pentylenetetrazole has been researched along with Learning Disabilities in 14 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Learning Disabilities: Conditions characterized by a significant discrepancy between an individual's perceived level of intellect and their ability to acquire new language and other cognitive skills. These may result from organic or psychological conditions. Relatively common subtypes include DYSLEXIA, DYSCALCULIA, and DYSGRAPHIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous studies have shown that seizures can cause cognitive disorders." | 5.56 | Effect of Curcuma zedoaria hydro-alcoholic extract on learning, memory deficits and oxidative damage of brain tissue following seizures induced by pentylenetetrazole in rat. ( Arabi, M; Bijad, E; Kazemi, S; Lorigooini, Z; Mahmoudi, T; Rabiei, Z; Rafieian-Kopaei, M, 2020) |
| "Metformin was injected intraperitoneally in dose of 200mg/kg along with alternate-day PTZ." | 5.40 | Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice. ( Liu, LM; Wang, WP; Xu, F; Xu, XC; Zhang, WL; Zhao, RR, 2014) |
| " To test the effect of antiepileptic drugs on kindled seizures and kindling-induced learning deficits we injected ethosuximide, dipropylacetate, and phenobarbital prior to each kindling stimulation or after kindling completion, and tested these animals in a shuttle-box paradigm." | 3.69 | Antiepileptic drugs--their effects on kindled seizures and kindling-induced learning impairments. ( Becker, A; Brosz, M; Grecksch, G, 1995) |
| "Previous studies have shown that seizures can cause cognitive disorders." | 1.56 | Effect of Curcuma zedoaria hydro-alcoholic extract on learning, memory deficits and oxidative damage of brain tissue following seizures induced by pentylenetetrazole in rat. ( Arabi, M; Bijad, E; Kazemi, S; Lorigooini, Z; Mahmoudi, T; Rabiei, Z; Rafieian-Kopaei, M, 2020) |
| "Metformin was injected intraperitoneally in dose of 200mg/kg along with alternate-day PTZ." | 1.40 | Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice. ( Liu, LM; Wang, WP; Xu, F; Xu, XC; Zhang, WL; Zhao, RR, 2014) |
| "Memantine has been approved to treat moderate to severe Alzheimer disease (AD), which is characterized by cognitive impairment." | 1.37 | Memantine attenuates the impairment of spatial learning and memory of pentylenetetrazol-kindled rats. ( An, LW; Duan, RS; Jia, LJ; Li, ZP; Wang, WP; Zhen, JL, 2011) |
| "Seizures were terminated 30min later by ketamine (50mg/kg, i." | 1.32 | NMDA-induced seizures in developing rats cause long-term learning impairment and increased seizure susceptibility. ( Sasaki-Adams, DM; Stafstrom, CE, 2003) |
| "Besides the seizure development, the kindling induced enhancement of glutamate binding and the kindling-induced learning deficit were examined." | 1.30 | Involvement of delta-opioid receptors in pentylenetetrazol kindling development and kindling-related processes in rats. ( Becker, A; Grecksch, G; Höllt, V; Schroeder, H, 1999) |
| "There was no effect on seizure outcome, whereas the learning deficit was ameliorated in the kindled group." | 1.29 | Naloxone ameliorates the learning deficit induced by pentylenetetrazol kindling in rats. ( Becker, A; Brosz, M; Grecksch, G, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (35.71) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Mahmoudi, T | 1 |
| Lorigooini, Z | 1 |
| Rafieian-Kopaei, M | 1 |
| Arabi, M | 1 |
| Rabiei, Z | 1 |
| Bijad, E | 1 |
| Kazemi, S | 1 |
| Zhao, RR | 1 |
| Xu, XC | 1 |
| Xu, F | 1 |
| Zhang, WL | 2 |
| Liu, LM | 1 |
| Wang, WP | 2 |
| Pourmotabbed, A | 1 |
| Mahmoodi, G | 1 |
| Mahmoodi, S | 1 |
| Mohammadi-Farani, A | 1 |
| Nedaei, SE | 1 |
| Pourmotabbed, T | 2 |
| Lee, Y | 1 |
| Kim, D | 1 |
| Kim, YH | 1 |
| Lee, H | 1 |
| Lee, CJ | 1 |
| Jia, LJ | 1 |
| Li, ZP | 1 |
| Zhen, JL | 1 |
| An, LW | 1 |
| Duan, RS | 1 |
| Stafstrom, CE | 1 |
| Sasaki-Adams, DM | 1 |
| Nagaraja, RY | 1 |
| Grecksch, G | 5 |
| Reymann, KG | 1 |
| Schroeder, H | 2 |
| Becker, A | 5 |
| Jia, F | 1 |
| Kato, M | 1 |
| Dai, H | 1 |
| Xu, A | 1 |
| Okuda, T | 1 |
| Sakurai, E | 1 |
| Okamura, N | 1 |
| Lovenberg, TW | 1 |
| Barbier, A | 1 |
| Carruthers, NI | 1 |
| Iinuma, K | 1 |
| Yanai, K | 1 |
| Brosz, M | 2 |
| Höllt, V | 1 |
| Rauca, C | 1 |
| Pohle, W | 1 |
| Grunenberg, K | 1 |
| Franze, S | 1 |
| Drago, F | 1 |
| Grassi, M | 1 |
| Valerio, C | 1 |
| Spadaro, F | 1 |
| D'Agata, V | 1 |
| Lauria, N | 1 |
14 other studies available for pentylenetetrazole and Learning Disabilities
| Article | Year |
|---|---|
Effect of Curcuma zedoaria hydro-alcoholic extract on learning, memory deficits and oxidative damage of brain tissue following seizures induced by pentylenetetrazole in rat.
Topics: Animals; Anticonvulsants; Antioxidants; Brain Chemistry; Convulsants; Curcuma; Flumazenil; GABA Modu | 2020 |
Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice.
Topics: Animals; Antioxidants; Brain; Convulsants; Glutathione; Kindling, Neurologic; Learning Disabilities; | 2014 |
Effect of central muscarinic receptors on passive-avoidance learning deficits induced by prenatal pentylenetetrazol kindling in male offspring.
Topics: Animals; Avoidance Learning; Brain; Female; Kindling, Neurologic; Learning Disabilities; Male; Musca | 2014 |
Improvement of pentylenetetrazol-induced learning deficits by valproic acid in the adult zebrafish.
Topics: Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Brain; Dose-Response Relationship, D | 2010 |
Memantine attenuates the impairment of spatial learning and memory of pentylenetetrazol-kindled rats.
Topics: Animals; Behavior, Animal; Convulsants; Excitatory Amino Acid Antagonists; Kindling, Neurologic; Lea | 2011 |
NMDA-induced seizures in developing rats cause long-term learning impairment and increased seizure susceptibility.
Topics: Animals; Animals, Newborn; Brain; Cognition Disorders; Convulsants; Electroencephalography; Excitato | 2003 |
Group I metabotropic glutamate receptors interfere in different ways with pentylenetetrazole seizures, kindling, and kindling-related learning deficits.
Topics: Animals; Avoidance Learning; Behavior, Animal; Benzoates; Binding Sites; Dose-Response Relationship, | 2004 |
Effects of histamine H(3) antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice.
Topics: Animals; Avoidance Learning; Convulsants; Donepezil; Electric Stimulation; Female; Histamine Antagon | 2006 |
Naloxone ameliorates the learning deficit induced by pentylenetetrazol kindling in rats.
Topics: Animals; Avoidance Learning; Dose-Response Relationship, Drug; Kindling, Neurologic; Learning Disabi | 1994 |
Antiepileptic drugs--their effects on kindled seizures and kindling-induced learning impairments.
Topics: Animals; Anticonvulsants; Avoidance Learning; Cognition; Dose-Response Relationship, Drug; Ethosuxim | 1995 |
Nootropic drugs have different effects on kindling-induced learning deficits in rats.
Topics: Animals; Avoidance Learning; Convulsants; Kindling, Neurologic; Learning; Learning Disabilities; Mal | 1995 |
Involvement of delta-opioid receptors in pentylenetetrazol kindling development and kindling-related processes in rats.
Topics: Animals; Convulsants; Drug Interactions; Glutamic Acid; Injections, Intraventricular; Kindling, Neur | 1999 |
Hypothermia inhibits pentylenetetrazol kindling and prevents kindling-induced deficit in shuttle-box avoidance.
Topics: Animals; Avoidance Learning; Body Temperature; Chlorpromazine; Cold Temperature; Corpus Striatum; Ki | 2000 |
Effects of vinburnine on experimental models of learning and memory impairments.
Topics: Amnesia, Retrograde; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Learning Dis | 1990 |