pentylenetetrazole has been researched along with Innate Inflammatory Response in 41 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we evaluated its neuroprotective effects at different doses (100 and 200 mg/kg) against pentylenetetrazole (PTZ)-induced seizures." | 8.31 | Neuroprotective effects of Royal Jelly (RJ) against pentylenetetrazole (PTZ)-induced seizures in rats by targeting inflammation and oxidative stress. ( Dolatshahi, M; Hashemi, P; Karimpour, S; Nazarinia, D, 2023) |
| " Here, we conducted present study to evaluate its neuroprotective effects against pentylenetetrazole (PTZ)-induced seizures in rats." | 8.31 | (-)-α-bisabolol exerts neuroprotective effects against pentylenetetrazole-induced seizures in rats by targeting inflammation and oxidative stress. ( Hashemi, P; Moslehi, A; Nazarinia, D, 2023) |
| " We investigated effects of long-term probiotics supplementation on epileptic seizures, and inflammatory and oxidant/antioxidant biomarkers in a pentylenetetrazole(PTZ)-induced seizure model in rats." | 8.02 | Protective effects of long-term probiotic mixture supplementation against pentylenetetrazole-induced seizures, inflammation and oxidative stress in rats. ( Ankarali, H; Ankarali, S; Ayhan, D; Cetinkaya, A; Kilinc, E; Torun, IE, 2021) |
| " Accordingly, the aim of this study is to determine if coenzyme Q10 (CoQ10) and alpha-tocopherol (α-Toc) have a neuroprotective effect in rats against the observed oxidative stress and inflammation during seizures induced by pentylenetetrazole (PTZ) in rats, and to study their interactions with the conventional antiseizure drug phenytoin (PHT), either alone or in combination." | 7.88 | Molecular mechanisms of neuroprotective effect of adjuvant therapy with phenytoin in pentylenetetrazole-induced seizures: Impact on Sirt1/NRF2 signaling pathways. ( Al-Khalek, HAA; Khalifa, AE; Masoud, SI; Nagib, MM; Rahmo, RM; Sabri, NA; Tadros, MG, 2018) |
| " Here, we found that gastrodin ameliorated pentylenetetrazole (PTZ)-induced epileptic seizures with improvement of the electroencephalographic pattern in mice." | 7.85 | Gastrodin Attenuates Pentylenetetrazole-Induced Seizures by Modulating the Mitogen-Activated Protein Kinase-Associated Inflammatory Responses in Mice. ( Chen, L; Liu, X; Qu, M; Wang, H, 2017) |
| "It has been demonstrated that the zebrafish model of pentylenetetrazole (PTZ)-evoked seizures and the well-established rodent models of epilepsy are similar pertaining to behavior, electrographic features, and c-fos expression." | 7.83 | Indomethacin treatment prior to pentylenetetrazole-induced seizures downregulates the expression of il1b and cox2 and decreases seizure-like behavior in zebrafish larvae. ( Barbalho, PG; Lopes-Cendes, I; Maurer-Morelli, CV, 2016) |
| "Eclampsia is characterized by high morbidity and mortality wordwide." | 5.51 | Magnesium sulfate attenuates brain edema by lowering AQP4 expression and inhibits glia-mediated neuroinflammation in a rodent model of eclampsia. ( Li, X; Liu, H; Yang, Y, 2019) |
| "The animals were assessed for seizure score, neuronal damage and inflammatory cytokines levels (IL-1β, IL-6 and TNF-α) in hippocampus." | 5.51 | Effect of dimethyl fumarate on neuroinflammation and apoptosis in pentylenetetrazol kindling model in rats. ( Banerjee, D; Bhatia, A; Chakrabarti, A; Kumari, P; Saha, L; Singh, J; Singh, N, 2019) |
| "Here, we hypothesized severe preeclampsia is a state of increased seizure susceptibility due to blood-brain barrier (BBB) disruption and neuroinflammation that lowers seizure threshold." | 5.40 | Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia. ( Chan, SL; Cipolla, MJ; Johnson, AC; LaMarca, B; Moseley, J; Nagle, KJ; Tremble, SM, 2014) |
| "Naringin is a bioflavonoid present in the grapefruit." | 5.40 | Naringin ameliorates pentylenetetrazol-induced seizures and associated oxidative stress, inflammation, and cognitive impairment in rats: possible mechanisms of neuroprotection. ( Arya, DS; Bhatia, J; Chaudhry, U; Golechha, M; Saluja, D; Sarangal, V, 2014) |
| " Here, we evaluated its neuroprotective effects at different doses (100 and 200 mg/kg) against pentylenetetrazole (PTZ)-induced seizures." | 4.31 | Neuroprotective effects of Royal Jelly (RJ) against pentylenetetrazole (PTZ)-induced seizures in rats by targeting inflammation and oxidative stress. ( Dolatshahi, M; Hashemi, P; Karimpour, S; Nazarinia, D, 2023) |
| " Here, we conducted present study to evaluate its neuroprotective effects against pentylenetetrazole (PTZ)-induced seizures in rats." | 4.31 | (-)-α-bisabolol exerts neuroprotective effects against pentylenetetrazole-induced seizures in rats by targeting inflammation and oxidative stress. ( Hashemi, P; Moslehi, A; Nazarinia, D, 2023) |
| " After 24 h, CCI-injured rats received intraperitoneal injection of pentylenetetrazole 35 mg/kg once every other day until acquisition of generalized seizures." | 4.12 | Activating toll-like receptor 4 after traumatic brain injury inhibits neuroinflammation and the accelerated development of seizures in rats. ( Choopani, S; Pourbadie, HG; Radpour, M; Sayyah, M, 2022) |
| " We investigated effects of long-term probiotics supplementation on epileptic seizures, and inflammatory and oxidant/antioxidant biomarkers in a pentylenetetrazole(PTZ)-induced seizure model in rats." | 4.02 | Protective effects of long-term probiotic mixture supplementation against pentylenetetrazole-induced seizures, inflammation and oxidative stress in rats. ( Ankarali, H; Ankarali, S; Ayhan, D; Cetinkaya, A; Kilinc, E; Torun, IE, 2021) |
| "We aimed to explore the effects of neuropeptides ghrelin, obestatin, and vasoactive intestinal peptide (VIP) on seizures and plasma concentrations of neuroinflammation biomarkers including calcitonin gene-related peptide (CGRP), substance-P (SP), and interleukin-1 beta (IL-1β) in pentylenetetrazol-induced seizures in rats." | 3.91 | Modulatory effects of neuropeptides on pentylenetetrazol-induced epileptic seizures and neuroinflammation in rats. ( Gunes, H; Kilinc, E, 2019) |
| " Accordingly, the aim of this study is to determine if coenzyme Q10 (CoQ10) and alpha-tocopherol (α-Toc) have a neuroprotective effect in rats against the observed oxidative stress and inflammation during seizures induced by pentylenetetrazole (PTZ) in rats, and to study their interactions with the conventional antiseizure drug phenytoin (PHT), either alone or in combination." | 3.88 | Molecular mechanisms of neuroprotective effect of adjuvant therapy with phenytoin in pentylenetetrazole-induced seizures: Impact on Sirt1/NRF2 signaling pathways. ( Al-Khalek, HAA; Khalifa, AE; Masoud, SI; Nagib, MM; Rahmo, RM; Sabri, NA; Tadros, MG, 2018) |
| " The role of MAC in oxidative stress and inflammation after pentylenetetrazole (PTZ)-induced kindling was investigated by measuring reactive oxygen species (ROS) production, superoxide dismutase (SOD), and catalase (CAT) activities, nitrite content, and deoxyribonucleic acid (DNA) damage in cerebral cortex." | 3.85 | Manual acupuncture improves parameters associated with oxidative stress and inflammation in PTZ-induced kindling in mice. ( Coelho, VR; da Silva, JB; da Silva, LL; de Souza, MS; Frantz, AL; Pereira, P; Pflüger, P; Picada, JN; Regner, GG; Saffi, J; Viau, CM, 2017) |
| " Here, we found that gastrodin ameliorated pentylenetetrazole (PTZ)-induced epileptic seizures with improvement of the electroencephalographic pattern in mice." | 3.85 | Gastrodin Attenuates Pentylenetetrazole-Induced Seizures by Modulating the Mitogen-Activated Protein Kinase-Associated Inflammatory Responses in Mice. ( Chen, L; Liu, X; Qu, M; Wang, H, 2017) |
| "It has been demonstrated that the zebrafish model of pentylenetetrazole (PTZ)-evoked seizures and the well-established rodent models of epilepsy are similar pertaining to behavior, electrographic features, and c-fos expression." | 3.83 | Indomethacin treatment prior to pentylenetetrazole-induced seizures downregulates the expression of il1b and cox2 and decreases seizure-like behavior in zebrafish larvae. ( Barbalho, PG; Lopes-Cendes, I; Maurer-Morelli, CV, 2016) |
| "The effect of methanolic extract of Asparagus pubescens was investigated on chemical, thermal-induced pain as well as fresh egg albumin-induced inflammation and pentylenetetrazol (PTZ)-induced convulsion in rodents." | 3.72 | Anti-nociceptive and anti-inflammatory effects of methanolic extract of Asparagus pubescens root in rodents. ( Nwafor, PA; Okwuasaba, FK, 2003) |
| "Inflammation is considered to be involved in epileptogenesis." | 1.91 | Inflammation as a target for the treatment of fever-associated epilepsy in zebrafish larvae. ( Liang, W; Shen, D; Shen, Y; Sui, J; Wang, J; Wu, Y; Yun, F; Zhang, Q; Zhou, J, 2023) |
| "Meanwhile, it decreased the seizure severity and reduced seizure-caused anxious behavior in the PTZ-kindling mice, suggesting a significant antiepileptic activity and anxiolytic/anxiogenic potential." | 1.91 | Herb pair of Polygala tenuifolia Willd and Acorus tatarinowii Schott decoction attenuates seizures and alleviates anxiety in mice: Evidence for modulating inflammation, alleviating oxidative stress and mediating GABA pathway. ( He, X; Liu, Y; Xie, Y; Yang, Y; Yuan, X, 2023) |
| "The treatment with sinigrin significantly delayed the appearance of the seizure symptoms in comparison to that of the PTZ group." | 1.72 | Preventive Effects of Sinigrin Against the Memory Deterioration in the Pentylenetetrazole-Kindled Male Wistar Rats: Possible Modulation of NLRP3 Pathway. ( Aghaie, F; Hosseini, A; Koneshlou, S; Moradifar, F; Rajabi, M, 2022) |
| "Seizures were induced in rats (postnatal day 10) by 5% O2 exposure for 15 min." | 1.62 | FTY720 administration following hypoxia-induced neonatal seizure reverse cognitive impairments and severity of seizures in male and female adult rats: The role of inflammation. ( Farbood, Y; Ghafouri, S; Najafian, SA; Sarkaki, A, 2021) |
| "Reversible posterior leukoencephalopathy syndrome (RPLS) is a clinical-imaging syndrome as well as a critical maternal complication." | 1.56 | Contribution of excess inflammation to a possible rat model of eclamptic reversible posterior leukoencephalopathy syndrome induced by lipopolysaccharide and pentylenetetrazol: A preliminary study. ( Chen, D; Fang, X; Liang, Y; Liu, Y; Xie, M; Zhang, W, 2020) |
| "Eclampsia is characterized by high morbidity and mortality wordwide." | 1.51 | Magnesium sulfate attenuates brain edema by lowering AQP4 expression and inhibits glia-mediated neuroinflammation in a rodent model of eclampsia. ( Li, X; Liu, H; Yang, Y, 2019) |
| "The animals were assessed for seizure score, neuronal damage and inflammatory cytokines levels (IL-1β, IL-6 and TNF-α) in hippocampus." | 1.51 | Effect of dimethyl fumarate on neuroinflammation and apoptosis in pentylenetetrazol kindling model in rats. ( Banerjee, D; Bhatia, A; Chakrabarti, A; Kumari, P; Saha, L; Singh, J; Singh, N, 2019) |
| "The median seizure stage, latency onset of first stage 4/5 seizures, and incidence of convulsing animals were recorded." | 1.46 | Octreotide ameliorates inflammation and apoptosis in acute and kindled murine PTZ paradigms. ( Al-Shorbagy, MY; Nassar, NN, 2017) |
| "Here, we hypothesized severe preeclampsia is a state of increased seizure susceptibility due to blood-brain barrier (BBB) disruption and neuroinflammation that lowers seizure threshold." | 1.40 | Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia. ( Chan, SL; Cipolla, MJ; Johnson, AC; LaMarca, B; Moseley, J; Nagle, KJ; Tremble, SM, 2014) |
| "Naringin is a bioflavonoid present in the grapefruit." | 1.40 | Naringin ameliorates pentylenetetrazol-induced seizures and associated oxidative stress, inflammation, and cognitive impairment in rats: possible mechanisms of neuroprotection. ( Arya, DS; Bhatia, J; Chaudhry, U; Golechha, M; Saluja, D; Sarangal, V, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.44) | 18.7374 |
| 1990's | 2 (4.88) | 18.2507 |
| 2000's | 2 (4.88) | 29.6817 |
| 2010's | 18 (43.90) | 24.3611 |
| 2020's | 18 (43.90) | 2.80 |
| Authors | Studies |
|---|---|
| Aghaie, F | 1 |
| Rajabi, M | 1 |
| Hosseini, A | 2 |
| Moradifar, F | 1 |
| Koneshlou, S | 1 |
| Wang, L | 2 |
| Ding, J | 1 |
| Zhu, C | 1 |
| Guo, B | 1 |
| Yang, W | 1 |
| He, W | 1 |
| Li, X | 2 |
| Wang, Y | 7 |
| Li, W | 1 |
| Wang, F | 1 |
| Sun, T | 1 |
| Radpour, M | 1 |
| Choopani, S | 1 |
| Pourbadie, HG | 1 |
| Sayyah, M | 1 |
| Khan, FA | 1 |
| Ali, G | 1 |
| Rahman, K | 1 |
| Khan, Y | 1 |
| Ayaz, M | 1 |
| Mosa, OF | 1 |
| Nawaz, A | 1 |
| Hassan, SSU | 1 |
| Bungau, S | 1 |
| Hu, Y | 3 |
| Meng, B | 3 |
| Yin, S | 3 |
| Yang, M | 3 |
| Li, Y | 3 |
| Liu, N | 3 |
| Li, S | 3 |
| Liu, Y | 5 |
| Sun, D | 3 |
| Wang, S | 3 |
| Fu, Z | 3 |
| Wu, Y | 4 |
| Pang, A | 3 |
| Sun, J | 3 |
| Yang, X | 4 |
| Ahlatcı, A | 1 |
| Yıldızhan, K | 1 |
| Tülüce, Y | 1 |
| Bektaş, M | 1 |
| Liang, W | 1 |
| Wang, J | 1 |
| Sui, J | 1 |
| Yun, F | 1 |
| Shen, Y | 1 |
| Zhou, J | 1 |
| Shen, D | 1 |
| Zhang, Q | 1 |
| Nazarinia, D | 2 |
| Karimpour, S | 1 |
| Hashemi, P | 2 |
| Dolatshahi, M | 1 |
| Ukwubile, CA | 1 |
| Ikpefan, EO | 1 |
| Dibal, MY | 1 |
| Umeano, VA | 1 |
| Menkiti, DN | 1 |
| Kaosi, CC | 1 |
| Paul, S | 1 |
| Famurewa, AC | 1 |
| Nettey, H | 1 |
| Yerima, TS | 1 |
| Xie, Y | 1 |
| Yang, Y | 2 |
| Yuan, X | 1 |
| He, X | 1 |
| Moslehi, A | 1 |
| Liu, Q | 1 |
| Yan, G | 1 |
| Zhang, W | 2 |
| Huan, Z | 1 |
| Li, J | 1 |
| Attia, GM | 1 |
| Elmansy, RA | 1 |
| Elsaed, WM | 1 |
| Kilinc, E | 2 |
| Gunes, H | 1 |
| Regner, GG | 2 |
| Torres, ILS | 1 |
| de Oliveira, C | 1 |
| Pflüger, P | 2 |
| da Silva, LS | 1 |
| Scarabelot, VL | 1 |
| Ströher, R | 1 |
| de Souza, A | 1 |
| Fregni, F | 1 |
| Pereira, P | 2 |
| Fang, X | 1 |
| Liang, Y | 1 |
| Chen, D | 1 |
| Xie, M | 1 |
| Sinha, P | 1 |
| Verma, B | 1 |
| Ganesh, S | 1 |
| Najafian, SA | 1 |
| Farbood, Y | 1 |
| Sarkaki, A | 1 |
| Ghafouri, S | 1 |
| Gomez, CD | 1 |
| Acharjee, S | 1 |
| Lewis, ML | 1 |
| Read, J | 1 |
| Pittman, QJ | 2 |
| Dang, J | 1 |
| Paudel, YN | 1 |
| Ren, Q | 1 |
| Zhang, S | 1 |
| Ji, X | 1 |
| Liu, K | 1 |
| Jin, M | 1 |
| Ankarali, S | 1 |
| Ayhan, D | 1 |
| Ankarali, H | 1 |
| Torun, IE | 1 |
| Cetinkaya, A | 1 |
| Temp, FR | 1 |
| Marafiga, JR | 1 |
| Milanesi, LH | 1 |
| Duarte, T | 1 |
| Rambo, LM | 1 |
| Pillat, MM | 1 |
| Mello, CF | 1 |
| Frantz, AL | 1 |
| Coelho, VR | 1 |
| da Silva, LL | 1 |
| Viau, CM | 1 |
| de Souza, MS | 1 |
| da Silva, JB | 1 |
| Picada, JN | 1 |
| Saffi, J | 1 |
| Liu, H | 1 |
| Huang, WY | 1 |
| Lin, S | 1 |
| Chen, HY | 1 |
| Chen, YP | 1 |
| Chen, TY | 1 |
| Hsu, KS | 1 |
| Wu, HM | 1 |
| Nagib, MM | 1 |
| Tadros, MG | 1 |
| Al-Khalek, HAA | 1 |
| Rahmo, RM | 1 |
| Sabri, NA | 1 |
| Khalifa, AE | 1 |
| Masoud, SI | 1 |
| Iqubal, A | 1 |
| Sharma, S | 1 |
| Sharma, K | 1 |
| Bhavsar, A | 1 |
| Hussain, I | 1 |
| Iqubal, MK | 1 |
| Kumar, R | 1 |
| Singh, N | 1 |
| Saha, L | 1 |
| Kumari, P | 1 |
| Singh, J | 1 |
| Bhatia, A | 1 |
| Banerjee, D | 1 |
| Chakrabarti, A | 1 |
| D'Mello, C | 1 |
| Riazi, K | 1 |
| Le, T | 1 |
| Stevens, KM | 1 |
| Wang, A | 1 |
| McKay, DM | 1 |
| Swain, MG | 1 |
| Aksoy, D | 1 |
| Solmaz, V | 1 |
| Taşkıran, D | 1 |
| Erbaş, O | 1 |
| Johnson, AC | 1 |
| Tremble, SM | 1 |
| Chan, SL | 1 |
| Moseley, J | 1 |
| LaMarca, B | 1 |
| Nagle, KJ | 1 |
| Cipolla, MJ | 1 |
| Golechha, M | 1 |
| Sarangal, V | 1 |
| Bhatia, J | 1 |
| Chaudhry, U | 1 |
| Saluja, D | 1 |
| Arya, DS | 1 |
| Johnson, MR | 1 |
| Behmoaras, J | 1 |
| Bottolo, L | 1 |
| Krishnan, ML | 1 |
| Pernhorst, K | 1 |
| Santoscoy, PLM | 1 |
| Rossetti, T | 1 |
| Speed, D | 1 |
| Srivastava, PK | 1 |
| Chadeau-Hyam, M | 1 |
| Hajji, N | 1 |
| Dabrowska, A | 1 |
| Rotival, M | 1 |
| Razzaghi, B | 1 |
| Kovac, S | 1 |
| Wanisch, K | 1 |
| Grillo, FW | 1 |
| Slaviero, A | 1 |
| Langley, SR | 1 |
| Shkura, K | 1 |
| Roncon, P | 1 |
| De, T | 1 |
| Mattheisen, M | 1 |
| Niehusmann, P | 1 |
| O'Brien, TJ | 1 |
| Petrovski, S | 1 |
| von Lehe, M | 1 |
| Hoffmann, P | 1 |
| Eriksson, J | 1 |
| Coffey, AJ | 1 |
| Cichon, S | 1 |
| Walker, M | 1 |
| Simonato, M | 1 |
| Danis, B | 1 |
| Mazzuferi, M | 1 |
| Foerch, P | 1 |
| Schoch, S | 1 |
| De Paola, V | 1 |
| Kaminski, RM | 1 |
| Cunliffe, VT | 1 |
| Becker, AJ | 1 |
| Petretto, E | 1 |
| Barbalho, PG | 1 |
| Lopes-Cendes, I | 1 |
| Maurer-Morelli, CV | 1 |
| Al-Shorbagy, MY | 1 |
| Nassar, NN | 1 |
| Chen, L | 1 |
| Liu, X | 1 |
| Wang, H | 1 |
| Qu, M | 1 |
| Nwafor, PA | 1 |
| Okwuasaba, FK | 1 |
| Petrillo, P | 1 |
| Angelici, O | 1 |
| Bingham, S | 1 |
| Ficalora, G | 1 |
| Garnier, M | 1 |
| Zaratin, PF | 1 |
| Petrone, G | 1 |
| Pozzi, O | 1 |
| Sbacchi, M | 1 |
| Stean, TO | 1 |
| Upton, N | 1 |
| Dondio, GM | 1 |
| Scheideler, MA | 1 |
| Li, YW | 1 |
| Zhu, XY | 1 |
| But, PP | 1 |
| Yeung, HW | 1 |
| Engelhardt, G | 1 |
| Bögel, R | 1 |
| Schnitzler, C | 1 |
| Utzmann, R | 1 |
| Karpiak, SE | 1 |
| Graf, L | 1 |
| Rapport, MM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Brain Activity and Oxygenation Using Near-infrared Spectroscopy (NIRS) in Inflammatory Bowel Disease (IBD) Patients[NCT04733456] | 40 participants (Anticipated) | Observational | 2021-04-26 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
41 other studies available for pentylenetetrazole and Innate Inflammatory Response
| Article | Year |
|---|---|
Preventive Effects of Sinigrin Against the Memory Deterioration in the Pentylenetetrazole-Kindled Male Wistar Rats: Possible Modulation of NLRP3 Pathway.
Topics: Animals; Epilepsy; Glucosinolates; Inflammation; Male; NLR Family, Pyrin Domain-Containing 3 Protein | 2022 |
Semaglutide attenuates seizure severity and ameliorates cognitive dysfunction by blocking the NLR family pyrin domain containing 3 inflammasome in pentylenetetrazole‑kindled mice.
Topics: Animals; Apoptosis; Cell Line; Cognitive Dysfunction; Cytokines; Disease Models, Animal; Epilepsy; G | 2021 |
Activating toll-like receptor 4 after traumatic brain injury inhibits neuroinflammation and the accelerated development of seizures in rats.
Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Inflammation; Interleukin-10; Neuroinfla | 2022 |
Efficacy of 2-Hydroxyflavanone in Rodent Models of Pain and Inflammation: Involvement of Opioidergic and GABAergic Anti-Nociceptive Mechanisms.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cisplatin; Disease Models, Animal; Edema; Flavanones; | 2022 |
Scorpion venom peptide HsTx2 suppressed PTZ-induced seizures in mice via the circ_0001293/miR-8114/TGF-β2 axis.
Topics: Animals; Inflammation; Mice; Mice, Inbred BALB C; MicroRNAs; NF-kappa B; Pentylenetetrazole; RNA, Ci | 2022 |
Scorpion venom peptide HsTx2 suppressed PTZ-induced seizures in mice via the circ_0001293/miR-8114/TGF-β2 axis.
Topics: Animals; Inflammation; Mice; Mice, Inbred BALB C; MicroRNAs; NF-kappa B; Pentylenetetrazole; RNA, Ci | 2022 |
Scorpion venom peptide HsTx2 suppressed PTZ-induced seizures in mice via the circ_0001293/miR-8114/TGF-β2 axis.
Topics: Animals; Inflammation; Mice; Mice, Inbred BALB C; MicroRNAs; NF-kappa B; Pentylenetetrazole; RNA, Ci | 2022 |
Scorpion venom peptide HsTx2 suppressed PTZ-induced seizures in mice via the circ_0001293/miR-8114/TGF-β2 axis.
Topics: Animals; Inflammation; Mice; Mice, Inbred BALB C; MicroRNAs; NF-kappa B; Pentylenetetrazole; RNA, Ci | 2022 |
Valproic Acid Attenuated PTZ-induced Oxidative Stress, Inflammation, and Apoptosis in the SH-SY5Y Cells via Modulating the TRPM2 Channel.
Topics: Apoptosis; Humans; Inflammation; Neuroblastoma; Oxidative Stress; Pentylenetetrazole; TRPM Cation Ch | 2022 |
Inflammation as a target for the treatment of fever-associated epilepsy in zebrafish larvae.
Topics: Animals; Disease Models, Animal; Epilepsy; Fever; Humans; Inflammation; Interleukin-1beta; Interleuk | 2023 |
Neuroprotective effects of Royal Jelly (RJ) against pentylenetetrazole (PTZ)-induced seizures in rats by targeting inflammation and oxidative stress.
Topics: Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Epilepsy; Inflammation; Male; Neurop | 2023 |
Pharmacognostic profiles, evaluation of analgesic, anti-inflammatory and anticonvulsant activities of Newbouldia laevis (P. Beauv.) Seem. ex Bureau leaf and root extracts in Wistar rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anticonvulsants; Edema; Inflammation; Methanol; Penty | 2023 |
Herb pair of Polygala tenuifolia Willd and Acorus tatarinowii Schott decoction attenuates seizures and alleviates anxiety in mice: Evidence for modulating inflammation, alleviating oxidative stress and mediating GABA pathway.
Topics: Acorus; Animals; Anticonvulsants; Anxiety; Epilepsy; gamma-Aminobutyric Acid; Inflammation; Mice; Ox | 2023 |
(-)-α-bisabolol exerts neuroprotective effects against pentylenetetrazole-induced seizures in rats by targeting inflammation and oxidative stress.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Inflammation; Male; Memory Disorders; Ne | 2023 |
MiR-125a-5p Alleviates Dysfunction and Inflammation of Pentylenetetrazol- induced Epilepsy Through Targeting Calmodulin-dependent Protein Kinase IV (CAMK4).
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Cell Proliferation; Down-Regulation; In | 2019 |
Neuroprotective effect of nilotinib on pentylenetetrazol-induced epilepsy in adult rat hippocampus: involvement of oxidative stress, autophagy, inflammation, and apoptosis.
Topics: Animals; Apoptosis; Autophagy; Epilepsy; Hippocampus; Inflammation; Male; Neuroprotective Agents; Ox | 2019 |
Modulatory effects of neuropeptides on pentylenetetrazol-induced epileptic seizures and neuroinflammation in rats.
Topics: Animals; Biomarkers; Calcitonin Gene-Related Peptide; Convulsants; Disease Models, Animal; Ghrelin; | 2019 |
Transcranial direct current stimulation (tDCS) affects neuroinflammation parameters and behavioral seizure activity in pentylenetetrazole-induced kindling in rats.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Inflammation; Kindling, Neurologic; Male; Pe | 2020 |
Contribution of excess inflammation to a possible rat model of eclamptic reversible posterior leukoencephalopathy syndrome induced by lipopolysaccharide and pentylenetetrazol: A preliminary study.
Topics: Animals; Astrocytes; Blood Pressure; Blood-Brain Barrier; Brain; Disease Models, Animal; Eclampsia; | 2020 |
Trehalose Ameliorates Seizure Susceptibility in Lafora Disease Mouse Models by Suppressing Neuroinflammation and Endoplasmic Reticulum Stress.
Topics: Animals; Autophagy; Brain; Calcium-Binding Proteins; Disease Models, Animal; Disease Susceptibility; | 2021 |
FTY720 administration following hypoxia-induced neonatal seizure reverse cognitive impairments and severity of seizures in male and female adult rats: The role of inflammation.
Topics: Aging; Animals; Animals, Newborn; Cognitive Dysfunction; Epilepsy; Female; Fingolimod Hydrochloride; | 2021 |
Increased Excitatory Synaptic Transmission Associated with Adult Seizure Vulnerability Induced by Early-Life Inflammation in Mice.
Topics: Animals; Convulsants; Excitatory Postsynaptic Potentials; Female; Hippocampus; Inflammation; Lipopol | 2021 |
Schaftoside Suppresses Pentylenetetrazol-Induced Seizures in Zebrafish via Suppressing Apoptosis, Modulating Inflammation, and Oxidative Stress.
Topics: Animals; Apoptosis; Glycosides; Inflammation; Oxidative Stress; Pentylenetetrazole; Seizures; Zebraf | 2021 |
Protective effects of long-term probiotic mixture supplementation against pentylenetetrazole-induced seizures, inflammation and oxidative stress in rats.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Convulsants; Cytokines; Disease Models, Animal; Epile | 2021 |
Cyclooxygenase-2 inhibitors differentially attenuate pentylenetetrazol-induced seizures and increase of pro- and anti-inflammatory cytokine levels in the cerebral cortex and hippocampus of mice.
Topics: Animals; Cerebral Cortex; Cyclooxygenase 2 Inhibitors; Cytokines; Hippocampus; Inflammation; Male; M | 2017 |
Manual acupuncture improves parameters associated with oxidative stress and inflammation in PTZ-induced kindling in mice.
Topics: Acupuncture Therapy; Animals; Anticonvulsants; Antioxidants; Convulsants; Disease Models, Animal; In | 2017 |
Magnesium sulfate attenuates brain edema by lowering AQP4 expression and inhibits glia-mediated neuroinflammation in a rodent model of eclampsia.
Topics: Animals; Aquaporin 4; Astrocytes; Brain Edema; CA3 Region, Hippocampal; Cytokines; Disease Models, A | 2019 |
NADPH oxidases as potential pharmacological targets against increased seizure susceptibility after systemic inflammation.
Topics: Animals; Cells, Cultured; Drug Delivery Systems; Enzyme Inhibitors; Inflammation; Lipopolysaccharide | 2018 |
Molecular mechanisms of neuroprotective effect of adjuvant therapy with phenytoin in pentylenetetrazole-induced seizures: Impact on Sirt1/NRF2 signaling pathways.
Topics: alpha-Tocopherol; Animals; Anticonvulsants; Antioxidants; Brain; Inflammation; Male; Neurons; Neurop | 2018 |
Intranasally administered pitavastatin ameliorates pentylenetetrazol-induced neuroinflammation, oxidative stress and cognitive dysfunction.
Topics: Administration, Intranasal; Animals; Behavior, Animal; Cognitive Dysfunction; Convulsants; Hydroxyme | 2018 |
Effect of dimethyl fumarate on neuroinflammation and apoptosis in pentylenetetrazol kindling model in rats.
Topics: Animals; Apoptosis; Dimethyl Fumarate; Disease Models, Animal; Epilepsy; Hippocampus; Inflammation; | 2019 |
P-selectin-mediated monocyte-cerebral endothelium adhesive interactions link peripheral organ inflammation to sickness behaviors.
Topics: Alanine Transaminase; Animals; Cell Adhesion; Cerebral Cortex; Cholestasis; Colitis; Cytokines; Dini | 2013 |
The association between seizure predisposition and inflammation in a rat model of fatty liver disease.
Topics: Animals; Brain; Convulsants; Disease Susceptibility; Electroencephalography; Fatty Liver; Fructose; | 2014 |
Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Convulsants; Diet, High-Fat; Disease Models, Anima | 2014 |
Naringin ameliorates pentylenetetrazol-induced seizures and associated oxidative stress, inflammation, and cognitive impairment in rats: possible mechanisms of neuroprotection.
Topics: Animals; Cognition Disorders; Convulsants; Flavanones; Inflammation; Neuroprotective Agents; Oxidati | 2014 |
Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus.
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Epilepsy, Temporal Lobe; Female; Gene Regulator | 2015 |
Indomethacin treatment prior to pentylenetetrazole-induced seizures downregulates the expression of il1b and cox2 and decreases seizure-like behavior in zebrafish larvae.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclooxygenase 2; Disease Models, Animal; D | 2016 |
Octreotide ameliorates inflammation and apoptosis in acute and kindled murine PTZ paradigms.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Apoptosis; Caspase 3; Cerebral Cortex; Cytoprote | 2017 |
Gastrodin Attenuates Pentylenetetrazole-Induced Seizures by Modulating the Mitogen-Activated Protein Kinase-Associated Inflammatory Responses in Mice.
Topics: Animals; Anti-Inflammatory Agents; Benzyl Alcohols; Convulsants; CREB-Binding Protein; Disease Model | 2017 |
Anti-nociceptive and anti-inflammatory effects of methanolic extract of Asparagus pubescens root in rodents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Behavior | 2003 |
Evidence for a selective role of the delta-opioid agonist [8R-(4bS*,8aalpha,8abeta, 12bbeta)]7,10-Dimethyl-1-methoxy-11-(2-methylpropyl)oxycarbonyl 5,6,7,8,12,12b-hexahydro-(9H)-4,8-methanobenzofuro[3,2-e]pyrrolo[2,3-g]isoquinoline hydrochloride (SB-23586
Topics: Animals; Binding, Competitive; Carrageenan; Cells, Cultured; Convulsants; Cyclic AMP; Electroshock; | 2003 |
Ethnopharmacology of bear gall bladder: I.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anticonvulsants; Bile; Bile Ac | 1995 |
Meloxicam: influence on arachidonic acid metabolism. Part II. In vivo findings.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Brain; Con | 1996 |
Antiserum to brain gangliosides produces recurrent epileptiform activity.
Topics: Action Potentials; Animals; Antibodies; Antigen-Antibody Reactions; Brain; Edema; Gangliosides; Infl | 1976 |