pentylenetetrazole has been researched along with Memory Disorders in 48 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Memory Disorders: Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Flurothyl inhalation-induced seizures were as clinically effective as electrical inductions with lesser effects on memory functions." | 8.90 | The chemical induction of seizures in psychiatric therapy: were flurothyl (indoklon) and pentylenetetrazol (metrazol) abandoned prematurely? ( Cooper, K; Fink, M, 2014) |
| " Here, we conducted present study to evaluate its neuroprotective effects against pentylenetetrazole (PTZ)-induced seizures in rats." | 8.31 | (-)-α-bisabolol exerts neuroprotective effects against pentylenetetrazole-induced seizures in rats by targeting inflammation and oxidative stress. ( Hashemi, P; Moslehi, A; Nazarinia, D, 2023) |
| " In this regard, the effects of oxaprozin (OXP) (a nonsteroidal anti-inflammatory drug) on the experimental model of seizure and memory impairment caused by seizures in rats were investigated in the present study." | 8.12 | Nonsteroidal Anti-inflammatory Drug Oxaprozin is Beneficial Against Seizure-induced Memory Impairment in an Experimental Model of Seizures in Rats: Impact On Oxidative Stress and Nrf2/HO-1 Signaling Pathway. ( Bananej, M; Khatami, P; Khosravi, M; Mirazi, N, 2022) |
| " This study was envisaged to evaluate the ameliorative effect of Curcumin on depression like behavior and cognitive impairment observed in pentylenetetrazole kindled animals." | 7.79 | Ameliorative effect of Curcumin on seizure severity, depression like behavior, learning and memory deficit in post-pentylenetetrazole-kindled mice. ( Choudhary, KM; Goel, RK; Mishra, A; Poroikov, VV, 2013) |
| "PTZ-kindled epilepsy causes memory impairment, and it might be due to a decrease of brain histamine and loss of hippocampal neurons induced by epilepsy." | 7.73 | [Effects of endogenous histamine on memory impairment induced by pentylenetetrazole-kindled epilepsy in rats]. ( Li, Q; Ma, YY; Zhang, LS, 2006) |
| " Alphaxalone (up to 5 mg/kg) did not exert a significant action against amygdala-kindled seizures in rats, or against pentetrazole- or aminophylline-induced convulsions in mice." | 7.71 | Interaction of the neurosteroid alphaxalone with conventional antiepileptic drugs in different types of experimental seizures. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Kowalska, A; Swiader, M; Zadrozniak, M, 2002) |
| "With a focus on PTZ seizures, the major biochemicals, as well as morphological alterations and the modulated brain neurotransmitter levels associated with memory deficits have been illustrated." | 6.66 | Experimental Models for the Discovery of Novel Anticonvulsant Drugs: Focus on Pentylenetetrazole-Induced Seizures and Associated Memory Deficits. ( Adem, A; Alachkar, A; Frank, A; Ojha, SK; Sadek, B; Sadeq, A; Stark, H, 2020) |
| "Previous studies have shown that seizures can cause cognitive disorders." | 5.56 | Effect of Curcuma zedoaria hydro-alcoholic extract on learning, memory deficits and oxidative damage of brain tissue following seizures induced by pentylenetetrazole in rat. ( Arabi, M; Bijad, E; Kazemi, S; Lorigooini, Z; Mahmoudi, T; Rabiei, Z; Rafieian-Kopaei, M, 2020) |
| "Metformin was injected intraperitoneally in dose of 200mg/kg along with alternate-day PTZ." | 5.40 | Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice. ( Liu, LM; Wang, WP; Xu, F; Xu, XC; Zhang, WL; Zhao, RR, 2014) |
| " Flurothyl inhalation-induced seizures were as clinically effective as electrical inductions with lesser effects on memory functions." | 4.90 | The chemical induction of seizures in psychiatric therapy: were flurothyl (indoklon) and pentylenetetrazol (metrazol) abandoned prematurely? ( Cooper, K; Fink, M, 2014) |
| " Here, we conducted present study to evaluate its neuroprotective effects against pentylenetetrazole (PTZ)-induced seizures in rats." | 4.31 | (-)-α-bisabolol exerts neuroprotective effects against pentylenetetrazole-induced seizures in rats by targeting inflammation and oxidative stress. ( Hashemi, P; Moslehi, A; Nazarinia, D, 2023) |
| " In this regard, the effects of oxaprozin (OXP) (a nonsteroidal anti-inflammatory drug) on the experimental model of seizure and memory impairment caused by seizures in rats were investigated in the present study." | 4.12 | Nonsteroidal Anti-inflammatory Drug Oxaprozin is Beneficial Against Seizure-induced Memory Impairment in an Experimental Model of Seizures in Rats: Impact On Oxidative Stress and Nrf2/HO-1 Signaling Pathway. ( Bananej, M; Khatami, P; Khosravi, M; Mirazi, N, 2022) |
| " Epilepsy-associated comorbid depression was evaluated by tail suspension test, sucrose preference test, and plasma corticosterone levels, whereas epilepsy-associated memory deficit condition was assessed by step-through paradigm, Morris water maze, and nitrite levels." | 3.96 | Exploring the ameliorative role of α7 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice. ( Goel, RK; Kaur, S; Sharma, NK, 2020) |
| " This study was envisaged to evaluate the ameliorative effect of Curcumin on depression like behavior and cognitive impairment observed in pentylenetetrazole kindled animals." | 3.79 | Ameliorative effect of Curcumin on seizure severity, depression like behavior, learning and memory deficit in post-pentylenetetrazole-kindled mice. ( Choudhary, KM; Goel, RK; Mishra, A; Poroikov, VV, 2013) |
| "PTZ-kindled epilepsy causes memory impairment, and it might be due to a decrease of brain histamine and loss of hippocampal neurons induced by epilepsy." | 3.73 | [Effects of endogenous histamine on memory impairment induced by pentylenetetrazole-kindled epilepsy in rats]. ( Li, Q; Ma, YY; Zhang, LS, 2006) |
| " Alphaxalone (up to 5 mg/kg) did not exert a significant action against amygdala-kindled seizures in rats, or against pentetrazole- or aminophylline-induced convulsions in mice." | 3.71 | Interaction of the neurosteroid alphaxalone with conventional antiepileptic drugs in different types of experimental seizures. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Kowalska, A; Swiader, M; Zadrozniak, M, 2002) |
| "With a focus on PTZ seizures, the major biochemicals, as well as morphological alterations and the modulated brain neurotransmitter levels associated with memory deficits have been illustrated." | 2.66 | Experimental Models for the Discovery of Novel Anticonvulsant Drugs: Focus on Pentylenetetrazole-Induced Seizures and Associated Memory Deficits. ( Adem, A; Alachkar, A; Frank, A; Ojha, SK; Sadek, B; Sadeq, A; Stark, H, 2020) |
| "Epilepsy is characterized by recurrent seizures, which are caused by excessive discharges from cerebral neurons." | 2.48 | [Impaired memory following repeated pentylenetetrazol treatments in kindled mice]. ( Araki, H; Kawasaki, H; Suemaru, K; Takechi, K, 2012) |
| "Recurrent seizures induce some cognitive problems, such as, depression, learning and memory deficits, and neurodegeneration." | 1.56 | Betahistine, prevents kindling, ameliorates the behavioral comorbidities and neurodegeneration induced by pentylenetetrazole. ( Beheshti, S; Doostmohammadi, M; Pourhossein Majarshin, F; Yazdi, A, 2020) |
| "Previous studies have shown that seizures can cause cognitive disorders." | 1.56 | Effect of Curcuma zedoaria hydro-alcoholic extract on learning, memory deficits and oxidative damage of brain tissue following seizures induced by pentylenetetrazole in rat. ( Arabi, M; Bijad, E; Kazemi, S; Lorigooini, Z; Mahmoudi, T; Rabiei, Z; Rafieian-Kopaei, M, 2020) |
| "The susceptibility to epileptic seizures is dependent on sex as well as fluctuations in oestrogen levels, while exogenous oestrogen was shown to have no effect or to facilitate or to inhibit seizure activity." | 1.51 | Oestrogen receptor ERα and ERβ agonists ameliorate oxidative brain injury and improve memory dysfunction in rats with an epileptic seizure. ( Akakın, D; Arabacı Tamer, S; Erzik, C; Karagöz, A; Koyuncuoğlu, T; Yeğen, BÇ; Yüksel, M, 2019) |
| "Epilepsy is a complicated neurological disorder that occurs worldwide and features several kinds of comorbidities in addition to recurrent seizures." | 1.48 | Adenosine A1 Receptors Play an Important Protective Role Against Cognitive Impairment and Long-Term Potentiation Inhibition in a Pentylenetetrazol Mouse Model of Epilepsy. ( Guo, Y; Hu, Q; Kang, H; Lian, L; Liu, X; Xu, F; Zhang, N; Zhou, Q; Zhu, S, 2018) |
| " The results indicated that although chronic administration of phenytoin inhibited the development of PTZ kindling, it did not exert a protective effect against kindling-induced spatial learning and memory impairment in rats." | 1.48 | Improving effect of mild foot electrical stimulation on pentylenetetrazole-induced impairment of learning and memory. ( Abasi-Moghadam, M; Ghasemi-Dehno, A; Palizvan, MR; Sadegh, M, 2018) |
| "Lafora disease is caused by loss-of-function mutations in either the EPM2A or EPM2B genes." | 1.46 | Sodium selenate treatment improves symptoms and seizure susceptibility in a malin-deficient mouse model of Lafora disease. ( Sánchez, MP; Sánchez-Elexpuru, G; Serratosa, JM, 2017) |
| "The ketogenic diet (KD) controls seizure and improves cognition in patients with drug refractory epilepsy." | 1.43 | Ketogenic diet attenuates spatial and item memory impairment in pentylenetetrazol-kindled rats. ( Hou, Q; Jia, M; Jiang, Y; Lu, Y; Wang, B; Wang, X; Zhang, Z, 2016) |
| "Metformin was injected intraperitoneally in dose of 200mg/kg along with alternate-day PTZ." | 1.40 | Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice. ( Liu, LM; Wang, WP; Xu, F; Xu, XC; Zhang, WL; Zhao, RR, 2014) |
| "Malondialdehyde (MDA) levels were significantly increased in the quercetin groups compared to the PTZ group in the hippocampus and cerebral cortex following PTZ kindling." | 1.39 | Effects of quercetin on oxidative stress and memory retrieval in kindled rats. ( Abbasi, E; Bazahang, P; Haghighi, MR; Lotfizadeh, M; Moghbelinejad, S; Nassiri-Asl, M; Yonesi, F, 2013) |
| "Thioperamide plays a protective role in seizure development and cognitive impairment of PTZ-induced kindling in rats." | 1.39 | Effects of thioperamide on seizure development and memory impairment induced by pentylenetetrazole-kindling epilepsy in rats. ( Chen, GF; Chen, JF; Ding, MP; Hu, XY; Zhang, LS, 2013) |
| "Epilepsy is a chronic neurological disorder and well documented to induce cognitive impairment." | 1.38 | Age dependent learning and memory deficit in Pentylenetetrazol kindled mice. ( Goel, RK; Mishra, A, 2012) |
| "Memantine has been approved to treat moderate to severe Alzheimer disease (AD), which is characterized by cognitive impairment." | 1.37 | Memantine attenuates the impairment of spatial learning and memory of pentylenetetrazol-kindled rats. ( An, LW; Duan, RS; Jia, LJ; Li, ZP; Wang, WP; Zhen, JL, 2011) |
| "Pentylenetetrazole (PTZ) is a chemical kindling agent used to examine the efficacy of potential anticonvulsants in rats." | 1.33 | Spatial learning deficits and emotional impairments in pentylenetetrazole-kindled rats. ( Dunbar, GL; Ericson, M; Hulce, VD; Mortazavi, F; Story, D, 2005) |
| "PTZ kindling induced a retrograde amnesia in the active and passive avoidance situations." | 1.29 | Pentylenetetrazole kindling impairs long-term memory in rats. ( Genkova-Papazova, MG; Lazarova-Bakarova, MB, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.08) | 18.2507 |
| 2000's | 8 (16.67) | 29.6817 |
| 2010's | 26 (54.17) | 24.3611 |
| 2020's | 13 (27.08) | 2.80 |
| Authors | Studies |
|---|---|
| Khatami, P | 2 |
| Mirazi, N | 1 |
| Khosravi, M | 1 |
| Bananej, M | 1 |
| Pollo, MLM | 1 |
| Gimenes, C | 1 |
| Covolan, L | 1 |
| Nkwingwa, BK | 1 |
| Wado, EK | 1 |
| Foyet, HS | 1 |
| Bouvourne, P | 1 |
| Jugha, VT | 1 |
| Mambou, AHMY | 1 |
| Bila, RB | 1 |
| Taiwe, GS | 1 |
| Nazarinia, D | 1 |
| Moslehi, A | 1 |
| Hashemi, P | 1 |
| Canzian, J | 1 |
| Müller, TE | 1 |
| Franscescon, F | 1 |
| Michelotti, P | 1 |
| Fontana, BD | 1 |
| Costa, FV | 1 |
| Rosemberg, DB | 1 |
| Koyuncuoğlu, T | 1 |
| Arabacı Tamer, S | 1 |
| Erzik, C | 1 |
| Karagöz, A | 1 |
| Akakın, D | 1 |
| Yüksel, M | 1 |
| Yeğen, BÇ | 1 |
| Sharma, NK | 1 |
| Kaur, S | 1 |
| Goel, RK | 8 |
| Alachkar, A | 3 |
| Ojha, SK | 2 |
| Sadeq, A | 1 |
| Adem, A | 1 |
| Frank, A | 1 |
| Stark, H | 1 |
| Sadek, B | 3 |
| Yazdi, A | 1 |
| Doostmohammadi, M | 1 |
| Pourhossein Majarshin, F | 1 |
| Beheshti, S | 1 |
| Azimullah, S | 1 |
| Lotfy, M | 2 |
| Adeghate, E | 2 |
| Beiram, R | 1 |
| Łażewska, D | 2 |
| Kieć-Kononowicz, K | 2 |
| Mahmoudi, T | 1 |
| Lorigooini, Z | 1 |
| Rafieian-Kopaei, M | 1 |
| Arabi, M | 1 |
| Rabiei, Z | 1 |
| Bijad, E | 1 |
| Kazemi, S | 1 |
| Mishra, P | 1 |
| Mittal, AK | 1 |
| Rajput, SK | 1 |
| Sinha, JK | 1 |
| Wang, X | 2 |
| Huang, S | 1 |
| Liu, Y | 1 |
| Li, D | 1 |
| Dang, Y | 1 |
| Yang, L | 1 |
| Aghaie, F | 1 |
| Shemshaki, A | 1 |
| Rajabi, M | 1 |
| Hosseini, A | 1 |
| Zhou, Q | 1 |
| Zhu, S | 1 |
| Guo, Y | 1 |
| Lian, L | 1 |
| Hu, Q | 1 |
| Liu, X | 1 |
| Xu, F | 2 |
| Zhang, N | 1 |
| Kang, H | 1 |
| Hashemian, M | 1 |
| Anissian, D | 1 |
| Ghasemi-Kasman, M | 1 |
| Akbari, A | 1 |
| Khalili-Fomeshi, M | 1 |
| Ghasemi, S | 1 |
| Ahmadi, F | 1 |
| Moghadamnia, AA | 1 |
| Ebrahimpour, A | 1 |
| Abasi-Moghadam, M | 1 |
| Ghasemi-Dehno, A | 1 |
| Sadegh, M | 1 |
| Palizvan, MR | 1 |
| Choudhary, KM | 1 |
| Mishra, A | 5 |
| Poroikov, VV | 1 |
| Nassiri-Asl, M | 1 |
| Moghbelinejad, S | 1 |
| Abbasi, E | 1 |
| Yonesi, F | 1 |
| Haghighi, MR | 1 |
| Lotfizadeh, M | 1 |
| Bazahang, P | 1 |
| Zhao, RR | 1 |
| Xu, XC | 1 |
| Zhang, WL | 2 |
| Liu, LM | 1 |
| Wang, WP | 3 |
| Cooper, K | 1 |
| Fink, M | 1 |
| Katyal, J | 1 |
| Kumar, H | 1 |
| Gupta, YK | 2 |
| Wang, Y | 1 |
| Fisahn, A | 1 |
| Sinha, I | 1 |
| Nguyen, DP | 1 |
| Sterzenbach, U | 1 |
| Lallemend, F | 1 |
| Hadjab, S | 1 |
| Pahwa, P | 2 |
| Jiang, Y | 1 |
| Lu, Y | 1 |
| Jia, M | 1 |
| Zhang, Z | 1 |
| Hou, Q | 1 |
| Wang, B | 1 |
| Dhediya, RM | 1 |
| Joshi, SS | 1 |
| Gajbhiye, SV | 1 |
| Jalgaonkar, SV | 1 |
| Biswas, M | 1 |
| Kaur, D | 1 |
| Sánchez-Elexpuru, G | 1 |
| Serratosa, JM | 1 |
| Sánchez, MP | 1 |
| Zhang, CS | 1 |
| Bertaso, F | 1 |
| Eulenburg, V | 1 |
| Lerner-Natoli, M | 1 |
| Herin, GA | 1 |
| Bauer, L | 1 |
| Bockaert, J | 1 |
| Fagni, L | 1 |
| Betz, H | 1 |
| Scheschonka, A | 1 |
| Stone, SS | 1 |
| Teixeira, CM | 1 |
| Zaslavsky, K | 1 |
| Wheeler, AL | 1 |
| Martinez-Canabal, A | 1 |
| Wang, AH | 1 |
| Sakaguchi, M | 1 |
| Lozano, AM | 1 |
| Frankland, PW | 1 |
| Uzüm, G | 1 |
| Akgün-Dar, K | 1 |
| Aksu, U | 1 |
| Jia, LJ | 1 |
| Li, ZP | 1 |
| Zhen, JL | 1 |
| An, LW | 1 |
| Duan, RS | 2 |
| Takechi, K | 1 |
| Suemaru, K | 1 |
| Kawasaki, H | 1 |
| Araki, H | 1 |
| Pahuja, M | 1 |
| Mehla, J | 1 |
| Reeta, KH | 1 |
| Tripathi, M | 1 |
| Zhang, LS | 3 |
| Chen, JF | 1 |
| Chen, GF | 1 |
| Hu, XY | 1 |
| Ding, MP | 1 |
| Singh, D | 1 |
| Borowicz, KK | 1 |
| Zadrozniak, M | 1 |
| Swiader, M | 1 |
| Kowalska, A | 1 |
| Kleinrok, Z | 1 |
| Czuczwar, SJ | 1 |
| Jin, CL | 1 |
| Li, Q | 2 |
| Sun, YC | 1 |
| Chen, Z | 1 |
| Mortazavi, F | 1 |
| Ericson, M | 1 |
| Story, D | 1 |
| Hulce, VD | 1 |
| Dunbar, GL | 1 |
| Jia, F | 1 |
| Kato, M | 1 |
| Dai, H | 1 |
| Xu, A | 1 |
| Okuda, T | 1 |
| Sakurai, E | 1 |
| Okamura, N | 1 |
| Lovenberg, TW | 1 |
| Barbier, A | 1 |
| Carruthers, NI | 1 |
| Iinuma, K | 1 |
| Yanai, K | 1 |
| Ma, YY | 1 |
| Rueda, N | 1 |
| Flórez, J | 1 |
| Martínez-Cué, C | 1 |
| Lou, Y | 1 |
| Li, P | 1 |
| Chen, WH | 1 |
| Genkova-Papazova, MG | 1 |
| Lazarova-Bakarova, MB | 1 |
3 reviews available for pentylenetetrazole and Memory Disorders
| Article | Year |
|---|---|
Experimental Models for the Discovery of Novel Anticonvulsant Drugs: Focus on Pentylenetetrazole-Induced Seizures and Associated Memory Deficits.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Memory D | 2020 |
The chemical induction of seizures in psychiatric therapy: were flurothyl (indoklon) and pentylenetetrazol (metrazol) abandoned prematurely?
Topics: Animals; Electroconvulsive Therapy; Flurothyl; Humans; Memory Disorders; Mental Disorders; Pentylene | 2014 |
[Impaired memory following repeated pentylenetetrazol treatments in kindled mice].
Topics: Animals; Disease Models, Animal; Epilepsy; Kindling, Neurologic; Memory; Memory Disorders; Mice; Mot | 2012 |
45 other studies available for pentylenetetrazole and Memory Disorders
| Article | Year |
|---|---|
Nonsteroidal Anti-inflammatory Drug Oxaprozin is Beneficial Against Seizure-induced Memory Impairment in an Experimental Model of Seizures in Rats: Impact On Oxidative Stress and Nrf2/HO-1 Signaling Pathway.
Topics: Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Male; Memory Disorders; Models, Theo | 2022 |
Male rats are more vulnerable to pentylenetetrazole-kindling model but females have more spatial memory-related deficits.
Topics: Animals; Female; Humans; Kindling, Neurologic; Male; Memory Disorders; Pentylenetetrazole; Rats; Rat | 2022 |
Ameliorative effects of Albizia adianthifolia aqueous extract against pentylenetetrazole-induced epilepsy and associated memory loss in mice: Role of GABAergic, antioxidant defense and anti-inflammatory systems.
Topics: Albizzia; Amnesia; Animals; Anti-Inflammatory Agents; Anticonvulsants; Antioxidants; Epilepsy; gamma | 2023 |
(-)-α-bisabolol exerts neuroprotective effects against pentylenetetrazole-induced seizures in rats by targeting inflammation and oxidative stress.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Inflammation; Male; Memory Disorders; Ne | 2023 |
Modeling psychiatric comorbid symptoms of epileptic seizures in zebrafish.
Topics: Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Female; GABA Antagonists; Humans; Locomo | 2019 |
Oestrogen receptor ERα and ERβ agonists ameliorate oxidative brain injury and improve memory dysfunction in rats with an epileptic seizure.
Topics: Animals; Avoidance Learning; Brain Injuries; Estrogen Receptor alpha; Estrogen Receptor beta; Male; | 2019 |
Exploring the ameliorative role of α7 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anticonvulsants; Corticosterone; Depression; Dose- | 2020 |
Betahistine, prevents kindling, ameliorates the behavioral comorbidities and neurodegeneration induced by pentylenetetrazole.
Topics: Animals; Anticonvulsants; Betahistine; Hippocampus; Kindling, Neurologic; Male; Memory Disorders; Mi | 2020 |
Antagonism of Histamine H3 receptors Alleviates Pentylenetetrazole-Induced Kindling and Associated Memory Deficits by Mitigating Oxidative Stress, Central Neurotransmitters, and c-Fos Protein Expression in Rats.
Topics: Animals; Epilepsy; Gene Expression Regulation; Hippocampus; Histamine H3 Antagonists; Kindling, Neur | 2020 |
Effect of Curcuma zedoaria hydro-alcoholic extract on learning, memory deficits and oxidative damage of brain tissue following seizures induced by pentylenetetrazole in rat.
Topics: Animals; Anticonvulsants; Antioxidants; Brain Chemistry; Convulsants; Curcuma; Flumazenil; GABA Modu | 2020 |
Cognition and memory impairment attenuation via reduction of oxidative stress in acute and chronic mice models of epilepsy using antiepileptogenic Nux vomica.
Topics: Acute Disease; Animals; Anticonvulsants; Antioxidants; Behavior, Animal; Brain; Chronic Disease; Cog | 2021 |
Effects of ketogenic diet on cognitive function in pentylenetetrazol-kindled rats.
Topics: Animals; Cognition; Diet, Ketogenic; Humans; Kindling, Neurologic; Memory Disorders; Pentylenetetraz | 2021 |
Ameliorating effects of histamine H3 receptor antagonist E177 on acute pentylenetetrazole-induced memory impairments in rats.
Topics: Animals; Behavior, Animal; Disease Models, Animal; GABA Antagonists; Hippocampus; Histamine H3 Antag | 2021 |
Rapamycin alleviates memory deficit against pentylenetetrazole-induced neural toxicity in Wistar male rats.
Topics: Animals; Brain; Disease Models, Animal; Kindling, Neurologic; Male; Memory; Memory Disorders; Neuron | 2021 |
Adenosine A1 Receptors Play an Important Protective Role Against Cognitive Impairment and Long-Term Potentiation Inhibition in a Pentylenetetrazol Mouse Model of Epilepsy.
Topics: Animals; Caspase 3; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, | 2018 |
Curcumin-loaded chitosan-alginate-STPP nanoparticles ameliorate memory deficits and reduce glial activation in pentylenetetrazol-induced kindling model of epilepsy.
Topics: Animals; Anticonvulsants; Brain; Chronic Disease; Curcumin; Disease Models, Animal; Dose-Response Re | 2017 |
Improving effect of mild foot electrical stimulation on pentylenetetrazole-induced impairment of learning and memory.
Topics: Animals; Electric Stimulation Therapy; Kindling, Neurologic; Male; Memory; Memory Disorders; Pentyle | 2018 |
Ameliorative effect of Curcumin on seizure severity, depression like behavior, learning and memory deficit in post-pentylenetetrazole-kindled mice.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Behavior, Animal; Brain; Convulsants; Curcumin; Depr | 2013 |
Effects of quercetin on oxidative stress and memory retrieval in kindled rats.
Topics: Animals; Antioxidants; Avoidance Learning; Brain; Convulsants; Disease Models, Animal; Dithionitrobe | 2013 |
Psychoneurochemical investigations to reveal neurobiology of memory deficit in epilepsy.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Chromatography, High Pressure Liquid; Convul | 2013 |
Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice.
Topics: Animals; Antioxidants; Brain; Convulsants; Glutathione; Kindling, Neurologic; Learning Disabilities; | 2014 |
Anticonvulsant activity of the cyclooxygenase-2 (COX-2) inhibitor etoricoxib in pentylenetetrazole-kindled rats is associated with memory impairment.
Topics: Animals; Anticonvulsants; Behavior, Animal; Convulsants; Cyclooxygenase 2 Inhibitors; Etoricoxib; Ki | 2015 |
Hippocampal Transcriptome Profile of Persistent Memory Rescue in a Mouse Model of THRA1 Mutation-Mediated Resistance to Thyroid Hormone.
Topics: Animals; CA1 Region, Hippocampal; Dendritic Spines; Disease Models, Animal; Excitatory Postsynaptic | 2016 |
Ameliorative effect of Asparagus racemosus root extract against pentylenetetrazol-induced kindling and associated depression and memory deficit.
Topics: Animals; Anticonvulsants; Asparagus Plant; Depression; Dose-Response Relationship, Drug; Epilepsy; K | 2016 |
Ketogenic diet attenuates spatial and item memory impairment in pentylenetetrazol-kindled rats.
Topics: Animals; Body Weight; Diet, Ketogenic; Kindling, Neurologic; Male; Maze Learning; Memory Disorders; | 2016 |
Evaluation of antiepileptic effect of S-adenosyl methionine and its role in memory impairment in pentylenetetrazole-induced kindling model in rats.
Topics: Animals; Anticonvulsants; Brain Chemistry; Cognition; Convulsants; Dose-Response Relationship, Drug; | 2016 |
Protective Effect of Nerolidol Against Pentylenetetrazol-Induced Kindling, Oxidative Stress and Associated Behavioral Comorbidities in Mice.
Topics: Animals; Behavior, Animal; Comorbidity; Depression; Glutathione; Kindling, Neurologic; Male; Memory | 2016 |
Chronic 5-HT
Topics: Animals; Anticonvulsants; Biguanides; Cerebral Cortex; Dose-Response Relationship, Drug; Hippocampus | 2016 |
Sodium selenate treatment improves symptoms and seizure susceptibility in a malin-deficient mouse model of Lafora disease.
Topics: Animals; Antioxidants; Anxiety; Convulsants; Disease Models, Animal; Dual-Specificity Phosphatases; | 2017 |
Knock-in mice lacking the PDZ-ligand motif of mGluR7a show impaired PKC-dependent autoinhibition of glutamate release, spatial working memory deficits, and increased susceptibility to pentylenetetrazol.
Topics: Amino Acid Motifs; Animals; Behavior, Animal; Brain; Carrier Proteins; Cell Cycle Proteins; Cells, C | 2008 |
Functional convergence of developmentally and adult-generated granule cells in dentate gyrus circuits supporting hippocampus-dependent memory.
Topics: Age Factors; Animals; Avoidance Learning; Conditioning, Classical; Convulsants; Crosses, Genetic; Cy | 2011 |
The effects of atorvastatin on memory deficit and seizure susceptibility in pentylentetrazole-kindled rats.
Topics: Analysis of Variance; Animals; Anticholesteremic Agents; Atorvastatin; Avoidance Learning; Disease S | 2010 |
Memantine attenuates the impairment of spatial learning and memory of pentylenetetrazol-kindled rats.
Topics: Animals; Behavior, Animal; Convulsants; Excitatory Amino Acid Antagonists; Kindling, Neurologic; Lea | 2011 |
Age dependent learning and memory deficit in Pentylenetetrazol kindled mice.
Topics: Aging; Animals; Behavior, Animal; Disease Models, Animal; Epilepsy; Feasibility Studies; Learning; M | 2012 |
Effect of Anacyclus pyrethrum on pentylenetetrazole-induced kindling, spatial memory, oxidative stress and rho-kinase II expression in mice.
Topics: Animals; Asteraceae; Glutathione; Kindling, Neurologic; Male; Maze Learning; Memory; Memory Disorder | 2013 |
Effects of thioperamide on seizure development and memory impairment induced by pentylenetetrazole-kindling epilepsy in rats.
Topics: Animals; Anticonvulsants; Cyclic AMP Response Element-Binding Protein; Histamine H3 Antagonists; Kin | 2013 |
Effect of saponin fraction from Ficus religiosa on memory deficit, and behavioral and biochemical impairments in pentylenetetrazol kindled mice.
Topics: Analysis of Variance; Animals; Avoidance Learning; Brain; Chromatography, High Pressure Liquid; Depr | 2013 |
Interaction of the neurosteroid alphaxalone with conventional antiepileptic drugs in different types of experimental seizures.
Topics: Aminophylline; Amygdala; Anesthetics; Animals; Anticonvulsants; Avoidance Learning; Convulsants; Dru | 2002 |
[Influence of chronic epilepsy on spatial memory retrieval in rats].
Topics: Animals; Benzazepines; Chronic Disease; Dose-Response Relationship, Drug; Epilepsy; Male; Maze Learn | 2004 |
Spatial learning deficits and emotional impairments in pentylenetetrazole-kindled rats.
Topics: Affective Symptoms; Animals; Behavior, Animal; Convulsants; Disease Models, Animal; Hippocampus; Kin | 2005 |
Effects of histamine H(3) antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice.
Topics: Animals; Avoidance Learning; Convulsants; Donepezil; Electric Stimulation; Female; Histamine Antagon | 2006 |
[Effects of endogenous histamine on memory impairment induced by pentylenetetrazole-kindled epilepsy in rats].
Topics: Animals; Epilepsy; Hippocampus; Histamine; Kindling, Neurologic; Male; Memory Disorders; Neurons; Pe | 2006 |
Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome.
Topics: Acetylcholine; Animals; Brain; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Disease Mod | 2008 |
[Changes in learning and memory functions in rats with status epilepticus and generalized nonconvulsive status epilepticus].
Topics: Animals; CREB-Binding Protein; Hippocampus; Kindling, Neurologic; Maze Learning; Memory Disorders; P | 2008 |
Pentylenetetrazole kindling impairs long-term memory in rats.
Topics: Amnesia, Retrograde; Animals; Avoidance Learning; Kindling, Neurologic; Male; Memory Disorders; Pent | 1995 |