Page last updated: 2024-11-08

pentylenetetrazole and Eclampsia

pentylenetetrazole has been researched along with Eclampsia in 7 studies

Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.

Eclampsia: Onset of HYPERREFLEXIA; SEIZURES; or COMA in a previously diagnosed pre-eclamptic patient (PRE-ECLAMPSIA).

Research Excerpts

ExcerptRelevanceReference
"Our findings indicate that the administration of nicotine may attenuate microglial activity and increase eclampsia-like seizure threshold in rat hippocampus through the α7 nicotinic receptor."7.83Nicotine increases eclampsia-like seizure threshold and attenuates microglial activity in rat hippocampus through the α7 nicotinic acetylcholine receptor. ( Bao, J; Han, X; Li, X; Liu, H; Liu, Y; Thakur, M; Ye, A, 2016)
"Eclampsia is characterized by high morbidity and mortality wordwide."5.51Magnesium sulfate attenuates brain edema by lowering AQP4 expression and inhibits glia-mediated neuroinflammation in a rodent model of eclampsia. ( Li, X; Liu, H; Yang, Y, 2019)
"Here, we hypothesized severe preeclampsia is a state of increased seizure susceptibility due to blood-brain barrier (BBB) disruption and neuroinflammation that lowers seizure threshold."5.40Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia. ( Chan, SL; Cipolla, MJ; Johnson, AC; LaMarca, B; Moseley, J; Nagle, KJ; Tremble, SM, 2014)
"Our findings indicate that the administration of nicotine may attenuate microglial activity and increase eclampsia-like seizure threshold in rat hippocampus through the α7 nicotinic receptor."3.83Nicotine increases eclampsia-like seizure threshold and attenuates microglial activity in rat hippocampus through the α7 nicotinic acetylcholine receptor. ( Bao, J; Han, X; Li, X; Liu, H; Liu, Y; Thakur, M; Ye, A, 2016)
"Reversible posterior leukoencephalopathy syndrome (RPLS) is a clinical-imaging syndrome as well as a critical maternal complication."1.56Contribution of excess inflammation to a possible rat model of eclamptic reversible posterior leukoencephalopathy syndrome induced by lipopolysaccharide and pentylenetetrazol: A preliminary study. ( Chen, D; Fang, X; Liang, Y; Liu, Y; Xie, M; Zhang, W, 2020)
"Eclampsia is characterized by high morbidity and mortality wordwide."1.51Magnesium sulfate attenuates brain edema by lowering AQP4 expression and inhibits glia-mediated neuroinflammation in a rodent model of eclampsia. ( Li, X; Liu, H; Yang, Y, 2019)
"Eclampsia is a poorly understood but potentially fatal complication of pregnancy."1.40Decreased seizure threshold in an eclampsia-like model induced in pregnant rats with lipopolysaccharide and pentylenetetrazol treatments. ( Brennecke, SP; Di, X; Hu, B; Huang, Q; Liu, H; Liu, L, 2014)
"Here, we hypothesized severe preeclampsia is a state of increased seizure susceptibility due to blood-brain barrier (BBB) disruption and neuroinflammation that lowers seizure threshold."1.40Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia. ( Chan, SL; Cipolla, MJ; Johnson, AC; LaMarca, B; Moseley, J; Nagle, KJ; Tremble, SM, 2014)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19902 (28.57)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (57.14)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Fang, X1
Liang, Y1
Chen, D1
Liu, Y2
Xie, M1
Zhang, W1
Li, X2
Liu, H3
Yang, Y1
Huang, Q1
Liu, L1
Hu, B1
Di, X1
Brennecke, SP1
Johnson, AC1
Tremble, SM1
Chan, SL1
Moseley, J1
LaMarca, B1
Nagle, KJ1
Cipolla, MJ1
Han, X1
Bao, J1
Ye, A1
Thakur, M1
GEISER-RAUCH, D1
Browne, TR1
Penry, JK1

Reviews

1 review available for pentylenetetrazole and Eclampsia

ArticleYear
Benzodiazepines in the treatment of epilepsy. A review.
    Epilepsia, 1973, Volume: 14, Issue:3

    Topics: Adult; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Disease Models, Animal; Eclampsia; Elec

1973

Other Studies

6 other studies available for pentylenetetrazole and Eclampsia

ArticleYear
Contribution of excess inflammation to a possible rat model of eclamptic reversible posterior leukoencephalopathy syndrome induced by lipopolysaccharide and pentylenetetrazol: A preliminary study.
    Cytokine, 2020, Volume: 135

    Topics: Animals; Astrocytes; Blood Pressure; Blood-Brain Barrier; Brain; Disease Models, Animal; Eclampsia;

2020
Magnesium sulfate attenuates brain edema by lowering AQP4 expression and inhibits glia-mediated neuroinflammation in a rodent model of eclampsia.
    Behavioural brain research, 2019, 05-17, Volume: 364

    Topics: Animals; Aquaporin 4; Astrocytes; Brain Edema; CA3 Region, Hippocampal; Cytokines; Disease Models, A

2019
Decreased seizure threshold in an eclampsia-like model induced in pregnant rats with lipopolysaccharide and pentylenetetrazol treatments.
    PloS one, 2014, Volume: 9, Issue:2

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Eclampsia; Female; Humans; Lipopolysaccharides; Ma

2014
Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia.
    PloS one, 2014, Volume: 9, Issue:11

    Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Convulsants; Diet, High-Fat; Disease Models, Anima

2014
Nicotine increases eclampsia-like seizure threshold and attenuates microglial activity in rat hippocampus through the α7 nicotinic acetylcholine receptor.
    Brain research, 2016, 07-01, Volume: 1642

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Astrocytes; Blood Pressure; CA1 Region, Hippocampa

2016
[Cardiazol-activated EEG in former eclampsia patients].
    Schweizerische medizinische Wochenschrift, 1958, Jul-12, Volume: 88, Issue:28

    Topics: Eclampsia; Electroencephalography; Female; Humans; Pentylenetetrazole; Pregnancy

1958