pentylenetetrazole has been researched along with Epilepsy in 857 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to examine the relationship between epilepsy and COX/5-LOX inflammation pathways in the penicillin and pentylenetetrazole (PTZ)-induced epilepsy models." | 8.31 | An involvement of COX and 5-LOX pathways in the penicillin- and pentylenetetrazole (PTZ)-induced epilepsy models. ( Taşdemir, A; Taskiran, M, 2023) |
| "Resistance to valproic acid (VPA) is a major challenge for epilepsy treatment." | 8.31 | Overexpression of Homer1b/c induces valproic acid resistance in epilepsy. ( Li, Y; Li, Z; Lu, J; Wang, G; Wang, Y, 2023) |
| "To investigate the effects of different doses of esculetin on epileptiform activity, behavioral seizures, memory impairment, and cortical and hippocampal NF-κB, as a mediator of pro-inflammatory gene induction, and pro-inflammatory cytokines in penicillin- and pentylenetetrazole(PTZ)-induced seizure models in rats." | 8.31 | Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats. ( Ankarali, H; Baranoglu Kilinc, Y; Danis, A; Hanci, F; Kilinc, E; Torun, IE, 2023) |
| " Activation of GPR39 by TC-G 1008 facilitated the development of epileptogenesis in the pentylenetetrazole (PTZ)-induced kindling model of epilepsy." | 8.31 | Dietary Zinc Differentially Regulates the Effects of the GPR39 Receptor Agonist, TC-G 1008, in the Maximal Electroshock Seizure Test and Pentylenetetrazole-Kindling Model of Epilepsy. ( Barałkiewicz, D; Doboszewska, U; Mlyniec, K; Nieoczym, D; Pieróg, M; Sajnóg, A; Sawicki, J; Socała, K; Sowa, I; Szewczyk, B; Wlaź, P, 2023) |
| "Tiagabine (Tia), a new-generation antiseizure drug that mimics the GABAergic signaling by inhibiting GABA transporter type-1, is the least studied molecule in chronic epilepsy models with comorbid neurobehavioral and neuroinflammatory parameters." | 8.31 | Tiagabine suppresses pentylenetetrazole-induced seizures in mice and improves behavioral and cognitive parameters by modulating BDNF/TrkB expression and neuroinflammatory markers. ( Ahmad, T; Alasmari, AF; Alasmari, F; Alqahtani, F; Alqarni, SA; Anjum, SMM; Ashraf, W; Imran, I; Javaid, S; Rasool, MF, 2023) |
| " Here, we evaluated its neuroprotective effects at different doses (100 and 200 mg/kg) against pentylenetetrazole (PTZ)-induced seizures." | 8.31 | Neuroprotective effects of Royal Jelly (RJ) against pentylenetetrazole (PTZ)-induced seizures in rats by targeting inflammation and oxidative stress. ( Dolatshahi, M; Hashemi, P; Karimpour, S; Nazarinia, D, 2023) |
| "Cannabidiol (CBD) is the main active ingredient in the cannabis plant used for treating epilepsy and related diseases." | 8.31 | The Potential Mechanism of Cannabidiol (CBD) Treatment of Epilepsy in Pentetrazol (PTZ) Kindling Mice Uncovered by Multi-Omics Analysis. ( He, M; Jiang, X; Lu, H; Wang, Q; Wei, M; Zhao, Y, 2023) |
| "To investigate the efficacy and mechanisms of Dingxian pill combined with valproic acid (VPA) on pentylenetetrazol-induced chronical epilepsy in rats." | 8.31 | Efficacy and mechanisms of Dingxian pill combined with valproic acid on pentylenetetrazol-induced chronic epilepsy in rats. ( Dongxiao, QU; Guoyi, LI; Jie, T; Jiwei, C; Liji, C; Limin, Z; Qian, X; Yiqin, GE; Yonghua, X; Yudan, Z, 2023) |
| " In the present work, BCRP's role as a mechanism that might contribute to drug-resistant epilepsy (DRE) in a mouse model of acute seizures was studied with further assessment of the effect of its inhibition by ko143 and metformin (MET) on lamotrigine (LTG) bioavailability and efficacy." | 8.31 | Implications of BCRP modulation on PTZ-induced seizures in mice: Role of ko143 and metformin as adjuvants to lamotrigine. ( El-Sayed, NS; Fathelbab, MH; Harby, SA; Khalil, NA; Saleh, SR; Thabet, EH, 2023) |
| " Inositols have proved effective in many disorders; hence, in the current study, we tested potential antiepileptic properties of scyllo-inositol (SCI)-one of the most common commercially available inositols-in zebrafish larvae with pentylenetetrazol-induced seizures." | 8.31 | Antiepileptic Properties of Scyllo-Inositol on Pentylenetetrazol-Induced Seizures. ( Antonowski, T; Juranek, J; Podlasz, P; Wiśniewski, K; Wojtkiewicz, J, 2023) |
| " Hence, the methanol extract was further explored for its anticonvulsant potential in pentylenetetrazole (PTZ) induced acute seizures in mice." | 8.31 | Anticonvulsant potential of Grewia tiliaefolia in pentylenetetrazole induced epilepsy: insights from in vivo and in silico studies. ( Arora, S; Kaur, S; Kumar, N; Rajput, A; Sharma, P; Singh Bedi, PM; Singh, B; Singh, H; Singh, S; Singh, T, 2023) |
| "A common way to investigate epilepsy and the effect of antiepileptic pharmaceuticals is to analyze the movement patterns of zebrafish larvae treated with different convulsants like pentylenetetrazol (PTZ), pilocarpine, etc." | 8.31 | A comparative study to optimize experimental conditions of pentylenetetrazol and pilocarpine-induced epilepsy in zebrafish larvae. ( Aly, N; Budan, F; Dittrich, B; Gorbe, A; Jin, M; Sik, A; Szentpeteri, JL; Szep, D, 2023) |
| " Here, we conducted present study to evaluate its neuroprotective effects against pentylenetetrazole (PTZ)-induced seizures in rats." | 8.31 | (-)-α-bisabolol exerts neuroprotective effects against pentylenetetrazole-induced seizures in rats by targeting inflammation and oxidative stress. ( Hashemi, P; Moslehi, A; Nazarinia, D, 2023) |
| "Serotonin and fluoxetine, but not sumatriptan, alleviated PTZ-induced seizures by prolonging onset times of myoclonic-jerk and generalized tonic-clonic seizures." | 8.12 | Endogenous and exogenous serotonin, but not sumatriptan, ameliorate seizures and neuroinflammation in the pentylenetetrazole-induced seizure model in rats. ( Kilinc, E; Kılınc, YB; Torun, IE, 2022) |
| "Pentylenetetrazole (PTZ)-induced kindling is an animal model for studying human temporal lobe epilepsy (TLE), which is characterized by alterations of hippocampal neurons and memory." | 8.12 | Protective Effects of Intranasally Administrated Oxytocin-Loaded Nanoparticles on Pentylenetetrazole-Kindling Epilepsy in Terms of Seizure Severity, Memory, Neurogenesis, and Neuronal Damage. ( Emik, S; Sahin, H; Senturk, GE; Yucel, O, 2022) |
| " Here we examine the effects of valproic acid (VA) plus 4-phenylbutyric acid (4-PBA) on abnormal electrical brain activity, ER stress and apoptosis in acute seizures induced by pentylenetetrazole (PTZ)." | 8.12 | 4-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole. ( Amanvermez, R; Arslan, G; Gün, S; Rzayev, E; Tiryaki, ES, 2022) |
| " This study investigated the effects and mechanisms of compound 48/80-stimulated mast cell activation on pentylenetetrazole-induced epileptic seizures in rats." | 8.12 | Mast cell activation ameliorates pentylenetetrazole-induced seizures in rats: The potential role for serotonin. ( Cetinkaya, A; Kilinc, E; Tore, F; Torun, IE, 2022) |
| "In spite of use of cannabidiol (CBD), a non-psychoactive cannabinoid, in pediatric patients with epilepsy, preclinical studies on its effects in immature animals are very limited." | 8.02 | Anticonvulsive Effects and Pharmacokinetic Profile of Cannabidiol (CBD) in the Pentylenetetrazol (PTZ) or N-Methyl-D-Aspartate (NMDA) Models of Seizures in Infantile Rats. ( Hložek, T; Kubová, H; Mareš, P; Páleníček, T; Uttl, L, 2021) |
| " In the pharmacodynamic interaction study, seizures were induced using pentylenetetrazole (PTZ) (60 mg/kg, i." | 8.02 | Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats. ( Agarwal, A; Arora, R; Ganeshan N, S; Gupta, YK; Kaleekal, T; Kumar, R; Sarangi, SC, 2021) |
| "The primary cause of seizure-induced death for all mice was apnea, as (1) apnea began during a seizure and continued for tens of minutes until terminal asystole, and (2) death was prevented by mechanical ventilation." | 8.02 | Postictal Death Is Associated with Tonic Phase Apnea in a Mouse Model of Sudden Unexpected Death in Epilepsy. ( Blizzard, EA; Goodkin, HP; Meisler, MH; Panchal, PS; Patel, MK; Richerson, GB; Saraf, P; Teran, FA; Wagley, PK; Wagnon, JL; Wengert, ER; Wenker, IC, 2021) |
| " The study looked at how the thiamine supplement impacted pentylenetetrazole (PTZ)-induced seizures in rats and pentylenetetrazole-induced neurotoxicity in the SH-SY5Y cell line." | 8.02 | The modulator action of thiamine against pentylenetetrazole-induced seizures, apoptosis, nitric oxide, and oxidative stress in rats and SH-SY5Y neuronal cell line. ( Ergul, M; Taskiran, AS, 2021) |
| "A model of acute epilepsy in mice was established using the Pentylenetetrazol (PTZ) ignition method to evaluate the effects of Rhein on the duration and latency of convulsions, and the number and severity of seizures." | 8.02 | Rhein attenuates PTZ‑induced epilepsy and exerts neuroprotective activity via inhibition of the TLR4-NFκB signaling pathway. ( Cao, J; Li, X; Yang, J; Yu, L; Yu, W, 2021) |
| " We investigated effects of long-term probiotics supplementation on epileptic seizures, and inflammatory and oxidant/antioxidant biomarkers in a pentylenetetrazole(PTZ)-induced seizure model in rats." | 8.02 | Protective effects of long-term probiotic mixture supplementation against pentylenetetrazole-induced seizures, inflammation and oxidative stress in rats. ( Ankarali, H; Ankarali, S; Ayhan, D; Cetinkaya, A; Kilinc, E; Torun, IE, 2021) |
| "Epilepsy was induced in rats by injecting Pentylenetetrazole at 35 mg/kg every other day." | 7.96 | Glutamatergic pathway in depressive-like behavior associated with pentylenetetrazole rat model of epilepsy with history of prolonged febrile seizures. ( Alese, OO; Mabandla, MV; Mkhize, NV; Ngoupaye, GT; Rakgantsho, C; Zulu, S, 2020) |
| " This study aimed to investigate the effect of sCT on epileptic seizures, epileptogenesis, and postseizure hippocampal neuronal damage in pentylenetetrazole (PTZ)-induced epilepsy model in rats." | 7.96 | The effects of salmon calcitonin on epileptic seizures, epileptogenesis, and postseizure hippocampal neuronal damage in pentylenetetrazole-induced epilepsy model in rats. ( Ergul, M; Gumus, E; Ozdemir, E; Taskıran, AS, 2020) |
| "The present study was designed to examine the possible neuroprotective and antiepileptic effects of metformin (Metf) in a rat model of pentylenetetrazole (PTZ)-induced epilepsy and its possible underlying mechanisms." | 7.91 | Effects of metformin on apoptosis and α-synuclein in a rat model of pentylenetetrazole-induced epilepsy. ( Abbas, KM; Abulseoud, OA; Ali, AN; El-Mesery, M; El-Shafey, M; Eldosoky, M; Hussein, AM, 2019) |
| " The present study was designed to evaluate the effect of arbutin supplementation on seizures behavior, memory performance, glial activation, release of inflammatory factors and neuroprotection in pentylenetetrazole-induced kindling model." | 7.91 | Arbutin attenuates cognitive impairment and inflammatory response in pentylenetetrazol-induced kindling model of epilepsy. ( Ahmadian, SR; Ghasemi-Kasman, M; Pouramir, M; Sadeghi, F, 2019) |
| "The effects of edaravone against pentylenetetrazole (PTZ)-induced epilepsy in male albino rats were investigated." | 7.91 | Edaravone acts as a potential therapeutic drug against pentylenetetrazole-induced epilepsy in male albino rats by downregulating cyclooxygenase-II. ( Liu, LM; Lu, Y; Wang, N; Wang, WP, 2019) |
| " The aim of this study was to evaluate the effects of corilagin, an ellagitannin extracted from medicinal plants, on the frequency of seizures and cognitive function in a rat model of chronic epilepsy." | 7.88 | Corilagin Reduces the Frequency of Seizures and Improves Cognitive Function in a Rat Model of Chronic Epilepsy. ( Chang, LY; Wei, LL; Yu, H; Yu, X; Zhou, T, 2018) |
| " All rats except those from the sham group were treated with PTZ to establish temporal lobe epilepsy (TLE) models, whereas the P38 MAPK inhibitor SB 203580 was given to the inhibitor group." | 7.85 | P38 MAPK pathway mediates cognitive damage in pentylenetetrazole-induced epilepsy via apoptosis cascade. ( Huang, Q; Huang, Y; Liao, Y; Liu, X; Ma, M; Wei, X; Wu, Y, 2017) |
| " Ferulic acid is a phenolic phytochemical with antioxidant and neuroprotective properties that prompted us to evaluate its therapeutic potential in epilepsy which is usually associated with oxidative stress and cognitive decline." | 7.85 | Ferulic acid exhibits antiepileptogenic effect and prevents oxidative stress and cognitive impairment in the kindling model of epilepsy. ( Arbabi, E; Atyabi, F; Dinarvand, R; Hassanzadeh, P, 2017) |
| " The present study was designed to investigate synergistic anticonvulsant effects of pregabalin with amlodipine on acute seizure model of epilepsy in mice." | 7.85 | Synergistic anticonvulsant effects of pregabalin and amlodipine on acute seizure model of epilepsy in mice. ( Khan, RA; Qureshi, IH; Riaz, A; Siddiqui, AA, 2017) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 7.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| "There is considerable interest in using bumetanide, a chloride importer Na-K-Cl cotransporter antagonist, for treatment of neurological diseases, such as epilepsy or ischemic and traumatic brain injury, that may involve deranged cellular chloride homeostasis." | 7.80 | A novel prodrug-based strategy to increase effects of bumetanide in epilepsy. ( Brandt, C; Brunhofer, G; Erker, T; Feit, PW; Gabriel, M; Kaila, K; Lindfors, J; Löscher, W; Töllner, K; Töpfer, M, 2014) |
| "The aims of this study were to characterize a lamotrigine-resistant kindled model of epilepsy in mice, to study the anticonvulsant effect of carbamazepine (CBZ) and valproic acid (VPA), and to probe into the mechanism for resistance." | 7.80 | Characterization of a lamotrigine-resistant kindled model of epilepsy in mice: evaluation of drug resistance mechanisms. ( Mehndiratta, M; Pillai, KK; Singh, E, 2014) |
| " Pentylenetetrazole (PTZ)-kindled and spontaneous model of epilepsy (EL) mice were used as models of chemically induced and spontaneous epilepsy, respectively." | 7.80 | Pharmacoproteomics-based reconstruction of in vivo P-glycoprotein function at blood-brain barrier and brain distribution of substrate verapamil in pentylenetetrazole-kindled epilepsy, spontaneous epilepsy, and phenytoin treatment models. ( Ohtsuki, S; Terasaki, T; Uchida, Y, 2014) |
| "The present study was aimed to investigate the potential beneficial effect of curcumin, a polyphenol with pleiotropic properties, on mitochondrial dysfunctions, oxidative stress and cognitive deficits in a kindled model of epilepsy." | 7.80 | Curcumin supplementation improves mitochondrial and behavioral deficits in experimental model of chronic epilepsy. ( Bal, A; Kaur, H; Sandhir, R, 2014) |
| "These data indicate that MSCs were superior to gabapentin in ameliorating PTZ-induced epileptogenesis and verified the potential use of MSCs in seizure control, motor and cognitive impairments, oxidative stress, and the impairing GABA level in experimentally induced epilepsy." | 7.80 | Effects of intravenous human umbilical cord blood mesenchymal stem cell therapy versus gabapentin in pentylenetetrazole-induced chronic epilepsy in rats. ( Essawy, SS; Ewais, MM; Mohammed, AS; Tawfik, MK, 2014) |
| "The anticonvulsant effect of dicholine succinate (DCS), a neuronal insulin sensitizer, has been studied on two models of primary generalized epilepsy induced by corazole and maximal electroshock (ME) in mice." | 7.79 | [Anticonvulsant effect of dicholine succinate on primary generalized epilepsy model in mice]. ( Pomytkin, IA; Rychikhin, VM; Sariev, AK, 2013) |
| " (MQ) in maximal electroshock (MES) and pentylenetetrazole (PTZ) induced rat models of epilepsy." | 7.79 | Evaluation of anti-epileptic property of Marsilea quadrifolia Linn. in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy. ( Avinash, H; Chandrashekar, BR; Mukunda, N; Naduvil Narayanan, S; Nayak, BS; Raghavendra Rao, K; Sadhana, N; Satish Kumar, MC; Snehunsu, A; Vijay Kapgal, K, 2013) |
| " Thus, this study was carried out to evaluate the acute effect of liposome-entrapped curcumin on increasing current electroshock seizures (ICES) test, pentylenetetrazole (PTZ)-induced seizures, and status epilepticus in mice." | 7.79 | Liposomal formulation of curcumin attenuates seizures in different experimental models of epilepsy in mice. ( Agarwal, NB; Agarwal, NK; Jain, S; Mediratta, PK; Nagpal, D; Sharma, KK, 2013) |
| "We aimed to reveal the anti-convulsant effects of oxytocin (OT) in pentylenetetrazol (PTZ)-induced seizures in rats." | 7.79 | Oxytocin inhibits pentylentetrazol-induced seizures in the rat. ( Bora, S; Erbas, O; Evren, V; Korkmaz, HA; Peker, G; Yılmaz, M, 2013) |
| "Clinical reports have shown that some antihistamines, such as ketotifen, occasionally produced seizures, especially in pre-school age children or young patients with epilepsy." | 7.78 | The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats. ( Kanda, T; Takizawa, F; Tamura, T; Yamada, K, 2012) |
| "Wuling mycelia can delay the kindling and ameliorate the ability of learning in rats with pentylenetetrazole-induced epilepsy and the enhancement of neuronal histamine activity may be one of possible mechanisms." | 7.78 | [Effects of Wuling mycelia on pentylenetetrazole-induced epilepsy in rats]. ( Chen, GF; Hu, XY; Ren, GL; Zhang, LS, 2012) |
| "The effects of the halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine (3,5-DBr-D: -Tyr) were studied in rat models of stroke and epileptic seizures caused by middle cerebral artery occlusion (MCAo) through respective intracerebral injection of endothelin-1 (ET-1) and intraperitoneal (i." | 7.77 | Halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine produces beneficial effects in experimental stroke and seizures. ( Cao, W; Glushakov, A; Martynyuk, AE; Mecca, AP; Seubert, CN; Shah, HP; Shi, P; Sumners, C, 2011) |
| "The aim of present study was to examine the effects of the ethyl acetate fraction (EAF) from Platonia insignis on lipid peroxidation level, nitrite formation, and superoxide dismutase and catalase activities in rat striatum prior to pilocarpine-induced seizures as well as to explore its anticonvulsant activity in adult rats prior to pentylenetetrazole (PTZ)- and picrotoxin (PIC)-induced seizures." | 7.77 | Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models. ( Citó, AM; de Almeida, AA; de Freitas, RM; Júnior, JS; Saffi, J; Tomé, Ada R, 2011) |
| "To characterize the type of interactions between vigabatrin (VGB) and tiagabine (TGB) -- two newer antiepileptic drugs influencing GABA-ergic neurotransmitter system, the isobolographic analysis was used in two experimental models of epilepsy: the maximal electroshock seizure threshold (MEST) test and pentylenetetrazole (PTZ)-induced seizures in mice." | 7.74 | Isobolographic characterization of interactions between vigabatrin and tiagabine in two experimental models of epilepsy. ( Czuczwar, SJ; Luszczki, JJ, 2007) |
| "This paper comprises a series of experiments in rodent models of partial and generalized epilepsy which were designed to describe the anti-convulsant profile of the functionalized amino acid lacosamide." | 7.74 | Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy. ( Choi, D; Harris, RH; Kohn, H; Kupferberg, HJ; Stables, JP; Stöhr, T; Walton, N; White, HS, 2007) |
| "To investigate the mechanisms of memory impairment induced by pentylenetetrazole (PTZ)-kindled epilepsy in rats and the effects of endogenous histamine." | 7.73 | [Effects of endogenous histamine on memory impairment induced by pentylenetetrazole-kindled epilepsy in rats]. ( Li, Q; Ma, YY; Zhang, LS, 2006) |
| "The study investigated the activity of harmane on maximal electroshock seizures (MES) and seizures induced by pentilentetrazole (PTZ) in mice." | 7.72 | Effect of harmane on the convulsive threshold in epilepsy models in mice. ( Aricioglu, F; Berkman, K; Korcegez, E; Yillar, O, 2003) |
| "To investigate the mechanisms of histamine on chronic epilepsy induced by pentylenetetrazole (PTZ)." | 7.72 | [Mechanisms of the effect of brain histamine on chronic epilepsy induced by pentylenetetrazole]. ( Chen, Z; Hu, WW; Jin, CL; Shen, HQ; Zhang, LS; Zhao, MH, 2004) |
| "A 10 mmol/kg injection of acetone suppressed seizures in 60% of rats (P<0." | 7.71 | Ketogenic diet: does acetone stop seizures? ( Burnham, WM; Likhodii, SS, 2002) |
| "This work describes a novel epilepsy model, combining pentylenetetrazole (PTZ) kindling with the senescence-accelerated mouse P8 (SAMP8) a model for aging." | 7.71 | The pentylenetetrazole-kindling model of epilepsy in SAMP8 mice: behavior and metabolism. ( Bidar, A; Kondziella, D; Sletvold, O; Sonnewald, U; Urfjell, B, 2002) |
| "The anticonvulsive activity of nociceptin, endogenous OP4 receptors agonist was investigated in pentylenetetrazole (PTZ), N-methyl D-aspartic acid (NMDA), bicucculine (BCC) and electrically evoked seizure models of experimental epilepsy." | 7.71 | Nociceptin, OP4 receptor ligand in different models of experimental epilepsy. ( Gustaw, K; Rubaj, A; Sieklucka-Dziuba, M; Zgodzinski, W, 2002) |
| "The protective and adverse effect potentials of levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide) in rodent models of seizures and epilepsy were compared with the profile of several currently prescribed and newly developed antiepileptic drugs." | 7.70 | Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. ( Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E, 1998) |
| "The purpose of this study was to test the hypothesis that a ketogenic diet would increase the resistance of rats to pentylenetetrazole (PTZ)-induced seizures and to understand the relation of ketonemia to seizure resistance." | 7.70 | A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat. ( Bough, KJ; Eagles, DA, 1999) |
| ") administration, were studied against audiogenic seizures in genetically epilepsy-prone rats (GEPRs) or pentylenetetrazole induced kindling in rats." | 7.70 | Effects of some AMPA receptor antagonists on the development of tolerance in epilepsy-prone rats and in pentylenetetrazole kindled rats. ( De Sarro, A; De Sarro, G; Di Paola, ED; Gallelli, L; Gareri, P; Scotto, G, 1999) |
| "Perimenstrual catamenial epilepsy, the exacerbation of seizures in association with menstruation, may in part be due to withdrawal of the progesterone metabolite allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), an endogenous anticonvulsant neurosteroid that is a positive allosteric modulator of gamma-aminobutyric acid(A) receptors." | 7.70 | Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2000) |
| " A nearly fivefold elevation in NO content was found at the peak time of pentylenetetrazole (PTZ)-induced seizures." | 7.70 | Nitric oxide content measured by ESR-spectroscopy in the rat brain is increased during pentylenetetrazole-induced seizures. ( Bashkatova, V; Mikoyan, V; Narkevich, V; Rayevsky, K; Vanin, A; Vitskova, G, 2000) |
| "The anticonvulsant potency of 2-propyl-2-pentenoic acid (2-en-VPA; trans isomer), a major metabolite of the antiepileptic valproic acid (VPA), was evaluated in different animal models of epilepsy and compared with the respective data for VPA." | 7.67 | Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy. ( Löscher, W; Marescaux, C; Nau, H; Vergnes, M, 1984) |
| "In patients with suspected epilepsy, an EEG "activation" with bemegride can be performed as last link of the diagnostic chain." | 7.67 | [EEG activation with bemegride in epilepsy diagnosis. 1: Literature review]. ( Bülau, P; Fröscher, W, 1984) |
| "The seizure sensitive Mongolian gerbil, a genetic model of epilepsy, has been used to investigate the effects of prior spontaneous seizures on the threshold for pentylenetetrazole (PTZ) and maximum electroshock (MES) induced convulsions." | 7.67 | The effect of spontaneous seizures on pentylenetetrazole and maximum electroshock induced seizures in the Mongolian gerbil. ( Lee, RJ; Lomax, P, 1984) |
| "The involvement of intranigral gamma-aminobutyric acid (GABA) receptors in the control of generalized non-convulsive epilepsy was investigated in the rat in 3 models of petit mal epilepsy induced by systemic administration of gamma-butyrolactone, pentylenetetrazol and 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridin 3-ol (THIP)." | 7.67 | Suppressive effects of intranigral injection of muscimol in three models of generalized non-convulsive epilepsy induced by chemical agents. ( Depaulis, A; Marescaux, C; Snead, OC; Vergnes, M, 1989) |
| "Epilepsy is a complex neurological disease characterized by spontaneous recurrent seizures that affect around 1% of the global population." | 5.91 | Comprehensive characterization of amino acids and water-soluble vitamins in a pentylenetetrazole-induced seizures rat model. ( Jiang, X; Liu, J; Wang, Y, 2023) |
| "Epilepsy is one of the most serious worldwide neurological disorders that lead to the cognitive-psychosocial insults in recurrent seizures." | 5.91 | Ceftriaxone and selenium mitigate seizures and neuronal injury in pentylenetetrazole-kindled rats: Oxidative stress and inflammatory pathway. ( Abdelaziz, EZ; Ali, DA; Kolieb, E; Mohamed, AM, 2023) |
| "Epilepsy is caused by an excessive recurrent excitatory neuronal firing, characterized by motor, psychomotor, and sensory impairments." | 5.91 | Impact of noscapine on halting the progression of pentylenetetrazole induced kindling epilepsy in mice. ( Dhureja, M; Gupta, R; Kumar, P; Soni, D; Upadhayay, S, 2023) |
| "Epilepsy is a prevalent neurological disease, affecting approximately 1-2% of the global population." | 5.91 | Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish. ( Benvenutti, R; Chitolina, R; Herrmann, AP; Linazzi, A; Marcon, M; Piato, A; Reis, CG; Stahlhofer-Buss, T, 2023) |
| "Epilepsy is one of the most common chronic neurological diseases." | 5.72 | Vitamin E Exerts Neuroprotective Effects in Pentylenetetrazole Kindling Epilepsy via Suppression of Ferroptosis. ( Guo, C; Guo, K; Hu, Z; Li, J; Peng, J; Wu, S; Zhang, X; Zhang, Z, 2022) |
| "Epilepsy is one of the most common serious brain disorders, affecting about 1% of the population all over the world." | 5.72 | Anti-kindling effect of Ginkgo biloba leaf extract and L-carnitine in the pentylenetetrazol model of epilepsy. ( Abd El-Gawad, HS; Abd Elkader, HAE; Alhasani, RH; El-Sayed, SA; Essawy, AE; Tousson, E, 2022) |
| " However, the low bioavailability of resveratrol and the difficulty of reaching the targeted location in the brain reduce its efficacy considerably." | 5.72 | Resveratrol-Loaded Glutathione-Coated Collagen Nanoparticles Attenuate Acute Seizures by Inhibiting HMGB1 and TLR-4 in the Hippocampus of Mice. ( Aggarwal, NB; Akhter, J; Arora, I; Asad, M; Hoda, U; Rastogi, S; Samim, M; Siddiqui, MA, 2022) |
| "Evidence suggests that improving brain inflammation can inhibit the epileptogenesis process and help the emergence of new drugs for the treatment of epilepsy." | 5.72 | Thiamine alleviates cognitive impairment and epileptogenesis by relieving brain inflammation in PTZ-induced kindling rat model. ( Akkaya, R; Filiz, AK; Karabulut, S, 2022) |
| "Epileptic seizures are associated with the overproduction of free radicals in the brain leading to neuronal cell death." | 5.72 | The Effects of Vitamin D3 and Melatonin Combination on Pentylenetetrazole- induced Seizures in Mice. ( Dehdashtian, E; Hosseinzadeh, A; Jafari-Sabet, M; Mehrzadi, S, 2022) |
| "Epilepsy is characterized by the occurrence of seizures, and the high prevalence of epilepsy-associated comorbidities affects the quality of patients' life." | 5.72 | Pentylenetetrazole-induced seizures cause impairment of memory acquisition and consolidation in zebrafish (Danio rerio). ( Bertoncello, KT; Bonan, CD; Zanandrea, R, 2022) |
| "Epilepsy is often considered to be a progressive neurological disease, and the nature of this progression remains unclear." | 5.72 | Insights into the development of pentylenetetrazole-induced epileptic seizures from dynamic metabolomic changes. ( Cheng, P; Jia, P; Liao, S; Meng, K; Xiao, C; Xu, R; Zhao, X; Zheng, X, 2022) |
| "Ferulic acid treatment, on the other hand, significantly decreased seizure susceptibility and depression like behavior, possibly because of increased progesterone, restored estradiol, corticosterone, monoamines, and GAD enzyme activity." | 5.72 | Ferulic acid inhibits catamenial epilepsy through modulation of female hormones. ( Dhillon, HK; Goel, RK; Singh, T, 2022) |
| "In various organisms, stress is a seizure-related comorbidity." | 5.62 | Stress increases susceptibility to pentylenetetrazole-induced seizures in adult zebrafish. ( Canzian, J; Franscescon, F; Müller, TE; Rosa, LV; Rosemberg, DB; Souza, TP; Stefanello, FV, 2021) |
| "The present study aims to evaluate the efficacy of selenium (Se) alone or combined with carbamazepine (CBZ) against the adverse effects induced by the chemoconvulsant pentylenetetrazole (PTZ) in the cortex of adult male rats." | 5.56 | Electrophysiological and Neurochemical Assessment of Selenium Alone or Combined with Carbamazepine in an Animal Model of Epilepsy. ( Aboul Ezz, HS; Ali, MA; Mohammed, HS; Zedan, A, 2020) |
| "In India, it is used for the treatment of epilepsy as traditional medicine." | 5.56 | An interaction study of Ocimum sanctum L. and levetiracetam in pentylenetetrazole kindling model of epilepsy. ( Dinda, AK; Kaleekal, T; Katyal, J; Pattnaik, SS; Sarangi, SC, 2020) |
| "Epilepsy is a debilitating neurological illness that affects all aspect of an individual life." | 5.56 | Prolonged febrile seizure history exacerbates seizure severity in a pentylenetetrazole rat model of epilepsy. ( Alese, OO; Mabandla, MV; Mkhize, NV; Rakgantsho, C; Zulu, S, 2020) |
| "Piperine is a chief alkaloid compound of natural black pepper exhibits excellent anti-convulsant efficiency in the anti-epileptic treatment." | 5.56 | Rational design of ultra-small photoluminescent copper nano-dots loaded PLGA micro-vessels for targeted co-delivery of natural piperine molecules for the treatment for epilepsy. ( Ding, SW; Nie, XD; Yang, L; Zhang, DT; Zhang, WG; Zhu, D, 2020) |
| "Ibuprofen (IBP) is a well-known anti-inflammatory agent that reduces the neuroinflammatory response and neuronal damage." | 5.56 | Ibuprofen Exerts Antiepileptic and Neuroprotective Effects in the Rat Model of Pentylenetetrazol-Induced Epilepsy via the COX-2/NLRP3/IL-18 Pathway. ( Guo, C; Guo, K; Hu, Z; Li, J; Liu, R; Peng, J; Wu, S; Zhang, X, 2020) |
| "Epilepsy is a chronic neurological disease." | 5.51 | Effect of Ibuprofen on Autophagy of Astrocytes During Pentylenetetrazol-Induced Epilepsy and its Significance: An Experimental Study. ( Guo, C; Guo, K; Hu, Z; Li, J; Liu, R; Peng, J; Wu, S; Zhang, W, 2019) |
| "The animals were assessed for seizure score, neuronal damage and inflammatory cytokines levels (IL-1β, IL-6 and TNF-α) in hippocampus." | 5.51 | Effect of dimethyl fumarate on neuroinflammation and apoptosis in pentylenetetrazol kindling model in rats. ( Banerjee, D; Bhatia, A; Chakrabarti, A; Kumari, P; Saha, L; Singh, J; Singh, N, 2019) |
| "Epilepsy is a common clinical syndrome characterized by sudden and recurrent attacks and temporary central nervous system dysfunction caused by excessive discharge of neurons in the brain." | 5.51 | Exploratory Cortex Metabolic Profiling Revealed the Sedative Effect of Amber in Pentylenetetrazole-Induced Epilepsy-Like Mice. ( Chen, C; Duan, J; Guo, J; Guo, S; Qian, D; Shang, E; Tang, Z; Yan, H; Zhao, M; Zhu, Y; Zhu, Z, 2019) |
| "Epilepsy is one of the furthermost common neurodegenerative diseases affecting above 50 million individuals worldwide." | 5.48 | Neuroprotective mechanisms of sildenafil and selenium in PTZ-kindling model: Implications in epilepsy. ( El-Azab, MF; Moustafa, YM; Tawfik, KM, 2018) |
| "Epilepsy is a chronic neurological disorder which affects 65 million worldwide population and characterized by recurrent seizure in epileptic patients." | 5.48 | The anti-epileptogenic and cognition enhancing effect of novel 1-[4-(4-benzo [1, 3] dioxol-5-ylmethyl-piperazin-1-yl)-phenyl]-3-phenyl-urea (BPPU) in pentylenetetrazole induced chronic rat model of epilepsy. ( Kumari, S; Mishra, CB; Siraj, F; Tiwari, AK; Tiwari, M; Yadav, R, 2018) |
| "BACKGROUND Epilepsy is a complex neurologic disorder with abnormal electrical impulses in the brain." | 5.48 | Modulation of P2X Purinoceptor 3 (P2X3) in Pentylenetetrazole-Induced Kindling Epilepsy in Rats. ( Han, Z; Wang, H; Xia, J; Zhang, Q, 2018) |
| "Seizures are sustained neuronal hyperexcitability in brain that result in loss of consciousness and injury." | 5.48 | Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish. ( Han, L; He, Q; Ji, X; Jin, M; Liu, K; Sheng, W, 2018) |
| "In six-hertz-seizure test the MeCO (25, 50, 100 and 200mg/kg) and AeCO (50, 100, 200, 400 and 800mg/kg) showed significant protection compared to control group, and MeCO was more potent than AeCO." | 5.46 | Ameliorative potential of Colebrookea oppositifolia methanolic root extract against experimental models of epilepsy: Possible role of GABA mediated mechanism. ( Prasad, NBL; Venkataranganna, MV; Viswanatha, GL, 2017) |
| "Epilepsy is fourth most common neurological disorders associated with depression and cognitive deficits." | 5.46 | Agmatine for combined treatment of epilepsy, depression and cognitive impairment in chronic epileptic animals. ( Bagga, N; Gawande, DY; Goel, RK; Kaur, A; Kaur, N; Singh, T, 2017) |
| "for 15 days." | 5.46 | Ferulic Acid Supplementation for Management of Depression in Epilepsy. ( Goel, RK; Kaur, T; Singh, T, 2017) |
| "Lamotrigine (LTG) is a broad-spectrum antiepileptic drug that is widely used in clinic." | 5.46 | Effect of lamotrigine on epilepsy-induced cognitive impairment and hippocampal neuronal apoptosis in pentylenetetrazole-kindled animal model. ( Dong, RF; Tian, S; Wang, WP; Zhang, B; Zhang, C; Zhang, JW, 2017) |
| "Epilepsy is a common brain disorder characterized by the occurrence of recurring, unprovoked seizures." | 5.46 | EGAR, A Food Protein-Derived Tetrapeptide, Reduces Seizure Activity in Pentylenetetrazole-Induced Epilepsy Models Through α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionate Receptors. ( Cai, M; Cai, S; Chen, L; Duan, S; Gu, H; Lin, R; Ling, C; Lu, J; Pan, X; Wang, Y; Zhu, H, 2017) |
| "Depression was evaluated in all experimental groups using the tail suspension and sucrose preference test on days 1, 5, 10 and 15, 2 h after pentylenetetrazole challenge." | 5.46 | Adjuvant quercetin therapy for combined treatment of epilepsy and comorbid depression. ( Goel, RK; Kaur, T; Singh, T, 2017) |
| "Pretreatment with spermine, considerably, reversed the PTZ induced alterations." | 5.46 | Protective effect of spermine against pentylenetetrazole kindling epilepsy induced comorbidities in mice. ( Kumar, M; Kumar, P, 2017) |
| "Understanding how the brain responds to seizures is important for development of new treatment strategies for epilepsy, a neurological condition characterized by recurrent and unprovoked seizures." | 5.46 | Cellular responses to recurrent pentylenetetrazole-induced seizures in the adult zebrafish brain. ( Beattie, CE; Berberoglu, MA; Duy, PQ; Hall, CW, 2017) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 5.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "Pre-treatment with liraglutide (75 and 150 μg/kg) significantly prevented the seizure severity, restored behavioural activity, oxidative defence enzymes, and altered level of neurochemicals in mice brain." | 5.43 | Neurochemical modulation involved in the beneficial effect of liraglutide, GLP-1 agonist on PTZ kindling epilepsy-induced comorbidities in mice. ( Koshal, P; Kumar, P, 2016) |
| "BACKGROUND Epilepsy is the most predominant neurological disorder characterized by recurrent seizures." | 5.43 | Garcinol Upregulates GABAA and GAD65 Expression, Modulates BDNF-TrkB Pathway to Reduce Seizures in Pentylenetetrazole (PTZ)-Induced Epilepsy. ( Hao, F; Jia, LH; Li, XW; Liu, XW; Zhang, YR, 2016) |
| "Modafinil, is a wake-promoting drug approved by Food and Drugs Administration (FDA) for narcolepsy and sleep-apnoe syndrome." | 5.42 | Effects of modafinil on pentylenetetrazol-induced convulsive epilepsy. ( Aydin, D; Ekici, F; Ozsoy, S, 2015) |
| "Topiramate (TOP) is a novel drug with broad antiepileptic effect, and its effect on brain cortex MMCA is not known." | 5.37 | Topiramate modulates hippocampus NMDA receptors via brain Ca(2+) homeostasis in pentylentetrazol-induced epilepsy of rats. ( Kutluhan, S; Naziroğlu, M; Vural, H; Yilmaz, M; Yilmaz, N; Yürekli, VA, 2011) |
| "Single seizure and epilepsy is one of the most commonly encountered neurologic disorders in elderly individuals, arising as a result of complex and often multiple acquired underlying pathologies." | 5.35 | Effects of progesterone on total brain tissue adenosine deaminase activity in experimental epilepsy. ( Alptekin, M; Erkutlu, I; Kurtul, N; Pençe, S; Tan, U, 2009) |
| "The intensities of seizures induced by pentylenetetrazol or pilocarpine, as well as the percentages of convulsing mice, were significantly reduced in A(2A) receptor knockout (A(2A)R KO) animals." | 5.35 | Adenosine A2A receptor deficient mice are partially resistant to limbic seizures. ( Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM, 2009) |
| "infusion of PTZ; (2) suppress the seizures (clonic and tonic) and lethality induced by i." | 5.33 | Anti-epileptogenic effect of beta-carotene and vitamin A in pentylenetetrazole-kindling model of epilepsy in mice. ( Narenjkar, J; Sayyah, M; Yousefi-Pour, M, 2005) |
| "In PTZ-induced epileptic seizures, the i." | 5.33 | Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. ( Hosseinzadeh, H; Mansouri, MT; Nassiri-Asl, M; Parvardeh, S, 2005) |
| "These results suggest that NPY reduces seizures of hippocampal origin through activation of Y(5) receptors." | 5.31 | Neuropeptide Y and epilepsy: varying effects according to seizure type and receptor activation. ( Benmaamar, R; Carnahan, J; Depaulis, A; Larmet, Y; Marescaux, C; Nadi, S; Reibel, S, 2001) |
| "Dexmedetomidine (DEX) is a highly selective alpha 2 agonist with marked sedative and analgesic properties thought to be mediated via reduction of central noradrenergic transmission." | 5.29 | Dexmedetomidine decreases seizure threshold in a rat model of experimental generalized epilepsy. ( McPherson, RW; Mirski, MA; Rossell, LA; Traystman, RJ, 1994) |
| "Pretreatment with felbamate at either dose prevented the progression of rank of seizures during chronic treatment with PTZ." | 5.29 | Anticonvulsant effect of felbamate in the pentylenetetrazole kindling model of epilepsy in the rat. ( Carboni, G; Corda, MG; Feldman, A; Frau, V; Giorgi, O; Orlandi, M; Valentini, V, 1996) |
| "After daily repeated PTZ convulsions, a significant increase of A1 receptors by 26% appeared also in cortex, while the changes of A1 receptors observed in the other brain areas after a single PTZ convulsion were maintained in almost the same range." | 5.28 | Alterations of A1 adenosine receptors in different mouse brain areas after pentylentetrazol-induced seizures, but not in the epileptic mutant mouse 'tottering'. ( Angelatou, F; Kostopoulos, G; Pagonopoulou, O, 1990) |
| "This study aimed to examine the relationship between epilepsy and COX/5-LOX inflammation pathways in the penicillin and pentylenetetrazole (PTZ)-induced epilepsy models." | 4.31 | An involvement of COX and 5-LOX pathways in the penicillin- and pentylenetetrazole (PTZ)-induced epilepsy models. ( Taşdemir, A; Taskiran, M, 2023) |
| "Resistance to valproic acid (VPA) is a major challenge for epilepsy treatment." | 4.31 | Overexpression of Homer1b/c induces valproic acid resistance in epilepsy. ( Li, Y; Li, Z; Lu, J; Wang, G; Wang, Y, 2023) |
| "05) and STR (42%) and had no effect on pilocarpine-induced seizures." | 4.31 | Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity. ( Adassi, MB; Foutsop, AF; Kom, TD; Ngo Bum, E; Ngoupaye, GT; Yassi, FB, 2023) |
| "To investigate the effects of different doses of esculetin on epileptiform activity, behavioral seizures, memory impairment, and cortical and hippocampal NF-κB, as a mediator of pro-inflammatory gene induction, and pro-inflammatory cytokines in penicillin- and pentylenetetrazole(PTZ)-induced seizure models in rats." | 4.31 | Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats. ( Ankarali, H; Baranoglu Kilinc, Y; Danis, A; Hanci, F; Kilinc, E; Torun, IE, 2023) |
| " Activation of GPR39 by TC-G 1008 facilitated the development of epileptogenesis in the pentylenetetrazole (PTZ)-induced kindling model of epilepsy." | 4.31 | Dietary Zinc Differentially Regulates the Effects of the GPR39 Receptor Agonist, TC-G 1008, in the Maximal Electroshock Seizure Test and Pentylenetetrazole-Kindling Model of Epilepsy. ( Barałkiewicz, D; Doboszewska, U; Mlyniec, K; Nieoczym, D; Pieróg, M; Sajnóg, A; Sawicki, J; Socała, K; Sowa, I; Szewczyk, B; Wlaź, P, 2023) |
| "Tiagabine (Tia), a new-generation antiseizure drug that mimics the GABAergic signaling by inhibiting GABA transporter type-1, is the least studied molecule in chronic epilepsy models with comorbid neurobehavioral and neuroinflammatory parameters." | 4.31 | Tiagabine suppresses pentylenetetrazole-induced seizures in mice and improves behavioral and cognitive parameters by modulating BDNF/TrkB expression and neuroinflammatory markers. ( Ahmad, T; Alasmari, AF; Alasmari, F; Alqahtani, F; Alqarni, SA; Anjum, SMM; Ashraf, W; Imran, I; Javaid, S; Rasool, MF, 2023) |
| " Here, we evaluated its neuroprotective effects at different doses (100 and 200 mg/kg) against pentylenetetrazole (PTZ)-induced seizures." | 4.31 | Neuroprotective effects of Royal Jelly (RJ) against pentylenetetrazole (PTZ)-induced seizures in rats by targeting inflammation and oxidative stress. ( Dolatshahi, M; Hashemi, P; Karimpour, S; Nazarinia, D, 2023) |
| "Cannabidiol (CBD) is the main active ingredient in the cannabis plant used for treating epilepsy and related diseases." | 4.31 | The Potential Mechanism of Cannabidiol (CBD) Treatment of Epilepsy in Pentetrazol (PTZ) Kindling Mice Uncovered by Multi-Omics Analysis. ( He, M; Jiang, X; Lu, H; Wang, Q; Wei, M; Zhao, Y, 2023) |
| "To investigate the efficacy and mechanisms of Dingxian pill combined with valproic acid (VPA) on pentylenetetrazol-induced chronical epilepsy in rats." | 4.31 | Efficacy and mechanisms of Dingxian pill combined with valproic acid on pentylenetetrazol-induced chronic epilepsy in rats. ( Dongxiao, QU; Guoyi, LI; Jie, T; Jiwei, C; Liji, C; Limin, Z; Qian, X; Yiqin, GE; Yonghua, X; Yudan, Z, 2023) |
| " In the present work, BCRP's role as a mechanism that might contribute to drug-resistant epilepsy (DRE) in a mouse model of acute seizures was studied with further assessment of the effect of its inhibition by ko143 and metformin (MET) on lamotrigine (LTG) bioavailability and efficacy." | 4.31 | Implications of BCRP modulation on PTZ-induced seizures in mice: Role of ko143 and metformin as adjuvants to lamotrigine. ( El-Sayed, NS; Fathelbab, MH; Harby, SA; Khalil, NA; Saleh, SR; Thabet, EH, 2023) |
| " Inositols have proved effective in many disorders; hence, in the current study, we tested potential antiepileptic properties of scyllo-inositol (SCI)-one of the most common commercially available inositols-in zebrafish larvae with pentylenetetrazol-induced seizures." | 4.31 | Antiepileptic Properties of Scyllo-Inositol on Pentylenetetrazol-Induced Seizures. ( Antonowski, T; Juranek, J; Podlasz, P; Wiśniewski, K; Wojtkiewicz, J, 2023) |
| "Pentylenetetrazole (PTZ) was administered to induce seizures in a total number of 48 Sprague-Dawley rats." | 4.31 | N-acetyl cysteine: A new look at its effect on PTZ-induced convulsions. ( Azak Pazarlar, B; Bilister Egilmez, C; Erbas, O; Erdogan, MA, 2023) |
| " Hence, the methanol extract was further explored for its anticonvulsant potential in pentylenetetrazole (PTZ) induced acute seizures in mice." | 4.31 | Anticonvulsant potential of Grewia tiliaefolia in pentylenetetrazole induced epilepsy: insights from in vivo and in silico studies. ( Arora, S; Kaur, S; Kumar, N; Rajput, A; Sharma, P; Singh Bedi, PM; Singh, B; Singh, H; Singh, S; Singh, T, 2023) |
| "A common way to investigate epilepsy and the effect of antiepileptic pharmaceuticals is to analyze the movement patterns of zebrafish larvae treated with different convulsants like pentylenetetrazol (PTZ), pilocarpine, etc." | 4.31 | A comparative study to optimize experimental conditions of pentylenetetrazol and pilocarpine-induced epilepsy in zebrafish larvae. ( Aly, N; Budan, F; Dittrich, B; Gorbe, A; Jin, M; Sik, A; Szentpeteri, JL; Szep, D, 2023) |
| " Here, we conducted present study to evaluate its neuroprotective effects against pentylenetetrazole (PTZ)-induced seizures in rats." | 4.31 | (-)-α-bisabolol exerts neuroprotective effects against pentylenetetrazole-induced seizures in rats by targeting inflammation and oxidative stress. ( Hashemi, P; Moslehi, A; Nazarinia, D, 2023) |
| "Serotonin and fluoxetine, but not sumatriptan, alleviated PTZ-induced seizures by prolonging onset times of myoclonic-jerk and generalized tonic-clonic seizures." | 4.12 | Endogenous and exogenous serotonin, but not sumatriptan, ameliorate seizures and neuroinflammation in the pentylenetetrazole-induced seizure model in rats. ( Kilinc, E; Kılınc, YB; Torun, IE, 2022) |
| "Pentylenetetrazole (PTZ)-induced kindling is an animal model for studying human temporal lobe epilepsy (TLE), which is characterized by alterations of hippocampal neurons and memory." | 4.12 | Protective Effects of Intranasally Administrated Oxytocin-Loaded Nanoparticles on Pentylenetetrazole-Kindling Epilepsy in Terms of Seizure Severity, Memory, Neurogenesis, and Neuronal Damage. ( Emik, S; Sahin, H; Senturk, GE; Yucel, O, 2022) |
| " Here we examine the effects of valproic acid (VA) plus 4-phenylbutyric acid (4-PBA) on abnormal electrical brain activity, ER stress and apoptosis in acute seizures induced by pentylenetetrazole (PTZ)." | 4.12 | 4-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole. ( Amanvermez, R; Arslan, G; Gün, S; Rzayev, E; Tiryaki, ES, 2022) |
| "Pentylenetetrazole (PTZ) is preferred for experimental epilepsy induction." | 4.12 | The protective effect of vitamin U on pentylenetetrazole-induced brain damage in rats. ( Bayrak, G; Turkyilmaz, IB; Yanardag, R, 2022) |
| "Morin is a bioactive flavonoid with prominent neuroprotective potentials, however, its impact on epilepsy-provoked cognitive dysregulations has not been revealed." | 4.12 | Morin offsets PTZ-induced neuronal degeneration and cognitive decrements in rats: The modulation of TNF-α/TNFR-1/RIPK1,3/MLKL/PGAM5/Drp-1, IL-6/JAK2/STAT3/GFAP and Keap-1/Nrf-2/HO-1 trajectories. ( Abd El-Aal, SA; Abulfadl, YS; El-Abhar, HS, 2022) |
| " This study investigated the effects and mechanisms of compound 48/80-stimulated mast cell activation on pentylenetetrazole-induced epileptic seizures in rats." | 4.12 | Mast cell activation ameliorates pentylenetetrazole-induced seizures in rats: The potential role for serotonin. ( Cetinkaya, A; Kilinc, E; Tore, F; Torun, IE, 2022) |
| " OV329, a novel drug candidate for the treatment of epilepsy and addiction, has been shown in vitro to be substantially more potent as a GABA-AT inactivator than vigabatrin, an antiseizure drug approved as an add-on therapy for adult patients with refractory complex partial seizures and monotherapy for pediatric patients with infantile spasms." | 4.02 | OV329, a novel highly potent γ-aminobutyric acid aminotransferase inactivator, induces pronounced anticonvulsant effects in the pentylenetetrazole seizure threshold test and in amygdala-kindled rats. ( Deking, LS; During, MJ; Feja, M; Gernert, M; Kaczmarek, E; Meller, S; Silverman, RB, 2021) |
| "In spite of use of cannabidiol (CBD), a non-psychoactive cannabinoid, in pediatric patients with epilepsy, preclinical studies on its effects in immature animals are very limited." | 4.02 | Anticonvulsive Effects and Pharmacokinetic Profile of Cannabidiol (CBD) in the Pentylenetetrazol (PTZ) or N-Methyl-D-Aspartate (NMDA) Models of Seizures in Infantile Rats. ( Hložek, T; Kubová, H; Mareš, P; Páleníček, T; Uttl, L, 2021) |
| " In the pharmacodynamic interaction study, seizures were induced using pentylenetetrazole (PTZ) (60 mg/kg, i." | 4.02 | Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats. ( Agarwal, A; Arora, R; Ganeshan N, S; Gupta, YK; Kaleekal, T; Kumar, R; Sarangi, SC, 2021) |
| "The primary cause of seizure-induced death for all mice was apnea, as (1) apnea began during a seizure and continued for tens of minutes until terminal asystole, and (2) death was prevented by mechanical ventilation." | 4.02 | Postictal Death Is Associated with Tonic Phase Apnea in a Mouse Model of Sudden Unexpected Death in Epilepsy. ( Blizzard, EA; Goodkin, HP; Meisler, MH; Panchal, PS; Patel, MK; Richerson, GB; Saraf, P; Teran, FA; Wagley, PK; Wagnon, JL; Wengert, ER; Wenker, IC, 2021) |
| " The study looked at how the thiamine supplement impacted pentylenetetrazole (PTZ)-induced seizures in rats and pentylenetetrazole-induced neurotoxicity in the SH-SY5Y cell line." | 4.02 | The modulator action of thiamine against pentylenetetrazole-induced seizures, apoptosis, nitric oxide, and oxidative stress in rats and SH-SY5Y neuronal cell line. ( Ergul, M; Taskiran, AS, 2021) |
| "A model of acute epilepsy in mice was established using the Pentylenetetrazol (PTZ) ignition method to evaluate the effects of Rhein on the duration and latency of convulsions, and the number and severity of seizures." | 4.02 | Rhein attenuates PTZ‑induced epilepsy and exerts neuroprotective activity via inhibition of the TLR4-NFκB signaling pathway. ( Cao, J; Li, X; Yang, J; Yu, L; Yu, W, 2021) |
| " Adaptation of zebrafish to study seizures was initially established using the common convulsant agent pentylenetetrazole (PTZ)." | 4.02 | A zebrafish-centric approach to antiepileptic drug development. ( Baraban, SC, 2021) |
| " We investigated effects of long-term probiotics supplementation on epileptic seizures, and inflammatory and oxidant/antioxidant biomarkers in a pentylenetetrazole(PTZ)-induced seizure model in rats." | 4.02 | Protective effects of long-term probiotic mixture supplementation against pentylenetetrazole-induced seizures, inflammation and oxidative stress in rats. ( Ankarali, H; Ankarali, S; Ayhan, D; Cetinkaya, A; Kilinc, E; Torun, IE, 2021) |
| " Importantly, the isobolographic analysis showed that a combination of AS-1 and valproic acid (VPA) at the fixed ratio of 1:1 displayed a supra-additive (synergistic) interaction against PTZ-induced seizures in mice." | 3.96 | N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum Antiepileptic Drug. ( Abram, M; Andres-Mach, M; Esguerra, CV; Gawel, K; Jakubiec, M; Kamiński, K; Latacz, G; Lubelska, A; Nieoczym, D; Pieróg, M; Rapacz, A; Socała, K; Szewczyk, A; Szulczyk, B; Wlaź, P; Zagaja, M; Łuszczki, JJ, 2020) |
| " In this study we show that low-dose intranasal insulin inhibited kainic acid (KA)- or pentylenetetrazole (PTZ)-induced acute seizures and reduced epileptic discharge activities in mice, potentially by alleviating the increase in seizure-induced glutamate in the hippocampus." | 3.96 | Low-dose intranasal insulin improves cognitive function and suppresses the development of epilepsy. ( Fan, Y; Hou, C; Jiang, G; Peng, S; Tang, F; Wang, X; Wang, Y; Yang, J; Yu, J, 2020) |
| " C11 revealed high efficacy in acute animal seizure models such as the maximal electroshock model (MES), the pentylenetetrazole model (PTZ) and the 6 Hz (6 Hz, 32 mA) seizure model, as well as in the kindling model of epilepsy induced by repeated injection of PTZ in mice." | 3.96 | Evaluation of the impact of compound C11 a new anticonvulsant candidate on cognitive functions and hippocampal neurogenesis in mouse brain. ( Abram, M; Andres-Mach, M; Kaminski, K; Luszczki, J; Maj, M; Rola, R; Szewczyk, A; Zagaja, M, 2020) |
| " Epilepsy-associated comorbid depression was evaluated by tail suspension test, sucrose preference test, and plasma corticosterone levels, whereas epilepsy-associated memory deficit condition was assessed by step-through paradigm, Morris water maze, and nitrite levels." | 3.96 | Exploring the ameliorative role of α7 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice. ( Goel, RK; Kaur, S; Sharma, NK, 2020) |
| "Epilepsy was induced in rats by injecting Pentylenetetrazole at 35 mg/kg every other day." | 3.96 | Glutamatergic pathway in depressive-like behavior associated with pentylenetetrazole rat model of epilepsy with history of prolonged febrile seizures. ( Alese, OO; Mabandla, MV; Mkhize, NV; Ngoupaye, GT; Rakgantsho, C; Zulu, S, 2020) |
| " This study aimed to investigate the effect of sCT on epileptic seizures, epileptogenesis, and postseizure hippocampal neuronal damage in pentylenetetrazole (PTZ)-induced epilepsy model in rats." | 3.96 | The effects of salmon calcitonin on epileptic seizures, epileptogenesis, and postseizure hippocampal neuronal damage in pentylenetetrazole-induced epilepsy model in rats. ( Ergul, M; Gumus, E; Ozdemir, E; Taskıran, AS, 2020) |
| " In the earlier work, 2-propanone-1,3,5,5-trimethyl-2-cyclohexen-1-ylidine demonstrated anticonvulsant activity against pentylenetetrazole (PTZ)-induced seizures." | 3.96 | In vivo anticonvulsant activity of 2-propanone-1,3,5,5-trimethyl-2-cyclohexen-1-ylidine in pilocarpine and strychnine induced-seizure models. ( Askani, M; Malhi, SM; Nisar, U; Shaheen, F; Shahid, M; Simjee, SU, 2020) |
| " The chronic model of epilepsy was developed by intraperitoneal injection of pentylenetetrazole (PTZ) at dose of 36." | 3.91 | Fabrication and evaluation of novel quercetin-conjugated Fe ( Ahmadian, SR; Akbari, A; Ghasemi, S; Ghasemi-Kasman, M; Hashemian, M; Moalem-Banhangi, M; Zare, L, 2019) |
| " The agents tested were: alpha-lactoalbumin (ALAC), a whey protein rich in tryptophan, effective in some animal models of epilepsy and on colon/intestine inflammation, valproic acid (VPA), an effective antiepileptic drug in this seizure model, mesalazine (MSZ) an effective aminosalicylate anti-inflammatory treatment against ulcerative colitis and sodium butyrate (NaB), a short chain fatty acid (SCFA) normally produced in the intestine by gut microbiota, important in maintaining gut health and reducing gut inflammation and oxidative stress." | 3.91 | Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy. ( Avagliano, C; Calignano, A; Citraro, R; Constanti, A; De Caro, C; De Sarro, G; di Cesare Mannelli, L; Ghelardini, C; Leo, A; Mainardi, P; Nesci, V; Russo, E; Striano, P, 2019) |
| " This study evaluated the efficacy of sodium valproate encapsulated in nanoparticles in pentylenetetrazole (PTZ) induced acute and kindling models of seizures in male Wistar rats." | 3.91 | Evaluation of sodium valproate loaded nanoparticles in acute and chronic pentylenetetrazole induced seizure models. ( Dinda, AK; Gupta, YK; Kottarath, SK; Meenu, M; Reeta, KH, 2019) |
| " The present study was designed to investigate the effect of acute and chronic administration of thiamine alone and in combination with sub-effective dose of diazepam on pentylenetetrazole (PTZ)-induced tonic-clonic seizures in mice." | 3.91 | Anticonvulsant effects of thiamine on pentylenetetrazole-induced seizure in mice. ( Abed, A; Alinejad, M; Banafshe, HR; Heydari, A; Mesdaghinia, A, 2019) |
| "The present study was designed to examine the possible neuroprotective and antiepileptic effects of metformin (Metf) in a rat model of pentylenetetrazole (PTZ)-induced epilepsy and its possible underlying mechanisms." | 3.91 | Effects of metformin on apoptosis and α-synuclein in a rat model of pentylenetetrazole-induced epilepsy. ( Abbas, KM; Abulseoud, OA; Ali, AN; El-Mesery, M; El-Shafey, M; Eldosoky, M; Hussein, AM, 2019) |
| " The present study was designed to evaluate the effect of arbutin supplementation on seizures behavior, memory performance, glial activation, release of inflammatory factors and neuroprotection in pentylenetetrazole-induced kindling model." | 3.91 | Arbutin attenuates cognitive impairment and inflammatory response in pentylenetetrazol-induced kindling model of epilepsy. ( Ahmadian, SR; Ghasemi-Kasman, M; Pouramir, M; Sadeghi, F, 2019) |
| "The effects of edaravone against pentylenetetrazole (PTZ)-induced epilepsy in male albino rats were investigated." | 3.91 | Edaravone acts as a potential therapeutic drug against pentylenetetrazole-induced epilepsy in male albino rats by downregulating cyclooxygenase-II. ( Liu, LM; Lu, Y; Wang, N; Wang, WP, 2019) |
| " Pentylenetetrazole- (PTZ) and pilocarpine-induced seizures are well-established models of human epilepsy." | 3.91 | The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure. ( Jand, A; Mousavi-Hasanzadeh, M; Palizvan, MR; Rezaeian-Varmaziar, H; Shafaat, O, 2019) |
| " Although it has been reported that AM404, a metabolite of acetaminophen, has anticonvulsant effects in several animal seizure models, little is known about the relation between acetaminophen and seizures." | 3.88 | Anticonvulsant effects of acetaminophen in mice: Comparison with the effects of nonsteroidal anti-inflammatory drugs. ( Araki, H; Aso, H; Suemaru, K; Tanaka, A; Watanabe, M; Yoshikawa, M, 2018) |
| " Here, we investigated whether embryonic exposure to ethanol can increase the susceptibility to pentylenetetrazole (PTZ)-induced seizures in larval zebrafish." | 3.88 | Embryonic exposure to ethanol increases the susceptibility of larval zebrafish to chemically induced seizures. ( Cai, L; Chen, SY; Chen, X; Feng, W; Liu, J; Wang, K; Wu, X; Zou, LP, 2018) |
| " Therefore, hippocampal Pol1 activity was examined in mouse models of epilepsy including kainic acid- and pilocarpine-induced status epilepticus (SE) as well as a single seizure in response to pentylenetetrazole (PTZ)." | 3.88 | RNA Polymerase 1 Is Transiently Regulated by Seizures and Plays a Role in a Pharmacological Kindling Model of Epilepsy. ( Hetman, M; Kolikonda, M; Naik, SP; Parlato, R; Pietrzak, M; Slomnicki, LP; Smith, SC; Vashishta, A, 2018) |
| " The aim of this study was to evaluate the effects of corilagin, an ellagitannin extracted from medicinal plants, on the frequency of seizures and cognitive function in a rat model of chronic epilepsy." | 3.88 | Corilagin Reduces the Frequency of Seizures and Improves Cognitive Function in a Rat Model of Chronic Epilepsy. ( Chang, LY; Wei, LL; Yu, H; Yu, X; Zhou, T, 2018) |
| ") to pentylenetetrazole-induced kindling in rats (a model of human epilepsy)." | 3.88 | Pharmacological Evaluation of Novel Flavone from Morus alba in Pentylenetetrazole-Induced Kindling and Oxidative Stress. ( Chinnaboina, GK; Gupta, G; Mishra, A; Singh, M; Veerabhadrappa, KVS; Wang, B, 2018) |
| "The chronic epilepsy model was established by pentylenetetrazole (PTZ) kindling." | 3.88 | Sinomenine exerts anticonvulsant profile and neuroprotective activity in pentylenetetrazole kindled rats: involvement of inhibition of NLRP1 inflammasome. ( Dong, K; Gao, B; Huang, DK; Li, WZ; Wu, WN; Wu, Y; Yang, YJ; Yin, YY; Zhou, J, 2018) |
| " All rats except those from the sham group were treated with PTZ to establish temporal lobe epilepsy (TLE) models, whereas the P38 MAPK inhibitor SB 203580 was given to the inhibitor group." | 3.85 | P38 MAPK pathway mediates cognitive damage in pentylenetetrazole-induced epilepsy via apoptosis cascade. ( Huang, Q; Huang, Y; Liao, Y; Liu, X; Ma, M; Wei, X; Wu, Y, 2017) |
| "In view of well-evidenced antiepileptic effects of melatonin and few reports of anticonvulsant action of agomelatine, the present study investigated whether agomelatine protects against pentylenetetrazole (PTZ)-induced kindling in mice and kindling-associated oxidative stress, depression, and impairment of spatial memory." | 3.85 | Effects of agomelatine on pentylenetetrazole-induced kindling, kindling-associated oxidative stress, and behavioral despair in mice and modulation of its actions by luzindole and 1-(m-chlorophenyl) piperazine. ( Agarwal, NB; Azim, MS; Vohora, D, 2017) |
| " The effects of TNS (3-hour session; 30-s ON, 5-min OFF; 30Hz; 500μs; 2mA) were evaluated on: (i) behavioral pattern of pentylenetetrazole (PTZ)-induced seizures as measured by the Racine scale; (ii) c-Fos-like immunoreactivity in discrete brain areas; (iii) hippocampal cell proliferation by bromodeoxyuridine (BrdU)-like immunoreactivity." | 3.85 | Trigeminal nerve stimulation induces Fos immunoreactivity in selected brain regions, increases hippocampal cell proliferation and reduces seizure severity in rats. ( Boi, M; Deriu, F; Enrico, P; Floris, G; Follesa, P; Mercante, B; Quartu, M; Serra, MP, 2017) |
| " Does GHRH enhance the inhibitory effect of GABA to prevent epilepsy by increasing the GABA level and activating GABARs? In this study, patients with epilepsy and C57/BL6 mice with epilepsy induced by kainic acid (KA) or pentylenetetrazol (PTZ) served as the research subjects." | 3.85 | Interactions between GHRH and GABAARs in the brains of patients with epilepsy and in animal models of epilepsy. ( Huang, H; Lu, X; Luo, Z; Qiu, X; Tang, S; Xu, Z; Zhang, Y, 2017) |
| " Ferulic acid is a phenolic phytochemical with antioxidant and neuroprotective properties that prompted us to evaluate its therapeutic potential in epilepsy which is usually associated with oxidative stress and cognitive decline." | 3.85 | Ferulic acid exhibits antiepileptogenic effect and prevents oxidative stress and cognitive impairment in the kindling model of epilepsy. ( Arbabi, E; Atyabi, F; Dinarvand, R; Hassanzadeh, P, 2017) |
| " Anticonvulsant activity was tested against clonic seizures induced by pentylenetetrazole (PTZ, 60 mg/kg, i." | 3.85 | In silico Screening and Evaluation of the Anticonvulsant Activity of Docosahexaenoic Acid-Like Molecules in Experimental Models of Seizures. ( Gharibi Loron, A; Narenjkar, J; Sardari, S; Sayyah, M, 2017) |
| " Owing to the major role of neuronal nitric oxide synthase (nNOS) in brain and ineffectiveness of antiepileptic drugs (AEDs) in restoring nitrosative stress, the present study was envisaged to evaluate the adjuvant nNOS inhibitor, 7-nitroindazole (7-NI) with valproic acid for combined treatment of epilepsy and associated depression." | 3.85 | Adjuvant neuronal nitric oxide synthase inhibition for combined treatment of epilepsy and comorbid depression. ( Goel, RK; Singh, T, 2017) |
| " The rats were decapitated at the 24th or 72nd hour of seizures and brain tissues were obtained for histopathological examination and for measuring levels of malondialdehyde (MDA), glutathione (GSH), reactive oxygen radicals and myeloperoxidase (MPO) activity." | 3.85 | Obestatin improves oxidative brain damage and memory dysfunction in rats induced with an epileptic seizure. ( Akakın, D; Atal, SS; Kervancıoğlu Demirci, E; Koyuncuoğlu, T; Üren, D; Vızdıklar, C; Yeğen, BÇ; Yıldırım, Ç; Yılmaz, H; Yüksel, M, 2017) |
| " The present study was designed to investigate synergistic anticonvulsant effects of pregabalin with amlodipine on acute seizure model of epilepsy in mice." | 3.85 | Synergistic anticonvulsant effects of pregabalin and amlodipine on acute seizure model of epilepsy in mice. ( Khan, RA; Qureshi, IH; Riaz, A; Siddiqui, AA, 2017) |
| "Folic acid (FA) is physiologically important in mammals and is a common vitamin supplement used during pregnancy and lactation." | 3.83 | Gestational treatment of folic acid attenuates blood-brain barrier leakage in pregnant- and prepubertal rats after pentylenetetrazole-induced seizure. ( Caglayan, B; Kaptan, E; Oztas, B; Seker, FB; Yorulmaz, H, 2016) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 3.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| "The present study aimed to develop a neurochemistry-based single or adjuvant therapy approach for comprehensive management of epilepsy and associated depression employing pentylenetetrazole-kindled animals." | 3.83 | Evidence in support of using a neurochemistry approach to identify therapy for both epilepsy and associated depression. ( Goel, RK; Singh, T, 2016) |
| " Although efficacious, AMPA-receptor antagonists, including perampanel (Fycompa), the only approved antagonist for epilepsy, induce dizziness and motor impairment." | 3.83 | Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism. ( Bredt, DS; Burris, KD; Catlow, JT; Ding, C; Fitch, TE; Fitzjohn, SM; Gardinier, KM; Gernert, DL; Gleason, SD; Heinz, BA; Isaac, JT; Kato, AS; Lee, MR; Nisenbaum, ES; Ornstein, PL; Pasqui, F; Porter, WJ; Qian, Y; Rasmussen, K; Reel, J; Schober, DA; Sher, E; Tu, Y; Wafford, KA; Wang, H; Witkin, JM; Yu, H; Zwart, R, 2016) |
| "Pentylenetetrazol (PTZ)-induced chronic kindling model and lithium-pilocarpine-induced status epilepticus (SE) model were used in this study." | 3.81 | Degeneration and regeneration of GABAergic interneurons in the dentate gyrus of adult mice in experimental models of epilepsy. ( Jiang, W; Wang, Y; Wei, D; Wu, C; Wu, SX; Yang, F, 2015) |
| "Some doses of rosmarinic acid and CA tested showed neuroprotective action against oxidative and DNA damage produced in the kindling epilepsy model, although they did not produce antiepileptogenic effect in vivo." | 3.81 | Antiepileptogenic, antioxidant and genotoxic evaluation of rosmarinic acid and its metabolite caffeic acid in mice. ( Basso, C; Coelho, VR; de Souza, LP; Moysés, F; Papke, DK; Pereira, P; Picada, JN; Pires, TR; Siqueira, IR; Vieira, CG, 2015) |
| " This compound was effective in delaying onset of PTZ-evoked seizures at the dose of 5mg/kg in kindled animals and significantly reduced oxidative stress better than standard drug phenobarbital (PB)." | 3.81 | Design, synthesis and pharmacological evaluation of N-[4-(4-(alkyl/aryl/heteroaryl)-piperazin-1-yl)-phenyl]-carbamic acid ethyl ester derivatives as novel anticonvulsant agents. ( Kumari, S; Mishra, CB; Tiwari, M, 2015) |
| " We evaluated influence of DHA on anticonvulsant activity of AEDs phenytoin, valproate, and lamotrigine in maximal electroshock (MES), pentylenetetrazole (PTZ), and kindling models of epilepsy." | 3.81 | Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models. ( Babapour, V; Gavzan, H; Sardari, S; Sayyah, M, 2015) |
| "Epilepsy is a neurological disorder that has been associated with oxidative stress therefore epilepsy models have been develop such as kainic acid and pentylenetetrazol are usually used to understanding of the molecular mechanisms of this disease." | 3.81 | Metallothionein expression in the rat brain following KA and PTZ treatment. ( Díaz-Ruíz, A; Flores-Espinosa, P; Heras-Romero, Y; Juárez-Rebollar, D; Manjarrez, J; Méndez-Armenta, M; Nava-Ruíz, C; Zaga-Clavellina, V, 2015) |
| "There is considerable interest in using bumetanide, a chloride importer Na-K-Cl cotransporter antagonist, for treatment of neurological diseases, such as epilepsy or ischemic and traumatic brain injury, that may involve deranged cellular chloride homeostasis." | 3.80 | A novel prodrug-based strategy to increase effects of bumetanide in epilepsy. ( Brandt, C; Brunhofer, G; Erker, T; Feit, PW; Gabriel, M; Kaila, K; Lindfors, J; Löscher, W; Töllner, K; Töpfer, M, 2014) |
| "To explore the role of innate immunity in the mechanism of epilepsy, the pentylenetetrazole (PTZ) kindling rat model was established using intraperitoneal injection of PTZ." | 3.80 | Expression of SOCSs and TLRs in the hippocampus of pentylenetetrazole kindling model. ( Dang, J; Ding, DX; Huang, WJ; Liu, H; Song, MY; Tian, FF; Wang, YZ, 2014) |
| "The aims of this study were to characterize a lamotrigine-resistant kindled model of epilepsy in mice, to study the anticonvulsant effect of carbamazepine (CBZ) and valproic acid (VPA), and to probe into the mechanism for resistance." | 3.80 | Characterization of a lamotrigine-resistant kindled model of epilepsy in mice: evaluation of drug resistance mechanisms. ( Mehndiratta, M; Pillai, KK; Singh, E, 2014) |
| " Pentylenetetrazole (PTZ)-kindled and spontaneous model of epilepsy (EL) mice were used as models of chemically induced and spontaneous epilepsy, respectively." | 3.80 | Pharmacoproteomics-based reconstruction of in vivo P-glycoprotein function at blood-brain barrier and brain distribution of substrate verapamil in pentylenetetrazole-kindled epilepsy, spontaneous epilepsy, and phenytoin treatment models. ( Ohtsuki, S; Terasaki, T; Uchida, Y, 2014) |
| " Susceptibility to pentylenetetrazole-induced seizures was assessed by electrocorticography in head-restrained nonanesthetized rats." | 3.80 | Normotopic cortex is the major contributor to epilepsy in experimental double cortex. ( Buhler, E; Chauvin, Y; Jalabert, M; Malvache, A; Manent, JB; Peret, A; Petit, LF; Represa, A; Watrin, F, 2014) |
| "The present study was aimed to investigate the potential beneficial effect of curcumin, a polyphenol with pleiotropic properties, on mitochondrial dysfunctions, oxidative stress and cognitive deficits in a kindled model of epilepsy." | 3.80 | Curcumin supplementation improves mitochondrial and behavioral deficits in experimental model of chronic epilepsy. ( Bal, A; Kaur, H; Sandhir, R, 2014) |
| "These data indicate that MSCs were superior to gabapentin in ameliorating PTZ-induced epileptogenesis and verified the potential use of MSCs in seizure control, motor and cognitive impairments, oxidative stress, and the impairing GABA level in experimentally induced epilepsy." | 3.80 | Effects of intravenous human umbilical cord blood mesenchymal stem cell therapy versus gabapentin in pentylenetetrazole-induced chronic epilepsy in rats. ( Essawy, SS; Ewais, MM; Mohammed, AS; Tawfik, MK, 2014) |
| "Pentylenetetrazole (PTZ) is a widely-used convulsant used in studies of epilepsy; its subcutaneous injection generates an animal model with stable seizures." | 3.79 | BDNF-TrkB signaling pathway is involved in pentylenetetrazole-evoked progression of epileptiform activity in hippocampal neurons in anesthetized rats. ( Ding, J; Fan, W; Jin, LY; Liu, J; Liu, X; Liu, XL; Peng, LC; Wang, X; Wang, Y, 2013) |
| "The anticonvulsant effect of dicholine succinate (DCS), a neuronal insulin sensitizer, has been studied on two models of primary generalized epilepsy induced by corazole and maximal electroshock (ME) in mice." | 3.79 | [Anticonvulsant effect of dicholine succinate on primary generalized epilepsy model in mice]. ( Pomytkin, IA; Rychikhin, VM; Sariev, AK, 2013) |
| " (MQ) in maximal electroshock (MES) and pentylenetetrazole (PTZ) induced rat models of epilepsy." | 3.79 | Evaluation of anti-epileptic property of Marsilea quadrifolia Linn. in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy. ( Avinash, H; Chandrashekar, BR; Mukunda, N; Naduvil Narayanan, S; Nayak, BS; Raghavendra Rao, K; Sadhana, N; Satish Kumar, MC; Snehunsu, A; Vijay Kapgal, K, 2013) |
| " This new method documented that seizures in the zebrafish EAST model were ameliorated by pentobarbitone, but not diazepam, validating its usefulness." | 3.79 | Epilepsy in kcnj10 morphant zebrafish assessed with a novel method for long-term EEG recordings. ( Bockenhauer, D; Kleta, R; Mahmood, F; Russell, C; Stanescu, HC; Zdebik, AA, 2013) |
| " Thus, this study was carried out to evaluate the acute effect of liposome-entrapped curcumin on increasing current electroshock seizures (ICES) test, pentylenetetrazole (PTZ)-induced seizures, and status epilepticus in mice." | 3.79 | Liposomal formulation of curcumin attenuates seizures in different experimental models of epilepsy in mice. ( Agarwal, NB; Agarwal, NK; Jain, S; Mediratta, PK; Nagpal, D; Sharma, KK, 2013) |
| "We aimed to reveal the anti-convulsant effects of oxytocin (OT) in pentylenetetrazol (PTZ)-induced seizures in rats." | 3.79 | Oxytocin inhibits pentylentetrazol-induced seizures in the rat. ( Bora, S; Erbas, O; Evren, V; Korkmaz, HA; Peker, G; Yılmaz, M, 2013) |
| "Clinical reports have shown that some antihistamines, such as ketotifen, occasionally produced seizures, especially in pre-school age children or young patients with epilepsy." | 3.78 | The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats. ( Kanda, T; Takizawa, F; Tamura, T; Yamada, K, 2012) |
| "Wuling mycelia can delay the kindling and ameliorate the ability of learning in rats with pentylenetetrazole-induced epilepsy and the enhancement of neuronal histamine activity may be one of possible mechanisms." | 3.78 | [Effects of Wuling mycelia on pentylenetetrazole-induced epilepsy in rats]. ( Chen, GF; Hu, XY; Ren, GL; Zhang, LS, 2012) |
| "The effects of the halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine (3,5-DBr-D: -Tyr) were studied in rat models of stroke and epileptic seizures caused by middle cerebral artery occlusion (MCAo) through respective intracerebral injection of endothelin-1 (ET-1) and intraperitoneal (i." | 3.77 | Halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine produces beneficial effects in experimental stroke and seizures. ( Cao, W; Glushakov, A; Martynyuk, AE; Mecca, AP; Seubert, CN; Shah, HP; Shi, P; Sumners, C, 2011) |
| "The aim of present study was to examine the effects of the ethyl acetate fraction (EAF) from Platonia insignis on lipid peroxidation level, nitrite formation, and superoxide dismutase and catalase activities in rat striatum prior to pilocarpine-induced seizures as well as to explore its anticonvulsant activity in adult rats prior to pentylenetetrazole (PTZ)- and picrotoxin (PIC)-induced seizures." | 3.77 | Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models. ( Citó, AM; de Almeida, AA; de Freitas, RM; Júnior, JS; Saffi, J; Tomé, Ada R, 2011) |
| " The extract was submitted to a screening in anticonvulsant assays including NMDA-, kainic acid (KA)-, pentylenetetrazol (PTZ)- and bicuculline (BIC)-induced seizures in rats." | 3.76 | Anticonvulsant effects of Searsia dentata (Anacardiaceae) leaf extract in rats. ( Baldwin, RA; Jäger, AK; Niquet, J; Pedersen, ME; Stafford, GI; van Staden, J; Wasterlain, CG, 2010) |
| "The DNS II acetone fraction of Delphinium nordhagenii has exhibited the anticonvulsant actions by preventing the seizures against PTZ- and picrotoxin-induced seizure as well as 100% seizure protection in MES test." | 3.76 | Anticonvulsant activity of DNS II fraction in the acute seizure models. ( Ahmad, M; Raza, ML; Shaheen, F; Simjee, SU; Zeeshan, M, 2010) |
| "Exposing Sprague-Dawley rat pups to very low, sub-convulsant doses of domoic acid (DOM) during perinatal development has been previously shown to result in seizure-like activity in adulthood similar to partial complex epilepsy in humans, and to produce cellular and molecular changes in the dentate gyrus and area CA-3 of the hippocampus." | 3.76 | Neonatal exposure to low-dose domoic acid lowers seizure threshold in adult rats. ( Bastlund, JF; Gill, DA; Reynolds, DS; Ryan, CL; Tasker, RA; Watson, WP, 2010) |
| "Free radicals and selenium (Se) deficiency are involved in pathogenesis of epilepsy." | 3.75 | Effects of selenium and topiramate on lipid peroxidation and antioxidant vitamin levels in blood of pentylentetrazol-induced epileptic rats. ( Celik, O; Kutluhan, S; Naziroğlu, M; Yilmaz, M, 2009) |
| " Topiramate, a voltage-gated calcium channel inhibitor, has an evident effect in the treatment of childhood epilepsy; however, topiramate may cause nephrotoxicity." | 3.74 | Topiramate and vitamin e modulate antioxidant enzyme activities, nitric oxide and lipid peroxidation levels in pentylenetetrazol-induced nephrotoxicity in rats. ( Armagan, A; Bülbül, M; Kutluhan, S; Naziroglu, M; Soyupek, S; Vural, H; Yilmaz, M; Yilmaz, N, 2008) |
| "To characterize the type of interactions between vigabatrin (VGB) and tiagabine (TGB) -- two newer antiepileptic drugs influencing GABA-ergic neurotransmitter system, the isobolographic analysis was used in two experimental models of epilepsy: the maximal electroshock seizure threshold (MEST) test and pentylenetetrazole (PTZ)-induced seizures in mice." | 3.74 | Isobolographic characterization of interactions between vigabatrin and tiagabine in two experimental models of epilepsy. ( Czuczwar, SJ; Luszczki, JJ, 2007) |
| "This paper comprises a series of experiments in rodent models of partial and generalized epilepsy which were designed to describe the anti-convulsant profile of the functionalized amino acid lacosamide." | 3.74 | Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy. ( Choi, D; Harris, RH; Kohn, H; Kupferberg, HJ; Stables, JP; Stöhr, T; Walton, N; White, HS, 2007) |
| " With this background, the present study was designed to explore the possible effect of nimesulide (a preferential COX-2 inhibitor) against pentylenetetrazol (PTZ)-induced kindling epilepsy in mice." | 3.74 | Neuroprotective effect of nimesulide, a preferential COX-2 inhibitor, against pentylenetetrazol (PTZ)-induced chemical kindling and associated biochemical parameters in mice. ( Dhir, A; Kulkarni, SK; Naidu, PS, 2007) |
| "On the basis of epileptic model induced by pentylenetetrazol (PTZ), cognitive impairment model was induced by kindling epilepsy with PTZ everyday, which were then di-vided into the model-1 group, the CZD-1 group, the nimodipine-1 group, and those by injecting large dosage phenytoin sodium were divided into the model-2 group, the CZD-2 group and the nimodipine-2 group." | 3.74 | [Influence of repeated seizures and large dosage anti-epileptic drug on phosphorylated cAMP response element binding protein in rat's hippocampus and effect of Caoguo Zhimu Decoction]. ( He, J; Ma, SL, 2007) |
| "To determine the changes of mossy fiber sprouting in hippocampus of pre-kindling and post-kindling rats of chronic epilepsy induced by pentylenetetrazole (PTZ)." | 3.74 | [Changes of mossy fiber sprouting in hippocampus of pentylenetetrazole kindling rats]. ( Cai, XF; Chen, JM; Guo, TH; Ma, YF; Tian, FF; Yao, FH, 2007) |
| "The long-term effect of three of the most widely used antiepileptic drugs at relevant doses on the hearing decline that accompanies pentylenetetrazole (PTZ)-induced experimental epilepsy was investigated here, and compared with the effect of vinpocetine (VPC), which is a drug with antiepileptic potential." | 3.73 | Additive effects of antiepileptic drugs and pentylenetetrazole on hearing. ( Nekrassov, V; Sitges, M, 2006) |
| "To investigate the mechanisms of memory impairment induced by pentylenetetrazole (PTZ)-kindled epilepsy in rats and the effects of endogenous histamine." | 3.73 | [Effects of endogenous histamine on memory impairment induced by pentylenetetrazole-kindled epilepsy in rats]. ( Li, Q; Ma, YY; Zhang, LS, 2006) |
| "The study investigated the activity of harmane on maximal electroshock seizures (MES) and seizures induced by pentilentetrazole (PTZ) in mice." | 3.72 | Effect of harmane on the convulsive threshold in epilepsy models in mice. ( Aricioglu, F; Berkman, K; Korcegez, E; Yillar, O, 2003) |
| "To investigate the mechanisms of histamine on chronic epilepsy induced by pentylenetetrazole (PTZ)." | 3.72 | [Mechanisms of the effect of brain histamine on chronic epilepsy induced by pentylenetetrazole]. ( Chen, Z; Hu, WW; Jin, CL; Shen, HQ; Zhang, LS; Zhao, MH, 2004) |
| " In a prospective trial in dogs with newly diagnosed epilepsy, ELB 138 markedly reduced seizure frequency and severity without significant difference to standard treatments (phenobarbital or primidone) but was much better tolerated than the standard drugs." | 3.72 | Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures. ( Löscher, W; Potschka, H; Rieck, S; Rundfeldt, C; Tipold, A, 2004) |
| "A 10 mmol/kg injection of acetone suppressed seizures in 60% of rats (P<0." | 3.71 | Ketogenic diet: does acetone stop seizures? ( Burnham, WM; Likhodii, SS, 2002) |
| "Perimenstrual catamenial epilepsy may in part be due to withdrawal of the endogenous progesterone-derived neurosteroid allopregnanolone that potentiates gamma-aminobutyric acidA (GABA(A)) receptor-mediated inhibition." | 3.71 | Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2001) |
| "Perimenstrual catamenial epilepsy, the increase in seizure frequency that some women with epilepsy experience near the time of menstruation, may in part be related to withdrawal of the progesterone metabolite allopregnanolone, an endogenous anticonvulsant neurosteroid that is a potent positive allosteric gamma-aminobutyric acidA (GABA(A)) receptor modulator." | 3.71 | Neurosteroid withdrawal model of perimenstrual catamenial epilepsy. ( Kim, HY; Reddy, DS; Rogawski, MA, 2001) |
| "In mice VGD afforded complete protection against maximal electroshock (MES)-, pentylenetetrazole-, picrotoxin-, and bicuculline-induced seizures and 6-Hz "psychomotor" seizures with median effective dose (ED50) values of 151, 132, 275, 248, and 237 mg/kg, respectively." | 3.71 | Anticonvulsant profile of valrocemide (TV1901): a new antiepileptic drug. ( Bialer, M; Isoherranen, N; White, HS; Woodhead, JH, 2001) |
| "This work describes a novel epilepsy model, combining pentylenetetrazole (PTZ) kindling with the senescence-accelerated mouse P8 (SAMP8) a model for aging." | 3.71 | The pentylenetetrazole-kindling model of epilepsy in SAMP8 mice: behavior and metabolism. ( Bidar, A; Kondziella, D; Sletvold, O; Sonnewald, U; Urfjell, B, 2002) |
| "The anticonvulsive activity of nociceptin, endogenous OP4 receptors agonist was investigated in pentylenetetrazole (PTZ), N-methyl D-aspartic acid (NMDA), bicucculine (BCC) and electrically evoked seizure models of experimental epilepsy." | 3.71 | Nociceptin, OP4 receptor ligand in different models of experimental epilepsy. ( Gustaw, K; Rubaj, A; Sieklucka-Dziuba, M; Zgodzinski, W, 2002) |
| "In mice, M-TMCD afforded protection against maximal electroshock (MES)-induced, pentylenetetrazol (Metrazol)-induced, and bicuculline-induced seizures, as well as against 6-Hz "psychomotor" seizures and sound-induced seizures with ED50 values of 99, 39, 81, 51, and 10 mg/kg, respectively." | 3.71 | Anticonvulsant profile and teratogenicity of N-methyl-tetramethylcyclopropyl carboxamide: a new antiepileptic drug. ( Barton, ME; Bennett, GD; Bialer, M; Finnell, RH; Isoherranen, N; White, HS; Wilcox, KS; Woodhead, JH; Yagen, B, 2002) |
| "The protective and adverse effect potentials of levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide) in rodent models of seizures and epilepsy were compared with the profile of several currently prescribed and newly developed antiepileptic drugs." | 3.70 | Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. ( Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E, 1998) |
| "The purpose of this study was to test the hypothesis that a ketogenic diet would increase the resistance of rats to pentylenetetrazole (PTZ)-induced seizures and to understand the relation of ketonemia to seizure resistance." | 3.70 | A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat. ( Bough, KJ; Eagles, DA, 1999) |
| ") administration, were studied against audiogenic seizures in genetically epilepsy-prone rats (GEPRs) or pentylenetetrazole induced kindling in rats." | 3.70 | Effects of some AMPA receptor antagonists on the development of tolerance in epilepsy-prone rats and in pentylenetetrazole kindled rats. ( De Sarro, A; De Sarro, G; Di Paola, ED; Gallelli, L; Gareri, P; Scotto, G, 1999) |
| "We tested the sensitivity of PrPc knockout mice to seizures induced by single convulsant or repeated subconvulsant (kindling) doses of pentylenetetrazol (PTZ), and to status epilepticus (SE) induced by kainic acid or pilocarpine." | 3.70 | Increased sensitivity to seizures in mice lacking cellular prion protein. ( Amaral, OB; Brentani, RR; Cavalheiro, EA; Izquierdo, I; Martins, VR; Rockenbach, IC; Roesler, R; Walz, R, 1999) |
| "Perimenstrual catamenial epilepsy, the exacerbation of seizures in association with menstruation, may in part be due to withdrawal of the progesterone metabolite allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), an endogenous anticonvulsant neurosteroid that is a positive allosteric modulator of gamma-aminobutyric acid(A) receptors." | 3.70 | Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2000) |
| " A nearly fivefold elevation in NO content was found at the peak time of pentylenetetrazole (PTZ)-induced seizures." | 3.70 | Nitric oxide content measured by ESR-spectroscopy in the rat brain is increased during pentylenetetrazole-induced seizures. ( Bashkatova, V; Mikoyan, V; Narkevich, V; Rayevsky, K; Vanin, A; Vitskova, G, 2000) |
| " In addition, the plant extract delayed the onset of PTZ forelimb clonus, and generalized limbic seizures induced by kainic acid." | 3.69 | Effects of an ethanolic extract of Desmodium adscendens on central nervous system in rodents. ( Baldy-Moulinier, M; N'gouemo, P; Nguemby-Bina, C, 1996) |
| "Tolerance to the anticonvulsant effects of clobazam has been studied in three murine models of epilepsy: pentylenetetrazole- and N-methyl-D,L-aspartic acid-induced seizures and audiogenic-induced seizures in the DBA/2 strain." | 3.68 | Tolerance to the anticonvulsant effects of clobazam in mice. ( Pleuvry, BJ; Wildin, JD, 1992) |
| "In gerbils pentylenetetrazole- or handling-induced seizures were accompanied by cerebral formation of small amounts of cysteinyl-leukotrienes (LT) but large amounts of prostaglandin (PG) F2 alpha." | 3.68 | On the relation between cerebral cysteinyl-leukotriene formation and epileptic seizures. ( Simmet, T; Tippler, B, 1991) |
| "The anticonvulsant potency of 2-propyl-2-pentenoic acid (2-en-VPA; trans isomer), a major metabolite of the antiepileptic valproic acid (VPA), was evaluated in different animal models of epilepsy and compared with the respective data for VPA." | 3.67 | Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy. ( Löscher, W; Marescaux, C; Nau, H; Vergnes, M, 1984) |
| "In patients with suspected epilepsy, an EEG "activation" with bemegride can be performed as last link of the diagnostic chain." | 3.67 | [EEG activation with bemegride in epilepsy diagnosis. 1: Literature review]. ( Bülau, P; Fröscher, W, 1984) |
| "The seizure sensitive Mongolian gerbil, a genetic model of epilepsy, has been used to investigate the effects of prior spontaneous seizures on the threshold for pentylenetetrazole (PTZ) and maximum electroshock (MES) induced convulsions." | 3.67 | The effect of spontaneous seizures on pentylenetetrazole and maximum electroshock induced seizures in the Mongolian gerbil. ( Lee, RJ; Lomax, P, 1984) |
| "In rabbits subjected to bicuculline (BC)- or pentylenetetrazole (PTZ)-seizures of 3 or 20 min duration or to adrenaline-induced hypertension, specific gravity (SG) was measured bilaterally in 15 regional brain areas in order to detect possible associations between the regionally limited blood-brain barrier openings due to these insults (see Nitsch and Klatzo 1983) and the presence of brain edema." | 3.67 | Specific gravity increases and brain water content decreases during short epileptiform seizures in discrete rabbit brain areas. ( Fujiwara, K; Klatzo, I; Kuroiwa, T; Nitsch, C, 1984) |
| "The involvement of intranigral gamma-aminobutyric acid (GABA) receptors in the control of generalized non-convulsive epilepsy was investigated in the rat in 3 models of petit mal epilepsy induced by systemic administration of gamma-butyrolactone, pentylenetetrazol and 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridin 3-ol (THIP)." | 3.67 | Suppressive effects of intranigral injection of muscimol in three models of generalized non-convulsive epilepsy induced by chemical agents. ( Depaulis, A; Marescaux, C; Snead, OC; Vergnes, M, 1989) |
| "The neuropeptides somatostatin and neuropeptide Y and the activity of glutamate decarboxylase were determined in the frontal cortex of rats subjected to experimental epilepsy." | 3.67 | Concomitant increase of somatostatin, neuropeptide Y and glutamate decarboxylase in the frontal cortex of rats with decreased seizure threshold. ( Marksteiner, J; Sperk, G, 1988) |
| "Blood-brain barrier (BBB) permeability to macromolecules was assessed during seizures induced by pentylenetetrazole, bicuculline, methoxypyridoxine, methionine sulfoximine, and kainic acid." | 3.67 | Pathophysiological aspects of blood-brain barrier permeability in epileptic seizures. ( Goping, G; Klatzo, I; Nitsch, C, 1986) |
| "The results of surgical treatment of intractable epilepsy seizures in a group of patients investigated with the intracarotid amobarbital-pentylenetetrazol EEG test were analyzed." | 3.65 | Role of the intracarotid amobarbital-pentylenetetrazol EEG test in the diagnosis and surgical treatment of patients with complex seizure problems. ( Altuzarra, A; Garretson, H; Gloor, P; Rasmussen, T, 1976) |
| "Epilepsy is a neurological disorder affecting both children and adults, and many aspects of this disease are still poorly understood." | 3.01 | Zebrafish as an Innovative Tool for Epilepsy Modeling: State of the Art and Potential Future Directions. ( D'Amora, M; De Angelis, F; Faraguna, U; Galgani, A; Giorgi, FS; Marchese, M; Tantussi, F, 2023) |
| "The main outcomes assessed were seizure scores and locomotion." | 3.01 | Chemically-induced epileptic seizures in zebrafish: A systematic review. ( Benvenutti, R; Calcagnotto, ME; Chitolina, R; Gallas-Lopes, M; Herrmann, AP; Piato, A; Reis, CG; Stahlhofer-Buss, T, 2023) |
| " Consequently, the aim of the current study was to comparatively evaluate the pharmacokinetic (PK) and pharmacodynamic (PD anticonvulsant activity) profile of EMC and IPC individual enantiomers." | 2.79 | Enantioselective pharmacodynamic and pharmacokinetic analysis of two chiral CNS-active carbamate derivatives of valproic acid. ( Bialer, M; Finnell, RH; Mawasi, H; McDonough, JH; Shekh-Ahmad, T; Wlodarczyk, BJ; Yavin, E, 2014) |
| "Since 1993, over 20 new anti-seizure drugs (ASDs) have been identified in well-established animal seizure and epilepsy models and subsequently demonstrated to be clinically effective in double-blinded, placebo-controlled clinical trials in patients with focal onset seizures." | 2.66 | Validated animal models for antiseizure drug (ASD) discovery: Advantages and potential pitfalls in ASD screening. ( Barker-Haliski, M; Steve White, H, 2020) |
| "Patients with epilepsy are often affected by not only seizures but also a variety of cognitive and psychiatric comorbidities that further impair their quality of life." | 2.61 | [Neurobehavioral Comorbidities in Pentylenetetrazol-kindled Mice and Role of the α4β2 Nicotinic Acetylcholine Receptor]. ( Takechi, K, 2019) |
| "Epilepsy is characterized by recurrent seizures, which are caused by excessive discharges from cerebral neurons." | 2.48 | [Impaired memory following repeated pentylenetetrazol treatments in kindled mice]. ( Araki, H; Kawasaki, H; Suemaru, K; Takechi, K, 2012) |
| "Furthermore, testosterone's antiseizure effects may involve actions of its 5alpha-reduced metabolite and neuroactive steroid, 5alpha-androstane-3alpha,17beta-diol (3alpha-diol)." | 2.42 | Androgens in the hippocampus can alter, and be altered by, ictal activity. ( Frye, CA; Rhodes, ME, 2004) |
| "GABA related drugs acting on PTZ clonic seizures tend to induce sedation and muscle hypotonia." | 2.41 | Do preclinical seizure models preselect certain adverse effects of antiepileptic drugs. ( Meldrum, B, 2002) |
| "Epilepsy is a common neurological disorder affecting more than 70 million people worldwide." | 1.91 | ( Gao, Y; Jiang, X; Liang, X; Liu, W; Lu, H; Wang, N; Xing, B; Xu, X; Zhao, Q; Zhou, L, 2023) |
| "Liraglutide is a glucagon-like peptide-1 (GLP-1) analogue that is used to treat type-2 diabetes mellitus." | 1.91 | The Anti-Seizure Effect of Liraglutide on Ptz-Induced Convulsions Through its Anti-Oxidant and Anti-Inflammatory Properties. ( Erbas, O; Erdogan, A; Erdogan, MA, 2023) |
| "PTZ gradually provoked seizure-related behaviors." | 1.91 | The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure. ( Abnous, K; Gorji Valokola, M; Heydari, FS; Mehri, S; Roohbakhsh, A, 2023) |
| "Epilepsy is a disease which affects between 1 and 2% of the population, and a large proportion of these people do not react to currently available anticonvulsant medications, indicating the need for further research into novel pharmacological therapies." | 1.91 | Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions. ( Erbas, O; Erdogan, A; Erdogan, MA; Gurgul, S, 2023) |
| "Nocturnal epilepsy is a neurological disease that has a significant effect on sleep." | 1.91 | Effect of valproate on sleep patterns disturbed by epilepsy. ( Ayala-Guerrero, F; Castro-Domínguez, D; Gutiérrez-Chávez, CA; Mateos-Salgado, EL; Mexicano-Medina, G, 2023) |
| "Early onset of PTZ-induced seizure-like behavioural scores, the heightened intensity of seizure and reduced latency in different scores were found in PG and CPFX-administered groups." | 1.91 | Antibiotics modulate frequency and early generation of epileptic seizures in zebrafish. ( Ramachandran, B; Sivarajan, D, 2023) |
| "Chronic epilepsy was established in mice by giving PTZ (35 mg/kg, i." | 1.91 | Neuroprotection impact of biochanin A against pentylenetetrazol-kindled mice: Targeting NLRP3 inflammasome/TXNIP pathway and autophagy modulation. ( Abd El-Haleim, EA; El-Sayed, RM; Fawzy, MN; Zaki, HF, 2023) |
| "Epilepsy is characterized by the manifestation of spontaneous and recurrent seizures." | 1.91 | The Effect of Adenosine Signaling on Memory Impairment Induced by Pentylenetetrazole in Zebrafish. ( Bertoncello, KT; Bonan, CD, 2023) |
| "Inflammation is considered to be involved in epileptogenesis." | 1.91 | Inflammation as a target for the treatment of fever-associated epilepsy in zebrafish larvae. ( Liang, W; Shen, D; Shen, Y; Sui, J; Wang, J; Wu, Y; Yun, F; Zhang, Q; Zhou, J, 2023) |
| "Tacrolimus pre-treatment dose-dependently resulted in lesser seizure severity according to Racine's scale, delayed start-up latency of the first myoclonic jerk and attenuated the spike percentages detected by EEG in seizure-induced rats." | 1.91 | Immunosuppressant Tacrolimus Treatment Delays Acute Seizure Occurrence, Reduces Elevated Oxidative Stress, and Reverses PGF2α Burst in the Brain of PTZ-Treated Rats. ( Egilmez, CB; Erbas, O; Erdogan, MA; Pazarlar, BA, 2023) |
| "Epilepsy is a complex neurological disease characterized by spontaneous recurrent seizures that affect around 1% of the global population." | 1.91 | Comprehensive characterization of amino acids and water-soluble vitamins in a pentylenetetrazole-induced seizures rat model. ( Jiang, X; Liu, J; Wang, Y, 2023) |
| "The administration of TMP reduced the seizure score and percentage of kindled animals dose-dependently." | 1.91 | Tetramethylpyrazine contributes to the neuroprotection in a rodent epileptic model of pentylenetetrazole-induced kindling. ( Danduga, RCSR; Kanakaraju, VK; Kandaswamy, S; Kola, PK; Polopalli, S; Shaik, HB, 2023) |
| "CA6 and CA12 (p." | 1.91 | Anticonvulsant Profile of Selected Medium-Chain Fatty Acids (MCFAs) Co-Administered with Metformin in Mice in Acute and Chronic Treatment. ( Nieoczym, D; Pieróg, M; Samorek-Pieróg, M; Socała, K; Wlaź, P; Wyska, E, 2023) |
| "Epilepsy is a common chronic brain disease." | 1.91 | Kalirin is involved in epileptogenesis by modulating the activity of the Rac1 signaling pathway. ( Chen, L; Cui, W; Huang, H; Luo, T; Xu, Z; Zhu, M, 2023) |
| "Epilepsy is one of the most serious worldwide neurological disorders that lead to the cognitive-psychosocial insults in recurrent seizures." | 1.91 | Ceftriaxone and selenium mitigate seizures and neuronal injury in pentylenetetrazole-kindled rats: Oxidative stress and inflammatory pathway. ( Abdelaziz, EZ; Ali, DA; Kolieb, E; Mohamed, AM, 2023) |
| "Meanwhile, it decreased the seizure severity and reduced seizure-caused anxious behavior in the PTZ-kindling mice, suggesting a significant antiepileptic activity and anxiolytic/anxiogenic potential." | 1.91 | Herb pair of Polygala tenuifolia Willd and Acorus tatarinowii Schott decoction attenuates seizures and alleviates anxiety in mice: Evidence for modulating inflammation, alleviating oxidative stress and mediating GABA pathway. ( He, X; Liu, Y; Xie, Y; Yang, Y; Yuan, X, 2023) |
| "Epilepsy is a chronic brain disorder characterized by unprovoked and recurrent seizures, of which 60% are of unknown etiology." | 1.91 | Seizure-induced increase in microglial cell population in the developing zebrafish brain. ( Ameli, C; Cordero-Maldonado, ML; Crawford, AD; Donato, C; Martins, TG; Mombaerts, L; Peri, F; Skupin, A; Soliman, R, 2023) |
| "Epilepsy is caused by an excessive recurrent excitatory neuronal firing, characterized by motor, psychomotor, and sensory impairments." | 1.91 | Impact of noscapine on halting the progression of pentylenetetrazole induced kindling epilepsy in mice. ( Dhureja, M; Gupta, R; Kumar, P; Soni, D; Upadhayay, S, 2023) |
| "Epilepsy is a prevalent neurological disease, affecting approximately 1-2% of the global population." | 1.91 | Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish. ( Benvenutti, R; Chitolina, R; Herrmann, AP; Linazzi, A; Marcon, M; Piato, A; Reis, CG; Stahlhofer-Buss, T, 2023) |
| "Epilepsy is a chronic neurological disease with recurrent seizures." | 1.91 | Can endoplasmic reticulum stress observed in the PTZ-kindling model seizures be prevented with TUDCA and 4-PBA? ( Akyüz, E; Ateş, Ş; Doğanyiğit, Z; Okan, A; Shaikh, MF; Taheri, S; Yılmaz, S; Yılmaz, Z, 2023) |
| "CCN1 decreasing effectively prolongs seizure incubation period and decreases seizure duration." | 1.91 | Decrease of Cellular Communication Network Factor 1 (CCN1) Attenuates PTZ-Kindled Epilepsy in Mice. ( Huang, S; Liao, Y; Zhang, H; Zhang, Y; Zhao, H, 2023) |
| "Epilepsy is a chronic neurological condition that disrupts the normal functioning of the brain and it is characterized by seizures." | 1.91 | Gut-Brain-axis: effect of basil oil on the gut microbiota and its contribution to the anticonvulsant properties. ( Amidu, SB; Boamah, VE; Ekuadzi, E; Mante, PK, 2023) |
| "The treatment with sinigrin significantly delayed the appearance of the seizure symptoms in comparison to that of the PTZ group." | 1.72 | Preventive Effects of Sinigrin Against the Memory Deterioration in the Pentylenetetrazole-Kindled Male Wistar Rats: Possible Modulation of NLRP3 Pathway. ( Aghaie, F; Hosseini, A; Koneshlou, S; Moradifar, F; Rajabi, M, 2022) |
| "Epilepsy is one of the most common chronic neurological diseases." | 1.72 | Vitamin E Exerts Neuroprotective Effects in Pentylenetetrazole Kindling Epilepsy via Suppression of Ferroptosis. ( Guo, C; Guo, K; Hu, Z; Li, J; Peng, J; Wu, S; Zhang, X; Zhang, Z, 2022) |
| "Epilepsy is a common chronic neurological disorder worldwide, but its entire pathology remains unknown." | 1.72 | Baicalin suppresses neuron autophagy and apoptosis by regulating astrocyte polarization in pentylenetetrazol-induced epileptic rats and PC12 cells. ( Cheng, Y; Guo, W; Jia, Z; Li, G; Lu, Y; Pei, L; Yang, X; Zhang, S, 2022) |
| "Epilepsy is one of the most common serious brain disorders, affecting about 1% of the population all over the world." | 1.72 | Anti-kindling effect of Ginkgo biloba leaf extract and L-carnitine in the pentylenetetrazol model of epilepsy. ( Abd El-Gawad, HS; Abd Elkader, HAE; Alhasani, RH; El-Sayed, SA; Essawy, AE; Tousson, E, 2022) |
| "Epilepsy is a neurological disease that pathologically affects brain functions." | 1.72 | Pentylenetetrazole-induced kindling rat model: miR-182 and miR-27b-3p mediated neuroprotective effect of thymoquinone in the hippocampus. ( Acar, S; Akbas, F; Gorucu Yilmaz, Ş; Meral, I; Okur, SK; Pala Acikgoz, N; Pala, M; Taslidere, E, 2022) |
| "Among models of acutely evoked seizures, whereas anticonvulsive effects of soticlestat were identified in Frings mice, a genetic model of audiogenic seizures, it was found ineffective in MES, acute PTZ seizures, and 6-Hz seizures." | 1.72 | Anticonvulsive properties of soticlestat, a novel cholesterol 24-hydroxylase inhibitor. ( Fujimoto, S; Hasegawa, S; Kondo, S; Metcalf, CS; Miyamoto, M; Nishi, T; Sunahara, E; Watanabe, S; White, HS, 2022) |
| "A coil method was used to detect motor seizures consisting of small amplitude 19-21 Hz muscle contractions." | 1.72 | Detection of pentylenetetrazol-induced seizure activity in the 19-21 Hz beta range using a magnetic coil induction method. ( Chang, WJ; Lu, HC; Shyu, BC; Wei Huang, AC, 2022) |
| " However, the low bioavailability of resveratrol and the difficulty of reaching the targeted location in the brain reduce its efficacy considerably." | 1.72 | Resveratrol-Loaded Glutathione-Coated Collagen Nanoparticles Attenuate Acute Seizures by Inhibiting HMGB1 and TLR-4 in the Hippocampus of Mice. ( Aggarwal, NB; Akhter, J; Arora, I; Asad, M; Hoda, U; Rastogi, S; Samim, M; Siddiqui, MA, 2022) |
| "Evidence suggests that improving brain inflammation can inhibit the epileptogenesis process and help the emergence of new drugs for the treatment of epilepsy." | 1.72 | Thiamine alleviates cognitive impairment and epileptogenesis by relieving brain inflammation in PTZ-induced kindling rat model. ( Akkaya, R; Filiz, AK; Karabulut, S, 2022) |
| "Epileptic seizures are associated with the overproduction of free radicals in the brain leading to neuronal cell death." | 1.72 | The Effects of Vitamin D3 and Melatonin Combination on Pentylenetetrazole- induced Seizures in Mice. ( Dehdashtian, E; Hosseinzadeh, A; Jafari-Sabet, M; Mehrzadi, S, 2022) |
| "Epilepsy was attenuated in AG490 and miR-146a agomir + AG490 groups compared with that in Model group." | 1.72 | miR-146a/KLF4 axis in epileptic mice: A novel regulator of synaptic plasticity involving STAT3 signaling. ( Chen, J; Chen, Y; Li, Y, 2022) |
| "Epilepsy is characterized by the occurrence of seizures, and the high prevalence of epilepsy-associated comorbidities affects the quality of patients' life." | 1.72 | Pentylenetetrazole-induced seizures cause impairment of memory acquisition and consolidation in zebrafish (Danio rerio). ( Bertoncello, KT; Bonan, CD; Zanandrea, R, 2022) |
| "Epilepsy is a common neurological disorder which affects 50 million people worldwide." | 1.72 | Evaluation of Resveratrol and Piceatannol Anticonvulsant Potential in Adult Zebrafish (Danio rerio). ( Aguiar, GPS; Lima-Rezende, CA; Müller, LG; Oliveira, JV; Pedroso, J; Piato, A; Schneider, SE; Siebel, AM, 2022) |
| "Epilepsy is often considered to be a progressive neurological disease, and the nature of this progression remains unclear." | 1.72 | Insights into the development of pentylenetetrazole-induced epileptic seizures from dynamic metabolomic changes. ( Cheng, P; Jia, P; Liao, S; Meng, K; Xiao, C; Xu, R; Zhao, X; Zheng, X, 2022) |
| "Ferulic acid treatment, on the other hand, significantly decreased seizure susceptibility and depression like behavior, possibly because of increased progesterone, restored estradiol, corticosterone, monoamines, and GAD enzyme activity." | 1.72 | Ferulic acid inhibits catamenial epilepsy through modulation of female hormones. ( Dhillon, HK; Goel, RK; Singh, T, 2022) |
| "Epilepsy is a widespread and mainly severe neurological condition portrayed by recurring spontaneous seizures caused by the brain's abnormal electrical activity." | 1.72 | Anti-seizure effect of zinc on PTZ-induced epilepsy in rat model. ( Erbas, O; Erdogan, MA; Kirazlar, M, 2022) |
| "Epilepsy is a neurological disorder caused by abnormally elevated neuronal firing and excitability." | 1.72 | Decreased Spire2 Expression is Involved in Epilepsy. ( Guo, Y; Hao, L; Jing, W; Peng, X; Wang, X; Yang, M; Yang, Y; Zhang, H, 2022) |
| " Using an animal model of chemically-induced epileptic seizures, we tested exercise alone as non-pharmacological therapy, and exercise combined with an anti-inflammatory drug." | 1.72 | Aerobic exercise, alone or combined with an anti-inflammatory drug, reduces the severity of epileptic seizures and levels of central pro-inflammatory cytokines in an animal model of epileptic seizures. ( Barbosa, BB; Coitinho, AS; de Lima Rosa, G; Domingues, AM; Guzzo, EFM; Nunes, SEB; Padilha, RB; Siqueira, IR, 2022) |
| "Their effects on seizure susceptibility and spontaneous epileptic seizures were evaluated with a pentylenetetrazol (PTZ) test in 2 weeks and with continuous video and wireless electroencephalography (EEG) monitoring between 2 and 6 weeks after injury, respectively." | 1.62 | Blocking receptor for advanced glycation end products (RAGE) or toll-like receptor 4 (TLR4) prevents posttraumatic epileptogenesis in mice. ( Chai, Z; Jin, X; Ma, C; Ping, X; Wang, W; White, FA, 2021) |
| "Melatonin has been used in clinical anti-epileptic studies, but its effect on epileptic comorbidities is unknown, and the underlying mechanism needs further investigation." | 1.62 | Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish. ( Gao, D; Jin, M; Li, N; Liu, K; Mou, L; Ren, Q; Sik, A; Zhang, M; Zhang, S, 2021) |
| "In the search for new antiseizure drugs (ASDs) to treat epilepsy, it is yet unclear which types of coumarins are particularly interesting as a systematic analysis has not been reported." | 1.62 | Comparative Antiseizure Analysis of Diverse Natural Coumarin Derivatives in Zebrafish. ( Budzyńska, B; Copmans, D; de Witte, PAM; Jóźwiak, K; Kozioł, E; Skalicka-Woźniak, K, 2021) |
| "Epilepsy is a chronic brain disease affecting millions of people worldwide." | 1.62 | Environmental enrichment alters neurobehavioral development following maternal immune activation in mice offspring with epilepsy. ( Mosaferi, B; Najdi, N; Salari, AA; Zeraati, M, 2021) |
| "In various organisms, stress is a seizure-related comorbidity." | 1.62 | Stress increases susceptibility to pentylenetetrazole-induced seizures in adult zebrafish. ( Canzian, J; Franscescon, F; Müller, TE; Rosa, LV; Rosemberg, DB; Souza, TP; Stefanello, FV, 2021) |
| "Seizures were induced in rats (postnatal day 10) by 5% O2 exposure for 15 min." | 1.62 | FTY720 administration following hypoxia-induced neonatal seizure reverse cognitive impairments and severity of seizures in male and female adult rats: The role of inflammation. ( Farbood, Y; Ghafouri, S; Najafian, SA; Sarkaki, A, 2021) |
| "Pharmaco-resistant Epilepsy has been a major challenge for medical interventions in controlling seizures." | 1.62 | Gene Expression Analysis Identifies Cholesterol Metabolism Dysregulation in Hippocampus of Phenytoin-Resistant Pentylenetetrazol-Kindled Epileptic Mice. ( Amalakanti, S; Bhat, UA; Chakravarty, S; Khandelwal, N; Kumar, A; Mylavarapu, MB; Sundarachary, NV, 2021) |
| "camptopus in acute models of epileptic seizures in Wistar rats." | 1.62 | Anticonvulsant effects of the aqueous and methanol extracts from the stem bark of Psychotria camptopus Verdc. (Rubiacaea) in rats. ( Chouna, R; Dongmo, AK; Fokoua, AR; Kaptué Wuyt, A; Ndjenda, MK; Nguelefack, TB; Nkeng-Efouet, PA; Tatsinkou Bomba, FD, 2021) |
| " Various experimental models have been used to study epilepsy, including that based on acute or chronic administration of Pentylenetetrazol (PTZ)." | 1.62 | Pentylenetetrazol-induced seizures in adult rats are associated with plastic changes to the dendritic spines on hippocampal CA1 pyramidal neurons. ( Flores-Soto, M; González-Burgos, I; Martín-Amaya-Barajas, FL; Orozco-Suárez, S; Romero-Guerrero, C; Tejeda-Martínez, A; Vázquez-Hernández, N, 2021) |
| "Pediatric patients with epilepsy are prone to cognitive impairments during growth and long-term use of most antiepileptic drugs (AED)." | 1.62 | Pharmacological Activity of Pyrazole Derivatives as an Anticonvulsant for Benefit against Epilepsy. ( Gao, M; Qu, K; Wang, X; Zhang, W, 2021) |
| "Carbamazepine (CBZ) is an anticonvulsant drug that usually is used for the treatment of seizures." | 1.62 | Exercise Improved the Anti-Epileptic Effect of Carbamazepine through GABA Enhancement in Epileptic Rats. ( Barzroodi Pour, M; Bayat, M; Karimzadeh, F; Navazesh, A; Soleimani, M, 2021) |
| "Therefore, we hypothesized that seizure detection is possible through vagus nerve electroneurogram (VENG) recording." | 1.62 | Vagus Nerve Electroneurogram-Based Detection of Acute Pentylenetetrazol Induced Seizures in Rats. ( Cury, J; Delbeke, J; Doguet, P; El Tahry, R; Nonclercq, A; Smets, H; Stumpp, L; Vespa, S, 2021) |
| "Epilepsy is a chronic encephalopathy and one of the most common neurological disorders." | 1.62 | Inhibition of Death-associated Protein Kinase 1 protects against Epileptic Seizures in mice. ( Chen, D; Gan, CL; Hu, L; Lan, G; Lee, TH; Liu, H; Mei, Y; Shui, X; Wang, L; Xia, Y; Zhang, T; Zou, Y, 2021) |
| "Epilepsy is a neurodegenerative brain disorder characterized by recurrent seizure attacks." | 1.62 | Carveol Attenuates Seizure Severity and Neuroinflammation in Pentylenetetrazole-Kindled Epileptic Rats by Regulating the ( Al Kury, LT; Alattar, A; Alshaman, R; Alvi, AM; Feng, J; Khan, AU; Li, S; Muhammad, AJ; Shah, FA; Ullah, I, 2021) |
| "The present study aims to evaluate the efficacy of selenium (Se) alone or combined with carbamazepine (CBZ) against the adverse effects induced by the chemoconvulsant pentylenetetrazole (PTZ) in the cortex of adult male rats." | 1.56 | Electrophysiological and Neurochemical Assessment of Selenium Alone or Combined with Carbamazepine in an Animal Model of Epilepsy. ( Aboul Ezz, HS; Ali, MA; Mohammed, HS; Zedan, A, 2020) |
| "Increased behavioral manifestations and seizure severity was observed in the stress group compared with the control group at both ages." | 1.56 | Physical exercise during pregnancy minimizes PTZ-induced behavioral manifestations in prenatally stressed offspring. ( Arida, RM; da Silva, EA; Gutierre, RC; Lopim, GM, 2020) |
| "In India, it is used for the treatment of epilepsy as traditional medicine." | 1.56 | An interaction study of Ocimum sanctum L. and levetiracetam in pentylenetetrazole kindling model of epilepsy. ( Dinda, AK; Kaleekal, T; Katyal, J; Pattnaik, SS; Sarangi, SC, 2020) |
| " The employment of different dosage groups enabled us to characterize the dose range reliably inducing seizures." | 1.56 | Pentylenetetrazole-induced Seizure Susceptibility in the Tau58/4 Transgenic Mouse Model of Tauopathy. ( De Deyn, PP; Valkenburg, F; Van Dam, D; Van Erum, J, 2020) |
| "Epilepsy is a debilitating neurological illness that affects all aspect of an individual life." | 1.56 | Prolonged febrile seizure history exacerbates seizure severity in a pentylenetetrazole rat model of epilepsy. ( Alese, OO; Mabandla, MV; Mkhize, NV; Rakgantsho, C; Zulu, S, 2020) |
| "Piperine is a chief alkaloid compound of natural black pepper exhibits excellent anti-convulsant efficiency in the anti-epileptic treatment." | 1.56 | Rational design of ultra-small photoluminescent copper nano-dots loaded PLGA micro-vessels for targeted co-delivery of natural piperine molecules for the treatment for epilepsy. ( Ding, SW; Nie, XD; Yang, L; Zhang, DT; Zhang, WG; Zhu, D, 2020) |
| "Valproic acid (VPA) is a widely used antiepileptic drugs." | 1.56 | Autophagy associated with the efficacy of valproic acid in PTZ-induced epileptic rats. ( Hu, L; Li, Q; Li, X; Li, Y; Li, Z; Lu, J; Tao, J; Wang, G; Wang, Y, 2020) |
| "Epilepsy is one of the most common neurological diseases." | 1.56 | COX-2-PGE ( Dong, J; Gan, G; Hu, S; Li, X; Yang, J; Yao, Y; Zhang, A; Zhang, C; Zhengxie, J; Zhu, X, 2020) |
| "Ibuprofen (IBP) is a well-known anti-inflammatory agent that reduces the neuroinflammatory response and neuronal damage." | 1.56 | Ibuprofen Exerts Antiepileptic and Neuroprotective Effects in the Rat Model of Pentylenetetrazol-Induced Epilepsy via the COX-2/NLRP3/IL-18 Pathway. ( Guo, C; Guo, K; Hu, Z; Li, J; Liu, R; Peng, J; Wu, S; Zhang, X, 2020) |
| "New mouse models of epilepsy are needed to better understand the complex genetic architecture of seizures and to identify therapeutics." | 1.56 | Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility. ( Bell, TA; Dalton, KA; Gu, B; Hock, P; Miller, DR; Pan, Y; Pardo-Manuel de Villena, F; Philpot, BD; Shaw, GD; Shorter, JR; Williams, LH, 2020) |
| "Epilepsy is a chronic disease, while epileptogenesis is a latent period where brain will be transformed into an epileptic one." | 1.56 | Integrative analysis of non-targeted lipidomic data and brain structural imaging identifies phosphatidylethanolamine associated with epileptogenesis. ( Chen, L; Gong, M; Kinoshita, M; Lai, W; Li, W; Peng, A; Qiu, X; Yang, L; Zhang, L; Zheng, W, 2020) |
| "Paeonol can also increase the activities of total antioxidant capacity, SOD and catalase activity and reduce MDA content as well." | 1.51 | Anticonvulsant and Neuroprotective Effects of Paeonol in Epileptic Rats. ( Agbo, E; Liu, DH; Zhang, SH; Zhu, JL, 2019) |
| "Epilepsy is a chronic neurological disease." | 1.51 | Effect of Ibuprofen on Autophagy of Astrocytes During Pentylenetetrazol-Induced Epilepsy and its Significance: An Experimental Study. ( Guo, C; Guo, K; Hu, Z; Li, J; Liu, R; Peng, J; Wu, S; Zhang, W, 2019) |
| "The animals were assessed for seizure score, neuronal damage and inflammatory cytokines levels (IL-1β, IL-6 and TNF-α) in hippocampus." | 1.51 | Effect of dimethyl fumarate on neuroinflammation and apoptosis in pentylenetetrazol kindling model in rats. ( Banerjee, D; Bhatia, A; Chakrabarti, A; Kumari, P; Saha, L; Singh, J; Singh, N, 2019) |
| "Epilepsy is a common clinical syndrome characterized by sudden and recurrent attacks and temporary central nervous system dysfunction caused by excessive discharge of neurons in the brain." | 1.51 | Exploratory Cortex Metabolic Profiling Revealed the Sedative Effect of Amber in Pentylenetetrazole-Induced Epilepsy-Like Mice. ( Chen, C; Duan, J; Guo, J; Guo, S; Qian, D; Shang, E; Tang, Z; Yan, H; Zhao, M; Zhu, Y; Zhu, Z, 2019) |
| "Epilepsy is a neurological disorder of the central nervous system characterized by hypersynchronized neuronal activity and has been associated with oxidative stress." | 1.51 | Expression of nuclear factor-erythroid 2-related factor 2 in rat brain following the administration of kainic acid and pentylenetetrazole. ( Díaz-Ruíz, A; Flores-Espinosa, P; Manjarrez, J; Méndez-Armenta, M; Nava-Ruíz, C; Ruíz-Díaz, A; Yescas-Gómez, P; Zaga-Clavellina, V, 2019) |
| "Epilepsy is a group of neurological disorders characterized by recurrent seizures that disturbs about 60 million people worldwide." | 1.51 | Excavating precursors from the traditional Chinese herb Polygala tenuifolia and Gastrodia elata: Synthesis, anticonvulsant activity evaluation of 3,4,5-trimethoxycinnamic acid (TMCA) ester derivatives. ( Bai, Y; Chen, X; He, X; Sun, Y; Wu, S; Xie, J; Zhang, Y; Zhao, Z; Zheng, X, 2019) |
| "Epilepsy is a complicated neurological disorder that occurs worldwide and features several kinds of comorbidities in addition to recurrent seizures." | 1.48 | Adenosine A1 Receptors Play an Important Protective Role Against Cognitive Impairment and Long-Term Potentiation Inhibition in a Pentylenetetrazol Mouse Model of Epilepsy. ( Guo, Y; Hu, Q; Kang, H; Lian, L; Liu, X; Xu, F; Zhang, N; Zhou, Q; Zhu, S, 2018) |
| "KD alleviated seizure severity, decreased the number of Fluoro-jade B (FJB)-positive cells in the hippocampus of kindled rats." | 1.48 | Ketogenic diet attenuates neuronal injury via autophagy and mitochondrial pathways in pentylenetetrazol-kindled seizures. ( Hou, Q; Jia, MM; Jiang, Y; Lu, YQ; Qiu, T; Wang, BH; Wang, XH; Zhang, ZX, 2018) |
| "Ginsenoside Rb1 (Rb1) has been reported to have varieties of neuroprotective effects." | 1.48 | Ginsenoside Rb1 Protects the Brain from Damage Induced by Epileptic Seizure via Nrf2/ARE Signaling. ( Miao, W; Shi, Y; Teng, J; Zhang, L, 2018) |
| "Epilepsy is one of the furthermost common neurodegenerative diseases affecting above 50 million individuals worldwide." | 1.48 | Neuroprotective mechanisms of sildenafil and selenium in PTZ-kindling model: Implications in epilepsy. ( El-Azab, MF; Moustafa, YM; Tawfik, KM, 2018) |
| "Epilepsy is a chronic neurological disorder which affects 65 million worldwide population and characterized by recurrent seizure in epileptic patients." | 1.48 | The anti-epileptogenic and cognition enhancing effect of novel 1-[4-(4-benzo [1, 3] dioxol-5-ylmethyl-piperazin-1-yl)-phenyl]-3-phenyl-urea (BPPU) in pentylenetetrazole induced chronic rat model of epilepsy. ( Kumari, S; Mishra, CB; Siraj, F; Tiwari, AK; Tiwari, M; Yadav, R, 2018) |
| "Thereafter, the PTZ seizure threshold was measured in control and HFD rats." | 1.48 | The effect of high-fat diet on seizure threshold in rats: Role of oxidative stress. ( Al Yacoub, ON; Alrabadi, N; Alzoubi, KH; Azab, MA; Banihani, SA; Hasan, ZA; Khabour, OF; Mayyas, FA, 2018) |
| "BACKGROUND Epilepsy is a complex neurologic disorder with abnormal electrical impulses in the brain." | 1.48 | Modulation of P2X Purinoceptor 3 (P2X3) in Pentylenetetrazole-Induced Kindling Epilepsy in Rats. ( Han, Z; Wang, H; Xia, J; Zhang, Q, 2018) |
| "Seizures are sustained neuronal hyperexcitability in brain that result in loss of consciousness and injury." | 1.48 | Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish. ( Han, L; He, Q; Ji, X; Jin, M; Liu, K; Sheng, W, 2018) |
| "In six-hertz-seizure test the MeCO (25, 50, 100 and 200mg/kg) and AeCO (50, 100, 200, 400 and 800mg/kg) showed significant protection compared to control group, and MeCO was more potent than AeCO." | 1.46 | Ameliorative potential of Colebrookea oppositifolia methanolic root extract against experimental models of epilepsy: Possible role of GABA mediated mechanism. ( Prasad, NBL; Venkataranganna, MV; Viswanatha, GL, 2017) |
| "Epilepsy is one of the most common neurological disorders and the administration of antiepileptic drugs (AEDs) is the most common treatment." | 1.46 | DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy. ( Li, XM; Ma, XX; Ni, KM; Sun, P; Wei, X; Xu, M; Yang, CH; Yang, CR; Zhang, Y; Zhang, YJ, 2017) |
| "Recurrent seizures that define epilepsy are often accompanied by psychosocial problems and cognitive deficits with incompletely understood aetiology." | 1.46 | The PTZ kindling mouse model of epilepsy exhibits exploratory drive deficits and aberrant activity amongst VTA dopamine neurons in both familiar and novel space. ( Ahmadi, M; Dufour, JP; Mirnajafi-Zadeh, J; Saab, BJ; Seifritz, E, 2017) |
| "Epilepsy is a chronic neurological condition, with over 30% of cases unresponsive to treatment." | 1.46 | Automated analysis of brain activity for seizure detection in zebrafish models of epilepsy. ( Copmans, D; de Witte, PAM; Hunyadi, B; Siekierska, A; Sourbron, J, 2017) |
| "Epilepsy is fourth most common neurological disorders associated with depression and cognitive deficits." | 1.46 | Agmatine for combined treatment of epilepsy, depression and cognitive impairment in chronic epileptic animals. ( Bagga, N; Gawande, DY; Goel, RK; Kaur, A; Kaur, N; Singh, T, 2017) |
| "for 15 days." | 1.46 | Ferulic Acid Supplementation for Management of Depression in Epilepsy. ( Goel, RK; Kaur, T; Singh, T, 2017) |
| "Epilepsy is one of the most common neurologic disorders worldwide with no distinguishable cause in 60% of patients." | 1.46 | Toxoplasmosis accelerates acquisition of epilepsy in rats undergoing chemical kindling. ( Asgari, T; Babaie, J; Choopani, S; Gharagozli, K; Golkar, M; Sayyah, M, 2017) |
| "The onset and duration of seizure were recorded." | 1.46 | Intranasal nerve growth factor attenuating the seizure onset via p75R/Caspase pathway in the experimental epilepsy. ( Duan, Y; Feng, F; Lei, J; Lian, L; Liang, Q; Liu, Z; Wang, F; Xu, F; Zhang, N, 2017) |
| " Serum levels of valproate were estimated using HPLC for pharmacokinetic study." | 1.46 | Pharmacokinetic and pharmacodynamic interaction of hydroalcoholic extract of Ocimum sanctum with valproate. ( Gupta, YK; Joshi, D; Kaleekal, T; Kumar, R; Sarangi, SC, 2017) |
| "Lamotrigine (LTG) is a broad-spectrum antiepileptic drug that is widely used in clinic." | 1.46 | Effect of lamotrigine on epilepsy-induced cognitive impairment and hippocampal neuronal apoptosis in pentylenetetrazole-kindled animal model. ( Dong, RF; Tian, S; Wang, WP; Zhang, B; Zhang, C; Zhang, JW, 2017) |
| "Epilepsy is a common brain disorder characterized by the occurrence of recurring, unprovoked seizures." | 1.46 | EGAR, A Food Protein-Derived Tetrapeptide, Reduces Seizure Activity in Pentylenetetrazole-Induced Epilepsy Models Through α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionate Receptors. ( Cai, M; Cai, S; Chen, L; Duan, S; Gu, H; Lin, R; Ling, C; Lu, J; Pan, X; Wang, Y; Zhu, H, 2017) |
| "Linalool is a major constituent of the essential oil of several plant species and possesses several biological activities." | 1.46 | The effects of linalool on the excitability of central neurons of snail Caucasotachea atrolabiata. ( Bazleh, S; Janahmadi, M; Vatanparast, J, 2017) |
| "Depression was evaluated in all experimental groups using the tail suspension and sucrose preference test on days 1, 5, 10 and 15, 2 h after pentylenetetrazole challenge." | 1.46 | Adjuvant quercetin therapy for combined treatment of epilepsy and comorbid depression. ( Goel, RK; Kaur, T; Singh, T, 2017) |
| "In spite of recent advances in the treatment of epilepsy, up to 35% of people living with the condition do not respond to accessible anti-epileptic drugs (AEDs) and continue to experience regular, devastating and potentially life-threatening seizures." | 1.46 | Apelin-13 protects rat primary cortical glia-neuron co-culture against pentylenetetrazole-induced toxicity. ( Asadi-Shekaari M, M; Esmaeili-Mahani, S; Kalantaripour, TP; Najafipour, H; Sheibani, V, 2017) |
| "Pretreatment with spermine, considerably, reversed the PTZ induced alterations." | 1.46 | Protective effect of spermine against pentylenetetrazole kindling epilepsy induced comorbidities in mice. ( Kumar, M; Kumar, P, 2017) |
| "Understanding how the brain responds to seizures is important for development of new treatment strategies for epilepsy, a neurological condition characterized by recurrent and unprovoked seizures." | 1.46 | Cellular responses to recurrent pentylenetetrazole-induced seizures in the adult zebrafish brain. ( Beattie, CE; Berberoglu, MA; Duy, PQ; Hall, CW, 2017) |
| "Epilepsy is a kind of neurogenic diseases with high prevalence and characterized by seizure, brain paradoxical discharge and convulsion in spontaneous, transient, recurrent and uncontrolled manner." | 1.43 | [Establish and use of an epilepsy model in larval zebrafish]. ( Song, DQ; Tang, S; Zhang, JP; Zheng, YM, 2016) |
| "Traumatic brain injury was exerted to parieto-temporal cortex of anaesthetised rats by controlled cortical impact (CCI, 5 mm round tip, 4." | 1.43 | Traumatic brain injury accelerates kindling epileptogenesis in rats. ( Amiri, Z; Choopani, S; Eslami, M; Etemadi, F; Ghanbari, E; Hadjighassem, M; Sayyah, M; Soleimani, M, 2016) |
| "Epilepsy or seizure disorder is among the least understood chronic medical conditions affecting over 65 million people worldwide." | 1.43 | Disruption of polycystin-L causes hippocampal and thalamocortical hyperexcitability. ( Basora, N; Contreras, D; Du, Y; Harvey, M; Luo, C; Schreiber, TH; Su, X; Wu, M; Yao, G; Zhou, J, 2016) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 1.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "Pre-treatment with liraglutide (75 and 150 μg/kg) significantly prevented the seizure severity, restored behavioural activity, oxidative defence enzymes, and altered level of neurochemicals in mice brain." | 1.43 | Neurochemical modulation involved in the beneficial effect of liraglutide, GLP-1 agonist on PTZ kindling epilepsy-induced comorbidities in mice. ( Koshal, P; Kumar, P, 2016) |
| "Seizures were induced in rats by daily injection of PTZ for 36 days." | 1.43 | Luteolin rescues pentylenetetrazole-induced cognitive impairment in epileptic rats by reducing oxidative stress and activating PKA/CREB/BDNF signaling. ( Chang, YN; Fu, T; Liu, JQ; Qu, ZZ; Wang, WP; Zhen, JL, 2016) |
| "Epilepsy is a common neurological disease characterized by periodic seizures." | 1.43 | Prediction of seizure incidence probability in PTZ model of kindling through spatial learning ability in male and female rats. ( Aghaei, Z; Haeri, NA; Palizvan, MR; Rafiei, M; Sadegh, M, 2016) |
| "Seizures were detected in real time from cortical local field potentials, after which DCS was applied." | 1.43 | A Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical Stimulation. ( Guggenmos, D; Lebedev, M; Moreira, D; Nicolelis, MAL; Pais-Vieira, M; Santos, A; Yadav, AP, 2016) |
| "BACKGROUND Epilepsy is the most predominant neurological disorder characterized by recurrent seizures." | 1.43 | Garcinol Upregulates GABAA and GAD65 Expression, Modulates BDNF-TrkB Pathway to Reduce Seizures in Pentylenetetrazole (PTZ)-Induced Epilepsy. ( Hao, F; Jia, LH; Li, XW; Liu, XW; Zhang, YR, 2016) |
| "Epilepsy is a serious brain disorder with diverse seizure types and epileptic syndromes." | 1.43 | AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets. ( Chen, W; Gao, J; Li, XH; Li, YS; Lin, XY, 2016) |
| "Modafinil, is a wake-promoting drug approved by Food and Drugs Administration (FDA) for narcolepsy and sleep-apnoe syndrome." | 1.42 | Effects of modafinil on pentylenetetrazol-induced convulsive epilepsy. ( Aydin, D; Ekici, F; Ozsoy, S, 2015) |
| "Sulforaphane was anticonvulsant in two acute mouse models of epilepsy and protected mice against pilocarpine-induced status epilepticus (SE)." | 1.42 | Sulforaphane is anticonvulsant and improves mitochondrial function. ( Borges, K; Carrasco-Pozo, C; Tan, KN, 2015) |
| " A chronic administration of curcumin (200 mg/kg) was most effective for decreasing the mean frequency of epileptiform discharge." | 1.42 | The involvement of neuronal nitric oxide synthase in the anti-epileptic action of curcumin on pentylenetetrazol-kindled rats. ( Jiang, C; Liu, J; Su, J; Zhu, W, 2015) |
| "Epilepsy is a debilitating disease affecting 1-2% of the world's population." | 1.40 | Novel Vitamin K analogs suppress seizures in zebrafish and mouse models of epilepsy. ( Bestman, JE; Chan, SS; Chou, CJ; Inks, ES; Josey, BJ; Rahn, JJ; Rogers, CE; Stackley, KD, 2014) |
| "Although epilepsy is a common neurological disorder, its mechanism(s) are still not completely understood." | 1.40 | Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models. ( Chen, L; Chen, Y; Jiang, G; Li, J; Li, Z; Wang, X; Wang, Z, 2014) |
| "Muscimol was administered in doses from 0." | 1.40 | Anticonvulsant and behavioral effects of muscimol in immature rats. ( Mareš, P; Mikulecká, A; Tichá, K, 2014) |
| "Perinatal stroke is a common cerebrovascular disorder affecting 1 in every 4000 births; typically associated with epilepsy." | 1.39 | Increased susceptibility to pentetrazol-induced seizures in developing rats after cortical photothrombotic ischemic stroke at P7. ( Brima, T; Mareš, P; Otáhal, J, 2013) |
| "Therefore, we tried to use GA to treat PTZ-induced epilepsy rats." | 1.39 | Glatiramer acetate, an anti-demyelination drug, reduced rats' epileptic seizures induced by pentylenetetrazol via protection of myelin sheath. ( Bai, H; Liu, Z; Meng, F; Xu, R; You, Y; Zhang, H; Zhao, Y, 2013) |
| "Epilepsy is one of the most common neurological disorders, characterized by recurrent seizures, which may increase the content of reactive oxygen and nitrogen species." | 1.39 | Effects of single-dose neuropeptide Y on levels of hippocampal BDNF, MDA, GSH, and NO in a rat model of pentylenetetrazole-induced epileptic seizure. ( Kir, HM; Kuskay, S; Musul, M; Oztaş, B; Sahin, D, 2013) |
| " The mean dosage to induce seizure in the exposed and control group was 54." | 1.39 | Effects of extremely low frequency electromagnetic field (50 Hz) on pentylenetetrazol-induced seizures in mice. ( Fadakar, K; Farzampour, S; Saba, V, 2013) |
| "We examined the seizure susceptibility of these mice to determine if the presence (BXD29-Trl4(lps-2J)/J) or absence (C57BL/10J) of p-ACC, in strains with MCD, confers a differential response to chemi-convulsive treatment." | 1.39 | Differential seizure response in two models of cortical heterotopia. ( Gabel, LA; Ibanez, N; Manglani, M; Ramos, RL; Roberts, J; Rosen, GD, 2013) |
| "Recurrent generalized seizures were caused by repetitive injection of pentylenetetrazol (PTZ) for a period of 4 weeks every other day." | 1.39 | Behavioural and histopathological assessment of the effects of periodic fasting on pentylenetetrazol-induced seizures in rats. ( Coulon, P; Gharakhani, M; Gorji, A; Jafarian, M; Karimzadeh, F; Kazemi, H; Khallaghi, B; Kolivand, PH; Mohamadzadeh, E; Razeghi Jahromi, S, 2013) |
| "Epilepsy is a complex neurological disorder characterized by unprovoked seizures." | 1.39 | Mechanisms of prickle1a function in zebrafish epilepsy and retinal neurogenesis. ( Bassuk, AG; Mei, X; Slusarski, DC; Wu, S, 2013) |
| "Pretreatment with diazepam (DZP) significantly attenuated seizure severity." | 1.39 | Seizures induced by pentylenetetrazole in the adult zebrafish: a detailed behavioral characterization. ( Baggio, S; Battastini, AM; Calcagnotto, ME; Campos, MM; de Oliveira, DL; Dias, RD; Leite, CE; Moro, L; Mussulini, BH; Rico, EP; Rosemberg, DB; Souza, TM; Zenki, KC, 2013) |
| "Capparis ovata (C." | 1.39 | Capparis ovata modulates brain oxidative toxicity and epileptic seizures in pentylentetrazol-induced epileptic rats. ( Akay, MB; Balcı, E; Çelik, Ö; Nazıroğlu, M; Yıldırım, Mİ; Yürekli, VA, 2013) |
| "Valproic acid (VPA) is a major antiepileptic drug (AED) that is less potent than other AEDs." | 1.38 | Synthesis and anticonvulsant evaluation of dimethylethanolamine analogues of valproic acid and its tetramethylcyclopropyl analogue. ( Bialer, M; Shekh-Ahmad, T; Yavin, E, 2012) |
| "(Passifloraceae) has been used for the treatment of epilepsy in several traditional systems of medicine." | 1.38 | Dual protective effect of Passiflora incarnata in epilepsy and associated post-ictal depression. ( Goel, RK; Singh, B; Singh, D, 2012) |
| "Epilepsy is a chronic neurological disorder and well documented to induce cognitive impairment." | 1.38 | Age dependent learning and memory deficit in Pentylenetetrazol kindled mice. ( Goel, RK; Mishra, A, 2012) |
| "Seizures were induced 30 min later using a chemoconvulsant (pentylenetetrazol, PTZ) model, which has been widely used to determine anticonvulsant efficacy of many other antiepileptic drugs in neonatal animals." | 1.38 | Anticonvulsant effect of retigabine during postnatal development in rats. ( Forcelli, PA; Gale, K; Kondratyev, A; Lakhkar, A; Soper, C, 2012) |
| "At the spontaneous recurrent seizure period, acute stress stimulations such as cat's urine and foot electrical shock were applied to observe the behavioral changes and seizure occurrence." | 1.38 | [Effect of acute stress stimulation on the seizure induction in epileptic model rats]. ( Ju, JG; Li, ST; Li, XR; Lu, QC; Sun, Z; Wu, SJ; Zhou, P, 2012) |
| "Epilepsy is a chronic neurological disorder characterized by spontaneous recurrent seizures, which also occur in demyelinating diseases of the central nervous system (CNS) with a higher prevalence." | 1.37 | Myelin damage of hippocampus and cerebral cortex in rat pentylenetetrazol model. ( Bai, H; Chen, LW; Gao, GD; Liu, B; Wang, C; You, Y; Zhang, H, 2011) |
| "Epilepsy is one of the most common neurologic problems worldwide." | 1.37 | Does ghrelin level change after epileptic seizure in rats? ( Ataie, Z; Babri, Sh; Ebrahimi, H; Golzar, MG; Mohaddes, G, 2011) |
| "Pretreatment of trimetazidine in all doses showed an ameliorating effect on biochemical alteration induced by PTZ treatment." | 1.37 | Anticonvulsant and antioxidant actions of trimetazidine in pentylenetetrazole-induced kindling model in mice. ( Bharal, N; Jain, S; Khurana, S; Mediratta, PK; Sharma, KK, 2011) |
| "Epilepsy is a common neurological disorder, which is attributed to uncontrollable abnormal hyper-excitability of neurons." | 1.37 | Focused ultrasound-mediated suppression of chemically-induced acute epileptic EEG activity. ( Bystritsky, A; Chung, YA; Fischer, K; Jolesz, FA; Jung, KI; Maeng, LS; Min, BK; Park, SI; Yoo, SS; Zhang, Y, 2011) |
| "Topiramate (TOP) is a novel drug with broad antiepileptic effect, and its effect on brain cortex MMCA is not known." | 1.37 | Topiramate modulates hippocampus NMDA receptors via brain Ca(2+) homeostasis in pentylentetrazol-induced epilepsy of rats. ( Kutluhan, S; Naziroğlu, M; Vural, H; Yilmaz, M; Yilmaz, N; Yürekli, VA, 2011) |
| "The closed-loop seizure controller was applied to three Long-Evans rats with spontaneous spike-wave discharges (non-convulsive) and three Long-Evans rats with epileptiform activities induced by pentylenetetrazol (PTZ) injection (convulsive) for evaluation." | 1.37 | Closed-loop seizure control on epileptic rat models. ( Chang, DW; Chiueh, H; Liang, SF; Liao, YC; Shaw, FZ; Young, CP, 2011) |
| "Epilepsy is suppressed by reducing the temperature to reduce the duration of this epileptic episode." | 1.37 | Wireless and batteryless biomedical microsystem for neural recording and epilepsy suppression based on brain focal cooling. ( Chang, CW; Chiou, JC; Hou, KC; Huang, YH; Shaw, FZ, 2011) |
| " Piperine (20 mg/kg orally) was administered along with curcumin to enhance the bioavailability of the latter up to 20-fold more." | 1.36 | Antioxidant potential of curcumin against oxidative insult induced by pentylenetetrazol in epileptic rats. ( Jyothy, A; Munshi, A; Nehru, B; Sharma, V, 2010) |
| " The results of this long-term study suggest that HUMSCs transplantation, 1 of the most potential treatments for Parkinson's disease, is an effective and safe approach." | 1.36 | Long-term efficacy and safety of human umbilical cord mesenchymal stromal cells in rotenone-induced hemiparkinsonian rats. ( Cao, X; Chen, C; Huang, J; Jia, M; Liang, Z; Lin, Z; Sun, S; Wang, T; Xiong, J; Xiong, N; Zhang, Z, 2010) |
| " Comparative pharmacokinetic analysis showed that α-Cl-TMCD is less susceptible to liver first-pass effect than α-F-TMCD because of lower total (metabolic) clearance and liver extraction ratio." | 1.36 | Comparative pharmacodynamic and pharmacokinetic analysis of two anticonvulsant halo derivatives of 2,2,3,3-tetramethylcyclopropanecarboxamide, an amide of a cyclic analog of valproic acid. ( Bialer, M; Finnell, RH; Hen, N; Kaufmann, D; Pessah, N; Wlodarczyk, B; Yagen, B, 2010) |
| "Pretreatment with celecoxib (2." | 1.36 | Anticonvulsant effect of celecoxib on pentylenetetrazole-induced convulsion: Modulation by NO pathway. ( Dehpour, AR; Hajimirzabeigi, A; Khalilzadeh, O; Maleki, F; Zandieh, A; Zandieh, B, 2010) |
| "Single seizure and epilepsy is one of the most commonly encountered neurologic disorders in elderly individuals, arising as a result of complex and often multiple acquired underlying pathologies." | 1.35 | Effects of progesterone on total brain tissue adenosine deaminase activity in experimental epilepsy. ( Alptekin, M; Erkutlu, I; Kurtul, N; Pençe, S; Tan, U, 2009) |
| "Pentylenetetrazole (PTZ) is a convulsant used to model epileptic seizures in rats." | 1.35 | Pentylenetetrazole-induced seizures affect binding site densities for GABA, glutamate and adenosine receptors in the rat brain. ( Bidmon, HJ; Cremer, CM; Palomero-Gallagher, N; Schleicher, A; Speckmann, EJ; Zilles, K, 2009) |
| "To characterize the interaction between tiagabine (TGB) and valproate (VPA)--two antiepileptic drugs in the mouse pentylenetetrazole (PTZ)-induced clonic seizure model, type I isobolographic analysis for non-parallel dose-response relationship curves (DRRCs) was used." | 1.35 | Interaction of tiagabine with valproate in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves. ( Krzyzanowski, M; Luszczki, JJ; Swiader, MJ, 2009) |
| "The intensities of seizures induced by pentylenetetrazol or pilocarpine, as well as the percentages of convulsing mice, were significantly reduced in A(2A) receptor knockout (A(2A)R KO) animals." | 1.35 | Adenosine A2A receptor deficient mice are partially resistant to limbic seizures. ( Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM, 2009) |
| "Epilepsy is a prominent sign of neurological dysfunction in children with various fetal and maternal deficiencies." | 1.35 | Maternal epileptic seizure induced by pentylenetetrazol: apoptotic neurodegeneration and decreased GABAB1 receptor expression in prenatal rat brain. ( Kim, MO; Naseer, MI; Shupeng, L, 2009) |
| "To investigate the effect of intranasal administration of low dosage recombinant human erythropoietin (r-HuEPO) on seizure in rats." | 1.35 | [Intranasal administration of low dosage recombinant human erythropoietin inhibits seizure in rats]. ( Chen, Z; Hu, WW; Li, XY; Lu, Y; Xu, ZH; Zhang, ZM; Zhao, HW, 2009) |
| "Epilepsy is a common (50 million patients worldwide) neurological disorder characterized by seizures that are caused by episodic abnormal electrical activity in the brain." | 1.35 | Acute seizure tests in epilepsy research: electroshock- and chemical-induced convulsions in the mouse. ( Gasior, M; Giardina, WJ, 2009) |
| "Kindled seizures are widely used to model epileptogenesis, but the molecular mechanisms underlying the attainment of kindling status are largely unknown." | 1.34 | Modified variant of the Rieske iron-sulfur protein in the hippocampus of kindled rats and human epileptic patients. ( Dunoiu, C; Ioana, M; Mogoantă, L; Petcu, EB; Pirici, D; Popa-Wagner, A, 2007) |
| " In addition, modafinil at 180 mg/kg exerted an antiepileptic effect in the MES model; however, at the same dosage it increased the seizure stage in the PTZ-kindling model." | 1.34 | Modafinil exerts a dose-dependent antiepileptic effect mediated by adrenergic alpha1 and histaminergic H1 receptors in mice. ( Chen, CR; Huang, ZL; Qiu, MH; Qu, WM; Urade, Y; Xu, XH; Yao, MH, 2007) |
| "infusion of PTZ; (2) suppress the seizures (clonic and tonic) and lethality induced by i." | 1.33 | Anti-epileptogenic effect of beta-carotene and vitamin A in pentylenetetrazole-kindling model of epilepsy in mice. ( Narenjkar, J; Sayyah, M; Yousefi-Pour, M, 2005) |
| "In PTZ-induced epileptic seizures, the i." | 1.33 | Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. ( Hosseinzadeh, H; Mansouri, MT; Nassiri-Asl, M; Parvardeh, S, 2005) |
| "Both extracts can prevent convulsions as well as convulsion-related GABAergic neuron damage in the brain in the prolonged PTZ kindling model." | 1.33 | Study of antiepileptic effect of extracts from Acorus tatarinowii Schott. ( Chen, L; Gao, MM; Liao, WP; Su, T; Sun, WW; Yang, SQ; Yi, YH, 2005) |
| " No tolerance was evident in the intravenous pentylenetetrazol test after twice-daily dosing of ABT-769 (0." | 1.33 | Preclinical profiling and safety studies of ABT-769: a compound with potential for broad-spectrum antiepileptic activity. ( Bennani, Y; Bitner, RS; Chemburkar, SR; Chen, J; Curzon, P; Dart, MJ; Decker, MW; Durmuller, N; Fox, GB; Giardina, WJ; Grayson, GK; Harris, RR; Hui, JY; Jolly, R; Komater, VA; Ku, Y; Lockwood, M; Marsh, KC; Miner, HM; Nikkel, AL; Pan, JB; Pu, YM; Radek, RJ; Roux, S; Sullivan, JP; Wang, L; Waring, JF, 2005) |
| "We suggest that the seizure-induced decrease of sialidasic activity may not modify the number of sialic acid molecules bound to gangliosides in cell membranes, as compared to areas of increased activity, that may decrease them." | 1.32 | Neuraminidase activity in different regions of the seizing epileptic and non-epileptic brain. ( Ayala, J; Boyzo, A; Gutiérrez, R; Hernández-R, J, 2003) |
| "With pentylenetetrazol (PTZ) induced seizures pre-treated by CBZ, or SR-3, both CBZ and SR-3 were equally effective in providing seizure control and both were superior to the saline control." | 1.32 | Anticonvulsant efficiency, behavioral performance and cortisol levels: a comparison of carbamazepine (CBZ) and a fatty acid compound (SR-3). ( Mostofsky, DI; Rabinovitz, S; Yehuda, S, 2004) |
| " Marked differences in drug sensitivity were observed between models based on single and chronic administration of PTZ showing that the two sets of models are fundamentally different." | 1.32 | Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice. ( Hansen, SL; Sánchez, C; Sperling, BB, 2004) |
| "In the second experiment, seizures were elicited in experimentally naive mice using 50mg/kg of PTZ once daily for 7 days." | 1.32 | MAO(A) knockout mice are more susceptible to seizures but show reduced epileptogenesis. ( Dyck, RH; Radford, KS; Seif, I; Teskey, GC, 2004) |
| "It remains unclear whether the seizures result from aberrant neuronal placement, disruption of intrinsic properties of neurons, or both." | 1.32 | Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans. ( Braden, AL; Caldwell, GA; Caldwell, KA; Locke, CJ; Williams, SN, 2004) |
| "increases seizure susceptibility." | 1.32 | Continuous increase of epileptogenic effects following application of proteolytic enzymes (buccal ganglia of Helix pomatia). ( Altrup, U; Joschko, A; Ure, A, 2004) |
| "Epilepsy is one of the most common but genetically complex neurological disorders in humans." | 1.32 | Genetic and phenotypic analysis of seizure susceptibility in PL/J mice. ( Ernest, S; Frankel, WN; Friedman, L; Gallaugher, L; Kitami, T; Nadeau, JH, 2004) |
| "Ketogenic diets have been used to treat seizure disorders of children resistant to conventional anti-epileptic drug treatment." | 1.32 | Ketogenic diet fed rats have low levels of S100B in cerebrospinal fluid. ( Gonçalves, CA; Gonçalves, D; Leite, M; Mendez, A; Oliveira, DL; Perry, ML; Pires, C; Portela, LV; Ribeiro, L; Tramontina, F; Wofchuk, ST; Ziegler, DR, 2004) |
| "are used for the treatment of epilepsy by traditional healers in subcontinent." | 1.31 | In vitro inhibition of pentylenetetrazole and bicuculline-induced epileptiform activity in rat hippocampal pyramidal neurons by aqueous fraction isolated from Delphinium denudatum. ( Choudhary, MI; DeLorenzo, RJ; Rahman, AU; Raza, M; Shaheen, F; Sombati, S, 2002) |
| "Cysteamine pre-treatment decreased baseline CA1 population spike amplitude following high intensity stimulation of Schaffer collaterals." | 1.31 | Cysteamine pre-treatment reduces pentylenetetrazol-induced plasticity and epileptiform discharge in the CA1 region of rat hippocampal slices. ( Fathollahi, Y; Hajizadeh, S; Mirnajafizadeh, J; Rostampour, M; Semnanian, S; Shafizadeh, M, 2002) |
| "Since epilepsy is assumed to be a disease syndrome which is probably manifested by abnormal expression of multifocal genes, determination of the role of each chromosomal locus in the provocation of seizure activity is important." | 1.31 | Gene mapping of SEZ group genes and determination of pentylenetetrazol susceptible quantitative trait loci in the mouse chromosome. ( Jin, W; Kajiwara, K; Maruyama, C; Naramoto, F; Ohguchi, H; Sugaya, A; Sugaya, E; Tsuda, T; Wakana, S; Yokote, N, 2000) |
| "In contrast, PTZ induced seizure did not increase BDNF protein levels in either tissue." | 1.31 | Seizures and sensory stimulation result in different patterns of brain derived neurotrophic factor protein expression in the barrel cortex and hippocampus. ( Mack, KJ; Nanda, SA, 2000) |
| "However, after kindled seizures, GluRAs block the monosynaptic excitatory postsynaptic potential (EPSP) and isolate a monosynaptic inhibitory postsynaptic potential (IPSP), suggesting that mossy fibers release GABA." | 1.31 | Seizures induce simultaneous GABAergic and glutamatergic transmission in the dentate gyrus-CA3 system. ( Gutiérrez, R, 2000) |
| "These results suggest that NPY reduces seizures of hippocampal origin through activation of Y(5) receptors." | 1.31 | Neuropeptide Y and epilepsy: varying effects according to seizure type and receptor activation. ( Benmaamar, R; Carnahan, J; Depaulis, A; Larmet, Y; Marescaux, C; Nadi, S; Reibel, S, 2001) |
| "Palmitone did not produce motor incoordination and loss of righting reflex which are used as signs of neurological impairment." | 1.31 | Anticonvulsant properties and bio-guided isolation of palmitone from leaves of Annona diversifolia. ( Cedillo-Portugal, E; González-Trujano, ME; Hong, E; Navarrete, A; Reyes, B, 2001) |
| "Testosterone's (T) anti-seizure effects may be mediated in part by actions of its 5alpha-reduced metabolites." | 1.31 | Testosterone reduces pentylenetetrazole-induced ictal activity of wildtype mice but not those deficient in type I 5alpha-reductase. ( Frye, CA; Harney, JP; Rhodes, ME; Walf, AA, 2001) |
| "Diazepam (DZP) was intraperitoneally injected (0." | 1.30 | Diazepam--its effects on the development of pentylenetetrazol kindling, related learning impairments, and neuronal cell loss. ( Becker, A; Grecksch, GA; Tiedge, A, 1997) |
| " We demonstrate that jerky has a dosage-sensitive function (haploinsufficiency) in brain and that this sensitivity to reduced jerky dosage could explain the occurrence of seizures in hemizygotes." | 1.30 | Sensitivity to jerky gene dosage underlies epileptic seizures in mice. ( Donovan, GP; Gal, J; Gudas, LJ; Harden, C; Ho, L; Sibille, E; Toth, M; Trifiletti, R, 1997) |
| "The clinical signs of ivermectin toxicity were determined in 6 groups of 10 epileptic and 8 non-epileptic chickens for 72 h after dosing with sc injections of 5." | 1.29 | Clinical signs of ivermectin toxicity and the efficacy of antigabaergic convulsants as antidotes for ivermectin poisoning in epileptic chickens. ( Crichlow, EC; Kim, JS, 1995) |
| "Dexmedetomidine (DEX) is a highly selective alpha 2 agonist with marked sedative and analgesic properties thought to be mediated via reduction of central noradrenergic transmission." | 1.29 | Dexmedetomidine decreases seizure threshold in a rat model of experimental generalized epilepsy. ( McPherson, RW; Mirski, MA; Rossell, LA; Traystman, RJ, 1994) |
| " Pretreatment of rats with venom increased the minimum convulsant dose of picrotoxin, impaired convulsion generalization and displaced to the left the dose-response curve for picrotoxin." | 1.29 | Behavioural and electroencephalographic effects of Tityus serrulatus scorpion venom in rats. ( Dorce, VA; Sandoval, MR, 1993) |
| "Pentylenetetrazole was used to induce epileptic activity." | 1.29 | Alterations of neuronal fibers after epileptic activity induced by pentylenetetrazole: fine structure investigated by calcium cytochemistry and neurobiotin labeling (buccal ganglia, Helix pomatia). ( Altrup, U; Speckmann, EJ; Wiemann, M; Wittkowski, W, 1996) |
| "Pretreatment with felbamate at either dose prevented the progression of rank of seizures during chronic treatment with PTZ." | 1.29 | Anticonvulsant effect of felbamate in the pentylenetetrazole kindling model of epilepsy in the rat. ( Carboni, G; Corda, MG; Feldman, A; Frau, V; Giorgi, O; Orlandi, M; Valentini, V, 1996) |
| "In posture change, the first signs of seizure appeared after age 6 weeks with maximal frequency at 8-9 weeks." | 1.28 | Intrinsic and drug-induced seizures of adult and developing gerbils. ( Ito, M; Kudo, T; Mizutani, A; Seto-Ohshima, A, 1992) |
| "After daily repeated PTZ convulsions, a significant increase of A1 receptors by 26% appeared also in cortex, while the changes of A1 receptors observed in the other brain areas after a single PTZ convulsion were maintained in almost the same range." | 1.28 | Alterations of A1 adenosine receptors in different mouse brain areas after pentylentetrazol-induced seizures, but not in the epileptic mutant mouse 'tottering'. ( Angelatou, F; Kostopoulos, G; Pagonopoulou, O, 1990) |
| "Isatin has recently been identified in rat tissues and normal human urine where it constitutes the major part of the endogenous monoamine oxidase inhibitor, tribulin." | 1.28 | Isatin and tribulin concentrations are increased in rabbit brain but not liver following pentylenetetrazole administration. ( Clow, A; Davidson, J; Glover, V; Halket, JM; Milton, AS; Sandler, M; Watkins, PJ, 1989) |
| "Evans blue was used as a visual indicator of BBB integrity." | 1.28 | Age-related changes in regional patterns of blood-brain barrier breakdown during epileptiform seizures induced by pentylenetetrazol. ( Ates, N; Ziylan, YZ, 1989) |
| "In audiogenic seizure mice, glial CA activity is increased and glial anion transport is reduced." | 1.27 | Ionic and acid-base regulation of neurons and glia during seizures. ( Chen, CF; Chow, SY; Engstrom, FL; Kemp, JW; White, HS; Woodbury, DM, 1984) |
| "Propranolol was found to potentiate the possible models of human absences--spontaneous episodes, RMA and minimal clonic seizures." | 1.27 | Influence of propranolol on rhythmic electrocorticographic activity induced by metrazol in rats. ( Chocholová, L; Mares, P; Müller, M, 1986) |
| "When kainic acid was included in the dialysis buffer, taurine was doubled in taurine-supplemented kittens, but it was only slightly affected in deficient animals." | 1.27 | Pentylenetetrazol seizure threshold and extracellular levels of cortical amino acids in taurine-deficient kittens. ( Lehmann, A, 1987) |
| "Autonomic dysfunction, including arrhythmias, has been shown to be associated with epileptogenic activity." | 1.27 | The role of enkephalins in the production of epileptogenic activity and autonomic dysfunction: origin of arrhythmia and sudden death in the epileptic patient? ( Kraras, CM; Lathers, CM; Tumer, N, 1987) |
| "Phenobarbital pretreatment depressed heart rate, blood pressure and postganglionic cardiac sympathetic neural discharge." | 1.27 | Effect of phenobarbital pretreatment on cardiac neural discharge and pentylenetetrazol-induced epileptogenic activity in the cat. ( Carnel, SB; Lathers, CM; Schraeder, PL, 1985) |
| "In this study the pentetrazole seizure threshold of dogs was compared with the concentration of GABA in the CSF and blood plasma." | 1.26 | Relationship between GABA concentrations in cerebrospinal fluid and seizure excitability. ( Löscher, W, 1982) |
| "Cardiazol induced seizures in rabbits showed that the highest oxypurine concentrations can be detected in the CSF 1 hour after the convulsions." | 1.26 | Increased nucleotide catabolism after cerebral convulsions. ( Dörner, K; Manzke, H; Staemmler, W, 1981) |
| "Like haloperidol-pretreated rats they were able to maintain uncomfortable postures on the vertical grid or horizontal bar; although signs of rigidity were noticed, the rats would fail to remain self-supporting when placed across metal bookends ("bridge" test)." | 1.26 | Pharmacologic analysis of the postictal immobility syndrome in the rat. ( Kofman, O; Mintz, M; Myslobodsky, MS, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 181 (21.12) | 18.7374 |
| 1990's | 83 (9.68) | 18.2507 |
| 2000's | 174 (20.30) | 29.6817 |
| 2010's | 256 (29.87) | 24.3611 |
| 2020's | 163 (19.02) | 2.80 |
| Authors | Studies |
|---|---|
| Ping, X | 1 |
| Chai, Z | 1 |
| Wang, W | 6 |
| Ma, C | 3 |
| White, FA | 1 |
| Jin, X | 1 |
| Aghaie, F | 1 |
| Rajabi, M | 1 |
| Hosseini, A | 2 |
| Moradifar, F | 1 |
| Koneshlou, S | 1 |
| Liu, CH | 1 |
| Liao, WC | 1 |
| Li, HH | 1 |
| Tseng, LH | 1 |
| Wang, WH | 1 |
| Tung, H | 1 |
| Lin, PJ | 1 |
| Jao, HT | 1 |
| Liu, WY | 1 |
| Hung, CS | 1 |
| Lin, CL | 1 |
| Ho, YJ | 1 |
| Shahpari, MS | 1 |
| Namavar, MRN | 1 |
| Kamali Dolatabadi, LKD | 1 |
| Aligholi, HA | 1 |
| Emamghoreishi, ME | 1 |
| Feja, M | 1 |
| Meller, S | 1 |
| Deking, LS | 1 |
| Kaczmarek, E | 1 |
| During, MJ | 1 |
| Silverman, RB | 1 |
| Gernert, M | 2 |
| Wang, L | 9 |
| Ding, J | 2 |
| Zhu, C | 1 |
| Guo, B | 1 |
| Yang, W | 1 |
| He, W | 1 |
| Li, X | 9 |
| Wang, Y | 14 |
| Li, W | 3 |
| Wang, F | 2 |
| Sun, T | 1 |
| Ren, Q | 1 |
| Gao, D | 1 |
| Mou, L | 1 |
| Zhang, S | 4 |
| Zhang, M | 1 |
| Li, N | 1 |
| Sik, A | 2 |
| Jin, M | 3 |
| Liu, K | 2 |
| Siddiqui, MA | 2 |
| Akhter, J | 2 |
| Junaid Bashir, D | 1 |
| Manzoor, S | 1 |
| Rastogi, S | 2 |
| Arora, I | 2 |
| Aggarwal, NB | 2 |
| Samim, M | 2 |
| de Calbiac, H | 1 |
| Dabacan, A | 1 |
| Muresan, R | 1 |
| Kabashi, E | 1 |
| Ciura, S | 1 |
| Kozioł, E | 1 |
| Jóźwiak, K | 1 |
| Budzyńska, B | 1 |
| de Witte, PAM | 2 |
| Copmans, D | 2 |
| Skalicka-Woźniak, K | 1 |
| Zhang, X | 4 |
| Wu, S | 5 |
| Guo, C | 3 |
| Guo, K | 3 |
| Hu, Z | 3 |
| Peng, J | 3 |
| Zhang, Z | 3 |
| Li, J | 10 |
| Li, G | 3 |
| Cheng, Y | 2 |
| Lu, Y | 3 |
| Jia, Z | 1 |
| Yang, X | 1 |
| Guo, W | 1 |
| Pei, L | 1 |
| Wu, J | 1 |
| Hou, Z | 1 |
| Chen, L | 10 |
| Lian, C | 1 |
| Meng, Q | 1 |
| Zhang, C | 7 |
| Huang, L | 1 |
| Yu, H | 4 |
| Uttl, L | 1 |
| Hložek, T | 1 |
| Mareš, P | 9 |
| Páleníček, T | 1 |
| Kubová, H | 3 |
| El-Hefnawy, MA | 1 |
| Yehia, A | 2 |
| Nashar, EME | 1 |
| Saad, S | 2 |
| Obydah, W | 2 |
| Alghamdi, MA | 2 |
| Alasmari, WA | 2 |
| Hussein, AM | 3 |
| El Nashar, EM | 1 |
| Maryoud, A | 1 |
| Kiwan, NA | 1 |
| Wang, X | 10 |
| Guo, Z | 1 |
| Mei, D | 1 |
| Zhang, Y | 11 |
| Zhao, S | 1 |
| Hu, S | 2 |
| Luo, S | 1 |
| Wang, Q | 2 |
| Gao, C | 1 |
| Essawy, AE | 1 |
| El-Sayed, SA | 1 |
| Tousson, E | 1 |
| Abd El-Gawad, HS | 1 |
| Alhasani, RH | 1 |
| Abd Elkader, HAE | 1 |
| Torun, IE | 4 |
| Kılınc, YB | 1 |
| Kilinc, E | 4 |
| Pala, M | 1 |
| Meral, I | 2 |
| Pala Acikgoz, N | 1 |
| Gorucu Yilmaz, Ş | 1 |
| Taslidere, E | 1 |
| Okur, SK | 1 |
| Acar, S | 1 |
| Akbas, F | 2 |
| Wu, L | 1 |
| Qin, Y | 1 |
| Yuan, H | 1 |
| Zhu, Y | 2 |
| Hu, A | 1 |
| Nishi, T | 1 |
| Metcalf, CS | 1 |
| Fujimoto, S | 1 |
| Hasegawa, S | 1 |
| Miyamoto, M | 1 |
| Sunahara, E | 1 |
| Watanabe, S | 1 |
| Kondo, S | 1 |
| White, HS | 7 |
| Huang, Y | 4 |
| Xu, H | 2 |
| Wang, P | 2 |
| Gu, R | 1 |
| Xu, Y | 1 |
| Wang, J | 4 |
| Qiao, S | 1 |
| Shi, D | 1 |
| Gao, Z | 1 |
| Lu, HC | 1 |
| Chang, WJ | 1 |
| Wei Huang, AC | 1 |
| Shyu, BC | 1 |
| Asad, M | 1 |
| Hoda, U | 1 |
| Zhou, L | 1 |
| Gao, Y | 1 |
| Lu, H | 2 |
| Liu, W | 1 |
| Xu, X | 2 |
| Xing, B | 1 |
| Liang, X | 1 |
| Wang, N | 2 |
| Jiang, X | 3 |
| Zhao, Q | 1 |
| Karabulut, S | 1 |
| Filiz, AK | 1 |
| Akkaya, R | 1 |
| Hosseinzadeh, A | 1 |
| Dehdashtian, E | 1 |
| Jafari-Sabet, M | 1 |
| Mehrzadi, S | 1 |
| Wen, Y | 2 |
| Zhang, G | 1 |
| Liu, L | 2 |
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| Ortiz, WR | 1 |
| Gilbert, JC | 1 |
| Vizioli, R | 1 |
| Pastena, L | 1 |
| Fermum, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Sodium-Glucose Cotransporter-2 Inhibitors: A Potential Novel Treatment for Epilepsy[NCT05512130] | Early Phase 1 | 18 participants (Anticipated) | Interventional | 2022-08-17 | Recruiting | ||
| Focused Ultrasound Neuromodulation for Treatment of Temporal Lobe Epilepsy[NCT03657056] | 0 participants (Actual) | Interventional | 2022-01-31 | Withdrawn (stopped due to No subjects enrolled and IRB record was closed) | |||
| Effect of the Treatment of Vitamin D Deficiency in Drug-resistant Epilepsy[NCT03475225] | Phase 3 | 400 participants (Anticipated) | Interventional | 2018-04-30 | Not yet recruiting | ||
| STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis[NCT05603702] | Phase 1 | 24 participants (Anticipated) | Interventional | 2023-03-17 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
32 reviews available for pentylenetetrazole and Epilepsy
| Article | Year |
|---|---|
Zebrafish as an Innovative Tool for Epilepsy Modeling: State of the Art and Potential Future Directions.
Topics: Animals; Anticonvulsants; Child; Disease Models, Animal; Epilepsy; Humans; Pentylenetetrazole; Seizu | 2023 |
Chemically-induced epileptic seizures in zebrafish: A systematic review.
Topics: Animals; Anticonvulsants; Epilepsy; Pentylenetetrazole; Reproducibility of Results; Seizures; Zebraf | 2023 |
Validated animal models for antiseizure drug (ASD) discovery: Advantages and potential pitfalls in ASD screening.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; | 2020 |
[Neurobehavioral Comorbidities in Pentylenetetrazol-kindled Mice and Role of the α4β2 Nicotinic Acetylcholine Receptor].
Topics: Animals; Cell Adhesion Molecules, Neuronal; Disease Models, Animal; Down-Regulation; Epilepsy; Isoxa | 2019 |
PTZ kindling model for epileptogenesis, refractory epilepsy, and associated comorbidities: relevance and reliability.
Topics: Animals; Anticonvulsants; Cognitive Dysfunction; Depression; Disease Models, Animal; Drug Resistance | 2021 |
The microRNA miR-124 suppresses seizure activity and regulates CREB1 activity.
Topics: Action Potentials; Animals; Cyclic AMP Response Element-Binding Protein; Epilepsy; Gene Expression R | 2016 |
The Search for New Screening Models of Pharmacoresistant Epilepsy: Is Induction of Acute Seizures in Epileptic Rodents a Suitable Approach?
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Electroshock; Epilep | 2017 |
Assessing the link between omega-3 fatty acids, cardiac arrest, and sudden unexpected death in epilepsy.
Topics: Animals; Anticonvulsants; Arrhythmias, Cardiac; Cardiotonic Agents; Convulsants; Death, Sudden, Card | 2009 |
In vivo experimental models of epilepsy.
Topics: Aluminum Hydroxide; Animals; Bicuculline; Cobalt; Convulsants; Disease Models, Animal; Electroshock; | 2010 |
[Impaired memory following repeated pentylenetetrazol treatments in kindled mice].
Topics: Animals; Disease Models, Animal; Epilepsy; Kindling, Neurologic; Memory; Memory Disorders; Mice; Mot | 2012 |
Do preclinical seizure models preselect certain adverse effects of antiepileptic drugs.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Electro | 2002 |
THE EEG IN AEROSPACE MEDICINE.
Topics: Aerospace Medicine; Biomedical Research; Electroencephalography; Epilepsy; Humans; Hyperventilation; | 1964 |
Epileptogenicity and epileptic activity: mechanisms in an invertebrate model nervous system.
Topics: Animals; Anticonvulsants; Epilepsy; Ganglia, Invertebrate; Helix, Snails; Humans; Membrane Potential | 2004 |
Androgens in the hippocampus can alter, and be altered by, ictal activity.
Topics: Androgens; Animals; Disease Models, Animal; Epilepsy; Female; Hippocampus; Humans; Male; Pentylenete | 2004 |
Synergistic combinations of anticonvulsant agents: what is the evidence from animal experiments?
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug I | 2007 |
Modulation of presynaptic gamma aminobutyric acid release by prostaglandin E2: explanation for epileptogenic activity and dysfunction in autonomic cardiac neural discharge leading to arrhythmias?
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Cats; Dinoprostone; Epilepsy; gamma-Aminobu | 1984 |
Cellular physiology of epileptogenic phenomena. A hint for future therapy by a herbal mixture.
Topics: Animals; Disease Models, Animal; Epilepsy; Forecasting; Membrane Potentials; Mice; Neurons; Pentylen | 1995 |
Clinical significance of animal seizure models and mechanism of action studies of potential antiepileptic drugs.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Synergism; Drug | 1997 |
Animal models used in the screening of antiepileptic drugs.
Topics: Acoustic Stimulation; Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, P | 2001 |
Behavioral and electroencephalographic manifestations of avian epilepsy: a review of the literature.
Topics: Animals; Behavior, Animal; Bird Diseases; Birds; Brain; Chickens; Coturnix; Electric Stimulation; El | 1977 |
[Neurophysiology of epileptic seizures (author's transl)].
Topics: Animals; Cell Membrane Permeability; Cerebral Cortex; Electrophysiology; Epilepsy; Evoked Potentials | 1978 |
Contributions of electroencephalography and electrocorticography to the neurosurgical treatment of the epilepsies.
Topics: Amobarbital; Bemegride; Cerebral Cortex; Electric Stimulation; Electrodes; Electrodes, Implanted; El | 1975 |
Epileptogenesis: contributions of calcium ions and antiepileptic calcium antagonists.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Electroencephalography; Epilep | 1992 |
Cellular physiology of epileptogenic phenomena and its application to therapy against intractable epilepsy.
Topics: Animals; Calcium; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Drugs, Chinese Herbal; E | 1991 |
The neurophysiological basis of epileptic activity: a condensed overview.
Topics: Animals; Brain; Cats; Cerebral Cortex; Electroencephalography; Epilepsy; Evoked Potentials; Humans; | 1991 |
Epilepsy and the GABA-hypothesis a brief review and some examples.
Topics: Animals; Brain; Carbolines; Convulsants; Epilepsy; GABA Antagonists; gamma-Aminobutyric Acid; Guanid | 1990 |
[GABAergic theory of epilepsy].
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Brain; Dogs; E | 1986 |
Benzodiazepines in the treatment of epilepsy. A review.
Topics: Adult; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Disease Models, Animal; Eclampsia; Elec | 1973 |
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials | 1969 |
[Biochemistry of epilepsy].
Topics: Acetylcholine; Aminobutyrates; Animals; Brain; Electroencephalography; Epilepsy; Glutamates; Glutami | 1968 |
[Evaluation of the activation methods in epilepsy].
Topics: Adult; Age Factors; Animals; Bemegride; Cats; Cerebral Cortex; Child; Electric Stimulation; Electroe | 1967 |
The electroencephalogram as a diagnostic aid in neurosurgery: a review.
Topics: Adult; Age Factors; Amobarbital; Brain Diseases; Brain Injuries; Brain Neoplasms; Child; Child, Pres | 1969 |
7 trials available for pentylenetetrazole and Epilepsy
| Article | Year |
|---|---|
A comparison of extracellular excitatory amino acids release inhibition of acute lamotrigine and topiramate treatment in the hippocampus of PTZ-kindled epileptic rats.
Topics: Animals; Anticonvulsants; Epilepsy; Excitatory Amino Acid Agents; Excitatory Amino Acid Antagonists; | 2013 |
Enantioselective pharmacodynamic and pharmacokinetic analysis of two chiral CNS-active carbamate derivatives of valproic acid.
Topics: Animals; Anticonvulsants; Area Under Curve; Carbamates; Central Nervous System; Convulsants; Disease | 2014 |
Ictal brain SPET during seizures pharmacologically provoked with pentylenetetrazol: a new diagnostic procedure in drug-resistant epileptic patients.
Topics: Adolescent; Adult; Cysteine; Drug Resistance; Electroencephalography; Epilepsy; Feasibility Studies; | 2002 |
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials | 1969 |
Clinical studies on the EEG-activating effects of a new central stimulant, sodium-beta, beta-pentamethylene-gamma-hydroxybutyrate.
Topics: Adolescent; Adult; Aged; Bemegride; Central Nervous System; Central Nervous System Stimulants; Child | 1965 |
[Lymphogenous encephalopathy: a new clinical picture and its management].
Topics: Adult; Animals; Brain Diseases; Cerebrospinal Fluid; Cerebrovascular Circulation; Child; Clinical Tr | 1967 |
Comparable EEG activation by megimide and metrazol.
Topics: Adolescent; Adult; Aged; Bemegride; Body Weight; Clinical Trials as Topic; Electroencephalography; E | 1966 |
819 other studies available for pentylenetetrazole and Epilepsy
| Article | Year |
|---|---|
Blocking receptor for advanced glycation end products (RAGE) or toll-like receptor 4 (TLR4) prevents posttraumatic epileptogenesis in mice.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Post-Traumatic; Mice; Mice, Knockout; Pentylene | 2021 |
Preventive Effects of Sinigrin Against the Memory Deterioration in the Pentylenetetrazole-Kindled Male Wistar Rats: Possible Modulation of NLRP3 Pathway.
Topics: Animals; Epilepsy; Glucosinolates; Inflammation; Male; NLR Family, Pyrin Domain-Containing 3 Protein | 2022 |
Treatment with the combination of clavulanic acid and valproic acid led to recovery of neuronal and behavioral deficits in an epilepsy rat model.
Topics: Animals; Clavulanic Acid; Epilepsy; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rats, Wist | 2021 |
Morphological changes in the substantia nigra pars reticulata of the mice during kindling.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy; Humans; Kindling, Neurologic; Male; Mice; Ne | 2021 |
OV329, a novel highly potent γ-aminobutyric acid aminotransferase inactivator, induces pronounced anticonvulsant effects in the pentylenetetrazole seizure threshold test and in amygdala-kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Epilepsy; Female; gamma-Aminobutyric Acid; Humans; Kindling, Neu | 2021 |
Semaglutide attenuates seizure severity and ameliorates cognitive dysfunction by blocking the NLR family pyrin domain containing 3 inflammasome in pentylenetetrazole‑kindled mice.
Topics: Animals; Apoptosis; Cell Line; Cognitive Dysfunction; Cytokines; Disease Models, Animal; Epilepsy; G | 2021 |
Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cluster Analysis; Disease Models, Animal; Epilepsy; Gene | 2021 |
Resveratrol loaded nanoparticles attenuate cognitive impairment and inflammatory markers in PTZ-induced kindled mice.
Topics: Animals; Antioxidants; Cognitive Dysfunction; Collagen; Disease Models, Animal; Epilepsy; Glutathion | 2021 |
Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Humans; Pentylenetetrazole; Seizures; Zebrafish | 2021 |
Comparative Antiseizure Analysis of Diverse Natural Coumarin Derivatives in Zebrafish.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Convulsants; Coumarins; Epilepsy; Mesencepha | 2021 |
Vitamin E Exerts Neuroprotective Effects in Pentylenetetrazole Kindling Epilepsy via Suppression of Ferroptosis.
Topics: Animals; Epilepsy; Ferroptosis; Kindling, Neurologic; Male; Neuroprotective Agents; Pentylenetetrazo | 2022 |
Baicalin suppresses neuron autophagy and apoptosis by regulating astrocyte polarization in pentylenetetrazol-induced epileptic rats and PC12 cells.
Topics: Animals; Apoptosis; Astrocytes; Autophagy; Cell Polarity; Cerebral Cortex; Epilepsy; Flavonoids; Mal | 2022 |
Discovery of 7-alkyloxy- [1,2,4] triazolo[1,5-a] pyrimidine derivatives as selective positive modulators of GABA
Topics: Animals; Anticonvulsants; Cells, Cultured; Dose-Response Relationship, Drug; Drug Discovery; Electro | 2022 |
Anticonvulsive Effects and Pharmacokinetic Profile of Cannabidiol (CBD) in the Pentylenetetrazol (PTZ) or N-Methyl-D-Aspartate (NMDA) Models of Seizures in Infantile Rats.
Topics: Animals; Anticonvulsants; Brain; Cannabidiol; Disease Models, Animal; Epilepsy; Male; N-Methylaspart | 2021 |
Effect of vanillic acid on pentylenetetrazole-kindled rats: Nrf2/HO-1, IGF-1 signaling pathways cross talk.
Topics: Animals; Anticonvulsants; Antioxidants; Convulsants; Disease Models, Animal; Epilepsy; Heme Oxygenas | 2022 |
Effects of Stevia rebaudiana Bertoni extracts in the rat model of epilepsy induced by pentylenetetrazol: Sirt-1, at the crossroads between inflammation and apoptosis.
Topics: Animals; Anticonvulsants; Antioxidants; Apoptosis; Convulsants; Disease Models, Animal; Epilepsy; Hi | 2022 |
The GluN2B-Trp373 NMDA Receptor Variant is Associated with Autism-, Epilepsy-Related Phenotypes and Reduces NMDA Receptor Currents in Rats.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Epilepsy; Pentylenetetrazole; Phenotype; Rats; | 2022 |
Anti-kindling effect of Ginkgo biloba leaf extract and L-carnitine in the pentylenetetrazol model of epilepsy.
Topics: Animals; Antioxidants; Carnitine; Epilepsy; Ginkgo biloba; Glutathione Peroxidase; Male; Oxidative S | 2022 |
Endogenous and exogenous serotonin, but not sumatriptan, ameliorate seizures and neuroinflammation in the pentylenetetrazole-induced seizure model in rats.
Topics: Animals; Anticonvulsants; Epilepsy; Fluoxetine; Humans; Interleukin-6; Male; Neuroinflammatory Disea | 2022 |
Pentylenetetrazole-induced kindling rat model: miR-182 and miR-27b-3p mediated neuroprotective effect of thymoquinone in the hippocampus.
Topics: Animals; Benzoquinones; Epilepsy; Hippocampus; Kindling, Neurologic; Male; MicroRNAs; Neuroprotectiv | 2022 |
Anti-inflammatory and neuroprotective effects of insulin-like growth factor-1 overexpression in pentylenetetrazole (PTZ)-induced mouse model of chronic epilepsy.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Epilepsy; Hippocampus; Insulin-Like Growt | 2022 |
Anticonvulsive properties of soticlestat, a novel cholesterol 24-hydroxylase inhibitor.
Topics: Animals; Anticonvulsants; Cholesterol 24-Hydroxylase; Disease Models, Animal; Epilepsy; Kindling, Ne | 2022 |
Identification of Guaifenesin-Andrographolide as a Novel Combinatorial Drug Therapy for Epilepsy Using Network Virtual Screening and Experimental Validation.
Topics: Anticonvulsants; Diterpenes; Electroshock; Epilepsy; Guaifenesin; Humans; Pentylenetetrazole; Seizur | 2022 |
Detection of pentylenetetrazol-induced seizure activity in the 19-21 Hz beta range using a magnetic coil induction method.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy; Magnetic Phenomena; Mice; Pentyle | 2022 |
Resveratrol-Loaded Glutathione-Coated Collagen Nanoparticles Attenuate Acute Seizures by Inhibiting HMGB1 and TLR-4 in the Hippocampus of Mice.
Topics: Animals; Anticonvulsants; Collagen; Epilepsy; Glutathione; Hippocampus; HMGB1 Protein; Mice; Nanopar | 2022 |
Topics: Alzheimer Disease; Animals; Anticonvulsants; Cognitive Dysfunction; Disease Models, Animal; Epilepsy | 2023 |
Thiamine alleviates cognitive impairment and epileptogenesis by relieving brain inflammation in PTZ-induced kindling rat model.
Topics: Animals; Cognitive Dysfunction; Cyclooxygenase 2; Encephalitis; Epilepsy; Kindling, Neurologic; Male | 2022 |
The Effects of Vitamin D3 and Melatonin Combination on Pentylenetetrazole- induced Seizures in Mice.
Topics: Animals; Anticonvulsants; Cholecalciferol; Disease Models, Animal; Epilepsy; Melatonin; Mice; Pentyl | 2022 |
HAP1 interacts with 14-3-3 to regulate epileptic seizure via GABA
Topics: 14-3-3 Proteins; Animals; Epilepsy; gamma-Aminobutyric Acid; Nerve Tissue Proteins; Pentylenetetrazo | 2022 |
Protective Effects of Intranasally Administrated Oxytocin-Loaded Nanoparticles on Pentylenetetrazole-Kindling Epilepsy in Terms of Seizure Severity, Memory, Neurogenesis, and Neuronal Damage.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Male; Nanoparticles; Neurogenesis; Neurons; | 2022 |
miR-146a/KLF4 axis in epileptic mice: A novel regulator of synaptic plasticity involving STAT3 signaling.
Topics: Animals; Antagomirs; Epilepsy; Mice; MicroRNAs; Neuronal Plasticity; Pentylenetetrazole; Seizures; S | 2022 |
Pentylenetetrazole-induced seizures cause impairment of memory acquisition and consolidation in zebrafish (Danio rerio).
Topics: Animals; Anticonvulsants; Epilepsy; Memory; Pentylenetetrazole; Seizures; Zebrafish | 2022 |
Evaluation of Resveratrol and Piceatannol Anticonvulsant Potential in Adult Zebrafish (Danio rerio).
Topics: Animals; Anticonvulsants; Caspase 3; Diazepam; Epilepsy; Interleukin-1beta; Neuroprotective Agents; | 2022 |
4-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Male; Neuroprotective Agents; Pentylenet | 2022 |
Alterations of Serum Magnesium Concentration in Animal Models of Seizures and Epilepsy-The Effects of Treatment with a GPR39 Agonist and Knockout of the
Topics: Animals; Disease Models, Animal; Epilepsy; Magnesium; Mice; Mice, Knockout; Pentylenetetrazole; Rece | 2022 |
The protective effect of vitamin U on pentylenetetrazole-induced brain damage in rats.
Topics: Alkaline Phosphatase; Animals; Antioxidants; Brain; Brain Injuries; Epilepsy; Glutathione; Male; Nit | 2022 |
Proanthocyanidins alleviate pentylenetetrazole-induced epileptic seizures in mice via the antioxidant activity.
Topics: Animals; Anticonvulsants; Antioxidants; Epilepsy; Mice; NF-E2-Related Factor 2; Oxidative Stress; Pe | 2022 |
Insights into the development of pentylenetetrazole-induced epileptic seizures from dynamic metabolomic changes.
Topics: Alanine; Animals; Anticonvulsants; Asparagine; Citrates; Creatine; Creatinine; Disease Models, Anima | 2022 |
An involvement of COX and 5-LOX pathways in the penicillin- and pentylenetetrazole (PTZ)-induced epilepsy models.
Topics: Animals; Disease Models, Animal; Epilepsy; Penicillins; Pentylenetetrazole; Rats; Rats, Wistar | 2023 |
Ferulic acid inhibits catamenial epilepsy through modulation of female hormones.
Topics: Adult; Animals; Corticosterone; Epilepsy; Estradiol; Female; Finasteride; Horses; Humans; Mice; Neur | 2022 |
Morin offsets PTZ-induced neuronal degeneration and cognitive decrements in rats: The modulation of TNF-α/TNFR-1/RIPK1,3/MLKL/PGAM5/Drp-1, IL-6/JAK2/STAT3/GFAP and Keap-1/Nrf-2/HO-1 trajectories.
Topics: Animals; Cognition; Epilepsy; Flavonoids; Hippocampus; Interleukin-6; Janus Kinase 2; Kindling, Neur | 2022 |
Anti-seizure effect of zinc on PTZ-induced epilepsy in rat model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Hippocampus; Mice; Pentylenetetrazole; R | 2022 |
The Anti-Seizure Effect of Liraglutide on Ptz-Induced Convulsions Through its Anti-Oxidant and Anti-Inflammatory Properties.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Antioxidants; Disease Models, Animal; Epilepsy; | 2023 |
Seratrodast, a thromboxane A2 receptor antagonist, inhibits neuronal ferroptosis by promoting GPX4 expression and suppressing JNK phosphorylation.
Topics: Animals; Benzoquinones; Epilepsy; Ferroptosis; Glutathione; Heptanoic Acids; Mice; Pentylenetetrazol | 2022 |
Investigation into Antiepileptic Effect of Ganoderic Acid A and Its Mechanism in Seizure Rats Induced by Pentylenetetrazole.
Topics: Animals; Anticonvulsants; bcl-2-Associated X Protein; Caspase 3; Epilepsy; Heptanoic Acids; Lanoster | 2022 |
The protective effect of inhibiting mitochondrial fission on the juvenile rat brain following PTZ kindling through inhibiting the BCL2L13/LC3 mitophagy pathway.
Topics: Animals; Brain Injuries; Caspase 3; Dimethyl Sulfoxide; Epilepsy; Hippocampus; Kindling, Neurologic; | 2023 |
Decreased Spire2 Expression is Involved in Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; | 2022 |
Aerobic exercise, alone or combined with an anti-inflammatory drug, reduces the severity of epileptic seizures and levels of central pro-inflammatory cytokines in an animal model of epileptic seizures.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Diazepam; Disease Models, Animal; Epilepsy; Exercise; | 2022 |
Preclinical efficacy of cannabidiol for the treatment of early-life seizures.
Topics: Animals; Anticonvulsants; Cannabidiol; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Rats | 2022 |
Imatinib Attenuates Pentylenetetrazole Kindled and Pilocarpine Induced Recurrent Spontaneous Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Imatinib Mesylate; Mice; Pentylenetetraz | 2023 |
Chemo-kindling in adult zebrafish alters spatial cognition but not social novelty recognition.
Topics: Animals; Anticonvulsants; Cognition; Epilepsy; Kindling, Neurologic; Pentylenetetrazole; Zebrafish | 2023 |
3BDO Alleviates Seizures and Improves Cognitive Function by Regulating Autophagy in Pentylenetetrazol (PTZ)-Kindled Epileptic Mice Model.
Topics: 4-Butyrolactone; Animals; Autophagy; Cognition; Disease Models, Animal; Epilepsy; Hippocampus; Kindl | 2022 |
Overexpression of Homer1b/c induces valproic acid resistance in epilepsy.
Topics: Animals; Anticonvulsants; Epilepsy; Mice; Pentylenetetrazole; Rats; Receptor, Metabotropic Glutamate | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effect of valproate on sleep patterns disturbed by epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rat | 2023 |
Effect of valproate on sleep patterns disturbed by epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rat | 2023 |
Effect of valproate on sleep patterns disturbed by epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rat | 2023 |
Effect of valproate on sleep patterns disturbed by epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rat | 2023 |
Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity.
Topics: Anethum graveolens; Animals; Anticonvulsants; Antioxidants; Epilepsy; Pentylenetetrazole; Picrotoxin | 2023 |
Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity.
Topics: Anethum graveolens; Animals; Anticonvulsants; Antioxidants; Epilepsy; Pentylenetetrazole; Picrotoxin | 2023 |
Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity.
Topics: Anethum graveolens; Animals; Anticonvulsants; Antioxidants; Epilepsy; Pentylenetetrazole; Picrotoxin | 2023 |
Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity.
Topics: Anethum graveolens; Animals; Anticonvulsants; Antioxidants; Epilepsy; Pentylenetetrazole; Picrotoxin | 2023 |
Clptm1, a new target in suppressing epileptic seizure by regulating GABA
Topics: Animals; Cleft Lip; Cleft Palate; Epilepsy; gamma-Aminobutyric Acid; Membrane Proteins; Pentylenetet | 2023 |
Clptm1, a new target in suppressing epileptic seizure by regulating GABA
Topics: Animals; Cleft Lip; Cleft Palate; Epilepsy; gamma-Aminobutyric Acid; Membrane Proteins; Pentylenetet | 2023 |
Clptm1, a new target in suppressing epileptic seizure by regulating GABA
Topics: Animals; Cleft Lip; Cleft Palate; Epilepsy; gamma-Aminobutyric Acid; Membrane Proteins; Pentylenetet | 2023 |
Clptm1, a new target in suppressing epileptic seizure by regulating GABA
Topics: Animals; Cleft Lip; Cleft Palate; Epilepsy; gamma-Aminobutyric Acid; Membrane Proteins; Pentylenetet | 2023 |
Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats.
Topics: Animals; Anticonvulsants; Cognitive Dysfunction; Cytokines; Diazepam; Disease Models, Animal; Epilep | 2023 |
Antibiotics modulate frequency and early generation of epileptic seizures in zebrafish.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Seizures; Zebr | 2023 |
Neuroprotection impact of biochanin A against pentylenetetrazol-kindled mice: Targeting NLRP3 inflammasome/TXNIP pathway and autophagy modulation.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Antioxidants; Autophagy; Epilepsy; Hippocampus; | 2023 |
Dietary Zinc Differentially Regulates the Effects of the GPR39 Receptor Agonist, TC-G 1008, in the Maximal Electroshock Seizure Test and Pentylenetetrazole-Kindling Model of Epilepsy.
Topics: Animals; Electroshock; Epilepsy; Mice; Pentylenetetrazole; Receptors, G-Protein-Coupled; Seizures; Z | 2023 |
The Effect of Adenosine Signaling on Memory Impairment Induced by Pentylenetetrazole in Zebrafish.
Topics: Adenosine; Animals; Dipyridamole; Epilepsy; Pentylenetetrazole; Quality of Life; Seizures; Valproic | 2023 |
Inflammation as a target for the treatment of fever-associated epilepsy in zebrafish larvae.
Topics: Animals; Disease Models, Animal; Epilepsy; Fever; Humans; Inflammation; Interleukin-1beta; Interleuk | 2023 |
Exploring the mechanism of Chaihujia Longgu Muli decoction in the treatment of epilepsy in rats based on the RhoA/ROCK signaling pathway.
Topics: Animals; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; rho-Associated K | 2023 |
Immunosuppressant Tacrolimus Treatment Delays Acute Seizure Occurrence, Reduces Elevated Oxidative Stress, and Reverses PGF2α Burst in the Brain of PTZ-Treated Rats.
Topics: Animals; Anticonvulsants; Brain; Dinoprost; Disease Models, Animal; Epilepsy; Humans; Immunosuppress | 2023 |
Tiagabine suppresses pentylenetetrazole-induced seizures in mice and improves behavioral and cognitive parameters by modulating BDNF/TrkB expression and neuroinflammatory markers.
Topics: Animals; Anticonvulsants; Brain-Derived Neurotrophic Factor; Cognition; Epilepsy; Kindling, Neurolog | 2023 |
Comprehensive characterization of amino acids and water-soluble vitamins in a pentylenetetrazole-induced seizures rat model.
Topics: Amino Acids; Animals; Epilepsy; Pentylenetetrazole; Rats; Seizures; Vitamins; Water | 2023 |
Neuroprotective effects of Royal Jelly (RJ) against pentylenetetrazole (PTZ)-induced seizures in rats by targeting inflammation and oxidative stress.
Topics: Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Epilepsy; Inflammation; Male; Neurop | 2023 |
The Potential Mechanism of Cannabidiol (CBD) Treatment of Epilepsy in Pentetrazol (PTZ) Kindling Mice Uncovered by Multi-Omics Analysis.
Topics: Animals; Anticonvulsants; Cannabidiol; Epilepsy; Mice; Multiomics; Pentylenetetrazole; Seizures | 2023 |
Efficacy and mechanisms of Dingxian pill combined with valproic acid on pentylenetetrazol-induced chronic epilepsy in rats.
Topics: Animals; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Seizures; Valproic Acid | 2023 |
Medial prefrontal cortex oxytocin mitigates epilepsy and cognitive impairments induced by traumatic brain injury through reducing neuroinflammation in mice.
Topics: Animals; Anticonvulsants; Brain Injuries, Traumatic; Cognitive Dysfunction; Disease Models, Animal; | 2023 |
Silencing of dentate gyrus inhibits mossy fiber sprouting and prevents epileptogenesis through NDR2 kinase in pentylenetetrazole kindling rat model of TLE.
Topics: Animals; Dentate Gyrus; Epilepsy; GPI-Linked Proteins; Hippocampus; Kindling, Neurologic; Membrane P | 2023 |
Implications of BCRP modulation on PTZ-induced seizures in mice: Role of ko143 and metformin as adjuvants to lamotrigine.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; Epilepsy; Lamotri | 2023 |
Tetramethylpyrazine contributes to the neuroprotection in a rodent epileptic model of pentylenetetrazole-induced kindling.
Topics: Animals; Epilepsy; Hippocampus; Kindling, Neurologic; Neuroinflammatory Diseases; Neuroprotection; P | 2023 |
The electrophysiological and behavioral evaluation of the peptide hemopressin and cannabinoid CB1 receptor agonist and antagonist in pentylenetetrazol model of epilepsy in rats.
Topics: Animals; Anticonvulsants; Cannabinoid Receptor Agonists; Cannabinoids; Dose-Response Relationship, D | 2023 |
Antiepileptic Properties of Scyllo-Inositol on Pentylenetetrazol-Induced Seizures.
Topics: Animals; Anticonvulsants; Epilepsy; Larva; Pentylenetetrazole; Seizures; Zebrafish | 2023 |
N-acetyl cysteine: A new look at its effect on PTZ-induced convulsions.
Topics: Acetylcysteine; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy; | 2023 |
Anticonvulsant Profile of Selected Medium-Chain Fatty Acids (MCFAs) Co-Administered with Metformin in Mice in Acute and Chronic Treatment.
Topics: AMP-Activated Protein Kinases; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relat | 2023 |
TC-G 1008 facilitates epileptogenesis by acting selectively at the GPR39 receptor but non-selectively activates CREB in the hippocampus of pentylenetetrazole-kindled mice.
Topics: Animals; Brain-Derived Neurotrophic Factor; Epilepsy; Hippocampus; Mice; Mice, Knockout; Pentylenete | 2023 |
Kalirin is involved in epileptogenesis by modulating the activity of the Rac1 signaling pathway.
Topics: Animals; CA1 Region, Hippocampal; Epilepsy; Guanine Nucleotide Exchange Factors; Neurons; Pentylenet | 2023 |
Ceftriaxone and selenium mitigate seizures and neuronal injury in pentylenetetrazole-kindled rats: Oxidative stress and inflammatory pathway.
Topics: Animals; Anticonvulsants; Antioxidants; Ceftriaxone; Epilepsy; Glutamates; Neurotransmitter Agents; | 2023 |
Supplementation of n-3 PUFAs in Adulthood Attenuated Susceptibility to Pentylenetetrazol Induced Epilepsy in Mice Fed with n-3 PUFAs Deficient Diet in Early Life.
Topics: Animals; Diet; Dietary Supplements; Docosahexaenoic Acids; Epilepsy; Fatty Acids, Omega-3; Female; M | 2023 |
Ameliorative effects of Albizia adianthifolia aqueous extract against pentylenetetrazole-induced epilepsy and associated memory loss in mice: Role of GABAergic, antioxidant defense and anti-inflammatory systems.
Topics: Albizzia; Amnesia; Animals; Anti-Inflammatory Agents; Anticonvulsants; Antioxidants; Epilepsy; gamma | 2023 |
Anticonvulsant potential of Grewia tiliaefolia in pentylenetetrazole induced epilepsy: insights from in vivo and in silico studies.
Topics: Animals; Anticonvulsants; Antioxidants; Chloroform; Epilepsy; Gallic Acid; gamma-Aminobutyric Acid; | 2023 |
The Aqueous Lyophilisate of Alchemilla Kiwuensis Engl. (Rosaceae) Displays Antiepileptogenic and Antiepileptic Effects on PTZ-induced Kindling in rats: Evidence of Modulation of Glutamatergic and GABAergic Pathways Coupled to Antioxidant Properties.
Topics: Alchemilla; Animals; Anticonvulsants; Antioxidants; Catalase; Epilepsy; Female; gamma-Aminobutyric A | 2023 |
Effects of probiotics on GABA/glutamate and oxidative stress in PTZ- induced acute seizure model in rats.
Topics: Animals; Anticonvulsants; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Male; Oxidative Stress; | 2023 |
A comparative study to optimize experimental conditions of pentylenetetrazol and pilocarpine-induced epilepsy in zebrafish larvae.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Epilepsy; Larva; Pentylenetetrazole; | 2023 |
Herb pair of Polygala tenuifolia Willd and Acorus tatarinowii Schott decoction attenuates seizures and alleviates anxiety in mice: Evidence for modulating inflammation, alleviating oxidative stress and mediating GABA pathway.
Topics: Acorus; Animals; Anticonvulsants; Anxiety; Epilepsy; gamma-Aminobutyric Acid; Inflammation; Mice; Ox | 2023 |
Seizure-induced increase in microglial cell population in the developing zebrafish brain.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Kainic Acid; Microglia; Pentylenetetrazole; Seizur | 2023 |
Effects of Gryllus bimaculatus and Oxya chinensis sinuosa extracts on brain damage via blood-brain barrier control and apoptosis in mice with pentylenetetrazol-induced epilepsy.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Brain; Brain Edema; Brain Injuries; Endothelial Cells; Epil | 2023 |
(-)-α-bisabolol exerts neuroprotective effects against pentylenetetrazole-induced seizures in rats by targeting inflammation and oxidative stress.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Inflammation; Male; Memory Disorders; Ne | 2023 |
Impact of noscapine on halting the progression of pentylenetetrazole induced kindling epilepsy in mice.
Topics: Animals; Anticonvulsants; Epilepsy; Kindling, Neurologic; Mice; Noscapine; Oxidative Stress; Pentyle | 2023 |
Effect of digoxin, sodium valproate, and celecoxib on the cerebral cyclooxygenase pathway and neuron-specific enolase under the pentylenetetrazole-induced kindling in mice.
Topics: Animals; Anticonvulsants; Celecoxib; Digoxin; Epilepsy; Mice; Neuroinflammatory Diseases; Pentylenet | 2023 |
Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish.
Topics: Acetylcarnitine; Acetylcysteine; Adult; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; | 2023 |
Can endoplasmic reticulum stress observed in the PTZ-kindling model seizures be prevented with TUDCA and 4-PBA?
Topics: Animals; Endoplasmic Reticulum Stress; Epilepsy; Kindling, Neurologic; Oxidative Stress; Pentylenete | 2023 |
Decrease of Cellular Communication Network Factor 1 (CCN1) Attenuates PTZ-Kindled Epilepsy in Mice.
Topics: Animals; bcl-2-Associated X Protein; Caspase 3; Epilepsy; Humans; Mice; Oxidative Stress; Pentylenet | 2023 |
Gut-Brain-axis: effect of basil oil on the gut microbiota and its contribution to the anticonvulsant properties.
Topics: Animals; Anti-Bacterial Agents; Anticonvulsants; Brain; Brain-Gut Axis; Epilepsy; Gastrointestinal M | 2023 |
Electrophysiological and Neurochemical Assessment of Selenium Alone or Combined with Carbamazepine in an Animal Model of Epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Electrodes; Electroencephalography; | 2020 |
N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum Antiepileptic Drug.
Topics: Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide | 2020 |
Fabrication and evaluation of novel quercetin-conjugated Fe
Topics: Animals; Astrocytes; beta-Cyclodextrins; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, Ne | 2019 |
Anticonvulsant and Neuroprotective Effects of Paeonol in Epileptic Rats.
Topics: Acetophenones; Animals; Anticonvulsants; Antioxidants; Apoptosis; Epilepsy; Hippocampus; Lipid Perox | 2019 |
Effect of Ibuprofen on Autophagy of Astrocytes During Pentylenetetrazol-Induced Epilepsy and its Significance: An Experimental Study.
Topics: Animals; Astrocytes; Autophagy; Brain; Cell Line; Cell Proliferation; Electroencephalography; Epilep | 2019 |
Physical exercise during pregnancy minimizes PTZ-induced behavioral manifestations in prenatally stressed offspring.
Topics: Animals; Behavior, Animal; Convulsants; Disease Models, Animal; Epilepsy; Female; Male; Pentylenetet | 2020 |
Neuroprotective effect of nilotinib on pentylenetetrazol-induced epilepsy in adult rat hippocampus: involvement of oxidative stress, autophagy, inflammation, and apoptosis.
Topics: Animals; Apoptosis; Autophagy; Epilepsy; Hippocampus; Inflammation; Male; Neuroprotective Agents; Ox | 2019 |
Low-dose intranasal insulin improves cognitive function and suppresses the development of epilepsy.
Topics: Administration, Intranasal; Animals; Anticonvulsants; Brain; Cognition; Epilepsy; Insulin; Kainic Ac | 2020 |
Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Colitis; Convulsants; Dextran Sul | 2019 |
Preparation and Evaluation of Carbamazepine Solid Lipid Nanoparticle for Alleviating Seizure Activity in Pentylenetetrazole-Kindled Mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Compounding; Epilepsy; Humans; | 2019 |
Evaluation of the impact of compound C11 a new anticonvulsant candidate on cognitive functions and hippocampal neurogenesis in mouse brain.
Topics: Animals; Anticonvulsants; Brain; Cognition; Epilepsy; Ethosuximide; Hippocampus; Lacosamide; Levetir | 2020 |
Evaluation of sodium valproate loaded nanoparticles in acute and chronic pentylenetetrazole induced seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Maze Learning; Oxidative Stress; Pentyle | 2019 |
An interaction study of Ocimum sanctum L. and levetiracetam in pentylenetetrazole kindling model of epilepsy.
Topics: Animals; Anticonvulsants; Avoidance Learning; Disease Models, Animal; Drug Therapy, Combination; Epi | 2020 |
Pentylenetetrazole-induced Seizure Susceptibility in the Tau58/4 Transgenic Mouse Model of Tauopathy.
Topics: Animals; Brain; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy; Mice, Inbred | 2020 |
TRPM2 ion channel is involved in the aggravation of cognitive impairment and down regulation of epilepsy threshold in pentylenetetrazole-induced kindling mice.
Topics: Animals; Apoptosis; Astrocytes; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Hippocampus | 2020 |
Prolonged febrile seizure history exacerbates seizure severity in a pentylenetetrazole rat model of epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Glial Fibrillary Acidic Protein; Hippocampus; Male; Penty | 2020 |
Exploring the ameliorative role of α7 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anticonvulsants; Corticosterone; Depression; Dose- | 2020 |
LncRNA CASC2 inhibits astrocytic activation and adenosine metabolism by regulating PTEN in pentylenetetrazol-induced epilepsy model.
Topics: Adenosine; Animals; Astrocytes; Epilepsy; Hippocampus; Male; Pentylenetetrazole; PTEN Phosphohydrola | 2020 |
Proconvulsant effect of trans-cinnamaldehyde in pentylenetetrazole-induced kindling model of epilepsy: The role of TRPA1 channels.
Topics: Acrolein; Animals; Convulsants; Dose-Response Relationship, Drug; Electrocorticography; Epilepsy; Ki | 2020 |
Rational design of ultra-small photoluminescent copper nano-dots loaded PLGA micro-vessels for targeted co-delivery of natural piperine molecules for the treatment for epilepsy.
Topics: Alkaloids; Animals; Anticonvulsants; Benzodioxoles; Cell Line; Cell Survival; Copper; Drug Delivery | 2020 |
The role of REST/NRSF, TrkB and BDNF in neurobiological mechanisms of different susceptibility to seizure in a PTZ model of epilepsy.
Topics: Animals; Brain-Derived Neurotrophic Factor; Epilepsy; Genetic Predisposition to Disease; Male; Penty | 2020 |
Long-term potentiation enhancing effect of epileptic insult in the CA1 area is dependent on prior-application of primed-burst stimulation.
Topics: Animals; CA1 Region, Hippocampal; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Antagonist | 2020 |
T-type Ca
Topics: Animals; CA1 Region, Hippocampal; Calcium Channel Blockers; Calcium Channels, T-Type; Epilepsy; Long | 2020 |
Antagonism of Histamine H3 receptors Alleviates Pentylenetetrazole-Induced Kindling and Associated Memory Deficits by Mitigating Oxidative Stress, Central Neurotransmitters, and c-Fos Protein Expression in Rats.
Topics: Animals; Epilepsy; Gene Expression Regulation; Hippocampus; Histamine H3 Antagonists; Kindling, Neur | 2020 |
Glutamatergic pathway in depressive-like behavior associated with pentylenetetrazole rat model of epilepsy with history of prolonged febrile seizures.
Topics: Amygdala; Animals; Brain-Derived Neurotrophic Factor; Depression; Epilepsy; Excitatory Amino Acid Tr | 2020 |
Effects of Diclofenac Versus Meloxicam in Pentylenetetrazol-Kindled Mice.
Topics: Animals; Anticonvulsants; Diclofenac; Epilepsy; Kindling, Neurologic; Male; Meloxicam; Mice; Pentyle | 2020 |
STK24 modulates excitatory synaptic transmission in epileptic hippocampal neurons.
Topics: Adolescent; Adult; Animals; Animals, Newborn; Cells, Cultured; Child; Epilepsy; Epilepsy, Temporal L | 2020 |
Autophagy associated with the efficacy of valproic acid in PTZ-induced epileptic rats.
Topics: Animals; Anticonvulsants; Autophagy; Convulsants; Drug Resistance; Epilepsy; Male; Pentylenetetrazol | 2020 |
Neuropolybin: A new antiseizure peptide obtained from wasp venom.
Topics: Animals; Anticonvulsants; Electroencephalography; Epilepsy; Female; Male; Mice; Pentylenetetrazole; | 2020 |
COX-2-PGE
Topics: Animals; Cognitive Dysfunction; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Epilepsy; Hi | 2020 |
Rediscovery of Rue for the treatment of epilepsy.
Topics: Animals; Anticonvulsants; Benzofurans; Brain-Derived Neurotrophic Factor; Epilepsy; Pentylenetetrazo | 2020 |
Ibuprofen Exerts Antiepileptic and Neuroprotective Effects in the Rat Model of Pentylenetetrazol-Induced Epilepsy via the COX-2/NLRP3/IL-18 Pathway.
Topics: Action Potentials; Animals; Anticonvulsants; Cyclooxygenase 2; Epilepsy; Hippocampus; Ibuprofen; Int | 2020 |
Salidroside shows anticonvulsant and neuroprotective effects by activating the Nrf2-ARE pathway in a pentylenetetrazol-kindling epileptic model.
Topics: Animals; Anticonvulsants; Carboxylic Ester Hydrolases; Epilepsy; Glucosides; Hippocampus; Kindling, | 2020 |
Acteoside Isolated from Colebrookea oppositifolia Smith Attenuates Epilepsy in Mice Via Modulation of Gamma-Aminobutyric Acid Pathways.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; GABA Antagonists; gamma-Aminob | 2020 |
Homostachydrine is a Xenobiotic Substrate of OCTN1/SLC22A4 and Potentially Sensitizes Pentylenetetrazole-Induced Seizures in Mice.
Topics: Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Cytoskeletal Proteins; Epilepsy; Ergothion | 2020 |
Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility.
Topics: Animals; Chromosome Mapping; Collaborative Cross Mice; Convulsants; Disease Models, Animal; Epilepsy | 2020 |
Synthesis of 3,4-dihydroquinolin-2(1H)-one derivatives with anticonvulsant activity and their binding to the GABA
Topics: Animals; Anticonvulsants; Drug Design; Electroshock; Epilepsy; Mice; Molecular Docking Simulation; M | 2020 |
Neuroprotective role of chrysin-loaded poly(lactic-co-glycolic acid) nanoparticle against kindling-induced epilepsy through Nrf2/ARE/HO-1 pathway.
Topics: Animals; Carboxylic Ester Hydrolases; Epilepsy; Flavonoids; Heme Oxygenase-1; Kindling, Neurologic; | 2021 |
Integrative analysis of non-targeted lipidomic data and brain structural imaging identifies phosphatidylethanolamine associated with epileptogenesis.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, Neurologic; Lactones; Lipid | 2020 |
Extraction, GC-MS Evaluation and Anti-epileptic Potential of Seeds Ethanolic Extract of Putranjiva roxburghii Wall.
Topics: Anticonvulsants; Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; Pentylenetetrazole; Plant E | 2020 |
Cognition and memory impairment attenuation via reduction of oxidative stress in acute and chronic mice models of epilepsy using antiepileptogenic Nux vomica.
Topics: Acute Disease; Animals; Anticonvulsants; Antioxidants; Behavior, Animal; Brain; Chronic Disease; Cog | 2021 |
Computational Study and Synthesis of a New Class of Anticonvulsants with 6 Hz Psychomotor Seizure Test Activity: 2-(1,3-benzodioxol-5-yloxy)- N'-[substituted]-acetohydrazides.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Epilepsy; Humans; Hydrazin | 2021 |
Environmental enrichment alters neurobehavioral development following maternal immune activation in mice offspring with epilepsy.
Topics: Animals; Anxiety; Behavior, Animal; Cognitive Dysfunction; Convulsants; Disease Models, Animal; Dise | 2021 |
The effects of salmon calcitonin on epileptic seizures, epileptogenesis, and postseizure hippocampal neuronal damage in pentylenetetrazole-induced epilepsy model in rats.
Topics: Animals; Calcitonin; Epilepsy; Hippocampus; Kindling, Neurologic; Pentylenetetrazole; Rats; Seizures | 2020 |
Stress increases susceptibility to pentylenetetrazole-induced seizures in adult zebrafish.
Topics: Animals; Anxiety; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Seizures; Zebrafish | 2021 |
iTRAQ-based proteomic analysis of the hippocampus of pentylenetetrazole-kindled epileptic rats.
Topics: Animals; Chromatography, Liquid; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Pentylenetetrazo | 2021 |
Butyrate alleviates PTZ-induced mitochondrial dysfunction, oxidative stress and neuron apoptosis in mice via Keap1/Nrf2/HO-1 pathway.
Topics: Animals; Animals, Outbred Strains; Apoptosis; Butyrates; Epilepsy; Heme Oxygenase-1; Hippocampus; Ke | 2021 |
Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats.
Topics: Adjuvants, Pharmaceutic; Animals; Anticonvulsants; Behavior, Animal; Centella; Cognitive Dysfunction | 2021 |
Pharmacological and toxicological effects of Ruta chalepensis L. on experimentally induced seizures and electroencephalographic spectral power in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Electroencephalography; Electroshock; Epilepsy; Male; Me | 2021 |
FTY720 administration following hypoxia-induced neonatal seizure reverse cognitive impairments and severity of seizures in male and female adult rats: The role of inflammation.
Topics: Aging; Animals; Animals, Newborn; Cognitive Dysfunction; Epilepsy; Female; Fingolimod Hydrochloride; | 2021 |
Mast cell activation ameliorates pentylenetetrazole-induced seizures in rats: The potential role for serotonin.
Topics: Animals; Anticonvulsants; Cromolyn Sodium; Epilepsy; Male; Mast Cells; Pentylenetetrazole; Rats; Rat | 2022 |
In vivo anticonvulsant activity of 2-propanone-1,3,5,5-trimethyl-2-cyclohexen-1-ylidine in pilocarpine and strychnine induced-seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Male; Mice; Pentylenetetrazole; Pilocarp | 2020 |
Gene Expression Analysis Identifies Cholesterol Metabolism Dysregulation in Hippocampus of Phenytoin-Resistant Pentylenetetrazol-Kindled Epileptic Mice.
Topics: Animals; Anticonvulsants; Cholesterol; Epilepsy; Gene Expression; Hippocampus; Humans; Kindling, Neu | 2021 |
Postictal Death Is Associated with Tonic Phase Apnea in a Mouse Model of Sudden Unexpected Death in Epilepsy.
Topics: Animals; Apnea; Convulsants; Diaphragm; Electroencephalography; Electromyography; Epilepsy; Female; | 2021 |
Anticonvulsant effects of the aqueous and methanol extracts from the stem bark of Psychotria camptopus Verdc. (Rubiacaea) in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Epilepsy; Methanol; Mi | 2021 |
Pentylenetetrazol-induced seizures in adult rats are associated with plastic changes to the dendritic spines on hippocampal CA1 pyramidal neurons.
Topics: Animals; Brain-Derived Neurotrophic Factor; CA1 Region, Hippocampal; Dendritic Spines; Disease Model | 2021 |
The modulator action of thiamine against pentylenetetrazole-induced seizures, apoptosis, nitric oxide, and oxidative stress in rats and SH-SY5Y neuronal cell line.
Topics: Animals; Anticonvulsants; Antioxidants; Apoptosis; Brain; Caspase 3; Cell Line; Disease Models, Anim | 2021 |
Pharmacological Activity of Pyrazole Derivatives as an Anticonvulsant for Benefit against Epilepsy.
Topics: Animals; Anticonvulsants; Child; Disease Models, Animal; Epilepsy; Humans; Mice; Pentylenetetrazole; | 2021 |
Evaluation of cytokines expression in the phytoflavonoids treated epileptic rats: An in vivo study.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Brain; Chronic Disease; Cytokines; Disease Model | 2020 |
An optimized method for adult zebrafish brain-tissue dissociation that allows access mitochondrial function under healthy and epileptic conditions.
Topics: Animals; Brain; Cell Respiration; Disease Models, Animal; Energy Metabolism; Epilepsy; Female; Histo | 2021 |
Exercise Improved the Anti-Epileptic Effect of Carbamazepine through GABA Enhancement in Epileptic Rats.
Topics: Animals; Anticonvulsants; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Carbamazepine; Epilepsy; | 2021 |
Vagus Nerve Electroneurogram-Based Detection of Acute Pentylenetetrazol Induced Seizures in Rats.
Topics: Animals; Epilepsy; Pentylenetetrazole; Rats; Seizures; Treatment Outcome; Vagus Nerve; Vagus Nerve S | 2021 |
Rhein attenuates PTZ‑induced epilepsy and exerts neuroprotective activity via inhibition of the TLR4-NFκB signaling pathway.
Topics: Animals; Anthraquinones; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy; | 2021 |
A zebrafish-centric approach to antiepileptic drug development.
Topics: Animals; Anticonvulsants; Epilepsy; Pentylenetetrazole; Seizures; Zebrafish | 2021 |
Inhibition of Death-associated Protein Kinase 1 protects against Epileptic Seizures in mice.
Topics: Animals; Death-Associated Protein Kinases; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, | 2021 |
Protective effects of long-term probiotic mixture supplementation against pentylenetetrazole-induced seizures, inflammation and oxidative stress in rats.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Convulsants; Cytokines; Disease Models, Animal; Epile | 2021 |
Carveol Attenuates Seizure Severity and Neuroinflammation in Pentylenetetrazole-Kindled Epileptic Rats by Regulating the
Topics: Animals; Antioxidants; Cyclohexane Monoterpenes; Epilepsy; Kindling, Neurologic; Lipid Peroxidation; | 2021 |
Ameliorative potential of Colebrookea oppositifolia methanolic root extract against experimental models of epilepsy: Possible role of GABA mediated mechanism.
Topics: Animals; Anticonvulsants; Brain; Electroshock; Epilepsy; gamma-Aminobutyric Acid; Lamiaceae; Medicin | 2017 |
[The 2-chloride adenosine alleviates the damage of brain tissues in pentylenetetrazole-kindled epileptic mice by regulating P-glycoprotein expression].
Topics: Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Epilepsy; Hippoc | 2017 |
P38 MAPK pathway mediates cognitive damage in pentylenetetrazole-induced epilepsy via apoptosis cascade.
Topics: Analysis of Variance; Animals; Apoptosis; Caspase 3; Cognition Disorders; Convulsants; Disease Model | 2017 |
DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy.
Topics: Action Potentials; Animals; Anthracenes; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; D | 2017 |
Adenosine A1 Receptors Play an Important Protective Role Against Cognitive Impairment and Long-Term Potentiation Inhibition in a Pentylenetetrazol Mouse Model of Epilepsy.
Topics: Animals; Caspase 3; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, | 2018 |
The PTZ kindling mouse model of epilepsy exhibits exploratory drive deficits and aberrant activity amongst VTA dopamine neurons in both familiar and novel space.
Topics: Animals; Convulsants; Disease Models, Animal; Dopaminergic Neurons; Epilepsy; Hippocampus; Kindling, | 2017 |
Automated analysis of brain activity for seizure detection in zebrafish models of epilepsy.
Topics: Animals; Automation, Laboratory; Brain; Disease Models, Animal; Electroencephalography; Epilepsy; La | 2017 |
Effects of agomelatine on pentylenetetrazole-induced kindling, kindling-associated oxidative stress, and behavioral despair in mice and modulation of its actions by luzindole and 1-(m-chlorophenyl) piperazine.
Topics: Acetamides; Animals; Anticonvulsants; Antioxidants; Depression; Drug Therapy, Combination; Epilepsy; | 2017 |
Agmatine for combined treatment of epilepsy, depression and cognitive impairment in chronic epileptic animals.
Topics: Agmatine; Animals; Cognitive Dysfunction; Depression; Epilepsy; Male; Mice; Pentylenetetrazole | 2017 |
Intra-hippocampal microinjection of oxytocin produced antiepileptic effect on the pentylenetetrazol-induced epilepsy in rats.
Topics: Animals; Anticonvulsants; Diazepam; Epilepsy; Flumazenil; Hippocampus; Male; Microinjections; Oxytoc | 2017 |
Ferulic Acid Supplementation for Management of Depression in Epilepsy.
Topics: Animals; Anticonvulsants; Brain; Coumaric Acids; Depression; Depressive Disorder; Disease Models, An | 2017 |
Toxoplasmosis accelerates acquisition of epilepsy in rats undergoing chemical kindling.
Topics: Animals; Disease Models, Animal; Epilepsy; Kaplan-Meier Estimate; Kindling, Neurologic; Male; Pentyl | 2017 |
Metabolic correction by pyruvate halts acquired epilepsy in multiple rodent models.
Topics: Alzheimer Disease; Animals; Anticonvulsants; Brain; Brain Waves; Drug Evaluation, Preclinical; Epile | 2017 |
Intranasal nerve growth factor attenuating the seizure onset via p75R/Caspase pathway in the experimental epilepsy.
Topics: Administration, Intranasal; Animals; Anticonvulsants; Brain; Caspase 3; Epilepsy; Male; Nerve Growth | 2017 |
Impairment of GABAergic system contributes to epileptogenesis in glutaric acidemia type I.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Blotting, Western; Brain; Brain Diseases, Metabolic; | 2017 |
Anticonvulsant effects of thiamine on pentylenetetrazole-induced seizure in mice.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Epilep | 2019 |
Curcumin-loaded chitosan-alginate-STPP nanoparticles ameliorate memory deficits and reduce glial activation in pentylenetetrazol-induced kindling model of epilepsy.
Topics: Animals; Anticonvulsants; Brain; Chronic Disease; Curcumin; Disease Models, Animal; Dose-Response Re | 2017 |
Trigeminal nerve stimulation induces Fos immunoreactivity in selected brain regions, increases hippocampal cell proliferation and reduces seizure severity in rats.
Topics: Amygdala; Animals; Cell Proliferation; Epilepsy; Hippocampus; Male; Pentylenetetrazole; Proto-Oncoge | 2017 |
Vitamin D enhances antiepileptic and cognitive effects of lamotrigine in pentylenetetrazole-kindled rats.
Topics: Animals; Anticonvulsants; Antioxidants; Cholecalciferol; Chronic Disease; Cognition; Disease Models, | 2017 |
Pharmacokinetic and pharmacodynamic interaction of hydroalcoholic extract of Ocimum sanctum with valproate.
Topics: Animals; Anticonvulsants; Antioxidants; Avoidance Learning; Cognition; Disease Models, Animal; Drug | 2017 |
Piperine-loaded chitosan-STPP nanoparticles reduce neuronal loss and astrocytes activation in chemical kindling model of epilepsy.
Topics: Alkaloids; Animals; Astrocytes; Benzodioxoles; Chitosan; Disease Models, Animal; Epilepsy; Humans; H | 2018 |
SSa ameliorates the Glu uptaking capacity of astrocytes in epilepsy via AP-1/miR-155/GLAST.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Transporter 1; gamma-Am | 2017 |
Quinine and carbenoxolone enhance the anticonvulsant activity of some classical antiepileptic drugs.
Topics: Animals; Anticonvulsants; Carbenoxolone; Convulsants; Disease Models, Animal; Dose-Response Relation | 2018 |
Sitagliptin enhances the neuroprotective effect of pregabalin against pentylenetetrazole-induced acute epileptogenesis in mice: Implication of oxidative, inflammatory, apoptotic and autophagy pathways.
Topics: Animals; Antioxidants; Autophagy; Epilepsy; Hippocampus; Kindling, Neurologic; Lipid Peroxidation; M | 2018 |
Ketogenic diet attenuates neuronal injury via autophagy and mitochondrial pathways in pentylenetetrazol-kindled seizures.
Topics: Adenine; Animals; Apoptosis; Autophagy; Caspase 3; Cytochromes c; Diet, Ketogenic; Epilepsy; Hippoca | 2018 |
Kappa opioid receptors regulate hippocampal synaptic homeostasis and epileptogenesis.
Topics: Animals; Cells, Cultured; Central Nervous System Stimulants; Convulsants; Disease Models, Animal; Di | 2018 |
Immature Status Epilepticus: In Vitro Models Reveal Differences in Cholinergic Control and HFO Properties of Adult CA3 Interictal Discharges in Temporal vs Septal Hippocampus.
Topics: Acetylcholinesterase; Animals; CA3 Region, Hippocampal; Disease Models, Animal; Epilepsy; Pentylenet | 2018 |
Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole-induced epilepsy through the induction of Homer1a.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Convulsants; Epilepsy; Homeostasis; Homer Sca | 2018 |
Anticonvulsant effects of acetaminophen in mice: Comparison with the effects of nonsteroidal anti-inflammatory drugs.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Cyclooxygenase Inh | 2018 |
Interactions between GHRH and GABAARs in the brains of patients with epilepsy and in animal models of epilepsy.
Topics: Adult; Animals; Cerebral Cortex; Disease Models, Animal; Epilepsy; Female; Growth Hormone-Releasing | 2017 |
Ginsenoside Rb1 Protects the Brain from Damage Induced by Epileptic Seizure via Nrf2/ARE Signaling.
Topics: Animals; Antioxidant Response Elements; Brain Injuries; Down-Regulation; Epilepsy; Ginsenosides; Glu | 2018 |
Embryonic exposure to ethanol increases the susceptibility of larval zebrafish to chemically induced seizures.
Topics: Animals; Convulsants; Disease Models, Animal; Embryo, Nonmammalian; Epilepsy; Ethanol; Larva; Pentyl | 2018 |
RNA Polymerase 1 Is Transiently Regulated by Seizures and Plays a Role in a Pharmacological Kindling Model of Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Mice, Inbred C57 | 2018 |
Discovery of novel Methylsulfonyl phenyl derivatives as potent human Cyclooxygenase-2 inhibitors with effective anticonvulsant action: Design, synthesis, in-silico, in-vitro and in-vivo evaluation.
Topics: Animals; Anticonvulsants; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Design; Epilepsy; Huma | 2018 |
Corilagin Reduces the Frequency of Seizures and Improves Cognitive Function in a Rat Model of Chronic Epilepsy.
Topics: Animals; Biomarkers; Brain; Carbonic Anhydrases; Catalase; Cell Count; Chronic Disease; Cognition; C | 2018 |
Satb2 ablation decreases PTZ-induced seizure susceptibility and pyramidal neuronal excitability.
Topics: Animals; Epilepsy; Hippocampus; Matrix Attachment Region Binding Proteins; Mice, Transgenic; Pentyle | 2018 |
Pharmacological Evaluation of Novel Flavone from Morus alba in Pentylenetetrazole-Induced Kindling and Oxidative Stress.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epi | 2018 |
Sinomenine exerts anticonvulsant profile and neuroprotective activity in pentylenetetrazole kindled rats: involvement of inhibition of NLRP1 inflammasome.
Topics: Analysis of Variance; Animals; Anticonvulsants; CARD Signaling Adaptor Proteins; Caspase 1; Convulsa | 2018 |
Neuroprotective mechanisms of sildenafil and selenium in PTZ-kindling model: Implications in epilepsy.
Topics: Animals; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Mice; Neurons; Neuroprotective Agents; O | 2018 |
[Establish and use of an epilepsy model in larval zebrafish].
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy; Larva; Nerve Tissue Proteins; Pen | 2016 |
The anti-epileptogenic and cognition enhancing effect of novel 1-[4-(4-benzo [1, 3] dioxol-5-ylmethyl-piperazin-1-yl)-phenyl]-3-phenyl-urea (BPPU) in pentylenetetrazole induced chronic rat model of epilepsy.
Topics: Animals; Cerebral Cortex; Chronic Disease; Cognition; Cognitive Dysfunction; Disease Models, Animal; | 2018 |
Overexpression of miRNA-137 in the brain suppresses seizure activity and neuronal excitability: A new potential therapeutic strategy for epilepsy.
Topics: Adolescent; Adult; Animals; Brain; Disease Models, Animal; Epilepsy; Female; Humans; Inhibitory Post | 2018 |
Experimental Substantiation of Inhalation Administration of Pathogenic Therapy of Toxic Convulsive Disorder for Correction of External Respiration Disorders.
Topics: Administration, Inhalation; Albuterol; Animals; Atropine; Bronchodilator Agents; Convulsants; Diazep | 2018 |
UCH-L1 inhibition aggravates mossy fiber sprouting in the pentylenetetrazole kindling model.
Topics: Animals; Epilepsy; Kindling, Neurologic; Mossy Fibers, Hippocampal; Pentylenetetrazole; Phosphorylat | 2018 |
Synthesis and Anticonvulsant Activity of 3-(alkylamino, alkoxy)-1,3,4,5- Tetrahydro-2H-benzo [b] azepine-2-one Derivatives.
Topics: Alcohols; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Mice; Pentylenet | 2018 |
[PATHOLOGICAL CHANGES DEVELOPMENT IN THE HEART WITH UNDERLYING CONVULSIVE SYNDROME MODEL OF VARIOUS ETIOLOGIES.]
Topics: Adenosine Triphosphate; Animals; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; L-Lact | 2016 |
Golgi-specific DHHC type zinc finger protein is decreased in neurons of intractable epilepsy patients and pentylenetetrazole-kindled rats.
Topics: Adolescent; Adult; Animals; Astrocytes; Carrier Proteins; Child; Drug Resistant Epilepsy; Epilepsy; | 2018 |
[Intervention Study of Mineral Chinese Medicine Chloriti Lapis in PTZ-kindled Epileptic Rat].
Topics: Animals; Antioxidants; Brain; Epilepsy; Hippocampus; Minerals; Pentylenetetrazole; Rats; Sodium-Pota | 2016 |
Evaluation of ghrelin, nesfatin-1 and irisin levels of serum and brain after acute or chronic pentylenetetrazole administrations in rats using sodium valproate.
Topics: Animals; Anticonvulsants; Biomarkers; Brain; Calcium-Binding Proteins; Disease Models, Animal; DNA-B | 2018 |
Upregulation of klotho and erythropoietin contributes to the neuroprotection induced by curcumin-loaded nanoparticles in experimental model of chronic epilepsy.
Topics: Animals; Chronic Disease; Curcumin; Disease Models, Animal; DNA-Binding Proteins; Drug Carriers; Epi | 2018 |
The effect of high-fat diet on seizure threshold in rats: Role of oxidative stress.
Topics: Animals; Cerebellum; Cerebral Cortex; Diet, High-Fat; Disease Models, Animal; Epilepsy; Hippocampus; | 2018 |
Anticonvulsant effect of anacardic acid in murine models: Putative role of GABAergic and antioxidant mechanisms.
Topics: Anacardic Acids; Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Electroshock; Epile | 2018 |
Modulation of P2X Purinoceptor 3 (P2X3) in Pentylenetetrazole-Induced Kindling Epilepsy in Rats.
Topics: Animals; Benzenesulfonates; Brain; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, Neurolog | 2018 |
Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Encephalitis; Epilepsy; G | 2018 |
Anticonvulsant effects after grafting of rat, porcine, and human mesencephalic neural progenitor cells into the rat subthalamic nucleus.
Topics: Animals; Convulsants; Disease Models, Animal; Embryo, Mammalian; Epilepsy; Fetus; gamma-Aminobutyric | 2018 |
KA-11, a Novel Pyrrolidine-2,5-dione Derived Broad-Spectrum Anticonvulsant: Its Antiepileptogenic, Antinociceptive Properties and in Vitro Characterization.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Male; Mice; Molecular Struct | 2019 |
Effects of metformin on apoptosis and α-synuclein in a rat model of pentylenetetrazole-induced epilepsy.
Topics: alpha-Synuclein; Animals; Apoptosis; Convulsants; Epilepsy; Male; Metformin; Pentylenetetrazole; Rat | 2019 |
Deep brain stimulation probing performance is enhanced by pairing stimulus with epileptic seizure.
Topics: Amygdala; Animals; Convulsants; Deep Brain Stimulation; Disease Models, Animal; Electroencephalograp | 2018 |
NLRP3 Inflammasome Activation Leads to Epileptic Neuronal Apoptosis.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Convulsants; Disease Models, Anima | 2018 |
Effect of dimethyl fumarate on neuroinflammation and apoptosis in pentylenetetrazol kindling model in rats.
Topics: Animals; Apoptosis; Dimethyl Fumarate; Disease Models, Animal; Epilepsy; Hippocampus; Inflammation; | 2019 |
Arbutin attenuates cognitive impairment and inflammatory response in pentylenetetrazol-induced kindling model of epilepsy.
Topics: Animals; Antigens, Nuclear; Arbutin; Astrocytes; Cognitive Dysfunction; Cytokines; Disease Models, A | 2019 |
Edaravone acts as a potential therapeutic drug against pentylenetetrazole-induced epilepsy in male albino rats by downregulating cyclooxygenase-II.
Topics: Animals; Antioxidants; Brain; Convulsants; Cyclooxygenase 2; Disease Models, Animal; Down-Regulation | 2019 |
Levodropropizine suppresses seizure activity in rats with pentylenetetrazol-induced epilepsy.
Topics: Analysis of Variance; Animals; Antitussive Agents; Convulsants; Disease Models, Animal; Electroencep | 2019 |
Expression of cardiac inwardly rectifying potassium channels in pentylenetetrazole kindling model of epilepsy in rats.
Topics: Animals; Autonomic Nervous System; Blood Pressure; Disease Models, Animal; Electrocardiography; Epil | 2018 |
Effects of Leontice leontopetalum and Bongardia chrysogonum on oxidative stress and neuroprotection in PTZ kindling epilepsy in rats.
Topics: Animals; Berberidaceae; Cyclin B1; Epilepsy; Glutathione Peroxidase; Hippocampus; Kindling, Neurolog | 2018 |
Exploratory Cortex Metabolic Profiling Revealed the Sedative Effect of Amber in Pentylenetetrazole-Induced Epilepsy-Like Mice.
Topics: Amber; Animals; Behavior, Animal; Cerebral Cortex; Chromatography, Liquid; Disease Models, Animal; E | 2019 |
Expression of nuclear factor-erythroid 2-related factor 2 in rat brain following the administration of kainic acid and pentylenetetrazole.
Topics: Animals; Brain; Convulsants; Epilepsy; Kainic Acid; Male; NF-E2-Related Factor 2; Oxidative Stress; | 2019 |
Early α-linolenic acid exposure to embryo reduces pentylenetetrazol-induced seizures in zebrafish larva.
Topics: alpha-Linolenic Acid; Animals; Behavior, Animal; Convulsants; Dietary Supplements; Disease Models, A | 2019 |
Evaluation of anticonvulsant and antiepileptogenic activity of Euphorbia nivulia in PTZ-induced kindling model of epilepsy in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy; Euphorbia; | 2019 |
The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Drug Resistance; Epilepsy; Kindling, | 2019 |
Excavating precursors from the traditional Chinese herb Polygala tenuifolia and Gastrodia elata: Synthesis, anticonvulsant activity evaluation of 3,4,5-trimethoxycinnamic acid (TMCA) ester derivatives.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Binding Sites; Cinnamates; Drug Design; Epil | 2019 |
Target identification, screening and in vivo evaluation of pyrrolone-fused benzosuberene compounds against human epilepsy using Zebrafish model of pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Class I Phosphatidylinositol 3-Kinases; Coumarins; Disease Models, Animal; | 2019 |
Pentylenetetrazol-induced epileptiform activity affects basal synaptic transmission and short-term plasticity in monosynaptic connections.
Topics: Animals; Cell Culture Techniques; Coculture Techniques; Epilepsy; Helix, Snails; Humans; Neuronal Pl | 2013 |
Increased susceptibility to pentetrazol-induced seizures in developing rats after cortical photothrombotic ischemic stroke at P7.
Topics: Animals; Brain; Brain Ischemia; Convulsants; Disease Models, Animal; Electroencephalography; Epileps | 2013 |
MRI biomarkers for post-traumatic epileptogenesis.
Topics: Animals; Area Under Curve; Biomarkers; Brain Injuries; Brain Mapping; Convulsants; Diffusion Tensor | 2013 |
Targeted mutation of the gene encoding prion protein in zebrafish reveals a conserved role in neuron excitability.
Topics: Age Factors; Animals; Animals, Genetically Modified; Disease Models, Animal; Epilepsy; Gene Expressi | 2013 |
A unified approach for detection of induced epileptic seizures in rats using ECoG signals.
Topics: Algorithms; Animals; Brain; Convulsants; Databases, Factual; Disease Models, Animal; Disease Progres | 2013 |
BDNF-TrkB signaling pathway is involved in pentylenetetrazole-evoked progression of epileptiform activity in hippocampal neurons in anesthetized rats.
Topics: Administration, Intravenous; Anesthesia, General; Animals; Brain-Derived Neurotrophic Factor; CA1 Re | 2013 |
Glatiramer acetate, an anti-demyelination drug, reduced rats' epileptic seizures induced by pentylenetetrazol via protection of myelin sheath.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Epilepsy; Glatiramer Acetate; Hippocampus; Male; Myelin B | 2013 |
Changes in the Egr1 and Arc expression in brain structures of pentylenetetrazole-kindled rats.
Topics: Animals; Brain; Brain Mapping; Cytoskeletal Proteins; Disease Models, Animal; Early Growth Response | 2013 |
[Anticonvulsant effect of dicholine succinate on primary generalized epilepsy model in mice].
Topics: Animals; Anticonvulsants; Choline; Convulsants; Disease Models, Animal; Dose-Response Relationship, | 2013 |
Lamotrigine positively affects the development of psychiatric comorbidity in epileptic animals, while psychiatric comorbidity aggravates seizures.
Topics: Animals; Anticonvulsants; Comorbidity; Disease Models, Animal; Epilepsy; Exploratory Behavior; Food | 2013 |
Hyperexcitability and epileptic seizures in a model of frontotemporal dementia.
Topics: Animals; Brain; Calcium-Binding Proteins; Convulsants; Disease Models, Animal; DNA-Binding Proteins; | 2013 |
Psychoneurochemical investigations to reveal neurobiology of memory deficit in epilepsy.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Chromatography, High Pressure Liquid; Convul | 2013 |
Evaluation of anti-epileptic property of Marsilea quadrifolia Linn. in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; Male; Marsileaceae; Pentylenet | 2013 |
Epilepsy in kcnj10 morphant zebrafish assessed with a novel method for long-term EEG recordings.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Disease Models, Animal; Electroencephalograp | 2013 |
Anticonvulsant activity of Aloe vera leaf extract in acute and chronic models of epilepsy in mice.
Topics: Aloe; Animals; Antioxidants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electr | 2014 |
Effects of single-dose neuropeptide Y on levels of hippocampal BDNF, MDA, GSH, and NO in a rat model of pentylenetetrazole-induced epileptic seizure.
Topics: Animals; Brain-Derived Neurotrophic Factor; Convulsants; Disease Models, Animal; Epilepsy; Glutathio | 2013 |
Novel Vitamin K analogs suppress seizures in zebrafish and mouse models of epilepsy.
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Cell Line; Disease Models, Animal; Dose-Response R | 2014 |
Neuroprotective effects of heptapeptide mystixin.
Topics: Action Potentials; Animals; Anticonvulsants; Drug Evaluation, Preclinical; Epilepsy; GABA Agents; In | 2013 |
Electroencephalographic characterization of pentylenetetrazole kindling in rats and modulation of epileptiform discharges by nitric oxide.
Topics: Animals; Electroencephalography; Electromyography; Epilepsy; Fourier Analysis; Kindling, Neurologic; | 2014 |
[Comparison of seizure induced by different drugs in ICR Mice].
Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Mice; Mice, Inbred ICR; Pentylenetetra | 2013 |
Modulation of c-Fos and BDNF protein expression in pentylenetetrazole-kindled mice following the treatment with novel antiepileptic compound HHL-6.
Topics: Animals; Anticonvulsants; Brain; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Epilepsy | 2014 |
Parvalbumin immunoreactivity and expression of GABAA receptor subunits in the thalamus after experimental TBI.
Topics: Animals; Brain Injuries; Disease Models, Animal; Electroencephalography; Epilepsy; Functional Latera | 2014 |
A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.
Topics: Action Potentials; Animals; Animals, Newborn; Brain; Bumetanide; Convulsants; Disease Models, Animal | 2014 |
Expression of SOCSs and TLRs in the hippocampus of pentylenetetrazole kindling model.
Topics: Animals; Disease Models, Animal; Down-Regulation; Epilepsy; Hippocampus; Interleukin-1beta; Kindling | 2014 |
Characterization of a lamotrigine-resistant kindled model of epilepsy in mice: evaluation of drug resistance mechanisms.
Topics: Animals; Anticonvulsants; Calcium Channels; Carbamazepine; Disease Models, Animal; Drug Resistance; | 2014 |
Anticonvulsive effect of nonimidazole histamine H3 receptor antagonists.
Topics: Algorithms; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationshi | 2014 |
Design, synthesis and biological evaluation of novel thiosemicarbazide analogues as potent anticonvulsant agents.
Topics: Animals; Anticonvulsants; Drug Design; Electroshock; Epilepsy; Male; Mice; Molecular Structure; Moto | 2014 |
Identification of marine neuroactive molecules in behaviour-based screens in the larval zebrafish.
Topics: Animals; Anticonvulsants; Behavior, Animal; Biological Products; Disease Models, Animal; Epilepsy; F | 2014 |
Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models.
Topics: Acute Disease; Amino Acids, Dicarboxylic; Animals; Brain; Central Nervous System Agents; Chronic Dis | 2014 |
Simultaneous real-time 3D photoacoustic tomography and EEG for neurovascular coupling study in an animal model of epilepsy.
Topics: Animals; Blood Vessels; Convulsants; Electroencephalography; Epilepsy; Image Processing, Computer-As | 2014 |
Pharmacoproteomics-based reconstruction of in vivo P-glycoprotein function at blood-brain barrier and brain distribution of substrate verapamil in pentylenetetrazole-kindled epilepsy, spontaneous epilepsy, and phenytoin treatment models.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barri | 2014 |
Normotopic cortex is the major contributor to epilepsy in experimental double cortex.
Topics: Animals; Bicuculline; Cerebral Cortex; Classical Lissencephalies and Subcortical Band Heterotopias; | 2014 |
Anticonvulsant and behavioral effects of muscimol in immature rats.
Topics: Age Factors; Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Dr | 2014 |
Curcumin supplementation improves mitochondrial and behavioral deficits in experimental model of chronic epilepsy.
Topics: Animals; Convulsants; Curcumin; Disease Models, Animal; Electron Transport Complex IV; Epilepsy; Kin | 2014 |
Elevated serotonergic signaling amplifies synaptic noise and facilitates the emergence of epileptiform network oscillations.
Topics: Animals; Computer Simulation; Electrodes, Implanted; Electroencephalography; Epilepsy; Excitatory Po | 2014 |
Novel fluorinated pyrrolo[1,2-a]pyrazine-2,6-dione derivatives: synthesis and anticonvulsant evaluation in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Ep | 2014 |
Effects of intravenous human umbilical cord blood mesenchymal stem cell therapy versus gabapentin in pentylenetetrazole-induced chronic epilepsy in rats.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Epilepsy; Female; Gabapentin; | 2014 |
Gestational treatment of folic acid attenuates blood-brain barrier leakage in pregnant- and prepubertal rats after pentylenetetrazole-induced seizure.
Topics: Animals; Blood Pressure; Blood-Brain Barrier; Epilepsy; Female; Folic Acid; Glial Fibrillary Acidic | 2016 |
The involvement of neuronal nitric oxide synthase in antiepileptic action of alpha-asarone on pentylenetetrazol molding rats.
Topics: Action Potentials; Allylbenzene Derivatives; Animals; Anisoles; Brain; Convulsants; Dose-Response Re | 2014 |
GABAB, not GABAA receptors play a role in cortical postictal refractoriness.
Topics: Animals; Azepines; Bicuculline; Cerebral Cortex; Electric Stimulation; Electrodes, Implanted; Epilep | 2015 |
Degeneration and regeneration of GABAergic interneurons in the dentate gyrus of adult mice in experimental models of epilepsy.
Topics: Animals; Chronic Disease; Dentate Gyrus; Epilepsy; GABAergic Neurons; Glutamate Decarboxylase; Green | 2015 |
Antiepileptogenic, antioxidant and genotoxic evaluation of rosmarinic acid and its metabolite caffeic acid in mice.
Topics: Animals; Anticonvulsants; Antioxidants; Blotting, Western; Caffeic Acids; Cells, Cultured; Cinnamate | 2015 |
Anxiolytic and antidepressive effects of electric stimulation of the paleocerebellar cortex in pentylenetetrazol kindled rats.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Biophysics; Cerebellar Cortex; Convulsants; Dis | 2014 |
Anticonvulsant effect of Cicer arietinum seed in animal models of epilepsy: introduction of an active molecule with novel chemical structure.
Topics: Animals; Anticonvulsants; Cicer; Disease Models, Animal; Electroshock; Epilepsy; Male; Mice; Pentyle | 2015 |
Design, synthesis and pharmacological evaluation of N-[4-(4-(alkyl/aryl/heteroaryl)-piperazin-1-yl)-phenyl]-carbamic acid ethyl ester derivatives as novel anticonvulsant agents.
Topics: Animals; Anticonvulsants; Carbamates; Drug Design; Electroshock; Epilepsy; Mice; Pentylenetetrazole; | 2015 |
Involvement of apoptosis and calcium accumulation through TRPV1 channels in neurobiology of epilepsy.
Topics: Animals; Apoptosis; Calcium; Capsaicin; Diterpenes; Epilepsy; Ganglia, Spinal; Hippocampus; Male; Ne | 2015 |
Effects of modafinil on pentylenetetrazol-induced convulsive epilepsy.
Topics: Animals; Anticonvulsants; Benzhydryl Compounds; Brain; Disease Models, Animal; Dose-Response Relatio | 2015 |
NMDA receptor NR2B subunits contribute to PTZ-kindling-induced hippocampal astrocytosis and oxidative stress.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Cell Death; Epilepsy; Excitatory Amino Acid | 2015 |
Grouping Pentylenetetrazol-Induced Epileptic Rats According to Memory Impairment and MicroRNA Expression Profiles in the Hippocampus.
Topics: Animals; Cluster Analysis; Computational Biology; Databases, Nucleic Acid; Disease Models, Animal; E | 2015 |
Type 1 diabetes exacerbates blood-brain barrier alterations during experimental epileptic seizures in an animal model.
Topics: Animals; Astrocytes; Blood Glucose; Blood Pressure; Blood-Brain Barrier; Convulsants; Cytokines; Dia | 2015 |
Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Docosahexaenoic Acids; Dose-Response Relationship, | 2015 |
Effect of GLT-1 modulator and P2X7 antagonists alone and in combination in the kindling model of epilepsy in rats.
Topics: Animals; Brain; Ceftriaxone; Cognition Disorders; Convulsants; Dose-Response Relationship, Drug; Epi | 2015 |
Unilateral microinjection of carbenoxolone into the pontis caudalis nucleus inhibits the pentylenetetrazole-induced epileptiform activity in rats.
Topics: Animals; Anticonvulsants; Carbenoxolone; Epilepsy; Male; Microinjections; Pentylenetetrazole; Pontin | 2015 |
Traumatic brain injury accelerates kindling epileptogenesis in rats.
Topics: Amygdala; Animals; Brain Injuries, Traumatic; Cerebral Cortex; Convulsants; Disease Models, Animal; | 2016 |
Metallothionein expression in the rat brain following KA and PTZ treatment.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Metallothionein; Oxidative Stre | 2015 |
Discovery of benzothiazine derivatives as novel, orally-active anti-epileptic drug candidates with broad anticonvulsant effect.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, | 2015 |
Sulforaphane is anticonvulsant and improves mitochondrial function.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electron Transport Complex I; Electro | 2015 |
The involvement of neuronal nitric oxide synthase in the anti-epileptic action of curcumin on pentylenetetrazol-kindled rats.
Topics: Animals; Anticonvulsants; Convulsants; Curcumin; Dose-Response Relationship, Drug; Enzyme Activation | 2015 |
Brain redox imaging in the pentylenetetrazole (PTZ)-induced kindling model of epilepsy by using in vivo electron paramagnetic resonance and a nitroxide imaging probe.
Topics: Animals; Ascorbic Acid; Brain; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Epilepsy; Glut | 2015 |
Disruption of polycystin-L causes hippocampal and thalamocortical hyperexcitability.
Topics: Animals; Calcium Channels; Cerebral Cortex; Cilia; Cyclic AMP; Cyclic AMP Response Element-Binding P | 2016 |
Lipopolysaccharide preconditioning prevents acceleration of kindling epileptogenesis induced by traumatic brain injury.
Topics: Analysis of Variance; Animals; Brain Injuries; Convulsants; Disease Models, Animal; Dose-Response Re | 2015 |
Neuroprotective Effect of Lycopene Against PTZ-induced Kindling Seizures in Mice: Possible Behavioural, Biochemical and Mitochondrial Dysfunction.
Topics: Animals; Antioxidants; Behavior, Animal; Brain; Carotenoids; Catalase; Dose-Response Relationship, D | 2016 |
Optogenetic activation of superior colliculus neurons suppresses seizures originating in diverse brain networks.
Topics: 4-Butyrolactone; Acoustic Stimulation; Animals; Brain Stem; Disease Models, Animal; Electrocorticogr | 2016 |
Epileptogenic effects of G protein-coupled estrogen receptor 1 in the rat pentylenetetrazole kindling model of epilepsy.
Topics: Animals; Cerebral Cortex; Cyclopentanes; Epilepsy; Estradiol; Kindling, Neurologic; Male; Pentylenet | 2016 |
MiR-181a influences the cognitive function of epileptic rats induced by pentylenetetrazol.
Topics: Animals; Cognition; Epilepsy; Hippocampus; Kindling, Neurologic; Male; MicroRNAs; Pentylenetetrazole | 2015 |
Antiepileptogenic effects of borneol in pentylenetetrazole-induced kindling in mice.
Topics: Animals; Anticonvulsants; Brain; Camphanes; Catalase; Convulsants; Disease Models, Animal; Epilepsy; | 2016 |
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagoni | 2016 |
Neurochemical modulation involved in the beneficial effect of liraglutide, GLP-1 agonist on PTZ kindling epilepsy-induced comorbidities in mice.
Topics: Animals; Comorbidity; Epilepsy; gamma-Aminobutyric Acid; Glucagon-Like Peptide 1; Glutamic Acid; Glu | 2016 |
Luteolin rescues pentylenetetrazole-induced cognitive impairment in epileptic rats by reducing oxidative stress and activating PKA/CREB/BDNF signaling.
Topics: Animals; Anticonvulsants; Brain; Brain-Derived Neurotrophic Factor; Cognition; Cognitive Dysfunction | 2016 |
NADPH oxidase activation is required for pentylenetetrazole kindling-induced hippocampal autophagy.
Topics: Animals; Autophagy; Brain Mapping; Disease Models, Animal; Epilepsy; Hippocampus; Humans; Kindling, | 2016 |
Ameliorative effect of Asparagus racemosus root extract against pentylenetetrazol-induced kindling and associated depression and memory deficit.
Topics: Animals; Anticonvulsants; Asparagus Plant; Depression; Dose-Response Relationship, Drug; Epilepsy; K | 2016 |
Prediction of seizure incidence probability in PTZ model of kindling through spatial learning ability in male and female rats.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy; Female; Kindling, Neurologic; Male; Maze Lea | 2016 |
Increased susceptibility to pentylenetetrazol following survival of cerebral malaria in mice.
Topics: Animals; Body Weight; Convulsants; Disease Models, Animal; Disease Susceptibility; Electroencephalog | 2016 |
Saikosaponin a functions as anti-epileptic effect in pentylenetetrazol induced rats through inhibiting mTOR signaling pathway.
Topics: Animals; Apoptosis; Down-Regulation; Epilepsy; Hippocampus; Interleukin-1beta; Leucine; Male; Neuron | 2016 |
Microarray Noninvasive Neuronal Seizure Recordings from Intact Larval Zebrafish.
Topics: Action Potentials; Animals; Brain; Electroencephalography; Electrophysiological Phenomena; Epilepsy; | 2016 |
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment.
Topics: Animals; Anticonvulsants; Brain; Callithrix; Carbamazepine; Chronic Disease; Disease Models, Animal; | 2016 |
Evidence in support of using a neurochemistry approach to identify therapy for both epilepsy and associated depression.
Topics: Animals; Anticonvulsants; Brain; Depression; Depressive Disorder; Disease Models, Animal; Dopamine; | 2016 |
Analysis of the Expressions of TrkB and GLT-1 in Brain Tissues on a Rat Pentylenetetrazol Kindling Model of Chronic Epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Transporter 2; Hippoca | 2016 |
15q13.3 homozygous knockout mouse model display epilepsy-, autism- and schizophrenia-related phenotypes.
Topics: Animals; Auditory Perceptual Disorders; Autistic Disorder; Behavior, Animal; Chromosome Deletion; Ch | 2016 |
Ferulic acid exhibits antiepileptogenic effect and prevents oxidative stress and cognitive impairment in the kindling model of epilepsy.
Topics: Animals; Anticonvulsants; Antioxidants; Avoidance Learning; Cognitive Dysfunction; Coumaric Acids; D | 2017 |
In silico Screening and Evaluation of the Anticonvulsant Activity of Docosahexaenoic Acid-Like Molecules in Experimental Models of Seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Docosahexaenoic Acids; Drug Design; Electroshock; | 2017 |
A Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical Stimulation.
Topics: Animals; Brain-Computer Interfaces; Epilepsy; Female; Male; Pentylenetetrazole; Rats, Long-Evans; Se | 2016 |
Subconvulsant doses of pentylenetetrazol uncover the epileptic phenotype of cultured synapsin-deficient Helix serotonergic neurons in the absence of excitatory and inhibitory inputs.
Topics: Action Potentials; Animals; Cells, Cultured; Convulsants; Dose-Response Relationship, Drug; Epilepsy | 2016 |
Aquaporin 4 inhibition decreased synthesis of cytokines by acetazolamide in the hippocampus of rats with pentrazol-induced chronic epilepsy.
Topics: Acetazolamide; Animals; Aquaporin 4; Chronic Disease; Cytokines; Epilepsy; Hippocampus; Kindling, Ne | 2016 |
Effect of lamotrigine on epilepsy-induced cognitive impairment and hippocampal neuronal apoptosis in pentylenetetrazole-kindled animal model.
Topics: Animals; Anticonvulsants; Apoptosis; CA1 Region, Hippocampal; Cognitive Dysfunction; Epilepsy; Femal | 2017 |
EGAR, A Food Protein-Derived Tetrapeptide, Reduces Seizure Activity in Pentylenetetrazole-Induced Epilepsy Models Through α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionate Receptors.
Topics: Animals; Anticonvulsants; CA1 Region, Hippocampal; Cells, Cultured; Disease Models, Animal; Epilepsy | 2017 |
Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism.
Topics: Animals; Anticonvulsants; Benzothiazoles; Calcium Channels; Cerebellum; Convulsants; Disease Models, | 2016 |
Garcinol Upregulates GABAA and GAD65 Expression, Modulates BDNF-TrkB Pathway to Reduce Seizures in Pentylenetetrazole (PTZ)-Induced Epilepsy.
Topics: Animals; Anticonvulsants; Apoptosis; Brain-Derived Neurotrophic Factor; Epilepsy; Glutamate Decarbox | 2016 |
AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets.
Topics: Aggrecans; Animals; Anticonvulsants; Behavior, Animal; Chondroitin ABC Lyase; Disease Models, Animal | 2016 |
Simple N,N-dimethyl phenylsulfonamides show potent anticonvulsant effect in two standard epilepsy models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Ep | 2017 |
Adjuvant neuronal nitric oxide synthase inhibition for combined treatment of epilepsy and comorbid depression.
Topics: Animals; Anticonvulsants; Chemotherapy, Adjuvant; Depression; Dose-Response Relationship, Drug; Enzy | 2017 |
The effects of linalool on the excitability of central neurons of snail Caucasotachea atrolabiata.
Topics: Action Potentials; Acyclic Monoterpenes; Animals; Anticonvulsants; Calcium Channel Blockers; Calcium | 2017 |
Adjuvant quercetin therapy for combined treatment of epilepsy and comorbid depression.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Combined Modality Therapy; Convulsants; Depressio | 2017 |
CDYL Deficiency Disrupts Neuronal Migration and Increases Susceptibility to Epilepsy.
Topics: Actin Cytoskeleton; Actins; Animals; Brain; Cell Movement; Cell Polarity; Chromatin; Co-Repressor Pr | 2017 |
Apelin-13 protects rat primary cortical glia-neuron co-culture against pentylenetetrazole-induced toxicity.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Antioxidants; Apoptosis; Calcium; Caspase 3; Cel | 2017 |
Trimetazidine potentiates the antiepileptic activity and ameliorates the metabolic changes associated with pentylenetetrazole kindling in rats treated with valproic acid.
Topics: Animals; Anticonvulsants; Aorta; Biomarkers; Blood Glucose; Drug Synergism; Epilepsy; Hippocampus; I | 2017 |
Analgesic, antiallodynic, and anticonvulsant activity of novel hybrid molecules derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide in animal models of pain and epilepsy.
Topics: Amides; Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Male; Mice; Motor Ac | 2017 |
Protective effect of spermine against pentylenetetrazole kindling epilepsy induced comorbidities in mice.
Topics: Animals; Arginine; Avoidance Learning; Brain; Catecholamines; Comorbidity; Depression; Epilepsy; gam | 2017 |
Obestatin improves oxidative brain damage and memory dysfunction in rats induced with an epileptic seizure.
Topics: Animals; Antioxidants; Brain; Brain Injuries; Disease Models, Animal; Epilepsy; Ghrelin; Glutathione | 2017 |
Cellular responses to recurrent pentylenetetrazole-induced seizures in the adult zebrafish brain.
Topics: Animals; Behavior, Animal; Brain; Convulsants; Disease Models, Animal; Epilepsy; Motor Activity; Pen | 2017 |
Synergistic anticonvulsant effects of pregabalin and amlodipine on acute seizure model of epilepsy in mice.
Topics: Amlodipine; Animals; Anticonvulsants; Disease Models, Animal; Drug Synergism; Drug Therapy, Combinat | 2017 |
Immunocytochemistry of neuron specific enolase (NSE) in the rat brain after single and repeated epileptic seizures.
Topics: Animals; Biomarkers; Brain; Brain Mapping; Convulsants; Dose-Response Relationship, Drug; Energy Met | 2008 |
Antiepileptic effect of electroacupuncture vs. vagus nerve stimulation in the rat thalamus.
Topics: Action Potentials; Acupuncture Points; Animals; Disease Models, Animal; Dose-Response Relationship, | 2008 |
Cyclin D1 in excitatory neurons of the adult brain enhances kainate-induced neurotoxicity.
Topics: Adult; Animals; Apoptosis; Convulsants; Cyclin D1; Disease Models, Animal; Epilepsy; Female; Hippoca | 2008 |
Anticonvulsant effect of a natural compound alpha,beta-epoxy-carvone and its action on the nerve excitability.
Topics: Action Potentials; Animals; Anticonvulsants; Convulsants; Cyclohexane Monoterpenes; Disease Models, | 2008 |
Cl(-) conduction of GABAA receptor complex of synaptic membranes in the cortex of rats at the middle stage of chronic cerebral epileptization (pharmacological kindling).
Topics: Animals; Cerebral Cortex; Chlorides; Chronic Disease; Dose-Response Relationship, Drug; Epilepsy; GA | 2007 |
Impaired spatial learning related with decreased expression of calcium/calmodulin-dependent protein kinase IIalpha and cAMP-response element binding protein in the pentylenetetrazol-kindled rats.
Topics: Animals; Blotting, Western; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein | 2008 |
Topiramate and vitamin e modulate antioxidant enzyme activities, nitric oxide and lipid peroxidation levels in pentylenetetrazol-induced nephrotoxicity in rats.
Topics: Animals; Anticonvulsants; Antioxidants; Catalase; Dose-Response Relationship, Drug; Drug Therapy, Co | 2008 |
Developmental impact of a familial GABAA receptor epilepsy mutation.
Topics: Animals; Brain; Brain Chemistry; Convulsants; Disease Models, Animal; Epilepsy; gamma-Aminobutyric A | 2008 |
The neurosteroid environment in the hippocampus exerts bi-directional effects on seizure susceptibility in mice.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Alcohol-Induced Disorders, Nerv | 2008 |
The fruit essential oil of Pimpinella anisum L. (Umblliferae) induces neuronal hyperexcitability in snail partly through attenuation of after-hyperpolarization.
Topics: Action Potentials; Animals; Anticonvulsants; Calcium Channels; Convulsants; Disease Models, Animal; | 2008 |
Fenofibrate, a peroxisome proliferator-activated receptor-alpha agonist, exerts anticonvulsive properties.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Body Weight; Diet, Ketogenic; Disease Models, | 2009 |
Pharmacological screening of Malian medicinal plants used against epilepsy and convulsions.
Topics: Animals; Anticonvulsants; Epilepsy; GABA-A Receptor Agonists; In Vitro Techniques; Male; Mali; Mice; | 2009 |
Age-dependent anticonvulsant action of antagonists of group I glutamate metabotropic receptors in rats.
Topics: Aging; Analysis of Variance; Animal Diseases; Animals; Animals, Newborn; Anticonvulsants; Dicarboxyl | 2009 |
Effects of progesterone on total brain tissue adenosine deaminase activity in experimental epilepsy.
Topics: Adenosine; Adenosine Deaminase; Animals; Brain; Convulsants; Disease Models, Animal; Epilepsy; Femal | 2009 |
Effects of selenium and topiramate on lipid peroxidation and antioxidant vitamin levels in blood of pentylentetrazol-induced epileptic rats.
Topics: Animal Feed; Animals; Antioxidants; Epilepsy; Erythrocytes; Fructose; Glutathione; Glutathione Perox | 2009 |
Synthesis and anticonvulsant activity of 5-chloro-2(3H)-benzoxazolinone-3-acetyl-2-(o/p-substituted benzal) hydrazone derivatives.
Topics: Animals; Anticonvulsants; Convulsants; Epilepsy; Hydrazones; Magnetic Resonance Spectroscopy; Male; | 2008 |
Antiepileptic activity of melatonin in guinea pigs with pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Brain; Central Nervous System Depressants; Convulsants; Disease Models, An | 2009 |
[Hippocampal mossy fiber sprouting and Cdk5/p35 expressions in the pentylenetetrazole kindling rat model].
Topics: Animals; Cyclin-Dependent Kinase 5; Epilepsy; Kindling, Neurologic; Male; Mossy Fibers, Hippocampal; | 2008 |
A Drosophila systems model of pentylenetetrazole induced locomotor plasticity responsive to antiepileptic drugs.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drosophila; Epilepsy; Gene Expression Profiling; G | 2009 |
Validation of anticonvulsant and sedative activity of six medicinal plants.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Electroshock; Epi | 2009 |
Antiepileptogenic effects of glutathione against increased brain ADA in PTZ-induced epilepsy.
Topics: Adenosine Deaminase; Analysis of Variance; Animals; Anticonvulsants; Brain; Convulsants; Epilepsy; F | 2009 |
Pentylenetetrazole-induced seizures affect binding site densities for GABA, glutamate and adenosine receptors in the rat brain.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Convulsants; Disease Models, Animal; Epilepsy; | 2009 |
Interaction of tiagabine with valproate in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves.
Topics: Animals; Anticonvulsants; Brain Chemistry; Convulsants; Dose-Response Relationship, Drug; Drug Inter | 2009 |
Single injection of a low dose of pentylenetetrazole leads to epileptogenesis in an animal model of cortical dysplasia.
Topics: Age Factors; Animals; Animals, Newborn; Convulsants; Disease Models, Animal; Electroencephalography; | 2009 |
Anticonvulsant and antiepileptic actions of 2-deoxy-D-glucose in epilepsy models.
Topics: Animals; Anticonvulsants; Deoxyglucose; Disease Models, Animal; Dose-Response Relationship, Drug; El | 2009 |
The effects of group III mGluR ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Convulsants; Disease Models, Animal; Dose-Response Re | 2009 |
Antagonists of group I metabotropic glutamate receptors and cortical afterdischarges in immature rats.
Topics: Animals; Animals, Newborn; Anticonvulsants; Cerebral Cortex; Convulsants; Electroencephalography; Ep | 2009 |
Proepileptic phenotype of SV2A-deficient mice is associated with reduced anticonvulsant efficacy of levetiracetam.
Topics: Amygdala; Animals; Anticonvulsants; Binding Sites; Brain; Disease Models, Animal; Electroshock; Epil | 2009 |
Adenosine A2A receptor deficient mice are partially resistant to limbic seizures.
Topics: Adenosine; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Male; Mice; Mic | 2009 |
Maternal epileptic seizure induced by pentylenetetrazol: apoptotic neurodegeneration and decreased GABAB1 receptor expression in prenatal rat brain.
Topics: Animals; Apoptosis; Brain; Caspase 3; Cyclic AMP-Dependent Protein Kinases; Cytochromes c; Electroen | 2009 |
Preferential increase in the hippocampal synaptic vesicle protein 2A (SV2A) by pentylenetetrazole kindling.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Mem | 2009 |
Anticonvulsant effects of Searsia dentata (Anacardiaceae) leaf extract in rats.
Topics: Anacardiaceae; Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Epilepsy; Kainic Acid; | 2010 |
[Intranasal administration of low dosage recombinant human erythropoietin inhibits seizure in rats].
Topics: Administration, Intranasal; Animals; Anticonvulsants; Epilepsy; Erythropoietin; Humans; Male; Pentyl | 2009 |
Anticonvulsant activity of DNS II fraction in the acute seizure models.
Topics: Acetone; Animals; Anticonvulsants; Delphinium; Diazepam; Epilepsy; Male; Melanoma; Mice; Mice, Inbre | 2010 |
Δ⁹-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats.
Topics: Animals; Cerebral Cortex; Competitive Bidding; Disease Models, Animal; Dronabinol; Drug Interactions | 2010 |
Combined effects of epileptic seizure and phenobarbital induced overexpression of P-glycoprotein in brain of chemically kindled rats.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Behavior, Animal; B | 2010 |
[Understanding the pathophysiology of epilepsy in an animal model: pentylenetetrazole induces activation but not death of neurons of the medial extended amygdala].
Topics: Amygdala; Animals; Convulsants; Disease Models, Animal; Epilepsy; Humans; Male; Nerve Degeneration; | 2010 |
Amygdala-specific reduction of alpha1-GABAA receptors disrupts the anticonvulsant, locomotor, and sedative, but not anxiolytic, effects of benzodiazepines in mice.
Topics: Amygdala; Animals; Animals, Newborn; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Cell Lin | 2010 |
Antioxidant potential of curcumin against oxidative insult induced by pentylenetetrazol in epileptic rats.
Topics: Alkaloids; Animals; Antioxidants; Benzodioxoles; Biological Availability; Carbamazepine; Catalase; C | 2010 |
Long-term efficacy and safety of human umbilical cord mesenchymal stromal cells in rotenone-induced hemiparkinsonian rats.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apomorphine; Brain; Carbocyanines; Cell Differentiati | 2010 |
Synthesis and anticonvulsant activity of new 6-methyl-1-substituted-4,6-diazaspiro[2.4]heptane-5,7-diones.
Topics: Animals; Anticonvulsants; Electroshock; Epilepsy; Heptanes; Male; Mice; Pentylenetetrazole; Structur | 2010 |
Neonatal exposure to low-dose domoic acid lowers seizure threshold in adult rats.
Topics: Action Potentials; Animals; Animals, Newborn; Convulsants; Disease Models, Animal; Epilepsy; Kainic | 2010 |
Targeting γ-aminobutyric acid (GABA) carriers to the brain: potential relevance as antiepileptic pro-drugs.
Topics: Animals; Blood-Brain Barrier; Epilepsy; Female; GABA Agonists; gamma-Aminobutyric Acid; Male; Mice; | 2010 |
Epileptogenic insult alters endogenous adenosine control on long-term changes in synaptic strength by theta pattern stimulation in hippocampus area CA1.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Convulsants; Epilepsy; Excitatory Postsynapti | 2011 |
Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy.
Topics: Action Potentials; Animals; Cell Line; Cells, Cultured; Convulsants; Epilepsy; Ether-A-Go-Go Potassi | 2010 |
Comparative pharmacodynamic and pharmacokinetic analysis of two anticonvulsant halo derivatives of 2,2,3,3-tetramethylcyclopropanecarboxamide, an amide of a cyclic analog of valproic acid.
Topics: Abnormalities, Drug-Induced; Amides; Analgesics; Animals; Anticonvulsants; Cyclopropanes; Disease Mo | 2010 |
[Effect of Chaihu Shugan Tang on excitability in different brain regions of pentylenetetrazole-kindled chronic epileptic rats].
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Aspartic Acid; Brain; Chronic Disease; Deoxyglucose; Disease | 2010 |
Halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine produces beneficial effects in experimental stroke and seizures.
Topics: Animals; Blood Pressure; Brain; Caspase 3; Disease Models, Animal; Endothelin-1; Epilepsy; Heart Rat | 2011 |
Early seizure detection in rats based on vagus nerve activity.
Topics: Animals; Convulsants; Early Diagnosis; Electrodiagnosis; Epilepsy; Pentylenetetrazole; Rats; Rats, S | 2011 |
Anticonvulsant action of drugs against metrazol and anti-epileptic activity.
Topics: Anticonvulsants; Epilepsy; Pentylenetetrazole; Seizures | 1946 |
Distinct temporal patterns of electrical stimulation influence neural recruitment during PTZ infusion: an fMRI study.
Topics: Amygdala; Animals; Brain Mapping; Electric Stimulation; Electroencephalography; Epilepsy; Humans; Ma | 2011 |
Imidazolylchromanone oxime ethers as potential anticonvulsant agents: Anticonvulsive evaluation in PTZ-kindling model of epilepsy and SAR study.
Topics: Animals; Anticonvulsants; Benzopyrans; Epilepsy; Humans; Kindling, Neurologic; Oximes; Pentylenetetr | 2011 |
Anticonvulsant effect of celecoxib on pentylenetetrazole-induced convulsion: Modulation by NO pathway.
Topics: Animals; Anticonvulsants; Arginine; Celecoxib; Disease Models, Animal; Dose-Response Relationship, D | 2010 |
The evaluation of nitric oxide involvement in metrazol induced status epilepticus using multiparametric monitoring.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Femoral Vein; Infusions, Intravenous; Male; Monito | 2011 |
Study of epileptiform activity in cerebral ganglion of mud crab Scylla serrata.
Topics: Animals; Anticonvulsants; Brachyura; Convulsants; Disease Models, Animal; Epilepsy; gamma-Aminobutyr | 2011 |
Myelin damage of hippocampus and cerebral cortex in rat pentylenetetrazol model.
Topics: Animals; Autoantibodies; Blood-Brain Barrier; Blotting, Western; Cerebral Cortex; Electroencephalogr | 2011 |
Does ghrelin level change after epileptic seizure in rats?
Topics: Animals; Convulsants; Epilepsy; Ghrelin; Male; Pentylenetetrazole; Rats; Rats, Wistar | 2011 |
Synthesis and anticonvulsant activity of 8-alkoxy-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1]benzazepin-1-one derivatives.
Topics: Animals; Anticonvulsants; Benzazepines; Electroshock; Epilepsy; Mice; Nervous System; Pentylenetetra | 2011 |
Anticonvulsant and antioxidant actions of trimetazidine in pentylenetetrazole-induced kindling model in mice.
Topics: Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Ep | 2011 |
Focused ultrasound-mediated suppression of chemically-induced acute epileptic EEG activity.
Topics: Animals; Brain; Brain Waves; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, | 2011 |
A neuroprotective role for polyamines in a Xenopus tadpole model of epilepsy.
Topics: Animals; Convulsants; Cytoprotection; Disease Models, Animal; Epilepsy; Larva; Organ Culture Techniq | 2011 |
Topiramate modulates hippocampus NMDA receptors via brain Ca(2+) homeostasis in pentylentetrazol-induced epilepsy of rats.
Topics: Animals; Calcium; Calcium-Transporting ATPases; Epilepsy; Fructose; Hippocampus; Homeostasis; Intrac | 2011 |
Detection of nonlinear interactions of EEG alpha waves in the brain by a new coherence measure and its application to epilepsy and anti-epileptic drug therapy.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Convulsants; Electroencephalography; Epilepsy; Ethosuximi | 2011 |
Recording the adult zebrafish cerebral field potential during pentylenetetrazole seizures.
Topics: Action Potentials; Amplifiers, Electronic; Animals; Behavior, Animal; Cerebrum; Convulsants; Disease | 2011 |
Neuroprotective effect of vitamin C against PTZ induced apoptotic neurodegeneration in adult rat brain.
Topics: Animals; Apoptosis; Ascorbic Acid; Brain; Caspase 3; Disease Models, Animal; Epilepsy; Male; Nerve D | 2011 |
Closed-loop seizure control on epileptic rat models.
Topics: Animals; Artificial Intelligence; Brain; Convulsants; Disease Models, Animal; Electric Impedance; El | 2011 |
Synthesis and anticonvulsant activity of novel 2,6-diketopiperazine derivatives. Part 1: perhydropyrrole[1,2-a]pyrazines.
Topics: Animals; Anticonvulsants; Diketopiperazines; Electroshock; Epilepsy; Humans; Male; Mice; Models, Mol | 2011 |
Sulfobutyl ether(7) β-cyclodextrin (SBE(7) β-CD) carbamazepine complex: preparation, characterization, molecular modeling, and evaluation of in vivo anti-epileptic activity.
Topics: Administration, Oral; Animals; Anticonvulsants; beta-Cyclodextrins; Calorimetry, Differential Scanni | 2011 |
Liposomal formulation of curcumin attenuates seizures in different experimental models of epilepsy in mice.
Topics: Animals; Anticonvulsants; Biological Availability; Chemistry, Pharmaceutical; Curcumin; Disease Mode | 2013 |
Creatine reduces oxidative stress markers but does not protect against seizure susceptibility after severe traumatic brain injury.
Topics: Animals; Brain Injuries; Creatine; Dietary Supplements; Disease Models, Animal; Electroencephalograp | 2012 |
Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models.
Topics: Acetates; Animals; Anticonvulsants; Antioxidants; Catalase; Corpus Striatum; Disease Models, Animal; | 2011 |
Synthesis and anticonvulsant evaluation of dimethylethanolamine analogues of valproic acid and its tetramethylcyclopropyl analogue.
Topics: Animals; Anticonvulsants; Brain Waves; Convulsants; Cyclopropanes; Deanol; Disease Models, Animal; E | 2012 |
Dual protective effect of Passiflora incarnata in epilepsy and associated post-ictal depression.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Behavior, Animal; Brain; Convulsants; Depression; E | 2012 |
Age dependent learning and memory deficit in Pentylenetetrazol kindled mice.
Topics: Aging; Animals; Behavior, Animal; Disease Models, Animal; Epilepsy; Feasibility Studies; Learning; M | 2012 |
Wireless and batteryless biomedical microsystem for neural recording and epilepsy suppression based on brain focal cooling.
Topics: Animals; Brain; Electroencephalography; Electromyography; Epilepsy; Equipment Design; Hypothermia, I | 2011 |
Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy.
Topics: Action Potentials; Animals; Biophysics; Caveolin 1; Cell Line, Transformed; Disease Models, Animal; | 2011 |
Pentylenetetrazole-induced seizures cause acute, but not chronic, mTOR pathway activation in rat.
Topics: Acute Disease; Animals; Chronic Disease; Convulsants; Disease Models, Animal; Enzyme Activation; Epi | 2012 |
Diagnostic yield and predictive value of provoked ictal SPECT in drug-resistant epilepsies.
Topics: Adult; Drug Resistance; Epilepsy; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pentylenetet | 2012 |
Acute seizure tests in epilepsy research: electroshock- and chemical-induced convulsions in the mouse.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Dru | 2009 |
Effect of medroxyprogesterone on development of pentylenetetrazole-induced kindling in mice.
Topics: Animals; Anticonvulsants; Contraceptives, Oral, Synthetic; Convulsants; Disease Models, Animal; Epil | 2012 |
Anticonvulsant effect of retigabine during postnatal development in rats.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Carbamates; Convulsants; Dose-Response Relationsh | 2012 |
The effect of PTZ-induced epileptic seizures on hippocampal expression of PSA-NCAM in offspring born to kindled rats.
Topics: Animals; Epilepsy; Female; Gene Expression Regulation, Developmental; Hippocampus; Kindling, Neurolo | 2012 |
The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats.
Topics: Age Factors; Animals; Anti-Allergic Agents; Brain; Caffeine; Central Nervous System Stimulants; Dibe | 2012 |
Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures.
Topics: Animals; Anticonvulsants; Central Nervous System; Disease Models, Animal; Drug Evaluation, Preclinic | 2012 |
Environmental enrichment restores cognitive deficits induced by prenatal maternal seizure.
Topics: Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Cell Count; Cognition Disorders; Convu | 2012 |
[Effect of pingxian granules on protein expression of apoptosis regulatory genes in hippocampus of pentylenetetrazol-induced epileptic model rats].
Topics: Animals; Apoptosis; Drugs, Chinese Herbal; Epilepsy; Female; Hippocampus; Immunohistochemistry; Male | 2012 |
ONO-2506 inhibits spike-wave discharges in a genetic animal model without affecting traditional convulsive tests via gliotransmission regulation.
Topics: Animals; Anticonvulsants; Astrocytes; Caprylates; Cells, Cultured; Convulsants; Disease Models, Anim | 2013 |
The role of ethanol on the anticonvulsant effect of valproic acid and cortical microvascular changes after epileptogenesis in mice.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Cerebrovascular Circulation; Drug Synergism; Drug Therapy | 2013 |
Protective activity of α-lactoalbumin (ALAC), a whey protein rich in tryptophan, in rodent models of epileptogenesis.
Topics: Animals; Convulsants; Epilepsy; Epilepsy, Absence; Excitatory Amino Acid Agonists; Excitatory Amino | 2012 |
Pentylenetetrazol (PTZ) kindling model of epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Kindling, Neurologic; Mice; Pentylenetetrazole | 2012 |
Effects of extremely low frequency electromagnetic field (50 Hz) on pentylenetetrazol-induced seizures in mice.
Topics: Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Radiation; Electromagnetic | 2013 |
Overexpression of multidrug resistance-associated protein 2 in the brain of pentylenetetrazole-kindled rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Chromatography, Liquid; Coloring Agents; Conv | 2012 |
Evaluation of the possible epileptogenic activity of ciprofloxacin: the role of Nigella sativa on amino acids neurotransmitters.
Topics: Amino Acids; Animals; Anti-Bacterial Agents; Anticonvulsants; Antioxidants; Brain Chemistry; Chromat | 2013 |
Differential seizure response in two models of cortical heterotopia.
Topics: Agenesis of Corpus Callosum; Animals; Cerebral Cortex; Choristoma; Convulsants; Disease Models, Anim | 2013 |
Comparison and effects of acute lamotrigine treatment on extracellular excitatory amino acids in the hippocampus of PTZ-kindled epileptic and PTZ-induced status epilepticus rats.
Topics: Animals; Aspartic Acid; Epilepsy; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kin | 2013 |
[Effects of Wuling mycelia on pentylenetetrazole-induced epilepsy in rats].
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Epilepsy; Hippocampus; Histamine; Kindling, | 2012 |
Oxytocin inhibits pentylentetrazol-induced seizures in the rat.
Topics: Animals; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy; Male; Oxyt | 2013 |
[The antiepileptic role of 3α-androstanediol on the epileptic rats induced by pentylenetetrazole].
Topics: Androstane-3,17-diol; Animals; Anticonvulsants; Electroencephalography; Epilepsy; Male; Pentylenetet | 2012 |
[Effect of acute stress stimulation on the seizure induction in epileptic model rats].
Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy; Lithium Chloride; Pentylenetetrazole; P | 2012 |
Behavioural and histopathological assessment of the effects of periodic fasting on pentylenetetrazol-induced seizures in rats.
Topics: Animals; Apoptosis; Disease Models, Animal; Epilepsy; Fasting; Hippocampus; Male; Neurons; Pentylene | 2013 |
Mechanisms of prickle1a function in zebrafish epilepsy and retinal neurogenesis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Dose-Response Relationship, Drug; Embryo, Nonmammalia | 2013 |
Seizures induced by pentylenetetrazole in the adult zebrafish: a detailed behavioral characterization.
Topics: Animals; Behavior, Animal; Brain; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Relat | 2013 |
Capparis ovata modulates brain oxidative toxicity and epileptic seizures in pentylentetrazol-induced epileptic rats.
Topics: Animals; Antioxidants; beta Carotene; Brain; Capparis; Cerebral Cortex; Electroencephalography; Epil | 2013 |
Ketogenic diet: does acetone stop seizures?
Topics: Acetone; Animals; Anticonvulsants; Cerebrospinal Fluid; Convulsants; Diet; Epilepsy; Fasting; Humans | 2002 |
Inhibitory effects of succinic acid on chemical kindling and amygdala electrical kindling in rats.
Topics: Amygdala; Animals; Anticonvulsants; Electric Stimulation; Epilepsy; Female; Kindling, Neurologic; Ma | 2002 |
Secretory phospholipase A2 and phospholipids in neural membranes in an experimental epilepsy model.
Topics: Animals; Cell Membrane; Cerebellum; Cerebral Cortex; Convulsants; Disease Models, Animal; Epilepsy; | 2002 |
In vitro inhibition of pentylenetetrazole and bicuculline-induced epileptiform activity in rat hippocampal pyramidal neurons by aqueous fraction isolated from Delphinium denudatum.
Topics: Animals; Animals, Newborn; Anticonvulsants; Bicuculline; Cells, Cultured; Delphinium; Epilepsy; GABA | 2002 |
Cysteamine pre-treatment reduces pentylenetetrazol-induced plasticity and epileptiform discharge in the CA1 region of rat hippocampal slices.
Topics: Action Potentials; Animals; Cysteamine; Epilepsy; Excitatory Postsynaptic Potentials; Hippocampus; I | 2002 |
Consequences of nitric oxide generation in epileptic-seizure rodent models as studied by in vivo EPR.
Topics: Analysis of Variance; Animals; Brain; Disease Models, Animal; Electron Spin Resonance Spectroscopy; | 2002 |
Contribution of ionotropic glutamate receptors and voltage-dependent calcium channels to the potentiation phenomenon induced by transient pentylenetetrazol in the CA1 region of rat hippocampal slices.
Topics: Adenosine; Animals; Calcium Channel Blockers; Calcium Channels; Epilepsy; Evoked Potentials; GABA An | 2003 |
[The influence of vagus nerve stimulation on NMDAR1 mRNA and GABAAR alpha 1 mRNA in thalamic reticular neucus of pentylenetetrazole-induced epileptic rats].
Topics: Animals; Electric Stimulation Therapy; Epilepsy; Intralaminar Thalamic Nuclei; Male; Pentylenetetraz | 2002 |
[Experimental pharmacodynamic study on the anti-convulsion effect of shenpu decoction].
Topics: Animals; Anticonvulsants; Drugs, Chinese Herbal; Electric Stimulation; Epilepsy; Male; Mice; Pentyle | 2001 |
Neuraminidase activity in different regions of the seizing epileptic and non-epileptic brain.
Topics: Animals; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Convulsants; Epilepsy; GABA Antagonists; Hi | 2003 |
Kindling status in sprague-dawley rats induced by pentylenetetrazole: involvement of a critical development period.
Topics: Animals; Biomarkers; Blotting, Northern; Disease Models, Animal; Disease Susceptibility; Epilepsy; G | 2003 |
Modulation of cortical nitric oxide synthase, glutamate, and redox state by nifedipine and taurine in PTZ-kindled mice.
Topics: Animals; Anticonvulsants; Antioxidants; Calcium; Calcium Channel Blockers; Cerebral Cortex; Dose-Res | 2003 |
Paroxysmal depolarization shifts (PDS) induce non-synaptic responses in neighboured neurons (buccal ganglia, Helix pomatia).
Topics: Animals; Calcium; Electric Stimulation; Epilepsy; GABA Antagonists; Ganglia, Invertebrate; Helix, Sn | 2003 |
Endogenous pacemaker potentials develop into paroxysmal depolarization shifts (PDSs) with application of an epileptogenic drug.
Topics: Animals; Aplysia; Biological Clocks; Convulsants; Electric Stimulation; Epilepsy; Excitatory Postsyn | 2003 |
Changes in nucleotide hydrolysis in rat blood serum induced by pentylenetetrazol-kindling.
Topics: 5'-Nucleotidase; Adenine Nucleotides; Adenosine; Animals; Apyrase; Biomarkers; Brain; Convulsants; D | 2003 |
The pentylenetetrazole-kindling model of epilepsy in SAMP8 mice: glial-neuronal metabolic interactions.
Topics: Acetic Acid; Age Factors; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Epilepsy; G | 2003 |
On the state of convulsion-readiness (Krampfbereitschaft) of the epileptics.
Topics: Epilepsy; Humans; Pentylenetetrazole; Seizures | 1951 |
[Value of cardiazol threshold in the diagnosis of epilepsy].
Topics: Aged; Epilepsy; Humans; Pentylenetetrazole | 1952 |
Activation of EEG disturbances with metrazol (pentazol) in epileptics, normals and patients with syncopal attacks.
Topics: Electroencephalography; Epilepsy; Humans; Pentylenetetrazole; Syncope | 1952 |
Response of experimental epileptic foci to intravenous and topical metrazol.
Topics: Electroencephalography; Epilepsy; Pentylenetetrazole | 1952 |
Effect on the electrical activity of the brain of intra-arterially and intra-cerebrally injected convulsant and sedative drugs (metrazol and nembutal).
Topics: Barbiturates; Brain; Convulsants; Electroencephalography; Epilepsy; Humans; Hypnotics and Sedatives; | 1952 |
[The point of peripheral impact of coramine, cardiazol, picrotoxin and scilliroside and their relation to cholinergic action. I].
Topics: Bufanolides; Cholinergic Agents; Disease; Epilepsy; Muscles; Nikethamide; Pentylenetetrazole; Picrot | 1953 |
Convulsive threshold values to parenterally injected pentamethylenetetrazole in epileptic monkeys.
Topics: Animals; Epilepsy; Haplorhini; Humans; Pentylenetetrazole; Seizures | 1953 |
Intracarotid and intravertebral metrazol in petit mal epilepsy.
Topics: Epilepsy; Epilepsy, Absence; Pentylenetetrazole | 1953 |
[Activation of bioelectric manifestations of epilepsy in electroencephalography with cardiazol].
Topics: Electroencephalography; Electrophysiological Phenomena; Epilepsy; Pentylenetetrazole | 1953 |
Photo-metrazol activation in children.
Topics: Child; Electroencephalography; Epilepsy; Humans; Infant; Mental Disorders; Pentylenetetrazole | 1954 |
The metrazol-flicker threshold in neuro-psychiatric patients.
Topics: Electroencephalography; Epilepsy; Humans; Mental Disorders; Patients; Pentylenetetrazole | 1954 |
[Electrical and clinical comparison of spontaneous temporal seizure and of the effect of cardiazol in the same patient; film presentation].
Topics: Epilepsy; Humans; Pentylenetetrazole; Seizures | 1953 |
Metrazol activation as a diagnostic adjunct in electroencephalography; a reevaluation.
Topics: Electroencephalography; Epilepsy; Pentylenetetrazole | 1954 |
The significance of spike-dome discharge in the metrazol-activated electroencephalogram.
Topics: Body Fluids; Electroencephalography; Epilepsy; Humans; Patient Discharge; Pentylenetetrazole | 1954 |
[Metrazólica photo-activation, epilepsy and thalamocortical connections].
Topics: Cerebral Cortex; Epilepsy; Light; Nervous System Physiological Phenomena; Pentylenetetrazole; Seizur | 1955 |
[Use of the convulsion test with oral cardiazol in diagnosis of epilepsy].
Topics: Epilepsy; Humans; Pentylenetetrazole; Seizures | 1956 |
[Electro-clinical study of induced seizures as method of detection and diagnosis of epilepsy].
Topics: Biomedical Research; Epilepsy; Humans; Pentylenetetrazole; Seizures | 1956 |
[Danger of precipitation of seizure by cardiazol activation during electroencephalographic studies].
Topics: Electroencephalography; Epilepsy; Humans; Immune System Phenomena; Pentylenetetrazole; Seizures | 1957 |
[Study of the protection brought about by phenothiazine derivatives, steroids & tranquilizing agents against pentylenetetrazole-induced epilepsy in rabbits under EEG control].
Topics: Animals; Antipsychotic Agents; Electroencephalography; Epilepsy; Humans; Pentylenetetrazole; Phenoth | 1958 |
[Electroencephalographic study of a new analeptic, dioxone, in the diagnosis of epilepsy and its comparison with pentamethylenetetrazole].
Topics: Central Nervous System Stimulants; Electroencephalography; Epilepsy; Humans; Pentylenetetrazole | 1961 |
[Study of new means for electro-encephalographic activation in epileptics. Effects of Toce (Dioxone) in comparison with Megimide and Cardiazol].
Topics: Bemegride; Central Nervous System Stimulants; Epilepsy; Pentylenetetrazole | 1961 |
[Megimide and cardiazol: comparison of their activating action on the electroencephalogram in epileptic subjects].
Topics: Bemegride; Central Nervous System Stimulants; Electroencephalography; Epilepsy; Pentylenetetrazole | 1959 |
The relation of metrazol EEG-convulsant threshold and alpha index.
Topics: Convulsants; Electroencephalography; Epilepsy; Humans; Pentylenetetrazole | 1962 |
[Experimental research on the relation between female sex steroids and epilepsy. I. Action of progesterone and estrone sulfate on the metrazole test].
Topics: Epilepsy; Estrone; Female; Pentylenetetrazole; Progesterone; Seizures; Steroids | 1962 |
[The photo-cardiazol test in military medicine].
Topics: Electroencephalography; Epilepsy; Humans; Light; Military Medicine; Pentylenetetrazole | 1963 |
[A contribution to the blood supply and oxygen uptake of the brain in minor epileptic attacks. Cerebral blood supply and 02 uptake in petit mal].
Topics: Blood Pressure; Brain; Electroencephalography; Energy Metabolism; Epilepsy; Epilepsy, Absence; Human | 1962 |
THE INFLUENCE OF EXPERIMENTAL CEREBRAL HYPOXIA ON CONVULSIVE RESPONSES TO CARDIAZOL.
Topics: Carotid Artery Thrombosis; Cats; Cerebrovascular Disorders; Electroencephalography; Epilepsy; Hypoxi | 1963 |
[COMPARATIVE PATHOPHYSIOLOGY OF THE EPILEPTIC SEIZURE].
Topics: Convulsive Therapy; Electricity; Electroconvulsive Therapy; Electroencephalography; Epilepsy; Humans | 1964 |
[CLINICAL MANIFESTATIONS OF TEMPORAL EPILEPSY OBSERVED DURING CARDIAZOL ACTIVATION].
Topics: Automatism; Cyanosis; Deglutition Disorders; Electroencephalography; Epilepsy; Epilepsy, Temporal Lo | 1963 |
[PERMANENT DEFICIENCY OF FIXATION MEMORY AFTER UNILATERAL TEMPORAL LOBECTOMY IN AN EPILEPTIC SUBJECT].
Topics: Amnesia; Bemegride; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Cloni | 1964 |
DEPTH RECORDING FROM THE HUMAN BRAIN IN EPILEPSY.
Topics: Adolescent; Amygdala; Astrocytoma; Bemegride; Caudate Nucleus; Child; Chlorpromazine; Electroencepha | 1963 |
[ELECTROENCEPHALOGRAPHIC EXPERIMENTATION WITH 2 NEW ACTIVATORS: TOCEN AND HEXACYCLONATE (GEVILON)].
Topics: Bemegride; Biomedical Research; Central Nervous System Stimulants; Cyclohexanecarboxylic Acids; Elec | 1963 |
[ZEAL, RISK AND RESPONSIBILITY IN ELECTROENCEPHALOGRAPHY].
Topics: Bemegride; Carotid Arteries; Death; Death, Sudden; Electroencephalography; Epilepsy; Humans; Light; | 1964 |
CHEMICAL AND PHARMACOLOGICAL SCREENING OF VALERIANA WALLICHI, LALLEMENTIA ROYLEANA, BREYNIA RHAMNOIDES AND EVOLVULUS NUMULARIANS FOR SEDATIVE AND ANTICONVULSANT PRINCIPLES.
Topics: Anticonvulsants; Chemical Phenomena; Chemistry; Convolvulaceae; Electroencephalography; Epilepsy; Hy | 1963 |
[THE ANTICONVULSANT ACTIVITY OF ARISAEMA JAPONICUM BL].
Topics: Anticonvulsants; Arisaema; Caffeine; Electric Injuries; Epilepsy; Mice; Pentylenetetrazole; Pharmaco | 1964 |
MESIAL CEREBRAL INCISION.
Topics: Animals; Behavior, Animal; Brain; Cerebellum; Cerebral Cortex; Cerebral Ventricles; Corpus Callosum; | 1963 |
EFFECT OF ANOXIC-ISCHEMIC PROCEDURE ON EXPERIMENTAL EPILEPSY IN THE RAT.
Topics: Brain Ischemia; Cerebral Infarction; Cobalt; Epilepsy; Hypoxia, Brain; Infarction; Ischemic Attack, | 1964 |
NOTE ON THE INTERACTIONS OF AMPHETAMINE WITH ANTICONVULSANT DRUGS.
Topics: Amphetamine; Amphetamines; Animals; Anticonvulsants; Electricity; Electroshock; Epilepsy; Epilepsy, | 1964 |
CHRONIC STEREOTACTIC IMPLANTATION OF DEPTH ELECTRODES FOR PSYCHOMOTOR EPILEPSY.
Topics: Brain; Electric Stimulation; Electrodes; Electroencephalography; Electrophysiology; Epilepsy; Epilep | 1964 |
EFFECTS OF BRAINSTEM AND SUBCORTICAL LESIONS ON CORTICOGENIC EPILEPTIC CONVULSION WITH SPECIAL REFERENCE TO FOREL H-FIELD.
Topics: Brain Diseases; Brain Stem; Cats; Cerebral Cortex; Electroencephalography; Electromyography; Epileps | 1964 |
MEASUREMENT OF ELECTRICAL IMPEDANCE IN THE HUMAN BRAIN: SOME PRELIMINARY OBSERVATIONS.
Topics: Amygdala; Brain; Carotid Arteries; Caudate Nucleus; Cerebrovascular Circulation; Electric Impedance; | 1964 |
[THE CLINICAL SIGNIFICANCE OF CARDIAZOL-ACTIVATED ELECTROENCEPHALOGRAPHY].
Topics: Adolescent; Cerebellar Diseases; Child; Craniocerebral Trauma; Electroencephalography; Epilepsy; Hum | 1964 |
EFFECTS OF CORTICAL SPREADING DEPRESSION AND DRUGS UPON AUDIOGENIC SEIZURES IN RATS.
Topics: Brain; Cerebral Cortex; Cortical Spreading Depression; Electrophysiology; Epilepsy; Epilepsy, Reflex | 1965 |
EPILEPTOGENIC PROPERTIES OF SUBCORTICAL FREEZING.
Topics: Animals; Basal Ganglia; Cats; Cryosurgery; Electroencephalography; Epilepsy; Freezing; Ganglia; Path | 1965 |
Metrazol and combined photic-metrazol activated electroencephalography in epileptic, schizophrenic, psychoneurotic, and psychopathic patients.
Topics: Electroencephalography; Epilepsy; Humans; Light; Mental Disorders; Pentylenetetrazole | 1955 |
Dynamic release of amino acid transmitters induced by valproate in PTZ-kindled epileptic rat hippocampus.
Topics: Amino Acid Transport Systems; Amino Acids; Animals; Anticonvulsants; Epilepsy; Hippocampus; Kindling | 2004 |
Anticonvulsant efficiency, behavioral performance and cortisol levels: a comparison of carbamazepine (CBZ) and a fatty acid compound (SR-3).
Topics: alpha-Linolenic Acid; Analysis of Variance; Animals; Anticonvulsants; Carbamazepine; Disease Models, | 2004 |
Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Dehydroepiandrosterone Sulfate; Diazepam; Dose-R | 2004 |
A perfused rat brain model maintaining the connection between the central and peripheral nervous systems.
Topics: Animals; Artificial Organs; Blood Pressure; Brain; Carotid Artery, Common; Central Nervous System; C | 2004 |
Experiences with combined stroboscopic and metrazol activation of the EEG in epileptics and in patients suspected of having seizures (Gastaut technique).
Topics: Electroencephalography; Epilepsy; Humans; Pentylenetetrazole; Seizures; Stroboscopy | 1950 |
Use of metrazol and the hydration pitressin test.
Topics: Epilepsy; Humans; Pentylenetetrazole; Pituitary Hormones; Vasopressins | 1950 |
Comparative effectiveness of sleep and metrazol-activated electroencephalography.
Topics: Electroencephalography; Epilepsy; Humans; Pentylenetetrazole; Sleep | 1951 |
[Peroral medication of cardiazol as a test for epilepsy; investigations on epileptics under EEG control].
Topics: Electroencephalography; Epilepsy; Humans; Pentylenetetrazole | 1951 |
Effect of harmane on the convulsive threshold in epilepsy models in mice.
Topics: Animals; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; Female; Harmine; Male; Mice; P | 2003 |
Thiol redox state (TRS) and oxidative stress in the mouse hippocampus after pentylenetetrazol-induced epileptic seizure.
Topics: Animals; Epilepsy; Hippocampus; Male; Mice; Mice, Inbred BALB C; Oxidation-Reduction; Oxidative Stre | 2004 |
Increased seizure threshold in mice lacking aquaporin-4 water channels.
Topics: Action Potentials; Animals; Aquaporin 4; Aquaporins; Brain; Brain Edema; Convulsants; Disease Models | 2004 |
Parvalbumin deficiency affects network properties resulting in increased susceptibility to epileptic seizures.
Topics: Action Potentials; Animals; Brain; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Geneti | 2004 |
Effect of single injection of pentylenetetrazole in a subconvulsive dose on Cl- conductance of the GABAA-receptor complex.
Topics: Animals; Cerebral Cortex; Chloride Channels; Chlorides; Convulsants; Electric Conductivity; Epilepsy | 2004 |
Pentylenetetrazole kindling induces activation of caspase-3 in the rat brain.
Topics: Analysis of Variance; Animals; Brain; Caspase 3; Caspases; Cell Death; Cerebellum; Cerebral Cortex; | 2004 |
MAO(A) knockout mice are more susceptible to seizures but show reduced epileptogenesis.
Topics: Animals; Electric Stimulation; Epilepsy; Female; Kindling, Neurologic; Male; Mice; Mice, Inbred C3H; | 2004 |
Evidence of the antiepileptic potential of amiloride with neuropharmacological benefits in rodent models of epilepsy and behavior.
Topics: Amiloride; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Rel | 2004 |
[Mechanisms of the effect of brain histamine on chronic epilepsy induced by pentylenetetrazole].
Topics: Animals; Brain; Chronic Disease; Dose-Response Relationship, Drug; Epilepsy; Histamine; Histidine; I | 2004 |
[Influence of chronic epilepsy on spatial memory retrieval in rats].
Topics: Animals; Benzazepines; Chronic Disease; Dose-Response Relationship, Drug; Epilepsy; Male; Maze Learn | 2004 |
Intranasal administration of human IL-6 increases the severity of chemically induced seizures in rats.
Topics: Administration, Intranasal; Animals; Convulsants; Enzyme-Linked Immunosorbent Assay; Epilepsy; Front | 2004 |
Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans.
Topics: Alleles; Amino Acid Sequence; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Codo | 2004 |
Pacemaker potentials are the physiologic basis of epileptiform activity in the buccal ganglia of Helix pomatia.
Topics: Action Potentials; Animals; Biological Clocks; Cheek; Convulsants; Electrodes; Electrophysiology; Ep | 2004 |
Continuous increase of epileptogenic effects following application of proteolytic enzymes (buccal ganglia of Helix pomatia).
Topics: Animals; Biological Clocks; Cheek; Convulsants; Disease Models, Animal; Enzymes; Epilepsy; Ganglia, | 2004 |
Vinpocetine inhibits the epileptic cortical activity and auditory alterations induced by pentylenetetrazole in the guinea pig in vivo.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Convulsants; Electroencephalography; Epilepsy; Evoked Pot | 2004 |
Seizure susceptibility to various convulsant stimuli in dystrophin-deficient mdx mice.
Topics: Acute Disease; Animals; Chronic Disease; Convulsants; Disease Models, Animal; Dystrophin; Epilepsy; | 2004 |
Measurement of cortical and hippocampal epileptiform activity in freely moving rats by means of implantable radiotelemetry.
Topics: Animals; Body Temperature; Cerebral Cortex; Electrodes, Implanted; Electroencephalography; Electromy | 2004 |
Genetic and phenotypic analysis of seizure susceptibility in PL/J mice.
Topics: Animals; Convulsants; Crosses, Genetic; Disease Models, Animal; Electroencephalography; Electroshock | 2004 |
Metrazol and electric stimulation as diagnostic aids in epilepsy.
Topics: Electric Stimulation; Epilepsy; Humans; Pentylenetetrazole | 1950 |
Electric current and metrazol as aids in the diagnosis of epilepsy.
Topics: Acquired Immunodeficiency Syndrome; Electricity; Electroencephalography; Epilepsy; Humans; Pentylene | 1950 |
Sleep metrazol, and auditory stimulation technics in electroencephalography.
Topics: Acoustic Stimulation; Electroencephalography; Epilepsy; Humans; Pentylenetetrazole | 1950 |
Down-regulation of dopamine D1 and D2 receptors in the basal ganglia of PTZ kindling model of epilepsy: effects of angiotensin IV.
Topics: Angiotensin II; Animals; Basal Ganglia; Dopamine D2 Receptor Antagonists; Down-Regulation; Epilepsy; | 2004 |
Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures.
Topics: Animals; Anticonvulsants; Bromides; Chronic Disease; Disease Models, Animal; Dog Diseases; Dogs; Dru | 2004 |
Role of muscarinic and nicotinic cholinergic receptors in an experimental model of epilepsy-induced analgesia.
Topics: Animals; Atropine; Chlorides; Convulsants; Epilepsy; GABA Antagonists; Male; Mecamylamine; Muscarini | 2004 |
Effect of pentylenetetrazol-induced epileptic seizure on thiol redox state in the mouse cerebral cortex.
Topics: Animals; Cerebral Cortex; Convulsants; Disulfides; Epilepsy; Lipid Peroxidation; Male; Mice; Mice, I | 2004 |
First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2.
Topics: Acoustic Stimulation; Acyltransferases; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Cells, | 2005 |
Ketogenic diet fed rats have low levels of S100B in cerebrospinal fluid.
Topics: Animals; Astrocytes; Biomarkers; Brain; Convulsants; Disease Models, Animal; Down-Regulation; Epilep | 2004 |
Anti-epileptogenic effect of beta-carotene and vitamin A in pentylenetetrazole-kindling model of epilepsy in mice.
Topics: Animals; Anticonvulsants; beta Carotene; Disease Models, Animal; Dose-Response Relationship, Drug; D | 2005 |
Proteomic identification of the involvement of the mitochondrial rieske protein in epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Electron Transport Complex III; Electrophoresis, Gel | 2005 |
Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats.
Topics: Animals; Anticonvulsants; Benzoquinones; Convulsants; Diazepam; Epilepsy; Flumazenil; Injections, In | 2005 |
Study of antiepileptic effect of extracts from Acorus tatarinowii Schott.
Topics: Acorus; Animals; Anticonvulsants; Brain; Disease Models, Animal; Electroshock; Epilepsy; gamma-Amino | 2005 |
Pharmacological properties of N-095, a drug containing red ginseng, polygala root, saffron, antelope horn and aloe wood.
Topics: Animals; Behavior, Animal; Carrageenan; Convulsants; Crocus; Drugs, Chinese Herbal; Edema; Epilepsy; | 2005 |
Bilateral, vascular and perivascular glial upregulation of heat shock protein-27 after repeated epileptic seizures.
Topics: Animals; Astrocytes; Blotting, Western; Brain; Convulsants; Disease Models, Animal; Electroencephalo | 2005 |
Epileptogenic insult causes a shift in the form of long-term potentiation expression.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Calcium Channels; Convulsants; Dizocilpine Malea | 2005 |
Pentylenetetrazol-induced seizures affect the levels of prolyl oligopeptidase, thimet oligopeptidase and glial proteins in rat brain regions, and attenuation by MK-801 pretreatment.
Topics: Animals; Brain; CD11b Antigen; Cerebral Cortex; Convulsants; Disease Models, Animal; Dizocilpine Mal | 2005 |
Thiol redox state and lipid and protein oxidation in the mouse striatum after pentylenetetrazol-induced epileptic seizure.
Topics: Animals; Corpus Striatum; Cysteine; Disease Models, Animal; Disulfides; Epilepsy; Glutathione; Lipid | 2005 |
Anticonvulsant effects of 1,25-dihydroxyvitamin D in chemically induced seizures in mice.
Topics: Animals; Anticonvulsants; Brain; Calcitriol; Convulsants; Disease Models, Animal; Epilepsy; Injectio | 2005 |
Preclinical profiling and safety studies of ABT-769: a compound with potential for broad-spectrum antiepileptic activity.
Topics: Abnormalities, Drug-Induced; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Disease Models, A | 2005 |
Block of spontaneous termination of paroxysmal depolarizations by forskolin (buccal ganglia, Helix pomatia).
Topics: Action Potentials; Animals; Colforsin; Drug Interactions; Electric Stimulation; Epilepsy; Ganglia, I | 2006 |
Effects of the fruit essential oil of Cuminum cyminum Linn. (Apiaceae) on pentylenetetrazol-induced epileptiform activity in F1 neurones of Helix aspersa.
Topics: Action Potentials; Animals; Cuminum; Epilepsy; Fruit; Helix, Snails; Neurons; Oils, Volatile; Pentyl | 2006 |
Effect of acute versus chronic theophylline administration on acute restraint stress-induced increase of pentylenetetrazol seizure threshold in mice.
Topics: Acute Disease; Animals; Anticonvulsants; Chronic Disease; Convulsants; Dose-Response Relationship, D | 2006 |
[Effect of saikosaponins on epileptic seizure and EEG in pentetrazole-induced chronic kindling rats].
Topics: Animals; Anticonvulsants; Electroencephalography; Epilepsy; Female; Kindling, Neurologic; Male; Olea | 2006 |
The utility of testing pentylenetetrazol threshold.
Topics: Age Factors; Animals; Body Weight; Brain; Convulsants; Diet Therapy; Disease Models, Animal; Epileps | 2006 |
Repeated brief epileptic seizures by pentylenetetrazole cause neurodegeneration and promote neurogenesis in discrete brain regions of freely moving adult rats.
Topics: Animals; Brain; Cell Proliferation; Convulsants; Disease Models, Animal; Epilepsy; Female; GABA Anta | 2006 |
Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: involvement of GABAergic and opioids systems.
Topics: Animals; Anticonvulsants; Cerebral Ventricles; Crocus; Cyclohexenes; Dose-Response Relationship, Dru | 2007 |
Effects of tianeptine on onset time of pentylenetetrazole-induced seizures in mice: possible role of adenosine A1 receptors.
Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Antidep | 2007 |
Additive effects of antiepileptic drugs and pentylenetetrazole on hearing.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Auditory Threshold; Convulsants; Disease Models, Ani | 2006 |
Epileptogenic drugs in a model nervous system: electrophysiological effects and incorporation into a phospholipid layer.
Topics: Action Potentials; Animals; Convulsants; Disease Models, Animal; Electric Stimulation; Epilepsy; Eto | 2006 |
[Effects of endogenous histamine on memory impairment induced by pentylenetetrazole-kindled epilepsy in rats].
Topics: Animals; Epilepsy; Hippocampus; Histamine; Kindling, Neurologic; Male; Memory Disorders; Neurons; Pe | 2006 |
Pentylenetetrazole kindling affects sleep in rats.
Topics: Animals; Behavior, Animal; Convulsants; Disease Models, Animal; Dizocilpine Maleate; Electromyograph | 2006 |
Isobolographic characterization of interactions between vigabatrin and tiagabine in two experimental models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interaction | 2007 |
Synthesis of 8-alkoxy-4,5-dihydro-[1,2,4]triazole[4,3-a]quinoline-1-ones and evaluation of their anticonvulsant properties.
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Epilepsy; Female; Indicators and Reagents; Magn | 2006 |
Correlation between provoked ictal SPECT and depth recordings in adult drug-resistant epilepsy patients.
Topics: Adult; Brain Mapping; Cerebral Cortex; Drug Resistance; Electrodes, Implanted; Electroencephalograph | 2007 |
Sex differences in modulating blood brain barrier permeability by NO in pentylenetetrazol-induced epileptic seizures.
Topics: Animals; Blood-Brain Barrier; Brain; Capillary Permeability; Convulsants; Disease Models, Animal; Dr | 2007 |
Dissociation between in vitro and in vivo epileptogenicity in a rat model of cortical dysplasia.
Topics: Animals; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy; Freezing; | 2007 |
Deep brain stimulation of the posterior hypothalamus activates the histaminergic system to exert antiepileptic effect in rat pentylenetetrazol model.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Convulsants; Cortical Synchronization; Deep Brain Stimul | 2007 |
Cl- conduction of GABA(A) receptor complex on synaptic membranes in rat cortex at the early stage of chronic cerebral epileptization.
Topics: Animals; Cerebral Cortex; Chlorides; Convulsants; Epilepsy; Male; Pentylenetetrazole; Rats; Rats, Wi | 2006 |
The anticonvulsant activity of acetone, the major ketone body in the ketogenic diet, is not dependent on its metabolites acetol, 1,2-propanediol, methylglyoxal, or pyruvic acid.
Topics: Acetone; Animals; Anticonvulsants; Diet Therapy; Disease Models, Animal; Epilepsy; Ketone Bodies; Ma | 2007 |
Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy.
Topics: Acetamides; Animals; Anticonvulsants; Bicuculline; Cobalt; Convulsants; Electroshock; Epilepsies, Pa | 2007 |
Zebrafish offer the potential for a primary screen to identify a wide variety of potential anticonvulsants.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug | 2007 |
Modified variant of the Rieske iron-sulfur protein in the hippocampus of kindled rats and human epileptic patients.
Topics: Animals; Electron Transport Complex III; Epilepsy; Hippocampus; Humans; Iron-Sulfur Proteins; Kindli | 2007 |
Timed pentylenetetrazol infusion test: a comparative analysis with s.c.PTZ and MES models of anticonvulsant screening in mice.
Topics: Animals; Anticonvulsants; Convulsants; Data Interpretation, Statistical; Drug Evaluation, Preclinica | 2007 |
[Effect of saikosaponin alpha on experimental epilepsy in rats].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Epilepsy; Female; Male; Oleanolic | 2007 |
Neuroprotective effect of nimesulide, a preferential COX-2 inhibitor, against pentylenetetrazol (PTZ)-induced chemical kindling and associated biochemical parameters in mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Chemistry; Cyclooxygenase Inhibitors; Disease | 2007 |
Modafinil exerts a dose-dependent antiepileptic effect mediated by adrenergic alpha1 and histaminergic H1 receptors in mice.
Topics: Animals; Benzhydryl Compounds; Disease Models, Animal; Electroencephalography; Electroshock; Epileps | 2007 |
Increased P-glycoprotein expression and decreased phenobarbital distribution in the brain of pentylenetetrazole-kindled rats.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Brain; Brain Ch | 2007 |
Electroencephalographic activation with methohexital in an epileptic population.
Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Convulsants; Electroencephalography; Epilepsy; Fe | 1974 |
Total brain tissue sialic acid levels due to glutathione effect in experimental epilepsy.
Topics: Animals; Brain; Convulsants; Dose-Response Relationship, Drug; Epilepsy; Female; Glutathione; Male; | 2007 |
[Effect of carbenoxolone on expression of Fos, NMDAR2 and GFAP in the hippocampus of pentylenetetrazo-kindled epileptic rats].
Topics: Animals; Carbenoxolone; Epilepsy; Gap Junctions; Glial Fibrillary Acidic Protein; Hippocampus; Immun | 2007 |
Calorie-restricted ketogenic diet increases thresholds to all patterns of pentylenetetrazol-induced seizures: critical importance of electroclinical assessment.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Body Weight; Caloric Restriction; Cerebral Cortex; Di | 2008 |
[Influence of repeated seizures and large dosage anti-epileptic drug on phosphorylated cAMP response element binding protein in rat's hippocampus and effect of Caoguo Zhimu Decoction].
Topics: Animals; Cognition Disorders; Cyclic AMP Response Element-Binding Protein; Drugs, Chinese Herbal; Ep | 2007 |
The effect of progesterone on total brain tissue sialic acid levels in experimental epilepsy.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Epilepsy; Female; Kindling, Neurologic; Male; Mice | 2008 |
Activation of seizures and electroencephalographic disturbances in epileptic and in control subjects with metrazol.
Topics: Electroencephalography; Epilepsy; Humans; Pentylenetetrazole; Seizures | 1948 |
Timed intravenous infusion of metrazol and strychnine for testing anticonvulsant drugs.
Topics: Anticonvulsants; Epilepsy; Humans; Infusions, Intravenous; Pentylenetetrazole; Seizures; Strychnine | 1949 |
[Changes of mossy fiber sprouting in hippocampus of pentylenetetrazole kindling rats].
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Mossy Fibers, Hi | 2007 |
Sedative and anticonvulsant effects of zolpidem in adult and aged mice.
Topics: Age Factors; Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Disease Models, Animal; Dose-Re | 2008 |
Effects of gamma-decanolactone on seizures induced by PTZ-kindling in mice.
Topics: Animals; Anticonvulsants; Brain; Comet Assay; Convulsants; Disease Models, Animal; DNA Damage; Dose- | 2008 |
Anticonvulsant characteristics of pyridoxyl-gamma-aminobutyrate, PL-GABA.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Drug Tolerance; Electrophysiology; | 2008 |
Antiepileptic effects of electroacupuncture vs vagus nerve stimulation on cortical epileptiform activities.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Dose-Respon | 2008 |
Glutamine synthetase becomes nitrated and its activity is reduced during repetitive seizure activity in the pentylentetrazole model of epilepsy.
Topics: Animals; Astrocytes; Brain; Disease Models, Animal; Epilepsy; Gene Expression Regulation; Glial Fibr | 2008 |
[Electroencephalographic study on epileptic seizure induced by metrazol injection, with special reference to the origin of the excitatory discharge].
Topics: Animals; Cats; Electroencephalography; Epilepsy; Injections, Intravenous; Pentylenetetrazole | 1966 |
Language-induced epilepsy.
Topics: Electroencephalography; Epilepsy; Ethosuximide; Humans; Male; Middle Aged; Movement Disorders; Penty | 1967 |
[Progressive myoclonus epilepsy with Lafora bodies. Clinical and polygraphic study. Anatomical ultrastructural verification].
Topics: Adolescent; Brain; Cytoplasmic Granules; Diazepam; Electrocardiography; Electroencephalography; Elec | 1967 |
Ionic and acid-base regulation of neurons and glia during seizures.
Topics: Acid-Base Equilibrium; Adenosine Triphosphatases; Animals; Anion Transport Proteins; Bicarbonates; C | 1984 |
Convulsant drugs: mechanisms of action.
Topics: Amino Acids; Barbiturates; Biological Transport, Active; Brain; Cholinesterase Inhibitors; Convulsan | 1980 |
A model of chronic spontaneous petit mal-like seizures in the rat: comparison with pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalo | 1984 |
Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy.
Topics: Animals; Anticonvulsants; Electroshock; Epilepsy; Fatty Acids, Monounsaturated; Fatty Acids, Unsatur | 1984 |
Effect of a single brief seizure on subsequent seizure susceptibility in the immature rat.
Topics: Animals; Disease Susceptibility; Electroshock; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy; | 1984 |
[EEG activation with bemegride in epilepsy diagnosis. 1: Literature review].
Topics: Adolescent; Adult; Anticonvulsants; Bemegride; Dose-Response Relationship, Drug; Electroencephalogra | 1984 |
The effect of spontaneous seizures on pentylenetetrazole and maximum electroshock induced seizures in the Mongolian gerbil.
Topics: Animals; Disease Models, Animal; Electroshock; Endorphins; Epilepsy; Female; Gerbillinae; Male; Mode | 1984 |
Neural mechanisms in cardiac arrhythmias associated with epileptogenic activity: the effect of phenobarbital in the cat.
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Blood Pressure; Cats; Disease Models, Anima | 1984 |
Specific gravity increases and brain water content decreases during short epileptiform seizures in discrete rabbit brain areas.
Topics: Animals; Bicuculline; Blood; Blood-Brain Barrier; Body Water; Brain; Epilepsy; Epinephrine; Hyperten | 1984 |
The evaluation of different types of anti-convulsant drug activity against leptazol-induced epileptogenic activity in the anaesthetized rat.
Topics: Anesthesia; Animals; Anticonvulsants; Electroencephalography; Epilepsy; Male; Pentylenetetrazole; Ra | 1983 |
Effect of epileptogenic agents on the incorporation of 3H-glycine into proteins in the cat's cerebral cortex.
Topics: Acoustic Stimulation; Aminopyridines; Animals; Cats; Cerebral Cortex; Convulsants; Cycloheximide; Ep | 1982 |
Relationship between GABA concentrations in cerebrospinal fluid and seizure excitability.
Topics: Animals; Dogs; Epilepsy; Female; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Seizures; Seizur | 1982 |
Aspects of the pentylenetetrazol kindling model of epileptogenesis in the rat.
Topics: Amino Acids; Animals; Brain Chemistry; Epilepsy; Kindling, Neurologic; Male; Models, Neurological; P | 1982 |
Increased nucleotide catabolism after cerebral convulsions.
Topics: Animals; Child; Epilepsy; Female; Humans; Hypoxanthines; Nucleotides; Pentylenetetrazole; Rabbits; S | 1981 |
Pharmacologic analysis of the postictal immobility syndrome in the rat.
Topics: Animals; Behavior, Animal; Electroencephalography; Electroshock; Epilepsy; Female; Haloperidol; Moto | 1981 |
The anticonvulsant effects of diazepam and phenobarbital in prekindled and kindled cortical seizures.
Topics: Amygdala; Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Disease Models, Animal; Epilepsy; Mal | 1981 |
[The value of pentetrazol (Deumacard) provocation in EEG for the evaluation of driving ability].
Topics: Automobile Driving; Electroencephalography; Epilepsy; Evoked Potentials; Humans; Pentylenetetrazole; | 1981 |
Kindling induces long-lasting alterations in response of hippocampal neurons to elevated potassium levels in vitro.
Topics: Animals; Dose-Response Relationship, Drug; Epilepsy; Guinea Pigs; Hippocampus; In Vitro Techniques; | 1980 |
Antiepileptic effects of inhibitors of nitric oxide synthase examined in pentylenetetrazol-induced seizures in rats.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Calmodulin-Binding Proteins; Epilepsy; Male; NG-Nitro | 1994 |
Decrease and increase of responses to glutamate receptor agonists in RNA-injected Xenopus oocytes by the epileptogenic agent pentylenetetrazol: dependence on the agonist concentration.
Topics: Animals; Epilepsy; Excitatory Amino Acid Agonists; Female; Injections; Oocytes; Osmolar Concentratio | 1994 |
Clinical signs of ivermectin toxicity and the efficacy of antigabaergic convulsants as antidotes for ivermectin poisoning in epileptic chickens.
Topics: Animals; Antidotes; Carbolines; Chickens; Epilepsy; GABA Antagonists; Ivermectin; Pentylenetetrazole | 1995 |
Distribution of unsaturated metabolites of valproate in human and rat brain--pharmacologic relevance?
Topics: Adolescent; Adult; Aged; Animals; Biological Transport; Blood-Brain Barrier; Brain; Brain Chemistry; | 1995 |
An evaluation of the epileptogenic properties of a rifampicin/clindamycin-impregnated shunt catheter.
Topics: Animals; Clindamycin; Epilepsy; Hydrocephalus; Male; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; | 1994 |
[Increase in sensitivity of mice to a convulsant after adoptive transfer of splenocytes from mice, subjected to corazole kindling].
Topics: Animals; Cell Transplantation; Convulsants; Disease Models, Animal; Epilepsy; Immunotherapy, Adoptiv | 1995 |
Potassium currents in epilepsy: effects of the epileptogenic agent pentylenetetrazol on a cloned potassium channel.
Topics: Animals; Cloning, Molecular; Electrophysiology; Epilepsy; Membrane Potentials; Oocytes; Patch-Clamp | 1994 |
Dexmedetomidine decreases seizure threshold in a rat model of experimental generalized epilepsy.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Disease Models, Animal; Dose-Respo | 1994 |
Pentylenetetrazol elicits epileptiform activity in the dentate gyrus of the urethane anesthetized rat by activation of the entorhinal cortex.
Topics: Anesthesia; Animals; Cerebral Cortex; Electric Stimulation; Epilepsy; Hippocampus; Male; Neurons, Ef | 1994 |
Kainic acid, bicuculline, pentylenetetrazol and pilocarpine elicit maximal dentate activation in the anesthetized rat.
Topics: Anesthesia; Animals; Bicuculline; Convulsants; Electric Stimulation; Epilepsy; Evoked Potentials; Hi | 1994 |
Morphology of CA3 neurons in hippocampal slices with nonepileptic and epileptic activity: a light and electron microscopic study.
Topics: Animals; Epilepsy; Guinea Pigs; Hippocampus; Horseradish Peroxidase; In Vitro Techniques; Membrane P | 1993 |
[Development of pentylenetetrazol kindling model].
Topics: Animals; Disease Models, Animal; Epilepsy; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rat | 1993 |
Antiepileptic effect of antiepilepsirine in pentylenetetrazol and amygdala kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Epilepsy; Kindling, Neurologic; Male; Pentylenetetrazole; Piperi | 1993 |
Intermittent clonazepam treatment prevents anticonvulsant tolerance in mice.
Topics: Animals; Clonazepam; Disease Models, Animal; Drug Administration Schedule; Drug Tolerance; Epilepsy; | 1993 |
GABA-responses of CA3 neurones at epileptogenic threshold concentrations of convulsants.
Topics: Action Potentials; Animals; Bicarbonates; Bicuculline; Caffeine; Chlorides; Convulsants; Epilepsy; g | 1993 |
Behavioural and electroencephalographic effects of Tityus serrulatus scorpion venom in rats.
Topics: Animals; Behavior, Animal; Convulsants; Dose-Response Relationship, Drug; Electrodes; Electroencepha | 1993 |
Reduced incidence of cortical spreading depression in the course of pentylenetetrazol kindling in rats.
Topics: Animals; Cortical Spreading Depression; Electric Stimulation; Epilepsy; Incidence; Kindling, Neurolo | 1993 |
Regulation of brain-derived neurotrophic factor messenger RNA and protein at the cellular level in pentylenetetrazol-induced epileptic seizures.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Epi | 1993 |
Epileptic discharges induced by pentylenetetrazol: ultrastructural alterations in identified neurons and glial cells (Helix pomatia).
Topics: Animals; Cell Nucleolus; Cell Size; Cytoplasmic Granules; Epilepsy; Ganglia, Invertebrate; Helix, Sn | 1995 |
Failure of chronic treatment with abecarnil to induce contigent and noncontingent tolerance in pentylenetetrazol-kindled rats.
Topics: Animals; Anticonvulsants; Carbolines; Drug Tolerance; Epilepsy; Injections, Intraperitoneal; Kindlin | 1996 |
Effects of an ethanolic extract of Desmodium adscendens on central nervous system in rodents.
Topics: Acetates; Acetic Acid; Analgesics; Analysis of Variance; Animals; Anticonvulsants; Body Temperature; | 1996 |
Peripheral-type benzodiazepine receptors in association with epileptic seizures in EL mice.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Binding Sites; Cell Fractionation; Convulsants; Epi | 1996 |
Effect of seizures on cerebral blood flow measured with 15O-H2O and positron emission tomography.
Topics: Adult; Cerebrovascular Circulation; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, | 1996 |
Alterations of neuronal fibers after epileptic activity induced by pentylenetetrazole: fine structure investigated by calcium cytochemistry and neurobiotin labeling (buccal ganglia, Helix pomatia).
Topics: Animals; Biotin; Calcium; Cheek; Dendrites; Disease Models, Animal; Electrophysiology; Epilepsy; Gan | 1996 |
Anticonvulsant effect of felbamate in the pentylenetetrazole kindling model of epilepsy in the rat.
Topics: Animals; Anticonvulsants; Epilepsy; Felbamate; Kindling, Neurologic; Male; Pentylenetetrazole; Pheny | 1996 |
The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. VI. Seasonal influences on maximal electroshock and pentylenetetrazol seizure thresholds.
Topics: Animals; Anticonvulsants; Circadian Rhythm; Disease Models, Animal; Electroshock; Epilepsy; Male; Mi | 1996 |
Simultaneous blockade of intracellular calcium increases and of neuronal epileptiform depolarizations by verapamil.
Topics: Animals; Calcium; Calcium Channel Blockers; Electrophysiology; Epilepsy; Helix, Snails; Intracellula | 1996 |
A method to study the effects of an epileptic focus on non-epileptic nervous tissue.
Topics: Animals; Epilepsy; Ganglia, Invertebrate; Pentylenetetrazole; Research Design | 1996 |
Diversity of potassium channels contributing to differences in brain area-specific seizure susceptibility: sensitivity of different potassium channels to the epileptogenic agent pentylenetetrazol.
Topics: Animals; Brain Mapping; Cerebellum; Cerebral Cortex; Disease Susceptibility; Epilepsy; Hippocampus; | 1997 |
Diazepam--its effects on the development of pentylenetetrazol kindling, related learning impairments, and neuronal cell loss.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cell Count; Convulsants; Diazepam; | 1997 |
Sensitivity to jerky gene dosage underlies epileptic seizures in mice.
Topics: Aging; Alleles; Amino Acid Sequence; Animals; Brain; Cerebral Cortex; Disease Susceptibility; DNA Pr | 1997 |
Glutamate transporter EAAC-1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration.
Topics: Amino Acid Sequence; Amino Acid Transport System X-AG; Amino Acids, Dicarboxylic; Animals; Brain; Ca | 1997 |
Anticonvulsant effect of anterior thalamic high frequency electrical stimulation in the rat.
Topics: Animals; Convulsants; Electric Stimulation; Electroencephalography; Epilepsy; Male; Pentylenetetrazo | 1997 |
Strain differences in pentylenetetrazol-kindling development and subsequent potentiation effects.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy; Glutamic Acid; Kindling, Neurologic; Male; P | 1997 |
Fos in locus coeruleus neurons following audiogenic seizure in the genetically epilepsy-prone rat: comparison to electroshock and pentylenetetrazol seizure models.
Topics: Animals; Disease Models, Animal; Electroshock; Epilepsy; Female; Locus Coeruleus; Pentylenetetrazole | 1997 |
Brain cortex Na(+)-K+ ATPase activities in streptozotocin-diabetic and pentylenetetrazol-epileptic rats.
Topics: Animals; Cerebral Cortex; Convulsants; Diabetes Mellitus, Experimental; Epilepsy; Pentylenetetrazole | 1997 |
Increased expression of microtubule-associated protein 1B in the hippocampus, subiculum, and perforant path of rats treated with a high dose of pentylenetetrazole.
Topics: Animals; Biomarkers; Blotting, Northern; Blotting, Western; Convulsants; Dentate Gyrus; Epilepsy; Fe | 1997 |
Epileptic neurons induce augmenting synaptic depolarizations in non-epileptic neurons (buccal ganglia, Helix pomatia).
Topics: Animals; Cell Membrane; Convulsants; Electrophysiology; Epilepsy; Ganglia, Invertebrate; Helix, Snai | 1997 |
Altered expression of microtubule-associated protein 1B in cerebral cortical structures of pentylenetetrazole-treated rats.
Topics: Animals; Blotting, Northern; Blotting, Western; Convulsants; Entorhinal Cortex; Epilepsy; Female; Ge | 1998 |
Pentylenetetrazole (PTZ)-induced c-fos expression in the hippocampus of kindled rats is suppressed by concomitant treatment with naloxone.
Topics: Amygdala; Animals; Convulsants; Dentate Gyrus; Epilepsy; Gene Expression; Gyrus Cinguli; In Situ Hyb | 1998 |
Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbolines; Convulsants; Diazepam; Disease Mod | 1998 |
[Effect of cerebral ischemia of various severity on acute seizures and chronic epileptogenesis].
Topics: Acute Disease; Animals; Arterial Occlusive Diseases; Brain Ischemia; Carotid Artery Diseases; Chroni | 1998 |
Effects of new valproate derivatives on epileptiform discharges induced by pentylenetetrazole or low Mg2+ in rat entorhinal cortex-hippocampus slices.
Topics: Animals; Anticonvulsants; Convulsants; Entorhinal Cortex; Epilepsy; Female; Glucose; Hippocampus; In | 1998 |
Effects of GABAB receptor antagonism on the development of pentylenetetrazol-induced kindling in mice.
Topics: Animals; Avoidance Learning; Behavior, Animal; Benzoates; Convulsants; Epilepsy; GABA Antagonists; G | 1998 |
A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat.
Topics: 3-Hydroxybutyric Acid; Animals; Dietary Carbohydrates; Dietary Fats; Disease Models, Animal; Epileps | 1999 |
Effects of some AMPA receptor antagonists on the development of tolerance in epilepsy-prone rats and in pentylenetetrazole kindled rats.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Convulsants; Dose-Response Relationship, Drug; Drug Adm | 1999 |
Heptanol exerts epileptiform effects in identified neurons of the buccal ganglia of Helix pomatia.
Topics: Animals; Cheek; Dose-Response Relationship, Drug; Drug Synergism; Electric Conductivity; Epilepsy; G | 1999 |
Blocking of the axon spikes by pentylenetetrazol in an identified neuron of the snail Helix lucorum, with consequent induction of epileptic activity in the cell body of the same neuron.
Topics: Action Potentials; Animals; Axons; Convulsants; Epilepsy; Helix, Snails; Nerve Block; Neurons; Penty | 1999 |
Reversal by flunarizine of the decrease in hippocampal acetylcholine release in pentylenetetrazole-kindled rats.
Topics: Acetylcholine; Analysis of Variance; Animals; Anticonvulsants; Calcium; Convulsants; Disease Models, | 1999 |
Electroencephalographic study of the effect of neurotoxin DSP-4 in iron model of chronic focal epilepsy.
Topics: Animals; Benzylamines; Cerebral Cortex; Chlorides; Electroencephalography; Epilepsy; Ferric Compound | 1999 |
Polyunsaturated fatty acids modify mouse hippocampal neuronal excitability during excitotoxic or convulsant stimulation.
Topics: Action Potentials; Animals; Convulsants; Docosahexaenoic Acids; Eicosapentaenoic Acid; Epilepsy; Fat | 1999 |
Upregulation of NMDA receptors in hippocampus and cortex in the pentylenetetrazol-induced "kindling" model of epilepsy.
Topics: Animals; Autoradiography; Dentate Gyrus; Dizocilpine Maleate; Epilepsy; Glutamic Acid; Hippocampus; | 1999 |
Increased sensitivity to seizures in mice lacking cellular prion protein.
Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Kindling, Neurologic; Male; Mice; Mice, Knoc | 1999 |
A major effect QTL determined by multiple genes in epileptic EL mice.
Topics: Alleles; Animals; Disease Models, Animal; Epilepsy; Female; Genetic Markers; Homozygote; Male; Mice; | 2000 |
Gene mapping of SEZ group genes and determination of pentylenetetrazol susceptible quantitative trait loci in the mouse chromosome.
Topics: Animals; Chromosome Mapping; Chromosomes; Epilepsy; Humans; Mice; Mice, Inbred Strains; Pentylenetet | 2000 |
Novel role for the NMDA receptor redox modulatory site in the pathophysiology of seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Chemotactic Factors; Convulsants; Dithionitrobenzoic Acid; Ep | 2000 |
Long-lasting effects of GABA infusion into the cerebral cortex of the rat.
Topics: Animals; Anisomycin; Cerebral Cortex; Convulsants; Electric Stimulation; Epilepsy; gamma-Aminobutyri | 2000 |
Relationship between large conductance calcium-activated potassium channel and bursting activity.
Topics: Action Potentials; Animals; Apamin; Caffeine; Calcium; Cells, Cultured; Cerebral Cortex; Epilepsy; I | 2000 |
Role of nitric oxide in pentylenetetrazol-induced seizures: age-dependent effects in the immature rat.
Topics: Age Factors; Animals; Animals, Newborn; Arginine; Brain; Catalysis; Disease Models, Animal; Electroe | 2000 |
A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat.
Topics: Acoustic Stimulation; Alprazolam; Animals; Anti-Anxiety Agents; Cognition; Conflict, Psychological; | 2000 |
Repeated long-term potentiation induces mossy fibre sprouting and changes the sensibility of hippocampal granule cells to subconvulsive doses of pentylenetetrazol.
Topics: Action Potentials; Animals; Convulsants; Electric Stimulation; Electrodes, Implanted; Epilepsy; Evok | 2000 |
The importance of free hydroxyl radicals to hypoxia preconditioning.
Topics: Animals; Brain; Convulsants; Epilepsy; Hydroxyl Radical; Hypoxia, Brain; Ischemic Preconditioning; M | 2000 |
GABA-transaminase antisense oligodeoxynucleotide modulates cocaine- and pentylenetetrazol-induced seizures in mice.
Topics: 4-Aminobutyrate Transaminase; Animals; Brain; Cerebral Ventricles; Cocaine; Convulsants; Dopamine Up | 1999 |
Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability.
Topics: Animals; Blotting, Southern; Brain; Catecholamines; Electroencephalography; Epilepsy; Epilepsy, Beni | 2000 |
The GABA-B antagonist CGP 36742 prevent PTZ-kindling-provoked amnesia in rats.
Topics: Amnesia; Animals; Avoidance Learning; Epilepsy; GABA Antagonists; Kindling, Neurologic; Male; Organo | 2000 |
Seizures and sensory stimulation result in different patterns of brain derived neurotrophic factor protein expression in the barrel cortex and hippocampus.
Topics: Animals; Brain-Derived Neurotrophic Factor; Convulsants; Epilepsy; Excitatory Amino Acid Agonists; G | 2000 |
Anticonvulsive activity of Albizzia lebbeck, Hibiscus rosa sinesis and Butea monosperma in experimental animals.
Topics: Amphetamine; Animals; Anticonvulsants; Behavior, Animal; Brain Chemistry; Central Nervous System Sti | 2000 |
Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Enzyme Inhibitors; Epilepsy | 2000 |
Effects of compounds acting on GABA(B) receptors in the pentylenetetrazole kindling model of epilepsy in mice.
Topics: Animals; Cerebral Cortex; Convulsants; Disease Models, Animal; Epilepsy; GABA Antagonists; GABA-B Re | 2000 |
Nitric oxide content measured by ESR-spectroscopy in the rat brain is increased during pentylenetetrazole-induced seizures.
Topics: Animals; Arginine; Brain; Convulsants; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Epil | 2000 |
Primed-burst potentiation occludes the potentiation phenomenon and enhances the epileptiform activity induced by transient pentylenetetrazol in the CA1 region of rat hippocampal slices.
Topics: Action Potentials; Animals; Axons; Electric Stimulation; Epilepsy; Hippocampus; Long-Term Potentiati | 2000 |
Plastic changes in neuropeptide Y receptor subtypes in experimental models of limbic seizures.
Topics: Animals; Anticonvulsants; Arginine; Blotting, Western; Electroencephalography; Epilepsy; Hippocampus | 2000 |
Seizures induce simultaneous GABAergic and glutamatergic transmission in the dentate gyrus-CA3 system.
Topics: Amygdala; Animals; Dentate Gyrus; Electric Stimulation; Electrodes, Implanted; Epilepsy; Evoked Pote | 2000 |
Long-term reduction of benzodiazepine receptor density in the rat cerebellum by acute seizures and kindling and its recovery 6 months later by a pentylenetetrazole challenge.
Topics: Acute Disease; Aging; Animals; Cerebellum; Convulsants; Diazepam; Drug Administration Schedule; Epil | 2001 |
[Effect of intraventricular infusion of Licvorin on general convulsive activity of rats].
Topics: Animals; Anticonvulsants; Cattle; Cerebrospinal Fluid; Epilepsy; GABA Antagonists; Injections, Intra | 2000 |
Neuropeptide Y and epilepsy: varying effects according to seizure type and receptor activation.
Topics: Animals; Anticonvulsants; Cells, Cultured; Epilepsy; Hippocampus; Male; Neuropeptide Y; Pentylenetet | 2001 |
Anticonvulsant properties and bio-guided isolation of palmitone from leaves of Annona diversifolia.
Topics: Animals; Anticonvulsants; Epilepsy; Hydrocarbons; Ketones; Male; Mice; Molecular Structure; Motor Ac | 2001 |
Sex-dependent changes in blood-brain barrier permeability in epileptic rats following acute hyperosmotic exposure.
Topics: Animals; Blood-Brain Barrier; Convulsants; Epilepsy; Female; Male; Osmolar Concentration; Pentylenet | 2001 |
Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepinones; Desoxycorticosterone; Diazepam; | 2001 |
Neurosteroid withdrawal model of perimenstrual catamenial epilepsy.
Topics: 20-alpha-Dihydroprogesterone; Adult; Animals; Behavior, Animal; Disease Models, Animal; Disease Susc | 2001 |
Anticonvulsant profile of valrocemide (TV1901): a new antiepileptic drug.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Respo | 2001 |
3alpha,5alpha-THP in the raphe magnus attenuates PTZ-induced myoclonic seizures.
Topics: Animals; Cerebral Cortex; Electroencephalography; Epilepsies, Myoclonic; Epilepsy; Estrus; Female; G | 2001 |
Histamine and selective H3-receptor ligands: a possible role in the mechanism and management of epilepsy.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Drug Synergism; Epilepsy; Histamine; Histamine Agonist | 2001 |
Testosterone reduces pentylenetetrazole-induced ictal activity of wildtype mice but not those deficient in type I 5alpha-reductase.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Animals; Brain; Convulsants; Epilepsy; Female; gamma-Aminobut | 2001 |
Effects of angiotensin III and angiotensin IV on pentylenetetrazol seizure susceptibility (threshold and kindling): interaction with adenosine A(1) receptors.
Topics: Adenosine; Angiotensin II; Angiotensin III; Angiotensins; Animals; Brain; Convulsants; Disease Susce | 2001 |
Influence of antioxidants on the blood-brain barrier permeability during epileptic seizures.
Topics: Albumins; Animals; Antioxidants; Blood-Brain Barrier; Brain; Coloring Agents; Convulsants; Endotheli | 2001 |
Stimulation of gene expression of NeuroD-related factor in the mouse brain following pentylenetetrazol-induced seizures.
Topics: Age Factors; Animals; Basic Helix-Loop-Helix Transcription Factors; Convulsants; Cycloheximide; Dizo | 2001 |
[Effect of caoguo zhimu decoction on N-methyl-D-aspartate receptor gene expression of epileptic kindling model in rats].
Topics: Animals; Drugs, Chinese Herbal; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Models, Neurologi | 1999 |
[Effect of tsaoko-anemarrhenae decoction on intracerebral c-fos, c-jun mRNA expression in interrupting pentylentetrazol kindled epileptic rat model].
Topics: Animals; Anticonvulsants; Brain; Drugs, Chinese Herbal; Epilepsy; Kindling, Neurologic; Male; Pentyl | 2000 |
The pentylenetetrazole-kindling model of epilepsy in SAMP8 mice: behavior and metabolism.
Topics: Aging; Amino Acids; Animals; Anticonvulsants; Behavior, Animal; Brain; Convulsants; Epilepsy; Excita | 2002 |
Nociceptin, OP4 receptor ligand in different models of experimental epilepsy.
Topics: Animals; Bicuculline; Disease Models, Animal; Electric Stimulation; Epilepsy; Female; Mice; N-Methyl | 2002 |
Anticonvulsant profile and teratogenicity of N-methyl-tetramethylcyclopropyl carboxamide: a new antiepileptic drug.
Topics: Acoustic Stimulation; Administration, Oral; Amides; Animals; Anticonvulsants; Behavior, Animal; Bicu | 2002 |
Effects of histidine, a precursor of histamine, on pentylenetetrazole-induced seizures in rats.
Topics: Animals; Drug Synergism; Epilepsy; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Histi | 2002 |
Effects of antisense glutamic acid decarboxylase oligodeoxynucleotide on epileptic rats induced by pentylenetetrazol.
Topics: Animals; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippoca | 2002 |
Hyperexcitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene.
Topics: Animals; Anticonvulsants; Chimera; Convulsants; Entorhinal Cortex; Epilepsy; Female; Heterozygote; H | 2002 |
Clobazam: anticonvulsant action in animal models of epilepsy [proceedings].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Electroshock; Epilepsy; Haplorhini; | 1979 |
[Pharmaco-cellular enzymology of the mechanism of action of stiripentol in cardiazol-induced epilepsy. II. Glucose metabolism].
Topics: Animals; Anticonvulsants; Brain; Brain Chemistry; Dioxolanes; Energy Metabolism; Epilepsy; Female; G | 1978 |
[Pharmaco-cellular enzymology of the mechanism of action of stiripentol in cardiazol-induced epilepsy. III. Protein, nucleoprotein, lipid, and proteoglycan metabolism].
Topics: 3-Hydroxyacyl CoA Dehydrogenases; 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Arylsulfat | 1978 |
[Psychotropic drugs in the clinical picture of epilepsy (review of the literature)].
Topics: Amitriptyline; Animals; Anti-Anxiety Agents; Anticonvulsants; Antipsychotic Agents; Carbamazepine; C | 1975 |
Reactivity patterns of nerve cell-glia-complexes in mice during pentylenetrazole-induced seizures. Cytometric-cytophotometric studies.
Topics: Animals; Brain; Capillaries; Epilepsy; Male; Mice; Motor Cortex; Motor Neurons; Neuroglia; Neurons; | 1978 |
Action of anticonvulsants on pentylenetetrazol-induced epileptiform activity on invertebrate neurones (Helix aspersa).
Topics: Action Potentials; Amobarbital; Animals; Anticonvulsants; Diazepam; Epilepsy; Helix, Snails; In Vitr | 1978 |
Combined activation of the EEG with brietal and pentetrazol.
Topics: Adult; Aged; Brain; Electroencephalography; Epilepsy; Female; Humans; Male; Methohexital; Middle Age | 1978 |
Role of the intracarotid amobarbital-pentylenetetrazol EEG test in the diagnosis and surgical treatment of patients with complex seizure problems.
Topics: Adolescent; Amobarbital; Brain; Carotid Arteries; Cerebrovascular Circulation; Depression, Chemical; | 1976 |
Changes in cerebral blood volume and vascular mean transit time during induced cerebral seizures.
Topics: Animals; Blood Pressure; Blood Volume; Brain; Carbon Dioxide; Carboxyhemoglobin; Cerebrovascular Cir | 1976 |
Brain function in epilepsy: midbrain, medullary, and cerebellar interaction with the rostral forebrain.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Cobalt; Disease Models, Animal; Electric Stimulation; E | 1976 |
Kindling-related changes in afterdischarge "thresholds".
Topics: Amygdala; Animals; Electric Stimulation; Electroencephalography; Epilepsy; Male; Pentylenetetrazole; | 1976 |
Biphasic action of imipramine in laboratory models of epilepsy.
Topics: Anesthesia; Animals; Behavior, Animal; Cats; Electroencephalography; Electroshock; Epilepsy; Estroge | 1976 |
Brain gangliosides in drug-induced status epilepticus.
Topics: Animals; Bemegride; Brain; Caudate Nucleus; Cerebral Cortex; Epilepsy; Gangliosides; Pentylenetetraz | 1975 |
Surgery of frontal lobe epilepsy.
Topics: Adolescent; Adult; Age Factors; Amobarbital; Birth Injuries; Brain Neoplasms; Carotid Arteries; Chil | 1975 |
Changes in regional blood flow and cardiodynamics associated with electrically and chemically induced epilepsy in cat.
Topics: Adrenalectomy; Animals; Atropine; Blood Pressure; Cardiac Output; Cats; Electric Stimulation; Electr | 1975 |
Four models for studying cerebral lesions secondary to epileptic seizures.
Topics: Animals; Astrocytes; Bicuculline; Blood Gas Analysis; Blood Glucose; Blood Pressure; Body Temperatur | 1975 |
Epileptiform seizures in domestic fowl. V. The anticonvulsant activity of delta9-tetrahydrocannabinol.
Topics: Animals; Anticonvulsants; Cannabis; Chickens; Dronabinol; Electroencephalography; Epilepsy; Female; | 1975 |
Chronic models of cortical epilepsy: experimental manipulations leading to long-term reorganization of local neocortical circuitry.
Topics: Animals; Cerebral Cortex; Culture Techniques; Epilepsy; Evoked Potentials; Kindling, Neurologic; Ner | 1992 |
Influence of phenobarbital on ECoG phenomena induced by metrazol in rats during ontogenesis.
Topics: Aging; Animals; Cerebral Cortex; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Dru | 1992 |
Epileptic activity as a tool in neurobiology.
Topics: Animals; Cell Size; Epilepsy; Helix, Snails; Models, Biological; Nerve Net; Neurobiology; Neurons; P | 1992 |
Effects of phenobarbital, carbamazepine and a combination of both on corazol-induced changes in the bioelectric activity of rat brains.
Topics: Animals; Brain; Carbamazepine; Electroencephalography; Epilepsy; Male; Pentylenetetrazole; Phenobarb | 1992 |
Intrinsic and drug-induced seizures of adult and developing gerbils.
Topics: Animals; Behavior, Animal; Brain; Electroencephalography; Epilepsy; Gerbillinae; Neurotransmitter Ag | 1992 |
Alterations in vasoactive intestinal polypeptide-related peptides after pentylenetetrazole-induced seizures in rat brain.
Topics: Amino Acid Sequence; Animals; Brain; Chromatography, High Pressure Liquid; Epilepsy; Injections, Int | 1992 |
Tolerance to the anticonvulsant effects of clobazam in mice.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepino | 1992 |
Age-dependent alteration in regional cerebrovascular permeability during drug-induced epilepsy.
Topics: Aging; Animals; Blood-Brain Barrier; Capillary Permeability; Cerebrovascular Circulation; Epilepsy; | 1992 |
Effects of the hypnotic drug etomidate in a model nervous system (Buccal ganglia, Helix pomatia).
Topics: Action Potentials; Animals; Cell Membrane; Cheek; Epilepsy; Etomidate; Ganglia; Helix, Snails; Membr | 1991 |
Anticonvulsant activity of di-n-propylacetate and brain monoamine metabolism in the rat.
Topics: Animals; Biogenic Monoamines; Brain; Catecholamines; Epilepsy; Female; gamma-Aminobutyric Acid; Homo | 1990 |
Epileptic manifestations and influence on sleep in the baboon Papio papio.
Topics: Animals; Cerebral Cortex; Electroencephalography; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Tonic-C | 1991 |
Effects of carbamazepine on bicuculline- and pentylenetetrazol-induced seizures in developing rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Bicuculline; Carbamazepine; Epilepsy; Female; Pentylene | 1991 |
Paroxysmal activity in the rabbit visual cortex induced by photostimulation.
Topics: Animals; Caffeine; Diazepam; Electroencephalography; Epilepsy; Pentylenetetrazole; Photic Stimulatio | 1991 |
[Anti-epileptic effect of the new calcium channel blocker IOS-1.1212].
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Dihydropyridines; Epilepsy; Male; Penicillins; P | 1991 |
Brahmighritham, an Ayurvedic herbal formula for the control of epilepsy.
Topics: Administration, Oral; Animals; Diazepam; Electroencephalography; Epilepsy; Injections, Intraperitone | 1991 |
Attenuation of epileptogenesis by nonsteroidal anti-inflammatory drugs in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Behavior, Animal; Electrodes; Ele | 1991 |
[Qualitative and quantitative changes in phospholipid spectra of the brain of rats with corazol-induced epilepsy].
Topics: Animals; Cerebellum; Cerebral Cortex; Chromatography, Thin Layer; Disease Models, Animal; Epilepsy; | 1991 |
On the relation between cerebral cysteinyl-leukotriene formation and epileptic seizures.
Topics: Animals; Bicuculline; Brain; Dinoprost; Epilepsy; Gerbillinae; Handling, Psychological; Kinetics; Pe | 1991 |
Alterations of A1 adenosine receptors in different mouse brain areas after pentylentetrazol-induced seizures, but not in the epileptic mutant mouse 'tottering'.
Topics: Adenosine; Animals; Brain; Epilepsy; Kinetics; Mice; Mice, Inbred BALB C; Mice, Neurologic Mutants; | 1990 |
Characterization of GABAergic seizure regulation in the midline thalamus.
Topics: Animals; Baclofen; Bicuculline; Electroencephalography; Epilepsy; Female; Flurazepam; gamma-Aminobut | 1990 |
Experimental epilepsy: electrically and chemically induced convulsions modulate experimental allergic encephalomyelitis and other immune inflammatory reactions in the rat.
Topics: Animals; Arthritis, Experimental; Electroshock; Encephalomyelitis, Autoimmune, Experimental; Epileps | 1990 |
[Effects of acute hypoxia on the development of corazol-induced seizures].
Topics: Acute Disease; Animals; Epilepsy; Hypoxia; Injections, Subcutaneous; Male; Pentylenetetrazole; Rats | 1990 |
Synchronization of cardiac autonomic neural discharge with epileptogenic activity: the lockstep phenomenon.
Topics: Animals; Arrhythmias, Cardiac; Cats; Dysautonomia, Familial; Electroencephalography; Epilepsy; Heart | 1987 |
Cardiazol-induced seizures and the concentration of lipid peroxides in the brain of rats under the influence of valproic acid and vitamin E.
Topics: Animals; Anticonvulsants; Antioxidants; Cerebral Cortex; Convulsants; Drug Therapy, Combination; Epi | 1989 |
[Effect of a Ca-channel blocker, ryodipine, on focal and generalized epileptic activity].
Topics: Animals; Calcium Channel Blockers; Epilepsies, Partial; Epilepsy; Male; Nifedipine; Pentylenetetrazo | 1989 |
Suppressive effects of intranigral injection of muscimol in three models of generalized non-convulsive epilepsy induced by chemical agents.
Topics: 4-Butyrolactone; Animals; Convulsants; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Is | 1989 |
High-frequency components in epileptiform EEG.
Topics: Algorithms; Animals; Brain; Data Interpretation, Statistical; Electroencephalography; Epilepsy; Four | 1989 |
Isatin and tribulin concentrations are increased in rabbit brain but not liver following pentylenetetrazole administration.
Topics: Anxiety; Brain; Epilepsy; Female; Indoles; Isatin; Liver; Male; Monoamine Oxidase Inhibitors; Pentyl | 1989 |
Pentylenetetrazol (PTZ)-kindling development in intact and subcortical structure lesioned rats.
Topics: Animals; Caudate Nucleus; Epilepsy; Hippocampus; Male; Pentylenetetrazole; Rats; Rats, Inbred Strain | 1989 |
[Effect of brain extracts from rats subjected to korazol kindling on generalized epileptic activity].
Topics: Animals; Brain; Drug Interactions; Epilepsy; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; M | 1989 |
Differences in the duration of the anticonvulsant action of clonazepam during ontogenesis in rats.
Topics: Animals; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Epilepsy; Male; Pentylenetet | 1989 |
A selective N-methyl-D-aspartate antagonist depresses epileptiform activity in rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Epilepsy; Evoked Potentials; Female; Folic Acid A | 1985 |
Concomitant increase of somatostatin, neuropeptide Y and glutamate decarboxylase in the frontal cortex of rats with decreased seizure threshold.
Topics: Animals; Cysteamine; Dose-Response Relationship, Drug; Epilepsy; Frontal Lobe; Glutamate Decarboxyla | 1988 |
Age-related changes in regional patterns of blood-brain barrier breakdown during epileptiform seizures induced by pentylenetetrazol.
Topics: Aging; Animals; Blood Pressure; Blood-Brain Barrier; Cell Membrane Permeability; Epilepsy; Evans Blu | 1989 |
Influence of propranolol on rhythmic electrocorticographic activity induced by metrazol in rats.
Topics: Animals; Arousal; Cerebral Cortex; Convulsants; Drug Synergism; Electroencephalography; Epilepsy; Ma | 1986 |
[Transport Ca-ATPase activity of brain synaptic membranes in rats with korazol-induced epileptic activity].
Topics: Animals; Brain; Ca(2+) Mg(2+)-ATPase; Calcium-Transporting ATPases; Electroencephalography; Epilepsy | 1987 |
Effect of aspartame on seizures in various models of experimental epilepsy.
Topics: Animals; Aspartame; Brain Chemistry; Dipeptides; Electroshock; Epilepsy; Male; Pentylenetetrazole; P | 1988 |
Actions of pentylenetetrazol (PTZ) on CA3 neurons in hippocampal slices of guinea pigs.
Topics: Animals; Calcium; Epilepsy; Extracellular Space; Guinea Pigs; Hippocampus; In Vitro Techniques; Memb | 1986 |
Evaluation of CPP, a selective NMDA antagonist, in various rodent models of epilepsy. Comparison with other NMDA antagonists, and with diazepam and phenobarbital.
Topics: Amygdala; Animals; Anticonvulsants; Aspartic Acid; Diazepam; Electroshock; Epilepsy; Female; Gerbill | 1988 |
[Anticonvulsive properties of enomelanin].
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroenc | 1986 |
Antiepileptic effects of globulin-N, an intact human immunoglobulin and its tissue-distribution in kindled cats.
Topics: Amygdala; Animals; Anticonvulsants; Autoradiography; Cats; Drug Combinations; Epilepsy; Half-Life; I | 1986 |
[Anticonvulsant properties of the cerebrospinal fluid during activation of the antiepileptic system of the brain].
Topics: Animals; Cats; Cerebellar Cortex; Electrodes, Implanted; Electroshock; Epilepsies, Partial; Epilepsy | 1988 |
Attenuation of pentylenetetrazol kindling of epileptogenesis in rats by dopaminergic agents.
Topics: Amantadine; Amphetamine; Animals; Epilepsy; Haloperidol; Kindling, Neurologic; Levodopa; Male; Metoc | 1988 |
Epileptic discharges induced by pentylenetetrazol: changes of shape of dendrites.
Topics: Animals; Dendrites; Epilepsy; Ganglia; Helix, Snails; In Vitro Techniques; Pentylenetetrazole; Refer | 1988 |
The effect of intracerebroventricular D-ALA2 methionine enkephalinamide and naloxone on cardiovascular parameters in the cat.
Topics: Animals; Blood Pressure; Cats; Cerebral Ventricles; Enkephalin, Methionine; Epilepsy; Heart; Heart C | 1988 |
Pentylenetetrazol seizure threshold and extracellular levels of cortical amino acids in taurine-deficient kittens.
Topics: Amino Acids; Animals; Cats; Cerebral Cortex; Epilepsy; Extracellular Space; Female; Kainic Acid; Mal | 1987 |
The role of enkephalins in the production of epileptogenic activity and autonomic dysfunction: origin of arrhythmia and sudden death in the epileptic patient?
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Blood Pressure; Death, Sudden; Enkephalins; | 1987 |
Diagnosis of primary generalized epilepsy in a cow.
Topics: Animals; Cattle; Cattle Diseases; Electroencephalography; Epilepsy; Female; Pentylenetetrazole | 1987 |
Hyperbaric oxygen induced experimental epilepsy: the age factor.
Topics: Aging; Animals; Disease Models, Animal; Epilepsy; Hyperbaric Oxygenation; Male; Mice; Mice, Inbred S | 1986 |
Pathophysiological aspects of blood-brain barrier permeability in epileptic seizures.
Topics: Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Cerebrovascular Circulation; Endothelium; | 1986 |
[Effect of exogenous DNA on convulsive activity].
Topics: Animals; DNA; Drug Evaluation, Preclinical; Electroencephalography; Epilepsy; Helix, Snails; Humans; | 1986 |
EEG effects of i.v. infusion of pentylenetetrazol in rats: a model for screening and classifying antiepileptic compounds.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Electroencephalograp | 1985 |
Effect of phenobarbital pretreatment on cardiac neural discharge and pentylenetetrazol-induced epileptogenic activity in the cat.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Cats; Dose-Response Relationship, Drug; Electrocardio | 1985 |
[Mechanisms of development and blockade of epileptic activity in the brain].
Topics: Animals; Anticonvulsants; Camphor; Cell Membrane Permeability; Cobalt; Convulsants; Electric Conduct | 1985 |
[Effect of destruction of the hippocampus and caudate nucleus on the development of epileptic activity during corazole kindling].
Topics: Animals; Caudate Nucleus; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Pentylenetetrazole; Rat | 1985 |
Pentylenetetrazol-induced seizures produce an increased release of IR-Met-enkephalin from rat striatum in vitro.
Topics: Animals; Corpus Striatum; Enkephalin, Methionine; Epilepsy; gamma-Aminobutyric Acid; In Vitro Techni | 1985 |
Patterns of cortical population discharges during metrazol-induced seizures in cats.
Topics: Animals; Cats; Cerebral Cortex; Computers; Cortical Synchronization; Disease Models, Animal; Electri | 1972 |
An electronic device for continuous counting of chemically induced epileptic discharges.
Topics: Action Potentials; Animals; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epileps | 1974 |
Intracarotid amobarbital and metrazol test for the study of epileptiform discharges in man: a note on its technique.
Topics: Amobarbital; Carotid Arteries; Cerebral Angiography; Electroencephalography; Epilepsy; Humans; Injec | 1966 |
Technique and results of micro-electrode recording in human epileptogenic foci.
Topics: Action Potentials; Cerebral Cortex; Drug Tolerance; Electroencephalography; Epilepsy; Humans; Neuron | 1967 |
Contributions of the intracarotid sodium amytal and metrazol tests to the understanding of the mechanism of "centrencephalic" epilepsy.
Topics: Amobarbital; Cerebral Cortex; Electroencephalography; Epilepsy; Humans; Injections, Intra-Arterial; | 1968 |
On the electroencephalogram of man. Fourteenth report.
Topics: Adolescent; Adult; Anesthesia; Attention; Cerebral Cortex; Electrodes; Electroencephalography; Epile | 1969 |
Central nervous system toxic manifestations of sodium cyanate.
Topics: Age Factors; Animals; Behavior, Animal; Brain; Cyanates; Epilepsy; Epilepsy, Tonic-Clonic; Pentylene | 1974 |
Isolated head of the turtle- a useful experimental model in the physiology and pathophysiology of the brain.
Topics: Animals; Brain; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Electroencephalograph | 1973 |
[Neurophysiologic models of epilepsy].
Topics: Action Potentials; Animals; Brain; Cats; Cell Membrane Permeability; Cold Temperature; Cortical Spre | 1972 |
Differential effects of pentylenetetrazol on REM sleep in naive and cobalt-epileptic rats.
Topics: Animals; Cerebral Cortex; Cobalt; Disease Models, Animal; Electroencephalography; Electromyography; | 1974 |
Metabolic effects of seizures.
Topics: Acidosis; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Bicarbonates; Blood Flow Velocity; | 1974 |
The effect of some androgenic steroids on anesthesia.
Topics: Anesthesia, Intravenous; Animals; Castration; Epilepsy; Female; Male; Methandrostenolone; Methyltest | 1968 |
EEG activation with Dimefline hydrochloride.
Topics: Adolescent; Adult; Alcoholism; Central Nervous System Stimulants; Craniocerebral Trauma; Electroence | 1969 |
Cobalt experimental epilepsy in various strains of rat.
Topics: Animals; Cerebral Cortex; Cobalt; Cricetinae; Disease Models, Animal; Epilepsy; Gerbillinae; Guinea | 1973 |
[Chemical methods of activation in diagnosis of epilepsy].
Topics: Adolescent; Adult; Barbiturates; Bemegride; Cerebral Cortex; Electroencephalography; Epilepsy; Ethan | 1972 |
Anticonvulsive action of increased calcium concentration in cerebrospinal fluid.
Topics: Acetylcholine; Animals; Anticonvulsants; Calcium; Cats; Disease Models, Animal; Dose-Response Relati | 1973 |
Brain-stem and cortical mechanisms in an animal model of generalized corticoreticular epilepsy.
Topics: Amobarbital; Animals; Arousal; Brain Stem; Cats; Cerebral Cortex; Cortical Synchronization; Disease | 1973 |
Activity of alpha and gamma extensor motor axons during metrazol-induced seizures in cat.
Topics: Action Potentials; Animals; Cats; Cerebral Decortication; Disease Models, Animal; Electroencephalogr | 1974 |
Seizure inhibition by median raphe nucleus stimulation in rat.
Topics: Amygdala; Animals; Disease Models, Animal; Electric Stimulation; Electroencephalography; Epilepsy; E | 1974 |
Extrasynaptic mechanisms of Cardiazol-induced epileptiform activity of invertebrate neurons.
Topics: Action Potentials; Animals; Calcium; Disease Models, Animal; Electric Stimulation; Epilepsy; Ganglia | 1974 |
Electrophysiologic analysis of epileptic beagles.
Topics: Acoustic Stimulation; Amygdala; Animals; Brain; Cerebral Cortex; Dogs; Electroencephalography; Epile | 1974 |
[Experimental studies of epileptic reactions. Chronic stimulations of the sensomotor cortex of the cat and the rabbit].
Topics: Adult; Aged; Aluminum; Animals; Cats; Cerebral Cortex; Child; Electrodes; Electroencephalography; Ep | 1968 |
Metrazol and the evaluation of seizures.
Topics: Epilepsy; Humans; Military Medicine; Pentylenetetrazole | 1970 |
[Experimental and clinical results of a new anti-epileptic: sodium di-n-propyl acetate (DPA) specialized under the marketed name, Depakine. Second study].
Topics: Acetates; Adolescent; Animals; Anticonvulsants; Behavior; Child; Child, Preschool; Electroencephalog | 1969 |
Serum cholesterol in monkeys with chronic epileptic foci.
Topics: Animals; Cholesterol; Epilepsies, Partial; Epilepsy; Female; Haplorhini; Male; Pentylenetetrazole; S | 1971 |
Cerebral metabolism and blood flow during induced epilepsy.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Central Venous Pressure; Cerebral Cortex; Cerebrovascu | 1967 |
Dispersion curve of responses evoked by visual stimuli. Method for analysis of stochastic mechanisms involved in information processing in the brain.
Topics: Adult; Alcohol Amnestic Disorder; Animals; Brain; Cats; Coma; Computers; Electroencephalography; Epi | 1971 |
[Significance and limitation in activation by drugs seen in the basic patterns of electroencephalography--activation by pentetrazole and bemegride].
Topics: Adolescent; Adult; Bemegride; Electroencephalography; Epilepsy; Humans; Middle Aged; Pentylenetetraz | 1971 |
[Experimental epilepsy. Study on the origin and transmission of the spike wave].
Topics: Animals; Cats; Cerebral Cortex; Electroencephalography; Epilepsy; Gyrus Cinguli; Pentylenetetrazole; | 1971 |
Generalized epileptic seizures, induced by "non-convulsant" substances. 2. Experimental study with special reference to ammonium chloride.
Topics: Adult; Ammonium Chloride; Animals; Cats; Electroencephalography; Epilepsy; Humans; Hypoxia, Brain; I | 1968 |
[Clinical, electroencephalographic and polygraphic studies of sleep in spasmophilia. Relation of spasmophilia to epilepsy, organic diseases of the nervous system, and neuroses].
Topics: Bemegride; Brain Diseases; Electroencephalography; Electromyography; Epilepsy; Humans; Neurotic Diso | 1970 |
[Contribution of daizepam (valium) to the completion of cardiazolic activation in clinical electroencephalography].
Topics: Diazepam; Drug Synergism; Electroencephalography; Epilepsy; Humans; Pentylenetetrazole | 1967 |
[Characteristics of Metrazol and Megimide for activation of seizure discharge--experimental study and their clinical uses].
Topics: Adolescent; Adult; Animals; Bemegride; Body Weight; Cats; Cerebral Cortex; Child; Electroencephalogr | 1967 |
Deep temporal stimulation in man. Long latency, long lasting psychological changes.
Topics: Action Potentials; Adult; Amygdala; Behavior; Cocaine; Electric Stimulation; Electrodes; Electroence | 1969 |
The effect of local cerebral hypothermia on the electrocorticogram and on experimental epileptic activity.
Topics: Activation Analysis; Animals; Cerebral Cortex; Dogs; Electroencephalography; Epilepsy; Hypothermia, | 1965 |
The metrazol activation of the normal brain.
Topics: Adult; Brain; Brain Diseases; Electroencephalography; Epilepsy; Humans; Male; Pentylenetetrazole; Se | 1965 |
Convulsions and sugar transport in brain.
Topics: Animals; Biological Transport; Cell Membrane Permeability; Cerebral Cortex; Child; Electric Stimulat | 1966 |
[Experimental study of post-critical electrical silence].
Topics: Animals; Cats; Electroencephalography; Epilepsy; Pentylenetetrazole; Strychnine | 1966 |
[On the pharmacological action spectrum of some new hydrazine derivatives].
Topics: Animals; Anura; Blood Pressure; Body Temperature; Cats; Drug Synergism; Electroshock; Epilepsy; Feve | 1966 |