous pentylenetetrazole (scPTZ) induced seizures." | 3.76 | Synthesis and anticonvulsant activity of 4-oxo and 4-thioxo-8-bromobenzopyran derivatives. ( Abd El-Latif, HA; Abu Yossef, HA; Hassan, GS; Ragab, FA; Yahya, TA, 2010) |
| "Phenytoin (DPH) was delivered to the brain by a dihydropyridine in equilibrium pyridinium salt redox system, which was evaluated for anticonvulsant activity." | 1.28 | Improved anticonvulsant activity of phenytoin by a redox brain delivery system. III: Brain uptake and pharmacological effects. ( Bodor, NS; Murakami, T; Nath, C; Pop, E; Shek, E, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (41.67) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Almeida, AAC | 1 |
| Ferreira, JRO | 1 |
| de Carvalho, RBF | 1 |
| Rizzo, MDS | 1 |
| Lopes, LDS | 1 |
| Dittz, D | 1 |
| Castro E Souza, JM | 1 |
| Ferreira, PMP | 1 |
| Al-Harrasi, A | 1 |
| Khan, A | 1 |
| Rehman, NU | 1 |
| Al-Shidhani, S | 1 |
| Karim, N | 1 |
| Khan, I | 1 |
| Halim, SA | 1 |
| Al-Rawahi, A | 1 |
| Hussain, J | 1 |
| Csuk, R | 1 |
| Kamal, M | 1 |
| Shakya, AK | 1 |
| Ahsan, MJ | 1 |
| Jawaid, T | 1 |
| Ragab, FA | 1 |
| Hassan, GS | 1 |
| Abu Yossef, HA | 1 |
| Yahya, TA | 1 |
| Abd El-Latif, HA | 1 |
| BARTSCHI-ROCHAIX, W | 1 |
| BARTSCHI-ROCHAIX, F | 1 |
| FABING, HD | 1 |
| Ozkanli, F | 1 |
| Güney, A | 1 |
| Caliş, U | 1 |
| Uzbay, T | 1 |
| Elmazar, MM | 1 |
| Hauck, RS | 1 |
| Nau, H | 1 |
| Dimmock, JR | 1 |
| Patil, SA | 1 |
| Shyam, K | 1 |
| Shek, E | 1 |
| Murakami, T | 1 |
| Nath, C | 1 |
| Pop, E | 1 |
| Bodor, NS | 1 |
| Prabhu, VG | 1 |
| Oester, YT | 1 |
| Millichap, JG | 1 |
| Pitchford, GL | 1 |
| Millichap, MG | 1 |
12 other studies available for pentylenetetrazole and Nervous System Diseases
| Article | Year |
|---|---|
Non-clinical toxicity of (+)-limonene epoxide and its physio-pharmacological properties on neurological disorders.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Artemia; Dose-Response Relationship, Drug; Epoxy Co | 2020 |
Evidence for the involvement of a GABAergic mechanism in the effectiveness of natural and synthetically modified incensole derivatives in neuropharmacological disorders: A computational and pharmacological approach.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Biological Products; Diterpenes; Maze Learning; Mi | 2019 |
Synthesis, anticonvulsant and neurotoxicity evaluation of some newer N-(2-benzoylbenzofuran-3-yl)-3-(substituted)-propanamide analogs.
Topics: Animals; Anticonvulsants; Benzofurans; Convulsants; Drug Design; Electroshock; Indicators and Reagen | 2013 |
Synthesis and anticonvulsant activity of 4-oxo and 4-thioxo-8-bromobenzopyran derivatives.
Topics: Animals; Anticonvulsants; Benzopyrans; Electroshock; Indicators and Reagents; Lethal Dose 50; Male; | 2010 |
[The combined cardiazol-barbiturate activation of EEG in neurological diagnosis (Triplex activation)].
Topics: Barbiturates; Electroencephalography; Humans; Nervous System Diseases; Pentylenetetrazole | 1955 |
Newer therapeutic weapons against disorders of the nervous system.
Topics: Electroencephalography; Humans; Nervous System Diseases; Niacin; Nicotinic Acids; Pentylenetetrazole | 1958 |
Synthesis and anticonvulsant activity of some new dioxolane derivatives.
Topics: Animals; Anticonvulsants; Dioxolanes; Drug Evaluation, Preclinical; Electric Stimulation; Electrosho | 2003 |
Anticonvulsant and neurotoxic activities of twelve analogues of valproic acid.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Nervou | 1993 |
Evaluation of some Mannich bases of 1-aryl-1-ethanones and related ketones for anticonvulsant activities.
Topics: Animals; Anticonvulsants; Electroshock; Mannich Bases; Mice; Nervous System Diseases; Pentylenetetra | 1991 |
Improved anticonvulsant activity of phenytoin by a redox brain delivery system. III: Brain uptake and pharmacological effects.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Chemical Phenomena; Chemistry, Physical; Chromato | 1989 |
Neuromuscular functions of mature mice following neonatal monosodium glutamate.
Topics: Animals; Animals, Newborn; Body Weight; Crowding; Dextroamphetamine; Female; Food Additives; Glutama | 1971 |
Anticonvulsant activity of antiparkinsonism agents.
Topics: Animals; Anticonvulsants; Child; Child, Preschool; Electroshock; Female; Glaucoma; Humans; Infant; M | 1968 |