pentylenetetrazole has been researched along with Dystonia in 7 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Dystonia: An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pathophysiology of idiopathic dystonias is still unknown, but it is regarded as a basal ganglia disorder." | 1.36 | Effects of pharmacological entopeduncular manipulations on idiopathic dystonia in the dt(sz) mutant hamster. ( Hamann, M; Kreil, A; Richter, A; Sander, SE, 2010) |
| "The underlying mechanisms of idiopathic dystonias are poorly understood." | 1.31 | Effects of striatal injections of GABA(A) receptor agonists and antagonists in a genetic animal model of paroxysmal dystonia. ( Hamann, M; Richter, A, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mo, J | 1 |
| Wang, B | 1 |
| Zhu, X | 1 |
| Wu, X | 1 |
| Liu, Y | 1 |
| Hamann, M | 3 |
| Sander, SE | 1 |
| Kreil, A | 1 |
| Richter, A | 5 |
| Fedrowitz, M | 1 |
| Rehders, JH | 1 |
| Gernert, M | 3 |
| Löscher, W | 3 |
| Fredow, G | 1 |
7 other studies available for pentylenetetrazole and Dystonia
| Article | Year |
|---|---|
PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by influencing synaptic function in the primary motor cortex of rats.
Topics: Animals; Disease Models, Animal; Dystonia; Female; Male; Membrane Proteins; Motor Cortex; Nerve Tiss | 2019 |
Effects of pharmacological entopeduncular manipulations on idiopathic dystonia in the dt(sz) mutant hamster.
Topics: Animals; Animals, Newborn; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dru | 2010 |
Effects of locally administered pentylenetetrazole on nigral single unit activity and severity of dystonia in a genetic model of paroxysmal dystonia.
Topics: Action Potentials; Animals; Behavior, Animal; Convulsants; Cricetinae; Disease Models, Animal; Dysto | 2002 |
Subconvulsive dose of pentylenetetrazole increases the firing rate of substantia nigra pars reticulata neurons in dystonic but not in nondystonic hamsters.
Topics: Animals; Cricetinae; Dystonia; Electrophysiology; Evoked Potentials; Mesocricetus; Neurons; Pentylen | 1999 |
In vivo extracellular electrophysiology of pallidal neurons in dystonic and nondystonic hamsters.
Topics: Action Potentials; Animals; Convulsants; Cricetinae; Dystonia; GABA Agonists; Globus Pallidus; Mesoc | 1999 |
Effects of striatal injections of GABA(A) receptor agonists and antagonists in a genetic animal model of paroxysmal dystonia.
Topics: Animals; Bicuculline; Binding Sites; Corpus Striatum; Cricetinae; Dystonia; Female; Flumazenil; Flur | 2002 |
Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia.
Topics: Animals; Baclofen; Carbamazepine; Cricetinae; Diazepam; Disease Models, Animal; Dystonia; gamma-Amin | 1991 |