pentylenetetrazole has been researched along with Genetic Predisposition in 30 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seizures were induced with pentylenetetrazole (PTZ)." | 3.74 | A large-scale mutagenesis screen to identify seizure-resistant zebrafish. ( Baraban, SC; Castro, PA; Chege, S; Dinday, MT; Guyenet, S; Taylor, MR, 2007) |
| "Seizures were induced by intraperitoneal administration of pentylenetetrazol (PTZ), picrotoxin (PIC), or kainic acid (KA) respectively." | 3.72 | Increase in drug-induced seizure susceptibility of transgenic mice overexpressing GABA transporter-1. ( Fei, J; Guo, LH; Ma, YH; Mei, ZT; Zhao, WJ, 2003) |
| " ZnT3-/- mice, which lack histochemically reactive zinc in synaptic vesicles, had slightly higher thresholds to seizures elicited by the GABA(A) antagonist, bicuculline, and no differences in seizure threshold were seen in response to pentylenetetrazol or flurothyl." | 3.70 | Seizures and neuronal damage in mice lacking vesicular zinc. ( Cole, TB; Palmiter, RD; Robbins, CA; Schwartzkroin, PA; Wenzel, HJ, 2000) |
| "In the NE-100-induced seizure model, Sig1R-/- animals demonstrated lower seizure scores, shorter durations and increased latency times of seizures compared to WT mice." | 1.62 | Genetic inactivation of the sigma-1 chaperone protein results in decreased expression of the R2 subunit of the GABA-B receptor and increased susceptibility to seizures. ( Dambrova, M; Kupats, E; Lauberte, L; Mezapuke, R; Stelfa, G; Svalbe, B; Vavers, E; Vilks, K; Zvejniece, B; Zvejniece, L, 2021) |
| "Unregulated neuro-inflammation mediates seizures in temporal lobe epilepsy (TLE)." | 1.62 | Downregulation of CD40L-CD40 attenuates seizure susceptibility and severity of seizures. ( Anderson, T; Borenstein, R; Howard, K; Major, CK; Musto, AE; Ojeda, A; Pototskiy, E; Sharma, D; Vinokuroff, K, 2021) |
| "New mouse models of epilepsy are needed to better understand the complex genetic architecture of seizures and to identify therapeutics." | 1.56 | Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility. ( Bell, TA; Dalton, KA; Gu, B; Hock, P; Miller, DR; Pan, Y; Pardo-Manuel de Villena, F; Philpot, BD; Shaw, GD; Shorter, JR; Williams, LH, 2020) |
| "The enhanced seizure susceptibility of the NaV1." | 1.42 | 'Neonatal' Nav1.2 reduces neuronal excitability and affects seizure susceptibility and behaviour. ( Aumann, TD; Churilov, L; Featherby, TJ; Gazina, EV; Hammond, VE; Kim, TH; Leaw, BT; Petrou, S; Reid, CA; Richards, KL; Wimmer, VC, 2015) |
| " Susceptibility to absence seizures was examined by analysing the frequency and duration of spike-and-wave discharge (SWD) events and accompanying motor seizure activity induced by subcutaneous administration of low dosage (20 or 30mg/kg) PTZ." | 1.42 | Reduced susceptibility to induced seizures in the Neuroligin-3(R451C) mouse model of autism. ( Anderson, P; Argyropoulos, A; Hannan, AJ; Hill-Yardin, EL; Hosie, S; O'Brien, TJ; Rind, G, 2015) |
| "In addition, convulsive seizure activity was induced by systemic administration of either 4-aminopyridine (4-AP; 10 mg/kg, i." | 1.33 | Altered seizure susceptibility in mice lacking the Ca(v)2.3 E-type Ca2+ channel. ( Henry, M; Hescheler, J; Kamp, M; Krieger, A; Radhakrishnan, K; Schneider, T; Weiergräber, M, 2006) |
| "increases seizure susceptibility." | 1.32 | Continuous increase of epileptogenic effects following application of proteolytic enzymes (buccal ganglia of Helix pomatia). ( Altrup, U; Joschko, A; Ure, A, 2004) |
| "Epilepsy is one of the most common but genetically complex neurological disorders in humans." | 1.32 | Genetic and phenotypic analysis of seizure susceptibility in PL/J mice. ( Ernest, S; Frankel, WN; Friedman, L; Gallaugher, L; Kitami, T; Nadeau, JH, 2004) |
| "In general, DBH KO mice were much more seizure-sensitive than NPY KO mice and had normal NPY expression, demonstrating that an NPY deficiency did not contribute to the DBH KO seizure phenotype." | 1.31 | Genetic comparison of seizure control by norepinephrine and neuropeptide Y. ( Hohmann, JG; Miller, NS; Palmiter, RD; Pyati, U; Rust, NC; Szot, P; Weinshenker, D; White, SS, 2001) |
| "PTZ-induced seizures were inhibited by three standard anticonvulsant drugs, but not by the group III selective mGluR agonist (R,S)-4-phosphonophenylglycine (PPG)." | 1.31 | Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7. ( Burnashev, N; Bushell, TJ; Clarke, VR; Collett, VJ; Collingridge, GL; Duvoisin, RM; Flor, PJ; Gasparini, F; Hampson, DR; Klebs, K; Knoepfel, T; Kuhn, R; Portet, C; Rozov, A; Sansig, G; Schmutz, M; Schroeder, M; Shigemoto, R; van Der Putten, H; Zhang, C, 2001) |
| "F2 intercross progeny, derived from seizure-sensitive DBA/2J (D2) and seizure-resistant C57BL/6J (B6) inbred strains of mice, were tested for their sensitivity to the seizure-inducing effect of pentylenetetrazol (PTZ), a gamma-aminobutyric acid (GABA) receptor antagonist." | 1.30 | Genotyping microsatellite polymorphisms by agarose gel electrophoresis with ethidium bromide staining: application to quantitative trait loci analysis of seizure susceptibility in mice. ( Ballas, C; Berrettini, WH; Buono, RJ; Ferraro, TN; Golden, GT; Mulholland, N; Schill, JF; Smith, GG, 1998) |
| "Latencies were used to calculate a seizure score that was used for quantitative mapping." | 1.30 | Mapping loci for pentylenetetrazol-induced seizure susceptibility in mice. ( Ballas, C; Berrettini, WH; Buono, RJ; Ferraro, TN; Golden, GT; Mulholland, N; Schill, J; Schork, NJ; Smith, GG; St Jean, P, 1999) |
| "In conclusion, the results confirm a genetic susceptibility in GAERS and/or resistance in inbred non-epileptic rats to focal and generalized seizures involving the cortex." | 1.30 | Susceptibility to focal and generalized seizures in Wistar rats with genetic absence-like epilepsy. ( Boehrer, A; Brailowsky, S; Marescaux, C; Montiel, T; Vergnes, M, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (10.00) | 18.2507 |
| 2000's | 19 (63.33) | 29.6817 |
| 2010's | 4 (13.33) | 24.3611 |
| 2020's | 4 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Chmielewska, N | 1 |
| Wawer, A | 1 |
| Maciejak, P | 1 |
| Turzyńska, D | 1 |
| Sobolewska, A | 1 |
| Skórzewska, A | 1 |
| Osuch, B | 1 |
| Płaźnik, A | 1 |
| Szyndler, J | 1 |
| Gu, B | 1 |
| Shorter, JR | 1 |
| Williams, LH | 1 |
| Bell, TA | 1 |
| Hock, P | 1 |
| Dalton, KA | 1 |
| Pan, Y | 1 |
| Miller, DR | 1 |
| Shaw, GD | 1 |
| Philpot, BD | 1 |
| Pardo-Manuel de Villena, F | 1 |
| Vavers, E | 1 |
| Zvejniece, B | 1 |
| Stelfa, G | 1 |
| Svalbe, B | 1 |
| Vilks, K | 1 |
| Kupats, E | 1 |
| Mezapuke, R | 1 |
| Lauberte, L | 1 |
| Dambrova, M | 1 |
| Zvejniece, L | 1 |
| Pototskiy, E | 1 |
| Vinokuroff, K | 1 |
| Ojeda, A | 1 |
| Major, CK | 1 |
| Sharma, D | 1 |
| Anderson, T | 1 |
| Howard, K | 1 |
| Borenstein, R | 1 |
| Musto, AE | 1 |
| Gazina, EV | 1 |
| Leaw, BT | 1 |
| Richards, KL | 1 |
| Wimmer, VC | 1 |
| Kim, TH | 1 |
| Aumann, TD | 1 |
| Featherby, TJ | 1 |
| Churilov, L | 1 |
| Hammond, VE | 1 |
| Reid, CA | 2 |
| Petrou, S | 2 |
| Hill-Yardin, EL | 1 |
| Argyropoulos, A | 1 |
| Hosie, S | 1 |
| Rind, G | 1 |
| Anderson, P | 1 |
| Hannan, AJ | 1 |
| O'Brien, TJ | 1 |
| Zhang, CS | 1 |
| Bertaso, F | 1 |
| Eulenburg, V | 1 |
| Lerner-Natoli, M | 1 |
| Herin, GA | 1 |
| Bauer, L | 1 |
| Bockaert, J | 1 |
| Fagni, L | 1 |
| Betz, H | 1 |
| Scheschonka, A | 1 |
| Chiu, C | 1 |
| Tan, HO | 1 |
| Davies, PJ | 1 |
| Single, FN | 1 |
| Koukoulas, I | 1 |
| Berkovic, SF | 1 |
| Tan, SS | 1 |
| Sprengel, R | 1 |
| Jones, MV | 1 |
| Gililland-Kaufman, KR | 1 |
| Tanchuck, MA | 1 |
| Ford, MM | 1 |
| Crabbe, JC | 1 |
| Beadles-Bohling, AS | 1 |
| Snelling, C | 1 |
| Mark, GP | 1 |
| Finn, DA | 1 |
| Xiong, H | 1 |
| Xia, K | 1 |
| Li, B | 1 |
| Zhao, G | 1 |
| Zhang, Z | 1 |
| Loyens, E | 1 |
| Schallier, A | 1 |
| Chai, SY | 1 |
| De Bundel, D | 1 |
| Vanderheyden, P | 1 |
| Michotte, Y | 1 |
| Smolders, I | 1 |
| Harai, T | 1 |
| Inoue, R | 1 |
| Fujita, Y | 1 |
| Tanaka, A | 1 |
| Horio, M | 1 |
| Hashimoto, K | 1 |
| Hongou, K | 1 |
| Miyawaki, T | 1 |
| Mori, H | 1 |
| Zhao, WJ | 1 |
| Ma, YH | 1 |
| Fei, J | 1 |
| Mei, ZT | 1 |
| Guo, LH | 1 |
| Binder, DK | 1 |
| Oshio, K | 1 |
| Ma, T | 1 |
| Verkman, AS | 1 |
| Manley, GT | 1 |
| Schwaller, B | 1 |
| Tetko, IV | 1 |
| Tandon, P | 1 |
| Silveira, DC | 1 |
| Vreugdenhil, M | 1 |
| Henzi, T | 1 |
| Potier, MC | 1 |
| Celio, MR | 1 |
| Villa, AE | 1 |
| Altrup, U | 1 |
| Ure, A | 1 |
| Joschko, A | 1 |
| De Sarro, G | 1 |
| Ibbadu, GF | 1 |
| Marra, R | 1 |
| Rotiroti, D | 1 |
| Loiacono, A | 1 |
| Donato Di Paola, E | 1 |
| Russo, E | 1 |
| Kitami, T | 1 |
| Ernest, S | 1 |
| Gallaugher, L | 1 |
| Friedman, L | 1 |
| Frankel, WN | 1 |
| Nadeau, JH | 1 |
| Ateş, N | 1 |
| Akman, O | 1 |
| Karson, A | 1 |
| Weiergräber, M | 1 |
| Henry, M | 1 |
| Krieger, A | 1 |
| Kamp, M | 1 |
| Radhakrishnan, K | 1 |
| Hescheler, J | 1 |
| Schneider, T | 1 |
| Baraban, SC | 1 |
| Dinday, MT | 1 |
| Castro, PA | 1 |
| Chege, S | 1 |
| Guyenet, S | 1 |
| Taylor, MR | 1 |
| Chaix, Y | 1 |
| Ferraro, TN | 3 |
| Lapouble, E | 1 |
| Martin, B | 1 |
| van Gassen, KL | 1 |
| Hessel, EV | 1 |
| Ramakers, GM | 1 |
| Notenboom, RG | 1 |
| Wolterink-Donselaar, IG | 1 |
| Brakkee, JH | 1 |
| Godschalk, TC | 1 |
| Qiao, X | 1 |
| Spruijt, BM | 1 |
| van Nieuwenhuizen, O | 1 |
| de Graan, PN | 1 |
| Schill, JF | 1 |
| Ballas, C | 2 |
| Mulholland, N | 2 |
| Golden, GT | 2 |
| Smith, GG | 2 |
| Buono, RJ | 2 |
| Berrettini, WH | 2 |
| St Jean, P | 1 |
| Schork, NJ | 1 |
| Schill, J | 1 |
| Brailowsky, S | 1 |
| Montiel, T | 1 |
| Boehrer, A | 1 |
| Marescaux, C | 1 |
| Vergnes, M | 1 |
| Cole, TB | 1 |
| Robbins, CA | 1 |
| Wenzel, HJ | 1 |
| Schwartzkroin, PA | 1 |
| Palmiter, RD | 2 |
| Weinshenker, D | 1 |
| Szot, P | 1 |
| Miller, NS | 1 |
| Rust, NC | 1 |
| Hohmann, JG | 1 |
| Pyati, U | 1 |
| White, SS | 1 |
| Sansig, G | 1 |
| Bushell, TJ | 1 |
| Clarke, VR | 1 |
| Rozov, A | 1 |
| Burnashev, N | 1 |
| Portet, C | 1 |
| Gasparini, F | 1 |
| Schmutz, M | 1 |
| Klebs, K | 1 |
| Shigemoto, R | 1 |
| Flor, PJ | 1 |
| Kuhn, R | 1 |
| Knoepfel, T | 1 |
| Schroeder, M | 1 |
| Hampson, DR | 1 |
| Collett, VJ | 1 |
| Zhang, C | 1 |
| Duvoisin, RM | 1 |
| Collingridge, GL | 1 |
| van Der Putten, H | 1 |
| Cao, BJ | 1 |
| Li, Y | 1 |
1 review available for pentylenetetrazole and Genetic Predisposition
| Article | Year |
|---|---|
Chemoconvulsant-induced seizure susceptibility: toward a common genetic basis?
Topics: Animals; Carbolines; Chromosome Mapping; Chromosomes; Convulsants; GABA Agonists; Genetic Predisposi | 2007 |
29 other studies available for pentylenetetrazole and Genetic Predisposition
| Article | Year |
|---|---|
The role of REST/NRSF, TrkB and BDNF in neurobiological mechanisms of different susceptibility to seizure in a PTZ model of epilepsy.
Topics: Animals; Brain-Derived Neurotrophic Factor; Epilepsy; Genetic Predisposition to Disease; Male; Penty | 2020 |
Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility.
Topics: Animals; Chromosome Mapping; Collaborative Cross Mice; Convulsants; Disease Models, Animal; Epilepsy | 2020 |
Genetic inactivation of the sigma-1 chaperone protein results in decreased expression of the R2 subunit of the GABA-B receptor and increased susceptibility to seizures.
Topics: Animals; Anisoles; Bicuculline; Convulsants; Gene Expression; Genetic Predisposition to Disease; Hab | 2021 |
Downregulation of CD40L-CD40 attenuates seizure susceptibility and severity of seizures.
Topics: Animals; CD40 Antigens; CD40 Ligand; Disease Models, Animal; Down-Regulation; Epilepsy, Temporal Lob | 2021 |
'Neonatal' Nav1.2 reduces neuronal excitability and affects seizure susceptibility and behaviour.
Topics: Action Potentials; Alternative Splicing; Animals; Animals, Newborn; Behavior, Animal; Brain; Disease | 2015 |
Reduced susceptibility to induced seizures in the Neuroligin-3(R451C) mouse model of autism.
Topics: Animals; Cell Adhesion Molecules, Neuronal; Child Development Disorders, Pervasive; Dose-Response Re | 2015 |
Knock-in mice lacking the PDZ-ligand motif of mGluR7a show impaired PKC-dependent autoinhibition of glutamate release, spatial working memory deficits, and increased susceptibility to pentylenetetrazol.
Topics: Amino Acid Motifs; Animals; Behavior, Animal; Brain; Carrier Proteins; Cell Cycle Proteins; Cells, C | 2008 |
Developmental impact of a familial GABAA receptor epilepsy mutation.
Topics: Animals; Brain; Brain Chemistry; Convulsants; Disease Models, Animal; Epilepsy; gamma-Aminobutyric A | 2008 |
The neurosteroid environment in the hippocampus exerts bi-directional effects on seizure susceptibility in mice.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Alcohol-Induced Disorders, Nerv | 2008 |
KChIP1: a potential modulator to GABAergic system.
Topics: Animals; Brain; Female; GABA Antagonists; Gene Expression Profiling; Genetic Predisposition to Disea | 2009 |
Deletion of insulin-regulated aminopeptidase in mice decreases susceptibility to pentylenetetrazol-induced generalized seizures.
Topics: Animals; Cystinyl Aminopeptidase; Gene Deletion; Genetic Predisposition to Disease; Male; Mice; Mice | 2011 |
Decreased susceptibility to seizures induced by pentylenetetrazole in serine racemase knockout mice.
Topics: Amino Acids; Analysis of Variance; Animals; Brain; Chromatography, High Pressure Liquid; Convulsants | 2012 |
Increase in drug-induced seizure susceptibility of transgenic mice overexpressing GABA transporter-1.
Topics: Animals; Animals, Genetically Modified; Anticonvulsants; Carrier Proteins; Disease Models, Animal; F | 2003 |
Increased seizure threshold in mice lacking aquaporin-4 water channels.
Topics: Action Potentials; Animals; Aquaporin 4; Aquaporins; Brain; Brain Edema; Convulsants; Disease Models | 2004 |
Parvalbumin deficiency affects network properties resulting in increased susceptibility to epileptic seizures.
Topics: Action Potentials; Animals; Brain; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Geneti | 2004 |
Continuous increase of epileptogenic effects following application of proteolytic enzymes (buccal ganglia of Helix pomatia).
Topics: Animals; Biological Clocks; Cheek; Convulsants; Disease Models, Animal; Enzymes; Epilepsy; Ganglia, | 2004 |
Seizure susceptibility to various convulsant stimuli in dystrophin-deficient mdx mice.
Topics: Acute Disease; Animals; Chronic Disease; Convulsants; Disease Models, Animal; Dystrophin; Epilepsy; | 2004 |
Genetic and phenotypic analysis of seizure susceptibility in PL/J mice.
Topics: Animals; Convulsants; Crosses, Genetic; Disease Models, Animal; Electroencephalography; Electroshock | 2004 |
The effects of the immature rat model of febrile seizures on the occurrence of later generalized tonic-clonic and absence epilepsy.
Topics: Action Potentials; Animals; Animals, Newborn; Brain; Causality; Convulsants; Disease Models, Animal; | 2005 |
Altered seizure susceptibility in mice lacking the Ca(v)2.3 E-type Ca2+ channel.
Topics: 4-Aminopyridine; Animals; Blotting, Western; Calcium Channels; Calcium Channels, T-Type; Disease Mod | 2006 |
A large-scale mutagenesis screen to identify seizure-resistant zebrafish.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Genetic Predisposition to Disease; Genetic Testin | 2007 |
Characterization of febrile seizures and febrile seizure susceptibility in mouse inbred strains.
Topics: Animals; Behavior, Animal; Convulsants; Electrophysiology; Fever; Genetic Predisposition to Disease; | 2008 |
Genotyping microsatellite polymorphisms by agarose gel electrophoresis with ethidium bromide staining: application to quantitative trait loci analysis of seizure susceptibility in mice.
Topics: Animals; Chromosome Mapping; Convulsants; Crosses, Genetic; DNA; Drug Resistance; Electrophoresis, A | 1998 |
Mapping loci for pentylenetetrazol-induced seizure susceptibility in mice.
Topics: Animals; Chromosome Mapping; Convulsants; Female; Genetic Predisposition to Disease; Genome; Genotyp | 1999 |
Susceptibility to focal and generalized seizures in Wistar rats with genetic absence-like epilepsy.
Topics: Animals; Convulsants; Electroencephalography; Epilepsies, Partial; Epilepsy, Absence; Epilepsy, Gene | 1999 |
Seizures and neuronal damage in mice lacking vesicular zinc.
Topics: Animals; Bicuculline; Carrier Proteins; Cation Transport Proteins; Convulsants; Dose-Response Relati | 2000 |
Genetic comparison of seizure control by norepinephrine and neuropeptide Y.
Topics: Animals; Dopamine beta-Hydroxylase; Exercise Test; Flurothyl; Genetic Predisposition to Disease; Han | 2001 |
Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7.
Topics: Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; Convulsants; Drug Resistance; Electroencepha | 2001 |
Reduced anxiety-- and depression-like behaviors in Emx1 homozygous mutant mice.
Topics: Acoustic Stimulation; Animals; Anxiety; Convulsants; Depression; Exploratory Behavior; Female; Genet | 2002 |