pentylenetetrazole has been researched along with Hypothermia in 12 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Hypothermia: Lower than normal body temperature, especially in warm-blooded animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the current study the link among the γ-hydroxybutyrate (GHB)/pentylenetetrazole (PTZ)-induced absence-like seizures and concomitant decreases in the core temperature, as well as electroencephalographic (EEG) activity during rewarming from deep hypothermia produced by a drug-free protocol were investigated." | 3.79 | GABAB receptors as a common target for hypothermia and spike and wave seizures: intersecting mechanisms of thermoregulation and absence epilepsy. ( Andjus, PR; Ilić, TV; Ostojić, ZS; Vesković, SM, 2013) |
| " Bicuculline increases GABA-induced hypothermia, does not modify DAVA (250 mg/kg) and VPA (100 and 400 mg/kg) hypothermia and antagonizes initial hypothermia by DAVA (1000 mg/kg) and VPA (200 mg/kg) and late hypothermia by DAVA (500 mg/kg) and VPA (200 mg/kg)." | 3.67 | Involvement of bicuculline-insensitive receptors in the hypothermic effect of GABA and its agonists. ( Durán, JA; Miñano, FJ; Sancibrián, M; Serrano, JS, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ostojić, ZS | 1 |
| Ilić, TV | 1 |
| Vesković, SM | 1 |
| Andjus, PR | 1 |
| PRESL, J | 1 |
| KLETECKA, P | 1 |
| ASKEW, BM | 1 |
| COSTAL, M | 1 |
| AUSMAN, J | 1 |
| WOLDRING, S | 1 |
| OWENS, G | 1 |
| METYSOVA, J | 1 |
| METYS, J | 1 |
| Chandra, D | 1 |
| Werner, DF | 1 |
| Liang, J | 1 |
| Suryanarayanan, A | 1 |
| Harrison, NL | 1 |
| Spigelman, I | 1 |
| Olsen, RW | 1 |
| Homanics, GE | 1 |
| Bruins Slot, LA | 1 |
| Tarayre, JP | 1 |
| Koek, W | 1 |
| Ribet, JP | 1 |
| Colpaert, FC | 1 |
| Ritzmann, RF | 1 |
| Tabakoff, B | 1 |
| Serrano, JS | 1 |
| Miñano, FJ | 1 |
| Sancibrián, M | 1 |
| Durán, JA | 1 |
| Suchowsky, GK | 2 |
| Pegrassi, L | 2 |
| Ratcliffe, F | 1 |
| Bernardi, L | 1 |
| Coda, S | 1 |
| Bonsignori, A | 1 |
12 other studies available for pentylenetetrazole and Hypothermia
| Article | Year |
|---|---|
GABAB receptors as a common target for hypothermia and spike and wave seizures: intersecting mechanisms of thermoregulation and absence epilepsy.
Topics: Animals; Anticonvulsants; Benzoates; Body Temperature Regulation; Cerebral Cortex; Diazepam; Epileps | 2013 |
[Hypothermia following the administration of pentamethylenetetrazole and cerebrocortical oxygen requirement].
Topics: Body Temperature; Cerebral Cortex; Hypothermia; Oxygen; Pentylenetetrazole; Pharmaceutical Preparati | 1959 |
A SIMPLE SCREENING PROCEDURE FOR IMIPRAMINE-LIKE ANTIDEPRESSANT AGENTS.
Topics: 5-Hydroxytryptophan; Amitriptyline; Amphetamine; Amphetamines; Antidepressive Agents; Atropine; Beme | 1963 |
MONOVENTRICULAR HYPOTHERMIC PERFUSION. CORTICAL ELECTRIC RESPONSES TO ANALEPTIC AGENTS.
Topics: Animals; Bemegride; Brain; Central Nervous System Stimulants; Cerebral Cortex; Cerebral Ventricles; | 1963 |
PHARMACOLOGICAL PROPERTIES OF THE DESMETHYL DERIVATIVES OF SOME ANTIDEPRESSANTS OF IMIPRAMINE TYPE.
Topics: Amitriptyline; Animals; Antidepressive Agents; Caffeine; Desipramine; Hypothermia; Hypothermia, Indu | 1965 |
Normal acute behavioral responses to moderate/high dose ethanol in GABAA receptor alpha 4 subunit knockout mice.
Topics: Animals; Behavior, Animal; Central Nervous System Depressants; Ethanol; Female; GABA-A Receptor Anta | 2008 |
Experimental conditions for the continuous subcutaneous infusion of four central analgesics in rats.
Topics: Acetates; Amines; Analgesics; Anesthetics, Dissociative; Animals; Anticonvulsants; Antidepressive Ag | 2002 |
Dissociation of alcohol tolerance and dependence.
Topics: Alcoholic Intoxication; Animals; Drug Tolerance; Humans; Hydroxydopamines; Hypothermia; Male; Mice; | 1976 |
Involvement of bicuculline-insensitive receptors in the hypothermic effect of GABA and its agonists.
Topics: Amino Acids; Amino Acids, Neutral; Animals; Bicuculline; Body Temperature; Drug Interactions; Female | 1985 |
The pharmacology of 4H-3-methylcarboxyamide-1,3-benzoxazine-2-one (F.I. 6654), a compound acting on the central nervous system.
Topics: Anesthesia; Animals; Atropine; Barbiturates; Behavior, Animal; Cats; Central Nervous System; Depress | 1969 |
The effect of mescaline and bufotenine on some central actions of noradrenaline.
Topics: Amobarbital; Animals; Body Temperature; Central Nervous System; Depression, Chemical; Drug Antagonis | 1971 |
Central depressant properties of 3,1-benzoxazine derivates.
Topics: Animals; Central Nervous System; Depression, Chemical; Electroshock; Hypothermia; Male; Mice; Nicoti | 1969 |