pentylenetetrazole has been researched along with Epilepsy, Absence in 60 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Epilepsy, Absence: A seizure disorder usually occurring in childhood characterized by rhythmic electrical brain discharges of generalized onset. Clinical features include a sudden cessation of ongoing activity usually without loss of postural tone. Rhythmic blinking of the eyelids or lip smacking frequently accompanies the SEIZURES. The usual duration is 5-10 seconds, and multiple episodes may occur daily. Juvenile absence epilepsy is characterized by the juvenile onset of absence seizures and an increased incidence of myoclonus and tonic-clonic seizures. (Menkes, Textbook of Child Neurology, 5th ed, p736)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the pentylenetetrazole-induced seizure model, 1, 5, or 10 mg/kg vortioxetine demonstrated a significant dose-dependent decrease in mean spike frequency, an increase in the latency to minor and major seizures, and a decrease in total duration of major seizure and convulsion stage." | 8.02 | Vortioxetine increases absence-like seizures in WAG/Rij rats but decreases penicillin- and pentylenetetrazole-induced seizures in Wistar rats. ( Aygun, H; Ayyildiz, M, 2021) |
| "Dravet syndrome is characterized by multiple seizure types: generalized tonic-clonic, focal, myoclonic, and absence seizures." | 5.72 | Stiripentol inhibits spike-and-wave discharges in animal models of absence seizures: A new mechanism of action involving T-type calcium channels. ( Heulard, I; Reversat, L; Riban, V; Si Hocine, H; Verleye, M, 2022) |
| "Using chemogenetics, we evaluated the effect of ANT parvalbumin (PV) neurons on pentylenetetrazole (PTZ)-induced absence seizures in mice." | 4.31 | Parvalbumin neurons in the anterior nucleus of thalamus control absence seizures. ( Jiang, T; Sun, Y; Tuo, M; Wang, J; Wang, Y; Yu, X; Zhang, M; Zhang, X; Zhao, Z, 2023) |
| " In the pentylenetetrazole-induced seizure model, 1, 5, or 10 mg/kg vortioxetine demonstrated a significant dose-dependent decrease in mean spike frequency, an increase in the latency to minor and major seizures, and a decrease in total duration of major seizure and convulsion stage." | 4.02 | Vortioxetine increases absence-like seizures in WAG/Rij rats but decreases penicillin- and pentylenetetrazole-induced seizures in Wistar rats. ( Aygun, H; Ayyildiz, M, 2021) |
| "In the current study the link among the γ-hydroxybutyrate (GHB)/pentylenetetrazole (PTZ)-induced absence-like seizures and concomitant decreases in the core temperature, as well as electroencephalographic (EEG) activity during rewarming from deep hypothermia produced by a drug-free protocol were investigated." | 3.79 | GABAB receptors as a common target for hypothermia and spike and wave seizures: intersecting mechanisms of thermoregulation and absence epilepsy. ( Andjus, PR; Ilić, TV; Ostojić, ZS; Vesković, SM, 2013) |
| "This study was designed to evaluate the blood-brain barrier permeability characteristics of the WAG/Rij strain of rats that are an ideal model for human absence epilepsy, in controls and pentylenetetrazole-induced seizures conditioned to Evans blue-albumin." | 3.70 | Absence epilepsy and regional blood-brain barrier permeability: the effects of pentylenetetrazole-induced convulsions. ( Ates, N; Esen, N; Ilbay, G, 1999) |
| "The results of surgical treatment of intractable epilepsy seizures in a group of patients investigated with the intracarotid amobarbital-pentylenetetrazol EEG test were analyzed." | 3.65 | Role of the intracarotid amobarbital-pentylenetetrazol EEG test in the diagnosis and surgical treatment of patients with complex seizure problems. ( Altuzarra, A; Garretson, H; Gloor, P; Rasmussen, T, 1976) |
| "Dravet syndrome is characterized by multiple seizure types: generalized tonic-clonic, focal, myoclonic, and absence seizures." | 1.72 | Stiripentol inhibits spike-and-wave discharges in animal models of absence seizures: A new mechanism of action involving T-type calcium channels. ( Heulard, I; Reversat, L; Riban, V; Si Hocine, H; Verleye, M, 2022) |
| "Caffeine treatment at a daily dose of 10 and/or 20 mg/kg, sc was executed during postnatal days 7-11." | 1.39 | Different effects of postnatal caffeine treatment on two pentylenetetrazole-induced seizure models persist into adulthood. ( Kubová, H; Mareš, P; Tchekalarova, JD, 2013) |
| " No tolerance was evident in the intravenous pentylenetetrazol test after twice-daily dosing of ABT-769 (0." | 1.33 | Preclinical profiling and safety studies of ABT-769: a compound with potential for broad-spectrum antiepileptic activity. ( Bennani, Y; Bitner, RS; Chemburkar, SR; Chen, J; Curzon, P; Dart, MJ; Decker, MW; Durmuller, N; Fox, GB; Giardina, WJ; Grayson, GK; Harris, RR; Hui, JY; Jolly, R; Komater, VA; Ku, Y; Lockwood, M; Marsh, KC; Miner, HM; Nikkel, AL; Pan, JB; Pu, YM; Radek, RJ; Roux, S; Sullivan, JP; Wang, L; Waring, JF, 2005) |
| "Ethosuximide (ESM) also was used to block seizure activity." | 1.33 | Imaging the neural substrates involved in the genesis of pentylenetetrazol-induced seizures. ( Brevard, ME; Ferris, CF; King, JA; Kulkarni, P, 2006) |
| "Acetone has been shown to suppress experimental seizures." | 1.32 | Anticonvulsant properties of acetone, a brain ketone elevated by the ketogenic diet. ( Burnham, WM; Cortez, MA; Likhodii, SS; Murphy, P; Serbanescu, I; Snead, OC, 2003) |
| "Seizures were induced by repetitive injections of subconvulsive doses of PTZ." | 1.30 | Mapping of neuronal networks underlying generalized seizures induced by increasing doses of pentylenetetrazol in the immature and adult rat: a c-Fos immunohistochemical study. ( André, V; Marescaux, C; Motte, JE; Nehlig, A; Pineau, N, 1998) |
| "Ganaxolone pretreatment resulted in a significant prolongation of absence seizure in both the PTZ and GHB models." | 1.30 | Ganaxolone, a selective, high-affinity steroid modulator of the gamma-aminobutyric acid-A receptor, exacerbates seizures in animal models of absence. ( Snead, OC, 1998) |
| "In conclusion, the results confirm a genetic susceptibility in GAERS and/or resistance in inbred non-epileptic rats to focal and generalized seizures involving the cortex." | 1.30 | Susceptibility to focal and generalized seizures in Wistar rats with genetic absence-like epilepsy. ( Boehrer, A; Brailowsky, S; Marescaux, C; Montiel, T; Vergnes, M, 1999) |
| "Although calcium antagonists possess antiepileptic properties in various models of epilepsy, their role after chronic administration and in models for generalized absence epilepsy has not been studied." | 1.29 | The effects of chronic treatment with a calcium channel antagonist on two types of generalized epilepsies in rats. ( Ates, N; van der Staay, FJ; van Luijtelaar, EL, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (36.67) | 18.7374 |
| 1990's | 17 (28.33) | 18.2507 |
| 2000's | 10 (16.67) | 29.6817 |
| 2010's | 8 (13.33) | 24.3611 |
| 2020's | 3 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Riban, V | 1 |
| Heulard, I | 1 |
| Reversat, L | 1 |
| Si Hocine, H | 1 |
| Verleye, M | 1 |
| Zhang, X | 1 |
| Yu, X | 1 |
| Tuo, M | 1 |
| Zhao, Z | 1 |
| Wang, J | 1 |
| Jiang, T | 1 |
| Zhang, M | 1 |
| Wang, Y | 2 |
| Sun, Y | 1 |
| Yavuz, M | 1 |
| Albayrak, N | 1 |
| Özgür, M | 1 |
| Gülçebi İdriz Oğlu, M | 1 |
| Çavdar, S | 1 |
| Onat, F | 1 |
| Aygun, H | 1 |
| Ayyildiz, M | 1 |
| Peng, YC | 1 |
| Wang, S | 1 |
| Zhang, Y | 1 |
| Huang, LJ | 1 |
| Wang, XL | 1 |
| Peng, Y | 1 |
| Ostojić, ZS | 1 |
| Ilić, TV | 1 |
| Vesković, SM | 1 |
| Andjus, PR | 1 |
| Tchekalarova, JD | 1 |
| Kubová, H | 3 |
| Mareš, P | 5 |
| Ekici, F | 1 |
| Gürol, G | 1 |
| Ateş, N | 4 |
| Witsch, J | 1 |
| Golkowski, D | 1 |
| Hahn, TT | 1 |
| Petrou, S | 1 |
| Spors, H | 1 |
| Chen, SD | 1 |
| Yeh, KH | 1 |
| Huang, YH | 1 |
| Shaw, FZ | 2 |
| Russo, E | 1 |
| Scicchitano, F | 1 |
| Citraro, R | 2 |
| Aiello, R | 1 |
| Camastra, C | 1 |
| Mainardi, P | 1 |
| Chimirri, S | 1 |
| Perucca, E | 1 |
| Donato, G | 1 |
| De Sarro, G | 2 |
| Likhodii, SS | 1 |
| Serbanescu, I | 1 |
| Cortez, MA | 1 |
| Murphy, P | 1 |
| Snead, OC | 7 |
| Burnham, WM | 1 |
| BENNETT, FE | 1 |
| VETTER, K | 1 |
| GAENSHIRT, H | 1 |
| FREY, HH | 1 |
| McLean, KJ | 1 |
| O'Brien, TJ | 1 |
| Cook, MJ | 1 |
| Vajda, FJ | 1 |
| Akman, O | 1 |
| Karson, A | 1 |
| Giardina, WJ | 1 |
| Dart, MJ | 1 |
| Harris, RR | 1 |
| Bitner, RS | 1 |
| Radek, RJ | 1 |
| Fox, GB | 1 |
| Chemburkar, SR | 1 |
| Marsh, KC | 1 |
| Waring, JF | 1 |
| Hui, JY | 1 |
| Chen, J | 1 |
| Curzon, P | 1 |
| Grayson, GK | 1 |
| Komater, VA | 1 |
| Ku, Y | 1 |
| Lockwood, M | 1 |
| Miner, HM | 1 |
| Nikkel, AL | 1 |
| Pan, JB | 1 |
| Pu, YM | 1 |
| Wang, L | 1 |
| Bennani, Y | 1 |
| Durmuller, N | 1 |
| Jolly, R | 1 |
| Roux, S | 1 |
| Sullivan, JP | 1 |
| Decker, MW | 1 |
| Brevard, ME | 1 |
| Kulkarni, P | 1 |
| King, JA | 1 |
| Ferris, CF | 1 |
| Nassiri-Asl, M | 1 |
| Shariati-Rad, S | 1 |
| Zamansoltani, F | 1 |
| Ngomba, RT | 1 |
| Ferraguti, F | 1 |
| Badura, A | 1 |
| Santolini, I | 1 |
| Battaglia, G | 1 |
| Bruno, V | 1 |
| Simonyi, A | 1 |
| van Luijtelaar, G | 1 |
| Nicoletti, F | 1 |
| Marescaux, C | 3 |
| Micheletti, G | 1 |
| Vergnes, M | 2 |
| Depaulis, A | 1 |
| Rumbach, L | 1 |
| Warter, JM | 1 |
| Hosford, DA | 1 |
| Liu, CC | 1 |
| van Luijtelaar, EL | 1 |
| van der Staay, FJ | 1 |
| Banerjee, PK | 1 |
| Velísek, L | 2 |
| Vondricková, R | 2 |
| André, V | 1 |
| Pineau, N | 1 |
| Motte, JE | 1 |
| Nehlig, A | 1 |
| Esen, N | 1 |
| Ilbay, G | 1 |
| Brailowsky, S | 1 |
| Montiel, T | 1 |
| Boehrer, A | 1 |
| Shantilal, P | 1 |
| David, J | 2 |
| Joseph, T | 2 |
| Morgant, G | 1 |
| Dung, NH | 1 |
| Daran, JC | 1 |
| Viossat, B | 1 |
| Labouze, X | 1 |
| Roch-Arveiller, M | 1 |
| Greenaway, FT | 1 |
| Cordes, W | 1 |
| Sorenson, JR | 1 |
| Kumaresan, S | 1 |
| Arushanian, EB | 3 |
| Avakian, RM | 2 |
| Vol'f, MSh | 1 |
| Gloor, P | 3 |
| Rasmussen, T | 1 |
| Altuzarra, A | 1 |
| Garretson, H | 1 |
| Shearer, DE | 1 |
| Fleming, DE | 1 |
| Bigler, ED | 1 |
| Woodbury, JW | 1 |
| Woodbury, DM | 1 |
| Coulter, DA | 2 |
| Huguenard, JR | 2 |
| Prince, DA | 2 |
| Schickerová, R | 1 |
| Trojan, S | 1 |
| Gallitto, G | 1 |
| Musolino, R | 1 |
| Aliquò, G | 1 |
| Bruno, A | 1 |
| De Domenico, P | 1 |
| Marlara, CE | 1 |
| Marabello, L | 1 |
| Puglisi, RM | 1 |
| Sturniolo, R | 1 |
| Di Perri, R | 1 |
| Santucci, V | 1 |
| Fournier, M | 1 |
| Keane, P | 1 |
| Simiand, J | 1 |
| Michaud, JC | 1 |
| Morre, M | 1 |
| Biziere, K | 1 |
| Testa, G | 1 |
| Browne, TR | 1 |
| Penry, JK | 1 |
| Marcus, EM | 1 |
| Watson, CW | 1 |
| Müller, D | 1 |
| Schulz, H | 1 |
| Roberge, A | 1 |
| Charbonneau, R | 1 |
| de Biolley, D | 1 |
| Sorel, L | 1 |
| Fromm, GH | 1 |
| Killian, JM | 1 |
| Sanchez, F | 1 |
| Walker, AE | 1 |
| Morello, G | 1 |
2 reviews available for pentylenetetrazole and Epilepsy, Absence
| Article | Year |
|---|---|
Pharmacological models of generalized absence seizures in rodents.
Topics: Animals; Disease Models, Animal; Epilepsy, Absence; Isoxazoles; Penicillins; Pentylenetetrazole; Rod | 1992 |
Benzodiazepines in the treatment of epilepsy. A review.
Topics: Adult; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Disease Models, Animal; Eclampsia; Elec | 1973 |
1 trial available for pentylenetetrazole and Epilepsy, Absence
| Article | Year |
|---|---|
Observations on the discrepancy between the clinical and the laboratory effects of anti-petit mal drugs.
Topics: Action Potentials; Anticonvulsants; Chloralose; Clinical Trials as Topic; Diazepam; Epilepsy, Absenc | 1967 |
57 other studies available for pentylenetetrazole and Epilepsy, Absence
| Article | Year |
|---|---|
Stiripentol inhibits spike-and-wave discharges in animal models of absence seizures: A new mechanism of action involving T-type calcium channels.
Topics: Animals; Anticonvulsants; Calcium Channels, T-Type; Dioxolanes; Disease Models, Animal; Electroencep | 2022 |
Parvalbumin neurons in the anterior nucleus of thalamus control absence seizures.
Topics: Animals; Anterior Thalamic Nuclei; Epilepsy, Absence; Mice; Neurons; Parvalbumins; Pentylenetetrazol | 2023 |
The effect of prenatal and postnatal caffeine exposure on pentylentetrazole induced seizures in the non-epileptic and epileptic offsprings.
Topics: Animals; Brain; Caffeine; Calcium Channels, T-Type; Epilepsy, Absence; Female; Male; Pentylenetetraz | 2019 |
Vortioxetine increases absence-like seizures in WAG/Rij rats but decreases penicillin- and pentylenetetrazole-induced seizures in Wistar rats.
Topics: Animals; Depressive Disorder, Major; Disease Models, Animal; Electroencephalography; Epilepsy, Absen | 2021 |
Hsp90β inhibitors prevent GLT-1 degradation but have no beneficial efficacy on absence epilepsy.
Topics: Animals; Anticonvulsants; Benzoquinones; Epilepsy, Absence; Excitatory Amino Acid Transporter 2; Gen | 2019 |
GABAB receptors as a common target for hypothermia and spike and wave seizures: intersecting mechanisms of thermoregulation and absence epilepsy.
Topics: Animals; Anticonvulsants; Benzoates; Body Temperature Regulation; Cerebral Cortex; Diazepam; Epileps | 2013 |
Different effects of postnatal caffeine treatment on two pentylenetetrazole-induced seizure models persist into adulthood.
Topics: Aging; Animals; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsies, Myoc | 2013 |
Effects of linoleic acid on generalized convulsive and nonconvulsive epileptic seizures.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Epilepsy, Tonic-Clonic; | 2014 |
Cortical alterations in a model for absence epilepsy and febrile seizures: in vivo findings in mice carrying a human GABA(A)R gamma2 subunit mutation.
Topics: Action Potentials; Animals; Cerebral Cortex; Convulsants; Disease Models, Animal; Epilepsy, Absence; | 2015 |
Effect of intracranial administration of ethosuximide in rats with spontaneous or pentylenetetrazol-induced spike-wave discharges.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy, Absence; Ethosuximide; Infusions, | 2011 |
Protective activity of α-lactoalbumin (ALAC), a whey protein rich in tryptophan, in rodent models of epileptogenesis.
Topics: Animals; Convulsants; Epilepsy; Epilepsy, Absence; Excitatory Amino Acid Agonists; Excitatory Amino | 2012 |
Is spontaneous high-voltage rhythmic spike discharge in Long Evans rats an absence-like seizure activity?
Topics: Animals; Anticonvulsants; Arousal; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Electr | 2004 |
Anticonvulsant properties of acetone, a brain ketone elevated by the ketogenic diet.
Topics: Acetone; Amygdala; Animals; Anticonvulsants; Ataxia; Brain Chemistry; Convulsants; Diabetes Mellitus | 2003 |
Intracarotid and intravertebral metrazol in petit mal epilepsy.
Topics: Epilepsy; Epilepsy, Absence; Pentylenetetrazole | 1953 |
[A contribution to the blood supply and oxygen uptake of the brain in minor epileptic attacks. Cerebral blood supply and 02 uptake in petit mal].
Topics: Blood Pressure; Brain; Electroencephalography; Energy Metabolism; Epilepsy; Epilepsy, Absence; Human | 1962 |
NOTE ON THE INTERACTIONS OF AMPHETAMINE WITH ANTICONVULSANT DRUGS.
Topics: Amphetamine; Amphetamines; Animals; Anticonvulsants; Electricity; Electroshock; Epilepsy; Epilepsy, | 1964 |
The influence of gender on the aggravation of absence seizures by carbamazepine in the low-dose pentylenetetrazol rat model.
Topics: Animals; Anticonvulsants; Carbamazepine; Convulsants; Disease Models, Animal; Dose-Response Relation | 2004 |
The effects of the immature rat model of febrile seizures on the occurrence of later generalized tonic-clonic and absence epilepsy.
Topics: Action Potentials; Animals; Animals, Newborn; Brain; Causality; Convulsants; Disease Models, Animal; | 2005 |
Preclinical profiling and safety studies of ABT-769: a compound with potential for broad-spectrum antiepileptic activity.
Topics: Abnormalities, Drug-Induced; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Disease Models, A | 2005 |
Imaging the neural substrates involved in the genesis of pentylenetetrazol-induced seizures.
Topics: Animals; Brain Mapping; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy, Abs | 2006 |
Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors.
Topics: Animals; Anticonvulsants; Antidotes; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Re | 2007 |
Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures.
Topics: Animals; Benzopyrans; Blotting, Western; Convulsants; Densitometry; Electroencephalography; Epilepsy | 2008 |
A model of chronic spontaneous petit mal-like seizures in the rat: comparison with pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalo | 1984 |
Characterization of the antiabsence effects of SCH 50911, a GABA-B receptor antagonist, in the lethargic mouse, gamma-hydroxybutyrate, and pentylenetetrazole models.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Electroencephalography; Epilepsy | 1995 |
The effects of chronic treatment with a calcium channel antagonist on two types of generalized epilepsies in rats.
Topics: Animals; Calcium Channel Blockers; Diet; Electroencephalography; Epilepsy, Absence; Epilepsy, Genera | 1994 |
Thalamic mediodorsal and intralaminar nuclear lesions disrupt the generation of experimentally induced generalized absence-like seizures in rats.
Topics: Animals; Electric Stimulation; Electroencephalography; Epilepsy, Absence; Male; Pentylenetetrazole; | 1994 |
Effects of alprazolam on a model of human absences--rhythmic metrazol activity in rats.
Topics: Alprazolam; Animals; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Absence; Ma | 1993 |
Models of simple partial and absence seizures in freely moving rats: action of ketamine.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalo | 1993 |
Antiabsence seizure activity of specific GABAB and gamma-Hydroxybutyric acid receptor antagonists.
Topics: Animals; Anticonvulsants; Baclofen; Benzocycloheptenes; Electroencephalography; Epilepsy, Absence; G | 1996 |
Mapping of neuronal networks underlying generalized seizures induced by increasing doses of pentylenetetrazol in the immature and adult rat: a c-Fos immunohistochemical study.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Dose-Response Relationship, Drug; Electroencepha | 1998 |
Ganaxolone, a selective, high-affinity steroid modulator of the gamma-aminobutyric acid-A receptor, exacerbates seizures in animal models of absence.
Topics: Animals; Anticonvulsants; Convulsants; Epilepsy, Absence; GABA Antagonists; Hydroxybutyrates; Male; | 1998 |
Absence epilepsy and regional blood-brain barrier permeability: the effects of pentylenetetrazole-induced convulsions.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Epilepsy, Absence; Male; Pentylenetetrazole; P | 1999 |
Susceptibility to focal and generalized seizures in Wistar rats with genetic absence-like epilepsy.
Topics: Animals; Convulsants; Electroencephalography; Epilepsies, Partial; Epilepsy, Absence; Epilepsy, Gene | 1999 |
Effect of sodium valproate and flunarizine administered alone and in combination on pentylenetetrazole model of absence seizures in rat.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Synergism; Electroencephalography; Epilepsy, | 1999 |
Low-temperature crystal structures of tetrakis-mu-3,5-diisopropylsalicylatobis-dimethylformamidodico pper(II) and tetrakis-mu-3,5-diisopropylsalicylatobis-diethyletheratodicopp er(II) and their role in modulating polymorphonuclear leukocyte activity in ov
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Crystallization; Crystallography, | 2000 |
Comparative profiles of sodium valproate and ethosuximide on electro-behavioural correlates in gamma-hydroxybutyrate and pentylenetetrazol induced absence seizures in rats.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Abs | 2000 |
[Participation of monoaminergic mechanisms and the striatum in the development of "petit mal" induced by corazole].
Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Biogenic Amines; Chlorpromazine; Corpus Striatum; Drug In | 1978 |
[The dual role of the caudate nucleus in regulating seizures].
Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Brain Mapping; Cats; Caudate Nucleus; Cerebral | 1975 |
[Psychotropic drugs in the clinical picture of epilepsy (review of the literature)].
Topics: Amitriptyline; Animals; Anti-Anxiety Agents; Anticonvulsants; Antipsychotic Agents; Carbamazepine; C | 1975 |
Metrazol-induced petit mal: the role played by monoaminergic mechanisms and striatum.
Topics: Animals; Biogenic Amines; Corpus Striatum; Drug Interactions; Electric Stimulation; Electroencephalo | 1978 |
Role of the intracarotid amobarbital-pentylenetetrazol EEG test in the diagnosis and surgical treatment of patients with complex seizure problems.
Topics: Adolescent; Amobarbital; Brain; Carotid Arteries; Cerebrovascular Circulation; Depression, Chemical; | 1976 |
The photically evoked afterdischarge: a model for the study of drugs useful in the treatment of petit mal epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Absence; Evoked Potentials; Female; Pent | 1976 |
Evidence for G protein modulation of experimental-generalized absence seizures in rat.
Topics: 4-Butyrolactone; Animals; Cerebral Ventricles; Electroencephalography; Epilepsy, Absence; GTP-Bindin | 1992 |
Vagal stimulation reduces the severity of maximal electroshock seizures in intact rats: use of a cuff electrode for stimulating and recording.
Topics: Action Potentials; Animals; Autonomic Fibers, Preganglionic; Electric Stimulation Therapy; Electroca | 1991 |
Clonazepam effect on rhythmic EEG activity elicited by metrazol.
Topics: Animals; Clonazepam; Electroencephalography; Epilepsy, Absence; Male; Pentylenetetrazole; Periodicit | 1991 |
Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: GABA current blockade.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Epilepsy, Absence; Ethosuximide; gamma-Aminobuty | 1990 |
Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction.
Topics: Animals; Anticonvulsants; Calcium Channels; Convulsants; Epilepsy, Absence; Ethosuximide; gamma-Amin | 1990 |
Rhythmic metrazol activity in rats as a model of human absences.
Topics: Animals; Behavior, Animal; Convulsants; Electroencephalography; Epilepsy, Absence; Male; Pentylenete | 1989 |
Pentylenetetrazol-induced spike wave discharges in rats: a polygraphic study.
Topics: Animals; Arousal; Cerebral Cortex; Electroencephalography; Electromyography; Epilepsies, Partial; Ep | 1987 |
EEG effects of i.v. infusion of pentylenetetrazol in rats: a model for screening and classifying antiepileptic compounds.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Electroencephalograp | 1985 |
Generalized penicillin epilepsy in the cat: effects of intracarotid and intravertebral pentylenetetrazol and amobarbital injections.
Topics: Amobarbital; Animals; Brain Stem; Carotid Arteries; Cats; Cerebral Cortex; Disease Models, Animal; E | 1974 |
Bilateral synchronous spike wave electrographic patterns in the cat. Interaction of bilateral cortical foci in the intact, the bilateral cortical-callosal, and adiencephalic preparation.
Topics: Animals; Cats; Cerebral Cortex; Corpus Callosum; Electroencephalography; Epilepsy, Absence; Estrogen | 1966 |
[On the raised convulsion threshold through diazepam in therapeutic pentamethylentetrazol induced convulsion].
Topics: Adult; Cerebral Cortex; Child; Convulsive Therapy; Diazepam; Electroencephalography; Epilepsy, Absen | 1967 |
Generalized cortico-reticular epilepsies. Some considerations on the pathophysiology of generalized bilaterally synchronous spike and wave discharge.
Topics: Adult; Amobarbital; Brain Stem; Carotid Arteries; Cerebral Cortex; Electroencephalography; Epilepsy, | 1968 |
Protective effects of arginine against hepatic coma, insulin shock and epilepsy.
Topics: Ammonia; Animals; Arginine; Brain Chemistry; Epilepsy, Absence; Hepatic Encephalopathy; Hypoglycemia | 1969 |
[Experimental and clinical results of a new anti-epileptic: sodium di-n-propyl acetate (DPA) specialized under the marketed name, Depakine. Second study].
Topics: Acetates; Adolescent; Animals; Anticonvulsants; Behavior; Child; Child, Preschool; Electroencephalog | 1969 |
Experimental petit mal.
Topics: Aluminum; Amygdala; Animals; Brain; Caudate Nucleus; Disease Models, Animal; Electroencephalography; | 1967 |