pentylenetetrazole has been researched along with Myoclonic Jerk in 47 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pentylenetetrazole (PTZ) was administered to induce seizures in a total number of 48 Sprague-Dawley rats." | 4.31 | N-acetyl cysteine: A new look at its effect on PTZ-induced convulsions. ( Azak Pazarlar, B; Bilister Egilmez, C; Erbas, O; Erdogan, MA, 2023) |
| "The effect of oxaprozin (OXP) on an experimental model of seizures in rats was investigated in this study." | 4.12 | Anticonvulsant activity of oxaprozin in a rat model of pentylenetetrazole-induced seizure by targeting oxidative stress and SIRT1/PGC1α signaling. ( Bananej, M; Khatami, P; Khosravi, M; Mirazi, N, 2022) |
| "We aimed to explore the effects of neuropeptides ghrelin, obestatin, and vasoactive intestinal peptide (VIP) on seizures and plasma concentrations of neuroinflammation biomarkers including calcitonin gene-related peptide (CGRP), substance-P (SP), and interleukin-1 beta (IL-1β) in pentylenetetrazol-induced seizures in rats." | 3.91 | Modulatory effects of neuropeptides on pentylenetetrazol-induced epileptic seizures and neuroinflammation in rats. ( Gunes, H; Kilinc, E, 2019) |
| "To investigate the modulatory effects of morphine on the susceptibility to pentylenetetrazole-induced seizures, and the involvement of endogenous histamine in this process." | 3.74 | [Involvement of endogenous histamine in modulatory effect of morphine on seizure susceptibility in mice]. ( Chen, Z; Jin, CL; Wu, DC; Zhu, YY; Zhu-Ge, ZB, 2007) |
| "This work evaluates the seizure susceptibility of nai;ve female Wistar Audiogenic rats (WARs), a genetic model of reflex epilepsy in which seizures are induced by high-intensity sound stimulation (120 dB SPL), to other pro-convulsive stimuli: transauricular electroshock (ES), pentylenetetrazole (PTZ) and pilocarpine (PILO)." | 3.72 | Assessment of the seizure susceptibility of Wistar Audiogenic rat to electroshock, pentyleneterazole and pilocarpine. ( Doretto, MC; Magalhães, LH; Moraes, MF; Scarlatelli-Lima, AV, 2003) |
| "The development of tolerance to the protective effects of diazepam (4 mg/kg) against seizures induced by pentylenetetrazole (PTZ) were studied in 3 strains of mice." | 3.66 | Strain differences in mice in the development of tolerance to the anti-pentylenetetrazole effects of diazepam. ( File, SE, 1983) |
| "Liraglutide is a glucagon-like peptide-1 (GLP-1) analogue that is used to treat type-2 diabetes mellitus." | 1.91 | The Anti-Seizure Effect of Liraglutide on Ptz-Induced Convulsions Through its Anti-Oxidant and Anti-Inflammatory Properties. ( Erbas, O; Erdogan, A; Erdogan, MA, 2023) |
| "Epilepsy is a disease which affects between 1 and 2% of the population, and a large proportion of these people do not react to currently available anticonvulsant medications, indicating the need for further research into novel pharmacological therapies." | 1.91 | Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions. ( Erbas, O; Erdogan, A; Erdogan, MA; Gurgul, S, 2023) |
| "First myoclonic jerks decreased while seizure severity and total spike count increased in the PTZ group." | 1.62 | Vortioxetine suppresses epileptiform activity and cognition deficits in a chronic PTZ-induced kindling rat model. ( Taskiran, M; Unal, G, 2021) |
| "Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used as an anti-inflammatory, anti-pyretic, and analgesic." | 1.56 | Beneficial Effects of Ibuprofen on Pentylenetetrazol-induced Convulsion. ( Albayrak, Y; Atasoy, Ö; Beyazyüz, M; Durankuş, F; Erbaş, O; Şenkal, E; Sünnetçi, E, 2020) |
| "Ursolic acid (UA) is a plant derived compound which is also a component of the standard human diet." | 1.48 | Assessment of the Anticonvulsant Potency of Ursolic Acid in Seizure Threshold Tests in Mice. ( Nieoczym, D; Socała, K; Wlaź, P, 2018) |
| "Many drugs have been associated with seizures as a side effect." | 1.43 | Positive effects of ceftriaxone on pentylenetetrazol-induced convulsion model in rats. ( Çavuşoğlu, T; Erbas, O; Özkeşkek, K; Solmaz, V; Tümer, MK; Uyanikgil, Y, 2016) |
| "PTZ) seizure test, the maximal electroshock seizure threshold (MEST) test and the 6 Hz seizure test were used in the present study." | 1.43 | SB 334867, a selective orexin receptor type 1 antagonist, elevates seizure threshold in mice. ( Socała, K; Szuster-Ciesielska, A; Wlaź, P, 2016) |
| "After repeated treatment the PTZ seizure threshold was not different between the two drugs, while differences in sedation became larger than after the acute treatment." | 1.35 | Effects of acute and repeated zolpidem treatment on pentylenetetrazole-induced seizure threshold and on locomotor activity: comparison with diazepam. ( Pericić, D; Vlainić, J, 2009) |
| "Myoclonic jerks were elicited by PTZ in all age groups studied." | 1.27 | Correlation between electrocorticographic and motor phenomena induced by pentamethylenetetrazol during ontogenesis in rats. ( Mares, P; Schickerová, R; Trojan, S, 1984) |
| "Tonic seizure was seen at birth, myoclonic jerks at 2 weeks of age, myoclonic seizure and catalepsy at 3 weeks of age." | 1.25 | Maturation of convulsogenic activity induced by leptazol in the albino rat. ( de Casrilevitz, M; Engelhardt, E; Esbérard, CA, 1971) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (61.70) | 18.7374 |
| 1990's | 1 (2.13) | 18.2507 |
| 2000's | 4 (8.51) | 29.6817 |
| 2010's | 7 (14.89) | 24.3611 |
| 2020's | 6 (12.77) | 2.80 |
| Authors | Studies |
|---|---|
| Taskiran, M | 1 |
| Unal, G | 1 |
| Khatami, P | 1 |
| Mirazi, N | 1 |
| Khosravi, M | 1 |
| Bananej, M | 1 |
| Erdogan, MA | 4 |
| Erdogan, A | 3 |
| Erbas, O | 8 |
| Gurgul, S | 2 |
| Bilister Egilmez, C | 1 |
| Azak Pazarlar, B | 1 |
| Kilinc, E | 1 |
| Gunes, H | 1 |
| Durankuş, F | 1 |
| Şenkal, E | 1 |
| Sünnetçi, E | 1 |
| Albayrak, Y | 1 |
| Beyazyüz, M | 1 |
| Atasoy, Ö | 1 |
| Amin, F | 1 |
| Dar, AH | 1 |
| Osama, K | 1 |
| Khan, F | 1 |
| Mitha, R | 1 |
| Tharwani, A | 1 |
| Haider, G | 1 |
| Chand, P | 1 |
| Arain, FM | 1 |
| Nieoczym, D | 1 |
| Socała, K | 2 |
| Wlaź, P | 2 |
| Aksoy, D | 2 |
| Solmaz, V | 3 |
| Taşkıran, D | 1 |
| Uyanikgil, Y | 1 |
| Özkeşkek, K | 1 |
| Çavuşoğlu, T | 1 |
| Tümer, MK | 1 |
| Szuster-Ciesielska, A | 1 |
| Vlainić, J | 1 |
| Pericić, D | 1 |
| Scarlatelli-Lima, AV | 1 |
| Magalhães, LH | 1 |
| Doretto, MC | 1 |
| Moraes, MF | 1 |
| Tchekalarova, J | 1 |
| Georgiev, V | 1 |
| Zhu-Ge, ZB | 1 |
| Zhu, YY | 1 |
| Wu, DC | 1 |
| Jin, CL | 1 |
| Chen, Z | 1 |
| Roger, J | 1 |
| Gastaut, H | 1 |
| Boudouresques, J | 1 |
| Toga, M | 1 |
| Dubois, D | 1 |
| Lob, H | 1 |
| Portig, J | 1 |
| Stein, K | 1 |
| File, SE | 2 |
| Simmonds, MA | 1 |
| Schickerová, R | 1 |
| Mares, P | 1 |
| Trojan, S | 1 |
| McCaughran, JA | 1 |
| Schechter, N | 1 |
| Alexander, GJ | 3 |
| Chatterjie, N | 2 |
| Kopeloff, LM | 3 |
| Alexander, RB | 2 |
| Löscher, W | 1 |
| Hönack, D | 1 |
| Arushanian, EB | 1 |
| McMillen, BA | 1 |
| Isaac, L | 1 |
| Avakian, RM | 1 |
| Escorihuela, RM | 1 |
| Boix, F | 1 |
| Corda, MG | 1 |
| Tobeña, A | 1 |
| Fernández Teruel, A | 1 |
| Rodin, E | 1 |
| Onuma, T | 1 |
| Wasson, S | 1 |
| Porzak, J | 1 |
| Rodin, M | 1 |
| Browne, TR | 1 |
| Penry, JK | 1 |
| Parmar, SS | 3 |
| Dwivedi, C | 1 |
| Ali, B | 3 |
| Misra, RS | 1 |
| Joshi, PC | 2 |
| Cornatzer, WE | 1 |
| Adler, MW | 1 |
| Sagel, S | 1 |
| Kitagawa, S | 1 |
| Segawa, T | 1 |
| Maynert, EW | 1 |
| Hrcko, N | 1 |
| Osuide, G | 1 |
| Brumleve, SJ | 1 |
| Jami, L | 1 |
| Nelson, WL | 1 |
| Sherwood, BE | 1 |
| Straw, RN | 1 |
| Mitchell, CL | 1 |
| de Biolley, D | 1 |
| Sorel, L | 1 |
| de Casrilevitz, M | 1 |
| Engelhardt, E | 1 |
| Esbérard, CA | 1 |
| Sohn, YJ | 1 |
| Levitt, B | 1 |
| Raines, A | 1 |
| Millichap, JG | 1 |
| Pitchford, GL | 1 |
| Millichap, MG | 1 |
| Denhoff, E | 1 |
| Shammas, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Levetiracetam on Cortical Excitability in Humans[NCT00006191] | 14 participants | Observational | 2000-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pentylenetetrazole and Myoclonic Jerk
| Article | Year |
|---|---|
Benzodiazepines in the treatment of epilepsy. A review.
Topics: Adult; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Disease Models, Animal; Eclampsia; Elec | 1973 |
46 other studies available for pentylenetetrazole and Myoclonic Jerk
| Article | Year |
|---|---|
Vortioxetine suppresses epileptiform activity and cognition deficits in a chronic PTZ-induced kindling rat model.
Topics: Animals; Cognition; Disease Models, Animal; Male; Myoclonus; Pentylenetetrazole; Rats; Rats, Wistar; | 2021 |
Anticonvulsant activity of oxaprozin in a rat model of pentylenetetrazole-induced seizure by targeting oxidative stress and SIRT1/PGC1α signaling.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Glutathione; Myoclonus; Oxaprozin; Oxidative Stres | 2022 |
The Anti-Seizure Effect of Liraglutide on Ptz-Induced Convulsions Through its Anti-Oxidant and Anti-Inflammatory Properties.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Antioxidants; Disease Models, Animal; Epilepsy; | 2023 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
N-acetyl cysteine: A new look at its effect on PTZ-induced convulsions.
Topics: Acetylcysteine; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy; | 2023 |
Modulatory effects of neuropeptides on pentylenetetrazol-induced epileptic seizures and neuroinflammation in rats.
Topics: Animals; Biomarkers; Calcitonin Gene-Related Peptide; Convulsants; Disease Models, Animal; Ghrelin; | 2019 |
Beneficial Effects of Ibuprofen on Pentylenetetrazol-induced Convulsion.
Topics: Animals; Anticonvulsants; Dinoprost; Ibuprofen; Male; Myoclonus; Pentylenetetrazole; Rats, Sprague-D | 2020 |
A species dependent response to the pro-epileptic drug pentylentetrazole in birds.
Topics: Animals; Convulsants; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Immu | 2017 |
Assessment of the Anticonvulsant Potency of Ursolic Acid in Seizure Threshold Tests in Mice.
Topics: Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Electroshock; Male; Mice; M | 2018 |
Positive effect of calcitonin on the seizures induced by pentylenetetrazole in rats.
Topics: Analysis of Variance; Animals; Bone Density Conservation Agents; Brain Waves; Calcitonin; Convulsant | 2014 |
The association between seizure predisposition and inflammation in a rat model of fatty liver disease.
Topics: Animals; Brain; Convulsants; Disease Susceptibility; Electroencephalography; Fatty Liver; Fructose; | 2014 |
Positive effects of ceftriaxone on pentylenetetrazol-induced convulsion model in rats.
Topics: Animals; Anticonvulsants; Brain; Ceftriaxone; Convulsants; Dose-Response Relationship, Drug; Drug Ev | 2016 |
SB 334867, a selective orexin receptor type 1 antagonist, elevates seizure threshold in mice.
Topics: Animals; Anticonvulsants; Benzoxazoles; Brain Chemistry; Convulsants; Electroshock; Male; Mice; Musc | 2016 |
Effects of acute and repeated zolpidem treatment on pentylenetetrazole-induced seizure threshold and on locomotor activity: comparison with diazepam.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Administrati | 2009 |
Assessment of the seizure susceptibility of Wistar Audiogenic rat to electroshock, pentyleneterazole and pilocarpine.
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Convulsants; Disease Models, Animal; Electroshock; | 2003 |
Effect of acute versus chronic theophylline administration on acute restraint stress-induced increase of pentylenetetrazol seizure threshold in mice.
Topics: Acute Disease; Animals; Anticonvulsants; Chronic Disease; Convulsants; Dose-Response Relationship, D | 2006 |
[Involvement of endogenous histamine in modulatory effect of morphine on seizure susceptibility in mice].
Topics: Animals; Disease Susceptibility; Dose-Response Relationship, Drug; Histamine; Histidine Decarboxylas | 2007 |
[Progressive myoclonus epilepsy with Lafora bodies. Clinical and polygraphic study. Anatomical ultrastructural verification].
Topics: Adolescent; Brain; Cytoplasmic Granules; Diazepam; Electrocardiography; Electroencephalography; Elec | 1967 |
Neuropharmacological effects of isomers of hexachlorocyclohexane--2: Selective inhibition of (myo-)clonic seizures as a sequel to CNS excitation by the gama-isomer.
Topics: Animals; Anticonvulsants; Central Nervous System; Drug Tolerance; Hexachlorocyclohexane; Isomerism; | 1981 |
Strain differences in mice in the development of tolerance to the anti-pentylenetetrazole effects of diazepam.
Topics: Animals; Diazepam; Drug Tolerance; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Myoclonus; Pentylen | 1983 |
Interactions of two phenylquinolines with picrotoxin and benzodiazepines in vivo and in vitro.
Topics: Animals; Anticonvulsants; Benzodiazepines; Drug Interactions; gamma-Aminobutyric Acid; Male; Mice; M | 1984 |
Correlation between electrocorticographic and motor phenomena induced by pentamethylenetetrazol during ontogenesis in rats.
Topics: Animals; Brain; Electroencephalography; Myoclonus; Pentylenetetrazole; Rats; Rats, Inbred Strains; S | 1984 |
Experimental febrile convulsions: long-term effects of hyperthermia-induced convulsions in the developing rat.
Topics: Age Factors; Animals; Body Temperature; Growth; Hot Temperature; Myoclonus; Pentylenetetrazole; Rats | 1982 |
Effect of eboracin on convulsive seizures in mice: enhancement of myoclonus and inhibition of the tonic phase.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Electroshock; Indenes; Male; Mice; Myoclonus; Pentyl | 1982 |
6-Hydroxydopamine and Metrazol seizures in mice: inhibition of the tonic-clonic phase.
Topics: Animals; Drug Interactions; Hydroxydopamines; Mice; Myoclonus; Pentylenetetrazole; Seizures | 1980 |
Profile of ucb L059, a novel anticonvulsant drug, in models of partial and generalized epilepsy in mice and rats.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Electrodes; | 1993 |
[The dual role of the caudate nucleus in regulating seizures].
Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Brain Mapping; Cats; Caudate Nucleus; Cerebral | 1975 |
Relationship between kindled myoclonic seizures and feline brain dopamine metabolism.
Topics: Animals; Brain; Cats; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Female; Homovanil | 1978 |
[Effect of striatectomy on the course of corazole seizures in rats].
Topics: Animals; Apomorphine; Chlorpromazine; Corpus Striatum; Electroencephalography; Female; Haloperidol; | 1976 |
Chronic but not acute antidepressant treatment increases pentetrazol-induced convulsions in mice.
Topics: Animals; Antidepressive Agents; Desipramine; Drug Synergism; Imipramine; Male; Mice; Mice, Inbred St | 1989 |
Comparison of anticonvulsive properties of eboracin and phenytoin in mice.
Topics: Animals; Anticonvulsants; Indenes; Lethal Dose 50; Male; Mice; Myoclonus; Pentylenetetrazole; Phenyt | 1985 |
Neurophysiological mechanisms involved in grand mal seizures induced by Metrazol and Megimide.
Topics: Amygdala; Animals; Behavior, Animal; Bemegride; Brain; Cats; Caudate Nucleus; Cerebellum; Cerebral C | 1971 |
Anticonvulsant activity of nitrobenzamides and their inhibition of nicotinamide-adenine dinucleotide dependent oxidations.
Topics: Amides; Animals; Anticonvulsants; Benzoates; Brain; Female; Male; Mice; Myoclonus; NAD; Nitro Compou | 1972 |
Anticonvulsant activity and inhibition of respiration in rat brain homogenates by substituted oxadiazoles.
Topics: Animals; Anticonvulsants; Brain; Cyclization; Depression, Chemical; Female; In Vitro Techniques; Ket | 1974 |
The effects of repeated flurothyl-induced seizures on convulsive thresholds and brain monoamines in rats.
Topics: Animals; Brain; Brain Chemistry; Central Nervous System Stimulants; Dopamine; Electroshock; Male; My | 1967 |
[Effect of chlorpromazine on the convulsive threshold in rats].
Topics: Animals; Central Nervous System Stimulants; Chlorpromazine; Drug Synergism; Electroencephalography; | 1967 |
Effects of gamma-hydroxybutyrate on chick behaviour, electrocortical activity and crossed extensor reflexes.
Topics: Action Potentials; Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Stimulants; Ce | 1972 |
Synthesis of substituted cinnamides: relationship between anticonvulsant and monoamine oxidase inhibitory properties.
Topics: Amides; Animals; Anticonvulsants; Cinnamates; Manometry; Mice; Monoamine Oxidase Inhibitors; Myoclon | 1973 |
Activity of alpha and gamma extensor motor axons during metrazol-induced seizures in cat.
Topics: Action Potentials; Animals; Cats; Cerebral Decortication; Disease Models, Animal; Electroencephalogr | 1974 |
Centrally acting muscle relaxants. Isomeric 9,10-dihydroxy-1,2,3,4,4a,9,10,10a(trans-4a,10a)-octahydrophenanthrenes and their carbamate esters.
Topics: Animals; Carbamates; Electroshock; Male; Mass Spectrometry; Mice; Molecular Conformation; Motor Acti | 1974 |
Study on the paroxysmal bioelectrical activity and overt seizure patterns elicited by pentylenetetrazol in the cat.
Topics: Animals; Behavior, Animal; Brain; Cats; Electrophysiology; Female; Male; Myoclonus; Pentylenetetrazo | 1967 |
[Experimental and clinical results of a new anti-epileptic: sodium di-n-propyl acetate (DPA) specialized under the marketed name, Depakine. Second study].
Topics: Acetates; Adolescent; Animals; Anticonvulsants; Behavior; Child; Child, Preschool; Electroencephalog | 1969 |
Maturation of convulsogenic activity induced by leptazol in the albino rat.
Topics: Age Factors; Animals; Body Weight; Brain Stem; Catalepsy; Central Nervous System; Female; Humans; In | 1971 |
Anticonvulsant properties of diphenylthiohydantoin.
Topics: Animals; Drug Antagonism; Electroencephalography; Electroshock; Hindlimb; Male; Myoclonus; Pentylene | 1970 |
Anticonvulsant activity of antiparkinsonism agents.
Topics: Animals; Anticonvulsants; Child; Child, Preschool; Electroshock; Female; Glaucoma; Humans; Infant; M | 1968 |
Diazepam as an aid in the photo-Metrazol activation test.
Topics: Adolescent; Child; Child Behavior Disorders; Child, Preschool; Diazepam; Electroencephalography; Fem | 1968 |