pentylenetetrazole has been researched along with Encephalopathy, Toxic in 24 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This paper comprises a series of experiments in rodent models of partial and generalized epilepsy which were designed to describe the anti-convulsant profile of the functionalized amino acid lacosamide." | 7.74 | Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy. ( Choi, D; Harris, RH; Kohn, H; Kupferberg, HJ; Stables, JP; Stöhr, T; Walton, N; White, HS, 2007) |
| " Anticonvulsant effects were evaluated against seizures induced by 14 mg kg(-1) of 4-aminopyridine (4-AP) and by 110 mg kg(-1) of pentylenetetrazole (PTZ), and neurotoxicity by the rotarod test." | 7.72 | Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial? ( Amat, G; Armijo, JA; Cuadrado, A, 2003) |
| " The aim of this study was to evaluate the profile of interactions between FBM and four conventional antiepileptic drugs (AEDs): clonazepam (CZP), ethosuximide (ESM), phenobarbital (PB), and valproate (VPA), in pentylenetetrazole (PTZ)-induced convulsions in mice, a model of myoclonic seizures in humans." | 7.72 | Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ, 2004) |
| "The new N-Mannich bases were effective in maximal electroshock or pentylenetetrazole seizures screens; and the most interesting compound 4 (1-{[4-(1-phenyethyl)-piperazin-1-yl]methyl}-3',4'-dihydro-1'H,2H,5H-spiro[imidazolidine-4,2'-naphthalene]-2,5-dione) displayed anticonvulsant activity in both the aforementioned tests." | 3.83 | Design, synthesis, anticonvulsant, and antiarrhythmic properties of novel N-Mannich base and amide derivatives of β-tetralinohydantoin. ( Bednarski, M; Byrtus, H; Czopek, A; Kazek, G; Pawłowski, M; Sapa, J; Siwek, A; Zagórska, A, 2016) |
| " All the newly synthesized compounds were investigated for the anticonvulsant activity against maximal electroshock induced seizures (MES) and subcutaneous pentylenetetrazole (scPTZ) models and their neurotoxicity were also evaluated by rotarod test." | 3.81 | Anticonvulsant and Neurotoxicity of Some Novel 1-([1,3,4]thiadiazino[6,5- b]indol-3-yl Semicarbazides. ( Deshmukh, R; Jha, AK; Kumar, SP; Thakur, AS, 2015) |
| "This paper comprises a series of experiments in rodent models of partial and generalized epilepsy which were designed to describe the anti-convulsant profile of the functionalized amino acid lacosamide." | 3.74 | Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy. ( Choi, D; Harris, RH; Kohn, H; Kupferberg, HJ; Stables, JP; Stöhr, T; Walton, N; White, HS, 2007) |
| "Isobolographic analysis was used to characterize the interactions between stiripentol (STP) and clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced clonic seizures in mice." | 3.73 | Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2006) |
| " Anticonvulsant effects were evaluated against seizures induced by 14 mg kg(-1) of 4-aminopyridine (4-AP) and by 110 mg kg(-1) of pentylenetetrazole (PTZ), and neurotoxicity by the rotarod test." | 3.72 | Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial? ( Amat, G; Armijo, JA; Cuadrado, A, 2003) |
| " The aim of this study was to evaluate the profile of interactions between FBM and four conventional antiepileptic drugs (AEDs): clonazepam (CZP), ethosuximide (ESM), phenobarbital (PB), and valproate (VPA), in pentylenetetrazole (PTZ)-induced convulsions in mice, a model of myoclonic seizures in humans." | 3.72 | Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ, 2004) |
| " Results also showed that the animals fed calorie-restricted high-fat diets exhibited significant ketonemia and protection from pentylenetetrazole (PTZ)-induced seizures." | 3.70 | Higher ketogenic diet ratios confer protection from seizures without neurotoxicity. ( Bough, KJ; Eagles, DA; Yao, SG, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.17) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 14 (58.33) | 29.6817 |
| 2010's | 9 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Santos, AC | 1 |
| Temp, FR | 1 |
| Marafiga, JR | 1 |
| Pillat, MM | 1 |
| Hessel, AT | 1 |
| Ribeiro, LR | 1 |
| Miyazato, LG | 1 |
| Oliveira, MS | 1 |
| Mello, CF | 1 |
| Aboul-Enein, MN | 1 |
| El-Azzouny, AA | 1 |
| Amin, KM | 1 |
| Aboutabl, ME | 1 |
| Abo-Elmagd, MI | 1 |
| Nikalje, AP | 1 |
| Shaikh, SI | 1 |
| Mulay, A | 1 |
| Khan, FA | 1 |
| Sangshetti, JN | 1 |
| Shaikh, S | 1 |
| Rybka, S | 1 |
| Obniska, J | 1 |
| Rapacz, A | 1 |
| Filipek, B | 1 |
| Kamiński, K | 1 |
| Deshmukh, R | 1 |
| Thakur, AS | 1 |
| Jha, AK | 1 |
| Kumar, SP | 1 |
| Waszkielewicz, AM | 1 |
| Cegła, M | 1 |
| Żesławska, E | 1 |
| Nitek, W | 1 |
| Słoczyńska, K | 1 |
| Marona, H | 1 |
| Czopek, A | 1 |
| Byrtus, H | 1 |
| Zagórska, A | 1 |
| Siwek, A | 1 |
| Kazek, G | 1 |
| Bednarski, M | 1 |
| Sapa, J | 1 |
| Pawłowski, M | 1 |
| Aggarwal, N | 1 |
| Mishra, P | 1 |
| Nagori, BP | 1 |
| Aggarwal, R | 1 |
| Jain, J | 1 |
| Aytemir, MD | 2 |
| Septioğlu, E | 2 |
| Caliş, U | 6 |
| Uysal, S | 1 |
| Soyer, Z | 1 |
| Gul, HI | 2 |
| Vepsalainen, J | 1 |
| Cuadrado, A | 1 |
| Amat, G | 1 |
| Armijo, JA | 1 |
| Verma, M | 1 |
| Pandeya, SN | 1 |
| Singh, KN | 1 |
| Stables, JP | 2 |
| Borowicz, KK | 1 |
| Luszczki, JJ | 2 |
| Czuczwar, SJ | 2 |
| Huang, TP | 1 |
| Ho, IK | 1 |
| Mehendale, HM | 1 |
| Ruhoğlu, O | 1 |
| Ozdemir, Z | 2 |
| Gümüşel, B | 2 |
| Bilgin, AA | 2 |
| Kandilci, HB | 1 |
| Ratnaraj, N | 1 |
| Patsalos, PN | 1 |
| Stöhr, T | 1 |
| Kupferberg, HJ | 1 |
| Choi, D | 1 |
| Harris, RH | 1 |
| Kohn, H | 1 |
| Walton, N | 1 |
| White, HS | 1 |
| Calls, U | 1 |
| Ozturk, Z | 1 |
| Tutar, E | 1 |
| Calikiran, L | 1 |
| Kang, TC | 1 |
| Kang, JH | 1 |
| Kim, HT | 1 |
| Lee, SJ | 1 |
| Choi, UK | 1 |
| Kim, JE | 1 |
| Kwak, SE | 1 |
| Kim, DW | 1 |
| Choi, SY | 1 |
| Kwon, OS | 1 |
| Bough, KJ | 1 |
| Yao, SG | 1 |
| Eagles, DA | 1 |
| Kansal, DK | 1 |
| Chakrabarti, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis[NCT05603702] | Phase 1 | 24 participants (Anticipated) | Interventional | 2023-03-17 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
24 other studies available for pentylenetetrazole and Encephalopathy, Toxic
| Article | Year |
|---|---|
EP2 receptor agonist ONO-AE1-259-01 attenuates pentylenetetrazole- and pilocarpine-induced seizures but causes hippocampal neurotoxicity.
Topics: Animals; Anticonvulsants; Dinoprostone; Hippocampus; Male; Mice; Neurons; Neurotoxicity Syndromes; P | 2017 |
Synthesis, molecular modeling studies, and anticonvulsant evaluation of novel 1-((2-hydroxyethyl)(aryl)amino)-N-substituted cycloalkanecarboxamides and their acetate esters.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Dru | 2018 |
Ultrasound-assisted synthesis, anticonvulsant activity, and docking study of indole-appended thiazolidin-4-ones.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Drug Design; Electroshock; Indol | 2014 |
Synthesis, physicochemical, and anticonvulsant properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and its 3-methyl analog.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug | 2014 |
Anticonvulsant and Neurotoxicity of Some Novel 1-([1,3,4]thiadiazino[6,5- b]indol-3-yl Semicarbazides.
Topics: Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Electroshock; Male; Mi | 2015 |
N-[(2,6-Dimethylphenoxy)alkyl]aminoalkanols-their physicochemical and anticonvulsant properties.
Topics: Animals; Anticonvulsants; Chemistry Techniques, Synthetic; Disease Models, Animal; Drug Evaluation, | 2015 |
Design, synthesis, anticonvulsant, and antiarrhythmic properties of novel N-Mannich base and amide derivatives of β-tetralinohydantoin.
Topics: Amides; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Disease Models, Animal; Drug Design; Elect | 2016 |
Anticonvulsant and neurotoxicity evaluation of some N(4) phenyl substituted pyridyl semicarbazones.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinica | 2009 |
Synthesis and anticonvulsant activity of new kojic acid derivatives.
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Indicators and Reagents; Magnetic Resonance Spe | 2010 |
Synthesis and anticonvulsant activity of some 2/3-benzoylaminopropionanilide derivatives.
Topics: Acetamides; Anilides; Animals; Anticonvulsants; Benzoates; Convulsants; Electroshock; Injections, Su | 2012 |
Synthesis and evaluation of anticonvulsant activities of some bis Mannich bases and corresponding piperidinols.
Topics: Animals; Anticonvulsants; Convulsants; Cyclization; Drug Design; Electroshock; Indicators and Reagen | 2002 |
Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial?
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Brain; Chromatography, Liquid; Disease Models, Anima | 2003 |
Anticonvulsant activity of Schiff bases of isatin derivatives.
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Female; Isatin; Lethal Dose 50; Magnetic Resona | 2004 |
Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Clonazepam; Disease Models, Animal; Drug Interactions; D | 2004 |
Assessment of neurotoxicity induced by oral administration of chlordecone (Kepone) in the mouse.
Topics: Animals; Body Weight; Chlordecone; Convulsants; Dose-Response Relationship, Drug; Drinking; Eating; | 1981 |
Synthesis and anticonvulsant activity of some new hexahydropyrimidine-2,4-dione derivatives.
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Indicators and Reagents; Injections, Intraperit | 2005 |
Synthesis of and pharmacological studies on the antidepressant and anticonvulsant activities of some 1,3,5-trisubstituted pyrazolines.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Convulsants; Electroshock; Indicators and Reagents; | 2005 |
Synthesis and studies on antidepressant and anticonvulsant activities of some 3-(2-furyl)-pyrazoline derivatives.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Convulsants; Electroshock; Furans; Magnetic Resonan | 2007 |
Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis.
Topics: Animals; Anticonvulsants; Brain Chemistry; Clonazepam; Dioxolanes; Disease Models, Animal; Drug Inte | 2006 |
Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy.
Topics: Acetamides; Animals; Anticonvulsants; Bicuculline; Cobalt; Convulsants; Electroshock; Epilepsies, Pa | 2007 |
Evaluation of anticonvulsant activities of bis(3-aryl-3-oxo-propyl) ethylamine hydrochlorides and 4-aryl-3-arylcarbonyl-1-ethyl-4-piperidinol hydrochlorides.
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Elements; Ethylamines; Indicators and Reagents; | 2007 |
Anticonvulsant characteristics of pyridoxyl-gamma-aminobutyrate, PL-GABA.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Drug Tolerance; Electrophysiology; | 2008 |
Higher ketogenic diet ratios confer protection from seizures without neurotoxicity.
Topics: 3-Hydroxybutyric Acid; Animals; Basal Metabolism; Behavior, Animal; Convulsants; Diet; Dietary Fats; | 2000 |
An observational study on neurobehavioural effects of acute oxydemeton-methyl (insecticide and acaricide) exposure in rats.
Topics: Animals; Barbital; Behavior, Animal; Convulsants; Electroshock; Exploratory Behavior; Female; Hypnot | 2000 |