pentylenetetrazole has been researched along with Nerve Degeneration in 22 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we investigate the anti-convulsant and neuroprotective effects of thymoquinone (TQ) and vitamin C against pentylenetetrazole (PTZ)-induced generalized seizures." | 7.81 | Thymoquinone and vitamin C attenuates pentylenetetrazole-induced seizures via activation of GABAB1 receptor in adult rats cortex and hippocampus. ( Badshah, H; Kim, MO; Lee, HY; Naseer, MI; Ullah, I, 2015) |
| "Behavioral scoring was used to access seizure." | 5.43 | Anticonvulsant and neuroprotective effects of apelin-13 on pentylenetetrazole-induced seizures in male rats. ( Asadi-Shekaari, M; Esmaeili-Mahani, S; Kalantaripour, TP; Pasban-Aliabadi, H; Sheibani, V, 2016) |
| "Pentylenetetrazol (PTZ)-induced chronic kindling model and lithium-pilocarpine-induced status epilepticus (SE) model were used in this study." | 3.81 | Degeneration and regeneration of GABAergic interneurons in the dentate gyrus of adult mice in experimental models of epilepsy. ( Jiang, W; Wang, Y; Wei, D; Wu, C; Wu, SX; Yang, F, 2015) |
| " In this study, we investigate the anti-convulsant and neuroprotective effects of thymoquinone (TQ) and vitamin C against pentylenetetrazole (PTZ)-induced generalized seizures." | 3.81 | Thymoquinone and vitamin C attenuates pentylenetetrazole-induced seizures via activation of GABAB1 receptor in adult rats cortex and hippocampus. ( Badshah, H; Kim, MO; Lee, HY; Naseer, MI; Ullah, I, 2015) |
| " The available experimental evidence and the safety of vit-C in pregnancy suggest the experimental use of ascorbic acid as a new and effective protective agent ethanol and PTZ-induced apoptotic neurodegeneration." | 3.77 | Vitamin C protects against ethanol and PTZ-induced apoptotic neurodegeneration in prenatal rat hippocampal neurons. ( Kim, MO; Koh, PO; Lee, HY; Naseer, MI; Park, MS; Ullah, I; Ullah, N, 2011) |
| "Structural changes in neurons and oxidative stress in hippocampus were studied in rats "tolerant" (TR) and susceptible (SR) to tonic and clonic seizures in pentylenetetrazole (PTZ) kindling." | 3.73 | [Pentylenetetrazole kindling in rats: whether neurodegeneration is associated with manifestations of seizure activity?]. ( Guliaeva, NV; Iakovleva, AA; Pavlova, TV; Stepanichev, MIu, 2005) |
| "Behavioral scoring was used to access seizure." | 1.43 | Anticonvulsant and neuroprotective effects of apelin-13 on pentylenetetrazole-induced seizures in male rats. ( Asadi-Shekaari, M; Esmaeili-Mahani, S; Kalantaripour, TP; Pasban-Aliabadi, H; Sheibani, V, 2016) |
| "Sulforaphane was anticonvulsant in two acute mouse models of epilepsy and protected mice against pilocarpine-induced status epilepticus (SE)." | 1.42 | Sulforaphane is anticonvulsant and improves mitochondrial function. ( Borges, K; Carrasco-Pozo, C; Tan, KN, 2015) |
| "Epilepsy is a prominent sign of neurological dysfunction in children with various fetal and maternal deficiencies." | 1.35 | Maternal epileptic seizure induced by pentylenetetrazol: apoptotic neurodegeneration and decreased GABAB1 receptor expression in prenatal rat brain. ( Kim, MO; Naseer, MI; Shupeng, L, 2009) |
| "Thus, rats " tolerant" to developing convulsions show signs of oxidative stress and neurodegenerative changes in the hippocampus." | 1.33 | Pentylenetetrazol kindling in rats: Is neurodegeneration associated with manifestations of convulsive activity? ( Gulyaeva, NV; Pavlova, TV; Stepanichev, MY; Yakovlev, AA, 2006) |
| "After pentylenetetrazol-induced seizures: (i) S100B values increased from 10 to 30 min, returning to control levels at 24 h; NSE levels presented a biphasic increase: an increase at 10 to 30 min returning to control levels, and again at 240 min followed by a decline at 24 h; (ii) nucleotidase activities increased from 10 min, returning to control levels at 240 min; (iii) guanosine and inosine levels increased exclusively after 30 min." | 1.32 | Biochemical brain markers and purinergic parameters in rat CSF after seizure induced by pentylenetetrazol. ( Casali, EA; Lara, DR; Leke, R; Oses, JP; Portela, LV; Sarkis, JJ; Schmidt, AP; Souza, DO; Wofchuk, S, 2004) |
| "All rats given PTZ developed recurrent seizures." | 1.31 | Maternal deprivation stress exacerbates cognitive deficits in immature rats with recurrent seizures. ( Holmes, GL; Huang, LT; Hung, PL; Lai, MC; Liou, CW; Wang, CL; Wang, TJ; Yang, CH; Yang, SN, 2002) |
| "Thirty seconds after VNS onset, seizures were induced by pentylenetetrazol (PTZ), and seizure severity was measured." | 1.31 | Destruction of peripheral C-fibers does not alter subsequent vagus nerve stimulation-induced seizure suppression in rats. ( Handforth, A; Krahl, SE; Senanayake, SS, 2001) |
| "Transient systemic hypercapnic anoxia (22-sec exposure to 100% CO2 gas), before treatment with NMDA did not significantly reduce the NMDA-induced behavior." | 1.28 | Cerebral ischemia decreases the behavioral effects and mortality rate elicited by activation of NMDA receptors in mice. ( Himori, N; Martin, JR; Moreau, JL, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 3 (13.64) | 18.2507 |
| 2000's | 11 (50.00) | 29.6817 |
| 2010's | 7 (31.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wei, D | 1 |
| Yang, F | 2 |
| Wang, Y | 1 |
| Wu, C | 1 |
| Wu, SX | 1 |
| Jiang, W | 1 |
| Ullah, I | 3 |
| Badshah, H | 1 |
| Naseer, MI | 4 |
| Lee, HY | 3 |
| Kim, MO | 4 |
| Carrasco-Pozo, C | 1 |
| Tan, KN | 1 |
| Borges, K | 1 |
| Kalantaripour, TP | 1 |
| Esmaeili-Mahani, S | 1 |
| Sheibani, V | 1 |
| Asadi-Shekaari, M | 1 |
| Pasban-Aliabadi, H | 1 |
| Koeller, HB | 1 |
| Ross, ME | 1 |
| Glickstein, SB | 1 |
| Shupeng, L | 1 |
| Pereno, G | 1 |
| Beltramino, C | 1 |
| Ullah, N | 2 |
| Koh, PO | 1 |
| Park, MS | 1 |
| Cheon, EW | 1 |
| Chung, J | 1 |
| Huang, LT | 1 |
| Holmes, GL | 1 |
| Lai, MC | 1 |
| Hung, PL | 1 |
| Wang, CL | 1 |
| Wang, TJ | 1 |
| Yang, CH | 1 |
| Liou, CW | 1 |
| Yang, SN | 1 |
| Oses, JP | 1 |
| Leke, R | 1 |
| Portela, LV | 1 |
| Lara, DR | 1 |
| Schmidt, AP | 1 |
| Casali, EA | 1 |
| Wofchuk, S | 1 |
| Souza, DO | 1 |
| Sarkis, JJ | 1 |
| Ahmed, MM | 1 |
| Arif, M | 1 |
| Chikuma, T | 1 |
| Kato, T | 1 |
| Pavlova, TV | 2 |
| Iakovleva, AA | 1 |
| Stepanichev, MIu | 1 |
| Guliaeva, NV | 1 |
| Park, JH | 1 |
| Cho, H | 1 |
| Kim, H | 1 |
| Kim, K | 1 |
| Yakovlev, AA | 1 |
| Stepanichev, MY | 1 |
| Gulyaeva, NV | 1 |
| Jandová, K | 1 |
| Riljak, V | 1 |
| Pokorný, J | 1 |
| Langmeier, M | 1 |
| de Oliveira, PA | 1 |
| Lino, FL | 1 |
| Cappelari, SE | 1 |
| da Silva Brum, LF | 1 |
| Picada, JN | 1 |
| Pereira, P | 1 |
| Schulze-Bonhage, A | 1 |
| Wiemann, M | 1 |
| Altrup, U | 1 |
| Wittkowski, W | 1 |
| Speckmann, EJ | 1 |
| Krahl, SE | 1 |
| Senanayake, SS | 1 |
| Handforth, A | 1 |
| Li, X | 1 |
| Song, L | 1 |
| Kolasa, K | 1 |
| Jope, RS | 1 |
| Himori, N | 1 |
| Moreau, JL | 1 |
| Martin, JR | 1 |
| Kovacs, DA | 1 |
| Zoll, JG | 1 |
22 other studies available for pentylenetetrazole and Nerve Degeneration
| Article | Year |
|---|---|
Degeneration and regeneration of GABAergic interneurons in the dentate gyrus of adult mice in experimental models of epilepsy.
Topics: Animals; Chronic Disease; Dentate Gyrus; Epilepsy; GABAergic Neurons; Glutamate Decarboxylase; Green | 2015 |
Thymoquinone and vitamin C attenuates pentylenetetrazole-induced seizures via activation of GABAB1 receptor in adult rats cortex and hippocampus.
Topics: Animals; Anticonvulsants; Antioxidants; Ascorbic Acid; Benzoquinones; Calcium-Calmodulin-Dependent P | 2015 |
Sulforaphane is anticonvulsant and improves mitochondrial function.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electron Transport Complex I; Electro | 2015 |
Anticonvulsant and neuroprotective effects of apelin-13 on pentylenetetrazole-induced seizures in male rats.
Topics: Animals; Anticonvulsants; Apelin Receptors; Apoptosis; Astrocytes; Brain; Disease Models, Animal; Gl | 2016 |
Cyclin D1 in excitatory neurons of the adult brain enhances kainate-induced neurotoxicity.
Topics: Adult; Animals; Apoptosis; Convulsants; Cyclin D1; Disease Models, Animal; Epilepsy; Female; Hippoca | 2008 |
Maternal epileptic seizure induced by pentylenetetrazol: apoptotic neurodegeneration and decreased GABAB1 receptor expression in prenatal rat brain.
Topics: Animals; Apoptosis; Brain; Caspase 3; Cyclic AMP-Dependent Protein Kinases; Cytochromes c; Electroen | 2009 |
[Understanding the pathophysiology of epilepsy in an animal model: pentylenetetrazole induces activation but not death of neurons of the medial extended amygdala].
Topics: Amygdala; Animals; Convulsants; Disease Models, Animal; Epilepsy; Humans; Male; Nerve Degeneration; | 2010 |
Vitamin C protects against ethanol and PTZ-induced apoptotic neurodegeneration in prenatal rat hippocampal neurons.
Topics: Animals; Apoptosis; Ascorbic Acid; Blotting, Western; Cells, Cultured; Central Nervous System Depres | 2011 |
Neuroprotective effect of vitamin C against PTZ induced apoptotic neurodegeneration in adult rat brain.
Topics: Animals; Apoptosis; Ascorbic Acid; Brain; Caspase 3; Disease Models, Animal; Epilepsy; Male; Nerve D | 2011 |
Maternal deprivation stress exacerbates cognitive deficits in immature rats with recurrent seizures.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Cognition Disorders; Cyclic AMP Response Element | 2002 |
Biochemical brain markers and purinergic parameters in rat CSF after seizure induced by pentylenetetrazol.
Topics: Adenosine; Adenosine Diphosphate; Animals; Antigens, CD; Apyrase; Biomarkers; Brain; Convulsants; Di | 2004 |
Pentylenetetrazol-induced seizures affect the levels of prolyl oligopeptidase, thimet oligopeptidase and glial proteins in rat brain regions, and attenuation by MK-801 pretreatment.
Topics: Animals; Brain; CD11b Antigen; Cerebral Cortex; Convulsants; Disease Models, Animal; Dizocilpine Mal | 2005 |
[Pentylenetetrazole kindling in rats: whether neurodegeneration is associated with manifestations of seizure activity?].
Topics: Animals; Convulsants; Hippocampus; Kindling, Neurologic; Male; Nerve Degeneration; Oxidative Stress; | 2005 |
Repeated brief epileptic seizures by pentylenetetrazole cause neurodegeneration and promote neurogenesis in discrete brain regions of freely moving adult rats.
Topics: Animals; Brain; Cell Proliferation; Convulsants; Disease Models, Animal; Epilepsy; Female; GABA Anta | 2006 |
Pentylenetetrazol kindling in rats: Is neurodegeneration associated with manifestations of convulsive activity?
Topics: Animals; Cell Count; Convulsants; Hippocampus; Kindling, Neurologic; Male; Nerve Degeneration; Neuro | 2006 |
Pentylentetrazol associated changes of hippocampal neurons in immature rats.
Topics: Animals; Convulsants; Dentate Gyrus; GABA Antagonists; Hippocampus; Histocytochemistry; Male; NADPH | 2007 |
Effects of gamma-decanolactone on seizures induced by PTZ-kindling in mice.
Topics: Animals; Anticonvulsants; Brain; Comet Assay; Convulsants; Disease Models, Animal; DNA Damage; Dose- | 2008 |
Epileptic discharges induced by pentylenetetrazol: ultrastructural alterations in identified neurons and glial cells (Helix pomatia).
Topics: Animals; Cell Nucleolus; Cell Size; Cytoplasmic Granules; Epilepsy; Ganglia, Invertebrate; Helix, Sn | 1995 |
Destruction of peripheral C-fibers does not alter subsequent vagus nerve stimulation-induced seizure suppression in rats.
Topics: Animals; Animals, Newborn; Capsaicin; Electric Stimulation Therapy; Humans; Nerve Degeneration; Nerv | 2001 |
Adrenalectomy potentiates immediate early gene expression in rat brain.
Topics: Adrenalectomy; Animals; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Electrophoresis, A | 1992 |
Cerebral ischemia decreases the behavioral effects and mortality rate elicited by activation of NMDA receptors in mice.
Topics: Animals; Behavior, Animal; Carbon Dioxide; Dizocilpine Maleate; Female; Hypoxia; Injections, Intrave | 1991 |
Seizure inhibition by median raphe nucleus stimulation in rat.
Topics: Amygdala; Animals; Disease Models, Animal; Electric Stimulation; Electroencephalography; Epilepsy; E | 1974 |