pentylenetetrazole has been researched along with Epilepsy, Reflex in 12 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Epilepsy, Reflex: A subtype of epilepsy characterized by seizures that are consistently provoked by a certain specific stimulus. Auditory, visual, and somatosensory stimuli as well as the acts of writing, reading, eating, and decision making are examples of events or activities that may induce seizure activity in affected individuals. (From Neurol Clin 1994 Feb;12(1):57-8)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This paper comprises a series of experiments in rodent models of partial and generalized epilepsy which were designed to describe the anti-convulsant profile of the functionalized amino acid lacosamide." | 7.74 | Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy. ( Choi, D; Harris, RH; Kohn, H; Kupferberg, HJ; Stables, JP; Stöhr, T; Walton, N; White, HS, 2007) |
| "KM rats exhibited increased seizure severity relative to Wistar rats, and the death of KM rats was observed in 2." | 5.38 | [The effect of ionotropic glutamate receptor antagonist on pentylenetetrazole-indused seizures in Krushinsky-Molodkina rats]. ( Kim, KKh; Lavrent'eva, VV; Lukomskaia, NIa; Magazanik, LG; Vataev, SI; Zaĭtsev, AV; Zhabko, EP, 2012) |
| "This paper comprises a series of experiments in rodent models of partial and generalized epilepsy which were designed to describe the anti-convulsant profile of the functionalized amino acid lacosamide." | 3.74 | Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy. ( Choi, D; Harris, RH; Kohn, H; Kupferberg, HJ; Stables, JP; Stöhr, T; Walton, N; White, HS, 2007) |
| "In mice VGD afforded complete protection against maximal electroshock (MES)-, pentylenetetrazole-, picrotoxin-, and bicuculline-induced seizures and 6-Hz "psychomotor" seizures with median effective dose (ED50) values of 151, 132, 275, 248, and 237 mg/kg, respectively." | 3.71 | Anticonvulsant profile of valrocemide (TV1901): a new antiepileptic drug. ( Bialer, M; Isoherranen, N; White, HS; Woodhead, JH, 2001) |
| " No differences in convulsive thresholds to Metrazol were obtained, however, between untreated Swiss-Webster mice and mice of the same strain made audiosuseptible by rubidium chloride intake or magnesium deficiency." | 3.66 | Metrazol thresholds in inbred and non-inbred audiosensitive mice. ( Alexander, GJ; Alexander, RB; Kopeloff, LM, 1981) |
| "Treatment with finasteride increased seizure susceptibility and depression due to decreased progesterone and elevated estrogen levels coupled with decreased monoamine and elevated corticosterone levels." | 1.72 | Anticonvulsant Effect of Asparagus racemosus Willd. in a Mouse Model of Catamenial Epilepsy. ( Goel, RK; Pahwa, P; Singh, T, 2022) |
| "KM rats exhibited increased seizure severity relative to Wistar rats, and the death of KM rats was observed in 2." | 1.38 | [The effect of ionotropic glutamate receptor antagonist on pentylenetetrazole-indused seizures in Krushinsky-Molodkina rats]. ( Kim, KKh; Lavrent'eva, VV; Lukomskaia, NIa; Magazanik, LG; Vataev, SI; Zaĭtsev, AV; Zhabko, EP, 2012) |
| "Seizures are a common phenotype in all of these neurological disorders, yet the underlying molecular mechanism(s) of seizure induction and propagation remain largely unknown." | 1.36 | Alzheimer's disease and Down syndrome rodent models exhibit audiogenic seizures. ( Malter, JS; Westmark, CJ; Westmark, PR, 2010) |
| "Third, forebrain seizures were induced in genetically epilepsy-prone rats (GEPRs) by microinfusion of bicuculline into the area tempestas (AT), while brainstem seizures in GEPRs were induced by audiogenic stimulation." | 1.32 | Comparative fos immunoreactivity in the brain after forebrain, brainstem, or combined seizures induced by electroshock, pentylenetetrazol, focally induced and audiogenic seizures in rats. ( Browning, RA; Clough, RW; Eells, JB; Jobe, PC, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Pahwa, P | 1 |
| Singh, T | 1 |
| Goel, RK | 1 |
| Kim, KKh | 1 |
| Zaĭtsev, AV | 1 |
| Lavrent'eva, VV | 1 |
| Zhabko, EP | 1 |
| Vataev, SI | 1 |
| Lukomskaia, NIa | 1 |
| Magazanik, LG | 1 |
| Stafstrom, CE | 1 |
| Ockuly, JC | 1 |
| Murphree, L | 1 |
| Valley, MT | 1 |
| Roopra, A | 1 |
| Sutula, TP | 1 |
| Westmark, CJ | 1 |
| Westmark, PR | 1 |
| Malter, JS | 1 |
| Rubio, C | 1 |
| Rubio-Osornio, M | 1 |
| Retana-Márquez, S | 1 |
| Verónica Custodio, ML | 1 |
| Paz, C | 1 |
| SWINYARD, EA | 1 |
| CASTELLION, AW | 1 |
| FINK, GB | 1 |
| GOODMAN, LS | 1 |
| KESNER, RP | 1 |
| O'KELLY, LI | 1 |
| THOMAS, GJ | 1 |
| Eells, JB | 1 |
| Clough, RW | 1 |
| Browning, RA | 1 |
| Jobe, PC | 1 |
| White, HS | 3 |
| Watson, WP | 1 |
| Hansen, SL | 1 |
| Slough, S | 1 |
| Perregaard, J | 1 |
| Sarup, A | 1 |
| Bolvig, T | 1 |
| Petersen, G | 1 |
| Larsson, OM | 1 |
| Clausen, RP | 1 |
| Frølund, B | 1 |
| Falch, E | 1 |
| Krogsgaard-Larsen, P | 1 |
| Schousboe, A | 1 |
| Alexander, GJ | 1 |
| Kopeloff, LM | 1 |
| Alexander, RB | 1 |
| Stöhr, T | 1 |
| Kupferberg, HJ | 1 |
| Stables, JP | 1 |
| Choi, D | 1 |
| Harris, RH | 1 |
| Kohn, H | 1 |
| Walton, N | 1 |
| Isoherranen, N | 1 |
| Woodhead, JH | 1 |
| Bialer, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Sodium-Glucose Cotransporter-2 Inhibitors: A Potential Novel Treatment for Epilepsy[NCT05512130] | Early Phase 1 | 18 participants (Anticipated) | Interventional | 2022-08-17 | Recruiting | ||
| STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis[NCT05603702] | Phase 1 | 24 participants (Anticipated) | Interventional | 2023-03-17 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pentylenetetrazole and Epilepsy, Reflex
| Article | Year |
|---|---|
In vivo experimental models of epilepsy.
Topics: Aluminum Hydroxide; Animals; Bicuculline; Cobalt; Convulsants; Disease Models, Animal; Electroshock; | 2010 |
11 other studies available for pentylenetetrazole and Epilepsy, Reflex
| Article | Year |
|---|---|
Anticonvulsant Effect of Asparagus racemosus Willd. in a Mouse Model of Catamenial Epilepsy.
Topics: Animals; Anticonvulsants; Convulsants; Epilepsy, Reflex; Female; Horses; Mice; Pentylenetetrazole; P | 2022 |
[The effect of ionotropic glutamate receptor antagonist on pentylenetetrazole-indused seizures in Krushinsky-Molodkina rats].
Topics: Animals; Anticonvulsants; Cyclohexylamines; Epilepsy, Reflex; Excitatory Amino Acid Antagonists; Fem | 2012 |
Anticonvulsant and antiepileptic actions of 2-deoxy-D-glucose in epilepsy models.
Topics: Animals; Anticonvulsants; Deoxyglucose; Disease Models, Animal; Dose-Response Relationship, Drug; El | 2009 |
Alzheimer's disease and Down syndrome rodent models exhibit audiogenic seizures.
Topics: Acoustic Stimulation; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Convulsants; Down | 2010 |
Some neurophysiological and neuropharmacological characteristics of audiogenic-seizure-susceptible mice.
Topics: Animals; Epilepsy, Reflex; Mice; Pentylenetetrazole; Seizures | 1963 |
EFFECTS OF CORTICAL SPREADING DEPRESSION AND DRUGS UPON AUDIOGENIC SEIZURES IN RATS.
Topics: Brain; Cerebral Cortex; Cortical Spreading Depression; Electrophysiology; Epilepsy; Epilepsy, Reflex | 1965 |
Comparative fos immunoreactivity in the brain after forebrain, brainstem, or combined seizures induced by electroshock, pentylenetetrazol, focally induced and audiogenic seizures in rats.
Topics: Animals; Brain Stem; Electroshock; Epilepsy, Reflex; Immunohistochemistry; Pentylenetetrazole; Prose | 2004 |
First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2.
Topics: Acoustic Stimulation; Acyltransferases; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Cells, | 2005 |
Metrazol thresholds in inbred and non-inbred audiosensitive mice.
Topics: Acoustic Stimulation; Animals; Convulsants; Epilepsy, Reflex; Magnesium Deficiency; Male; Mice; Pent | 1981 |
Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy.
Topics: Acetamides; Animals; Anticonvulsants; Bicuculline; Cobalt; Convulsants; Electroshock; Epilepsies, Pa | 2007 |
Anticonvulsant profile of valrocemide (TV1901): a new antiepileptic drug.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Respo | 2001 |