pentylenetetrazole has been researched along with Disease Models, Animal in 1039 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study was conducted to evaluate the effect of probiotic supplementation on pentylenetetrazole (PTZ)-induced seizures in rats." | 8.31 | Electrophysiological, histopathological, and biochemical evaluation of the protective effect of probiotic supplementation against pentylenetetrazole-induced seizures in rats. ( Akin, AT; Aygun, H; Karabulut, D; Kızılaslan, N; Sumbul, O, 2023) |
| "This study aimed to examine the relationship between epilepsy and COX/5-LOX inflammation pathways in the penicillin and pentylenetetrazole (PTZ)-induced epilepsy models." | 8.31 | An involvement of COX and 5-LOX pathways in the penicillin- and pentylenetetrazole (PTZ)-induced epilepsy models. ( Taşdemir, A; Taskiran, M, 2023) |
| "To investigate the effects of different doses of esculetin on epileptiform activity, behavioral seizures, memory impairment, and cortical and hippocampal NF-κB, as a mediator of pro-inflammatory gene induction, and pro-inflammatory cytokines in penicillin- and pentylenetetrazole(PTZ)-induced seizure models in rats." | 8.31 | Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats. ( Ankarali, H; Baranoglu Kilinc, Y; Danis, A; Hanci, F; Kilinc, E; Torun, IE, 2023) |
| " We aimed to evaluate the effect of quercetin on pentylenetetrazole- (PTZ-) induced seizures in male mice focusing on its possible anti-neuroinflammatory and anti-oxidative stress." | 8.31 | Anticonvulsant effect of quercetin in pentylenetetrazole (PTZ)-induced seizures in male mice: The role of anti-neuroinflammatory and anti-oxidative stress. ( Amini-Khoei, H; Korani, MS; Lorigooini, Z; Rahimi-Madiseh, M; Tahmasebi Dehkordi, H; Tavakoli, Z, 2023) |
| " Here, we evaluated its neuroprotective effects at different doses (100 and 200 mg/kg) against pentylenetetrazole (PTZ)-induced seizures." | 8.31 | Neuroprotective effects of Royal Jelly (RJ) against pentylenetetrazole (PTZ)-induced seizures in rats by targeting inflammation and oxidative stress. ( Dolatshahi, M; Hashemi, P; Karimpour, S; Nazarinia, D, 2023) |
| "A common way to investigate epilepsy and the effect of antiepileptic pharmaceuticals is to analyze the movement patterns of zebrafish larvae treated with different convulsants like pentylenetetrazol (PTZ), pilocarpine, etc." | 8.31 | A comparative study to optimize experimental conditions of pentylenetetrazol and pilocarpine-induced epilepsy in zebrafish larvae. ( Aly, N; Budan, F; Dittrich, B; Gorbe, A; Jin, M; Sik, A; Szentpeteri, JL; Szep, D, 2023) |
| " Here, we conducted present study to evaluate its neuroprotective effects against pentylenetetrazole (PTZ)-induced seizures in rats." | 8.31 | (-)-α-bisabolol exerts neuroprotective effects against pentylenetetrazole-induced seizures in rats by targeting inflammation and oxidative stress. ( Hashemi, P; Moslehi, A; Nazarinia, D, 2023) |
| " In this regard, the effects of oxaprozin (OXP) (a nonsteroidal anti-inflammatory drug) on the experimental model of seizure and memory impairment caused by seizures in rats were investigated in the present study." | 8.12 | Nonsteroidal Anti-inflammatory Drug Oxaprozin is Beneficial Against Seizure-induced Memory Impairment in an Experimental Model of Seizures in Rats: Impact On Oxidative Stress and Nrf2/HO-1 Signaling Pathway. ( Bananej, M; Khatami, P; Khosravi, M; Mirazi, N, 2022) |
| "Pentylenetetrazole (PTZ)-induced kindling is an animal model for studying human temporal lobe epilepsy (TLE), which is characterized by alterations of hippocampal neurons and memory." | 8.12 | Protective Effects of Intranasally Administrated Oxytocin-Loaded Nanoparticles on Pentylenetetrazole-Kindling Epilepsy in Terms of Seizure Severity, Memory, Neurogenesis, and Neuronal Damage. ( Emik, S; Sahin, H; Senturk, GE; Yucel, O, 2022) |
| " Here we examine the effects of valproic acid (VA) plus 4-phenylbutyric acid (4-PBA) on abnormal electrical brain activity, ER stress and apoptosis in acute seizures induced by pentylenetetrazole (PTZ)." | 8.12 | 4-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole. ( Amanvermez, R; Arslan, G; Gün, S; Rzayev, E; Tiryaki, ES, 2022) |
| " In this study, we investigated the possible beneficial effects of lasmiditan and sumatriptan against post-stroke seizures in mice and explored underlying mechanisms in their effects." | 8.12 | Neuroprotective effects of Lasmiditan and Sumatriptan in an experimental model of post-stroke seizure in mice: Higher effects with concurrent opioid receptors or K ( Amanlou, A; Dehpour, AR; Ejtemaei-Mehr, S; Eslami, F; Ghasemi, M; Rahimi, N; Rashidian, A; Shayan, M; Solaimanian, S, 2022) |
| "In spite of use of cannabidiol (CBD), a non-psychoactive cannabinoid, in pediatric patients with epilepsy, preclinical studies on its effects in immature animals are very limited." | 8.02 | Anticonvulsive Effects and Pharmacokinetic Profile of Cannabidiol (CBD) in the Pentylenetetrazol (PTZ) or N-Methyl-D-Aspartate (NMDA) Models of Seizures in Infantile Rats. ( Hložek, T; Kubová, H; Mareš, P; Páleníček, T; Uttl, L, 2021) |
| " In the pharmacodynamic interaction study, seizures were induced using pentylenetetrazole (PTZ) (60 mg/kg, i." | 8.02 | Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats. ( Agarwal, A; Arora, R; Ganeshan N, S; Gupta, YK; Kaleekal, T; Kumar, R; Sarangi, SC, 2021) |
| " The seizures were induced with pentylenetetrazole (PTZ) intraperitoneally at 170 mg/kg, and diazepam (DZP) was used as the control anticonvulsant (2 mg/kg, oral); PA was tested at 10, 50, and 100 mg/kg orally." | 8.02 | Perillyl alcohol decreases the frequency and severity of convulsive-like behavior in the adult zebrafish model of acute seizures. ( Borges, RS; Carvalho, JCT; da Silva Hage-Melim, LI; de Melo, EL; Hu, X; Matias Pereira, AC; Sánchez-Ortíz, BL, 2021) |
| " In the pentylenetetrazole-induced seizure model, 1, 5, or 10 mg/kg vortioxetine demonstrated a significant dose-dependent decrease in mean spike frequency, an increase in the latency to minor and major seizures, and a decrease in total duration of major seizure and convulsion stage." | 8.02 | Vortioxetine increases absence-like seizures in WAG/Rij rats but decreases penicillin- and pentylenetetrazole-induced seizures in Wistar rats. ( Aygun, H; Ayyildiz, M, 2021) |
| " The study looked at how the thiamine supplement impacted pentylenetetrazole (PTZ)-induced seizures in rats and pentylenetetrazole-induced neurotoxicity in the SH-SY5Y cell line." | 8.02 | The modulator action of thiamine against pentylenetetrazole-induced seizures, apoptosis, nitric oxide, and oxidative stress in rats and SH-SY5Y neuronal cell line. ( Ergul, M; Taskiran, AS, 2021) |
| " citratus essential oil (EO) and hydroalcoholic extract (E1) from its leaves, as well as of its related compounds citral (CIT) and geraniol (GER) against the effects of pentylenetetrazole (PTZ) induced seizures in zebrafish (Danio rerio)." | 8.02 | Cymbopogon citratus (DC.) Stapf, citral and geraniol exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures in zebrafish. ( Hacke, ACM; Marques, JA; Miyoshi, E; Pereira, RP, 2021) |
| "A model of acute epilepsy in mice was established using the Pentylenetetrazol (PTZ) ignition method to evaluate the effects of Rhein on the duration and latency of convulsions, and the number and severity of seizures." | 8.02 | Rhein attenuates PTZ‑induced epilepsy and exerts neuroprotective activity via inhibition of the TLR4-NFκB signaling pathway. ( Cao, J; Li, X; Yang, J; Yu, L; Yu, W, 2021) |
| " We investigated effects of long-term probiotics supplementation on epileptic seizures, and inflammatory and oxidant/antioxidant biomarkers in a pentylenetetrazole(PTZ)-induced seizure model in rats." | 8.02 | Protective effects of long-term probiotic mixture supplementation against pentylenetetrazole-induced seizures, inflammation and oxidative stress in rats. ( Ankarali, H; Ankarali, S; Ayhan, D; Cetinkaya, A; Kilinc, E; Torun, IE, 2021) |
| "The goal of our study was to examine the long-term effect of vigabatrin (VGB), a γ-aminobutyric acid aminotransferase (GABA-AT) inhibitor on clonazepam (CLO), ethosuximide (ETX) and valproate (VPA) anticonvulsive activity against pentylenetetrazole (PTZ)-induced seizures in mice." | 7.96 | Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration. ( Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ, 2020) |
| " The present study was designed to evaluate the effect of arbutin supplementation on seizures behavior, memory performance, glial activation, release of inflammatory factors and neuroprotection in pentylenetetrazole-induced kindling model." | 7.91 | Arbutin attenuates cognitive impairment and inflammatory response in pentylenetetrazol-induced kindling model of epilepsy. ( Ahmadian, SR; Ghasemi-Kasman, M; Pouramir, M; Sadeghi, F, 2019) |
| "The effects of edaravone against pentylenetetrazole (PTZ)-induced epilepsy in male albino rats were investigated." | 7.91 | Edaravone acts as a potential therapeutic drug against pentylenetetrazole-induced epilepsy in male albino rats by downregulating cyclooxygenase-II. ( Liu, LM; Lu, Y; Wang, N; Wang, WP, 2019) |
| " The aim of this study was to evaluate the effects of corilagin, an ellagitannin extracted from medicinal plants, on the frequency of seizures and cognitive function in a rat model of chronic epilepsy." | 7.88 | Corilagin Reduces the Frequency of Seizures and Improves Cognitive Function in a Rat Model of Chronic Epilepsy. ( Chang, LY; Wei, LL; Yu, H; Yu, X; Zhou, T, 2018) |
| " Hence, thalidomide (100, 200 and 400 mg/kg) was herein administered to mice to evaluate possible protection against seizures induced by the systemic administration of neurotoxins: 10 mg/kg of 4-aminopyridine (4-AP), 90 mg/kg of pentylenetetrazol (PTZ), or 380 mg/kg of pilocarpine." | 7.88 | Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice. ( Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER, 2018) |
| " All rats except those from the sham group were treated with PTZ to establish temporal lobe epilepsy (TLE) models, whereas the P38 MAPK inhibitor SB 203580 was given to the inhibitor group." | 7.85 | P38 MAPK pathway mediates cognitive damage in pentylenetetrazole-induced epilepsy via apoptosis cascade. ( Huang, Q; Huang, Y; Liao, Y; Liu, X; Ma, M; Wei, X; Wu, Y, 2017) |
| " This study aimed to examine the relationship of ADO with the mammalian target of rapamycin (mTOR) in a Wistar rat model of pentylenetetrazole (PTZ)-induced acute status epilepticus." | 7.85 | Attenuation of pentylenetrazole-induced acute status epilepticus in rats by adenosine involves inhibition of the mammalian target of rapamycin pathway. ( Chen, J; Han, T; Liu, X; Su, L; Wang, Y; Zang, K, 2017) |
| " Ferulic acid is a phenolic phytochemical with antioxidant and neuroprotective properties that prompted us to evaluate its therapeutic potential in epilepsy which is usually associated with oxidative stress and cognitive decline." | 7.85 | Ferulic acid exhibits antiepileptogenic effect and prevents oxidative stress and cognitive impairment in the kindling model of epilepsy. ( Arbabi, E; Atyabi, F; Dinarvand, R; Hassanzadeh, P, 2017) |
| "In this study, the effects of levosimendan on seizure susceptibility was studied by PTZ-induced seizures model in mice." | 7.85 | Levosimendan exerts anticonvulsant properties against PTZ-induced seizures in mice through activation of nNOS/NO pathway: Role for K ( Aleyasin, AR; Amini-Khoei, H; Amiri, S; Dehpour, AR; Ghasemi, K; Gooshe, M; Mojahedi, P; Tabaeizadeh, M; Vafaei, A; Yousefi, F, 2017) |
| " Here, we found that gastrodin ameliorated pentylenetetrazole (PTZ)-induced epileptic seizures with improvement of the electroencephalographic pattern in mice." | 7.85 | Gastrodin Attenuates Pentylenetetrazole-Induced Seizures by Modulating the Mitogen-Activated Protein Kinase-Associated Inflammatory Responses in Mice. ( Chen, L; Liu, X; Qu, M; Wang, H, 2017) |
| " We investigated the effects of oleuropein on pentylenetetrazole (PTZ)-induced seizures in male NMRI mice, with diazepam as the standard drug." | 7.85 | Effects of oleuropein on pentylenetetrazol-induced seizures in mice: involvement of opioidergic and nitrergic systems. ( Dehpour, AR; Delfan, B; Motamed-Gorji, N; Rahimi, N, 2017) |
| " Based on previous results in rodents, we have here examined the effects of artificial sweetener sodium cyclamate and antimicrobial agent sodium propylparaben on a model of pentylenetetrazole (PTZ)-induced seizures in zebrafish." | 7.85 | Anticonvulsant effect of sodium cyclamate and propylparaben on pentylenetetrazol-induced seizures in zebrafish. ( Bernabeu, R; Bruno-Blanch, L; Otero, S; Pisera-Fuster, A; Talevi, A, 2017) |
| " Seizures were induced with one of Pentelyntetrazole (PTZ), 4-Aminopyridine (AP) and Strychnine (STR)." | 7.85 | Antiseizure Effects of Ketogenic Diet on Seizures Induced with Pentylenetetrazole, 4-Aminopyridine and Strychnine in Wistar Rats. ( Desalu, OO; Kolo, PM; Olarinoye, JK; Olatunji, LA; Sanya, EO; Soladoye, AO, 2017) |
| " The present study was designed to investigate synergistic anticonvulsant effects of pregabalin with amlodipine on acute seizure model of epilepsy in mice." | 7.85 | Synergistic anticonvulsant effects of pregabalin and amlodipine on acute seizure model of epilepsy in mice. ( Khan, RA; Qureshi, IH; Riaz, A; Siddiqui, AA, 2017) |
| "It has been demonstrated that the zebrafish model of pentylenetetrazole (PTZ)-evoked seizures and the well-established rodent models of epilepsy are similar pertaining to behavior, electrographic features, and c-fos expression." | 7.83 | Indomethacin treatment prior to pentylenetetrazole-induced seizures downregulates the expression of il1b and cox2 and decreases seizure-like behavior in zebrafish larvae. ( Barbalho, PG; Lopes-Cendes, I; Maurer-Morelli, CV, 2016) |
| "Pentylenetetrazole (PTZ), γ-aminobutyrate (GABA) antagonist, is a convulsant drug, known to induce anxiety and seizures in zebrafish." | 7.83 | Anxiety-related behavioral responses of pentylenetetrazole-treated zebrafish larvae to light-dark transitions. ( Guo, N; Ji, Y; Li, Q; Lin, J; Liu, X; Peng, X; Yang, X; Zhang, Y; Zhu, Y, 2016) |
| "Our findings indicate that the administration of nicotine may attenuate microglial activity and increase eclampsia-like seizure threshold in rat hippocampus through the α7 nicotinic receptor." | 7.83 | Nicotine increases eclampsia-like seizure threshold and attenuates microglial activity in rat hippocampus through the α7 nicotinic acetylcholine receptor. ( Bao, J; Han, X; Li, X; Liu, H; Liu, Y; Thakur, M; Ye, A, 2016) |
| " In this study we assessed the susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice with genetically altered uric acid levels by targeting urate oxidase, which is the enzyme responsible for uric acid breakdown." | 7.83 | Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice. ( Boon, P; Carrette, E; Delbeke, J; Glorieux, G; Larsen, LE; Portelli, J; Raedt, R; Sprengers, M; Thyrion, L; Van Lysebettens, W; Vonck, K, 2016) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 7.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| " We aim to reveal the anticonvulsant effects of dexketoprofen in pentylenetetrazol (PTZ)-induced seizures in rats." | 7.81 | Inhibitor effect of dexketoprofen in rat model of pentylenetetrazol-induced seizures. ( Aksoy, D; Erbaş, O; Solmaz, V, 2015) |
| "Influence of ozone's treatments in mice submitted to PTZ-induced seizures was studied." | 7.81 | Ozone protective effects against PTZ-induced generalized seizures are mediated by reestablishment of cellular redox balance and A1 adenosine receptors. ( Cedeño, RI; Fernández, OS; Mallok, A; Pérez, AF; Soto, MT; Vaillant, JD; Viart, Mde L; Viebahn-Hänsler, R, 2015) |
| "All the control rats presented generalized tonic-clonic seizures after the administration of pentylenetetrazole." | 7.81 | Anticonvulsant effects of mefloquine on generalized tonic-clonic seizures induced by two acute models in rats. ( Ballesteros-Zebadúa, P; Franco-Pérez, J; Manjarrez-Marmolejo, J, 2015) |
| " In this study, we investigated the expression of JIP3 in temporal lobe epilepsy (TLE) and in a kainic acid (KA)-induced mouse model of epileptic seizures, and determined whether down-regulation of JIP3 can decrease susceptibility to seizures and neuron damage induced by KA." | 7.81 | Effects of JIP3 on epileptic seizures: Evidence from temporal lobe epilepsy patients, kainic-induced acute seizures and pentylenetetrazole-induced kindled seizures. ( Chen, X; Chen, Y; Cheng, L; Deng, W; Li, J; Li, Y; Lü, Y; Mi, X; Wang, N; Wang, X; Wang, Z; Xu, X; Zhang, Y, 2015) |
| "The effects of coadministration of melatonin and theanine (Mel/Thea) on pentylenetetrazole (PTZ)-induced seizures and brain tissue oxidative damage were investigated in ovariectomized (OVX) and sham-operated rats." | 7.81 | Effects of melatonin and theanine administration on pentylenetetrazole-induced seizures and brain tissue oxidative damage in ovariectomized rats. ( Choopankareh, S; Hosseini, M; Sadeghnia, HR; Salarinia, R; Shafei, MN; Vafaee, F; Zarepoor, L, 2015) |
| "There is considerable interest in using bumetanide, a chloride importer Na-K-Cl cotransporter antagonist, for treatment of neurological diseases, such as epilepsy or ischemic and traumatic brain injury, that may involve deranged cellular chloride homeostasis." | 7.80 | A novel prodrug-based strategy to increase effects of bumetanide in epilepsy. ( Brandt, C; Brunhofer, G; Erker, T; Feit, PW; Gabriel, M; Kaila, K; Lindfors, J; Löscher, W; Töllner, K; Töpfer, M, 2014) |
| "The aims of this study were to characterize a lamotrigine-resistant kindled model of epilepsy in mice, to study the anticonvulsant effect of carbamazepine (CBZ) and valproic acid (VPA), and to probe into the mechanism for resistance." | 7.80 | Characterization of a lamotrigine-resistant kindled model of epilepsy in mice: evaluation of drug resistance mechanisms. ( Mehndiratta, M; Pillai, KK; Singh, E, 2014) |
| " This study was designed to investigate whether acute or subchronic treatment with coenzyme Q10 altered the seizures induced by pentylenetetrazole or electroshock in mice." | 7.80 | The effects of coenzyme Q10 on seizures in mice: the involvement of nitric oxide. ( Moezi, L; Mousavi, Z; Sattarinezhad, E; Shafaroodi, H; Sheikhnouri, K, 2014) |
| " Pentylenetetrazole (PTZ)-kindled and spontaneous model of epilepsy (EL) mice were used as models of chemically induced and spontaneous epilepsy, respectively." | 7.80 | Pharmacoproteomics-based reconstruction of in vivo P-glycoprotein function at blood-brain barrier and brain distribution of substrate verapamil in pentylenetetrazole-kindled epilepsy, spontaneous epilepsy, and phenytoin treatment models. ( Ohtsuki, S; Terasaki, T; Uchida, Y, 2014) |
| "The present study was aimed to investigate the potential beneficial effect of curcumin, a polyphenol with pleiotropic properties, on mitochondrial dysfunctions, oxidative stress and cognitive deficits in a kindled model of epilepsy." | 7.80 | Curcumin supplementation improves mitochondrial and behavioral deficits in experimental model of chronic epilepsy. ( Bal, A; Kaur, H; Sandhir, R, 2014) |
| "These data indicate that MSCs were superior to gabapentin in ameliorating PTZ-induced epileptogenesis and verified the potential use of MSCs in seizure control, motor and cognitive impairments, oxidative stress, and the impairing GABA level in experimentally induced epilepsy." | 7.80 | Effects of intravenous human umbilical cord blood mesenchymal stem cell therapy versus gabapentin in pentylenetetrazole-induced chronic epilepsy in rats. ( Essawy, SS; Ewais, MM; Mohammed, AS; Tawfik, MK, 2014) |
| "Besides the clinical applications of penicillamine, some reports show that use of D-penicillamine (D-pen) has been associated with adverse effects such as seizures." | 7.80 | Effects of D-penicillamine on pentylenetetrazole-induced seizures in mice: involvement of nitric oxide/NMDA pathways. ( Dehpour, AR; Heidary, MR; Javadi-Paydar, M; Jazaeri, F; Rahimi, N; Sadeghzadeh, M, 2014) |
| "Alterations in the NO pathway play an important role in the development of convulsive seizures via the glutamatergic and GABAergic systems in acute pentylenetetrazole (PTZ) seizure animals." | 7.79 | The threshold of pentylenetetrazole-induced convulsive seizures, but not that of nonconvulsive seizures, is controlled by the nitric oxide levels in murine brains. ( Danjo, S; Itoh, K; Miyai, A; Nakamura, Y; Watanabe, M, 2013) |
| " perforatum was compared with standard antidepressants using animal models of depression such as forced swim test (FST), yohimbine induced lethality test, pnetylenetetrazole (PTZ) induced convulsion and locomotor activity tests." | 7.79 | Behavioral profile of Hypericum perforatum (St. John's Wort) extract. A comparison with standard antidepressants in animal models of depression. ( Bukhari, IA; Dar, A, 2013) |
| "The anticonvulsant effect of dicholine succinate (DCS), a neuronal insulin sensitizer, has been studied on two models of primary generalized epilepsy induced by corazole and maximal electroshock (ME) in mice." | 7.79 | [Anticonvulsant effect of dicholine succinate on primary generalized epilepsy model in mice]. ( Pomytkin, IA; Rychikhin, VM; Sariev, AK, 2013) |
| " (MQ) in maximal electroshock (MES) and pentylenetetrazole (PTZ) induced rat models of epilepsy." | 7.79 | Evaluation of anti-epileptic property of Marsilea quadrifolia Linn. in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy. ( Avinash, H; Chandrashekar, BR; Mukunda, N; Naduvil Narayanan, S; Nayak, BS; Raghavendra Rao, K; Sadhana, N; Satish Kumar, MC; Snehunsu, A; Vijay Kapgal, K, 2013) |
| " Thus, this study was carried out to evaluate the acute effect of liposome-entrapped curcumin on increasing current electroshock seizures (ICES) test, pentylenetetrazole (PTZ)-induced seizures, and status epilepticus in mice." | 7.79 | Liposomal formulation of curcumin attenuates seizures in different experimental models of epilepsy in mice. ( Agarwal, NB; Agarwal, NK; Jain, S; Mediratta, PK; Nagpal, D; Sharma, KK, 2013) |
| "We aimed to reveal the anti-convulsant effects of oxytocin (OT) in pentylenetetrazol (PTZ)-induced seizures in rats." | 7.79 | Oxytocin inhibits pentylentetrazol-induced seizures in the rat. ( Bora, S; Erbas, O; Evren, V; Korkmaz, HA; Peker, G; Yılmaz, M, 2013) |
| " We here investigated for the first time the effect of L-theanine intake on seizure susceptibility using acute pilocarpine and pentylenetetrazol (PTZ) mouse models for studying, respectively, limbic seizures or primarily generalized seizures." | 7.79 | L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures. ( Loyens, E; Massie, A; Michotte, Y; Schallier, A; Smolders, I; Van Liefferinge, J; Vermoesen, K, 2013) |
| "Taken together, sub-chronic pioglitazone treatment exerts anti-convulsant effects in intravenous and intraperitoneal pentylenetetrazole-induced seizures of mice probably through induction of constitutive nitric oxide synthase." | 7.78 | Sub-chronic treatment with pioglitazone exerts anti-convulsant effects in pentylenetetrazole-induced seizures of mice: The role of nitric oxide. ( Dehpour, AR; Ghorbani, H; Hassanipour, M; Hassanpour, S; Moezi, L; Shafaroodi, H; Zaeri, M, 2012) |
| "), its effects on seizures, EEG epileptiform activity and EEG amplitude increases induced by two convulsive agents were evaluated and compared with the effects of carbamazepine." | 7.78 | The antidepressant sertraline prevents the behavioral and EEG changes induced in two animal models of seizures. ( Aldana, BI; Gómez, CD; Nekrassov, V; Sitges, M, 2012) |
| " We showed previously that hypoxia-induced seizures in a neonatal rat model induce rapid phosphorylation of serine-831 (S831) and Serine 845 (S845) sites of the AMPA receptor GluR1 subunit and later neuronal hyperexcitability and epilepsy, suggesting that seizure-induced posttranslational modifications may represent a novel therapeutic target." | 7.78 | Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures. ( Fitzgerald, EF; Huganir, RL; Hunganir, RL; Jensen, FE; Klein, PM; Rakhade, SN; Sun, H; Zhou, C, 2012) |
| "Wuling mycelia can delay the kindling and ameliorate the ability of learning in rats with pentylenetetrazole-induced epilepsy and the enhancement of neuronal histamine activity may be one of possible mechanisms." | 7.78 | [Effects of Wuling mycelia on pentylenetetrazole-induced epilepsy in rats]. ( Chen, GF; Hu, XY; Ren, GL; Zhang, LS, 2012) |
| "The effects of the halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine (3,5-DBr-D: -Tyr) were studied in rat models of stroke and epileptic seizures caused by middle cerebral artery occlusion (MCAo) through respective intracerebral injection of endothelin-1 (ET-1) and intraperitoneal (i." | 7.77 | Halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine produces beneficial effects in experimental stroke and seizures. ( Cao, W; Glushakov, A; Martynyuk, AE; Mecca, AP; Seubert, CN; Shah, HP; Shi, P; Sumners, C, 2011) |
| "The aim of present study was to examine the effects of the ethyl acetate fraction (EAF) from Platonia insignis on lipid peroxidation level, nitrite formation, and superoxide dismutase and catalase activities in rat striatum prior to pilocarpine-induced seizures as well as to explore its anticonvulsant activity in adult rats prior to pentylenetetrazole (PTZ)- and picrotoxin (PIC)-induced seizures." | 7.77 | Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models. ( Citó, AM; de Almeida, AA; de Freitas, RM; Júnior, JS; Saffi, J; Tomé, Ada R, 2011) |
| "In various animals methionine sulfoximine (MSO) induces tonic-clonic seizures resembling the most striking form of human epilepsies." | 7.76 | Selection of two lines of mice based on latency to onset of methionine sulfoximine seizures. ( Cloix, JF; Hévor, T; Martin, B; Tahi, Z, 2010) |
| " Similar to lithium, agmatine plays a protective role in the central nervous system against seizures and has been reported to enhance the effect of different antiepileptic agents." | 7.76 | Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway. ( Bahremand, A; Dehpour, AR; Ghasemi, A; Ghasemi, M; Hedayat, T; Khodadad, TK; Payandemehr, B; Rahimian, R; Ziai, P, 2010) |
| " In the present study, using a model of clonic seizures induced with pentylenetetrazole (PTZ) in male Swiss mice, we investigated whether there is any interaction between lithium and either calcium channel blockers (CCBs: nifedipine, verapamil, and diltiazem) or N-methyl-D-aspartate (NMDA) receptor antagonists (ketamine and MK-801) in modulating seizure threshold." | 7.76 | Voltage-dependent calcium channel and NMDA receptor antagonists augment anticonvulsant effects of lithium chloride on pentylenetetrazole-induced clonic seizures in mice. ( Bahremand, A; Dehpour, AR; Ghasemi, A; Ghasemi, M; Heydarpour, P; Meskar, H; Nazarbeiki, S; Shafaroodi, H; Talab, SS; Ziai, P, 2010) |
| " The effects of the protein synthesis inhibitor cycloheximide (CHX) were examined on the expression and reconsolidation of pentylenetetrazole (PTZ) - induced kindled seizures and for comparative purposes, on the reconsolidation of conditioned fear response (conditioned freezing)." | 7.76 | The differential effects of protein synthesis inhibition on the expression and reconsolidation of pentylenetetrazole kindled seizures. ( Bidziński, A; Lehner, M; Maciejak, P; Płaźnik, A; Sobolewska, A; Szyndler, J; Turzyńska, D, 2010) |
| " Hence, this study was conducted to evaluate the effect of curcumin against seizures, cognitive impairment and oxidative stress in pentylenetetrazole-induced kindling in rats." | 7.76 | Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model. ( Gupta, P; Gupta, YK; Mehla, J; Reeta, KH, 2010) |
| "In the present study, the effects of tramadol on pentylenetetrazole (PTZ)-induced seizures and involvement of nitric oxide (NO) were assessed in mice." | 7.76 | Involvement of the nitric oxide pathway in the anticonvulsant effect of tramadol on pentylenetetrazole-induced seizures in mice. ( Asghari-Roodsari, A; Dehpour, AR; Javadi-Paydar, M; Khodadad, TK; Lesani, A; Norouzi, A; Shirkhodaei, M, 2010) |
| "Morphine dependence increased a PTZ-induced long-term potentiation (LTP) of the population spike in CA1 in vitro." | 7.75 | Morphine dependence increases the response to a brief pentylenetetrazol administration in rat hippocampal CA1 in vitro. ( Fathollahi, Y; Jafarzadeh, Z; Omrani, A; Salmani, ME; Salmanzadeh, F; Semnanian, S, 2009) |
| " 3,5-DBr-L-Phe was also given as a single bolus prior to pentylenetetrazole (PTZ) injection to induce seizures or prior to the administration of the N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine (MK-801) to cause disruption of prepulse inhibition (PPI) of startle (sensorimotor gating deficit)." | 7.75 | Efficacy of 3,5-dibromo-L-phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit. ( Cao, W; Glushakov, AV; Martynyuk, AE; Mecca, AP; Seubert, CN; Shah, HP; Shi, P; Sumners, C, 2009) |
| "To characterize the type of interactions between vigabatrin (VGB) and tiagabine (TGB) -- two newer antiepileptic drugs influencing GABA-ergic neurotransmitter system, the isobolographic analysis was used in two experimental models of epilepsy: the maximal electroshock seizure threshold (MEST) test and pentylenetetrazole (PTZ)-induced seizures in mice." | 7.74 | Isobolographic characterization of interactions between vigabatrin and tiagabine in two experimental models of epilepsy. ( Czuczwar, SJ; Luszczki, JJ, 2007) |
| " We studied the potential anticonvulsant effect of thalidomide: Different doses of thalidomide were tested against seizures induced by 50 mg/kg or 70 mg/kg of pentylenetetrazole (PTZ); the anticonvulsant effect of thalidomide was also compared with that of valproic acid." | 7.74 | Thalidomide inhibits pentylenetetrazole-induced seizures. ( Calderon, A; Palencia, G; Sotelo, J, 2007) |
| " We have investigated the effects of mirtazapine on pentylenetetrazole (PTZ)- and maximal electroconvulsive shock (MES)-induced seizures in mice." | 7.74 | Mirtazapine does not affect pentylenetetrazole- and maximal electroconvulsive shock-induced seizures in mice. ( Kayir, H; Sezer, Z; Uzbay, TI; Yilmaz, I, 2007) |
| " Pentylenetetrazole (PTZ)-induced seizures were used to evaluate the anticonvulsant effect of drugs." | 7.73 | Modulation of pentylenetetrazole-induced seizures and oxidative stress parameters by sodium valproate in the absence and presence of N-acetylcysteine. ( Pillai, KK; Uma Devi, P; Vohora, D, 2006) |
| " Anticonvulsant effects were evaluated against seizures induced by 14 mg kg(-1) of 4-aminopyridine (4-AP) and by 110 mg kg(-1) of pentylenetetrazole (PTZ), and neurotoxicity by the rotarod test." | 7.72 | Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial? ( Amat, G; Armijo, JA; Cuadrado, A, 2003) |
| "The study investigated the activity of harmane on maximal electroshock seizures (MES) and seizures induced by pentilentetrazole (PTZ) in mice." | 7.72 | Effect of harmane on the convulsive threshold in epilepsy models in mice. ( Aricioglu, F; Berkman, K; Korcegez, E; Yillar, O, 2003) |
| " The aim of this study was to evaluate the profile of interactions between FBM and four conventional antiepileptic drugs (AEDs): clonazepam (CZP), ethosuximide (ESM), phenobarbital (PB), and valproate (VPA), in pentylenetetrazole (PTZ)-induced convulsions in mice, a model of myoclonic seizures in humans." | 7.72 | Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ, 2004) |
| " In the present study, we induced lithium and pilocarpine status epilepticus (SE) in 10-day-old (P10) rats." | 7.71 | Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures. ( Dubé, C; Koning, E; Nehlig, A, 2002) |
| "The anticonvulsive activity of nociceptin, endogenous OP4 receptors agonist was investigated in pentylenetetrazole (PTZ), N-methyl D-aspartic acid (NMDA), bicucculine (BCC) and electrically evoked seizure models of experimental epilepsy." | 7.71 | Nociceptin, OP4 receptor ligand in different models of experimental epilepsy. ( Gustaw, K; Rubaj, A; Sieklucka-Dziuba, M; Zgodzinski, W, 2002) |
| "The effect of trans-resveratrol (resveratrol), a polyphenolic compound with potent antioxidant activity, was investigated against pentylenetetrazole (PTZ) induced seizures in rats." | 7.71 | Protective effect of resveratrol against pentylenetetrazole-induced seizures and its modulation by an adenosinergic system. ( Chaudhary, G; Gupta, YK; Srivastava, AK, 2002) |
| "The protective and adverse effect potentials of levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide) in rodent models of seizures and epilepsy were compared with the profile of several currently prescribed and newly developed antiepileptic drugs." | 7.70 | Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. ( Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E, 1998) |
| "The efficacy of Flunarizine (FLU), a calcium channel blocker, in combination with conventional antiepileptic drugs, phenytoin (PHT), carbamazepine (CBZ), sodium valproate (VPA), and ethosuximide (ESM), at ED50 doses, were examined for protective effects against maximal electroshock seizures (MES) and pentylenetetrazol (PTZ) induced seizures in mice." | 7.70 | Additive anticonvulsant effect of flunarizine and sodium valproate on electroshock and chemoshock induced seizures in mice. ( David, J; Joseph, S; Joseph, T, 1998) |
| "The purpose of this study was to test the hypothesis that a ketogenic diet would increase the resistance of rats to pentylenetetrazole (PTZ)-induced seizures and to understand the relation of ketonemia to seizure resistance." | 7.70 | A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat. ( Bough, KJ; Eagles, DA, 1999) |
| " In order to further evaluate the role of adenosine in seizure activity, we monitored adenosine and its major biochemical metabolites inosine, xanthine, and hypoxanthine in the dorsal hippocampus by in vivo microdialysis before and during the induction of generalized seizures." | 7.70 | Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats. ( Aden, U; Berman, RF; Fredholm, BB; O'Connor, WT, 2000) |
| "Perimenstrual catamenial epilepsy, the exacerbation of seizures in association with menstruation, may in part be due to withdrawal of the progesterone metabolite allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), an endogenous anticonvulsant neurosteroid that is a positive allosteric modulator of gamma-aminobutyric acid(A) receptors." | 7.70 | Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2000) |
| "The effects of muscimol, amino-oxyacetic acid (AOAA), diamino-N-butyric acid (DABA), bicuculline, picrotoxin, diazepam and phenobarbitone on the protective effect of clonidine against pentylenetetrazol-induced seizures were studied in mice." | 7.69 | gamma Aminobutyric acid mediation of the anticonvulsant effect of clonidine on pentylenetetrazol-induced seizures in mice. ( Amabeoku, G; Bwakura, E; Chikuni, O, 1994) |
| "The seizure sensitive Mongolian gerbil, a genetic model of epilepsy, has been used to investigate the effects of prior spontaneous seizures on the threshold for pentylenetetrazole (PTZ) and maximum electroshock (MES) induced convulsions." | 7.67 | The effect of spontaneous seizures on pentylenetetrazole and maximum electroshock induced seizures in the Mongolian gerbil. ( Lee, RJ; Lomax, P, 1984) |
| "Trimethadione was compared with chlordiazepoxide for anti-anxiety activity in two behavioral tests known to predict the anxiolytic action of drugs." | 7.66 | Comparison of the actions of trimethadione and chlordiazepoxide in animal models of anxiety and benzodiazepine receptor binding. ( Bennett, DA; Brugger, S; Dutta, P; Fielding, S; Geyer, H; Lal, H, 1982) |
| "Seizures are a combination of electrical and behavioral events that can induce biochemical, molecular, and anatomic changes." | 6.66 | Experimental Models for the Discovery of Novel Anticonvulsant Drugs: Focus on Pentylenetetrazole-Induced Seizures and Associated Memory Deficits. ( Adem, A; Alachkar, A; Frank, A; Ojha, SK; Sadek, B; Sadeq, A; Stark, H, 2020) |
| "Epilepsy is a prevalent neurological disease, affecting approximately 1-2% of the global population." | 5.91 | Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish. ( Benvenutti, R; Chitolina, R; Herrmann, AP; Linazzi, A; Marcon, M; Piato, A; Reis, CG; Stahlhofer-Buss, T, 2023) |
| "Dravet syndrome is characterized by multiple seizure types: generalized tonic-clonic, focal, myoclonic, and absence seizures." | 5.72 | Stiripentol inhibits spike-and-wave discharges in animal models of absence seizures: A new mechanism of action involving T-type calcium channels. ( Heulard, I; Reversat, L; Riban, V; Si Hocine, H; Verleye, M, 2022) |
| "Epileptic seizures are associated with the overproduction of free radicals in the brain leading to neuronal cell death." | 5.72 | The Effects of Vitamin D3 and Melatonin Combination on Pentylenetetrazole- induced Seizures in Mice. ( Dehdashtian, E; Hosseinzadeh, A; Jafari-Sabet, M; Mehrzadi, S, 2022) |
| "Seizures were induced by pentylenetetrazol and maximal electroshock." | 5.72 | Opioidergic and nitrergic systems mediate the anticonvulsant effect of mefloquine and chloroquine on seizures induced by pentylenetetrazol and maximal electroshock in mice. ( Boroujeni, SS; Dehpour, AR; Jafari, RM; Karimi, E; Maleki, A; Mohammadi, P; Sabzevari, O; Shafaroodi, H; Solaimanian, S, 2022) |
| "Epilepsy is often considered to be a progressive neurological disease, and the nature of this progression remains unclear." | 5.72 | Insights into the development of pentylenetetrazole-induced epileptic seizures from dynamic metabolomic changes. ( Cheng, P; Jia, P; Liao, S; Meng, K; Xiao, C; Xu, R; Zhao, X; Zheng, X, 2022) |
| "The latency, frequency and duration of seizures evaluated using EEG recordings from the frontal and parietal cortices of rats showed significant changes demonstrating the inhibition of paroxystic activity." | 5.62 | Anticonvulsant activity of Valeriana edulis roots and valepotriates on the pentylenetetrazole-induced seizures in rats. ( Contreras-Murillo, G; González-Trujano, ME; Hidalgo-Flores, FJ; López-Najera, CA; Magdaleno-Madrigal, VM; Navarrete-Castro, A; Sánchez, CG, 2021) |
| "In various organisms, stress is a seizure-related comorbidity." | 5.62 | Stress increases susceptibility to pentylenetetrazole-induced seizures in adult zebrafish. ( Canzian, J; Franscescon, F; Müller, TE; Rosa, LV; Rosemberg, DB; Souza, TP; Stefanello, FV, 2021) |
| "Seizures were evaluated by video-EEG during one hour and scored according to Racine scale." | 5.62 | Effect of Memantine on Pentylenetetrazol-induced Seizures and EEG Profile in Animal Model of Cortical Malformation. ( Cagliari Zenki, K; Calcagnotto, ME; Klippel Zanona, Q; Lazzarotto, G, 2021) |
| "The present study aims to evaluate the efficacy of selenium (Se) alone or combined with carbamazepine (CBZ) against the adverse effects induced by the chemoconvulsant pentylenetetrazole (PTZ) in the cortex of adult male rats." | 5.56 | Electrophysiological and Neurochemical Assessment of Selenium Alone or Combined with Carbamazepine in an Animal Model of Epilepsy. ( Aboul Ezz, HS; Ali, MA; Mohammed, HS; Zedan, A, 2020) |
| "In India, it is used for the treatment of epilepsy as traditional medicine." | 5.56 | An interaction study of Ocimum sanctum L. and levetiracetam in pentylenetetrazole kindling model of epilepsy. ( Dinda, AK; Kaleekal, T; Katyal, J; Pattnaik, SS; Sarangi, SC, 2020) |
| "Epilepsy is a debilitating neurological illness that affects all aspect of an individual life." | 5.56 | Prolonged febrile seizure history exacerbates seizure severity in a pentylenetetrazole rat model of epilepsy. ( Alese, OO; Mabandla, MV; Mkhize, NV; Rakgantsho, C; Zulu, S, 2020) |
| "Eclampsia is characterized by high morbidity and mortality wordwide." | 5.51 | Magnesium sulfate attenuates brain edema by lowering AQP4 expression and inhibits glia-mediated neuroinflammation in a rodent model of eclampsia. ( Li, X; Liu, H; Yang, Y, 2019) |
| "The animals were assessed for seizure score, neuronal damage and inflammatory cytokines levels (IL-1β, IL-6 and TNF-α) in hippocampus." | 5.51 | Effect of dimethyl fumarate on neuroinflammation and apoptosis in pentylenetetrazol kindling model in rats. ( Banerjee, D; Bhatia, A; Chakrabarti, A; Kumari, P; Saha, L; Singh, J; Singh, N, 2019) |
| "Epilepsy is a common clinical syndrome characterized by sudden and recurrent attacks and temporary central nervous system dysfunction caused by excessive discharge of neurons in the brain." | 5.51 | Exploratory Cortex Metabolic Profiling Revealed the Sedative Effect of Amber in Pentylenetetrazole-Induced Epilepsy-Like Mice. ( Chen, C; Duan, J; Guo, J; Guo, S; Qian, D; Shang, E; Tang, Z; Yan, H; Zhao, M; Zhu, Y; Zhu, Z, 2019) |
| "However, the latency time to seizure onset was unaltered." | 5.51 | The anticonvulsant and neuroprotective effects of kir2.3 activation in PTZ-induced seizures and the kainic acid model of TLE. ( Hong, Z; Sun, W; Wang, Y; Wu, X; Xu, L; Zhang, L; Zhu, G, 2019) |
| "Epilepsy is a chronic neurological disorder which affects 65 million worldwide population and characterized by recurrent seizure in epileptic patients." | 5.48 | The anti-epileptogenic and cognition enhancing effect of novel 1-[4-(4-benzo [1, 3] dioxol-5-ylmethyl-piperazin-1-yl)-phenyl]-3-phenyl-urea (BPPU) in pentylenetetrazole induced chronic rat model of epilepsy. ( Kumari, S; Mishra, CB; Siraj, F; Tiwari, AK; Tiwari, M; Yadav, R, 2018) |
| "BACKGROUND Epilepsy is a complex neurologic disorder with abnormal electrical impulses in the brain." | 5.48 | Modulation of P2X Purinoceptor 3 (P2X3) in Pentylenetetrazole-Induced Kindling Epilepsy in Rats. ( Han, Z; Wang, H; Xia, J; Zhang, Q, 2018) |
| "Seizures are sustained neuronal hyperexcitability in brain that result in loss of consciousness and injury." | 5.48 | Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish. ( Han, L; He, Q; Ji, X; Jin, M; Liu, K; Sheng, W, 2018) |
| "for 15 days." | 5.46 | Ferulic Acid Supplementation for Management of Depression in Epilepsy. ( Goel, RK; Kaur, T; Singh, T, 2017) |
| "Epilepsy is a common brain disorder characterized by the occurrence of recurring, unprovoked seizures." | 5.46 | EGAR, A Food Protein-Derived Tetrapeptide, Reduces Seizure Activity in Pentylenetetrazole-Induced Epilepsy Models Through α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionate Receptors. ( Cai, M; Cai, S; Chen, L; Duan, S; Gu, H; Lin, R; Ling, C; Lu, J; Pan, X; Wang, Y; Zhu, H, 2017) |
| "Depression was evaluated in all experimental groups using the tail suspension and sucrose preference test on days 1, 5, 10 and 15, 2 h after pentylenetetrazole challenge." | 5.46 | Adjuvant quercetin therapy for combined treatment of epilepsy and comorbid depression. ( Goel, RK; Kaur, T; Singh, T, 2017) |
| "Understanding how the brain responds to seizures is important for development of new treatment strategies for epilepsy, a neurological condition characterized by recurrent and unprovoked seizures." | 5.46 | Cellular responses to recurrent pentylenetetrazole-induced seizures in the adult zebrafish brain. ( Beattie, CE; Berberoglu, MA; Duy, PQ; Hall, CW, 2017) |
| "Taken together, although the seizure threshold is reduced in naive Spry2/4(+/-) mice, neurodegeneration and GCD is mitigated following KA induced hippocampal lesions, identifying Spry proteins as possible pharmacological targets in brain injuries resulting in neurodegeneration." | 5.43 | Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage. ( Agostinho, AS; Burtscher, J; Fogli, B; Hausott, B; Klimaschewski, L; Marvaldi, L; Schwarzer, C; Thongrong, S; Zangrandi, L, 2016) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 5.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "Neonatal or early-life seizures (ELS) are often associated with life-long neurophysiological, cognitive and behavioral deficits, but the underlying mechanisms contributing to these deficits remain poorly understood." | 5.43 | Neonatal seizures induced by pentylenetetrazol or kainic acid disrupt primary cilia growth on developing mouse cortical neurons. ( Atkinson, EW; Coleman, JE; Hoang-Minh, LB; Le, MM; Parker, AK; Sarkisian, MR; Semple-Rowland, S; Smith, TS; Ugartemendia, G, 2016) |
| "Racine convulsion scores, first myoclonic jerk time, spike percentages, and antioxidant status were evaluated in the groups." | 5.43 | Inhibitor effect of paricalcitol in rat model of pentylenetetrazol-induced seizures. ( Çavuşoğlu, T; Çetin, EÖ; Çınar, BP; Erbaş, O; Solmaz, V; Sur, HY; Uyanıkgil, Y, 2016) |
| "Behavioral scoring was used to access seizure." | 5.43 | Anticonvulsant and neuroprotective effects of apelin-13 on pentylenetetrazole-induced seizures in male rats. ( Asadi-Shekaari, M; Esmaeili-Mahani, S; Kalantaripour, TP; Pasban-Aliabadi, H; Sheibani, V, 2016) |
| "Seizures are a known co-occurring symptom of Alzheimer's disease, and they can accelerate cognitive and neuropathological dysfunction." | 5.42 | Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's disease. ( Harrison, FE; Kang, JQ; Kennard, JA; Warner, TA, 2015) |
| "Pentylenetetrazole-induced seizures, in contrast, were not able to change Homer1a mRNA expression." | 5.42 | Maximal electroshock-induced seizures are able to induce Homer1a mRNA expression but not pentylenetetrazole-induced seizures. ( Blanco, MM; Cavarsan, CF; Matsuo, A; Mello, LE, 2015) |
| "Constipation is a common gastrointestinal disorder characterized by symptoms such as straining, hard stool, and infrequent defecation." | 5.42 | Constipation enhances the propensity to seizure in pentylenetetrazole-induced seizure models of mice. ( Inaloo, S; Moezi, L; Pirsalami, F, 2015) |
| "Modafinil, is a wake-promoting drug approved by Food and Drugs Administration (FDA) for narcolepsy and sleep-apnoe syndrome." | 5.42 | Effects of modafinil on pentylenetetrazol-induced convulsive epilepsy. ( Aydin, D; Ekici, F; Ozsoy, S, 2015) |
| "Thalidomide is an old glutamic acid derivative which was initially used as a sedative medication but withdrawn from the market due to the high incidence of teratogenicity." | 5.40 | Nitric oxide mediates the anticonvulsant effects of thalidomide on pentylenetetrazole-induced clonic seizures in mice. ( Ahmadi-Dastgerdi, M; Amanlou, M; Aminizade, M; Bahremand, A; Berijani, S; Dehpour, AR; Dianati, V; Gholizadeh, R; Gooshe, M; Payandemehr, B; Rahimian, R; Sarreshte-Dari, A, 2014) |
| "Here, we hypothesized severe preeclampsia is a state of increased seizure susceptibility due to blood-brain barrier (BBB) disruption and neuroinflammation that lowers seizure threshold." | 5.40 | Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia. ( Chan, SL; Cipolla, MJ; Johnson, AC; LaMarca, B; Moseley, J; Nagle, KJ; Tremble, SM, 2014) |
| "Status epilepticus was induced on the first day of experiment." | 5.39 | Caffeic acid phenethyl ester prevents apoptotic cell death in the developing rat brain after pentylenetetrazole-induced status epilepticus. ( Bayram, E; Karakaya, P; Kurul, SH; Özbal, S; Topçu, Y; Tuğyan, K; Yilmaz, O; Yiş, U, 2013) |
| "Vagus nerve stimulation prevents seizures by continuously activating noradrenergic projections from the brainstem to the cortex." | 5.39 | Closed-loop neural stimulation for pentylenetetrazole-induced seizures in zebrafish. ( Beattie, CE; Hall, CW; Pineda, R, 2013) |
| "In the remaining animals that exhibited seizures, KB-R7943 (3 mg/kg; p." | 5.39 | Probing the role of the sodium/calcium exchanger in pentylenetetrazole-induced generalized seizures in rats. ( N'Gouemo, P, 2013) |
| "EDA has been shown to reduce seizures caused by systemic injection of proconvulsants in an animal model of generalized tonic-clonic seizures." | 5.38 | Effects of ethylenediamine in rodent models of seizure, motor coordination and anxiety. ( Addae, JI; Cruickshank, R; Stone, TW; Walkins, K, 2012) |
| "In this regard, we used a model of clonic seizures induced by pentylenetetrazole (PTZ) in male NMRI mice to investigate whether morphine and citalopram exhibit additive anticonvulsant effects and, if so, whether this effect is mediated through modulation of 5-HT(3) receptors." | 5.37 | The role of 5-HT(3) receptors in the additive anticonvulsant effects of citalopram and morphine on pentylenetetrazole-induced clonic seizures in mice. ( Bahremand, A; Dehpour, AR; Ebrahimi, A; Fakhfouri, G; Ghasemi, A; Ghasemi, M; Loloee, S; Payandemehr, B; Pourmand, N; Rahimian, R; Ziai, P, 2011) |
| "Single seizure and epilepsy is one of the most commonly encountered neurologic disorders in elderly individuals, arising as a result of complex and often multiple acquired underlying pathologies." | 5.35 | Effects of progesterone on total brain tissue adenosine deaminase activity in experimental epilepsy. ( Alptekin, M; Erkutlu, I; Kurtul, N; Pençe, S; Tan, U, 2009) |
| "It has been described that febrile seizures during infancy increase risk of subsequent non-febrile seizures during the adulthood." | 5.35 | Hyperthermic seizures and hyperthermia in immature rats modify the subsequent pentylenetetrazole-induced seizures. ( Gonzalez-Ramirez, M; Orozco-Suarez, SA; Rocha, L; Salgado-Ceballos, H, 2009) |
| "The intensities of seizures induced by pentylenetetrazol or pilocarpine, as well as the percentages of convulsing mice, were significantly reduced in A(2A) receptor knockout (A(2A)R KO) animals." | 5.35 | Adenosine A2A receptor deficient mice are partially resistant to limbic seizures. ( Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM, 2009) |
| " The present study carried out to evaluate the effect of chronic administration of L-arginine (LA) and L-NAME (LN) on pentylenetetrazole (PTZ) induced epilepsy in ovariectomized (OVX) and naïve female rats." | 5.35 | The effect of L-arginine and L-NAME on pentylenetetrazole induced seizures in ovariectomized rats, an in vivo study. ( Alavi, H; Gorji, A; Hosseini, M; Sadeghnia, HR; Salehabadi, S, 2009) |
| "Occurrence of seizures following long-term oral administration of caffeine (0." | 5.35 | Evidence for the involvement of the adenosine A(2A) receptor in the lowered susceptibility to pentylenetetrazol-induced seizures produced in mice by long-term treatment with caffeine. ( Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM, 2008) |
| "infusion of PTZ; (2) suppress the seizures (clonic and tonic) and lethality induced by i." | 5.33 | Anti-epileptogenic effect of beta-carotene and vitamin A in pentylenetetrazole-kindling model of epilepsy in mice. ( Narenjkar, J; Sayyah, M; Yousefi-Pour, M, 2005) |
| "Agmatine pre-treatment significantly reduced the seizure grade and increased the onset time." | 5.33 | Agmatine reduces extracellular glutamate during pentylenetetrazole-induced seizures in rat brain: a potential mechanism for the anticonvulsive effects. ( Feng, Y; LeBlanc, MH; Regunathan, S, 2005) |
| "No spontaneous seizures occurred and no EEG differences were observed between the genotypes in drug naïve mice." | 5.32 | Electroencephalographic characterisation of pentylenetetrazole-induced seizures in mice lacking the alpha 4 subunit of the neuronal nicotinic receptor. ( Berkovic, SF; Drago, J; Finkelstein, DI; Horne, MK; McColl, CD; Wong, JY, 2003) |
| "Seizure activity was observed and seizure patterns and convulsion times were recorded." | 5.32 | Changes in the blood-brain barrier permeability and in the brain tissue trace element concentrations after single and repeated pentylenetetrazole-induced seizures in rats. ( Ates, N; Ilbay, G; Sahin, D, 2003) |
| "In PTZ seizure model Kyo and its analogues exerted strong inhibition on seizure intensity compared with control group." | 5.32 | Effects of kyotorphin and analogues on nociception and pentylenetetrazole seizures. ( Bocheva, AI; Dzambazova-Maximova, EB, 2004) |
| "rats with a pentylenetetrazole-induced seizure score of 3 or more on a seizure scale ranging from 0 to 6) and death rate compared with those obtained for rats pre-treated with an equivalent intraperitoneal dose (140 mg kg-1) of acepifylline ('equivalent dose' referred to here denotes the theophylline content of the two preparations)." | 5.30 | A comparative study of aminophylline- and acepifylline-induced seizures and death in the chemoconvulsion model in rats. ( Chakrabarti, A; Garg, SK; Saini, HK, 1997) |
| "were studied on seizures induced by subcutaneous injection of pentylenetetrazole (PTZ), a widely used antiepileptic screening test believed to model generalized myoclonic seizures." | 5.30 | Antiepileptic effects of NPY on pentylenetetrazole seizures. ( Woldbye, DP, 1998) |
| "tended to decrease seizure intensity and at a dose of 10 mg/kg was ineffective at all." | 5.29 | Further evidence for the interactions between angiotensin II and GABAergic transmission in pentylenetetrazol kindling seizures in mice. ( Georgiev, VP; Kambourova, TS; Lazarova, MB, 1995) |
| "Dexmedetomidine (DEX) is a highly selective alpha 2 agonist with marked sedative and analgesic properties thought to be mediated via reduction of central noradrenergic transmission." | 5.29 | Dexmedetomidine decreases seizure threshold in a rat model of experimental generalized epilepsy. ( McPherson, RW; Mirski, MA; Rossell, LA; Traystman, RJ, 1994) |
| "Midazolam is a water-soluble benzodiazepine proven to be efficacious in sedation, hypnosis, and induction and maintenance of anesthesia." | 5.29 | Intravenous versus intramuscular midazolam in treatment of chemically induced generalized seizures in swine. ( Bradford, SM; Orebaugh, SL, 1994) |
| "However, they do not affect clonic seizures with preserved righting reflexes." | 5.29 | Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis: III. The action of kynurenic acid and glutamic acid diethylester. ( Kusá, R; Mares, P; Roztocilová, L; Velísek, L, 1995) |
| " Though the conventional pentylenetetrazole-induced seizures and electroshock-induced seizures remain the mainstay of any antiepileptic drug screening protocol, considering the diversity of seizure types and underlying pathologies encountered in epilectics, numerous other seizure models have been developed." | 4.80 | METHODS AND CONSIDERATIONS FOR EXPERIMENTAL EVALUATION OF ANTIEPILEPTIC DRUGS. ( George, B; Gupta, YK; Kulkarni, SK; Malhotra, J, 1999) |
| " The present study was conducted to evaluate the effect of probiotic supplementation on pentylenetetrazole (PTZ)-induced seizures in rats." | 4.31 | Electrophysiological, histopathological, and biochemical evaluation of the protective effect of probiotic supplementation against pentylenetetrazole-induced seizures in rats. ( Akin, AT; Aygun, H; Karabulut, D; Kızılaslan, N; Sumbul, O, 2023) |
| "This study aimed to examine the relationship between epilepsy and COX/5-LOX inflammation pathways in the penicillin and pentylenetetrazole (PTZ)-induced epilepsy models." | 4.31 | An involvement of COX and 5-LOX pathways in the penicillin- and pentylenetetrazole (PTZ)-induced epilepsy models. ( Taşdemir, A; Taskiran, M, 2023) |
| "To investigate the effects of different doses of esculetin on epileptiform activity, behavioral seizures, memory impairment, and cortical and hippocampal NF-κB, as a mediator of pro-inflammatory gene induction, and pro-inflammatory cytokines in penicillin- and pentylenetetrazole(PTZ)-induced seizure models in rats." | 4.31 | Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats. ( Ankarali, H; Baranoglu Kilinc, Y; Danis, A; Hanci, F; Kilinc, E; Torun, IE, 2023) |
| " We aimed to evaluate the effect of quercetin on pentylenetetrazole- (PTZ-) induced seizures in male mice focusing on its possible anti-neuroinflammatory and anti-oxidative stress." | 4.31 | Anticonvulsant effect of quercetin in pentylenetetrazole (PTZ)-induced seizures in male mice: The role of anti-neuroinflammatory and anti-oxidative stress. ( Amini-Khoei, H; Korani, MS; Lorigooini, Z; Rahimi-Madiseh, M; Tahmasebi Dehkordi, H; Tavakoli, Z, 2023) |
| " Here, we evaluated its neuroprotective effects at different doses (100 and 200 mg/kg) against pentylenetetrazole (PTZ)-induced seizures." | 4.31 | Neuroprotective effects of Royal Jelly (RJ) against pentylenetetrazole (PTZ)-induced seizures in rats by targeting inflammation and oxidative stress. ( Dolatshahi, M; Hashemi, P; Karimpour, S; Nazarinia, D, 2023) |
| "Pentylenetetrazole (PTZ) was administered to induce seizures in a total number of 48 Sprague-Dawley rats." | 4.31 | N-acetyl cysteine: A new look at its effect on PTZ-induced convulsions. ( Azak Pazarlar, B; Bilister Egilmez, C; Erbas, O; Erdogan, MA, 2023) |
| "A common way to investigate epilepsy and the effect of antiepileptic pharmaceuticals is to analyze the movement patterns of zebrafish larvae treated with different convulsants like pentylenetetrazol (PTZ), pilocarpine, etc." | 4.31 | A comparative study to optimize experimental conditions of pentylenetetrazol and pilocarpine-induced epilepsy in zebrafish larvae. ( Aly, N; Budan, F; Dittrich, B; Gorbe, A; Jin, M; Sik, A; Szentpeteri, JL; Szep, D, 2023) |
| " Here, we conducted present study to evaluate its neuroprotective effects against pentylenetetrazole (PTZ)-induced seizures in rats." | 4.31 | (-)-α-bisabolol exerts neuroprotective effects against pentylenetetrazole-induced seizures in rats by targeting inflammation and oxidative stress. ( Hashemi, P; Moslehi, A; Nazarinia, D, 2023) |
| " In this regard, the effects of oxaprozin (OXP) (a nonsteroidal anti-inflammatory drug) on the experimental model of seizure and memory impairment caused by seizures in rats were investigated in the present study." | 4.12 | Nonsteroidal Anti-inflammatory Drug Oxaprozin is Beneficial Against Seizure-induced Memory Impairment in an Experimental Model of Seizures in Rats: Impact On Oxidative Stress and Nrf2/HO-1 Signaling Pathway. ( Bananej, M; Khatami, P; Khosravi, M; Mirazi, N, 2022) |
| " Ablation of TRPC3 lessens pilocarpine-induced seizures in mice, suggesting that TRPC3 inhibition might represent a novel antiseizure strategy." | 4.12 | Inhibition of TRPC3 channels by a novel pyrazole compound confers antiseizure effects. ( Boda, VK; Hou, R; Jiang, J; Li, L; Li, W; Nagib, MM; Wu, Z; Yasmen, N; Yu, Y; Zhang, S, 2022) |
| "The effect of oxaprozin (OXP) on an experimental model of seizures in rats was investigated in this study." | 4.12 | Anticonvulsant activity of oxaprozin in a rat model of pentylenetetrazole-induced seizure by targeting oxidative stress and SIRT1/PGC1α signaling. ( Bananej, M; Khatami, P; Khosravi, M; Mirazi, N, 2022) |
| "Pentylenetetrazole (PTZ)-induced kindling is an animal model for studying human temporal lobe epilepsy (TLE), which is characterized by alterations of hippocampal neurons and memory." | 4.12 | Protective Effects of Intranasally Administrated Oxytocin-Loaded Nanoparticles on Pentylenetetrazole-Kindling Epilepsy in Terms of Seizure Severity, Memory, Neurogenesis, and Neuronal Damage. ( Emik, S; Sahin, H; Senturk, GE; Yucel, O, 2022) |
| " Here we examine the effects of valproic acid (VA) plus 4-phenylbutyric acid (4-PBA) on abnormal electrical brain activity, ER stress and apoptosis in acute seizures induced by pentylenetetrazole (PTZ)." | 4.12 | 4-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole. ( Amanvermez, R; Arslan, G; Gün, S; Rzayev, E; Tiryaki, ES, 2022) |
| " After 24 h, CCI-injured rats received intraperitoneal injection of pentylenetetrazole 35 mg/kg once every other day until acquisition of generalized seizures." | 4.12 | Activating toll-like receptor 4 after traumatic brain injury inhibits neuroinflammation and the accelerated development of seizures in rats. ( Choopani, S; Pourbadie, HG; Radpour, M; Sayyah, M, 2022) |
| " In this study, we investigated the possible beneficial effects of lasmiditan and sumatriptan against post-stroke seizures in mice and explored underlying mechanisms in their effects." | 4.12 | Neuroprotective effects of Lasmiditan and Sumatriptan in an experimental model of post-stroke seizure in mice: Higher effects with concurrent opioid receptors or K ( Amanlou, A; Dehpour, AR; Ejtemaei-Mehr, S; Eslami, F; Ghasemi, M; Rahimi, N; Rashidian, A; Shayan, M; Solaimanian, S, 2022) |
| " Mice in CSA exhibited electroencephalography (EEG) patterns distinct from kainic acid-induced SE and PTZ alone, clearly differentiating CSA from SE and PTZ-induced myoclonic seizures." | 4.02 | Continuous seizure emergency evoked in mice with pharmacological, electrographic, and pathological features distinct from status epilepticus. ( Barker-Haliski, M; Knox, KM; White, HS; Zierath, DK, 2021) |
| "In spite of use of cannabidiol (CBD), a non-psychoactive cannabinoid, in pediatric patients with epilepsy, preclinical studies on its effects in immature animals are very limited." | 4.02 | Anticonvulsive Effects and Pharmacokinetic Profile of Cannabidiol (CBD) in the Pentylenetetrazol (PTZ) or N-Methyl-D-Aspartate (NMDA) Models of Seizures in Infantile Rats. ( Hložek, T; Kubová, H; Mareš, P; Páleníček, T; Uttl, L, 2021) |
| " In the pharmacodynamic interaction study, seizures were induced using pentylenetetrazole (PTZ) (60 mg/kg, i." | 4.02 | Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats. ( Agarwal, A; Arora, R; Ganeshan N, S; Gupta, YK; Kaleekal, T; Kumar, R; Sarangi, SC, 2021) |
| " The seizures were induced with pentylenetetrazole (PTZ) intraperitoneally at 170 mg/kg, and diazepam (DZP) was used as the control anticonvulsant (2 mg/kg, oral); PA was tested at 10, 50, and 100 mg/kg orally." | 4.02 | Perillyl alcohol decreases the frequency and severity of convulsive-like behavior in the adult zebrafish model of acute seizures. ( Borges, RS; Carvalho, JCT; da Silva Hage-Melim, LI; de Melo, EL; Hu, X; Matias Pereira, AC; Sánchez-Ortíz, BL, 2021) |
| " Some antiseizure drugs (ASDs) have been shown to produce discrepant results in larvae and adults zebrafish, therefore, their anticonvulsant efficacy in subsequent stages of the pentylenetetrazole (PTZ)-induced seizures should be more precisely characterized." | 4.02 | Effects of classic antiseizure drugs on seizure activity and anxiety-like behavior in adult zebrafish. ( Doboszewska, U; Guz, L; Pieróg, M; Poleszak, E; Serefko, A; Socała, K; Szopa, A; Wlaź, P; Wyska, E, 2021) |
| " In the pentylenetetrazole-induced seizure model, 1, 5, or 10 mg/kg vortioxetine demonstrated a significant dose-dependent decrease in mean spike frequency, an increase in the latency to minor and major seizures, and a decrease in total duration of major seizure and convulsion stage." | 4.02 | Vortioxetine increases absence-like seizures in WAG/Rij rats but decreases penicillin- and pentylenetetrazole-induced seizures in Wistar rats. ( Aygun, H; Ayyildiz, M, 2021) |
| " Impact of AdCA on (1) threshold and occurrence of clonic seizures induced by pentylenetetrazole (PTZ) in mice, (2) incidence of tonic seizures induced by maximal electroshock (MES) in mice, and (3) incidence of generalized seizures and duration of evoked afterdischarges in amygdala-kindled rats, were determined." | 4.02 | Anti-Seizure Activity of 1-Adamantane Carboxylic Acid in Common Experimental Seizure Models: Role of Benzodiazepine-GABAA Receptors. ( Gavzan, H; Ghanbari, E; Khoshkroodian, B; Sayyah, M, 2021) |
| " The study looked at how the thiamine supplement impacted pentylenetetrazole (PTZ)-induced seizures in rats and pentylenetetrazole-induced neurotoxicity in the SH-SY5Y cell line." | 4.02 | The modulator action of thiamine against pentylenetetrazole-induced seizures, apoptosis, nitric oxide, and oxidative stress in rats and SH-SY5Y neuronal cell line. ( Ergul, M; Taskiran, AS, 2021) |
| " In the present study, we evaluated data from one of the largest global databases to identify drugs with antiepileptic effects, and subsequently attempted to understand the effect of the combination of antiepileptic drugs and valacyclovir in epileptic seizures using a kindling model." | 4.02 | Examination of the antiepileptic effects of valacyclovir using kindling mice- search for novel antiepileptic agents by drug repositioning using a large medical information database. ( Chuma, M; Goda, M; Horinouchi, Y; Ikeda, Y; Imanishi, M; Ishizawa, K; Izawa-Ishizawa, Y; Jozukuri, N; Niimura, T; Takahashi, S; Takechi, K; Tsuchiya, K; Yanagawa, H; Zamami, Y, 2021) |
| " citratus essential oil (EO) and hydroalcoholic extract (E1) from its leaves, as well as of its related compounds citral (CIT) and geraniol (GER) against the effects of pentylenetetrazole (PTZ) induced seizures in zebrafish (Danio rerio)." | 4.02 | Cymbopogon citratus (DC.) Stapf, citral and geraniol exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures in zebrafish. ( Hacke, ACM; Marques, JA; Miyoshi, E; Pereira, RP, 2021) |
| "A model of acute epilepsy in mice was established using the Pentylenetetrazol (PTZ) ignition method to evaluate the effects of Rhein on the duration and latency of convulsions, and the number and severity of seizures." | 4.02 | Rhein attenuates PTZ‑induced epilepsy and exerts neuroprotective activity via inhibition of the TLR4-NFκB signaling pathway. ( Cao, J; Li, X; Yang, J; Yu, L; Yu, W, 2021) |
| " We investigated effects of long-term probiotics supplementation on epileptic seizures, and inflammatory and oxidant/antioxidant biomarkers in a pentylenetetrazole(PTZ)-induced seizure model in rats." | 4.02 | Protective effects of long-term probiotic mixture supplementation against pentylenetetrazole-induced seizures, inflammation and oxidative stress in rats. ( Ankarali, H; Ankarali, S; Ayhan, D; Cetinkaya, A; Kilinc, E; Torun, IE, 2021) |
| " In pentylenetetrazole-induced acute seizures only BUM532 combined with a sub-effective dose of PB increased the seizure threshold." | 3.96 | Functional characterization of novel bumetanide derivatives for epilepsy treatment. ( Auer, T; Erker, T; Schreppel, P; Schwarzer, C, 2020) |
| "The goal of our study was to examine the long-term effect of vigabatrin (VGB), a γ-aminobutyric acid aminotransferase (GABA-AT) inhibitor on clonazepam (CLO), ethosuximide (ETX) and valproate (VPA) anticonvulsive activity against pentylenetetrazole (PTZ)-induced seizures in mice." | 3.96 | Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration. ( Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ, 2020) |
| " The extracts were evaluated for antiseizure activity using a larval zebrafish epilepsy model with pentylenetetrazole (PTZ)-induced seizures." | 3.96 | Antiseizure potential of the ancient Greek medicinal plant Helleborus odorus subsp. cyclophyllus and identification of its main active principles. ( Brillatz, T; Crawford, AD; Houriet, J; Jacmin, M; Kalpoutzakis, E; Marcourt, L; Pellissier, L; Petrakis, EA; Queiroz, EF; Rutz, A; Skaltsounis, AL; Vougogiannopoulou, K; Wolfender, JL, 2020) |
| " In the earlier work, 2-propanone-1,3,5,5-trimethyl-2-cyclohexen-1-ylidine demonstrated anticonvulsant activity against pentylenetetrazole (PTZ)-induced seizures." | 3.96 | In vivo anticonvulsant activity of 2-propanone-1,3,5,5-trimethyl-2-cyclohexen-1-ylidine in pilocarpine and strychnine induced-seizure models. ( Askani, M; Malhi, SM; Nisar, U; Shaheen, F; Shahid, M; Simjee, SU, 2020) |
| "These findings suggest that the combination of 5-FU and cefepime exacerbates early-onset convulsive seizures and elicits delayed-onset convulsive status epilepticus." | 3.91 | 5-Fluorouracil exacerbates cefepime-induced convulsions in pentylenetetrazol-kindled mice. ( Aso, H; Suemaru, K; Watanabe, M; Yoshikawa, M, 2019) |
| " The chronic model of epilepsy was developed by intraperitoneal injection of pentylenetetrazole (PTZ) at dose of 36." | 3.91 | Fabrication and evaluation of novel quercetin-conjugated Fe ( Ahmadian, SR; Akbari, A; Ghasemi, S; Ghasemi-Kasman, M; Hashemian, M; Moalem-Banhangi, M; Zare, L, 2019) |
| " The agents tested were: alpha-lactoalbumin (ALAC), a whey protein rich in tryptophan, effective in some animal models of epilepsy and on colon/intestine inflammation, valproic acid (VPA), an effective antiepileptic drug in this seizure model, mesalazine (MSZ) an effective aminosalicylate anti-inflammatory treatment against ulcerative colitis and sodium butyrate (NaB), a short chain fatty acid (SCFA) normally produced in the intestine by gut microbiota, important in maintaining gut health and reducing gut inflammation and oxidative stress." | 3.91 | Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy. ( Avagliano, C; Calignano, A; Citraro, R; Constanti, A; De Caro, C; De Sarro, G; di Cesare Mannelli, L; Ghelardini, C; Leo, A; Mainardi, P; Nesci, V; Russo, E; Striano, P, 2019) |
| "We aimed to explore the effects of neuropeptides ghrelin, obestatin, and vasoactive intestinal peptide (VIP) on seizures and plasma concentrations of neuroinflammation biomarkers including calcitonin gene-related peptide (CGRP), substance-P (SP), and interleukin-1 beta (IL-1β) in pentylenetetrazol-induced seizures in rats." | 3.91 | Modulatory effects of neuropeptides on pentylenetetrazol-induced epileptic seizures and neuroinflammation in rats. ( Gunes, H; Kilinc, E, 2019) |
| " This study evaluated the efficacy of sodium valproate encapsulated in nanoparticles in pentylenetetrazole (PTZ) induced acute and kindling models of seizures in male Wistar rats." | 3.91 | Evaluation of sodium valproate loaded nanoparticles in acute and chronic pentylenetetrazole induced seizure models. ( Dinda, AK; Gupta, YK; Kottarath, SK; Meenu, M; Reeta, KH, 2019) |
| " The present study was designed to investigate the effect of acute and chronic administration of thiamine alone and in combination with sub-effective dose of diazepam on pentylenetetrazole (PTZ)-induced tonic-clonic seizures in mice." | 3.91 | Anticonvulsant effects of thiamine on pentylenetetrazole-induced seizure in mice. ( Abed, A; Alinejad, M; Banafshe, HR; Heydari, A; Mesdaghinia, A, 2019) |
| " This study was designed to investigate whether acute treatment with boldine could alter seizures induced by pentylenetetrazole or electroshock in mice." | 3.91 | Acute Boldine Treatment Induces Anti-convulsant Effects in Mice through its Antioxidant Activity. ( Jamshizadeh, A; Moezi, L; Pirsalami, F; Yahosseini, S, 2019) |
| " The present study was designed to evaluate the effect of arbutin supplementation on seizures behavior, memory performance, glial activation, release of inflammatory factors and neuroprotection in pentylenetetrazole-induced kindling model." | 3.91 | Arbutin attenuates cognitive impairment and inflammatory response in pentylenetetrazol-induced kindling model of epilepsy. ( Ahmadian, SR; Ghasemi-Kasman, M; Pouramir, M; Sadeghi, F, 2019) |
| "The effects of edaravone against pentylenetetrazole (PTZ)-induced epilepsy in male albino rats were investigated." | 3.91 | Edaravone acts as a potential therapeutic drug against pentylenetetrazole-induced epilepsy in male albino rats by downregulating cyclooxygenase-II. ( Liu, LM; Lu, Y; Wang, N; Wang, WP, 2019) |
| " Pentylenetetrazole- (PTZ) and pilocarpine-induced seizures are well-established models of human epilepsy." | 3.91 | The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure. ( Jand, A; Mousavi-Hasanzadeh, M; Palizvan, MR; Rezaeian-Varmaziar, H; Shafaat, O, 2019) |
| "The underlying mechanisms for the neuroprotective effects of lithium chloride in neurodegenerative diseases such as seizures remain unknown." | 3.88 | The anticonvulsant activity and cerebral protection of chronic lithium chloride via NMDA receptor/nitric oxide and phospho-ERK. ( Dehpour, AR; Ejtemaei Mehr, S; Esmaeili, J; Ghahremani, MH; Mohammad Jafari, R; Rahimi, N; Rashidian, A; Shadboorestan, A, 2018) |
| " Although it has been reported that AM404, a metabolite of acetaminophen, has anticonvulsant effects in several animal seizure models, little is known about the relation between acetaminophen and seizures." | 3.88 | Anticonvulsant effects of acetaminophen in mice: Comparison with the effects of nonsteroidal anti-inflammatory drugs. ( Araki, H; Aso, H; Suemaru, K; Tanaka, A; Watanabe, M; Yoshikawa, M, 2018) |
| " Here, we investigated whether embryonic exposure to ethanol can increase the susceptibility to pentylenetetrazole (PTZ)-induced seizures in larval zebrafish." | 3.88 | Embryonic exposure to ethanol increases the susceptibility of larval zebrafish to chemically induced seizures. ( Cai, L; Chen, SY; Chen, X; Feng, W; Liu, J; Wang, K; Wu, X; Zou, LP, 2018) |
| " Therefore, hippocampal Pol1 activity was examined in mouse models of epilepsy including kainic acid- and pilocarpine-induced status epilepticus (SE) as well as a single seizure in response to pentylenetetrazole (PTZ)." | 3.88 | RNA Polymerase 1 Is Transiently Regulated by Seizures and Plays a Role in a Pharmacological Kindling Model of Epilepsy. ( Hetman, M; Kolikonda, M; Naik, SP; Parlato, R; Pietrzak, M; Slomnicki, LP; Smith, SC; Vashishta, A, 2018) |
| " The aim of the present study was to explore the effect of a selective CB2 receptor agonist β-caryophyllene (BCP) in models of seizures and cognition in mice." | 3.88 | Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice. ( da Conceição Machado, K; de Carvalho Melo Cavalcante, AA; Gomes Júnior, AL; Momchilova, A; Tchekalarova, J; Tzoneva, R, 2018) |
| " marinoi was extracted by solvents with increasing polarities (hexane, dichloromethane, methanol and water) and these extracts were screened for anticonvulsant activity using a larval zebrafish epilepsy model with seizures induced by the GABAA antagonist pentylenetetrazole." | 3.88 | Zebrafish-based identification of the antiseizure nucleoside inosine from the marine diatom Skeletonema marinoi. ( Brillatz, T; Crawford, AD; Esposito, F; Ianora, A; Jacmin, M; Khamma, S; Lauritano, C; Marcourt, L; Queiroz, EF; Righi, D; Romano, G; Wolfender, JL, 2018) |
| " The aim of this study was to evaluate the effects of corilagin, an ellagitannin extracted from medicinal plants, on the frequency of seizures and cognitive function in a rat model of chronic epilepsy." | 3.88 | Corilagin Reduces the Frequency of Seizures and Improves Cognitive Function in a Rat Model of Chronic Epilepsy. ( Chang, LY; Wei, LL; Yu, H; Yu, X; Zhou, T, 2018) |
| ") to pentylenetetrazole-induced kindling in rats (a model of human epilepsy)." | 3.88 | Pharmacological Evaluation of Novel Flavone from Morus alba in Pentylenetetrazole-Induced Kindling and Oxidative Stress. ( Chinnaboina, GK; Gupta, G; Mishra, A; Singh, M; Veerabhadrappa, KVS; Wang, B, 2018) |
| "The chronic epilepsy model was established by pentylenetetrazole (PTZ) kindling." | 3.88 | Sinomenine exerts anticonvulsant profile and neuroprotective activity in pentylenetetrazole kindled rats: involvement of inhibition of NLRP1 inflammasome. ( Dong, K; Gao, B; Huang, DK; Li, WZ; Wu, WN; Wu, Y; Yang, YJ; Yin, YY; Zhou, J, 2018) |
| " Hence, thalidomide (100, 200 and 400 mg/kg) was herein administered to mice to evaluate possible protection against seizures induced by the systemic administration of neurotoxins: 10 mg/kg of 4-aminopyridine (4-AP), 90 mg/kg of pentylenetetrazol (PTZ), or 380 mg/kg of pilocarpine." | 3.88 | Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice. ( Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER, 2018) |
| " All rats except those from the sham group were treated with PTZ to establish temporal lobe epilepsy (TLE) models, whereas the P38 MAPK inhibitor SB 203580 was given to the inhibitor group." | 3.85 | P38 MAPK pathway mediates cognitive damage in pentylenetetrazole-induced epilepsy via apoptosis cascade. ( Huang, Q; Huang, Y; Liao, Y; Liu, X; Ma, M; Wei, X; Wu, Y, 2017) |
| " In contrast, impaired performance in the Morris water maze test and decreased anxiety-like behavior persisted together with an increased susceptibility to pentylenetetrazole-induced seizures suggesting alterations in neural activity patterns." | 3.85 | Traumatic brain injury causes long-term behavioral changes related to region-specific increases of cerebral blood flow. ( Angenstein, F; Goldschmidt, J; Hummel, R; Pöttker, B; Radyushkin, K; Schäfer, MKE; Stöber, F, 2017) |
| "We induced generalized tonic-clonic seizures with the administration of 60 mg/kg pentylenetetrazole (PTZ) in male Wistar Albino rats." | 3.85 | The Effects of Adenosinergic Modulation on Cytokine Levels in a Pentylenetetrazole-Induced Generalized Tonic-Clonic Seizure Model. ( Ateş, N; Dede, F; Eraldemir, FC; Karadenizli, S; Özsoy, ÖD; Şahin, D, 2017) |
| " 24h later, animals were subjected to seizures by using either maximal electro shock or pentylenetetrazole." | 3.85 | Increase in seizure susceptibility in sepsis like condition explained by spiking cytokines and altered adhesion molecules level with impaired blood brain barrier integrity in experimental model of rats treated with lipopolysaccharides. ( Chakrabarti, A; Medhi, B; Modi, M; Saikia, UN; Sewal, RK, 2017) |
| " This study aimed to examine the relationship of ADO with the mammalian target of rapamycin (mTOR) in a Wistar rat model of pentylenetetrazole (PTZ)-induced acute status epilepticus." | 3.85 | Attenuation of pentylenetrazole-induced acute status epilepticus in rats by adenosine involves inhibition of the mammalian target of rapamycin pathway. ( Chen, J; Han, T; Liu, X; Su, L; Wang, Y; Zang, K, 2017) |
| " The role of MAC in oxidative stress and inflammation after pentylenetetrazole (PTZ)-induced kindling was investigated by measuring reactive oxygen species (ROS) production, superoxide dismutase (SOD), and catalase (CAT) activities, nitrite content, and deoxyribonucleic acid (DNA) damage in cerebral cortex." | 3.85 | Manual acupuncture improves parameters associated with oxidative stress and inflammation in PTZ-induced kindling in mice. ( Coelho, VR; da Silva, JB; da Silva, LL; de Souza, MS; Frantz, AL; Pereira, P; Pflüger, P; Picada, JN; Regner, GG; Saffi, J; Viau, CM, 2017) |
| " Does GHRH enhance the inhibitory effect of GABA to prevent epilepsy by increasing the GABA level and activating GABARs? In this study, patients with epilepsy and C57/BL6 mice with epilepsy induced by kainic acid (KA) or pentylenetetrazol (PTZ) served as the research subjects." | 3.85 | Interactions between GHRH and GABAARs in the brains of patients with epilepsy and in animal models of epilepsy. ( Huang, H; Lu, X; Luo, Z; Qiu, X; Tang, S; Xu, Z; Zhang, Y, 2017) |
| " Ferulic acid is a phenolic phytochemical with antioxidant and neuroprotective properties that prompted us to evaluate its therapeutic potential in epilepsy which is usually associated with oxidative stress and cognitive decline." | 3.85 | Ferulic acid exhibits antiepileptogenic effect and prevents oxidative stress and cognitive impairment in the kindling model of epilepsy. ( Arbabi, E; Atyabi, F; Dinarvand, R; Hassanzadeh, P, 2017) |
| " Anticonvulsant activity was tested against clonic seizures induced by pentylenetetrazole (PTZ, 60 mg/kg, i." | 3.85 | In silico Screening and Evaluation of the Anticonvulsant Activity of Docosahexaenoic Acid-Like Molecules in Experimental Models of Seizures. ( Gharibi Loron, A; Narenjkar, J; Sardari, S; Sayyah, M, 2017) |
| "In this study, the effects of levosimendan on seizure susceptibility was studied by PTZ-induced seizures model in mice." | 3.85 | Levosimendan exerts anticonvulsant properties against PTZ-induced seizures in mice through activation of nNOS/NO pathway: Role for K ( Aleyasin, AR; Amini-Khoei, H; Amiri, S; Dehpour, AR; Ghasemi, K; Gooshe, M; Mojahedi, P; Tabaeizadeh, M; Vafaei, A; Yousefi, F, 2017) |
| " Here, we found that gastrodin ameliorated pentylenetetrazole (PTZ)-induced epileptic seizures with improvement of the electroencephalographic pattern in mice." | 3.85 | Gastrodin Attenuates Pentylenetetrazole-Induced Seizures by Modulating the Mitogen-Activated Protein Kinase-Associated Inflammatory Responses in Mice. ( Chen, L; Liu, X; Qu, M; Wang, H, 2017) |
| " We investigated the effects of oleuropein on pentylenetetrazole (PTZ)-induced seizures in male NMRI mice, with diazepam as the standard drug." | 3.85 | Effects of oleuropein on pentylenetetrazol-induced seizures in mice: involvement of opioidergic and nitrergic systems. ( Dehpour, AR; Delfan, B; Motamed-Gorji, N; Rahimi, N, 2017) |
| " Based on previous results in rodents, we have here examined the effects of artificial sweetener sodium cyclamate and antimicrobial agent sodium propylparaben on a model of pentylenetetrazole (PTZ)-induced seizures in zebrafish." | 3.85 | Anticonvulsant effect of sodium cyclamate and propylparaben on pentylenetetrazol-induced seizures in zebrafish. ( Bernabeu, R; Bruno-Blanch, L; Otero, S; Pisera-Fuster, A; Talevi, A, 2017) |
| " The rats were decapitated at the 24th or 72nd hour of seizures and brain tissues were obtained for histopathological examination and for measuring levels of malondialdehyde (MDA), glutathione (GSH), reactive oxygen radicals and myeloperoxidase (MPO) activity." | 3.85 | Obestatin improves oxidative brain damage and memory dysfunction in rats induced with an epileptic seizure. ( Akakın, D; Atal, SS; Kervancıoğlu Demirci, E; Koyuncuoğlu, T; Üren, D; Vızdıklar, C; Yeğen, BÇ; Yıldırım, Ç; Yılmaz, H; Yüksel, M, 2017) |
| " Seizures were induced with one of Pentelyntetrazole (PTZ), 4-Aminopyridine (AP) and Strychnine (STR)." | 3.85 | Antiseizure Effects of Ketogenic Diet on Seizures Induced with Pentylenetetrazole, 4-Aminopyridine and Strychnine in Wistar Rats. ( Desalu, OO; Kolo, PM; Olarinoye, JK; Olatunji, LA; Sanya, EO; Soladoye, AO, 2017) |
| " The present study was designed to investigate synergistic anticonvulsant effects of pregabalin with amlodipine on acute seizure model of epilepsy in mice." | 3.85 | Synergistic anticonvulsant effects of pregabalin and amlodipine on acute seizure model of epilepsy in mice. ( Khan, RA; Qureshi, IH; Riaz, A; Siddiqui, AA, 2017) |
| " The initial anticonvulsant screening was performed in mice (ip) using the 'classical' maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) tests as well as in the six-Hertz (6Hz) model of pharmacoresistant limbic seizures." | 3.83 | New hybrid molecules with anticonvulsant and antinociceptive activity derived from 3-methyl- or 3,3-dimethyl-1-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]pyrrolidine-2,5-diones. ( Abram, M; Andres-Mach, M; Kamiński, K; Obniska, J; Rapacz, A; Zagaja, M; Łuszczki, JJ, 2016) |
| " In addition to anxiety and depressive-like behaviors, we previously showed that juvenile SIS increases susceptibility to pentylenetetrazole (PTZ)-induced seizures in mice through enhancing the nitrergic system activity in the hippocampus." | 3.83 | NMDA receptor antagonists attenuate the proconvulsant effect of juvenile social isolation in male mice. ( Amini-khoei, H; Amiri, S; Azizi, R; Dehpour, AR; Ghazi-Khansari, M; Haj-Mirzaian, A; Mehr, SE; Momeny, M; Rahimi-Balaei, M; Shirzadian, A; Zarrinrad, G, 2016) |
| " This study was conducted to investigate whether or not triamterene, a K(+)-sparing diuretic, can generate protection against seizures induced by intravenous or intraperitoneal pentylenetetrazole (PTZ) models." | 3.83 | A role for ATP-sensitive potassium channels in the anticonvulsant effects of triamterene in mice. ( Almasirad, A; Barati, S; Ghasemi, M; Moezi, L; Shafaroodi, H, 2016) |
| "It has been demonstrated that the zebrafish model of pentylenetetrazole (PTZ)-evoked seizures and the well-established rodent models of epilepsy are similar pertaining to behavior, electrographic features, and c-fos expression." | 3.83 | Indomethacin treatment prior to pentylenetetrazole-induced seizures downregulates the expression of il1b and cox2 and decreases seizure-like behavior in zebrafish larvae. ( Barbalho, PG; Lopes-Cendes, I; Maurer-Morelli, CV, 2016) |
| "Pentylenetetrazole (PTZ), γ-aminobutyrate (GABA) antagonist, is a convulsant drug, known to induce anxiety and seizures in zebrafish." | 3.83 | Anxiety-related behavioral responses of pentylenetetrazole-treated zebrafish larvae to light-dark transitions. ( Guo, N; Ji, Y; Li, Q; Lin, J; Liu, X; Peng, X; Yang, X; Zhang, Y; Zhu, Y, 2016) |
| "Our findings indicate that the administration of nicotine may attenuate microglial activity and increase eclampsia-like seizure threshold in rat hippocampus through the α7 nicotinic receptor." | 3.83 | Nicotine increases eclampsia-like seizure threshold and attenuates microglial activity in rat hippocampus through the α7 nicotinic acetylcholine receptor. ( Bao, J; Han, X; Li, X; Liu, H; Liu, Y; Thakur, M; Ye, A, 2016) |
| " In this study we assessed the susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice with genetically altered uric acid levels by targeting urate oxidase, which is the enzyme responsible for uric acid breakdown." | 3.83 | Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice. ( Boon, P; Carrette, E; Delbeke, J; Glorieux, G; Larsen, LE; Portelli, J; Raedt, R; Sprengers, M; Thyrion, L; Van Lysebettens, W; Vonck, K, 2016) |
| " Changes in breathing and cardiac electrical activity in DBA/1 and C57BL/6J mice that incurred sudden death during generalized seizures evoked by pentylenetetrazole (PTZ) were studied by plethysmography and electrocardiography." | 3.83 | 5-Hydroxytryptophan, a precursor for serotonin synthesis, reduces seizure-induced respiratory arrest. ( Cotten, JF; Feng, HJ; Xue, Q; Yang, X; Zhang, H; Zhao, H, 2016) |
| "The new N-Mannich bases were effective in maximal electroshock or pentylenetetrazole seizures screens; and the most interesting compound 4 (1-{[4-(1-phenyethyl)-piperazin-1-yl]methyl}-3',4'-dihydro-1'H,2H,5H-spiro[imidazolidine-4,2'-naphthalene]-2,5-dione) displayed anticonvulsant activity in both the aforementioned tests." | 3.83 | Design, synthesis, anticonvulsant, and antiarrhythmic properties of novel N-Mannich base and amide derivatives of β-tetralinohydantoin. ( Bednarski, M; Byrtus, H; Czopek, A; Kazek, G; Pawłowski, M; Sapa, J; Siwek, A; Zagórska, A, 2016) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 3.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| "The present study aimed to develop a neurochemistry-based single or adjuvant therapy approach for comprehensive management of epilepsy and associated depression employing pentylenetetrazole-kindled animals." | 3.83 | Evidence in support of using a neurochemistry approach to identify therapy for both epilepsy and associated depression. ( Goel, RK; Singh, T, 2016) |
| " This study investigates the effect of Arginine-Vasopressin (AVP) in pentylenetetrazol (PTZ)-induced seizures threshold and the probable role of nitric oxide (NO)." | 3.83 | The modulatory effect of nitric oxide in pro- and anti-convulsive effects of vasopressin in PTZ-induced seizures threshold in mice. ( Dehpour, AR; Doustimotlagh, AH; Javadi-Paydar, M; Javadian, N; Rahimi, N, 2016) |
| "Hence, this study was conducted to evaluate the effects of an active fraction extracted from the leaves of Crinum jagus against seizures, depression-like behaviour and oxidative stress in pentylenetetrazole (PTZ)-induced kindling in mice." | 3.83 | Anticonvulsant activity of an active fraction extracted from Crinum jagus L. (Amaryllidaceae), and its possible effects on fully kindled seizures, depression-like behaviour and oxidative stress in experimental rodent models. ( Dabole, B; De Waard, M; Menanga, JR; Taiwe, GS; Tchoya, TB, 2016) |
| "The present experiments were performed in ten pigs where IT seizures were induced by controlled infusion of pentylenetetrazole." | 3.83 | Changes in vagus nerve activity associated with ictal tachycardia in pigs. ( Nielsen, TN; Sevcencu, C; Struijk, JJ, 2016) |
| " Although efficacious, AMPA-receptor antagonists, including perampanel (Fycompa), the only approved antagonist for epilepsy, induce dizziness and motor impairment." | 3.83 | Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism. ( Bredt, DS; Burris, KD; Catlow, JT; Ding, C; Fitch, TE; Fitzjohn, SM; Gardinier, KM; Gernert, DL; Gleason, SD; Heinz, BA; Isaac, JT; Kato, AS; Lee, MR; Nisenbaum, ES; Ornstein, PL; Pasqui, F; Porter, WJ; Qian, Y; Rasmussen, K; Reel, J; Schober, DA; Sher, E; Tu, Y; Wafford, KA; Wang, H; Witkin, JM; Yu, H; Zwart, R, 2016) |
| " We aim to reveal the anticonvulsant effects of dexketoprofen in pentylenetetrazol (PTZ)-induced seizures in rats." | 3.81 | Inhibitor effect of dexketoprofen in rat model of pentylenetetrazol-induced seizures. ( Aksoy, D; Erbaş, O; Solmaz, V, 2015) |
| " Intraperitoneal pentylenetetrazole injection did not induce any seizure activity in the control rats, although it elicited seizures of variable severity in the polymicrogyria rats." | 3.81 | Increased expression of GAP43 in interneurons in a rat model of experimental polymicrogyria. ( Matsui, K; Takano, T, 2015) |
| "Influence of ozone's treatments in mice submitted to PTZ-induced seizures was studied." | 3.81 | Ozone protective effects against PTZ-induced generalized seizures are mediated by reestablishment of cellular redox balance and A1 adenosine receptors. ( Cedeño, RI; Fernández, OS; Mallok, A; Pérez, AF; Soto, MT; Vaillant, JD; Viart, Mde L; Viebahn-Hänsler, R, 2015) |
| "All the control rats presented generalized tonic-clonic seizures after the administration of pentylenetetrazole." | 3.81 | Anticonvulsant effects of mefloquine on generalized tonic-clonic seizures induced by two acute models in rats. ( Ballesteros-Zebadúa, P; Franco-Pérez, J; Manjarrez-Marmolejo, J, 2015) |
| " The present study investigated the effect of the PPAR-γ agonist, pioglitazone, on the mammalian target of rapamycin (mTOR) signaling pathway in a rat model of pentylenetetrazol (PTZ)-induced status epilepticus (SE)." | 3.81 | Peroxisome proliferator-activated receptor-γ agonist inhibits the mammalian target of rapamycin signaling pathway and has a protective effect in a rat model of status epilepticus. ( Liu, Y; San, YZ; Shi, PP; Zhang, Y; Zhu, YL, 2015) |
| " In this study, we investigated the expression of JIP3 in temporal lobe epilepsy (TLE) and in a kainic acid (KA)-induced mouse model of epileptic seizures, and determined whether down-regulation of JIP3 can decrease susceptibility to seizures and neuron damage induced by KA." | 3.81 | Effects of JIP3 on epileptic seizures: Evidence from temporal lobe epilepsy patients, kainic-induced acute seizures and pentylenetetrazole-induced kindled seizures. ( Chen, X; Chen, Y; Cheng, L; Deng, W; Li, J; Li, Y; Lü, Y; Mi, X; Wang, N; Wang, X; Wang, Z; Xu, X; Zhang, Y, 2015) |
| " We evaluated influence of DHA on anticonvulsant activity of AEDs phenytoin, valproate, and lamotrigine in maximal electroshock (MES), pentylenetetrazole (PTZ), and kindling models of epilepsy." | 3.81 | Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models. ( Babapour, V; Gavzan, H; Sardari, S; Sayyah, M, 2015) |
| " In our study, we investigated the effects of rapamycin pretreatment on pentylenetetrazole (PTZ)-induced seizures in zebrafish." | 3.81 | Rapamycin suppresses PTZ-induced seizures at different developmental stages of zebrafish. ( Bonan, CD; da Costa Schaefer, I; Menezes, FP; Petersen, BD; Siebel, AM, 2015) |
| " Thirty mice that developed seizures were randomly divided into three groups and administered PHT as well as the following treatments: saline (negative control); verapamil (20 mg/kg, positive control); and G." | 3.81 | Reversal of P-glycoprotein overexpression by Ginkgo biloba extract in the brains of pentylenetetrazole-kindled and phenytoin-treated mice. ( Chen, SL; Fan, Q; Ma, H; Zhang, C, 2015) |
| " Epileptic rats that developed spontaneous recurrent seizures after a pilocarpine-induced status epilepticus were treated with a KD or control diet (CD)." | 3.81 | Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats. ( Akula, KK; Boison, D; Coffman, SQ; Lusardi, TA; Masino, SA; Ruskin, DN, 2015) |
| "Epilepsy is a neurological disorder that has been associated with oxidative stress therefore epilepsy models have been develop such as kainic acid and pentylenetetrazol are usually used to understanding of the molecular mechanisms of this disease." | 3.81 | Metallothionein expression in the rat brain following KA and PTZ treatment. ( Díaz-Ruíz, A; Flores-Espinosa, P; Heras-Romero, Y; Juárez-Rebollar, D; Manjarrez, J; Méndez-Armenta, M; Nava-Ruíz, C; Zaga-Clavellina, V, 2015) |
| "The effects of coadministration of melatonin and theanine (Mel/Thea) on pentylenetetrazole (PTZ)-induced seizures and brain tissue oxidative damage were investigated in ovariectomized (OVX) and sham-operated rats." | 3.81 | Effects of melatonin and theanine administration on pentylenetetrazole-induced seizures and brain tissue oxidative damage in ovariectomized rats. ( Choopankareh, S; Hosseini, M; Sadeghnia, HR; Salarinia, R; Shafei, MN; Vafaee, F; Zarepoor, L, 2015) |
| " Secondly, we determined seizure threshold for H1 and H3 receptors agonists and antagonists in mouse model of pentylenetetrazole (PTZ)-induced clonic seizures." | 3.81 | Morphine modulates the effects of histamine H1 and H3 receptors on seizure susceptibility in pentylenetetrazole-induced seizure model of mice. ( Alijanpour, S; Amini-Khoei, H; Amiri, S; Dehpour, AR; Gooshe, M; Haj-Mirzaian, A; Hassanipour, M; Mehr, SE; Rahimi-Balaei, M; Shirzadian, A, 2015) |
| " The present study evaluated the anticonvulsant effect of ginger in a model of clonic seizures induced with pentylenetetrazole (PTZ) in male mice." | 3.80 | Acute administration of ginger (Zingiber officinale rhizomes) extract on timed intravenous pentylenetetrazol infusion seizure model in mice. ( Hosseini, A; Mirazi, N, 2014) |
| "There is considerable interest in using bumetanide, a chloride importer Na-K-Cl cotransporter antagonist, for treatment of neurological diseases, such as epilepsy or ischemic and traumatic brain injury, that may involve deranged cellular chloride homeostasis." | 3.80 | A novel prodrug-based strategy to increase effects of bumetanide in epilepsy. ( Brandt, C; Brunhofer, G; Erker, T; Feit, PW; Gabriel, M; Kaila, K; Lindfors, J; Löscher, W; Töllner, K; Töpfer, M, 2014) |
| "To explore the role of innate immunity in the mechanism of epilepsy, the pentylenetetrazole (PTZ) kindling rat model was established using intraperitoneal injection of PTZ." | 3.80 | Expression of SOCSs and TLRs in the hippocampus of pentylenetetrazole kindling model. ( Dang, J; Ding, DX; Huang, WJ; Liu, H; Song, MY; Tian, FF; Wang, YZ, 2014) |
| "The aims of this study were to characterize a lamotrigine-resistant kindled model of epilepsy in mice, to study the anticonvulsant effect of carbamazepine (CBZ) and valproic acid (VPA), and to probe into the mechanism for resistance." | 3.80 | Characterization of a lamotrigine-resistant kindled model of epilepsy in mice: evaluation of drug resistance mechanisms. ( Mehndiratta, M; Pillai, KK; Singh, E, 2014) |
| "Novel N3 aryl/heteroaryl substituted 2-((benzyloxy and phenylthio) methyl) 6,7-dimethoxyquinazolin-4(3H)- ones (8a-8l) were synthesized and evaluated for their anticonvulsant activity using various models of epilepsy, such as maximal electroshock (MES), subcutaneous pentylenetetrazole (scPTZ) and intracerebroventricular AMPA (α-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid)-induced seizures in mice." | 3.80 | Design, synthesis and pharmacological evaluation of N3 aryl/ heteroaryl substituted 2-((benzyloxy and phenylthio) methyl) 6,7- dimethoxyquinazolin-4(3H)-ones as potential anticonvulsant agents. ( Banerjee, AG; Das, N; Shrivastava, SK, 2014) |
| " This study was designed to investigate whether acute or subchronic treatment with coenzyme Q10 altered the seizures induced by pentylenetetrazole or electroshock in mice." | 3.80 | The effects of coenzyme Q10 on seizures in mice: the involvement of nitric oxide. ( Moezi, L; Mousavi, Z; Sattarinezhad, E; Shafaroodi, H; Sheikhnouri, K, 2014) |
| " Pentylenetetrazole (PTZ)-kindled and spontaneous model of epilepsy (EL) mice were used as models of chemically induced and spontaneous epilepsy, respectively." | 3.80 | Pharmacoproteomics-based reconstruction of in vivo P-glycoprotein function at blood-brain barrier and brain distribution of substrate verapamil in pentylenetetrazole-kindled epilepsy, spontaneous epilepsy, and phenytoin treatment models. ( Ohtsuki, S; Terasaki, T; Uchida, Y, 2014) |
| " Susceptibility to pentylenetetrazole-induced seizures was assessed by electrocorticography in head-restrained nonanesthetized rats." | 3.80 | Normotopic cortex is the major contributor to epilepsy in experimental double cortex. ( Buhler, E; Chauvin, Y; Jalabert, M; Malvache, A; Manent, JB; Peret, A; Petit, LF; Represa, A; Watrin, F, 2014) |
| "The present study was aimed to investigate the potential beneficial effect of curcumin, a polyphenol with pleiotropic properties, on mitochondrial dysfunctions, oxidative stress and cognitive deficits in a kindled model of epilepsy." | 3.80 | Curcumin supplementation improves mitochondrial and behavioral deficits in experimental model of chronic epilepsy. ( Bal, A; Kaur, H; Sandhir, R, 2014) |
| "These data indicate that MSCs were superior to gabapentin in ameliorating PTZ-induced epileptogenesis and verified the potential use of MSCs in seizure control, motor and cognitive impairments, oxidative stress, and the impairing GABA level in experimentally induced epilepsy." | 3.80 | Effects of intravenous human umbilical cord blood mesenchymal stem cell therapy versus gabapentin in pentylenetetrazole-induced chronic epilepsy in rats. ( Essawy, SS; Ewais, MM; Mohammed, AS; Tawfik, MK, 2014) |
| "Besides the clinical applications of penicillamine, some reports show that use of D-penicillamine (D-pen) has been associated with adverse effects such as seizures." | 3.80 | Effects of D-penicillamine on pentylenetetrazole-induced seizures in mice: involvement of nitric oxide/NMDA pathways. ( Dehpour, AR; Heidary, MR; Javadi-Paydar, M; Jazaeri, F; Rahimi, N; Sadeghzadeh, M, 2014) |
| "We have previously reported that an episode of pentylenetetrazole (PTZ)-induced status epilepticus (SE) in immature rats induces a long-term increase in cholinergic excitation assessed in the adult brain in vitro." | 3.80 | A single episode of juvenile status epilepticus reduces the threshold to adult seizures in a stimulus-specific way. ( Kouis, P; Mikroulis, A; Psarropoulou, C, 2014) |
| "It was the aim of this study to determine the potential effect of walnut kernel extract (WKE) on experimentally induced seizures in rats and to evaluate the role of benzodiazepines and ethosuximide (ESM) within these pathways." | 3.80 | Potential mechanisms involved in the anticonvulsant effect of walnut extract on pentylenetetrazole-induced seizure. ( Asadi-Shekaari, M; Eslami, A; Joukar, S; Kalantaripour, T, 2014) |
| " To do this, we used the pentylenetetrazole (PTZ) model of clonic seizures, open-field test, hole-board test, forced swimming test, and plasma corticosterone assay." | 3.80 | Involvement of the nitrergic system in the proconvulsant effect of social isolation stress in male mice. ( Amiri, S; Dehpour, AR; Haj-Mirzaian, A; Imran-Khan, M; Kordjazy, N; Mehr, SE; Rahimi Balaei, M; Shirzadian, A, 2014) |
| "Alterations in the NO pathway play an important role in the development of convulsive seizures via the glutamatergic and GABAergic systems in acute pentylenetetrazole (PTZ) seizure animals." | 3.79 | The threshold of pentylenetetrazole-induced convulsive seizures, but not that of nonconvulsive seizures, is controlled by the nitric oxide levels in murine brains. ( Danjo, S; Itoh, K; Miyai, A; Nakamura, Y; Watanabe, M, 2013) |
| "Pentylenetetrazole (PTZ) is a widely-used convulsant used in studies of epilepsy; its subcutaneous injection generates an animal model with stable seizures." | 3.79 | BDNF-TrkB signaling pathway is involved in pentylenetetrazole-evoked progression of epileptiform activity in hippocampal neurons in anesthetized rats. ( Ding, J; Fan, W; Jin, LY; Liu, J; Liu, X; Liu, XL; Peng, LC; Wang, X; Wang, Y, 2013) |
| "Adenosine agonists or low doses of morphine exert anti-convulsant effects in different models of seizures." | 3.79 | The interaction of adenosine and morphine on pentylenetetrazole-induced seizure threshold in mice. ( Akbarian, R; Moezi, L; Niknahad, H; Shafaroodi, H, 2013) |
| " perforatum was compared with standard antidepressants using animal models of depression such as forced swim test (FST), yohimbine induced lethality test, pnetylenetetrazole (PTZ) induced convulsion and locomotor activity tests." | 3.79 | Behavioral profile of Hypericum perforatum (St. John's Wort) extract. A comparison with standard antidepressants in animal models of depression. ( Bukhari, IA; Dar, A, 2013) |
| "The anticonvulsant effect of dicholine succinate (DCS), a neuronal insulin sensitizer, has been studied on two models of primary generalized epilepsy induced by corazole and maximal electroshock (ME) in mice." | 3.79 | [Anticonvulsant effect of dicholine succinate on primary generalized epilepsy model in mice]. ( Pomytkin, IA; Rychikhin, VM; Sariev, AK, 2013) |
| " Initial anticonvulsant screening was performed in mice (ip) using the maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) seizures tests." | 3.79 | Design, synthesis and anticonvulsant properties of new N-Mannich bases derived from 3-phenylpyrrolidine-2,5-diones. ( Chlebek, I; Kamiński, K; Obniska, J; Rzepka, S; Wiklik, B, 2013) |
| " (MQ) in maximal electroshock (MES) and pentylenetetrazole (PTZ) induced rat models of epilepsy." | 3.79 | Evaluation of anti-epileptic property of Marsilea quadrifolia Linn. in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy. ( Avinash, H; Chandrashekar, BR; Mukunda, N; Naduvil Narayanan, S; Nayak, BS; Raghavendra Rao, K; Sadhana, N; Satish Kumar, MC; Snehunsu, A; Vijay Kapgal, K, 2013) |
| " This new method documented that seizures in the zebrafish EAST model were ameliorated by pentobarbitone, but not diazepam, validating its usefulness." | 3.79 | Epilepsy in kcnj10 morphant zebrafish assessed with a novel method for long-term EEG recordings. ( Bockenhauer, D; Kleta, R; Mahmood, F; Russell, C; Stanescu, HC; Zdebik, AA, 2013) |
| "In a previous study, we uncovered the anticonvulsant properties of turmeric oil and its sesquiterpenoids (ar-turmerone, α-, β-turmerone and α-atlantone) in both zebrafish and mouse models of chemically-induced seizures using pentylenetetrazole (PTZ)." | 3.79 | Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy. ( Afrikanova, T; Aibuldinov, YK; de Witte, PA; Dehaen, W; Esguerra, CV; Orellana-Paucar, AM; Thomas, J, 2013) |
| " Thus, this study was carried out to evaluate the acute effect of liposome-entrapped curcumin on increasing current electroshock seizures (ICES) test, pentylenetetrazole (PTZ)-induced seizures, and status epilepticus in mice." | 3.79 | Liposomal formulation of curcumin attenuates seizures in different experimental models of epilepsy in mice. ( Agarwal, NB; Agarwal, NK; Jain, S; Mediratta, PK; Nagpal, D; Sharma, KK, 2013) |
| "We aimed to reveal the anti-convulsant effects of oxytocin (OT) in pentylenetetrazol (PTZ)-induced seizures in rats." | 3.79 | Oxytocin inhibits pentylentetrazol-induced seizures in the rat. ( Bora, S; Erbas, O; Evren, V; Korkmaz, HA; Peker, G; Yılmaz, M, 2013) |
| " Our data have demonstrated that pentylenetetrazole (PTZ)-induced seizures did not alter ATP, ADP, and AMP hydrolysis in brain membrane fractions." | 3.79 | Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish. ( Bogo, MR; Bonan, CD; Nery, LR; Piato, AL; Schaefer, IC; Siebel, AM, 2013) |
| " We here investigated for the first time the effect of L-theanine intake on seizure susceptibility using acute pilocarpine and pentylenetetrazol (PTZ) mouse models for studying, respectively, limbic seizures or primarily generalized seizures." | 3.79 | L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures. ( Loyens, E; Massie, A; Michotte, Y; Schallier, A; Smolders, I; Van Liefferinge, J; Vermoesen, K, 2013) |
| "To investigate the anticonvulsant activity of the lobeline isolated from the Lobelia nicotianaefolia in chemoconvulsant-induced seizures and its biochemical mechanism by investigating relationship between seizure activities and altered gamma amino butyric acid (GABA) in brain of mice in Pentylenetetrazol (PTZ) seizure models." | 3.78 | Antiepileptic activity of lobeline isolated from the leaf of Lobelia nicotianaefolia and its effect on brain GABA level in mice. ( Bodhankar, SL; Ghosh, P; Rub, RA; Tamboli, AM, 2012) |
| " In vitro, sodium selenate reduced tau phosphorylation in human neuroblastoma cells and reversed the increase in tau phosphorylation induced by the PP2A inhibitor, okadaic acid." | 3.78 | Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models. ( Chen, T; Corcoran, NM; Grundy, R; Hovens, CM; Jones, NC; Nguyen, T; O'Brien, TJ; Velakoulis, D, 2012) |
| "The possible involvement of oxytocin (OT) in the generation of seizures has not received a lot of attention in the past, although generalized epileptic convulsions were observed in humans following intravenous OT infusion." | 3.78 | Proconvulsive effects of oxytocin in the generalized pentylenetetrazol mouse model are mediated by vasopressin 1a receptors. ( Loyens, E; Michotte, Y; Schallier, A; Smolders, I; Vermoesen, K, 2012) |
| "In pentylenetetrazole-induced seizure, the ethanol extract at doses of 250 and 1000mg/kg prolonged the onset of seizures." | 3.78 | UPLC-TOF-MS analysis of Galium spurium towards its neuroprotective and anticonvulsant activities. ( Aslan, M; Deliorman Orhan, D; Orhan, IE; Orhan, N; Süküroğlu, M, 2012) |
| "Taken together, sub-chronic pioglitazone treatment exerts anti-convulsant effects in intravenous and intraperitoneal pentylenetetrazole-induced seizures of mice probably through induction of constitutive nitric oxide synthase." | 3.78 | Sub-chronic treatment with pioglitazone exerts anti-convulsant effects in pentylenetetrazole-induced seizures of mice: The role of nitric oxide. ( Dehpour, AR; Ghorbani, H; Hassanipour, M; Hassanpour, S; Moezi, L; Shafaroodi, H; Zaeri, M, 2012) |
| " The purpose of this study was to determine the effects of arachidonyl-2'-chloroethylamide (ACEA-a highly selective cannabinoid CB1 receptor agonist) on the protective action of clonazepam, ethosuximide, phenobarbital, and valproate against pentylenetetrazole (PTZ)-induced clonic seizures in mice." | 3.78 | Effect of ACEA--a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model. ( Andres-Mach, M; Barcicka-Klosowska, B; Florek-Luszczki, M; Haratym-Maj, A; Luszczki, JJ; Zolkowska, D, 2012) |
| " Additionally, the anticonvulsant profile of CBDV (50-200 mg·kg(-1) ) in vivo was investigated in four rodent seizure models: maximal electroshock (mES) and audiogenic seizures in mice, and pentylenetetrazole (PTZ) and pilocarpine-induced seizures in rats." | 3.78 | Cannabidivarin is anticonvulsant in mouse and rat. ( Duncan, M; Futamura, T; Glyn, SE; Hill, AJ; Hill, TD; Jones, NA; Mercier, MS; Stephens, GJ; Stott, CG; Whalley, BJ; Williams, CM; Yamasaki, Y, 2012) |
| "), its effects on seizures, EEG epileptiform activity and EEG amplitude increases induced by two convulsive agents were evaluated and compared with the effects of carbamazepine." | 3.78 | The antidepressant sertraline prevents the behavioral and EEG changes induced in two animal models of seizures. ( Aldana, BI; Gómez, CD; Nekrassov, V; Sitges, M, 2012) |
| " We showed previously that hypoxia-induced seizures in a neonatal rat model induce rapid phosphorylation of serine-831 (S831) and Serine 845 (S845) sites of the AMPA receptor GluR1 subunit and later neuronal hyperexcitability and epilepsy, suggesting that seizure-induced posttranslational modifications may represent a novel therapeutic target." | 3.78 | Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures. ( Fitzgerald, EF; Huganir, RL; Hunganir, RL; Jensen, FE; Klein, PM; Rakhade, SN; Sun, H; Zhou, C, 2012) |
| "Wuling mycelia can delay the kindling and ameliorate the ability of learning in rats with pentylenetetrazole-induced epilepsy and the enhancement of neuronal histamine activity may be one of possible mechanisms." | 3.78 | [Effects of Wuling mycelia on pentylenetetrazole-induced epilepsy in rats]. ( Chen, GF; Hu, XY; Ren, GL; Zhang, LS, 2012) |
| "The effects of the halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine (3,5-DBr-D: -Tyr) were studied in rat models of stroke and epileptic seizures caused by middle cerebral artery occlusion (MCAo) through respective intracerebral injection of endothelin-1 (ET-1) and intraperitoneal (i." | 3.77 | Halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine produces beneficial effects in experimental stroke and seizures. ( Cao, W; Glushakov, A; Martynyuk, AE; Mecca, AP; Seubert, CN; Shah, HP; Shi, P; Sumners, C, 2011) |
| "These results show that the anesthetics propofol and 2,6-di-sec-butylphenol may be substituted in the para position with a 1-hydroxy-2,2,2-trifluoroethyl moiety and the resulting molecules have anticonvulsant activity in the 6 Hz model while exhibiting less toxicity (ataxia) than the parent 2,6-dialkylphenols." | 3.77 | The anticonvulsant effects of propofol and a propofol analog, 2,6-diisopropyl-4-(1-hydroxy-2,2,2-trifluoroethyl)phenol, in a 6 Hz partial seizure model. ( Baker, MT, 2011) |
| "The anticonvulsant activity of BmK AS, a sodium channel site 4-selective modulator purified from scorpion venom (Buthus martensi Karsch), was investigated in unanesthetized rats with acute pentylenetetrazole (PTZ)- and pilocarpine-induced seizures." | 3.77 | Anticonvulsant activity of BmK AS, a sodium channel site 4-specific modulator. ( Chen, L; Feng, Q; Ji, YH; Wang, Y; Weng, CC; Zhang, XY; Zhao, R; Zhu, HY, 2011) |
| " This study investigated the effect of the interaction of melatonin and agmatine on seizure susceptibility in the mouse model of pentylenetetrazole (PTZ)-induced clonic seizures." | 3.77 | The interaction of melatonin and agmatine on pentylenetetrazole-induced seizure threshold in mice. ( Dehpour, AR; Hojati, A; Moezi, L; Shafaroodi, H, 2011) |
| " The present study was designed to determine the anticonvulsant and/or proconvulsant effects of three antidepressants (citalopram, reboxetine, bupropion) against pilocarpine- and pentylenetetrazole-induced acute seizures in larval zebrafish and mice." | 3.77 | Assessment of the convulsant liability of antidepressants using zebrafish and mouse seizure models. ( Afrikanova, T; Clinckers, R; Crawford, AD; de Witte, PA; Esguerra, CV; Loyens, E; Massie, A; Michotte, Y; Schallier, A; Serruys, AS; Smolders, I; Vermoesen, K, 2011) |
| "The aim of present study was to examine the effects of the ethyl acetate fraction (EAF) from Platonia insignis on lipid peroxidation level, nitrite formation, and superoxide dismutase and catalase activities in rat striatum prior to pilocarpine-induced seizures as well as to explore its anticonvulsant activity in adult rats prior to pentylenetetrazole (PTZ)- and picrotoxin (PIC)-induced seizures." | 3.77 | Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models. ( Citó, AM; de Almeida, AA; de Freitas, RM; Júnior, JS; Saffi, J; Tomé, Ada R, 2011) |
| "The present study was performed to investigate whether or not carvedilol (a beta-adrenoreceptor antagonist) potentiates the anticonvulsive activity of gabapentin against ICES (Increasing current electroshock) and PTZ (Pentylenetetrazole) induced seizures in mice." | 3.77 | Influence of carvedilol on anticonvulsant effect of gabapentin. ( Goel, A; Goel, R; Kumar, Y, 2011) |
| "The physiologic response of wild-types and mice lacking both CK-B and UbCKmit (CK--/--mice) to pentylenetetrazole (PTZ)-induced seizures was measured using electroencephalography (EEG) recordings and behavioral monitoring." | 3.76 | Complete brain-type creatine kinase deficiency in mice blocks seizure activity and affects intracellular calcium kinetics. ( Oerlemans, F; Scheenen, WJ; Streijger, F; Van der Zee, CE; van Luijtelaar, G; Wieringa, B, 2010) |
| " CBD (1, 10, and 100 mg/kg) effects were also examined in vivo using the pentylenetetrazole model of generalized seizures." | 3.76 | Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo. ( Bevan, SA; Hill, AJ; Jones, NA; Smith, I; Stephens, GJ; Whalley, BJ; Williams, CM, 2010) |
| " The extract was submitted to a screening in anticonvulsant assays including NMDA-, kainic acid (KA)-, pentylenetetrazol (PTZ)- and bicuculline (BIC)-induced seizures in rats." | 3.76 | Anticonvulsant effects of Searsia dentata (Anacardiaceae) leaf extract in rats. ( Baldwin, RA; Jäger, AK; Niquet, J; Pedersen, ME; Stafford, GI; van Staden, J; Wasterlain, CG, 2010) |
| "In various animals methionine sulfoximine (MSO) induces tonic-clonic seizures resembling the most striking form of human epilepsies." | 3.76 | Selection of two lines of mice based on latency to onset of methionine sulfoximine seizures. ( Cloix, JF; Hévor, T; Martin, B; Tahi, Z, 2010) |
| " Similar to lithium, agmatine plays a protective role in the central nervous system against seizures and has been reported to enhance the effect of different antiepileptic agents." | 3.76 | Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway. ( Bahremand, A; Dehpour, AR; Ghasemi, A; Ghasemi, M; Hedayat, T; Khodadad, TK; Payandemehr, B; Rahimian, R; Ziai, P, 2010) |
| " Here, tonic-clonic seizures were induced with a convulsive dose of pentylenetetrazole (PTZ), and acute seizure recurrence was evoked with a subconvulsive dose of the drug." | 3.76 | Stress within the postseizure time window inhibits seizure recurrence. ( Cao, J; Duan, TT; Mao, RR; Tan, JW; Tian, M; Xu, L; Zhou, QX, 2010) |
| "For the acute study, in the maximal electroshock seizure model, the administration of 1 mg/kg of amlodipine resulted in the complete abolition of seizures in 33 percent of the mice, and this was increased to 67 percent with the administration of 4 mg/kg." | 3.76 | An experimental study of the anticonvulsant effect of amlodipine in mice. ( Sathyanarayana Rao, KN; Subbalakshmi, NK, 2010) |
| "Exposing Sprague-Dawley rat pups to very low, sub-convulsant doses of domoic acid (DOM) during perinatal development has been previously shown to result in seizure-like activity in adulthood similar to partial complex epilepsy in humans, and to produce cellular and molecular changes in the dentate gyrus and area CA-3 of the hippocampus." | 3.76 | Neonatal exposure to low-dose domoic acid lowers seizure threshold in adult rats. ( Bastlund, JF; Gill, DA; Reynolds, DS; Ryan, CL; Tasker, RA; Watson, WP, 2010) |
| " In the present study, using a model of clonic seizures induced with pentylenetetrazole (PTZ) in male Swiss mice, we investigated whether there is any interaction between lithium and either calcium channel blockers (CCBs: nifedipine, verapamil, and diltiazem) or N-methyl-D-aspartate (NMDA) receptor antagonists (ketamine and MK-801) in modulating seizure threshold." | 3.76 | Voltage-dependent calcium channel and NMDA receptor antagonists augment anticonvulsant effects of lithium chloride on pentylenetetrazole-induced clonic seizures in mice. ( Bahremand, A; Dehpour, AR; Ghasemi, A; Ghasemi, M; Heydarpour, P; Meskar, H; Nazarbeiki, S; Shafaroodi, H; Talab, SS; Ziai, P, 2010) |
| " The effects of the protein synthesis inhibitor cycloheximide (CHX) were examined on the expression and reconsolidation of pentylenetetrazole (PTZ) - induced kindled seizures and for comparative purposes, on the reconsolidation of conditioned fear response (conditioned freezing)." | 3.76 | The differential effects of protein synthesis inhibition on the expression and reconsolidation of pentylenetetrazole kindled seizures. ( Bidziński, A; Lehner, M; Maciejak, P; Płaźnik, A; Sobolewska, A; Szyndler, J; Turzyńska, D, 2010) |
| "2 s, while chemical seizures were induced by intraperitoneal injection of pentylenetetrazole at its CD97 dose (97% convulsive dose for the clonic phase)." | 3.76 | Influence of etoricoxib on anticonvulsant activity of phenytoin and diazepam in experimental seizure models in mice. ( Anitha, T; Gajera, K; Jayaraman, R; Joshi, VD; Ladani, K; Manisenthil, KT; Palei, NN, 2010) |
| " In acute study, seizures were induced by either pentylenetetrazole (PTZ) injection or maximal electroshock seizures, while in the chronic study, kindling was induced by injecting PTZ (30 mg/kg, s." | 3.76 | Effect of phosphamidon on convulsive behavior and biochemical parameters: modulation by progesterone and 4'-chlorodiazepam in rats. ( Arora, T; Banerjee, BD; Joshi, V; Mahajan, P; Mediratta, PK; Mehta, AK; Mehta, KD; Rathor, N; Sharma, AK; Sharma, KK, 2010) |
| " Hence, this study was conducted to evaluate the effect of curcumin against seizures, cognitive impairment and oxidative stress in pentylenetetrazole-induced kindling in rats." | 3.76 | Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model. ( Gupta, P; Gupta, YK; Mehla, J; Reeta, KH, 2010) |
| "In the present study, the effects of tramadol on pentylenetetrazole (PTZ)-induced seizures and involvement of nitric oxide (NO) were assessed in mice." | 3.76 | Involvement of the nitric oxide pathway in the anticonvulsant effect of tramadol on pentylenetetrazole-induced seizures in mice. ( Asghari-Roodsari, A; Dehpour, AR; Javadi-Paydar, M; Khodadad, TK; Lesani, A; Norouzi, A; Shirkhodaei, M, 2010) |
| "This study investigated the in vitro antioxidant activity of (E)-2-benzylidene-4-phenyl-1,3-diselenole (BPD), the anticonvulsant effect of BPD on seizures induced by pilocarpine (PC), pentylenetetrazole (PTZ) and 4-aminopyridine (4-AMP) and the mechanism involved." | 3.76 | Anticonvulsant effect of (E)-2-benzylidene-4-phenyl-1,3-diselenole in a pilocarpine model in mice. ( Bortolatto, CF; Jesse, CR; Nogueira, CW; Roman, SS; Wilhelm, EA, 2010) |
| "Our findings suggest that the induction of acute seizures with PTZ, but not with MES, in animals pretreated with pilocarpine (regardless of SE induction) might constitute an effective and valuable method to screen AEDs and to study mechanisms involved in pharmacoresistant temporal lobe epilepsy (TLE)." | 3.75 | Assessment of seizure susceptibility in pilocarpine epileptic and nonepileptic Wistar rats and of seizure reinduction with pentylenetetrazole and electroshock models. ( Albuquerque, C; Blanco, MM; Cavarsan, CF; dos Santos, JG; Hummel, M; Kohek, SR; Mello, LE; Perez-Mendes, P, 2009) |
| "Intraperitoneal injection of paxilline was sufficient to eliminate tonic-clonic seizures in picrotoxin-treated animals." | 3.75 | Anticonvulsant effects of the BK-channel antagonist paxilline. ( Barth, AL; Benedetti, BL; Sheehan, JJ, 2009) |
| "The present study evaluated the development of tolerance to the anticonvulsant effect of morphine in a mouse model of clonic seizures induced by pentylenetetrazole, and whether ultra-low doses of the opioid receptor antagonist naltrexone which selectively block G(s) opioid receptors were capable of preventing the observed tolerance." | 3.75 | Tolerance to the anticonvulsant effect of morphine in mice: blockage by ultra-low dose naltrexone. ( Dehpour, AR; Ghahremani, MH; Ghasemi, M; Rafiei-Tabatabaei, N; Riazi, K; Roshanpour, M, 2009) |
| "To characterize the interactions between levetiracetam and the antiepileptic drugs gabapentin, tiagabine, and vigabatrin in suppressing pentylenetetrazole-induced clonic seizures in mice, type II isobolographic analysis was used." | 3.75 | Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis. ( Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N; Sielski, M, 2009) |
| "Morphine dependence increased a PTZ-induced long-term potentiation (LTP) of the population spike in CA1 in vitro." | 3.75 | Morphine dependence increases the response to a brief pentylenetetrazol administration in rat hippocampal CA1 in vitro. ( Fathollahi, Y; Jafarzadeh, Z; Omrani, A; Salmani, ME; Salmanzadeh, F; Semnanian, S, 2009) |
| "This study was designed so as to characterize the interactions between levetiracetam (LEV) and the conventional antiepileptic drugs (AEDs) clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced clonic seizures in mice by use of type II isobolographic analysis." | 3.75 | Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model. ( Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2009) |
| "TNBS-induced colitis increased seizure susceptibility to a subconvulsive dose of pentylenetetrazole; the immunomodulator thalidomide was protective." | 3.75 | Intestinal inflammation and seizure susceptibility: understanding the role of tumour necrosis factor-alpha in a rat model. ( Avti, PK; Chakrabarti, A; Khanduja, KL; Medhi, B; Prakash, A, 2009) |
| " 3,5-DBr-L-Phe was also given as a single bolus prior to pentylenetetrazole (PTZ) injection to induce seizures or prior to the administration of the N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine (MK-801) to cause disruption of prepulse inhibition (PPI) of startle (sensorimotor gating deficit)." | 3.75 | Efficacy of 3,5-dibromo-L-phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit. ( Cao, W; Glushakov, AV; Martynyuk, AE; Mecca, AP; Seubert, CN; Shah, HP; Shi, P; Sumners, C, 2009) |
| " Therefore, we determined the effects of two Rho-kinase inhibitors, Y-27632 and fasudil, on seizures induced by pentylenetetrazole (PTZ) or maximal electroconvulsive shock (MES)." | 3.74 | Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice. ( Büyükafşar, K; Inan, S, 2008) |
| "BmK IT2 showed anticonvulsant activity as it inhibited the widespread seizures induced by PTZ and pilocarpine-induced SE in rats." | 3.74 | Anticonvulsant effect of BmK IT2, a sodium channel-specific neurotoxin, in rat models of epilepsy. ( Ji, YH; Jiang, LL; Shu, XQ; Weng, CC; Yang, J; Zhang, JW; Zhang, XY; Zhao, R, 2008) |
| " In ovariectomized Swiss mice, the threshold for seizures induced by intravenous infusion of pentylenetetrazole was determined after treatment with progesterone (25, 50, or 75 mg/kg, given subcutaneously 6h before seizure testing) or vehicle." | 3.74 | Role of nitric oxide in the anticonvulsive effect of progesterone. ( Dehpour, AR; Gholipour, T; Jabbarzadeh, A; Nezami, BG; Rasouli, A; Riazi, K; Sharifzadeh, M, 2008) |
| " Isobolographic analysis was used in two mouse experimental models of epilepsy: the maximal electroshock seizure threshold test and pentylenetetrazole-induced seizures." | 3.74 | Isobolographic and behavioral characterizations of interactions between vigabatrin and gabapentin in two experimental models of epilepsy. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2008) |
| "To characterize the type of interactions between vigabatrin (VGB) and tiagabine (TGB) -- two newer antiepileptic drugs influencing GABA-ergic neurotransmitter system, the isobolographic analysis was used in two experimental models of epilepsy: the maximal electroshock seizure threshold (MEST) test and pentylenetetrazole (PTZ)-induced seizures in mice." | 3.74 | Isobolographic characterization of interactions between vigabatrin and tiagabine in two experimental models of epilepsy. ( Czuczwar, SJ; Luszczki, JJ, 2007) |
| "The anticonvulsant effects of benzyl- and benzhydryl ureides in mice models of seizures (maximal electroshock seizure test, pentylenetetrazol test, picrotoxin-induced seizure test) and the influence on spontaneous locomotor activity has been assessed." | 3.74 | Evaluation of anticonvulsant and analgesic effects of benzyl- and benzhydryl ureides. ( Gütschow, M; Kubacka, M; Librowski, T; Meusel, M; Müller, CE; Scolari, S, 2007) |
| " We studied the potential anticonvulsant effect of thalidomide: Different doses of thalidomide were tested against seizures induced by 50 mg/kg or 70 mg/kg of pentylenetetrazole (PTZ); the anticonvulsant effect of thalidomide was also compared with that of valproic acid." | 3.74 | Thalidomide inhibits pentylenetetrazole-induced seizures. ( Calderon, A; Palencia, G; Sotelo, J, 2007) |
| " We have investigated the effects of mirtazapine on pentylenetetrazole (PTZ)- and maximal electroconvulsive shock (MES)-induced seizures in mice." | 3.74 | Mirtazapine does not affect pentylenetetrazole- and maximal electroconvulsive shock-induced seizures in mice. ( Kayir, H; Sezer, Z; Uzbay, TI; Yilmaz, I, 2007) |
| "Seizures were induced with pentylenetetrazole (PTZ)." | 3.74 | A large-scale mutagenesis screen to identify seizure-resistant zebrafish. ( Baraban, SC; Castro, PA; Chege, S; Dinday, MT; Guyenet, S; Taylor, MR, 2007) |
| " With this background, the present study was designed to explore the possible effect of nimesulide (a preferential COX-2 inhibitor) against pentylenetetrazol (PTZ)-induced kindling epilepsy in mice." | 3.74 | Neuroprotective effect of nimesulide, a preferential COX-2 inhibitor, against pentylenetetrazol (PTZ)-induced chemical kindling and associated biochemical parameters in mice. ( Dhir, A; Kulkarni, SK; Naidu, PS, 2007) |
| "Both opioid and cannabinoid CB(1) receptors may be involved in the dramatic increase in pentylenetetrazole-induced seizure threshold in cholestasis." | 3.74 | Elevation of pentylenetetrazole-induced seizure threshold in cholestatic mice: interaction between opioid and cannabinoid systems. ( Dehpour, AR; Ghasemi, M; Shafaroodi, H, 2008) |
| ") against pentylenetetrazole (PTZ)-, picrotoxin (PCT)- and bicuculline (BCL)-induced seizures in mice." | 3.74 | Anticonvulsant property of Sutherlandia frutescens R. BR. (variety Incana E. MEY.) [Fabaceae] shoot aqueous extract. ( Ojewole, JA, 2008) |
| " The threshold to generalized clonic seizures induced by timed intravenous infusion of pentylenetetrazole (PTZ) was used as an index of seizure propensity." | 3.74 | Seizure susceptibility alteration following reversible cholestasis in mice: Modulation by opioids and nitric oxide. ( Dehpour, AR; Doratotaj, B; Gholipour, T; Honar, H; Jannati, A; Nik, HH; Noorian, AR; Riazi, K; Shariftabrizi, A, 2008) |
| "To determine the changes of mossy fiber sprouting in hippocampus of pre-kindling and post-kindling rats of chronic epilepsy induced by pentylenetetrazole (PTZ)." | 3.74 | [Changes of mossy fiber sprouting in hippocampus of pentylenetetrazole kindling rats]. ( Cai, XF; Chen, JM; Guo, TH; Ma, YF; Tian, FF; Yao, FH, 2007) |
| " Some selected compounds were assayed against seizures induced by pentylenetetrazole (PTZ) and strychnine in mice." | 3.74 | Synthesis and preliminary evaluation of some substituted coumarins as anticonvulsant agents. ( Al-Eryani, YA; Amin, KM; Rahman, DE, 2008) |
| " Lower doses of valproate and carbamazepine were required to prevent hyperactivity compared to doses required to block tonic-clonic seizures induced by pentylenetetrazole." | 3.73 | Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania. ( Arban, R; Brackenborough, K; Gerrard, P; Large, C; Maraia, G; Wilson, A; Winyard, L, 2005) |
| "The anticonvulsant activity of acetone extract of the seeds of Heracleum persicum (Umbelliferae) was examined against pentylenetetrazole (PTZ) and maximal electroshock (MES)-induced seizures in mice." | 3.73 | Anticonvulsant activity of Heracleum persicum seed. ( Kamalinejad, M; Moaied, S; Sayyah, M, 2005) |
| "5 hours later by administration of saline vehicle or a regimen of bicuculline (1 mg/kg, sc), a GABA(A) receptor antagonist, which does not produce any intrinsic effects on seizures." | 3.73 | Actions at GABA(A) receptors in the hippocampus may mediate some antiseizure effects of progestins. ( Frye, CA; Rhodes, ME, 2005) |
| "NEF inhibited electroshock-induced seizures at nontoxic doses, whereas it had no effect on seizures chemically induced by pentylenetetrazole, bicuculline, picrotoxin, strychnine, or N-methyl-D-aspartate." | 3.73 | Anticonvulsant properties of the novel nootropic agent nefiracetam in seizure models of mice and rats. ( Kitano, Y; Komiyama, C; Makino, M; Sakurada, S; Takasuna, K; Takazawa, A, 2005) |
| " To test this idea, we assessed the effects of chronic administration (via osmotic minipump) of the selective NET inhibitor reboxetine on flurothyl-induced seizures in mice." | 3.73 | The effects of chronic norepinephrine transporter inactivation on seizure susceptibility in mice. ( Ahern, TH; Eagles, DA; Javors, MA; Liles, LC; Martillotti, J; Mitchell, HA; Weinshenker, D, 2006) |
| " Anticonvulsant and acute neurotoxic adverse effect profiles of combinations of GBP and TGB with other AEDs at fixed ratios of 1:3, 1:1 and 3:1 were investigated in pentylenetetrazole (PTZ)-induced seizures and the chimney test (as a measure of motor impairment) in mice so as to identify optimal combinations." | 3.73 | Isobolographic characterisation of interactions among selected newer antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model. ( Czuczwar, SJ; Luszczki, JJ, 2005) |
| "Anticonvulsant activity of allopregnanolone, a neurosteroid allosterically modulating GABA(A) receptor was tested in a model of motor seizures elicited by pentetrazol in immature rats." | 3.73 | Anticonvulsant action of allopregnanolone in immature rats. ( Haugvicová, R; Kasal, A; Mares, P; Mikulecká, A, 2006) |
| " This study evaluated the neuroprotective activity of citronellol on pentylenetetrazol- and picrotoxin-induced convulsions and maximal electroshock-induced seizures in mice." | 3.73 | Study of anticonvulsant effect of citronellol, a monoterpene alcohol, in rodents. ( Araújo, DA; Cruz, JS; de Almeida, RN; de Sousa, DP; Gonçalves, JC; Quintans-Júnior, L, 2006) |
| " Pentylenetetrazole (PTZ)-induced seizures were used to evaluate the anticonvulsant effect of drugs." | 3.73 | Modulation of pentylenetetrazole-induced seizures and oxidative stress parameters by sodium valproate in the absence and presence of N-acetylcysteine. ( Pillai, KK; Uma Devi, P; Vohora, D, 2006) |
| ") against pentylenetetrazole (PTZ)-, picrotoxin (PCT)- and bicuculline (BCL)-induced seizures in mice." | 3.73 | Anticonvulsant effect of Persea americana Mill (Lauraceae) (Avocado) leaf aqueous extract in mice. ( Amabeoku, GJ; Ojewole, JA, 2006) |
| "0 mg/kg) as well as increasing the threshold to electrically- and pentylenetetrazole-induced seizures (TID(10)s 7." | 3.73 | In vivo characterisation of the small-conductance KCa (SK) channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) as a potential anticonvulsant. ( Anderson, NJ; Slough, S; Watson, WP, 2006) |
| "The long-term effect of three of the most widely used antiepileptic drugs at relevant doses on the hearing decline that accompanies pentylenetetrazole (PTZ)-induced experimental epilepsy was investigated here, and compared with the effect of vinpocetine (VPC), which is a drug with antiepileptic potential." | 3.73 | Additive effects of antiepileptic drugs and pentylenetetrazole on hearing. ( Nekrassov, V; Sitges, M, 2006) |
| "6 microg/microl) effectively prevented seizures induced by the unilateral GABAergic blockade of Area tempestas (bicuculline, 0." | 3.73 | Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae). ( Beleboni, Rde O; Coutinho-Netto, J; Cunha, AO; dos Santos, WF; Gelfuso, EA; Liberato, JL; Mortari, MR, 2006) |
| "Isobolographic analysis was used to characterize the interactions between stiripentol (STP) and clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced clonic seizures in mice." | 3.73 | Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2006) |
| "This work evaluates the seizure susceptibility of nai;ve female Wistar Audiogenic rats (WARs), a genetic model of reflex epilepsy in which seizures are induced by high-intensity sound stimulation (120 dB SPL), to other pro-convulsive stimuli: transauricular electroshock (ES), pentylenetetrazole (PTZ) and pilocarpine (PILO)." | 3.72 | Assessment of the seizure susceptibility of Wistar Audiogenic rat to electroshock, pentyleneterazole and pilocarpine. ( Doretto, MC; Magalhães, LH; Moraes, MF; Scarlatelli-Lima, AV, 2003) |
| "The objective of this study was to evaluate the interaction of the novel antiepileptic drug (AED), topiramate (TPM), with conventional AEDs against amygdala-kindled seizures in rats and pentylenetetrazol-induced convulsions in mice." | 3.72 | Effect of topiramate on the anticonvulsant activity of conventional antiepileptic drugs in two models of experimental epilepsy. ( Borowicz, KK; Czuczwar, SJ; Duda, AM; Luszczki, JJ, 2003) |
| " Anticonvulsant effects were evaluated against seizures induced by 14 mg kg(-1) of 4-aminopyridine (4-AP) and by 110 mg kg(-1) of pentylenetetrazole (PTZ), and neurotoxicity by the rotarod test." | 3.72 | Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial? ( Amat, G; Armijo, JA; Cuadrado, A, 2003) |
| "Seizures were induced by intraperitoneal administration of pentylenetetrazol (PTZ), picrotoxin (PIC), or kainic acid (KA) respectively." | 3.72 | Increase in drug-induced seizure susceptibility of transgenic mice overexpressing GABA transporter-1. ( Fei, J; Guo, LH; Ma, YH; Mei, ZT; Zhao, WJ, 2003) |
| "The study investigated the activity of harmane on maximal electroshock seizures (MES) and seizures induced by pentilentetrazole (PTZ) in mice." | 3.72 | Effect of harmane on the convulsive threshold in epilepsy models in mice. ( Aricioglu, F; Berkman, K; Korcegez, E; Yillar, O, 2003) |
| " After a single injection of PTZ at a dose evoking clonic-tonic seizures, PBN did not modify either the formation of free hydroxyl radicals measured by the levels of 2,3-dihydroxybenzoic acid (DHBA) and 2,5-DHBA or the susceptibility to PTZ." | 3.72 | The role of superoxide dismutase and alpha-tocopherol in the development of seizures and kindling induced by pentylenetetrazol - influence of the radical scavenger alpha-phenyl-N-tert-butyl nitrone. ( Keilhoff, G; Krug, M; Rauca, C; Wiswedel, I; Zerbe, R, 2004) |
| " The aim of this study was to evaluate the profile of interactions between FBM and four conventional antiepileptic drugs (AEDs): clonazepam (CZP), ethosuximide (ESM), phenobarbital (PB), and valproate (VPA), in pentylenetetrazole (PTZ)-induced convulsions in mice, a model of myoclonic seizures in humans." | 3.72 | Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ, 2004) |
| " In a prospective trial in dogs with newly diagnosed epilepsy, ELB 138 markedly reduced seizure frequency and severity without significant difference to standard treatments (phenobarbital or primidone) but was much better tolerated than the standard drugs." | 3.72 | Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures. ( Löscher, W; Potschka, H; Rieck, S; Rundfeldt, C; Tipold, A, 2004) |
| " In the present study, we induced lithium and pilocarpine status epilepticus (SE) in 10-day-old (P10) rats." | 3.71 | Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures. ( Dubé, C; Koning, E; Nehlig, A, 2002) |
| "Perimenstrual catamenial epilepsy may in part be due to withdrawal of the endogenous progesterone-derived neurosteroid allopregnanolone that potentiates gamma-aminobutyric acidA (GABA(A)) receptor-mediated inhibition." | 3.71 | Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2001) |
| "Perimenstrual catamenial epilepsy, the increase in seizure frequency that some women with epilepsy experience near the time of menstruation, may in part be related to withdrawal of the progesterone metabolite allopregnanolone, an endogenous anticonvulsant neurosteroid that is a potent positive allosteric gamma-aminobutyric acidA (GABA(A)) receptor modulator." | 3.71 | Neurosteroid withdrawal model of perimenstrual catamenial epilepsy. ( Kim, HY; Reddy, DS; Rogawski, MA, 2001) |
| "In mice VGD afforded complete protection against maximal electroshock (MES)-, pentylenetetrazole-, picrotoxin-, and bicuculline-induced seizures and 6-Hz "psychomotor" seizures with median effective dose (ED50) values of 151, 132, 275, 248, and 237 mg/kg, respectively." | 3.71 | Anticonvulsant profile of valrocemide (TV1901): a new antiepileptic drug. ( Bialer, M; Isoherranen, N; White, HS; Woodhead, JH, 2001) |
| "The anticonvulsive activity of nociceptin, endogenous OP4 receptors agonist was investigated in pentylenetetrazole (PTZ), N-methyl D-aspartic acid (NMDA), bicucculine (BCC) and electrically evoked seizure models of experimental epilepsy." | 3.71 | Nociceptin, OP4 receptor ligand in different models of experimental epilepsy. ( Gustaw, K; Rubaj, A; Sieklucka-Dziuba, M; Zgodzinski, W, 2002) |
| "Based on these findings, both opioid receptors and nitric oxide may be involved in the dramatic increase in pentylenetetrazole-induced seizure threshold in cholestasis." | 3.71 | The additive effect of opioids and nitric oxide in increasing pentylenetetrazole-induced seizure threshold in cholestatic mice. ( Dehpour, AR; Homayoun, H; Sayyah, M, 2002) |
| "The effect of trans-resveratrol (resveratrol), a polyphenolic compound with potent antioxidant activity, was investigated against pentylenetetrazole (PTZ) induced seizures in rats." | 3.71 | Protective effect of resveratrol against pentylenetetrazole-induced seizures and its modulation by an adenosinergic system. ( Chaudhary, G; Gupta, YK; Srivastava, AK, 2002) |
| "Action of ethosuximide (ESI) against two types of experimental seizures elicited by systemic administration of pentylenetetrazol (PTZ) and characterized by spike-and-wave activity in the EEG was studied in immature rats 18 and 25 days old, i." | 3.70 | Ontogeny of ethosuximide action against two seizure models in rats is different. ( Mares, P, 1998) |
| "The protective and adverse effect potentials of levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide) in rodent models of seizures and epilepsy were compared with the profile of several currently prescribed and newly developed antiepileptic drugs." | 3.70 | Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. ( Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E, 1998) |
| "The efficacy of Flunarizine (FLU), a calcium channel blocker, in combination with conventional antiepileptic drugs, phenytoin (PHT), carbamazepine (CBZ), sodium valproate (VPA), and ethosuximide (ESM), at ED50 doses, were examined for protective effects against maximal electroshock seizures (MES) and pentylenetetrazol (PTZ) induced seizures in mice." | 3.70 | Additive anticonvulsant effect of flunarizine and sodium valproate on electroshock and chemoshock induced seizures in mice. ( David, J; Joseph, S; Joseph, T, 1998) |
| "The purpose of this study was to test the hypothesis that a ketogenic diet would increase the resistance of rats to pentylenetetrazole (PTZ)-induced seizures and to understand the relation of ketonemia to seizure resistance." | 3.70 | A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat. ( Bough, KJ; Eagles, DA, 1999) |
| "In this study, the effect of an essential oil of Eugenia caryophyllata (Myrtaceae), an antiepileptic remedy in Iranian folk medicine, against seizures induced by maximal electroshock (MES) or pentylenetetrazole (PTZ) in male mice was studied." | 3.70 | Evaluation of the anticonvulsant activity of the essential oil of Eugenia caryophyllata in male mice. ( Javadi, M; Kamalinejad, M; Majzoob, S; Pourgholami, MH; Sayyah, M, 1999) |
| "This study was designed to evaluate the blood-brain barrier permeability characteristics of the WAG/Rij strain of rats that are an ideal model for human absence epilepsy, in controls and pentylenetetrazole-induced seizures conditioned to Evans blue-albumin." | 3.70 | Absence epilepsy and regional blood-brain barrier permeability: the effects of pentylenetetrazole-induced convulsions. ( Ates, N; Esen, N; Ilbay, G, 1999) |
| "We tested the sensitivity of PrPc knockout mice to seizures induced by single convulsant or repeated subconvulsant (kindling) doses of pentylenetetrazol (PTZ), and to status epilepticus (SE) induced by kainic acid or pilocarpine." | 3.70 | Increased sensitivity to seizures in mice lacking cellular prion protein. ( Amaral, OB; Brentani, RR; Cavalheiro, EA; Izquierdo, I; Martins, VR; Rockenbach, IC; Roesler, R; Walz, R, 1999) |
| " In order to further evaluate the role of adenosine in seizure activity, we monitored adenosine and its major biochemical metabolites inosine, xanthine, and hypoxanthine in the dorsal hippocampus by in vivo microdialysis before and during the induction of generalized seizures." | 3.70 | Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats. ( Aden, U; Berman, RF; Fredholm, BB; O'Connor, WT, 2000) |
| "Perimenstrual catamenial epilepsy, the exacerbation of seizures in association with menstruation, may in part be due to withdrawal of the progesterone metabolite allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), an endogenous anticonvulsant neurosteroid that is a positive allosteric modulator of gamma-aminobutyric acid(A) receptors." | 3.70 | Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2000) |
| "The interaction of 7-nitroindazole (7-NI), a nitric oxide synthase (NOS) inhibitor, with the protective activity of conventional antiepileptics against pentylenetetrazol (PTZ)-induced seizures was tested in mice." | 3.70 | 7-Nitroindazole, a nitric oxide synthase inhibitor, enhances the anticonvulsive action of ethosuximide and clonazepam against pentylenetetrazol-induced convulsions. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Luszczki, J, 2000) |
| "The effects of muscimol, amino-oxyacetic acid (AOAA), diamino-N-butyric acid (DABA), bicuculline, picrotoxin, diazepam and phenobarbitone on the protective effect of clonidine against pentylenetetrazol-induced seizures were studied in mice." | 3.69 | gamma Aminobutyric acid mediation of the anticonvulsant effect of clonidine on pentylenetetrazol-induced seizures in mice. ( Amabeoku, G; Bwakura, E; Chikuni, O, 1994) |
| " In addition, the plant extract delayed the onset of PTZ forelimb clonus, and generalized limbic seizures induced by kainic acid." | 3.69 | Effects of an ethanolic extract of Desmodium adscendens on central nervous system in rodents. ( Baldy-Moulinier, M; N'gouemo, P; Nguemby-Bina, C, 1996) |
| " GYKI 52466 was also protective against seizures and lethality induced by 4-aminopyridine, kainate and AMPA, but not by NMDA, whereas NBQX was ineffective in these chemoconvulsant tests." | 3.68 | Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models. ( Donevan, SD; Rogawski, MA; Yamaguchi, S, 1993) |
| "The anticonvulsant effect of either phenobarbital or dilantin was potentiated by exogenous glycine in DBA/2 audiogenic seizure mice and in 3-mercaptopropionic acid-induced seizures." | 3.67 | Glycine potentiates the action of some anticonvulsant drugs in some seizure models. ( Lajtha, A; Toth, E, 1984) |
| "The seizure sensitive Mongolian gerbil, a genetic model of epilepsy, has been used to investigate the effects of prior spontaneous seizures on the threshold for pentylenetetrazole (PTZ) and maximum electroshock (MES) induced convulsions." | 3.67 | The effect of spontaneous seizures on pentylenetetrazole and maximum electroshock induced seizures in the Mongolian gerbil. ( Lee, RJ; Lomax, P, 1984) |
| " The compounds were screened in mice for their ability to antagonize maximal electroshock- and bicuculline-induced seizures; neurotoxicity was evaluated in the rotorod test." | 3.67 | Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy. ( Biziere, K; Brochard, J; Brodin, R; Chambon, JP; Hallot, A; Merlier, J, 1986) |
| "The anticonvulsant efficacy of the GABAmimetic drugs cetyl GABA, progabide and THIP (4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridine-3-ol) was studied against minor (myoclonic) and major (generalized tonic-clonic) seizures in gerbils as well as against maximal electroshock and s." | 3.67 | Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states. ( Löscher, W, 1985) |
| "Trimethadione was compared with chlordiazepoxide for anti-anxiety activity in two behavioral tests known to predict the anxiolytic action of drugs." | 3.66 | Comparison of the actions of trimethadione and chlordiazepoxide in animal models of anxiety and benzodiazepine receptor binding. ( Bennett, DA; Brugger, S; Dutta, P; Fielding, S; Geyer, H; Lal, H, 1982) |
| " Catalepsy and analgesia were found in varying degrees after maximal electroshock (MES), metrazol, picrotoxin, and Ro 5-3663 activated seizures." | 3.66 | Convulsant-specific architecture of the postictal behavior syndrome in the rat. ( Kofman, O; Mintz, M; Myslobodsky, M, 1981) |
| "Midbrain tegmental lesions, which prevent the hindlimb extensor (HLE) component of maximal electroshock seizures (MES), were found to have no effect on the electroshock, flurothyl, or pentylenetetrazol (PTZ) seizures thresholds." | 3.66 | Antagonism of experimentally induced tonic seizures following a lesion in the midbrain tegmentum. ( Browning, RA; Simonton, RL; Turner, FJ, 1981) |
| " Pentylenetetrazol was given intraveneously in 50-mg increments or 4% enflurane was inspired until grand mal seizures occurred spontaneously or were triggered by photic or auditory stimuli." | 3.65 | Effects of acute and chronic paleocerebellar stimulation on experimental models of epilepsy in the cat: studies with enflurane, pentylenetetrazol, penicillin, and chloralose. ( Bickford, RG; Burchiel, KJ; Myers, RR; Stockard, JJ, 1975) |
| "Epilepsy is a neurological disorder affecting both children and adults, and many aspects of this disease are still poorly understood." | 3.01 | Zebrafish as an Innovative Tool for Epilepsy Modeling: State of the Art and Potential Future Directions. ( D'Amora, M; De Angelis, F; Faraguna, U; Galgani, A; Giorgi, FS; Marchese, M; Tantussi, F, 2023) |
| " Consequently, the aim of the current study was to comparatively evaluate the pharmacokinetic (PK) and pharmacodynamic (PD anticonvulsant activity) profile of EMC and IPC individual enantiomers." | 2.79 | Enantioselective pharmacodynamic and pharmacokinetic analysis of two chiral CNS-active carbamate derivatives of valproic acid. ( Bialer, M; Finnell, RH; Mawasi, H; McDonough, JH; Shekh-Ahmad, T; Wlodarczyk, BJ; Yavin, E, 2014) |
| "Since 1993, over 20 new anti-seizure drugs (ASDs) have been identified in well-established animal seizure and epilepsy models and subsequently demonstrated to be clinically effective in double-blinded, placebo-controlled clinical trials in patients with focal onset seizures." | 2.66 | Validated animal models for antiseizure drug (ASD) discovery: Advantages and potential pitfalls in ASD screening. ( Barker-Haliski, M; Steve White, H, 2020) |
| "Seizures are a combination of electrical and behavioral events that can induce biochemical, molecular, and anatomic changes." | 2.66 | Experimental Models for the Discovery of Novel Anticonvulsant Drugs: Focus on Pentylenetetrazole-Induced Seizures and Associated Memory Deficits. ( Adem, A; Alachkar, A; Frank, A; Ojha, SK; Sadek, B; Sadeq, A; Stark, H, 2020) |
| "Patients with epilepsy are often affected by not only seizures but also a variety of cognitive and psychiatric comorbidities that further impair their quality of life." | 2.61 | [Neurobehavioral Comorbidities in Pentylenetetrazol-kindled Mice and Role of the α4β2 Nicotinic Acetylcholine Receptor]. ( Takechi, K, 2019) |
| "Epilepsy is characterized by recurrent seizures, which are caused by excessive discharges from cerebral neurons." | 2.48 | [Impaired memory following repeated pentylenetetrazol treatments in kindled mice]. ( Araki, H; Kawasaki, H; Suemaru, K; Takechi, K, 2012) |
| "Trisomy 21 was first described as a syndrome in the middle of the nineteenth century and associated to a chromosomic anomaly one hundred years later: the most salient feature of this syndrome is a mental retardation of variable intensity." | 2.46 | [New perspectives on molecular and genic therapies in Down syndrome]. ( Delabar, JM, 2010) |
| "Furthermore, testosterone's antiseizure effects may involve actions of its 5alpha-reduced metabolite and neuroactive steroid, 5alpha-androstane-3alpha,17beta-diol (3alpha-diol)." | 2.42 | Androgens in the hippocampus can alter, and be altered by, ictal activity. ( Frye, CA; Rhodes, ME, 2004) |
| "GABA related drugs acting on PTZ clonic seizures tend to induce sedation and muscle hypotonia." | 2.41 | Do preclinical seizure models preselect certain adverse effects of antiepileptic drugs. ( Meldrum, B, 2002) |
| " Further, these stimuli can be easily quantified through dose-response analysis." | 2.36 | Behavioral analogues of anxiety. Animal models. ( Emmett-Oglesby, MW; Lal, H, 1983) |
| "Epilepsy is a common neurological disorder affecting more than 70 million people worldwide." | 1.91 | ( Gao, Y; Jiang, X; Liang, X; Liu, W; Lu, H; Wang, N; Xing, B; Xu, X; Zhao, Q; Zhou, L, 2023) |
| "Liraglutide is a glucagon-like peptide-1 (GLP-1) analogue that is used to treat type-2 diabetes mellitus." | 1.91 | The Anti-Seizure Effect of Liraglutide on Ptz-Induced Convulsions Through its Anti-Oxidant and Anti-Inflammatory Properties. ( Erbas, O; Erdogan, A; Erdogan, MA, 2023) |
| "Epilepsy is a disease which affects between 1 and 2% of the population, and a large proportion of these people do not react to currently available anticonvulsant medications, indicating the need for further research into novel pharmacological therapies." | 1.91 | Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions. ( Erbas, O; Erdogan, A; Erdogan, MA; Gurgul, S, 2023) |
| "Nocturnal epilepsy is a neurological disease that has a significant effect on sleep." | 1.91 | Effect of valproate on sleep patterns disturbed by epilepsy. ( Ayala-Guerrero, F; Castro-Domínguez, D; Gutiérrez-Chávez, CA; Mateos-Salgado, EL; Mexicano-Medina, G, 2023) |
| "PTZ was used for the induction of seizures." | 1.91 | Chronic stress but not acute stress decreases the seizure threshold in PTZ-induced seizure in mice: role of inflammatory response and oxidative stress. ( Amini-Khoei, H; Bijad, E; Dehkordi, HT; Korrani, MS; Saghaei, E, 2023) |
| "Early onset of PTZ-induced seizure-like behavioural scores, the heightened intensity of seizure and reduced latency in different scores were found in PG and CPFX-administered groups." | 1.91 | Antibiotics modulate frequency and early generation of epileptic seizures in zebrafish. ( Ramachandran, B; Sivarajan, D, 2023) |
| "Inflammation is considered to be involved in epileptogenesis." | 1.91 | Inflammation as a target for the treatment of fever-associated epilepsy in zebrafish larvae. ( Liang, W; Shen, D; Shen, Y; Sui, J; Wang, J; Wu, Y; Yun, F; Zhang, Q; Zhou, J, 2023) |
| "Tacrolimus pre-treatment dose-dependently resulted in lesser seizure severity according to Racine's scale, delayed start-up latency of the first myoclonic jerk and attenuated the spike percentages detected by EEG in seizure-induced rats." | 1.91 | Immunosuppressant Tacrolimus Treatment Delays Acute Seizure Occurrence, Reduces Elevated Oxidative Stress, and Reverses PGF2α Burst in the Brain of PTZ-Treated Rats. ( Egilmez, CB; Erbas, O; Erdogan, MA; Pazarlar, BA, 2023) |
| "CA6 and CA12 (p." | 1.91 | Anticonvulsant Profile of Selected Medium-Chain Fatty Acids (MCFAs) Co-Administered with Metformin in Mice in Acute and Chronic Treatment. ( Nieoczym, D; Pieróg, M; Samorek-Pieróg, M; Socała, K; Wlaź, P; Wyska, E, 2023) |
| "While CCI mice have no change in seizure susceptibility at 7d post-injury (dpi), at 70dpi they have reduced latency to PTZ-induced seizure onset, higher seizure frequency and longer seizure duration." | 1.91 | Delayed treatment with ceftriaxone reverses the enhanced sensitivity of TBI mice to chemically-induced seizures. ( Burns, MP; Harvey, AC; Longo, BM; Main, BS; Romariz, SAA, 2023) |
| "Epilepsy is a chronic brain disorder characterized by unprovoked and recurrent seizures, of which 60% are of unknown etiology." | 1.91 | Seizure-induced increase in microglial cell population in the developing zebrafish brain. ( Ameli, C; Cordero-Maldonado, ML; Crawford, AD; Donato, C; Martins, TG; Mombaerts, L; Peri, F; Skupin, A; Soliman, R, 2023) |
| "Epilepsy is a prevalent neurological disease, affecting approximately 1-2% of the global population." | 1.91 | Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish. ( Benvenutti, R; Chitolina, R; Herrmann, AP; Linazzi, A; Marcon, M; Piato, A; Reis, CG; Stahlhofer-Buss, T, 2023) |
| "Dravet syndrome is characterized by multiple seizure types: generalized tonic-clonic, focal, myoclonic, and absence seizures." | 1.72 | Stiripentol inhibits spike-and-wave discharges in animal models of absence seizures: A new mechanism of action involving T-type calcium channels. ( Heulard, I; Reversat, L; Riban, V; Si Hocine, H; Verleye, M, 2022) |
| "Among models of acutely evoked seizures, whereas anticonvulsive effects of soticlestat were identified in Frings mice, a genetic model of audiogenic seizures, it was found ineffective in MES, acute PTZ seizures, and 6-Hz seizures." | 1.72 | Anticonvulsive properties of soticlestat, a novel cholesterol 24-hydroxylase inhibitor. ( Fujimoto, S; Hasegawa, S; Kondo, S; Metcalf, CS; Miyamoto, M; Nishi, T; Sunahara, E; Watanabe, S; White, HS, 2022) |
| "A coil method was used to detect motor seizures consisting of small amplitude 19-21 Hz muscle contractions." | 1.72 | Detection of pentylenetetrazol-induced seizure activity in the 19-21 Hz beta range using a magnetic coil induction method. ( Chang, WJ; Lu, HC; Shyu, BC; Wei Huang, AC, 2022) |
| "We optimized a locomotor-based seizure assay in zebrafish with pentylenetetrazol (PTZ) as the pharmacological proconvulsant to generate a therapeutic window in which proconvulsant-treated zebrafish larvae could be discriminated from a non-treated control." | 1.72 | Optimization of a locomotion-based zebrafish seizure model. ( Luyten, W; Panda, SK; Shaw, PAG; Stanca, A, 2022) |
| "Epileptic seizures are associated with the overproduction of free radicals in the brain leading to neuronal cell death." | 1.72 | The Effects of Vitamin D3 and Melatonin Combination on Pentylenetetrazole- induced Seizures in Mice. ( Dehdashtian, E; Hosseinzadeh, A; Jafari-Sabet, M; Mehrzadi, S, 2022) |
| "Malformations of the polymicrogyria spectrum can be mimicked in rodents through neonatal transcranial focal cortical freeze lesions." | 1.72 | Altered excitatory and inhibitory neocortical circuitry leads to increased convulsive severity after pentylenetetrazol injection in an animal model of schizencephaly, but not of microgyria. ( Adriani Marques, S; Blanco Martinez, AM; Borges Savoldi, LM; Campello Costa Lopes, P; de Souza Aguiar Dos Santos, DM; Dos Santos Heringer, L; Magalhães Portela, D; Martinez Martinez Toledo, AL; Rios Carvalho, J; Rocha Mendonça, H; Teixeira Oliveira, J; Texeira Silva, B, 2022) |
| "Seizures were induced by pentylenetetrazol and maximal electroshock." | 1.72 | Opioidergic and nitrergic systems mediate the anticonvulsant effect of mefloquine and chloroquine on seizures induced by pentylenetetrazol and maximal electroshock in mice. ( Boroujeni, SS; Dehpour, AR; Jafari, RM; Karimi, E; Maleki, A; Mohammadi, P; Sabzevari, O; Shafaroodi, H; Solaimanian, S, 2022) |
| "Epilepsy is often considered to be a progressive neurological disease, and the nature of this progression remains unclear." | 1.72 | Insights into the development of pentylenetetrazole-induced epileptic seizures from dynamic metabolomic changes. ( Cheng, P; Jia, P; Liao, S; Meng, K; Xiao, C; Xu, R; Zhao, X; Zheng, X, 2022) |
| "Epilepsy is a widespread and mainly severe neurological condition portrayed by recurring spontaneous seizures caused by the brain's abnormal electrical activity." | 1.72 | Anti-seizure effect of zinc on PTZ-induced epilepsy in rat model. ( Erbas, O; Erdogan, MA; Kirazlar, M, 2022) |
| "Epilepsy is a neurological disorder caused by abnormally elevated neuronal firing and excitability." | 1.72 | Decreased Spire2 Expression is Involved in Epilepsy. ( Guo, Y; Hao, L; Jing, W; Peng, X; Wang, X; Yang, M; Yang, Y; Zhang, H, 2022) |
| " Using an animal model of chemically-induced epileptic seizures, we tested exercise alone as non-pharmacological therapy, and exercise combined with an anti-inflammatory drug." | 1.72 | Aerobic exercise, alone or combined with an anti-inflammatory drug, reduces the severity of epileptic seizures and levels of central pro-inflammatory cytokines in an animal model of epileptic seizures. ( Barbosa, BB; Coitinho, AS; de Lima Rosa, G; Domingues, AM; Guzzo, EFM; Nunes, SEB; Padilha, RB; Siqueira, IR, 2022) |
| "The risk of seizures is 10-fold higher in patients with Alzheimer's disease than the general population, yet the mechanisms underlying this susceptibility and the effects of these seizures are poorly understood." | 1.72 | The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease. ( Barbour, AJ; Eberwine, G; Gourmaud, S; Irwin, DJ; Jensen, FE; O'Brien, WT; Roberts, N; Stewart, DA; Talos, DM; Vassar, R, 2022) |
| "Their effects on seizure susceptibility and spontaneous epileptic seizures were evaluated with a pentylenetetrazol (PTZ) test in 2 weeks and with continuous video and wireless electroencephalography (EEG) monitoring between 2 and 6 weeks after injury, respectively." | 1.62 | Blocking receptor for advanced glycation end products (RAGE) or toll-like receptor 4 (TLR4) prevents posttraumatic epileptogenesis in mice. ( Chai, Z; Jin, X; Ma, C; Ping, X; Wang, W; White, FA, 2021) |
| "Melatonin has been used in clinical anti-epileptic studies, but its effect on epileptic comorbidities is unknown, and the underlying mechanism needs further investigation." | 1.62 | Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish. ( Gao, D; Jin, M; Li, N; Liu, K; Mou, L; Ren, Q; Sik, A; Zhang, M; Zhang, S, 2021) |
| "First myoclonic jerks decreased while seizure severity and total spike count increased in the PTZ group." | 1.62 | Vortioxetine suppresses epileptiform activity and cognition deficits in a chronic PTZ-induced kindling rat model. ( Taskiran, M; Unal, G, 2021) |
| "Therefore, early cellular response to seizures in the brain includes induction of the Ntrk2, Ntrk3, Ngfr, miRNA-9, and miRNA-29a expression, as well as activation of Bcl-2 and Bax signaling pathways, which may characterize them as important mediators of neuronal adaptation and survival upon induction of the generalized brain activity." | 1.62 | Early Induction of Neurotrophin Receptor and miRNA Genes in Mouse Brain after Pentilenetetrazole-Induced Neuronal Activity. ( Anokhin, KV; Gruzdeva, AM; Ivashkina, OI; Klimovich, PS; Popov, VS; Rubina, KA; Rysenkova, KD; Semina, EV; Shmakova, AA; Tkachuk, VA, 2021) |
| "The latency, frequency and duration of seizures evaluated using EEG recordings from the frontal and parietal cortices of rats showed significant changes demonstrating the inhibition of paroxystic activity." | 1.62 | Anticonvulsant activity of Valeriana edulis roots and valepotriates on the pentylenetetrazole-induced seizures in rats. ( Contreras-Murillo, G; González-Trujano, ME; Hidalgo-Flores, FJ; López-Najera, CA; Magdaleno-Madrigal, VM; Navarrete-Castro, A; Sánchez, CG, 2021) |
| "Epilepsy is a chronic brain disease affecting millions of people worldwide." | 1.62 | Environmental enrichment alters neurobehavioral development following maternal immune activation in mice offspring with epilepsy. ( Mosaferi, B; Najdi, N; Salari, AA; Zeraati, M, 2021) |
| "In various organisms, stress is a seizure-related comorbidity." | 1.62 | Stress increases susceptibility to pentylenetetrazole-induced seizures in adult zebrafish. ( Canzian, J; Franscescon, F; Müller, TE; Rosa, LV; Rosemberg, DB; Souza, TP; Stefanello, FV, 2021) |
| "Seizures are a threat to the host brain and body and can even cause death in epileptic children." | 1.62 | Gut microbiota modulation by both Lactobacillus fermentum MSK 408 and ketogenic diet in a murine model of pentylenetetrazole-induced acute seizure. ( Eor, JY; Kim, SH; Kwak, MJ; Son, YJ; Tan, PL, 2021) |
| "Seizures were evaluated by video-EEG during one hour and scored according to Racine scale." | 1.62 | Effect of Memantine on Pentylenetetrazol-induced Seizures and EEG Profile in Animal Model of Cortical Malformation. ( Cagliari Zenki, K; Calcagnotto, ME; Klippel Zanona, Q; Lazzarotto, G, 2021) |
| "camptopus in acute models of epileptic seizures in Wistar rats." | 1.62 | Anticonvulsant effects of the aqueous and methanol extracts from the stem bark of Psychotria camptopus Verdc. (Rubiacaea) in rats. ( Chouna, R; Dongmo, AK; Fokoua, AR; Kaptué Wuyt, A; Ndjenda, MK; Nguelefack, TB; Nkeng-Efouet, PA; Tatsinkou Bomba, FD, 2021) |
| " Various experimental models have been used to study epilepsy, including that based on acute or chronic administration of Pentylenetetrazol (PTZ)." | 1.62 | Pentylenetetrazol-induced seizures in adult rats are associated with plastic changes to the dendritic spines on hippocampal CA1 pyramidal neurons. ( Flores-Soto, M; González-Burgos, I; Martín-Amaya-Barajas, FL; Orozco-Suárez, S; Romero-Guerrero, C; Tejeda-Martínez, A; Vázquez-Hernández, N, 2021) |
| "Pediatric patients with epilepsy are prone to cognitive impairments during growth and long-term use of most antiepileptic drugs (AED)." | 1.62 | Pharmacological Activity of Pyrazole Derivatives as an Anticonvulsant for Benefit against Epilepsy. ( Gao, M; Qu, K; Wang, X; Zhang, W, 2021) |
| "However, ND with synbiotics seizure reducing effect requires further analysis." | 1.62 | Neuroprotective effect of both synbiotics and ketogenic diet in a pentylenetetrazol-induced acute seizure murine model. ( Eor, JY; Kang, HC; Kim, JH; Kim, JY; Kim, SH; Son, YJ; Youn, SE, 2021) |
| "On the 15th day, the seizure was induced (except the control group) by intraperitoneal injection of PTZ." | 1.62 | Anti-convulsive Effect of Thiamine and Melatonin Combination in Mice: Involvement of Oxidative Stress. ( Dehdashtian, E; Fatemi, I; Hemati, K; Hosseinzadeh, A; Karimi, MY; Mehrzadi, S, 2021) |
| "Epilepsy is a chronic encephalopathy and one of the most common neurological disorders." | 1.62 | Inhibition of Death-associated Protein Kinase 1 protects against Epileptic Seizures in mice. ( Chen, D; Gan, CL; Hu, L; Lan, G; Lee, TH; Liu, H; Mei, Y; Shui, X; Wang, L; Xia, Y; Zhang, T; Zou, Y, 2021) |
| " Curcumin is the principle curcuminoid of Curcuma longa, or colloquially turmeric, and has been experimentally proven to have anti-convulsive properties, but its poor bioavailability has dampened further therapeutic interest." | 1.62 | Identification of curcumin analogues with anti-seizure potential in vivo using chemical and genetic zebrafish larva seizure models. ( Abas, F; Choo, BKM; Faudzi, SMM; Kundap, UP; Samarut, É; Shaikh, MF, 2021) |
| "Unregulated neuro-inflammation mediates seizures in temporal lobe epilepsy (TLE)." | 1.62 | Downregulation of CD40L-CD40 attenuates seizure susceptibility and severity of seizures. ( Anderson, T; Borenstein, R; Howard, K; Major, CK; Musto, AE; Ojeda, A; Pototskiy, E; Sharma, D; Vinokuroff, K, 2021) |
| "The present study aims to evaluate the efficacy of selenium (Se) alone or combined with carbamazepine (CBZ) against the adverse effects induced by the chemoconvulsant pentylenetetrazole (PTZ) in the cortex of adult male rats." | 1.56 | Electrophysiological and Neurochemical Assessment of Selenium Alone or Combined with Carbamazepine in an Animal Model of Epilepsy. ( Aboul Ezz, HS; Ali, MA; Mohammed, HS; Zedan, A, 2020) |
| "Increased behavioral manifestations and seizure severity was observed in the stress group compared with the control group at both ages." | 1.56 | Physical exercise during pregnancy minimizes PTZ-induced behavioral manifestations in prenatally stressed offspring. ( Arida, RM; da Silva, EA; Gutierre, RC; Lopim, GM, 2020) |
| "In India, it is used for the treatment of epilepsy as traditional medicine." | 1.56 | An interaction study of Ocimum sanctum L. and levetiracetam in pentylenetetrazole kindling model of epilepsy. ( Dinda, AK; Kaleekal, T; Katyal, J; Pattnaik, SS; Sarangi, SC, 2020) |
| " The employment of different dosage groups enabled us to characterize the dose range reliably inducing seizures." | 1.56 | Pentylenetetrazole-induced Seizure Susceptibility in the Tau58/4 Transgenic Mouse Model of Tauopathy. ( De Deyn, PP; Valkenburg, F; Van Dam, D; Van Erum, J, 2020) |
| " Despite its pharmacological properties, the poor bioavailability of resveratrol has been an important barrier that hinders its application as an anticonvulsant." | 1.56 | Micronized resveratrol shows promising effects in a seizure model in zebrafish and signalizes an important advance in epilepsy treatment. ( Aguiar, GPS; Almeida, ER; Decui, L; Garbinato, CLL; Mazon, SC; Müller, LG; Oliveira, JV; Schneider, SE; Siebel, AM, 2020) |
| "Epilepsy is a debilitating neurological illness that affects all aspect of an individual life." | 1.56 | Prolonged febrile seizure history exacerbates seizure severity in a pentylenetetrazole rat model of epilepsy. ( Alese, OO; Mabandla, MV; Mkhize, NV; Rakgantsho, C; Zulu, S, 2020) |
| "EPO pretreatment decreased seizure severity and prolonged seizure latency." | 1.56 | Effects of erythropoietin pretreatment on single dose pentylentetrazole-induced seizures in rats. ( Akgün-Dar, K; Kaptan, Z; Kapucu, A; Üzüm, G, 2020) |
| "Here, we hypothesize that Dravet syndrome may be treated by either enhancing Nav1." | 1.56 | NaV1.1 and NaV1.6 selective compounds reduce the behavior phenotype and epileptiform activity in a novel zebrafish model for Dravet Syndrome. ( Bosma, M; Braun, KPJ; Inserra, M; Koeleman, BPC; Rivara, M; Rook, MB; Singh, S; van 't Slot, RH; Verhoeven-Duif, NM; Vetter, I; Volkers, L; Weuring, WJ, 2020) |
| "Pretreatment with daidzin remarkably reduced the severity of epileptogenesis in a dose-dependent manner." | 1.56 | Anti-epileptic activity of daidzin in PTZ-induced mice model by targeting oxidative stress and BDNF/VEGF signaling. ( Kazmi, Z; Khan, A; Khan, S; Malik, S; Seo, EK; Shehzad, A; Zeeshan, S, 2020) |
| "Epileptic seizures constitute a significant comorbidity of Alzheimer's disease (AD), which are recapitulated in transgenic mouse models of amyloidogenesis." | 1.56 | Hyperexcitability and seizures in the THY-Tau22 mouse model of tauopathy. ( Basquin, M; Blum, D; Boison, D; Buée, L; Ferry, B; Gomez-Murcia, V; Laurent, C; Parrot, S; Sandau, U, 2020) |
| "Reversible posterior leukoencephalopathy syndrome (RPLS) is a clinical-imaging syndrome as well as a critical maternal complication." | 1.56 | Contribution of excess inflammation to a possible rat model of eclamptic reversible posterior leukoencephalopathy syndrome induced by lipopolysaccharide and pentylenetetrazol: A preliminary study. ( Chen, D; Fang, X; Liang, Y; Liu, Y; Xie, M; Zhang, W, 2020) |
| "Epilepsy is one of the most common neurological diseases." | 1.56 | COX-2-PGE ( Dong, J; Gan, G; Hu, S; Li, X; Yang, J; Yao, Y; Zhang, A; Zhang, C; Zhengxie, J; Zhu, X, 2020) |
| "New mouse models of epilepsy are needed to better understand the complex genetic architecture of seizures and to identify therapeutics." | 1.56 | Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility. ( Bell, TA; Dalton, KA; Gu, B; Hock, P; Miller, DR; Pan, Y; Pardo-Manuel de Villena, F; Philpot, BD; Shaw, GD; Shorter, JR; Williams, LH, 2020) |
| "Epilepsy is a chronic disease, while epileptogenesis is a latent period where brain will be transformed into an epileptic one." | 1.56 | Integrative analysis of non-targeted lipidomic data and brain structural imaging identifies phosphatidylethanolamine associated with epileptogenesis. ( Chen, L; Gong, M; Kinoshita, M; Lai, W; Li, W; Peng, A; Qiu, X; Yang, L; Zhang, L; Zheng, W, 2020) |
| "Furthermore, PTZ evoked seizure severity was considerably decreased, while latency to clonic-like seizure was increased in adult zebrafish group treated with 100 nM of LY294002." | 1.51 | Anticonvulsant action of a selective phosphatidylinositol-3-kinase inhibitor LY294002 in pentylenetetrazole-mediated convulsions in zebrafish. ( Kumari, S; Mazumder, AG; Singh, D, 2019) |
| "Eclampsia is characterized by high morbidity and mortality wordwide." | 1.51 | Magnesium sulfate attenuates brain edema by lowering AQP4 expression and inhibits glia-mediated neuroinflammation in a rodent model of eclampsia. ( Li, X; Liu, H; Yang, Y, 2019) |
| "The animals were assessed for seizure score, neuronal damage and inflammatory cytokines levels (IL-1β, IL-6 and TNF-α) in hippocampus." | 1.51 | Effect of dimethyl fumarate on neuroinflammation and apoptosis in pentylenetetrazol kindling model in rats. ( Banerjee, D; Bhatia, A; Chakrabarti, A; Kumari, P; Saha, L; Singh, J; Singh, N, 2019) |
| "Epilepsy is a common clinical syndrome characterized by sudden and recurrent attacks and temporary central nervous system dysfunction caused by excessive discharge of neurons in the brain." | 1.51 | Exploratory Cortex Metabolic Profiling Revealed the Sedative Effect of Amber in Pentylenetetrazole-Induced Epilepsy-Like Mice. ( Chen, C; Duan, J; Guo, J; Guo, S; Qian, D; Shang, E; Tang, Z; Yan, H; Zhao, M; Zhu, Y; Zhu, Z, 2019) |
| "In the pentylenetetrazol (PTZ) seizure-susceptibility test, dKO mice had a shorter latency to the first epileptiform spike (p = 0." | 1.51 | Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility. ( Bolkvadze, T; Ekolle Ndode-Ekane, X; Koivisto, H; Kyyriäinen, J; Lipponen, A; Pérez, LO; Pitkänen, A; Tanila, H, 2019) |
| "Thereafter, PTZ seizure threshold was measured in control and treated rats, and different brain regions were analyzed for levels of oxidative stress biomarkers." | 1.51 | Vitamin E modifies high-fat diet-induced reduction of seizure threshold in rats: Role of oxidative stress. ( Al Yacoub, ON; Alomari, MA; Alrabadi, NN; Alzoubi, KH; Banihani, SA; Hasan, ZA; Khabour, OF; Mayyas, FA, 2019) |
| "Febrile seizure is a common neurological disorder observed in neonates." | 1.51 | Protective effects of M8‑B, a TRPM8 antagonist, on febrile‑ and pentylenetetrazol‑induced seizures. ( Moghimi, A; Roohbakhsh, A; Zandi, N; Zaniani, NR, 2019) |
| "Animals were divided into sham, seizure, exercise (EX), co-seizure-induced exercise (Co-SI EX) and Pre-SI EX groups." | 1.51 | The effect of exercise on GABA signaling pathway in the model of chemically induced seizures. ( Barzroodi Pour, M; Bayat, M; Eftekharzadeh, M; Golab, F; Karimzadeh, F; Katebi, M; Soleimani, M, 2019) |
| "However, the latency time to seizure onset was unaltered." | 1.51 | The anticonvulsant and neuroprotective effects of kir2.3 activation in PTZ-induced seizures and the kainic acid model of TLE. ( Hong, Z; Sun, W; Wang, Y; Wu, X; Xu, L; Zhang, L; Zhu, G, 2019) |
| "The susceptibility to seizures was evaluated by seizure frequency and duration." | 1.51 | Chronic exercise buffers the cognitive dysfunction and decreases the susceptibility to seizures in PTZ-treated rats. ( Chen, W; Cui, Y; Lin, XY; Wang, L, 2019) |
| "Epilepsy is a complicated neurological disorder that occurs worldwide and features several kinds of comorbidities in addition to recurrent seizures." | 1.48 | Adenosine A1 Receptors Play an Important Protective Role Against Cognitive Impairment and Long-Term Potentiation Inhibition in a Pentylenetetrazol Mouse Model of Epilepsy. ( Guo, Y; Hu, Q; Kang, H; Lian, L; Liu, X; Xu, F; Zhang, N; Zhou, Q; Zhu, S, 2018) |
| "The proposed animal model of seizures is characterized by SW discharges which remain stable for 2 h." | 1.48 | A New Rat Model of Seizures Suitable for Screening Antiepileptic Electrical Stimulation Therapies. ( Harreby, KR; Jensen, W; Jiao, J; Sevcencu, C, 2018) |
| "Boldine is an aporphine alkaloid which is best known for its antioxidant, anti-inflammatory and cytoprotective characteristics." | 1.48 | Sub-chronic boldine treatment exerts anticonvulsant effects in mice. ( Dastgheib, M; Jamshidzadeh, A; Moezi, L; Pirsalami, F; Yahosseini, S, 2018) |
| "The acute PTZ-induced seizure threshold was also unchanged in mice lacking TIA-1 protein, indicating that this RNA binding protein does not influence the innate seizure threshold." | 1.48 | Maintenance of the Innate Seizure Threshold by Cyclooxygenase-2 is Not Influenced by the Translational Silencer, T-cell Intracellular Antigen-1. ( Gong, Y; Hewett, JA, 2018) |
| "Despite the development of newer anti-seizure medications over the past 50 years, 30-40% of patients with epilepsy remain refractory to treatment." | 1.48 | A novel metabolism-based phenotypic drug discovery platform in zebrafish uncovers HDACs 1 and 3 as a potential combined anti-seizure drug target. ( de la Hoz, CL; Gavrilovici, C; Ibhazehiebo, K; Kaushik, G; Kim, DY; Kurrasch, DM; Ma, SC; Meza Santoscoy, PL; Nath, N; Rehak, R; Rho, JM; Scott, L, 2018) |
| "Although generalized tonic-clonic seizures were reported in a healthy man after taking tadalafil, the influence of tadalafil on seizure susceptibility has not been studied so far." | 1.48 | Effect of Tadalafil on Seizure Threshold and Activity of Antiepileptic Drugs in Three Acute Seizure Tests in Mice. ( Doboszewska, U; Nieoczym, D; Pieróg, M; Socała, K; Szafarz, M; Wlaź, P; Wyska, E, 2018) |
| "Tonic-clonic seizures were induced by an injection of Pentylenetetrazol (80 mg/kg, i." | 1.48 | Anticonvulsive effects of endocannabinoids; an investigation to determine the role of regulatory components of endocannabinoid metabolism in the Pentylenetetrazol induced tonic- clonic seizures. ( Moradi-Chameh, H; Palizvan, MR; Sadegh, M; Zareie, P, 2018) |
| "The overexpression of AZGP1 reduced the seizure severity, prolonged the latency of kindling, and alleviated epileptiform discharges in EEG changes induced by PTZ." | 1.48 | Overexpression of zinc-α2-glycoprotein suppressed seizures and seizure-related neuroflammation in pentylenetetrazol-kindled rats. ( Chen, L; Ding, X; Liu, X; Liu, Y; Mo, L; Tan, X; Wang, T; Wei, X; Wen, Y; Xu, T; Yin, M; Yu, X, 2018) |
| "Seizures affect about 50 million people around the world." | 1.48 | Clarified Açaí ( ( Arrifano, GPF; Carvalho, JCT; Crespo-López, ME; Farina, M; Lichtenstein, MP; Rogez, H; Souza-Monteiro, JR; Suñol, C, 2018) |
| "To assess seizure activity, we employed 2 in vivo mouse models of epilepsy, intravenous (iv) pentylenetetrazol (PTZ) and hippocampal electrical kindling, in the presence or absence of Sema4D treatment." | 1.48 | Semaphorin 4D promotes inhibitory synapse formation and suppresses seizures in vivo. ( Acker, DWM; Kang, M; Paradis, S; Wong, I, 2018) |
| "Epilepsy is a chronic neurological disorder which affects 65 million worldwide population and characterized by recurrent seizure in epileptic patients." | 1.48 | The anti-epileptogenic and cognition enhancing effect of novel 1-[4-(4-benzo [1, 3] dioxol-5-ylmethyl-piperazin-1-yl)-phenyl]-3-phenyl-urea (BPPU) in pentylenetetrazole induced chronic rat model of epilepsy. ( Kumari, S; Mishra, CB; Siraj, F; Tiwari, AK; Tiwari, M; Yadav, R, 2018) |
| "Pentylenetetrazole (PTZ) is a GABA-A receptor antagonist." | 1.48 | Pentylenetetrazole-Induced Kindling Mouse Model. ( Shimada, T; Yamagata, K, 2018) |
| "Thereafter, the PTZ seizure threshold was measured in control and HFD rats." | 1.48 | The effect of high-fat diet on seizure threshold in rats: Role of oxidative stress. ( Al Yacoub, ON; Alrabadi, N; Alzoubi, KH; Azab, MA; Banihani, SA; Hasan, ZA; Khabour, OF; Mayyas, FA, 2018) |
| "BACKGROUND Epilepsy is a complex neurologic disorder with abnormal electrical impulses in the brain." | 1.48 | Modulation of P2X Purinoceptor 3 (P2X3) in Pentylenetetrazole-Induced Kindling Epilepsy in Rats. ( Han, Z; Wang, H; Xia, J; Zhang, Q, 2018) |
| "Head-bobbing convulsions were previously reported to be inducible by pentylenetetrazol (PTZ) in C." | 1.48 | A Caenorhabditis elegans assay of seizure-like activity optimised for identifying antiepileptic drugs and their mechanisms of action. ( Barclay, JW; Burgoyne, RD; Cunliffe, VT; Dodd, S; Grimes, D; Jones, A; Marson, AG; Morgan, A; Sills, GJ; Wong, SQ, 2018) |
| "Seizures are sustained neuronal hyperexcitability in brain that result in loss of consciousness and injury." | 1.48 | Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish. ( Han, L; He, Q; Ji, X; Jin, M; Liu, K; Sheng, W, 2018) |
| "These data suggest that convulsive seizures can be obtained in FPI-treated rats when NSS is used as an inclusion criterion to select rats with severe injury." | 1.48 | Convulsive seizures and EEG spikes after lateral fluid-percussion injury in the rat. ( Kelly, W; MacWilliams, Z; Patterson, D; Poulsen, A; Poulsen, D; Rau, T; Smith, D, 2018) |
| "Cunaniol-induced seizures displayed a cyclic development of electrocorticographic seizures, presenting interictal-like spike and ictal period, which correlates to the behavioral observations and is in line with acute seizures induced by pentylenetetrazole." | 1.48 | Cunaniol-elicited seizures: Behavior characterization and electroencephalographic analyses. ( Barbas, LAL; de Mello, VJ; do Nascimento, JLM; Dos Santos Batista, L; Dos Santos Batista, P; Farias, RAF; Gomes-Leal, W; Hamoy, M; Hutchison, WD; Marcondes, HC; Taylor, JG; Torres, MF, 2018) |
| "Epilepsy is one of the most common neurological disorders and the administration of antiepileptic drugs (AEDs) is the most common treatment." | 1.46 | DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy. ( Li, XM; Ma, XX; Ni, KM; Sun, P; Wei, X; Xu, M; Yang, CH; Yang, CR; Zhang, Y; Zhang, YJ, 2017) |
| "It has been established that febrile seizures and its extended syndromes like generalized epilepsy with febrile seizures (FS) plus (GEFS+) and Dravet syndrome have been associated with mutations especially in SCN1A and GABRG2 genes." | 1.46 | Heat induced temperature dysregulation and seizures in Dravet Syndrome/GEFS+ Gabrg2 ( Kang, JQ; Liu, Z; Macdonald, RL; Warner, TA, 2017) |
| "Recurrent seizures that define epilepsy are often accompanied by psychosocial problems and cognitive deficits with incompletely understood aetiology." | 1.46 | The PTZ kindling mouse model of epilepsy exhibits exploratory drive deficits and aberrant activity amongst VTA dopamine neurons in both familiar and novel space. ( Ahmadi, M; Dufour, JP; Mirnajafi-Zadeh, J; Saab, BJ; Seifritz, E, 2017) |
| "In the PTZ-induced seizures test, VRB showed anticonvulsant activity at doses of 200 mg/kg i." | 1.46 | Anticonvulsive activity of (1S)-(-)-verbenone involving RNA expression of BDNF, COX-2, and c-fos. ( Braga, RM; da Fonsêca, DV; de Almeida, RN; de Farias, IEV; de Luna Freire Pessôa, H; de Melo, CGF; de Sousa, DP; do Amaral, IPG; Filho, MRDC; Lima, EM; Salgado, PRR, 2017) |
| "Epilepsy is a chronic neurological condition, with over 30% of cases unresponsive to treatment." | 1.46 | Automated analysis of brain activity for seizure detection in zebrafish models of epilepsy. ( Copmans, D; de Witte, PAM; Hunyadi, B; Siekierska, A; Sourbron, J, 2017) |
| "for 15 days." | 1.46 | Ferulic Acid Supplementation for Management of Depression in Epilepsy. ( Goel, RK; Kaur, T; Singh, T, 2017) |
| "Epilepsy is one of the most common neurologic disorders worldwide with no distinguishable cause in 60% of patients." | 1.46 | Toxoplasmosis accelerates acquisition of epilepsy in rats undergoing chemical kindling. ( Asgari, T; Babaie, J; Choopani, S; Gharagozli, K; Golkar, M; Sayyah, M, 2017) |
| "Most antidepressants lower seizure threshold, which might be due to the modulation of serotonergic neurotransmission." | 1.46 | HBK-14 and HBK-15, triple 5-HT ( Gryboś, A; Nieoczym, D; Pieróg, M; Pytka, K; Rapacz, A; Siwek, A; Socała, K; Waszkielewicz, A; Wlaź, P, 2017) |
| " Serum levels of valproate were estimated using HPLC for pharmacokinetic study." | 1.46 | Pharmacokinetic and pharmacodynamic interaction of hydroalcoholic extract of Ocimum sanctum with valproate. ( Gupta, YK; Joshi, D; Kaleekal, T; Kumar, R; Sarangi, SC, 2017) |
| "Alzheimer's disease is a common age associated neurodegenerative disorder associated with an elevated risk of seizures that may be fundamentally connected to cognitive dysfunction." | 1.46 | Seizure susceptibility in the APP/PS1 mouse model of Alzheimer's disease and relationship with amyloid β plaques. ( Nuñez, A; Reyes-Marin, KE, 2017) |
| "The median seizure stage, latency onset of first stage 4/5 seizures, and incidence of convulsing animals were recorded." | 1.46 | Octreotide ameliorates inflammation and apoptosis in acute and kindled murine PTZ paradigms. ( Al-Shorbagy, MY; Nassar, NN, 2017) |
| "Epilepsy is a common brain disorder characterized by the occurrence of recurring, unprovoked seizures." | 1.46 | EGAR, A Food Protein-Derived Tetrapeptide, Reduces Seizure Activity in Pentylenetetrazole-Induced Epilepsy Models Through α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionate Receptors. ( Cai, M; Cai, S; Chen, L; Duan, S; Gu, H; Lin, R; Ling, C; Lu, J; Pan, X; Wang, Y; Zhu, H, 2017) |
| "Crocin treatment at 5, 10 and 20 mg/kg p." | 1.46 | Crocin Attenuates Kindling Development and Associated Cognitive Impairments in Mice via Inhibiting Reactive Oxygen Species-Mediated NF-κB Activation. ( Mazumder, AG; Patial, V; Sharma, P; Singh, D, 2017) |
| "Luteolin was investigated on the course of kindling development and oxidative stress markers [reduced glutathione (GSH) and malondialdehyde (MDA)] in kindled mice." | 1.46 | Assessment of luteolin isolated from Eclipta alba leaves in animal models of epilepsy. ( Jain, P; Patil, A; Sancheti, J; Sathaye, S; Somani, G; Tambe, R, 2017) |
| "Linalool is a major constituent of the essential oil of several plant species and possesses several biological activities." | 1.46 | The effects of linalool on the excitability of central neurons of snail Caucasotachea atrolabiata. ( Bazleh, S; Janahmadi, M; Vatanparast, J, 2017) |
| "Depression was evaluated in all experimental groups using the tail suspension and sucrose preference test on days 1, 5, 10 and 15, 2 h after pentylenetetrazole challenge." | 1.46 | Adjuvant quercetin therapy for combined treatment of epilepsy and comorbid depression. ( Goel, RK; Kaur, T; Singh, T, 2017) |
| "Lafora disease is caused by loss-of-function mutations in either the EPM2A or EPM2B genes." | 1.46 | Sodium selenate treatment improves symptoms and seizure susceptibility in a malin-deficient mouse model of Lafora disease. ( Sánchez, MP; Sánchez-Elexpuru, G; Serratosa, JM, 2017) |
| "Understanding how the brain responds to seizures is important for development of new treatment strategies for epilepsy, a neurological condition characterized by recurrent and unprovoked seizures." | 1.46 | Cellular responses to recurrent pentylenetetrazole-induced seizures in the adult zebrafish brain. ( Beattie, CE; Berberoglu, MA; Duy, PQ; Hall, CW, 2017) |
| "Epilepsy is a kind of neurogenic diseases with high prevalence and characterized by seizure, brain paradoxical discharge and convulsion in spontaneous, transient, recurrent and uncontrolled manner." | 1.43 | [Establish and use of an epilepsy model in larval zebrafish]. ( Song, DQ; Tang, S; Zhang, JP; Zheng, YM, 2016) |
| "The different effects of quercetin on seizure threshold may occur through several mechanisms." | 1.43 | Comparison between the effects of quercetin on seizure threshold in acute and chronic seizure models. ( Abbasi, E; Hajiali, F; Mohseni, F; Nassiri-Asl, M; Taghiloo, M; Yousefi, F, 2016) |
| "Treatment with phenytoin per se and along with the flavonoid rich fraction showed significant reduction in seizure severity score as compared to vehicle control." | 1.43 | Protective effect on phenytoin-induced cognition deficit in pentylenetetrazol kindled mice: A repertoire of Glycyrrhiza glabra flavonoid antioxidants. ( Goel, RK; Singh, D; Singh, P, 2016) |
| "Traumatic brain injury was exerted to parieto-temporal cortex of anaesthetised rats by controlled cortical impact (CCI, 5 mm round tip, 4." | 1.43 | Traumatic brain injury accelerates kindling epileptogenesis in rats. ( Amiri, Z; Choopani, S; Eslami, M; Etemadi, F; Ghanbari, E; Hadjighassem, M; Sayyah, M; Soleimani, M, 2016) |
| "Using the maximal electroshock seizure (MES) as a model of tonic-clonic generalized seizures, we report that mice treated with TTA-A2 (0." | 1.43 | Blockade of T-type calcium channels prevents tonic-clonic seizures in a maximal electroshock seizure model. ( Chemin, J; Forichon, L; Françon, D; Gangarossa, G; Lerat, B; Lerner-Natoli, M; Lory, P; Sakkaki, S; Valjent, E, 2016) |
| "Taken together, although the seizure threshold is reduced in naive Spry2/4(+/-) mice, neurodegeneration and GCD is mitigated following KA induced hippocampal lesions, identifying Spry proteins as possible pharmacological targets in brain injuries resulting in neurodegeneration." | 1.43 | Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage. ( Agostinho, AS; Burtscher, J; Fogli, B; Hausott, B; Klimaschewski, L; Marvaldi, L; Schwarzer, C; Thongrong, S; Zangrandi, L, 2016) |
| "Adequate control of seizures remains an unmet need in epilepsy." | 1.43 | Anticonvulsant activity, crystal structures, and preliminary safety evaluation of N-trans-cinnamoyl derivatives of selected (un)modified aminoalkanols. ( Gunia-Krzyżak, A; Koczurkiewicz, P; Marona, H; Nitek, W; Pękala, E; Szkaradek, N; Słoczyńska, K; Waszkielewicz, AM; Żelaszczyk, D; Żesławska, E, 2016) |
| "Epilepsy or seizure disorder is among the least understood chronic medical conditions affecting over 65 million people worldwide." | 1.43 | Disruption of polycystin-L causes hippocampal and thalamocortical hyperexcitability. ( Basora, N; Contreras, D; Du, Y; Harvey, M; Luo, C; Schreiber, TH; Su, X; Wu, M; Yao, G; Zhou, J, 2016) |
| "Chloroquine has long been used for the treatment of malaria and rheumatological disorders." | 1.43 | Possible involvement of nitrergic and opioidergic systems in the modulatory effect of acute chloroquine treatment on pentylenetetrazol induced convulsions in mice. ( Abkhoo, A; Amiri, S; Boojar, MM; Dehpour, AR; Delazar, S; Hassanipour, M; Ostadhadi, S; Rahimi, N; Shirzadian, A, 2016) |
| "The threshold for seizure induction with progressive intravenous infusion of pentylenetrazole (PTZ) was evaluated in anesthetized Wistar rats after a ten-day oral administration of BD-AcAc2 (gavage)." | 1.43 | Different calorie restriction treatments have similar anti-seizure efficacy. ( Arnold, P; Coppola, G; D'Agostino, D; Monda, M; Pilla, R; Viggiano, A; Zeppa, P, 2016) |
| "During ongoing SW seizures, SCS was conducted at 30, 80, 130, and 180 Hz and VNS at 10, 30, 80, 130, and 180 Hz." | 1.43 | The Influence of Vagus Nerve and Spinal Cord Stimulation on the Ictal Fast Ripple Activity in a Spike-and-Wave Rat Model of Seizures. ( Harreby, KR; Jensen, W; Jiao, J; Sevcencu, C; Yang, X, 2016) |
| "Spontaneous seizures were not detected more often in APParc mice than in their wild-type control mice." | 1.43 | Increased Epileptiform EEG Activity and Decreased Seizure Threshold in Arctic APP Transgenic Mouse Model of Alzheimer's Disease. ( Graff, C; Gurevicius, K; Miszczuk, D; Pitkänen, A; Rönnbäck, A; Tanila, H; Winblad, B; Ziyatdinova, S, 2016) |
| "In this study, three seizure models, including intravenous pentylenetetrazole (PTZ), intraperitoneal PTZ and electroshock, were examined in mice." | 1.43 | The interaction between morphine and propranolol in chemical and electrical seizure models of mice. ( Fakhrzad, A; Khosravani, E; Moezi, L; Shafaroodi, H, 2016) |
| "BPPU also successfully inhibited seizures induced by 3-mercaptopropionic acid (3-MPA) and thiosemicarbazide (TSC) in mice thus, suggested that BPPU might influence GABA-ergic neurotransmission in the brain." | 1.43 | Pharmacological evaluation of novel 1-[4-(4-benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-phenyl]-3-phenyl-urea as potent anticonvulsant and antidepressant agent. ( Kumari, S; Mishra, CB; Tiwari, M, 2016) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 1.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "Vigabatrin is a clinically approved anti-seizure drug, which acts by increasing brain GABA levels by irreversibly inhibiting GABA-aminotransferase (GABA-T)." | 1.43 | Continuous bilateral infusion of vigabatrin into the subthalamic nucleus: Effects on seizure threshold and GABA metabolism in two rat models. ( Gernert, M; Gey, L; Löscher, W, 2016) |
| "Epilepsy is a common neurological disease characterized by periodic seizures." | 1.43 | Prediction of seizure incidence probability in PTZ model of kindling through spatial learning ability in male and female rats. ( Aghaei, Z; Haeri, NA; Palizvan, MR; Rafiei, M; Sadegh, M, 2016) |
| "Neonatal or early-life seizures (ELS) are often associated with life-long neurophysiological, cognitive and behavioral deficits, but the underlying mechanisms contributing to these deficits remain poorly understood." | 1.43 | Neonatal seizures induced by pentylenetetrazol or kainic acid disrupt primary cilia growth on developing mouse cortical neurons. ( Atkinson, EW; Coleman, JE; Hoang-Minh, LB; Le, MM; Parker, AK; Sarkisian, MR; Semple-Rowland, S; Smith, TS; Ugartemendia, G, 2016) |
| "The Pentylenetetrazole-induced seizure was used as a standard convulsion model in this study." | 1.43 | Oxytocin is involved in the proconvulsant effects of Sildenafil: Possible role of CREB. ( Dehpour, AR; Ejtemaei Mehr, S; Fakhfouri, G; Khodagholi, F; Khoshneviszadeh, M; Payandemehr, B; Rahimian, R, 2016) |
| "Racine convulsion scores, first myoclonic jerk time, spike percentages, and antioxidant status were evaluated in the groups." | 1.43 | Inhibitor effect of paricalcitol in rat model of pentylenetetrazol-induced seizures. ( Çavuşoğlu, T; Çetin, EÖ; Çınar, BP; Erbaş, O; Solmaz, V; Sur, HY; Uyanıkgil, Y, 2016) |
| "Seizures were recorded inside the open field apparatus for an average of 10min." | 1.43 | Nicotinic and muscarinic cholinergic receptors are recruited by acetylcholine-mediated neurotransmission within the locus coeruleus during the organisation of post-ictal antinociception. ( Biagioni, AF; Coimbra, NC; de Oliveira, R; de Oliveira, RC; Dos Anjos-Garcia, T; Falconi-Sobrinho, LL, 2016) |
| "During this time, the occurrence of seizures and death was recorded." | 1.43 | Structure-activity relationship for the anticonvulsant effects of organic solvents. ( Cruz, SL; Gauthereau-Torres, MY; Rivera-García, MT, 2016) |
| "Behavioral scoring was used to access seizure." | 1.43 | Anticonvulsant and neuroprotective effects of apelin-13 on pentylenetetrazole-induced seizures in male rats. ( Asadi-Shekaari, M; Esmaeili-Mahani, S; Kalantaripour, TP; Pasban-Aliabadi, H; Sheibani, V, 2016) |
| "Epilepsy is a serious brain disorder with diverse seizure types and epileptic syndromes." | 1.43 | AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets. ( Chen, W; Gao, J; Li, XH; Li, YS; Lin, XY, 2016) |
| "A prominent, seizure intensity-dependent increase of Nav1." | 1.43 | Remarkable alterations of Nav1.6 in reactive astrogliosis during epileptogenesis. ( Ji, Y; Jiang, N; Jin, J; Lin, W; Wang, Z; Wu, H; Zhao, Y; Zhu, H, 2016) |
| "The enhanced seizure susceptibility of the NaV1." | 1.42 | 'Neonatal' Nav1.2 reduces neuronal excitability and affects seizure susceptibility and behaviour. ( Aumann, TD; Churilov, L; Featherby, TJ; Gazina, EV; Hammond, VE; Kim, TH; Leaw, BT; Petrou, S; Reid, CA; Richards, KL; Wimmer, VC, 2015) |
| "Diazepam was used as reference anticonvulsant drug." | 1.42 | Anticonvulsant activity of the ethanolic extract of Punica granatum L. seed. ( FallahHuseini, H; Ghaznavi, H; Gholamine, B; Hosseinzadeh, A; Mehrzadi, S; Sadr, S; Shahbazi, A, 2015) |
| "However, preclinical seizure experiments need to be conducted in awake animals with images reconstructed and displayed in real-time." | 1.42 | Towards real-time detection of seizures in awake rats with GPU-accelerated diffuse optical tomography. ( Carney, PR; Jiang, H; Zhang, T; Zhou, J, 2015) |
| "Pretreatment with pioglitazone, as a PPARγ agonist, potentiated the anticonvulsant effects of WIN, while PPARγ antagonist inhibited these anticonvulsant effects partially." | 1.42 | Involvement of PPAR receptors in the anticonvulsant effects of a cannabinoid agonist, WIN 55,212-2. ( Aghaei, HN; Dehpour, AR; Ebrahimi, A; Gholizadeh, R; Gooshe, M; Mousavizadeh, K; Payandemehr, B; Rahimian, R; Varastehmoradi, B, 2015) |
| "PTZ-induced generalized tonic-clonic seizures were suppressed in 18- and 25-day-old rats by 10 and 20mg/kg doses of IEM1460." | 1.42 | An antagonist of calcium permeable AMPA receptors, IEM1460: Anticonvulsant action in immature rats? ( Mareš, P; Szczurowska, E, 2015) |
| "In contrast, seizures between P20 and P30 did not result in cerebral atrophy or significant imaging abnormalities in the hippocampus or white matter, but irreversibly decreased PPI in the DG compared to normal adult controls." | 1.42 | Age-dependent long-term structural and functional effects of early-life seizures: evidence for a hippocampal critical period influencing plasticity in adulthood. ( Hutchinson, E; Meyerand, ME; Sayin, U; Sutula, T, 2015) |
| "PTZ-kindled mice showed high seizure activity, hippocampal neuronal loss, and expression of growth-associated phosphoprotein (GAP-43) compared with saline-treated mice." | 1.42 | Fluvoxamine alleviates seizure activity and downregulates hippocampal GAP-43 expression in pentylenetetrazole-kindled mice: role of 5-HT3 receptors. ( Alhaj, MW; Moustafa, YM; Zaitone, SA, 2015) |
| "Seizures are a known co-occurring symptom of Alzheimer's disease, and they can accelerate cognitive and neuropathological dysfunction." | 1.42 | Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's disease. ( Harrison, FE; Kang, JQ; Kennard, JA; Warner, TA, 2015) |
| "Pentylenetetrazole-induced seizures, in contrast, were not able to change Homer1a mRNA expression." | 1.42 | Maximal electroshock-induced seizures are able to induce Homer1a mRNA expression but not pentylenetetrazole-induced seizures. ( Blanco, MM; Cavarsan, CF; Matsuo, A; Mello, LE, 2015) |
| "Constipation is a common gastrointestinal disorder characterized by symptoms such as straining, hard stool, and infrequent defecation." | 1.42 | Constipation enhances the propensity to seizure in pentylenetetrazole-induced seizure models of mice. ( Inaloo, S; Moezi, L; Pirsalami, F, 2015) |
| "In two chemically induced seizure models, mice with reduced Homerb/c protein had less severe seizures than control mice." | 1.42 | Down-regulation of Homer1b/c protects against chemically induced seizures through inhibition of mTOR signaling. ( Cao, L; Di, ZL; Jiang, Y; Lei, H; Tian, Y; Zhang, GJ, 2015) |
| "Observed adverse effects differed between CsA treatment regimens and included reversible diarrhea, lowered body temperature, and tremor, the latter two of which were also induced by vehicle injections containing ethanol and/or polyethoxylated castor oil." | 1.42 | Different preparations, doses, and treatment regimens of cyclosporine A cause adverse effects but no robust changes in seizure thresholds in rats. ( Elger, DA; Gernert, M; Gey, L; Handreck, A; Mall, EM, 2015) |
| "Modafinil, is a wake-promoting drug approved by Food and Drugs Administration (FDA) for narcolepsy and sleep-apnoe syndrome." | 1.42 | Effects of modafinil on pentylenetetrazol-induced convulsive epilepsy. ( Aydin, D; Ekici, F; Ozsoy, S, 2015) |
| "The latency time and tonic—clonic seizure time were registered." | 1.42 | Vitis labrusca leaf extract prevents pentylenetetrazol-induced oxidative damage but not seizures in rats. ( Coitinho, AS; da Costa, BM; Dani, C; Dos Santos, MT; Fank, B; Hackmann, CL; Salvador, M, 2015) |
| "The threshold for seizure induction with progressive intravenous infusion of pentylenetrazole (PTZ) was evaluated in anesthetized Wistar rats two hours after a single 1 ml intragastric administration of BD-AcAc2 (i." | 1.42 | Anticonvulsant properties of an oral ketone ester in a pentylenetetrazole-model of seizure. ( Arnold, P; Coppola, G; D'Agostino, D; Monda, M; Pilla, R; Viggiano, A, 2015) |
| "Because oxidative stress and seizures are intimately linked, this study investigated the potential neuroprotective and anticonvulsant effects of commercial clarified açai juice (EO)." | 1.42 | Anticonvulsant properties of Euterpe oleracea in mice. ( Arrifano, GP; Costa-Malaquias, A; Crespo-López, ME; da Silva, RF; de Oliveira, DL; do Nascimento, JL; Hamoy, M; Mendonça, JR; Monteiro, WS; Paraense, RS; Rogez, H; Santana-Coelho, D; Souza-Monteiro, JR, 2015) |
| " Chronic administration of PTZ at 40mg/kg resulted in kindling seizure development." | 1.42 | Decreased expression of hippocampal Na⁺/Ca²⁺ exchanger isoform-1 by pentylenetetrazole kindling in mice. ( Ago, Y; Hasebe, S; Hashimoto, H; Inoue, A; Kawanai, T; Matsuda, T; Ooi, Y; Takuma, K; Taruta, A; Watanabe, R, 2015) |
| "We found that the increased seizure susceptibility in the TSP1 knockout (KO) mice was not due to a compensatory increase in TSP2 mRNA as TSP1/2 KO mice were sensitive to PTZ, similar to the TSP1 KO mice." | 1.42 | Increased sensitivity to kindling in mice lacking TSP1. ( Mendus, D; Mustapha, M; Porter, BE; Rankin-Gee, EK, 2015) |
| "Sulforaphane was anticonvulsant in two acute mouse models of epilepsy and protected mice against pilocarpine-induced status epilepticus (SE)." | 1.42 | Sulforaphane is anticonvulsant and improves mitochondrial function. ( Borges, K; Carrasco-Pozo, C; Tan, KN, 2015) |
| "Latency to induce seizure, seizure stages and latency and duration of fifth stage of seizure was recorded for each animal." | 1.42 | Palmitoylethanolamide attenuates PTZ-induced seizures through CB1 and CB2 receptors. ( Aghaei, I; Babaei, P; Khakpour-Taleghani, B; Motamedi, F; Naderi, N; Rostampour, M; Shabani, M, 2015) |
| "Seizures were assessed by video observation of each animal and the electroencephalogram by an automated seizure detection programme." | 1.42 | Epileptogenic effects of NMDAR antibodies in a passive transfer mouse model. ( Bartram, J; Hashemi, K; Lang, B; Stasiak, L; Upton, AL; Vincent, A; Wright, S, 2015) |
| "Increased frequency of the experimental febrile seizures facilitated PTZ-induced generalized clonic seizures." | 1.40 | Role of TRPV1 in susceptibility to PTZ-induced seizure following repeated hyperthermia challenges in neonatal mice. ( He, XH; Kong, WL; Li, JX; Liu, YL; Min, JW; Peng, BW, 2014) |
| "Epilepsy is a debilitating disease affecting 1-2% of the world's population." | 1.40 | Novel Vitamin K analogs suppress seizures in zebrafish and mouse models of epilepsy. ( Bestman, JE; Chan, SS; Chou, CJ; Inks, ES; Josey, BJ; Rahn, JJ; Rogers, CE; Stackley, KD, 2014) |
| "Latency and probability of PTZ-induced seizures were shorter and higher respectively, in hyperthermia-treated animals compared to controls." | 1.40 | Cognitive performance and convulsion risk after experimentally-induced febrile-seizures in rat. ( Abdeen, Z; Al Shawaaf, F; Al-Ansari, S; Alsaffar, Y; Hassan, Z; Kamal, A; Mandeel, M; Rajab, E, 2014) |
| "Hydrogen sulfide (H2 S) is a gas transmitter that may mediate cerebral ischemic injury." | 1.40 | Aggravation of seizure-like events by hydrogen sulfide: involvement of multiple targets that control neuronal excitability. ( Chen, JG; Guan, XL; He, JG; Hu, ZL; Luo, Y; Wang, F; Wu, PF; Xiao, W; Zhang, JT; Zhou, J, 2014) |
| "Eclampsia is a poorly understood but potentially fatal complication of pregnancy." | 1.40 | Decreased seizure threshold in an eclampsia-like model induced in pregnant rats with lipopolysaccharide and pentylenetetrazol treatments. ( Brennecke, SP; Di, X; Hu, B; Huang, Q; Liu, H; Liu, L, 2014) |
| "Thalidomide is an old glutamic acid derivative which was initially used as a sedative medication but withdrawn from the market due to the high incidence of teratogenicity." | 1.40 | Nitric oxide mediates the anticonvulsant effects of thalidomide on pentylenetetrazole-induced clonic seizures in mice. ( Ahmadi-Dastgerdi, M; Amanlou, M; Aminizade, M; Bahremand, A; Berijani, S; Dehpour, AR; Dianati, V; Gholizadeh, R; Gooshe, M; Payandemehr, B; Rahimian, R; Sarreshte-Dari, A, 2014) |
| "Although epilepsy is a common neurological disorder, its mechanism(s) are still not completely understood." | 1.40 | Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models. ( Chen, L; Chen, Y; Jiang, G; Li, J; Li, Z; Wang, X; Wang, Z, 2014) |
| " Although monoamine oxidase activity remained unaltered by oleanolic acid, chronic administration of oleanolic acid augmented hippocampal BDNF level." | 1.40 | Plurality of anxiety and depression alteration mechanism by oleanolic acid. ( Costa, EA; Da Rocha, FF; Fajemiroye, JO; Florentino, IF; Galdino, PM; Ghedini, PC; Polepally, PR; Zjawiony, JK, 2014) |
| "The maximal electroshock-induced seizure (MES) and pentetrazole (PTZ)-induced seizure models in mice were performed." | 1.40 | Evaluation of anticonvulsant activity of novel pyrrolidin-2-one derivatives. ( Bednarski, M; Dudek, M; Filipek, B; Kulig, K; Kusak, A; Malawska, B; Nowak, G; Sapa, J; Zygmunt, M, 2014) |
| "Muscimol was administered in doses from 0." | 1.40 | Anticonvulsant and behavioral effects of muscimol in immature rats. ( Mareš, P; Mikulecká, A; Tichá, K, 2014) |
| "torvum leaves is used to treat epileptic seizures." | 1.40 | Zebrafish bioassay-guided microfractionation identifies anticonvulsant steroid glycosides from the Philippine medicinal plant Solanum torvum. ( Bock, M; Buenafe, OE; Challal, S; Crawford, AD; Dayrit, FM; de Witte, PA; Esguerra, CV; Harvey, AL; Kloeti, W; Lerche, H; Maljevic, S; Marcourt, L; Queiroz, EF; Wolfender, JL, 2014) |
| "Here, we hypothesized severe preeclampsia is a state of increased seizure susceptibility due to blood-brain barrier (BBB) disruption and neuroinflammation that lowers seizure threshold." | 1.40 | Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia. ( Chan, SL; Cipolla, MJ; Johnson, AC; LaMarca, B; Moseley, J; Nagle, KJ; Tremble, SM, 2014) |
| "Perinatal stroke is a common cerebrovascular disorder affecting 1 in every 4000 births; typically associated with epilepsy." | 1.39 | Increased susceptibility to pentetrazol-induced seizures in developing rats after cortical photothrombotic ischemic stroke at P7. ( Brima, T; Mareš, P; Otáhal, J, 2013) |
| "Pentylenetetrazole effectiveness was dependent on the time of treatment; cognitive performance improved after treatment during the light (inactive) phase, but not during the dark (active) phase." | 1.39 | Short-term treatment with the GABAA receptor antagonist pentylenetetrazole produces a sustained pro-cognitive benefit in a mouse model of Down's syndrome. ( Blank, M; Buckmaster, P; Chuluun, B; Colas, D; Garner, CC; Heller, HC; Warrier, D; Wetmore, DZ, 2013) |
| "In the PTZ-induced seizure model, i." | 1.39 | The role of potassium BK channels in anticonvulsant effect of cannabidiol in pentylenetetrazole and maximal electroshock models of seizure in mice. ( Ahmad-Molaei, L; Motamedi, F; Naderi, N; Shirazi-zand, Z, 2013) |
| "Malondialdehyde (MDA) levels were significantly increased in the quercetin groups compared to the PTZ group in the hippocampus and cerebral cortex following PTZ kindling." | 1.39 | Effects of quercetin on oxidative stress and memory retrieval in kindled rats. ( Abbasi, E; Bazahang, P; Haghighi, MR; Lotfizadeh, M; Moghbelinejad, S; Nassiri-Asl, M; Yonesi, F, 2013) |
| " Luteolin did not exhibit any consistent anti- or pro-convulsant actions after single dosing in the 6 Hz (0." | 1.39 | Anticonvulsant screening of luteolin in four mouse seizure models. ( Borges, K; Shaikh, MF; Tan, KN, 2013) |
| "Diazepam-induced sleep was used for the evaluation of the sedative properties." | 1.39 | The anticonvulsant and sedative effects of Gladiolus dalenii extracts in mice. ( Moto, FC; Ngah, E; Ngo Bum, E; Ngoupaye, GT; Rakotonirina, A; Rakotonirina, SV; Taiwe, GS; Talla, E, 2013) |
| "Hypericum (H." | 1.39 | Anticonvulsant activity of Hypericum scabrum L.; possible mechanism involved. ( Ahangar, N; Ebrahimzadeh, MA; Nabavi, SF; Nabavi, SM, 2013) |
| "In two chemically induced seizure models, mice with reduced tau protein had less severe seizures than control mice." | 1.39 | Antisense reduction of tau in adult mice protects against seizures. ( Bennett, CF; Chen, G; Cirrito, JR; DeVos, SL; Goncharoff, DK; Holtzman, DM; Kebodeaux, CS; Maloney, SE; Miller, TM; Rigo, F; Schuler, DR; Stewart, FR; Wozniak, DF; Yamada, K, 2013) |
| "Handling-evoked and spontaneous convulsive seizures were observed in many BoNT/B-treated animals but not in vehicle-treated controls." | 1.39 | Proconvulsant actions of intrahippocampal botulinum neurotoxin B in the rat. ( Bröer, S; Gernert, M; Rogawski, MA; Zolkowska, D, 2013) |
| "In rodent seizure models, tanshinone IIA showed anticonvulsive activity in the mouse 6-Hz psychomotor seizure test in a biphasic manner and modified seizure thresholds in a complex manner for the mouse i." | 1.39 | Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models. ( Buenafe, OE; Crawford, AD; De Borggraeve, W; de Witte, P; Esguerra, CV; Huang, H; Luyten, W; Maes, J; Orellana-Paucar, A; Ying, X, 2013) |
| " Chronic administration of a subconvulsive dose of PTZ resulted in an increase in convulsive activity culminating in generalized clonic-tonic seizures, as revealed by a progressive increase in seizure score as well as alteration in antioxidant enzyme levels (lipid peroxidation, nitrite, glutathione, super oxide dismutase, and catalase) and mitochondrial complex (I, II, and IV) activities, whereas chronic treatment with hesperidin (200 mg/kg) significantly attenuated these behavioral, biochemical, and mitochondrial alterations." | 1.39 | Possible nitric oxide mechanism in the protective effect of hesperidin against pentylenetetrazole (PTZ)-induced kindling and associated cognitive dysfunction in mice. ( Kumar, A; Lalitha, S; Mishra, J, 2013) |
| "Status epilepticus was induced on the first day of experiment." | 1.39 | Caffeic acid phenethyl ester prevents apoptotic cell death in the developing rat brain after pentylenetetrazole-induced status epilepticus. ( Bayram, E; Karakaya, P; Kurul, SH; Özbal, S; Topçu, Y; Tuğyan, K; Yilmaz, O; Yiş, U, 2013) |
| "FTA significantly increased the seizure latency and decreased the mortality in PTZ-treated mice." | 1.39 | Anticonvulsant effects of Fuzi total alkaloid on pentylenetetrazole-induced seizure in mice. ( Cui, R; Li, B; Li, Y; Liu, L; Song, Y; Tang, F; Wang, L; Wang, Y; Zhao, J; Zhou, Y, 2013) |
| "Caffeine treatment at a daily dose of 10 and/or 20 mg/kg, sc was executed during postnatal days 7-11." | 1.39 | Different effects of postnatal caffeine treatment on two pentylenetetrazole-induced seizure models persist into adulthood. ( Kubová, H; Mareš, P; Tchekalarova, JD, 2013) |
| "Cardiac arrhythmias are a proposed cause for some cases of SUDEP, yet the susceptibility and potential mechanism of arrhythmogenesis in Dravet syndrome remain unknown." | 1.39 | Altered cardiac electrophysiology and SUDEP in a model of Dravet syndrome. ( Auerbach, DS; Clawson, BC; Isom, LL; Jones, J; Lenk, GM; Meisler, MH; Offord, J; Ogiwara, I; Parent, JM; Yamakawa, K, 2013) |
| "Epilepsy is one of the most common neurological disorders, characterized by recurrent seizures, which may increase the content of reactive oxygen and nitrogen species." | 1.39 | Effects of single-dose neuropeptide Y on levels of hippocampal BDNF, MDA, GSH, and NO in a rat model of pentylenetetrazole-induced epileptic seizure. ( Kir, HM; Kuskay, S; Musul, M; Oztaş, B; Sahin, D, 2013) |
| "Our findings indicated that PTZ-induced seizure showed not only decrease in GABABR expression but also cause neuronal apoptosis in the developing rat brain." | 1.39 | Decreased GABABR expression and increased neuronal cell death in developing rat brain after PTZ-induced seizure. ( Al-Qahtani, MH; Ansari, SA; Bibi, F; Karim, S; Kim, MO; Naseer, MI; Ullah, I; Ullah, N, 2013) |
| "Vagus nerve stimulation prevents seizures by continuously activating noradrenergic projections from the brainstem to the cortex." | 1.39 | Closed-loop neural stimulation for pentylenetetrazole-induced seizures in zebrafish. ( Beattie, CE; Hall, CW; Pineda, R, 2013) |
| "In the remaining animals that exhibited seizures, KB-R7943 (3 mg/kg; p." | 1.39 | Probing the role of the sodium/calcium exchanger in pentylenetetrazole-induced generalized seizures in rats. ( N'Gouemo, P, 2013) |
| " The mean dosage to induce seizure in the exposed and control group was 54." | 1.39 | Effects of extremely low frequency electromagnetic field (50 Hz) on pentylenetetrazol-induced seizures in mice. ( Fadakar, K; Farzampour, S; Saba, V, 2013) |
| "We examined the seizure susceptibility of these mice to determine if the presence (BXD29-Trl4(lps-2J)/J) or absence (C57BL/10J) of p-ACC, in strains with MCD, confers a differential response to chemi-convulsive treatment." | 1.39 | Differential seizure response in two models of cortical heterotopia. ( Gabel, LA; Ibanez, N; Manglani, M; Ramos, RL; Roberts, J; Rosen, GD, 2013) |
| "In the animal seizure models tested, the anticonvulsant profile of indazole most resembled that of gabapentin and somewhat resembled those of the AMPA/kainate antagonist NBQX and the sodium channel inhibitor phenytoin, but differed from that of benzodiazepine." | 1.39 | Anticonvulsant action of indazole. ( Aoyama, K; Kikuchi-Utsumi, K; Matsumura, N; Nakaki, T; Sakamaki, K; Watabe, M, 2013) |
| "Latency for the first seizure, tonic-clonic and generalized seizures time, frequency of seizures and mortality induced by PTZ were recorded." | 1.39 | Anticonvulsant, neuroprotective and behavioral effects of organic and conventional yerba mate (Ilex paraguariensis St. Hil.) on pentylenetetrazol-induced seizures in Wistar rats. ( Branco, Cdos S; Cesio, V; Coitinho, AS; de Freitas, SC; Dos Santos, MT; Fank, B; Heinzen, H; Laprovitera, M; Rodrigues, AD; Salvador, M; Scola, G, 2013) |
| "Recurrent generalized seizures were caused by repetitive injection of pentylenetetrazol (PTZ) for a period of 4 weeks every other day." | 1.39 | Behavioural and histopathological assessment of the effects of periodic fasting on pentylenetetrazol-induced seizures in rats. ( Coulon, P; Gharakhani, M; Gorji, A; Jafarian, M; Karimzadeh, F; Kazemi, H; Khallaghi, B; Kolivand, PH; Mohamadzadeh, E; Razeghi Jahromi, S, 2013) |
| "Pretreatment with diazepam (DZP) significantly attenuated seizure severity." | 1.39 | Seizures induced by pentylenetetrazole in the adult zebrafish: a detailed behavioral characterization. ( Baggio, S; Battastini, AM; Calcagnotto, ME; Campos, MM; de Oliveira, DL; Dias, RD; Leite, CE; Moro, L; Mussulini, BH; Rico, EP; Rosemberg, DB; Souza, TM; Zenki, KC, 2013) |
| "In the present study, 6-Hz seizure threshold, maximal electroshock seizure threshold (MEST) test, and intravenous pentylenetetrazole (i." | 1.38 | Clavulanic acid does not affect convulsions in acute seizure tests in mice. ( Gasior, M; Nieoczym, D; Socała, K; Wlaź, P, 2012) |
| "Finally, we showed that kainate induced seizures and glycemia were not modified by spadin treatments." | 1.38 | Spadin as a new antidepressant: absence of TREK-1-related side effects. ( Borsotto, M; Coppola, T; Gandin, C; Heurteaux, C; Labbal, F; Mazella, J; Moha Ou Maati, H; Veyssiere, J; Widmann, C, 2012) |
| "In animal convulsion models, some anticonvulsants have been found to suppress oxidative reactions associated with convulsions." | 1.38 | Effects of midazolam and phenobarbital on brain oxidative reactions induced by pentylenetetrazole in a convulsion model. ( Arai, Y; Higuchi, H; Maeda, S; Miyawaki, T; Shimada, M; Tomoyasu, Y, 2012) |
| "pyrethrum (HEAP) root against seizures, seizure-induced oxidative stress and cognitive impairment in experimental models of seizures." | 1.38 | Root extract of Anacyclus pyrethrum ameliorates seizures, seizure-induced oxidative stress and cognitive impairment in experimental animals. ( Gupta, YK; Joshi, S; Mehla, J; Pahuja, M; Reeta, KH, 2012) |
| "Midazolam is a short-acting benzodiazepine that is widely used as an i." | 1.38 | Role of neurosteroids in the anticonvulsant activity of midazolam. ( Dhir, A; Rogawski, MA, 2012) |
| "Valproic acid (VPA) is a major antiepileptic drug (AED) that is less potent than other AEDs." | 1.38 | Synthesis and anticonvulsant evaluation of dimethylethanolamine analogues of valproic acid and its tetramethylcyclopropyl analogue. ( Bialer, M; Shekh-Ahmad, T; Yavin, E, 2012) |
| "Epilepsy is a chronic neurological disorder and well documented to induce cognitive impairment." | 1.38 | Age dependent learning and memory deficit in Pentylenetetrazol kindled mice. ( Goel, RK; Mishra, A, 2012) |
| "During drug development, seizure threshold tests are widely used to identify potential proconvulsant activity of investigational drugs." | 1.38 | Striking differences in proconvulsant-induced alterations of seizure threshold in two rat models. ( Bankstahl, JP; Bankstahl, M; Bloms-Funke, P; Löscher, W, 2012) |
| "In two chronic mouse seizure models this clear tasteless oil was found to be reproducibly anticonvulsant." | 1.38 | Triheptanoin in acute mouse seizure models. ( Borges, K; Sweetman, L; Thomas, NK; Willis, S, 2012) |
| "Atorvastatin has neuroprotective effects, and there is some evidence that nitric oxide is involved in atorvastatin effects." | 1.38 | Chronic administration of atorvastatin induced anti-convulsant effects in mice: the role of nitric oxide. ( Dehpour, AR; Fakhrzad, A; Hassanipour, M; Hassanpour, S; Moezi, L; Shafaroodi, H, 2012) |
| "This reduction of seizure severity was also observed in EEG recording and EEG power analysis." | 1.38 | Anticonvulsant effect of Marsilea quadrifolia Linn. on pentylenetetrazole induced seizure: a behavioral and EEG study in rats. ( Dutta, G; Ghosh, T; Goswami, AR; Mandal, N; Sahu, S, 2012) |
| " A sustained (>20 min) generalized convulsion was induced in Sprague-Dawley juvenile rats by intraperitoneal injection with pentylenetetrazole (PTZ, 70-90 mg/kg) at postnatal day (P) 20." | 1.38 | Endogenous ACh effects on NMDA-induced interictal-like discharges along the septotemporal hippocampal axis of adult rats and their modulation by an early life generalized seizure. ( Mikroulis, AV; Psarropoulou, C, 2012) |
| "First, we repeatedly determined the PTZ seizure threshold by i." | 1.38 | Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy. ( Brandt, C; Löscher, W; Rattka, M, 2012) |
| "EDA has been shown to reduce seizures caused by systemic injection of proconvulsants in an animal model of generalized tonic-clonic seizures." | 1.38 | Effects of ethylenediamine in rodent models of seizure, motor coordination and anxiety. ( Addae, JI; Cruickshank, R; Stone, TW; Walkins, K, 2012) |
| " The results of this study demonstrate a plausible novel anticonvulsant activity of β-carotene at a low dose of 2 mg/kg, with brain-targeted nanodelivery, thus increasing its bioavailability and stability." | 1.38 | Plausible antioxidant biomechanics and anticonvulsant pharmacological activity of brain-targeted β-carotene nanoparticles. ( Ahmed, B; Khan, M; Khan, RA; Yusuf, M, 2012) |
| "At the spontaneous recurrent seizure period, acute stress stimulations such as cat's urine and foot electrical shock were applied to observe the behavioral changes and seizure occurrence." | 1.38 | [Effect of acute stress stimulation on the seizure induction in epileptic model rats]. ( Ju, JG; Li, ST; Li, XR; Lu, QC; Sun, Z; Wu, SJ; Zhou, P, 2012) |
| "seizures were induced in 10-day-old Wistar rats with a single convulsive dose (80μg/g b." | 1.37 | A single episode of neonatal seizures alters the cerebellum of immature rats. ( Lomoio, S; Mares, V; Necchi, D; Scherini, E, 2011) |
| " To conclude, long term administration of topiramate impairs cognitive functions during experimental epilepsy while lamotrigine and oxcarbazepine are safer." | 1.37 | Effect of lamotrigine, oxcarbazepine and topiramate on cognitive functions and oxidative stress in PTZ-kindled mice. ( Agarwal, NB; Agarwal, NK; Mediratta, PK; Sharma, KK, 2011) |
| "The analysis of mean latency to seizure onset of nonprotected animals, for specific doses of alkaloids, showed that (+)-erythravine increased latencies to seizures induced by bicuculline." | 1.37 | Anticonvulsant profile of the alkaloids (+)-erythravine and (+)-11-α-hydroxy-erythravine isolated from the flowers of Erythrina mulungu Mart ex Benth (Leguminosae-Papilionaceae). ( Beleboni, RO; Cunha, AO; dos Santos, WF; Fachim, HA; Faggion, SA; Gavin, AS; Pereira, AM, 2011) |
| "Pretreatment of trimetazidine in all doses showed an ameliorating effect on biochemical alteration induced by PTZ treatment." | 1.37 | Anticonvulsant and antioxidant actions of trimetazidine in pentylenetetrazole-induced kindling model in mice. ( Bharal, N; Jain, S; Khurana, S; Mediratta, PK; Sharma, KK, 2011) |
| "Epilepsy is a common neurological disorder, which is attributed to uncontrollable abnormal hyper-excitability of neurons." | 1.37 | Focused ultrasound-mediated suppression of chemically-induced acute epileptic EEG activity. ( Bystritsky, A; Chung, YA; Fischer, K; Jolesz, FA; Jung, KI; Maeng, LS; Min, BK; Park, SI; Yoo, SS; Zhang, Y, 2011) |
| "To assess clonic seizure threshold, pentylenetetrazole (PTZ) was administered intravenously." | 1.37 | Morphine sensitization in the pentylenetetrazole-induced clonic seizure threshold in mice: role of nitric oxide and μ receptors. ( Baradaran, N; Dehpour, AR; Dehpour, S; Kabiri, T; Moezi, L; Shafaroodi, H, 2011) |
| "In this regard, we used a model of clonic seizures induced by pentylenetetrazole (PTZ) in male NMRI mice to investigate whether morphine and citalopram exhibit additive anticonvulsant effects and, if so, whether this effect is mediated through modulation of 5-HT(3) receptors." | 1.37 | The role of 5-HT(3) receptors in the additive anticonvulsant effects of citalopram and morphine on pentylenetetrazole-induced clonic seizures in mice. ( Bahremand, A; Dehpour, AR; Ebrahimi, A; Fakhfouri, G; Ghasemi, A; Ghasemi, M; Loloee, S; Payandemehr, B; Pourmand, N; Rahimian, R; Ziai, P, 2011) |
| "The closed-loop seizure controller was applied to three Long-Evans rats with spontaneous spike-wave discharges (non-convulsive) and three Long-Evans rats with epileptiform activities induced by pentylenetetrazol (PTZ) injection (convulsive) for evaluation." | 1.37 | Closed-loop seizure control on epileptic rat models. ( Chang, DW; Chiueh, H; Liang, SF; Liao, YC; Shaw, FZ; Young, CP, 2011) |
| "Twice-daily dosing of khat did not produce inhibition of weight gain." | 1.37 | Khat (Catha edulis) and ethanol co-dependence modulate seizure expression in a pentylenetetrazol seizure model. ( Alele, PE; Rujumba, JB, 2011) |
| " Thus we aim to evaluate the effect of an increase in Cstb gene dosage on spontaneous epileptic activity and susceptibility to PTZ-induced seizure." | 1.37 | Characterization of PTZ-induced seizure susceptibility in a down syndrome mouse model that overexpresses CSTB. ( Bizot, JC; Brault, V; Costet, N; Hérault, Y; Martin, B, 2011) |
| " VCU was mainly eliminated by metabolism with a half-life of 2 h." | 1.36 | Evaluation of stereoselective anticonvulsant, teratogenic, and pharmacokinetic profile of valnoctylurea (capuride): a chiral stereoisomer of valproic acid urea derivative. ( Bialer, M; Finnell, RH; Schurig, V; Shimshoni, JA; Wlodarczyk, B; Yagen, B, 2010) |
| "Zolpidem is a widely used hypnotic drug acting via benzodiazepine binding sites on GABA(A) receptors." | 1.36 | Zolpidem is a potent anticonvulsant in adult and aged mice. ( Pericić, D; Vlainić, J, 2010) |
| "There is some evidence that epileptic seizures could be induced or increased by 5-hydroxytryptamine (5-HT) attenuation, while augmentation of serotonin functions within the brain (e." | 1.36 | Seizure susceptibility alteration through 5-HT(3) receptor: modulation by nitric oxide. ( Dehpour, AR; Ghaffarpour, M; Ghasemi, M; Gholipour, T; Riazi, K, 2010) |
| "Levetiracetam (LEV) is a unique antiepileptic drug that preferentially interacts with synaptic vesicle protein 2A (SV2A)." | 1.36 | Antiepileptogenic and anticonvulsive actions of levetiracetam in a pentylenetetrazole kindling model. ( Ishihara, S; Ohno, Y; Sasa, M; Serikawa, T; Terada, R, 2010) |
| "asiatica; and PTZ-induced seizure rats pretreated with diazepam (2mg/kg body wt)." | 1.36 | Evaluation of the anticonvulsant effect of Centella asiatica (gotu kola) in pentylenetetrazol-induced seizures with respect to cholinergic neurotransmission. ( Chetan, PS; Lokanatha, V; Prasad, KS; Rajendra, W; Visweswari, G, 2010) |
| "The first group ("seizure-tested rats") received saline, OA, or DHA (400mg/kg) subcutaneously, and were seizure tested in the maximal PTZ test 1 hour later to confirm the seizure latency measurements at that time." | 1.36 | Acute administration of docosahexaenoic acid increases resistance to pentylenetetrazol-induced seizures in rats. ( Bala, S; Burnham, WM; Jeffrey, MA; Taha, AY; Taha, NM, 2010) |
| "Based on their seizure scores during treatment and in a screening test performed 2 weeks post-treatment, the PTZ-treated animals were retrospectively divided into the kindled group and the unkindled group." | 1.36 | Increased hippocampal T2 in a rat model of pentylenetetrazol-induced kindling correlates with seizure scores. ( Fang, F; Lei, H, 2010) |
| "PTZ provoked clonic convulsions, reduced GABA content, deranged brain redox status, and elevated nitric oxide (NO)." | 1.36 | Magnesium supplementation enhances the anticonvulsant potential of valproate in pentylenetetrazol-treated rats. ( Abdallah, DM; Abdel-Aziz, MT; Arafa, NM; Safar, MM, 2010) |
| "Kindling of seizures induced time-, seizure-, and structure-dependent increases in the local levels of NA, 5-HT, 5-hydroxyindolacetic acid, DA, homovanillic acid, and 3,4-dihydroxyphenylacetic acid." | 1.36 | Time course of changes in the concentrations of monoamines in the brain structures of pentylenetetrazole-kindled rats. ( Bidziński, A; Maciejak, P; Płaźnik, A; Sobolewska, A; Szyndler, J; Turzyńska, D, 2010) |
| "The pathophysiology of idiopathic dystonias is still unknown, but it is regarded as a basal ganglia disorder." | 1.36 | Effects of pharmacological entopeduncular manipulations on idiopathic dystonia in the dt(sz) mutant hamster. ( Hamann, M; Kreil, A; Richter, A; Sander, SE, 2010) |
| "PTZ) or kainic acid (i." | 1.36 | Anticonvulsant and proconvulsant actions of 2-deoxy-D-glucose. ( French, A; Gasior, M; Hartman, AL; Rogawski, MA; Yankura, J, 2010) |
| " Piperine (20 mg/kg orally) was administered along with curcumin to enhance the bioavailability of the latter up to 20-fold more." | 1.36 | Antioxidant potential of curcumin against oxidative insult induced by pentylenetetrazol in epileptic rats. ( Jyothy, A; Munshi, A; Nehru, B; Sharma, V, 2010) |
| "The latency for development of convulsions and mortality rate was recorded in these models using mice." | 1.36 | Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice. ( Bansod, K; Bhutada, P; Dixit, P; Mundhada, D; Mundhada, Y; Umathe, S, 2010) |
| "PTZ injection induced clonic seizures in MCH(1)R-WT mice but failed to induce them in MCH(1)R-KO mice." | 1.36 | Mice lacking Melanin Concentrating Hormone 1 receptor are resistant to seizures. ( Civelli, O; Gohil, K; Okumura, SM; Parks, GS, 2010) |
| " Comparative pharmacokinetic analysis showed that α-Cl-TMCD is less susceptible to liver first-pass effect than α-F-TMCD because of lower total (metabolic) clearance and liver extraction ratio." | 1.36 | Comparative pharmacodynamic and pharmacokinetic analysis of two anticonvulsant halo derivatives of 2,2,3,3-tetramethylcyclopropanecarboxamide, an amide of a cyclic analog of valproic acid. ( Bialer, M; Finnell, RH; Hen, N; Kaufmann, D; Pessah, N; Wlodarczyk, B; Yagen, B, 2010) |
| "We report that brief seizures evoked by electroshock produced an increase in the number of NPY neurons in the dentate hilus and retrosplenial cortex, an effect that lasted 10 weeks." | 1.36 | Seizure-induced changes in neuropeptide Y-containing cortical neurons: Potential role for seizure threshold and epileptogenesis. ( Cardoso, A; Carvalho, LS; Freitas-da-Costa, P; Lukoyanov, NV, 2010) |
| "Pretreatment with celecoxib (2." | 1.36 | Anticonvulsant effect of celecoxib on pentylenetetrazole-induced convulsion: Modulation by NO pathway. ( Dehpour, AR; Hajimirzabeigi, A; Khalilzadeh, O; Maleki, F; Zandieh, A; Zandieh, B, 2010) |
| "Valproic acid (VPA) is a major antiepileptic drug (AED) with efficacy against multiple seizure types." | 1.35 | Increase in antiepileptic efficacy during prolonged treatment with valproic acid: role of inhibition of histone deacetylases? ( Czapp, M; Hoffmann, K; Löscher, W, 2008) |
| "Latency for seizures in control animals was 3,120+/-770 s (S." | 1.35 | Anticonvulsant serotonergic and deep brain stimulation in anterior thalamus. ( Chiang, J; Hinich, M; Mirski, MA; Sherman, D; Ziai, WC, 2009) |
| "Nicotine pretreatment reversed the anti-lipid peroxidative action of sodium valproate in the PTZ-induced seizure model in mice." | 1.35 | Dose-finding study with nicotine as a proconvulsant agent in PTZ-induced seizure model in mice. ( Chakrabarti, A; Medhi, B; Sahai, AK; Sood, N, 2008) |
| "Cholestasis decreased seizure activity and increased lag phase before seizure and both effects were decreased by dithizone injection." | 1.35 | Effect of metal chelating agents on pentylenetetrazole-induced seizure threshold in cholestatic mice. ( Dehpour, AR; Ghasemi, M; Kebriaeezadeh, A; Mehr, SE; Nouri, M; Rayatzadeh, H, 2009) |
| "Quinine, is an anti-malarial drug that specifically blocks connexin 36 (Cx36) at gap junction channels." | 1.35 | Antiepileptic effects of quinine in the pentylenetetrazole model of seizure. ( Nassiri-Asl, M; Torabinejad, B; Zamansoltani, F, 2009) |
| "Single seizure and epilepsy is one of the most commonly encountered neurologic disorders in elderly individuals, arising as a result of complex and often multiple acquired underlying pathologies." | 1.35 | Effects of progesterone on total brain tissue adenosine deaminase activity in experimental epilepsy. ( Alptekin, M; Erkutlu, I; Kurtul, N; Pençe, S; Tan, U, 2009) |
| "nNOS(-/-) mice exhibited severe convulsions following injection with a subconvulsive dose of PTZ (40 mg/kg i." | 1.35 | Paradoxical facilitation of pentylenetetrazole-induced convulsion susceptibility in mice lacking neuronal nitric oxide synthase. ( Itoh, K; Watanabe, M, 2009) |
| "Using model of clonic seizure induced by pentylenetetrazole (PTZ) in male NMRI mice, we investigated whether NO is involved in the effects of cannabinoids on the seizure threshold." | 1.35 | Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB(1) agonist ACEA in the pentylenetetrazole-induced seizure in mice. ( Bahremand, A; Dehpour, AR; Ghasemi, M; Nasrabady, SE; Shafaroodi, H, 2009) |
| "Pentylenetetrazole (PTZ) is a convulsant used to model epileptic seizures in rats." | 1.35 | Pentylenetetrazole-induced seizures affect binding site densities for GABA, glutamate and adenosine receptors in the rat brain. ( Bidmon, HJ; Cremer, CM; Palomero-Gallagher, N; Schleicher, A; Speckmann, EJ; Zilles, K, 2009) |
| "maximal electroshock seizure (MES), subcutaneous pentylenetetrazole (scPTZ), subcutaneous strychnine (scSTY), and subcutaneous picrotoxin (scPIC)-induced seizure threshold tests." | 1.35 | Cyclization of the semicarbazone template of aryl semicarbazones: synthesis and anticonvulsant activity of 4,5-diphenyl-2H-1,2,4-triazol-3(4H)-one. ( Shalini, M; Sriram, D; Stables, JP; Yogeeswari, P, 2009) |
| "It has been described that febrile seizures during infancy increase risk of subsequent non-febrile seizures during the adulthood." | 1.35 | Hyperthermic seizures and hyperthermia in immature rats modify the subsequent pentylenetetrazole-induced seizures. ( Gonzalez-Ramirez, M; Orozco-Suarez, SA; Rocha, L; Salgado-Ceballos, H, 2009) |
| "The intensities of seizures induced by pentylenetetrazol or pilocarpine, as well as the percentages of convulsing mice, were significantly reduced in A(2A) receptor knockout (A(2A)R KO) animals." | 1.35 | Adenosine A2A receptor deficient mice are partially resistant to limbic seizures. ( Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM, 2009) |
| "This type of seizures never appeared in caffeine-treated 25-day-old animals." | 1.35 | Postnatal caffeine treatment affects differently two pentylenetetrazol seizure models in rats. ( Kubová, H; Mares, P; Tchekalarova, J, 2009) |
| "To test this we compared seizure kindling rates using the pentylenetetrazol (PTZ) model of epileptogenesis in sensitized and unsensitized adult Sprague-Dawley rats." | 1.35 | Acceleration of pentylenetetrazol seizure kindling associated with induction of sensitized visual responses evoked by strobe stimulation. ( Manning, KA; Uhlrich, DJ, 2009) |
| "The PTZ-induced seizures gradually increased in intensity." | 1.35 | A revised Racine's scale for PTZ-induced seizures in rats. ( Fabene, PF; Lüttjohann, A; van Luijtelaar, G, 2009) |
| " The present study carried out to evaluate the effect of chronic administration of L-arginine (LA) and L-NAME (LN) on pentylenetetrazole (PTZ) induced epilepsy in ovariectomized (OVX) and naïve female rats." | 1.35 | The effect of L-arginine and L-NAME on pentylenetetrazole induced seizures in ovariectomized rats, an in vivo study. ( Alavi, H; Gorji, A; Hosseini, M; Sadeghnia, HR; Salehabadi, S, 2009) |
| "Actions at ERbeta may underlie some antiseizure effects of T's metabolites." | 1.35 | Antiseizure effects of 3alpha-androstanediol and/or 17beta-estradiol may involve actions at estrogen receptor beta. ( Frye, CA; Rhodes, M; Ryan, A, 2009) |
| "Pretreatment with bumetanide (0." | 1.35 | Age- and dose-specific anticonvulsant action of bumetanide in immature rats. ( Mares, P, 2009) |
| "Epilepsy is a common (50 million patients worldwide) neurological disorder characterized by seizures that are caused by episodic abnormal electrical activity in the brain." | 1.35 | Acute seizure tests in epilepsy research: electroshock- and chemical-induced convulsions in the mouse. ( Gasior, M; Giardina, WJ, 2009) |
| "It suppressed tonic phase of generalized seizures induced by pentetrazol in 7-, 12- and 18-day-old rats and increased their latency in 7- and 12-day-old animals." | 1.35 | Anticonvulsant action of GABA-B receptor agonist SKF97541 differs from that of baclofen. ( Mares, P, 2008) |
| "This study was designed to characterize seizures induced with pentylenetetrazol (PTZ) in marmosets." | 1.35 | Behavioral characterization of pentylenetetrazol-induced seizures in the marmoset. ( Bachiega, JC; Blanco, MM; Cinini, SM; Covolan, L; Mello, LE; Perez-Mendes, P, 2008) |
| "Pretreatment with rofecoxib (1." | 1.35 | Rofecoxib potentiates the anticonvulsant effect of topiramate. ( Akula, KK; Dhir, A; Kulkarni, SK, 2008) |
| "When seizures were induced by systemic injection of kainate, only SST(4) knock-outs showed an increase in seizure sensitivity." | 1.35 | Somatostatin receptor subtype 4 couples to the M-current to regulate seizures. ( de Lecea, L; Hochgeschwender, U; Johnson, B; Qiu, C; Tallent, MK; Zeyda, T, 2008) |
| "The present study showed that epileptic seizures induced by convulsive PTZ challenge during kindling-mediated epileptogenesis in the presence of CD changed both functional and ultrastructural properties of the BBB and considerably enhanced transendothelial vesicular transport, while paracellular pathway was apparently not involved in this setting." | 1.35 | Morphological and functional changes of blood-brain barrier in kindled rats with cortical dysplasia. ( Ahishali, B; Arican, N; Bilgic, B; Ekizoglu, O; Elmas, I; Gurses, C; Kalayci, R; Kaya, M; Kemikler, G; Kucuk, M; Oku, B; Orhan, N; Ustek, D, 2008) |
| "Thus, for these mice, the antiseizure effects of 3*-diol for the chemoconvulsant PTZ occur independent of actions at ERbeta." | 1.35 | Antiseizure effects of 5*-androstane-3*,7beta-diol may be independent of actions at estrogen receptor beta. ( Frye, CA; Ryan, A, 2008) |
| "Occurrence of seizures following long-term oral administration of caffeine (0." | 1.35 | Evidence for the involvement of the adenosine A(2A) receptor in the lowered susceptibility to pentylenetetrazol-induced seizures produced in mice by long-term treatment with caffeine. ( Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM, 2008) |
| "Because seizures represent a strong distressing stimulus, stress-induced proteins such as heat shock proteins might counteract the pathology of increased neuronal excitation." | 1.34 | Pentylenetetrazol-kindling in mice overexpressing heat shock protein 70. ( Ammon-Treiber, S; Angelidis, C; Becker, A; Grecksch, G; Höllt, V; Vezyraki, P, 2007) |
| "On day 64 the escape latency of the seizure group was 82,424 ms +/- 35,622 ms, significantly longer than that of the control group (40,712 ms +/- 29,468 ms, P = 0." | 1.34 | [Long-term effects of recurrent seizures in neonate period on gamma-aminobutyric acid A receptor alpha1 and beta2 subunits expression in adult brain: experiment with rats]. ( Bo, T; Chen, Y; Li, YF; Mao, DA; Zhu, XH, 2007) |
| "Many potential treatments for Alzheimer's disease target amyloid-beta peptides (Abeta), which are widely presumed to cause the disease." | 1.34 | Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. ( Cheng, IH; Gerstein, H; Mucke, L; Palop, JJ; Roberson, ED; Scearce-Levie, K; Wu, T; Yan, F; Yu, GQ, 2007) |
| " In addition, modafinil at 180 mg/kg exerted an antiepileptic effect in the MES model; however, at the same dosage it increased the seizure stage in the PTZ-kindling model." | 1.34 | Modafinil exerts a dose-dependent antiepileptic effect mediated by adrenergic alpha1 and histaminergic H1 receptors in mice. ( Chen, CR; Huang, ZL; Qiu, MH; Qu, WM; Urade, Y; Xu, XH; Yao, MH, 2007) |
| "In the PTZ-induced seizures, KA at doses of 0." | 1.34 | On the anticonvulsant activity of kaurenic acid. ( Daló, NL; Sosa-Sequera, MC; Usubillaga, A, 2007) |
| "However, regarding the seizure modulating properties of both classes of receptors this study investigated whether ultra-low dose cannabinoid antagonist AM251 influences cannabinoid anticonvulsant effects." | 1.34 | Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice. ( Bahremand, A; Dehpour, AR; Ghasemi, M; Gholizadeh, S; Shafaroodi, H; Sharifzadeh, M, 2007) |
| "infusion of PTZ; (2) suppress the seizures (clonic and tonic) and lethality induced by i." | 1.33 | Anti-epileptogenic effect of beta-carotene and vitamin A in pentylenetetrazole-kindling model of epilepsy in mice. ( Narenjkar, J; Sayyah, M; Yousefi-Pour, M, 2005) |
| "Rodent seizure models have significantly contributed to our basic understanding of epilepsy." | 1.33 | Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression. ( Baier, H; Baraban, SC; Castro, PA; Taylor, MR, 2005) |
| "Both extracts can prevent convulsions as well as convulsion-related GABAergic neuron damage in the brain in the prolonged PTZ kindling model." | 1.33 | Study of antiepileptic effect of extracts from Acorus tatarinowii Schott. ( Chen, L; Gao, MM; Liao, WP; Su, T; Sun, WW; Yang, SQ; Yi, YH, 2005) |
| "The latency and incidence of seizures were recorded by an observer who was uninformed of the estrous cycle and dietary treatment conditions of the rats." | 1.33 | Ketogenic diet decreases circulating concentrations of neuroactive steroids of female rats. ( Frye, CA; Harney, JP; Rhodes, ME; Talluri, J, 2005) |
| "All subjects were seizure tested by using the PTZ infusion test." | 1.33 | A comparison of the ability of a 4:1 ketogenic diet and a 6.3:1 ketogenic diet to elevate seizure thresholds in adult and young rats. ( Abdelmalik, PA; Burnham, WM; Clarke, J; Likhodii, S; Nylen, K, 2005) |
| "Agmatine pre-treatment significantly reduced the seizure grade and increased the onset time." | 1.33 | Agmatine reduces extracellular glutamate during pentylenetetrazole-induced seizures in rat brain: a potential mechanism for the anticonvulsive effects. ( Feng, Y; LeBlanc, MH; Regunathan, S, 2005) |
| "High anxiety also leads to higher motor incoordination (as assessed by the number of falls and hind-paw slips), suggesting that this test may be used for combined profiling of anxiety, motor-vestibular anomalies and anxiety-induced motor incoordination in rats." | 1.33 | Behavioural characterization in rats using the elevated alley Suok test. ( Kalueff, AV; Minasyan, A; Tuohimaa, P, 2005) |
| " No tolerance was evident in the intravenous pentylenetetrazol test after twice-daily dosing of ABT-769 (0." | 1.33 | Preclinical profiling and safety studies of ABT-769: a compound with potential for broad-spectrum antiepileptic activity. ( Bennani, Y; Bitner, RS; Chemburkar, SR; Chen, J; Curzon, P; Dart, MJ; Decker, MW; Durmuller, N; Fox, GB; Giardina, WJ; Grayson, GK; Harris, RR; Hui, JY; Jolly, R; Komater, VA; Ku, Y; Lockwood, M; Marsh, KC; Miner, HM; Nikkel, AL; Pan, JB; Pu, YM; Radek, RJ; Roux, S; Sullivan, JP; Wang, L; Waring, JF, 2005) |
| "Pentylenetetrazole (PTZ) is a chemical kindling agent used to examine the efficacy of potential anticonvulsants in rats." | 1.33 | Spatial learning deficits and emotional impairments in pentylenetetrazole-kindled rats. ( Dunbar, GL; Ericson, M; Hulce, VD; Mortazavi, F; Story, D, 2005) |
| "Our findings suggest that VDRs modulate seizure susceptibility in mice, and that the Vitamin D/VDR endocrine system may be involved in the pathogenesis of epilepsy." | 1.33 | Increased severity of chemically induced seizures in mice with partially deleted Vitamin D receptor gene. ( Kalueff, AV; Keisala, T; Kuuslahti, M; Miettinen, S; Minasyan, A; Tuohimaa, P, 2006) |
| "Seizures were observed and evaluated regard to latency and intensity for an hour." | 1.33 | Erythropoietin prevents the increase in blood-brain barrier permeability during pentylentetrazol induced seizures. ( Bahçekapili, N; Sarper Diler, A; Uzüm, G; Ziya Ziylan, Y, 2006) |
| "Kainate-induced seizures decrease zinc concentrations in the hippocampus, which is also decreased in young mice fed a zinc-deficient diet for 4 weeks, and is enhanced by zinc deficiency." | 1.33 | Region-specific loss of zinc in the brain in pentylentetrazole-induced seizures and seizure susceptibility in zinc deficiency. ( Hirate, M; Itoh, H; Oku, N; Takeda, A, 2006) |
| "Ethosuximide (ESM) also was used to block seizure activity." | 1.33 | Imaging the neural substrates involved in the genesis of pentylenetetrazol-induced seizures. ( Brevard, ME; Ferris, CF; King, JA; Kulkarni, P, 2006) |
| "In addition, convulsive seizure activity was induced by systemic administration of either 4-aminopyridine (4-AP; 10 mg/kg, i." | 1.33 | Altered seizure susceptibility in mice lacking the Ca(v)2.3 E-type Ca2+ channel. ( Henry, M; Hescheler, J; Kamp, M; Krieger, A; Radhakrishnan, K; Schneider, T; Weiergräber, M, 2006) |
| "Onset, duration of clonic convulsions and percentage mortality/recovery were recorded." | 1.33 | Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: Possible mechanism of action. ( Dhir, A; Kulkarni, SK; Naidu, PS, 2006) |
| "At subthreshold doses for seizure induction, picrotoxin produced an increased frequency of motor neuron action potential bursting, indicating that CNS GABAergic transmission regulates patterned activity." | 1.33 | Development of a Drosophila seizure model for in vivo high-throughput drug screening. ( Chouinard, SW; Littleton, JT; Saraswati, S; Stilwell, GE, 2006) |
| "The KD failed to suppress seizures in either of the tests involving suprathreshold stimulation (MMT and MES), although there was a significant increase in latency in the MMT test." | 1.32 | The effect of the 'classic' ketogenic diet on animal seizure models. ( Chow, C; Cunnane, S; McIntyre Burnham, W; Thavendiranathan, P, 2003) |
| "No spontaneous seizures occurred and no EEG differences were observed between the genotypes in drug naïve mice." | 1.32 | Electroencephalographic characterisation of pentylenetetrazole-induced seizures in mice lacking the alpha 4 subunit of the neuronal nicotinic receptor. ( Berkovic, SF; Drago, J; Finkelstein, DI; Horne, MK; McColl, CD; Wong, JY, 2003) |
| "Seizure activity was observed and seizure patterns and convulsion times were recorded." | 1.32 | Changes in the blood-brain barrier permeability and in the brain tissue trace element concentrations after single and repeated pentylenetetrazole-induced seizures in rats. ( Ates, N; Ilbay, G; Sahin, D, 2003) |
| "Epileptic seizures originating from the limbic system have been shown to stimulate the proliferation rate of granule cell precursors in the adult brain, but it is not clear if other type(s) of seizures have the similar effects." | 1.32 | Dentate granule cell neurogenesis after seizures induced by pentylenetrazol in rats. ( Huang, YG; Jiang, W; Rao, ZR; Wan, Q; Wang, WD; Zhang, X; Zhang, ZJ, 2003) |
| "With pentylenetetrazol (PTZ) induced seizures pre-treated by CBZ, or SR-3, both CBZ and SR-3 were equally effective in providing seizure control and both were superior to the saline control." | 1.32 | Anticonvulsant efficiency, behavioral performance and cortisol levels: a comparison of carbamazepine (CBZ) and a fatty acid compound (SR-3). ( Mostofsky, DI; Rabinovitz, S; Yehuda, S, 2004) |
| " This study was designed to assess the antiepileptic activity of aspirin and to investigate the potentiation of its activity in combination with a subconvulsive dose of lamotrigine." | 1.32 | Evaluation of antiepileptic activity of aspirin in combination with newer antiepileptic lamotrigine in mice. ( Anuradha, K; Pandhi, P; Tandon, M, 2003) |
| "Experimental seizure models can be employed to identify potentially useful combinations for subsequent clinical evaluation." | 1.32 | Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models. ( Brodie, MJ; Butler, E; Sills, GJ; Thompson, GG, 2004) |
| "It remains unclear whether the seizures result from aberrant neuronal placement, disruption of intrinsic properties of neurons, or both." | 1.32 | Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans. ( Braden, AL; Caldwell, GA; Caldwell, KA; Locke, CJ; Williams, SN, 2004) |
| "Convulsions are common complications of shigellosis in children." | 1.32 | Involvement of the neuropeptide corticotropin-releasing hormone in an animal model of Shigella-related seizures. ( Ashkenazi, S; Chrousos, GP; Ovadia, H; Weizman, A; Yuhas, Y, 2004) |
| "increases seizure susceptibility." | 1.32 | Continuous increase of epileptogenic effects following application of proteolytic enzymes (buccal ganglia of Helix pomatia). ( Altrup, U; Joschko, A; Ure, A, 2004) |
| "Regarding the seizure-modulating properties of both classes of receptors, the present study examined the possibility of a functional interaction between these receptors." | 1.32 | The interaction of cannabinoids and opioids on pentylenetetrazole-induced seizure threshold in mice. ( Dehpour, AR; Hajrasouliha, AR; Homayoun, H; Moezi, L; Sadeghipour, H; Samini, M; Shafaroodi, H; Tavakoli, S, 2004) |
| "Reports suggest that Alzheimer's disease (AD) patients show a high life-time prevalence of seizure-like disorders." | 1.32 | Increased seizure threshold and severity in young transgenic CRND8 mice. ( Del Vecchio, RA; Gold, LH; Hyde, LA; Novick, SJ; Wong, G, 2004) |
| "In PTZ seizure model Kyo and its analogues exerted strong inhibition on seizure intensity compared with control group." | 1.32 | Effects of kyotorphin and analogues on nociception and pentylenetetrazole seizures. ( Bocheva, AI; Dzambazova-Maximova, EB, 2004) |
| "Epilepsy is one of the most common but genetically complex neurological disorders in humans." | 1.32 | Genetic and phenotypic analysis of seizure susceptibility in PL/J mice. ( Ernest, S; Frankel, WN; Friedman, L; Gallaugher, L; Kitami, T; Nadeau, JH, 2004) |
| "After pentylenetetrazol-induced seizures: (i) S100B values increased from 10 to 30 min, returning to control levels at 24 h; NSE levels presented a biphasic increase: an increase at 10 to 30 min returning to control levels, and again at 240 min followed by a decline at 24 h; (ii) nucleotidase activities increased from 10 min, returning to control levels at 240 min; (iii) guanosine and inosine levels increased exclusively after 30 min." | 1.32 | Biochemical brain markers and purinergic parameters in rat CSF after seizure induced by pentylenetetrazol. ( Casali, EA; Lara, DR; Leke, R; Oses, JP; Portela, LV; Sarkis, JJ; Schmidt, AP; Souza, DO; Wofchuk, S, 2004) |
| "Ketogenic diets have been used to treat seizure disorders of children resistant to conventional anti-epileptic drug treatment." | 1.32 | Ketogenic diet fed rats have low levels of S100B in cerebrospinal fluid. ( Gonçalves, CA; Gonçalves, D; Leite, M; Mendez, A; Oliveira, DL; Perry, ML; Pires, C; Portela, LV; Ribeiro, L; Tramontina, F; Wofchuk, ST; Ziegler, DR, 2004) |
| "Progestins can have profound effects on seizure processes." | 1.32 | Progestins in the hippocampus of female rats have antiseizure effects in a pentylenetetrazole seizure model. ( Frye, CA; Rhodes, ME, 2004) |
| " In dose-response studies, DOC suppressed MMT seizures with an ED(50) of about 5 mg/kg (sc)." | 1.31 | Dose-, time-, age-, and sex-response profiles for the anticonvulsant effects of deoxycorticosterone in 15-day-old rats. ( Burnham, WM; Edwards, HE; Vimal, S, 2002) |
| "All rats given PTZ developed recurrent seizures." | 1.31 | Maternal deprivation stress exacerbates cognitive deficits in immature rats with recurrent seizures. ( Holmes, GL; Huang, LT; Hung, PL; Lai, MC; Liou, CW; Wang, CL; Wang, TJ; Yang, CH; Yang, SN, 2002) |
| "On the other hand, STT had no effect on convulsions in fully pentylenetetrazol-kindled mice." | 1.31 | Effect of shitei-to, a traditional Chinese medicine formulation, on pentylenetetrazol-induced kindling in mice. ( Fukuda, T; Minami, E; Nomoto, M; Shibata, H, 2000) |
| "Seizures are also often associated with tics and compulsions, which likewise involve cortical-limbic hyperactivity." | 1.31 | TS+OCD-like neuropotentiated mice are supersensitive to seizure induction. ( Burton, FH; Campbell, KM; McGrath, MJ; Veldman, MB, 2000) |
| " GTCSs were suppressed by TGB in the adult and 25-day-old rats, and a U-shaped dose-response curve was outlined in these two groups." | 1.31 | Two different anticonvulsant actions of tiagabine in developing rats. ( Haugvicová, R; Kubová, H; Mares, P; Skutová, M; Suchomelová, L, 2000) |
| "The role of morphine-dependence on the seizure susceptibility has been evaluated with models of pentylenetetrazol (PTZ)-kindling and acute convulsions induced by PTZ, N-methyl-D-aspartic acid (NMDA), picrotoxin and caffeine in adult male rats." | 1.31 | Chemical kindling and seizure susceptibility in morphine dependent rats. ( Atapour, N; Kalantaripour, TP; Niazi, M; Nourpanah, M, 2000) |
| "Convulsions were followed by significant increase in the tail-flick latencies (TFL), at least for 30 min of the post-ictal period." | 1.31 | Post-ictal analgesia: involvement of opioid, serotoninergic and cholinergic mechanisms. ( Castro-Souza, C; Coimbra, NC; Garcia-Cairasco, N; Herrero, CF; Nora, JE; Segato, EN; Tedeschi-Filho, W, 2001) |
| "Other childhood seizures are also responsive to ACTH." | 1.31 | The effects of ACTH and adrenocorticosteroids on seizure susceptibility in 15-day-old male rats. ( Burnham, WM; Edwards, HE; Vimal, S, 2002) |
| "The decrease in the seizure threshold for pentylenetetrazole during diazepam withdrawal was inhibited by pretreatment with MK-801 ((+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cycloheptan-5,10-imine maleate), 7-chlorokynurenic acid and ifenprodil." | 1.30 | Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists. ( Misawa, M; Suzuki, T; Tsuda, M, 1997) |
| "rats with a pentylenetetrazole-induced seizure score of 3 or more on a seizure scale ranging from 0 to 6) and death rate compared with those obtained for rats pre-treated with an equivalent intraperitoneal dose (140 mg kg-1) of acepifylline ('equivalent dose' referred to here denotes the theophylline content of the two preparations)." | 1.30 | A comparative study of aminophylline- and acepifylline-induced seizures and death in the chemoconvulsion model in rats. ( Chakrabarti, A; Garg, SK; Saini, HK, 1997) |
| "were studied on seizures induced by subcutaneous injection of pentylenetetrazole (PTZ), a widely used antiepileptic screening test believed to model generalized myoclonic seizures." | 1.30 | Antiepileptic effects of NPY on pentylenetetrazole seizures. ( Woldbye, DP, 1998) |
| "Maximal protection against convulsions was effectively demonstrated by 8-(n-hexylthio)paeonimetabolin I (8) and 8-benzoylthiopaeonimetabolin I (18) at doses of 0." | 1.30 | Anticonvulsant activity of paeonimetabolin-I adducts obtained by incubation of paeoniflorin and thiol compounds with Lactobacillus brevis. ( Abdel-Hafez, AA; El-Gendy, MA; Hattori, M; Mahfouz, NM; Meselhy, MR; Mohamed, TA; Murakami, Y; Nakamura, N; Watanabe, H, 1999) |
| "tended to decrease seizure intensity and at a dose of 10 mg/kg was ineffective at all." | 1.29 | Further evidence for the interactions between angiotensin II and GABAergic transmission in pentylenetetrazol kindling seizures in mice. ( Georgiev, VP; Kambourova, TS; Lazarova, MB, 1995) |
| "This was indicated by a higher mean convulsion score, increased number of mice responding with convulsions, and induction of seizures in animals pretreated with a subepileptic dose of pentylenetetrazol." | 1.29 | An animal model for the study of neurotoxicity of bacterial products and application of the model to demonstrate that Shiga toxin and lipopolysaccharide cooperate in inducing neurologic disorders. ( Ashkenazi, S; Dinari, G; Weizman, A; Yuhas, Y, 1995) |
| "Dexmedetomidine (DEX) is a highly selective alpha 2 agonist with marked sedative and analgesic properties thought to be mediated via reduction of central noradrenergic transmission." | 1.29 | Dexmedetomidine decreases seizure threshold in a rat model of experimental generalized epilepsy. ( McPherson, RW; Mirski, MA; Rossell, LA; Traystman, RJ, 1994) |
| "Midazolam is a water-soluble benzodiazepine proven to be efficacious in sedation, hypnosis, and induction and maintenance of anesthesia." | 1.29 | Intravenous versus intramuscular midazolam in treatment of chemically induced generalized seizures in swine. ( Bradford, SM; Orebaugh, SL, 1994) |
| "However, they do not affect clonic seizures with preserved righting reflexes." | 1.29 | Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis: III. The action of kynurenic acid and glutamic acid diethylester. ( Kusá, R; Mares, P; Roztocilová, L; Velísek, L, 1995) |
| "Pentylenetetrazole was used to induce epileptic activity." | 1.29 | Alterations of neuronal fibers after epileptic activity induced by pentylenetetrazole: fine structure investigated by calcium cytochemistry and neurobiotin labeling (buccal ganglia, Helix pomatia). ( Altrup, U; Speckmann, EJ; Wiemann, M; Wittkowski, W, 1996) |
| "At P14, LC was not affected by seizures." | 1.28 | An experimental model of generalized seizures for the measurement of local cerebral glucose utilization in the immature rat. I. Behavioral characterization and determination of lumped constant. ( de Vasconcelos, AP; el Hamdi, G; Nehlig, A; Vert, P, 1992) |
| "Convulsions were caused by intraabdominal injections of corazol." | 1.28 | [Correlations of convulsive and hypoxic resistance in rats at different stages of ontogenesis]. ( Agadzhanian, NA; Starykh, EV; Torshin, VI, 1991) |
| " The Type I pyrethroid, cismethrin (15 mg/kg, po), produced a 17% reduction in the threshold dosage of ip-PTZ required to induce a seizure, while delaying the onset of generalized seizure activity." | 1.28 | An examination of the proconvulsant actions of pyrethroid insecticides using pentylenetetrazol and amygdala kindling seizure models. ( Acheson, SK; Crofton, KM; Gilbert, ME; Mack, CM, 1990) |
| "Previous models for febrile convulsions have used environmentally induced hyperthermia as the stimulus to induce convulsions." | 1.27 | Changes in response to metrazole during fever in juvenile rats; a new model for febrile convulsions? ( Baird-Lambert, J; Buchanan, N; MacKintosh, DA, 1984) |
| " In a separate experiment, Ro 15-1788 produced a PTZ-like stimulus when given at 2-day intervals during chronic administration of DZP." | 1.27 | Withdrawal from diazepam substitutes for the discriminative stimulus properties of pentylenetetrazol. ( Emmett-Oglesby, MW; Harris, CM; Idemudia, SO; Lal, H; Mathis, DA, 1988) |
| " The PTZ infusion model was tested in a preliminary dose-response study of the anticonvulsant valproic acid (VPA)." | 1.27 | A timed intravenous pentylenetetrazol infusion seizure model for quantitating the anticonvulsant effect of valproic acid in the rat. ( Pollack, GM; Shen, DD, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 60 (5.77) | 18.7374 |
| 1990's | 64 (6.16) | 18.2507 |
| 2000's | 241 (23.20) | 29.6817 |
| 2010's | 535 (51.49) | 24.3611 |
| 2020's | 139 (13.38) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 4 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Ping, X | 1 |
| Chai, Z | 1 |
| Wang, W | 5 |
| Ma, C | 1 |
| White, FA | 1 |
| Jin, X | 1 |
| Shahpari, MS | 1 |
| Namavar, MRN | 1 |
| Kamali Dolatabadi, LKD | 1 |
| Aligholi, HA | 1 |
| Emamghoreishi, ME | 1 |
| Knox, KM | 1 |
| Zierath, DK | 1 |
| White, HS | 5 |
| Barker-Haliski, M | 2 |
| Wang, L | 9 |
| Ding, J | 2 |
| Zhu, C | 1 |
| Guo, B | 1 |
| Yang, W | 1 |
| He, W | 2 |
| Li, X | 5 |
| Wang, Y | 11 |
| Wang, F | 2 |
| Sun, T | 1 |
| Ren, Q | 1 |
| Gao, D | 1 |
| Mou, L | 1 |
| Zhang, S | 3 |
| Zhang, M | 1 |
| Li, N | 1 |
| Sik, A | 2 |
| Jin, M | 3 |
| Liu, K | 2 |
| Taskiran, M | 2 |
| Unal, G | 1 |
| Siddiqui, MA | 1 |
| Akhter, J | 1 |
| Junaid Bashir, D | 1 |
| Manzoor, S | 1 |
| Rastogi, S | 1 |
| Arora, I | 1 |
| Aggarwal, NB | 1 |
| Samim, M | 1 |
| de Calbiac, H | 1 |
| Dabacan, A | 1 |
| Muresan, R | 1 |
| Kabashi, E | 1 |
| Ciura, S | 1 |
| Shmakova, AA | 1 |
| Rysenkova, KD | 1 |
| Ivashkina, OI | 1 |
| Gruzdeva, AM | 1 |
| Klimovich, PS | 1 |
| Popov, VS | 1 |
| Rubina, KA | 1 |
| Anokhin, KV | 1 |
| Tkachuk, VA | 1 |
| Semina, EV | 1 |
| Uttl, L | 1 |
| Hložek, T | 1 |
| Mareš, P | 19 |
| Páleníček, T | 1 |
| Kubová, H | 8 |
| Filiz, AK | 2 |
| Karabulut, S | 2 |
| Khatami, P | 3 |
| Mirazi, N | 4 |
| Khosravi, M | 2 |
| Bananej, M | 2 |
| El-Hefnawy, MA | 1 |
| Yehia, A | 2 |
| Nashar, EME | 1 |
| Saad, S | 2 |
| Obydah, W | 2 |
| Alghamdi, MA | 2 |
| Alasmari, WA | 2 |
| Hussein, AM | 2 |
| El Nashar, EM | 1 |
| Maryoud, A | 1 |
| Kiwan, NA | 1 |
| Nagib, MM | 1 |
| Yasmen, N | 1 |
| Li, L | 4 |
| Hou, R | 1 |
| Yu, Y | 2 |
| Boda, VK | 1 |
| Wu, Z | 1 |
| Jiang, J | 1 |
| Riban, V | 1 |
| Heulard, I | 1 |
| Reversat, L | 1 |
| Si Hocine, H | 1 |
| Verleye, M | 1 |
| Janisset, NRLL | 1 |
| Romariz, SAA | 3 |
| Hashiguchi, D | 1 |
| Quintella, ML | 1 |
| Gimenes, C | 1 |
| Yokoyama, T | 1 |
| Filev, R | 1 |
| Carlini, E | 1 |
| Barbosa da Silva, R | 1 |
| Faber, J | 1 |
| Longo, BM | 2 |
| Wu, L | 1 |
| Qin, Y | 1 |
| Yuan, H | 1 |
| Zhu, Y | 3 |
| Hu, A | 1 |
| Nishi, T | 1 |
| Metcalf, CS | 1 |
| Fujimoto, S | 1 |
| Hasegawa, S | 1 |
| Miyamoto, M | 1 |
| Sunahara, E | 1 |
| Watanabe, S | 1 |
| Kondo, S | 1 |
| Lu, HC | 1 |
| Chang, WJ | 1 |
| Wei Huang, AC | 1 |
| Shyu, BC | 1 |
| Zhou, L | 1 |
| Gao, Y | 1 |
| Lu, H | 2 |
| Liu, W | 1 |
| Xu, X | 4 |
| Xing, B | 1 |
| Liang, X | 1 |
| Wang, N | 3 |
| Jiang, X | 1 |
| Zhao, Q | 1 |
| Shaw, PAG | 1 |
| Panda, SK | 1 |
| Stanca, A | 1 |
| Luyten, W | 2 |
| Aygun, H | 2 |
| Akin, AT | 1 |
| Kızılaslan, N | 1 |
| Sumbul, O | 1 |
| Karabulut, D | 1 |
| Hosseinzadeh, A | 3 |
| Dehdashtian, E | 2 |
| Jafari-Sabet, M | 1 |
| Mehrzadi, S | 3 |
| da Guedes, E | 1 |
| Ribeiro, LR | 4 |
| Carneiro, CA | 1 |
| Santos, AMF | 1 |
| Brito Monteiro, Á | 1 |
| de Andrade, HHN | 1 |
| Castro, RD | 1 |
| Barbosa, FF | 1 |
| Barbosa Filho, JM | 1 |
| de Almeida, RN | 6 |
| Stiebbe Salvadori, MG | 1 |
| Sahin, H | 1 |
| Yucel, O | 1 |
| Emik, S | 1 |
| Senturk, GE | 1 |
| Rzayev, E | 1 |
| Amanvermez, R | 1 |
| Gün, S | 1 |
| Tiryaki, ES | 1 |
| Arslan, G | 1 |
| Doboszewska, U | 4 |
| Sawicki, J | 1 |
| Sajnóg, A | 1 |
| Szopa, A | 2 |
| Serefko, A | 2 |
| Socała, K | 12 |
| Pieróg, M | 7 |
| Nieoczym, D | 11 |
| Mlyniec, K | 1 |
| Nowak, G | 2 |
| Barałkiewicz, D | 1 |
| Sowa, I | 1 |
| Wlaź, P | 12 |
| Dos Santos Heringer, L | 1 |
| Rios Carvalho, J | 1 |
| Teixeira Oliveira, J | 1 |
| Texeira Silva, B | 1 |
| de Souza Aguiar Dos Santos, DM | 1 |
| Martinez Martinez Toledo, AL | 1 |
| Borges Savoldi, LM | 1 |
| Magalhães Portela, D | 1 |
| Adriani Marques, S | 1 |
| Campello Costa Lopes, P | 1 |
| Blanco Martinez, AM | 1 |
| Rocha Mendonça, H | 1 |
| Boroujeni, SS | 1 |
| Solaimanian, S | 2 |
| Jafari, RM | 1 |
| Sabzevari, O | 1 |
| Shafaroodi, H | 20 |
| Maleki, A | 1 |
| Mohammadi, P | 1 |
| Karimi, E | 1 |
| Dehpour, AR | 46 |
| Zhao, X | 1 |
| Cheng, P | 1 |
| Xu, R | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 2 Clinical Trial Testing the Safety and Efficacy of Voronistat in Pediatric Patients With Drug Resistant Epilepsy[NCT03894826] | Phase 2 | 12 participants (Anticipated) | Interventional | 2018-12-10 | Recruiting | ||
| Evaluation of Brain Activity and Oxygenation Using Near-infrared Spectroscopy (NIRS) in Inflammatory Bowel Disease (IBD) Patients[NCT04733456] | 40 participants (Anticipated) | Observational | 2021-04-26 | Recruiting | |||
| Sodium-Glucose Cotransporter-2 Inhibitors: A Potential Novel Treatment for Epilepsy[NCT05512130] | Early Phase 1 | 18 participants (Anticipated) | Interventional | 2022-08-17 | Recruiting | ||
| Randomized, Double Blind, Placebo Controlled, Parallel Design Phase II b Study of Safety and Efficacy of MGCND00EP1 as an Add on Treatment in Children and Adolescents With Resistant Epilepsies[NCT04406948] | Phase 2 | 103 participants (Anticipated) | Interventional | 2023-08-31 | Not yet recruiting | ||
| Focused Ultrasound Neuromodulation for Treatment of Temporal Lobe Epilepsy[NCT03657056] | 0 participants (Actual) | Interventional | 2022-01-31 | Withdrawn (stopped due to No subjects enrolled and IRB record was closed) | |||
| Effect of the Treatment of Vitamin D Deficiency in Drug-resistant Epilepsy[NCT03475225] | Phase 3 | 400 participants (Anticipated) | Interventional | 2018-04-30 | Not yet recruiting | ||
| Phase 2a Levetiracetam Trial for AD-Associated Network Hyperexcitability[NCT02002819] | Phase 2 | 34 participants (Actual) | Interventional | 2014-10-16 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-cog) - The ADAS-cog rating instrument (Rosen et al. 1984) will be used to evaluate the global cognitive functioning. The ADAS-cog is a 70-point scale that includes an assessment of verbal memory, language, orientation, reasoning, and praxis.The score is derived from adding point values from each of its subsections. The higher your score on the ADAS-cog, the better you do. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam (Epileptiform Activity) | -1.0 |
| Placebo (Epileptiform Activity) | 1.5 |
Blood samples intended for Quest Diagnostics LEV and prolactin serum levels (one 6 mL tube) will be processed in the following manner, as outlined in the Quest Diagnostics lab manual. The whole blood will be allowed to clot for 60 minutes and centrifuged at 2200 - 2500 revolutions per minute (RPM) for at least 15 minutes. The resulting serum will be split into 2 cryovials which will be stored at -20°C and immediately shipped for external assessment of LEV and prolactin levels. Prolactin will be assessed via immunoassay. The concentration of LEV in serum will be measured using validated liquid chromatography/tandem mass spectrometry (LC/MS-MS) methods. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | ng/mL (Mean) |
|---|---|
| Levetiracetam | 0.1 |
| Placebo | 0.2 |
Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-cog) - The ADAS-cog rating instrument (Rosen et al. 1984) will be used to evaluate the global cognitive functioning. The ADAS-cog is a 70-point scale that includes an assessment of verbal memory, language, orientation, reasoning, and praxis.The score is derived from adding point values from each of its subsections. The higher your score on the ADAS-cog, the better you do. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | -0.2 |
| Placebo | 0.8 |
Alzheimer's Disease Cooperative Study Activities of Daily Living Scale (ADCS-ADL) - The ADCS-ADL rating instrument (Galasko et al. 1997) will be used to evaluate functional capacity. The ADCS-ADL is a caregiver rated questionnaire. Scores on the 24-item ADCS-ADL range from 0 to 78. A higher score indicates less severity while a lower score indicates greater severity. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | 0.4 |
| Placebo | 0.3 |
ADCS-Clinical Global Impression of Change (ADCS-CGIC) - The ADCS-CGIC is a seven-point scale that gives a global rating of change from baseline (Schneider et al. 1997). The baseline and follow up assessments are based on interviews with the subject and the informant. The ADCS-CGIC is a clinician-rated measure of: global severity at baseline scored from 1 (normal, not at all ill) to 7 (among the most extremely ill patients); and global change at follow-up scored from 1 (marked improvement) to 7 (marked worsening), where 4 indicates no change. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | 4.0 |
| Placebo | 4.0 |
Neuropsychiatric Inventory (NPI) - The NPI (Cummings et al. 1994) will be used to evaluate the severity of behavioral symptoms. The severity scale has scores ranging from 1 to 3 points (1=mild; 2=moderate; and 3=severe) and the scale for assessing caregiver distress has scores ranging from 0 to 5 points (0=no distress; 1=minimal distress; 2=mild distress; 3=moderate distress; 4=severe distress; and 5=extreme distress). (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | -0.8 |
| Placebo | 0.2 |
A 20-minute computer-based virtual navigation test will be used to assess how well a subject can navigate a virtual community to reach a goal destination. The subjects will then be measured on their ability to accurately navigate the virtual community after a period of a few hours. The subject's performance after the study treatment will be compared with results from a baseline assessment done before the study treatment, using statistical tests to assess whether there was any significant change. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | correct turns (Mean) |
|---|---|
| No Epileptiform Activity | -6.0 |
| Epileptic Activity | 17.4 |
"Epileptiform activity will be measured using a 1-hr resting magnetoencephalogram/electroencephalogram (M/EEG). M/EEG can detect abnormal epileptiform findings called spikes. The M/EEG will be read by an epileptologist with specialized training to assess whether there are any spikes. If spikes are observed during the M/EEG they will be counted to determine their frequency (e.g., 5 spikes per 1 hour recording). The frequency of spikes will then be compared to baseline values from before beginning the study treatment, using statistical tests to determine if the frequency changed with treatment." (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | Epileptiform events (Mean) |
|---|---|
| Levetiracetam | -0.1 |
| Placebo | -0.2 |
Changes in executive function were measured using the NIH EXAMINER, a 1-hour computer-based battery of various executive function tasks. The subject's performance after the study treatment will be compared with results from a baseline assessment done before the study treatment, using statistical tests to assess whether there was any significant change. The Examiner assessment consists of the following scales: antisaccade , set shifting , flanker task, dot counting, spatial 1-back, category fluency, and letter fluency. Scores for this task have an indefinite range. Higher scores however do indicate better performance. Scores for this scale were generated using item response theory. For this study, scores with SEs greater than 0.55 were classified as unreliable and excluded from analysis. Composite scores from 2 participants were excluded on this basis.The EXAMINER ranges for the participants in the study were -2.59 to 1.33. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | -0.06 |
| Placebo | -0.14 |
Stroop Test - The Stroop Test (Stroop 1935) will be used to assess executive functions including selective attention, cognitive flexibility and processing speed. Subtasks include Stroop color naming and Stroop interference naming, and each subtask is restricted to 1 minute. The minimum score is 0 and the maximum score is 126. The higher the score the better a participant does. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | 1.5 |
| Placebo | -1.4 |
Clinical Dementia Rating Sum of Boxes (CDR-SOB) - The CDR will be used as a global measure of dementia severity (Morris 1993). The CDR consists of questions addressed to the caregiver/informant. The lowest score one can receive is a 0 and the highest is a 3. Score is measured by getting the mean of the individual scores in each category. Lower scores equate to less dementia severity. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | 0.1 |
| Placebo | 0.1 |
Changes in executive function will be measured using the NIH EXAMINER, a 1-hour computer-based battery of various executive function tasks. The subject's performance after the study treatment will be compared with results from a baseline assessment done before the study treatment, using statistical tests to assess whether there was any significant change. The Examiner assessment consists of the following scales: NIH EXAMINER - antisaccade , NIH EXAMINER - set shifting , NIH EXAMINER - flanker task, NIH EXAMINER - dot counting, NIH EXAMINER - spatial 1-back, NIH EXAMINER - category fluency, and NIH EXAMINER - letter fluency. Scores for this task have an indefinite range. Higher scores however do indicate better performance. Scores for this scale were generated using item response theory (Kramer et al. J Int Neuropsychol Soc. 2014;20(1):11-19. doi:10.1017/S1355617713001094). (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| No Epileptiform Activity | -0.01 |
| Epileptiform Activity | 0.22 |
The One Day Fluctuation Assessment Scale will be used to quantitate fluctuations of dementia symptoms (Walker et al. 2000). The One Day Fluctuation Assessment Scale has a score range of 0-21 points,with higher scores indicatingmore fluctuations. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | 0.3 |
| Placebo | -0.4 |
Two standardized methods will be used to quantitate fluctuations of dementia symptoms: The Clinician Assessment of Fluctuation and the One Day Fluctuation Assessment Scale (Walker et al. 2000). : The Clinician Assessment of Fluctuation (score range,0-12 points, with higher scores indicating more fluctuations),26 the One Day Fluctuation Assessment Scale (score range,0-21 points, with higher scores indicatingmore fluctuations). (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | 0.9 |
| Placebo | 0.1 |
Stroop Test - The Stroop Test (Stroop 1935) will be used to assess executive functions including selective attention, cognitive flexibility and processing speed. Subtasks include Stroop color naming and Stroop interference naming, and each subtask is restricted to 1 minute. The minimum score is 0 and the maximum score is 126. The higher the score the better a participant does. The mean below represents the average change in score between the timepoints for all participants. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam (Epileptiform Activity) | 4.7 |
| Placebo (Epileptiform Activity) | -2.6 |
24 reviews available for pentylenetetrazole and Disease Models, Animal
| Article | Year |
|---|---|
Zebrafish as an Innovative Tool for Epilepsy Modeling: State of the Art and Potential Future Directions.
Topics: Animals; Anticonvulsants; Child; Disease Models, Animal; Epilepsy; Humans; Pentylenetetrazole; Seizu | 2023 |
Validated animal models for antiseizure drug (ASD) discovery: Advantages and potential pitfalls in ASD screening.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; | 2020 |
[Neurobehavioral Comorbidities in Pentylenetetrazol-kindled Mice and Role of the α4β2 Nicotinic Acetylcholine Receptor].
Topics: Animals; Cell Adhesion Molecules, Neuronal; Disease Models, Animal; Down-Regulation; Epilepsy; Isoxa | 2019 |
Experimental Models for the Discovery of Novel Anticonvulsant Drugs: Focus on Pentylenetetrazole-Induced Seizures and Associated Memory Deficits.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Memory D | 2020 |
PTZ kindling model for epileptogenesis, refractory epilepsy, and associated comorbidities: relevance and reliability.
Topics: Animals; Anticonvulsants; Cognitive Dysfunction; Depression; Disease Models, Animal; Drug Resistance | 2021 |
Neuropathological profile of the pentylenetetrazol (PTZ) kindling model.
Topics: Animals; Convulsants; Disease Models, Animal; Hippocampus; Humans; Kindling, Neurologic; Neurons; Pe | 2018 |
METHODS AND CONSIDERATIONS FOR EXPERIMENTAL EVALUATION OF ANTIEPILEPTIC DRUGS.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Humans; Pentylenetetrazole; Seizures | 1999 |
The Search for New Screening Models of Pharmacoresistant Epilepsy: Is Induction of Acute Seizures in Epileptic Rodents a Suitable Approach?
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Electroshock; Epilep | 2017 |
[New perspectives on molecular and genic therapies in Down syndrome].
Topics: Animals; Catechin; Chromosomes, Human, Pair 21; Disease Models, Animal; Down Syndrome; Droxidopa; Dr | 2010 |
Possible therapeutic effects of transcutaneous electrical stimulation via concentric ring electrodes.
Topics: Animals; Convulsants; Disease Models, Animal; Electrodes; Penicillin G; Pentylenetetrazole; Pilocarp | 2010 |
In vivo experimental models of epilepsy.
Topics: Aluminum Hydroxide; Animals; Bicuculline; Cobalt; Convulsants; Disease Models, Animal; Electroshock; | 2010 |
[Impaired memory following repeated pentylenetetrazol treatments in kindled mice].
Topics: Animals; Disease Models, Animal; Epilepsy; Kindling, Neurologic; Memory; Memory Disorders; Mice; Mot | 2012 |
Do preclinical seizure models preselect certain adverse effects of antiepileptic drugs.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Electro | 2002 |
[Treatment of status epilepticus].
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electric Stimulation Therapy; Humans; Ma | 2001 |
Androgens in the hippocampus can alter, and be altered by, ictal activity.
Topics: Androgens; Animals; Disease Models, Animal; Epilepsy; Female; Hippocampus; Humans; Male; Pentylenete | 2004 |
Synergistic combinations of anticonvulsant agents: what is the evidence from animal experiments?
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug I | 2007 |
Behavioral analogues of anxiety. Animal models.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain; Conditioning, Psychological; Convulsants; Disease Mode | 1983 |
Cellular physiology of epileptogenic phenomena. A hint for future therapy by a herbal mixture.
Topics: Animals; Disease Models, Animal; Epilepsy; Forecasting; Membrane Potentials; Mice; Neurons; Pentylen | 1995 |
Clinical significance of animal seizure models and mechanism of action studies of potential antiepileptic drugs.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Synergism; Drug | 1997 |
[Cellular mechanism of seizure discharge and its normalization by a herbal mixture prescription "saikokeishito-ka-shakuyaku" (SK)].
Topics: Animals; Calcium; Cells, Cultured; Chromosome Mapping; Disease Models, Animal; Drug Resistance; Drug | 2001 |
Animal models used in the screening of antiepileptic drugs.
Topics: Acoustic Stimulation; Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, P | 2001 |
Pharmacological models of generalized absence seizures in rodents.
Topics: Animals; Disease Models, Animal; Epilepsy, Absence; Isoxazoles; Penicillins; Pentylenetetrazole; Rod | 1992 |
Cellular physiology of epileptogenic phenomena and its application to therapy against intractable epilepsy.
Topics: Animals; Calcium; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Drugs, Chinese Herbal; E | 1991 |
Benzodiazepines in the treatment of epilepsy. A review.
Topics: Adult; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Disease Models, Animal; Eclampsia; Elec | 1973 |
3 trials available for pentylenetetrazole and Disease Models, Animal
| Article | Year |
|---|---|
Enantioselective pharmacodynamic and pharmacokinetic analysis of two chiral CNS-active carbamate derivatives of valproic acid.
Topics: Animals; Anticonvulsants; Area Under Curve; Carbamates; Central Nervous System; Convulsants; Disease | 2014 |
Pre- and post-conditioning treatment with an ultra-low dose of Δ9-tetrahydrocannabinol (THC) protects against pentylenetetrazole (PTZ)-induced cognitive damage.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cognition Disorders; Disease Models, Animal; Dose-R | 2011 |
Effects of fluoxetine on the anticonvulsant action of valproate and ethosuximide in mouse model of myoclonic convulsions.
Topics: Animals; Anticonvulsants; Antidepressive Agents, Second-Generation; Avoidance Learning; Convulsants; | 2012 |
1012 other studies available for pentylenetetrazole and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Blocking receptor for advanced glycation end products (RAGE) or toll-like receptor 4 (TLR4) prevents posttraumatic epileptogenesis in mice.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Post-Traumatic; Mice; Mice, Knockout; Pentylene | 2021 |
Morphological changes in the substantia nigra pars reticulata of the mice during kindling.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy; Humans; Kindling, Neurologic; Male; Mice; Ne | 2021 |
Continuous seizure emergency evoked in mice with pharmacological, electrographic, and pathological features distinct from status epilepticus.
Topics: Animals; Disease Models, Animal; Electroencephalography; Emergencies; Glial Fibrillary Acidic Protei | 2021 |
Semaglutide attenuates seizure severity and ameliorates cognitive dysfunction by blocking the NLR family pyrin domain containing 3 inflammasome in pentylenetetrazole‑kindled mice.
Topics: Animals; Apoptosis; Cell Line; Cognitive Dysfunction; Cytokines; Disease Models, Animal; Epilepsy; G | 2021 |
Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cluster Analysis; Disease Models, Animal; Epilepsy; Gene | 2021 |
Vortioxetine suppresses epileptiform activity and cognition deficits in a chronic PTZ-induced kindling rat model.
Topics: Animals; Cognition; Disease Models, Animal; Male; Myoclonus; Pentylenetetrazole; Rats; Rats, Wistar; | 2021 |
Resveratrol loaded nanoparticles attenuate cognitive impairment and inflammatory markers in PTZ-induced kindled mice.
Topics: Animals; Antioxidants; Cognitive Dysfunction; Collagen; Disease Models, Animal; Epilepsy; Glutathion | 2021 |
Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Humans; Pentylenetetrazole; Seizures; Zebrafish | 2021 |
Early Induction of Neurotrophin Receptor and miRNA Genes in Mouse Brain after Pentilenetetrazole-Induced Neuronal Activity.
Topics: Animals; Brain; Cell Survival; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; | 2021 |
Anticonvulsive Effects and Pharmacokinetic Profile of Cannabidiol (CBD) in the Pentylenetetrazol (PTZ) or N-Methyl-D-Aspartate (NMDA) Models of Seizures in Infantile Rats.
Topics: Animals; Anticonvulsants; Brain; Cannabidiol; Disease Models, Animal; Epilepsy; Male; N-Methylaspart | 2021 |
Involvement of nitric oxide pathway in the acute anticonvulsant effect of salmon calcitonin in rats.
Topics: Animals; Anticonvulsants; Calcitonin; Disease Models, Animal; Electroencephalography; Nitric Oxide; | 2022 |
Nonsteroidal Anti-inflammatory Drug Oxaprozin is Beneficial Against Seizure-induced Memory Impairment in an Experimental Model of Seizures in Rats: Impact On Oxidative Stress and Nrf2/HO-1 Signaling Pathway.
Topics: Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Male; Memory Disorders; Models, Theo | 2022 |
Effect of vanillic acid on pentylenetetrazole-kindled rats: Nrf2/HO-1, IGF-1 signaling pathways cross talk.
Topics: Animals; Anticonvulsants; Antioxidants; Convulsants; Disease Models, Animal; Epilepsy; Heme Oxygenas | 2022 |
Effects of Stevia rebaudiana Bertoni extracts in the rat model of epilepsy induced by pentylenetetrazol: Sirt-1, at the crossroads between inflammation and apoptosis.
Topics: Animals; Anticonvulsants; Antioxidants; Apoptosis; Convulsants; Disease Models, Animal; Epilepsy; Hi | 2022 |
Inhibition of TRPC3 channels by a novel pyrazole compound confers antiseizure effects.
Topics: Animals; Disease Models, Animal; Mice; Pentylenetetrazole; Pilocarpine; Pyrazoles; Seizures | 2022 |
Stiripentol inhibits spike-and-wave discharges in animal models of absence seizures: A new mechanism of action involving T-type calcium channels.
Topics: Animals; Anticonvulsants; Calcium Channels, T-Type; Dioxolanes; Disease Models, Animal; Electroencep | 2022 |
Partial protective effects of cannabidiol against PTZ-induced acute seizures in female rats during the proestrus-estrus transition.
Topics: Animals; Anticonvulsants; Cannabidiol; Disease Models, Animal; Estrus; Female; Humans; Male; Pentyle | 2022 |
Anti-inflammatory and neuroprotective effects of insulin-like growth factor-1 overexpression in pentylenetetrazole (PTZ)-induced mouse model of chronic epilepsy.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Epilepsy; Hippocampus; Insulin-Like Growt | 2022 |
Anticonvulsive properties of soticlestat, a novel cholesterol 24-hydroxylase inhibitor.
Topics: Animals; Anticonvulsants; Cholesterol 24-Hydroxylase; Disease Models, Animal; Epilepsy; Kindling, Ne | 2022 |
Detection of pentylenetetrazol-induced seizure activity in the 19-21 Hz beta range using a magnetic coil induction method.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy; Magnetic Phenomena; Mice; Pentyle | 2022 |
Topics: Alzheimer Disease; Animals; Anticonvulsants; Cognitive Dysfunction; Disease Models, Animal; Epilepsy | 2023 |
Anticonvulsant activity of oxaprozin in a rat model of pentylenetetrazole-induced seizure by targeting oxidative stress and SIRT1/PGC1α signaling.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Glutathione; Myoclonus; Oxaprozin; Oxidative Stres | 2022 |
Optimization of a locomotion-based zebrafish seizure model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Larva; Locomotio | 2022 |
Electrophysiological, histopathological, and biochemical evaluation of the protective effect of probiotic supplementation against pentylenetetrazole-induced seizures in rats.
Topics: Animals; Anticonvulsants; Dietary Supplements; Disease Models, Animal; Humans; Interleukin-6; Male; | 2023 |
The Effects of Vitamin D3 and Melatonin Combination on Pentylenetetrazole- induced Seizures in Mice.
Topics: Animals; Anticonvulsants; Cholecalciferol; Disease Models, Animal; Epilepsy; Melatonin; Mice; Pentyl | 2022 |
Anticonvulsant Activity of
Topics: Allylbenzene Derivatives; Animals; Anisoles; Anticonvulsants; Disease Models, Animal; Dose-Response | 2022 |
Protective Effects of Intranasally Administrated Oxytocin-Loaded Nanoparticles on Pentylenetetrazole-Kindling Epilepsy in Terms of Seizure Severity, Memory, Neurogenesis, and Neuronal Damage.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Male; Nanoparticles; Neurogenesis; Neurons; | 2022 |
4-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Male; Neuroprotective Agents; Pentylenet | 2022 |
Alterations of Serum Magnesium Concentration in Animal Models of Seizures and Epilepsy-The Effects of Treatment with a GPR39 Agonist and Knockout of the
Topics: Animals; Disease Models, Animal; Epilepsy; Magnesium; Mice; Mice, Knockout; Pentylenetetrazole; Rece | 2022 |
Altered excitatory and inhibitory neocortical circuitry leads to increased convulsive severity after pentylenetetrazol injection in an animal model of schizencephaly, but not of microgyria.
Topics: Animals; Disease Models, Animal; GAP-43 Protein; Mice; Neocortex; Pentylenetetrazole; Polymicrogyria | 2022 |
Opioidergic and nitrergic systems mediate the anticonvulsant effect of mefloquine and chloroquine on seizures induced by pentylenetetrazol and maximal electroshock in mice.
Topics: Animals; Anticonvulsants; Chloroquine; Disease Models, Animal; Electroshock; Mefloquine; Mice; Naltr | 2022 |
Insights into the development of pentylenetetrazole-induced epileptic seizures from dynamic metabolomic changes.
Topics: Alanine; Animals; Anticonvulsants; Asparagine; Citrates; Creatine; Creatinine; Disease Models, Anima | 2022 |
An involvement of COX and 5-LOX pathways in the penicillin- and pentylenetetrazole (PTZ)-induced epilepsy models.
Topics: Animals; Disease Models, Animal; Epilepsy; Penicillins; Pentylenetetrazole; Rats; Rats, Wistar | 2023 |
Activating toll-like receptor 4 after traumatic brain injury inhibits neuroinflammation and the accelerated development of seizures in rats.
Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Inflammation; Interleukin-10; Neuroinfla | 2022 |
Anti-seizure effect of zinc on PTZ-induced epilepsy in rat model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Hippocampus; Mice; Pentylenetetrazole; R | 2022 |
The Anti-Seizure Effect of Liraglutide on Ptz-Induced Convulsions Through its Anti-Oxidant and Anti-Inflammatory Properties.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Antioxidants; Disease Models, Animal; Epilepsy; | 2023 |
Efficacy of 2-Hydroxyflavanone in Rodent Models of Pain and Inflammation: Involvement of Opioidergic and GABAergic Anti-Nociceptive Mechanisms.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cisplatin; Disease Models, Animal; Edema; Flavanones; | 2022 |
Decreased Spire2 Expression is Involved in Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; | 2022 |
Aerobic exercise, alone or combined with an anti-inflammatory drug, reduces the severity of epileptic seizures and levels of central pro-inflammatory cytokines in an animal model of epileptic seizures.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Diazepam; Disease Models, Animal; Epilepsy; Exercise; | 2022 |
Neuroprotective effects of Lasmiditan and Sumatriptan in an experimental model of post-stroke seizure in mice: Higher effects with concurrent opioid receptors or K
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; bcl-2-Associated X Protein; Benzamides; Disease Mo | 2022 |
ZOMEC via the p-Akt/Nrf2 Pathway Restored PTZ-Induced Oxidative Stress-Mediated Memory Dysfunction in Mouse Model.
Topics: Alzheimer Disease; Animals; Antioxidants; Catalase; Disease Models, Animal; Glutathione Transferase; | 2022 |
Preclinical efficacy of cannabidiol for the treatment of early-life seizures.
Topics: Animals; Anticonvulsants; Cannabidiol; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Rats | 2022 |
Imatinib Attenuates Pentylenetetrazole Kindled and Pilocarpine Induced Recurrent Spontaneous Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Imatinib Mesylate; Mice; Pentylenetetraz | 2023 |
3BDO Alleviates Seizures and Improves Cognitive Function by Regulating Autophagy in Pentylenetetrazol (PTZ)-Kindled Epileptic Mice Model.
Topics: 4-Butyrolactone; Animals; Autophagy; Cognition; Disease Models, Animal; Epilepsy; Hippocampus; Kindl | 2022 |
Possible Interaction of Opioidergic and Nitrergic Pathways in the Anticonvulsant Effect of Ivermectin on Pentylenetetrazole-Induced Clonic Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Ivermectin; Mice | 2023 |
Possible Interaction of Opioidergic and Nitrergic Pathways in the Anticonvulsant Effect of Ivermectin on Pentylenetetrazole-Induced Clonic Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Ivermectin; Mice | 2023 |
Possible Interaction of Opioidergic and Nitrergic Pathways in the Anticonvulsant Effect of Ivermectin on Pentylenetetrazole-Induced Clonic Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Ivermectin; Mice | 2023 |
Possible Interaction of Opioidergic and Nitrergic Pathways in the Anticonvulsant Effect of Ivermectin on Pentylenetetrazole-Induced Clonic Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Ivermectin; Mice | 2023 |
Possible Interaction of Opioidergic and Nitrergic Pathways in the Anticonvulsant Effect of Ivermectin on Pentylenetetrazole-Induced Clonic Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Ivermectin; Mice | 2023 |
Possible Interaction of Opioidergic and Nitrergic Pathways in the Anticonvulsant Effect of Ivermectin on Pentylenetetrazole-Induced Clonic Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Ivermectin; Mice | 2023 |
Possible Interaction of Opioidergic and Nitrergic Pathways in the Anticonvulsant Effect of Ivermectin on Pentylenetetrazole-Induced Clonic Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Ivermectin; Mice | 2023 |
Possible Interaction of Opioidergic and Nitrergic Pathways in the Anticonvulsant Effect of Ivermectin on Pentylenetetrazole-Induced Clonic Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Ivermectin; Mice | 2023 |
Possible Interaction of Opioidergic and Nitrergic Pathways in the Anticonvulsant Effect of Ivermectin on Pentylenetetrazole-Induced Clonic Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Ivermectin; Mice | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effect of valproate on sleep patterns disturbed by epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rat | 2023 |
Effect of valproate on sleep patterns disturbed by epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rat | 2023 |
Effect of valproate on sleep patterns disturbed by epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rat | 2023 |
Effect of valproate on sleep patterns disturbed by epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rat | 2023 |
Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats.
Topics: Animals; Anticonvulsants; Cognitive Dysfunction; Cytokines; Diazepam; Disease Models, Animal; Epilep | 2023 |
Chronic stress but not acute stress decreases the seizure threshold in PTZ-induced seizure in mice: role of inflammatory response and oxidative stress.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Disease Models, Animal; Male; Mice; Oxidative Stress; | 2023 |
Antibiotics modulate frequency and early generation of epileptic seizures in zebrafish.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Seizures; Zebr | 2023 |
Anticonvulsant effect of quercetin in pentylenetetrazole (PTZ)-induced seizures in male mice: The role of anti-neuroinflammatory and anti-oxidative stress.
Topics: Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Male; Mice; Mice, Inbred Strains; NL | 2023 |
Inflammation as a target for the treatment of fever-associated epilepsy in zebrafish larvae.
Topics: Animals; Disease Models, Animal; Epilepsy; Fever; Humans; Inflammation; Interleukin-1beta; Interleuk | 2023 |
Immunosuppressant Tacrolimus Treatment Delays Acute Seizure Occurrence, Reduces Elevated Oxidative Stress, and Reverses PGF2α Burst in the Brain of PTZ-Treated Rats.
Topics: Animals; Anticonvulsants; Brain; Dinoprost; Disease Models, Animal; Epilepsy; Humans; Immunosuppress | 2023 |
Neuroprotective effects of Royal Jelly (RJ) against pentylenetetrazole (PTZ)-induced seizures in rats by targeting inflammation and oxidative stress.
Topics: Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Epilepsy; Inflammation; Male; Neurop | 2023 |
Medial prefrontal cortex oxytocin mitigates epilepsy and cognitive impairments induced by traumatic brain injury through reducing neuroinflammation in mice.
Topics: Animals; Anticonvulsants; Brain Injuries, Traumatic; Cognitive Dysfunction; Disease Models, Animal; | 2023 |
Nicorandil Exerts Anticonvulsant Effects in Pentylenetetrazol-Induced Seizures and Maximal-Electroshock-Induced Seizures by Downregulating Excitability in Hippocampal Pyramidal Neurons.
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Hippocampus; | 2023 |
N-acetyl cysteine: A new look at its effect on PTZ-induced convulsions.
Topics: Acetylcysteine; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy; | 2023 |
Anticonvulsant Profile of Selected Medium-Chain Fatty Acids (MCFAs) Co-Administered with Metformin in Mice in Acute and Chronic Treatment.
Topics: AMP-Activated Protein Kinases; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relat | 2023 |
Delayed treatment with ceftriaxone reverses the enhanced sensitivity of TBI mice to chemically-induced seizures.
Topics: Animals; Brain Injuries, Traumatic; Ceftriaxone; Disease Models, Animal; Epilepsy, Post-Traumatic; G | 2023 |
A comparative study to optimize experimental conditions of pentylenetetrazol and pilocarpine-induced epilepsy in zebrafish larvae.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Epilepsy; Larva; Pentylenetetrazole; | 2023 |
Seizure-induced increase in microglial cell population in the developing zebrafish brain.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Kainic Acid; Microglia; Pentylenetetrazole; Seizur | 2023 |
(-)-α-bisabolol exerts neuroprotective effects against pentylenetetrazole-induced seizures in rats by targeting inflammation and oxidative stress.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Inflammation; Male; Memory Disorders; Ne | 2023 |
A Compared Study of Eicosapentaenoic Acid and Docosahexaenoic Acid in Improving Seizure-Induced Cognitive Deficiency in a Pentylenetetrazol-Kindling Young Mice Model.
Topics: Animals; Child; Cognition; Disease Models, Animal; Docosahexaenoic Acids; Eicosapentaenoic Acid; Hum | 2023 |
Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish.
Topics: Acetylcarnitine; Acetylcysteine; Adult; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; | 2023 |
Lateral fluid-percussion injury leads to pituitary atrophy in rats.
Topics: Animals; Brain Injuries, Traumatic; Convulsants; Disease Models, Animal; Electroencephalography; Hum | 2019 |
Electrophysiological and Neurochemical Assessment of Selenium Alone or Combined with Carbamazepine in an Animal Model of Epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Electrodes; Electroencephalography; | 2020 |
Functional characterization of novel bumetanide derivatives for epilepsy treatment.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Bumetanide; Convulsants; Disease Models, Anima | 2020 |
5-Fluorouracil exacerbates cefepime-induced convulsions in pentylenetetrazol-kindled mice.
Topics: Animals; Anti-Bacterial Agents; Cefepime; Convulsants; Disease Models, Animal; Fluorouracil; Kindlin | 2019 |
Fabrication and evaluation of novel quercetin-conjugated Fe
Topics: Animals; Astrocytes; beta-Cyclodextrins; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, Ne | 2019 |
Physical exercise during pregnancy minimizes PTZ-induced behavioral manifestations in prenatally stressed offspring.
Topics: Animals; Behavior, Animal; Convulsants; Disease Models, Animal; Epilepsy; Female; Male; Pentylenetet | 2020 |
Modeling psychiatric comorbid symptoms of epileptic seizures in zebrafish.
Topics: Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Female; GABA Antagonists; Humans; Locomo | 2019 |
Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Colitis; Convulsants; Dextran Sul | 2019 |
Anticonvulsant action of a selective phosphatidylinositol-3-kinase inhibitor LY294002 in pentylenetetrazole-mediated convulsions in zebrafish.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Chromones; Class I Phosphatidylinositol 3-Kinases | 2019 |
Modulatory effects of neuropeptides on pentylenetetrazol-induced epileptic seizures and neuroinflammation in rats.
Topics: Animals; Biomarkers; Calcitonin Gene-Related Peptide; Convulsants; Disease Models, Animal; Ghrelin; | 2019 |
Activation of adenosine receptors modulates the efflux transporters in brain capillaries and restores the anticonvulsant effect of carbamazepine in carbamazepine resistant rats developed by window-pentylenetetrazole kindling.
Topics: Animals; Anticonvulsants; Brain; Capillaries; Carbamazepine; Disease Models, Animal; Drug Resistant | 2020 |
Preparation and Evaluation of Carbamazepine Solid Lipid Nanoparticle for Alleviating Seizure Activity in Pentylenetetrazole-Kindled Mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Compounding; Epilepsy; Humans; | 2019 |
Home-cage monitoring ascertains signatures of ictal and interictal behavior in mouse models of generalized seizures.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Epilepsies, Myoclonic; Mice; Mon | 2019 |
Evaluation of sodium valproate loaded nanoparticles in acute and chronic pentylenetetrazole induced seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Maze Learning; Oxidative Stress; Pentyle | 2019 |
An interaction study of Ocimum sanctum L. and levetiracetam in pentylenetetrazole kindling model of epilepsy.
Topics: Animals; Anticonvulsants; Avoidance Learning; Disease Models, Animal; Drug Therapy, Combination; Epi | 2020 |
Pentylenetetrazole-induced Seizure Susceptibility in the Tau58/4 Transgenic Mouse Model of Tauopathy.
Topics: Animals; Brain; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy; Mice, Inbred | 2020 |
Micronized resveratrol shows promising effects in a seizure model in zebrafish and signalizes an important advance in epilepsy treatment.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Pentylenetetrazole; Resveratrol; Seizures; Treatme | 2020 |
TRPM2 ion channel is involved in the aggravation of cognitive impairment and down regulation of epilepsy threshold in pentylenetetrazole-induced kindling mice.
Topics: Animals; Apoptosis; Astrocytes; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Hippocampus | 2020 |
MiR-379-5p improved locomotor function recovery after spinal cord injury in rats by reducing endothelin 1 and inhibiting astrocytes expression.
Topics: Animals; Astrocytes; Disease Models, Animal; Endothelin-1; Female; Locomotion; MicroRNAs; Oxidative | 2019 |
Prolonged febrile seizure history exacerbates seizure severity in a pentylenetetrazole rat model of epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Glial Fibrillary Acidic Protein; Hippocampus; Male; Penty | 2020 |
Vascular smooth muscle TRPC3 channels facilitate the inverse hemodynamic response during status epilepticus.
Topics: Animals; Brain; Cerebrovascular Circulation; Disease Models, Animal; Electroencephalography; Male; M | 2020 |
Effects of erythropoietin pretreatment on single dose pentylentetrazole-induced seizures in rats.
Topics: Animals; Disease Models, Animal; Erythropoietin; Hippocampus; Male; Memory; Neurons; Neuroprotective | 2020 |
Anticonvulsant Activity of Essential Oil From Leaves of Zhumeria majdae (Rech.) in Mice: The Role of GABA
Topics: Animals; Anticonvulsants; Arginine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Dr | 2020 |
Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Clonazepam; Disease Models, Animal; D | 2020 |
NaV1.1 and NaV1.6 selective compounds reduce the behavior phenotype and epileptiform activity in a novel zebrafish model for Dravet Syndrome.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsies, Myoclonic; gamma-Aminobutyric Acid; Hu | 2020 |
Long-term potentiation enhancing effect of epileptic insult in the CA1 area is dependent on prior-application of primed-burst stimulation.
Topics: Animals; CA1 Region, Hippocampal; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Antagonist | 2020 |
Glaucacetalin E and galphimidin B from Galphimia glauca and their anxiolytic activity.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Disease Models, Animal; Ex | 2020 |
Antiseizure potential of the ancient Greek medicinal plant Helleborus odorus subsp. cyclophyllus and identification of its main active principles.
Topics: Animals; Anticonvulsants; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Respons | 2020 |
Anticonvulsant Effects of Thalidomide on Pentylenetetrazole-Induced Seizure in Mice: A Role for Opioidergic and Nitrergic Transmissions.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Dr | 2020 |
Anti-epileptic activity of daidzin in PTZ-induced mice model by targeting oxidative stress and BDNF/VEGF signaling.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Brain-Derived Neurotrophic Factor; Disease Models, An | 2020 |
Zebrafish model of posttraumatic epilepsy.
Topics: Animals; Behavior, Animal; Blood-Brain Barrier; Brain; Brain Injuries, Traumatic; Convulsants; Disea | 2020 |
The possible role of nitric oxide in anti-convulsant effects of Naltrindole in seizure-induced by social isolation stress in male mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Hippocampus; Male; Mice; Naltrexone; Narcotic Anta | 2020 |
Hyperexcitability and seizures in the THY-Tau22 mouse model of tauopathy.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Electroencephalography; Mice, Inbred C57BL; Mice | 2020 |
Contribution of excess inflammation to a possible rat model of eclamptic reversible posterior leukoencephalopathy syndrome induced by lipopolysaccharide and pentylenetetrazol: A preliminary study.
Topics: Animals; Astrocytes; Blood Pressure; Blood-Brain Barrier; Brain; Disease Models, Animal; Eclampsia; | 2020 |
COX-2-PGE
Topics: Animals; Cognitive Dysfunction; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Epilepsy; Hi | 2020 |
The anticonvulsant effect of sparteine on pentylenetetrazole-induced seizures in rats: a behavioral, electroencephalographic, morphological and molecular study.
Topics: Animals; Anticonvulsants; Behavior, Animal; Biomarkers; Brain; Disease Management; Disease Models, A | 2020 |
Silencing miR-20a-5p inhibits axonal growth and neuronal branching and prevents epileptogenesis through RGMa-RhoA-mediated synaptic plasticity.
Topics: 3' Untranslated Regions; Animals; Axons; Cells, Cultured; Convulsants; Dependovirus; Disease Models, | 2020 |
Effect of aliskiren on the anticonvulsant activity of antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice.
Topics: Amides; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; | 2020 |
Anticonvulsant activity of Valeriana edulis roots and valepotriates on the pentylenetetrazole-induced seizures in rats.
Topics: Animals; Anticonvulsants; Computer Simulation; Disease Models, Animal; Electroencephalography; Ethos | 2021 |
Lacosamide improves biochemical, genotoxic, and mitochondrial parameters after PTZ-kindling model in mice.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Kindling, Neurologic; Lacosamide; | 2021 |
Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility.
Topics: Animals; Chromosome Mapping; Collaborative Cross Mice; Convulsants; Disease Models, Animal; Epilepsy | 2020 |
Synthesis, anticonvulsant, and antinociceptive activity of new 3-(3-methyl-2,5-dioxo-3-phenylpyrrolidin-1-yl)propanamides and 3-phenyl-butanamides.
Topics: Amides; Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Male; Mice; Pain | 2021 |
Integrative analysis of non-targeted lipidomic data and brain structural imaging identifies phosphatidylethanolamine associated with epileptogenesis.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, Neurologic; Lactones; Lipid | 2020 |
Trehalose Ameliorates Seizure Susceptibility in Lafora Disease Mouse Models by Suppressing Neuroinflammation and Endoplasmic Reticulum Stress.
Topics: Animals; Autophagy; Brain; Calcium-Binding Proteins; Disease Models, Animal; Disease Susceptibility; | 2021 |
Cognition and memory impairment attenuation via reduction of oxidative stress in acute and chronic mice models of epilepsy using antiepileptogenic Nux vomica.
Topics: Acute Disease; Animals; Anticonvulsants; Antioxidants; Behavior, Animal; Brain; Chronic Disease; Cog | 2021 |
Environmental enrichment alters neurobehavioral development following maternal immune activation in mice offspring with epilepsy.
Topics: Animals; Anxiety; Behavior, Animal; Cognitive Dysfunction; Convulsants; Disease Models, Animal; Dise | 2021 |
Central deficiency of norepinephrine synthesis and norepinephrinergic neurotransmission contributes to seizure-induced respiratory arrest.
Topics: Acoustic Stimulation; Adrenergic alpha-1 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals | 2021 |
Stress increases susceptibility to pentylenetetrazole-induced seizures in adult zebrafish.
Topics: Animals; Anxiety; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Seizures; Zebrafish | 2021 |
Gut microbiota modulation by both Lactobacillus fermentum MSK 408 and ketogenic diet in a murine model of pentylenetetrazole-induced acute seizure.
Topics: Animals; Diet, Ketogenic; Disease Models, Animal; Gastrointestinal Microbiome; Limosilactobacillus f | 2021 |
D-limonene Inhibits Pentylenetetrazole-Induced Seizure via Adenosine A2A Receptor Modulation on GABAergic Neuronal Activity.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Convulsants; Disease Models, Animal; GABAergi | 2020 |
Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats.
Topics: Adjuvants, Pharmaceutic; Animals; Anticonvulsants; Behavior, Animal; Centella; Cognitive Dysfunction | 2021 |
Effect of Memantine on Pentylenetetrazol-induced Seizures and EEG Profile in Animal Model of Cortical Malformation.
Topics: Animals; Disease Models, Animal; Electroencephalography; Male; Memantine; Pentylenetetrazole; Rats; | 2021 |
Perillyl alcohol decreases the frequency and severity of convulsive-like behavior in the adult zebrafish model of acute seizures.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Dose-Response Relation | 2021 |
Effects of classic antiseizure drugs on seizure activity and anxiety-like behavior in adult zebrafish.
Topics: Age Factors; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Central Nervo | 2021 |
Neurochemical Effects of 4-(2Chloro-4-Fluorobenzyl)-3-(2-Thienyl)-1,2,4-Oxadiazol-5(4H)-One in the Pentylenetetrazole (PTZ)-Induced Epileptic Seizure Zebrafish Model.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Brain Chemistry; Dihydrotestosterone; Disease Models, | 2021 |
Vortioxetine increases absence-like seizures in WAG/Rij rats but decreases penicillin- and pentylenetetrazole-induced seizures in Wistar rats.
Topics: Animals; Depressive Disorder, Major; Disease Models, Animal; Electroencephalography; Epilepsy, Absen | 2021 |
In vivo anticonvulsant activity of 2-propanone-1,3,5,5-trimethyl-2-cyclohexen-1-ylidine in pilocarpine and strychnine induced-seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Male; Mice; Pentylenetetrazole; Pilocarp | 2020 |
Antiseizure potential of peptides from the venom of social wasp Chartergellus communis against chemically-induced seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Pentylenetetrazole; Peptides; Seizures; Wasp Venom | 2021 |
Anticonvulsant effects of the aqueous and methanol extracts from the stem bark of Psychotria camptopus Verdc. (Rubiacaea) in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Epilepsy; Methanol; Mi | 2021 |
A hydrogen sulfide donor suppresses pentylenetetrazol-induced seizures in rats via PKC signaling.
Topics: Animals; Anticonvulsants; Aquaporin 4; Brain Waves; Cytokines; Disease Models, Animal; Hippocampus; | 2021 |
Ameliorating effects of histamine H3 receptor antagonist E177 on acute pentylenetetrazole-induced memory impairments in rats.
Topics: Animals; Behavior, Animal; Disease Models, Animal; GABA Antagonists; Hippocampus; Histamine H3 Antag | 2021 |
Anti-Seizure Activity of 1-Adamantane Carboxylic Acid in Common Experimental Seizure Models: Role of Benzodiazepine-GABAA Receptors.
Topics: Adamantane; Amygdala; Animals; Anticonvulsants; Benzodiazepines; Disease Models, Animal; Electroshoc | 2021 |
Pentylenetetrazol-induced seizures in adult rats are associated with plastic changes to the dendritic spines on hippocampal CA1 pyramidal neurons.
Topics: Animals; Brain-Derived Neurotrophic Factor; CA1 Region, Hippocampal; Dendritic Spines; Disease Model | 2021 |
Protective effects of lamotrigine and vitamin B12 on pentylenetetrazole-induced epileptogenesis in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Hippocampus; Kindling, Neurologic; Lamotrigine; Ma | 2021 |
The modulator action of thiamine against pentylenetetrazole-induced seizures, apoptosis, nitric oxide, and oxidative stress in rats and SH-SY5Y neuronal cell line.
Topics: Animals; Anticonvulsants; Antioxidants; Apoptosis; Brain; Caspase 3; Cell Line; Disease Models, Anim | 2021 |
Pharmacological Activity of Pyrazole Derivatives as an Anticonvulsant for Benefit against Epilepsy.
Topics: Animals; Anticonvulsants; Child; Disease Models, Animal; Epilepsy; Humans; Mice; Pentylenetetrazole; | 2021 |
Evaluation of cytokines expression in the phytoflavonoids treated epileptic rats: An in vivo study.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Brain; Chronic Disease; Cytokines; Disease Model | 2020 |
An optimized method for adult zebrafish brain-tissue dissociation that allows access mitochondrial function under healthy and epileptic conditions.
Topics: Animals; Brain; Cell Respiration; Disease Models, Animal; Energy Metabolism; Epilepsy; Female; Histo | 2021 |
Examination of the antiepileptic effects of valacyclovir using kindling mice- search for novel antiepileptic agents by drug repositioning using a large medical information database.
Topics: Animals; Anticonvulsants; Cefepime; Databases, Factual; Disease Models, Animal; Drug Repositioning; | 2021 |
Cymbopogon citratus (DC.) Stapf, citral and geraniol exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures in zebrafish.
Topics: Acyclic Monoterpenes; Animals; Anticonvulsants; Brain Chemistry; Catalase; Cymbopogon; Disease Model | 2021 |
Neuroprotective effect of both synbiotics and ketogenic diet in a pentylenetetrazol-induced acute seizure murine model.
Topics: Animals; Diet, Ketogenic; Disease Models, Animal; Mice; Neuroprotective Agents; Pentylenetetrazole; | 2021 |
Rhein attenuates PTZ‑induced epilepsy and exerts neuroprotective activity via inhibition of the TLR4-NFκB signaling pathway.
Topics: Animals; Anthraquinones; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy; | 2021 |
Anti-convulsive Effect of Thiamine and Melatonin Combination in Mice: Involvement of Oxidative Stress.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Male; Melatonin; Mice; Oxidative Stress; Pentylene | 2021 |
Rapamycin alleviates memory deficit against pentylenetetrazole-induced neural toxicity in Wistar male rats.
Topics: Animals; Brain; Disease Models, Animal; Kindling, Neurologic; Male; Memory; Memory Disorders; Neuron | 2021 |
Inhibition of Death-associated Protein Kinase 1 protects against Epileptic Seizures in mice.
Topics: Animals; Death-Associated Protein Kinases; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, | 2021 |
The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Humans; Mechanistic Targe | 2022 |
Protective effects of long-term probiotic mixture supplementation against pentylenetetrazole-induced seizures, inflammation and oxidative stress in rats.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Convulsants; Cytokines; Disease Models, Animal; Epile | 2021 |
Anti-seizure effects of walnut peptides in mouse models of induced seizure: The involvement of GABA and nitric oxide pathways.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyr | 2021 |
Identification of curcumin analogues with anti-seizure potential in vivo using chemical and genetic zebrafish larva seizure models.
Topics: Animals; Anticonvulsants; Behavior, Animal; Biological Availability; Curcumin; Disease Models, Anima | 2021 |
Downregulation of CD40L-CD40 attenuates seizure susceptibility and severity of seizures.
Topics: Animals; CD40 Antigens; CD40 Ligand; Disease Models, Animal; Down-Regulation; Epilepsy, Temporal Lob | 2021 |
Loss of Cannabinoid CB1 Receptors Induces Cortical Migration Malformations and Increases Seizure Susceptibility.
Topics: Animals; Cell Movement; Cerebral Cortex; Disease Models, Animal; Disease Susceptibility; Electropora | 2017 |
Transplantation of inhibitory precursor cells from medial ganglionic eminence produces distinct responses in two different models of acute seizure induction.
Topics: Acute Disease; Animals; Disease Models, Animal; Electroshock; Female; Hippocampus; Interneurons; Mal | 2017 |
Anticonvulsant effects of antiaris toxicaria aqueous extract: investigation using animal models of temporal lobe epilepsy.
Topics: Animals; Antiaris; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Administra | 2017 |
P38 MAPK pathway mediates cognitive damage in pentylenetetrazole-induced epilepsy via apoptosis cascade.
Topics: Analysis of Variance; Animals; Apoptosis; Caspase 3; Cognition Disorders; Convulsants; Disease Model | 2017 |
DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy.
Topics: Action Potentials; Animals; Anthracenes; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; D | 2017 |
Adenosine A1 Receptors Play an Important Protective Role Against Cognitive Impairment and Long-Term Potentiation Inhibition in a Pentylenetetrazol Mouse Model of Epilepsy.
Topics: Animals; Caspase 3; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, | 2018 |
Heat induced temperature dysregulation and seizures in Dravet Syndrome/GEFS+ Gabrg2
Topics: Age Factors; Animals; Body Temperature; Convulsants; Disease Models, Animal; Electroencephalography; | 2017 |
The PTZ kindling mouse model of epilepsy exhibits exploratory drive deficits and aberrant activity amongst VTA dopamine neurons in both familiar and novel space.
Topics: Animals; Convulsants; Disease Models, Animal; Dopaminergic Neurons; Epilepsy; Hippocampus; Kindling, | 2017 |
Anticonvulsant profile of the neuroactive steroid, SGE-516, in animal models.
Topics: Action Potentials; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroshock; Frag | 2017 |
Neuronal zinc-α2-glycoprotein is decreased in temporal lobe epilepsy in patients and rats.
Topics: Adipokines; Adolescent; Adult; Animals; Astrocytes; Carrier Proteins; Child; Disease Models, Animal; | 2017 |
Anticonvulsive activity of (1S)-(-)-verbenone involving RNA expression of BDNF, COX-2, and c-fos.
Topics: Animals; Anticonvulsants; Bicyclic Monoterpenes; Brain-Derived Neurotrophic Factor; Cyclooxygenase 2 | 2017 |
Automated analysis of brain activity for seizure detection in zebrafish models of epilepsy.
Topics: Animals; Automation, Laboratory; Brain; Disease Models, Animal; Electroencephalography; Epilepsy; La | 2017 |
Traumatic brain injury causes long-term behavioral changes related to region-specific increases of cerebral blood flow.
Topics: Animals; Brain Injuries, Traumatic; Cerebrovascular Circulation; Conditioning, Psychological; Diseas | 2017 |
Optical mapping of neuronal activity during seizures in zebrafish.
Topics: Animals; Biomarkers; Brain; Calcium; Disease Models, Animal; High-Throughput Screening Assays; Molec | 2017 |
Ferulic Acid Supplementation for Management of Depression in Epilepsy.
Topics: Animals; Anticonvulsants; Brain; Coumaric Acids; Depression; Depressive Disorder; Disease Models, An | 2017 |
A New Rat Model of Seizures Suitable for Screening Antiepileptic Electrical Stimulation Therapies.
Topics: Animals; Convulsants; Disease Models, Animal; Electric Stimulation Therapy; Electrocorticography; El | 2018 |
Replicable in vivo physiological and behavioral phenotypes of the
Topics: Animals; Anxiety; Autistic Disorder; Behavior, Animal; Biomarkers; Convulsants; Disease Models, Anim | 2017 |
Toxoplasmosis accelerates acquisition of epilepsy in rats undergoing chemical kindling.
Topics: Animals; Disease Models, Animal; Epilepsy; Kaplan-Meier Estimate; Kindling, Neurologic; Male; Pentyl | 2017 |
HBK-14 and HBK-15, triple 5-HT
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Disease Models, Animal; Electr | 2017 |
Anticonvulsant effects of thiamine on pentylenetetrazole-induced seizure in mice.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Epilep | 2019 |
Curcumin-loaded chitosan-alginate-STPP nanoparticles ameliorate memory deficits and reduce glial activation in pentylenetetrazol-induced kindling model of epilepsy.
Topics: Animals; Anticonvulsants; Brain; Chronic Disease; Curcumin; Disease Models, Animal; Dose-Response Re | 2017 |
The Effects of Adenosinergic Modulation on Cytokine Levels in a Pentylenetetrazole-Induced Generalized Tonic-Clonic Seizure Model.
Topics: Adenosine; Animals; Brain; Caffeine; Central Nervous System Stimulants; Convulsants; Cytokines; Dise | 2017 |
Increase in seizure susceptibility in sepsis like condition explained by spiking cytokines and altered adhesion molecules level with impaired blood brain barrier integrity in experimental model of rats treated with lipopolysaccharides.
Topics: Animals; Blood-Brain Barrier; Capillary Permeability; Cytokines; Disease Models, Animal; Disease Sus | 2017 |
Vitamin D enhances antiepileptic and cognitive effects of lamotrigine in pentylenetetrazole-kindled rats.
Topics: Animals; Anticonvulsants; Antioxidants; Cholecalciferol; Chronic Disease; Cognition; Disease Models, | 2017 |
Hybrid photoacoustic and electrophysiological recording of neurovascular communications in freely-moving rats.
Topics: Animals; Capillaries; Convulsants; Disease Models, Animal; Electrodes, Implanted; Hemodynamics; Male | 2017 |
Pharmacokinetic and pharmacodynamic interaction of hydroalcoholic extract of Ocimum sanctum with valproate.
Topics: Animals; Anticonvulsants; Antioxidants; Avoidance Learning; Cognition; Disease Models, Animal; Drug | 2017 |
Attenuation of pentylenetrazole-induced acute status epilepticus in rats by adenosine involves inhibition of the mammalian target of rapamycin pathway.
Topics: Adenosine; Adenylate Kinase; Animals; Anticonvulsants; Blotting, Western; Disease Models, Animal; En | 2017 |
Piperine-loaded chitosan-STPP nanoparticles reduce neuronal loss and astrocytes activation in chemical kindling model of epilepsy.
Topics: Alkaloids; Animals; Astrocytes; Benzodioxoles; Chitosan; Disease Models, Animal; Epilepsy; Humans; H | 2018 |
Manual acupuncture improves parameters associated with oxidative stress and inflammation in PTZ-induced kindling in mice.
Topics: Acupuncture Therapy; Animals; Anticonvulsants; Antioxidants; Convulsants; Disease Models, Animal; In | 2017 |
SSa ameliorates the Glu uptaking capacity of astrocytes in epilepsy via AP-1/miR-155/GLAST.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Transporter 1; gamma-Am | 2017 |
Seizure susceptibility in the APP/PS1 mouse model of Alzheimer's disease and relationship with amyloid β plaques.
Topics: Alzheimer Disease; Animals; Benzylamines; Cerebral Cortex; Disease Models, Animal; Disease Susceptib | 2017 |
Quinine and carbenoxolone enhance the anticonvulsant activity of some classical antiepileptic drugs.
Topics: Animals; Anticonvulsants; Carbenoxolone; Convulsants; Disease Models, Animal; Dose-Response Relation | 2018 |
The anticonvulsant activity and cerebral protection of chronic lithium chloride via NMDA receptor/nitric oxide and phospho-ERK.
Topics: Animals; Anticonvulsants; Cells, Cultured; Cerebellum; Cerebral Cortex; Disease Models, Animal; Dizo | 2018 |
CD36 Deficiency Suppresses Epileptic Seizures.
Topics: Action Potentials; Analysis of Variance; Animals; CD36 Antigens; Convulsants; Disease Models, Animal | 2017 |
Kappa opioid receptors regulate hippocampal synaptic homeostasis and epileptogenesis.
Topics: Animals; Cells, Cultured; Central Nervous System Stimulants; Convulsants; Disease Models, Animal; Di | 2018 |
Sub-chronic boldine treatment exerts anticonvulsant effects in mice.
Topics: Animals; Anticonvulsants; Antioxidants; Aporphines; Ascorbic Acid; Brain; Disease Models, Animal; Do | 2018 |
Immature Status Epilepticus: In Vitro Models Reveal Differences in Cholinergic Control and HFO Properties of Adult CA3 Interictal Discharges in Temporal vs Septal Hippocampus.
Topics: Acetylcholinesterase; Animals; CA3 Region, Hippocampal; Disease Models, Animal; Epilepsy; Pentylenet | 2018 |
Modulation of the anticonvulsant effect of swim stress by agmatine.
Topics: Agmatine; Analgesics, Opioid; Animals; Anticonvulsants; Arginine; Disease Models, Animal; Dose-Respo | 2018 |
Region-specific deletions of the glutamate transporter GLT1 differentially affect seizure activity and neurodegeneration in mice.
Topics: Animals; Anticonvulsants; Brain; Cell Death; Disease Models, Animal; DNA-Binding Proteins; Excitator | 2018 |
Dissecting Cell-Type Composition and Activity-Dependent Transcriptional State in Mammalian Brains by Massively Parallel Single-Nucleus RNA-Seq.
Topics: Animals; Cell Nucleus; Centrifugation, Density Gradient; Cerebral Cortex; Disease Models, Animal; Hi | 2017 |
Anticonvulsant effects of acetaminophen in mice: Comparison with the effects of nonsteroidal anti-inflammatory drugs.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Cyclooxygenase Inh | 2018 |
Interactions between GHRH and GABAARs in the brains of patients with epilepsy and in animal models of epilepsy.
Topics: Adult; Animals; Cerebral Cortex; Disease Models, Animal; Epilepsy; Female; Growth Hormone-Releasing | 2017 |
Magnesium sulfate attenuates brain edema by lowering AQP4 expression and inhibits glia-mediated neuroinflammation in a rodent model of eclampsia.
Topics: Animals; Aquaporin 4; Astrocytes; Brain Edema; CA3 Region, Hippocampal; Cytokines; Disease Models, A | 2019 |
Altered expression of GABA-A receptor subunits in the hippocampus of PTZ-kindled rats.
Topics: Animals; Brain Waves; Disease Models, Animal; GABA Plasma Membrane Transport Proteins; Hippocampus; | 2018 |
Maintenance of the Innate Seizure Threshold by Cyclooxygenase-2 is Not Influenced by the Translational Silencer, T-cell Intracellular Antigen-1.
Topics: Animals; Brain; Cyclooxygenase 2; Disease Models, Animal; Gene Expression; Male; Mice, Inbred C57BL; | 2018 |
Role of miR-34c in the cognitive function of epileptic rats induced by pentylenetetrazol.
Topics: Animals; Cognition; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Regulation; Glu | 2018 |
A novel metabolism-based phenotypic drug discovery platform in zebrafish uncovers HDACs 1 and 3 as a potential combined anti-seizure drug target.
Topics: Animals; Animals, Genetically Modified; Anticonvulsants; Disease Models, Animal; Drug Delivery Syste | 2018 |
Embryonic exposure to ethanol increases the susceptibility of larval zebrafish to chemically induced seizures.
Topics: Animals; Convulsants; Disease Models, Animal; Embryo, Nonmammalian; Epilepsy; Ethanol; Larva; Pentyl | 2018 |
Effect of Tadalafil on Seizure Threshold and Activity of Antiepileptic Drugs in Three Acute Seizure Tests in Mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Convulsants; Disease Models, Animal; Dose-Respo | 2018 |
Endophilin A1 mediates seizure activity via regulation of AMPARs in a PTZ-kindled epileptic mouse model.
Topics: Acyltransferases; Animals; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hum | 2018 |
Anticonvulsive effects of endocannabinoids; an investigation to determine the role of regulatory components of endocannabinoid metabolism in the Pentylenetetrazol induced tonic- clonic seizures.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Disease Models, Animal; Endocannabinoids; Glycerides; M | 2018 |
RNA Polymerase 1 Is Transiently Regulated by Seizures and Plays a Role in a Pharmacological Kindling Model of Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Mice, Inbred C57 | 2018 |
Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice.
Topics: Animals; Anticonvulsants; Cannabinoid Receptor Agonists; Diazepam; Disease Models, Animal; Dose-Resp | 2018 |
Overexpression of zinc-α2-glycoprotein suppressed seizures and seizure-related neuroflammation in pentylenetetrazol-kindled rats.
Topics: Adipokines; Animals; Brain Waves; Carrier Proteins; Convulsants; Cytokines; Disease Models, Animal; | 2018 |
Zebrafish-based identification of the antiseizure nucleoside inosine from the marine diatom Skeletonema marinoi.
Topics: Animals; Anticonvulsants; Chemical Fractionation; Diatoms; Disease Models, Animal; Inosine; Magnetic | 2018 |
Neuroprotective effect of Nrf2 activator dimethyl fumarate, on the hippocampal neurons in chemical kindling model in rat.
Topics: Animals; Dimethyl Fumarate; Disease Models, Animal; Hippocampus; Kindling, Neurologic; Male; Neurons | 2018 |
Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor.
Topics: Animals; Bridged-Ring Compounds; Disease Models, Animal; Imidazoles; Larva; Mice; Mice, Inbred C57BL | 2018 |
Corilagin Reduces the Frequency of Seizures and Improves Cognitive Function in a Rat Model of Chronic Epilepsy.
Topics: Animals; Biomarkers; Brain; Carbonic Anhydrases; Catalase; Cell Count; Chronic Disease; Cognition; C | 2018 |
Clarified Açaí (
Topics: Animals; Anticonvulsants; Cells, Cultured; Complex Mixtures; Diazepam; Disease Models, Animal; Euter | 2018 |
Pharmacological Evaluation of Novel Flavone from Morus alba in Pentylenetetrazole-Induced Kindling and Oxidative Stress.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epi | 2018 |
Sinomenine exerts anticonvulsant profile and neuroprotective activity in pentylenetetrazole kindled rats: involvement of inhibition of NLRP1 inflammasome.
Topics: Analysis of Variance; Animals; Anticonvulsants; CARD Signaling Adaptor Proteins; Caspase 1; Convulsa | 2018 |
Semaphorin 4D promotes inhibitory synapse formation and suppresses seizures in vivo.
Topics: Animals; Animals, Newborn; Anticonvulsants; Antigens, CD; Cells, Cultured; Convulsants; Disease Mode | 2018 |
[Establish and use of an epilepsy model in larval zebrafish].
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy; Larva; Nerve Tissue Proteins; Pen | 2016 |
The anti-epileptogenic and cognition enhancing effect of novel 1-[4-(4-benzo [1, 3] dioxol-5-ylmethyl-piperazin-1-yl)-phenyl]-3-phenyl-urea (BPPU) in pentylenetetrazole induced chronic rat model of epilepsy.
Topics: Animals; Cerebral Cortex; Chronic Disease; Cognition; Cognitive Dysfunction; Disease Models, Animal; | 2018 |
Overexpression of miRNA-137 in the brain suppresses seizure activity and neuronal excitability: A new potential therapeutic strategy for epilepsy.
Topics: Adolescent; Adult; Animals; Brain; Disease Models, Animal; Epilepsy; Female; Humans; Inhibitory Post | 2018 |
Synthesis and Anticonvulsant Activity of 3-(alkylamino, alkoxy)-1,3,4,5- Tetrahydro-2H-benzo [b] azepine-2-one Derivatives.
Topics: Alcohols; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Mice; Pentylenet | 2018 |
[PATHOLOGICAL CHANGES DEVELOPMENT IN THE HEART WITH UNDERLYING CONVULSIVE SYNDROME MODEL OF VARIOUS ETIOLOGIES.]
Topics: Adenosine Triphosphate; Animals; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; L-Lact | 2016 |
Pentylenetetrazole-Induced Kindling Mouse Model.
Topics: Animals; Brain; Disease Models, Animal; GABA Antagonists; Injections, Intraperitoneal; Kindling, Neu | 2018 |
TRPV1 mediates the anticonvulsant effects of acetaminophen in mice.
Topics: Acetaminophen; Acetanilides; Acrylamides; Animals; Anticonvulsants; Bridged Bicyclo Compounds, Heter | 2018 |
Asynchronous, bilateral, and biphasic temporally unstructured electrical stimulation of amygdalae enhances the suppression of pentylenetetrazole-induced seizures in rats.
Topics: Amygdala; Animals; Cortical Synchronization; Deep Brain Stimulation; Disease Models, Animal; Drug Re | 2018 |
Acute Boldine Treatment Induces Anti-convulsant Effects in Mice through its Antioxidant Activity.
Topics: Animals; Anticonvulsants; Antioxidants; Aporphines; Ascorbic Acid; Brain; Disease Models, Animal; Do | 2019 |
Evaluation of ghrelin, nesfatin-1 and irisin levels of serum and brain after acute or chronic pentylenetetrazole administrations in rats using sodium valproate.
Topics: Animals; Anticonvulsants; Biomarkers; Brain; Calcium-Binding Proteins; Disease Models, Animal; DNA-B | 2018 |
Upregulation of klotho and erythropoietin contributes to the neuroprotection induced by curcumin-loaded nanoparticles in experimental model of chronic epilepsy.
Topics: Animals; Chronic Disease; Curcumin; Disease Models, Animal; DNA-Binding Proteins; Drug Carriers; Epi | 2018 |
The effect of high-fat diet on seizure threshold in rats: Role of oxidative stress.
Topics: Animals; Cerebellum; Cerebral Cortex; Diet, High-Fat; Disease Models, Animal; Epilepsy; Hippocampus; | 2018 |
Acute foot-shock stress decreased seizure susceptibility against pentylenetetrazole-induced seizures in mice: Interaction between endogenous opioids and cannabinoids.
Topics: Analgesics, Opioid; Animals; Cannabinoid Receptor Antagonists; Convulsants; Disease Models, Animal; | 2018 |
Anticonvulsant effect of anacardic acid in murine models: Putative role of GABAergic and antioxidant mechanisms.
Topics: Anacardic Acids; Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Electroshock; Epile | 2018 |
Modulation of P2X Purinoceptor 3 (P2X3) in Pentylenetetrazole-Induced Kindling Epilepsy in Rats.
Topics: Animals; Benzenesulfonates; Brain; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, Neurolog | 2018 |
A Caenorhabditis elegans assay of seizure-like activity optimised for identifying antiepileptic drugs and their mechanisms of action.
Topics: Animals; Anticonvulsants; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Convulsants; Dise | 2018 |
Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Encephalitis; Epilepsy; G | 2018 |
Anticonvulsant effects after grafting of rat, porcine, and human mesencephalic neural progenitor cells into the rat subthalamic nucleus.
Topics: Animals; Convulsants; Disease Models, Animal; Embryo, Mammalian; Epilepsy; Fetus; gamma-Aminobutyric | 2018 |
Comparative study of alpha- and beta-pinene effect on PTZ-induced convulsions in mice.
Topics: Animals; Anticonvulsants; Bicyclic Monoterpenes; Brain; Bridged Bicyclo Compounds; Disease Models, A | 2019 |
KA-11, a Novel Pyrrolidine-2,5-dione Derived Broad-Spectrum Anticonvulsant: Its Antiepileptogenic, Antinociceptive Properties and in Vitro Characterization.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Male; Mice; Molecular Struct | 2019 |
Ketogenic diet regulates the antioxidant catalase via the transcription factor PPARγ2.
Topics: Animals; Catalase; Convulsants; Diet, Ketogenic; Disease Models, Animal; Enzyme Inhibitors; Gene Exp | 2018 |
Convulsive seizures and EEG spikes after lateral fluid-percussion injury in the rat.
Topics: Animals; Brain Injuries; Brain Waves; Convulsants; Disease Models, Animal; Electroencephalography; E | 2018 |
Non-invasive mapping of glutathione levels in mouse brains by in vivo electron paramagnetic resonance (EPR) imaging: Applied to a kindling mouse model.
Topics: Animals; Brain; Cyclic N-Oxides; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Gluta | 2019 |
Cunaniol-elicited seizures: Behavior characterization and electroencephalographic analyses.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Electroencephalography; Pen | 2018 |
Effects of galanin receptor 2 and receptor 3 knockout in mouse models of acute seizures.
Topics: Animals; Disease Models, Animal; Electroencephalography; Hippocampus; Kainic Acid; Male; Mice; Mice, | 2018 |
Effect of aliskiren, a direct renin inhibitor, on the protective action of antiepileptic drugs against pentylenetetrazole-induced clonic seizures in mice.
Topics: Amides; Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Brain; Disease Models, Anima | 2019 |
PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by influencing synaptic function in the primary motor cortex of rats.
Topics: Animals; Disease Models, Animal; Dystonia; Female; Male; Membrane Proteins; Motor Cortex; Nerve Tiss | 2019 |
Deep brain stimulation probing performance is enhanced by pairing stimulus with epileptic seizure.
Topics: Amygdala; Animals; Convulsants; Deep Brain Stimulation; Disease Models, Animal; Electroencephalograp | 2018 |
Single pentylenetetrazole exposure increases aggression in adult zebrafish at different time intervals.
Topics: Aggression; Animals; Behavior, Animal; Disease Models, Animal; Female; GABA Antagonists; Male; Penty | 2019 |
Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice.
Topics: 4-Aminopyridine; Acute Disease; Animals; Anticonvulsants; Disease Models, Animal; Drug Therapy, Comb | 2018 |
Changing effect of GABA B receptor antagonist CGP46381 after status epilepticus in immature rats.
Topics: Age Factors; Animals; Animals, Newborn; Convulsants; Disease Models, Animal; GABA-B Receptor Antagon | 2019 |
Synthesis, molecular modeling studies, and anticonvulsant evaluation of novel 1-((2-hydroxyethyl)(aryl)amino)-N-substituted cycloalkanecarboxamides and their acetate esters.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Dru | 2018 |
NLRP3 Inflammasome Activation Leads to Epileptic Neuronal Apoptosis.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Convulsants; Disease Models, Anima | 2018 |
Effect of dimethyl fumarate on neuroinflammation and apoptosis in pentylenetetrazol kindling model in rats.
Topics: Animals; Apoptosis; Dimethyl Fumarate; Disease Models, Animal; Epilepsy; Hippocampus; Inflammation; | 2019 |
Arbutin attenuates cognitive impairment and inflammatory response in pentylenetetrazol-induced kindling model of epilepsy.
Topics: Animals; Antigens, Nuclear; Arbutin; Astrocytes; Cognitive Dysfunction; Cytokines; Disease Models, A | 2019 |
Edaravone acts as a potential therapeutic drug against pentylenetetrazole-induced epilepsy in male albino rats by downregulating cyclooxygenase-II.
Topics: Animals; Antioxidants; Brain; Convulsants; Cyclooxygenase 2; Disease Models, Animal; Down-Regulation | 2019 |
High-throughput brain activity mapping and machine learning as a foundation for systems neuropharmacology.
Topics: Animals; Animals, Genetically Modified; Brain; Brain Mapping; Convulsants; Disease Models, Animal; D | 2018 |
Vitamin D protects against hippocampal apoptosis related with seizures induced by kainic acid and pentylenetetrazol in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Caspase 3; Convul | 2019 |
Changes in Functional Properties of Rat Hippocampal Neurons Following Pentylenetetrazole-induced Status Epilepticus.
Topics: Animals; Disease Models, Animal; Electroshock; Female; Hippocampus; Male; Neurons; Patch-Clamp Techn | 2019 |
Levodropropizine suppresses seizure activity in rats with pentylenetetrazol-induced epilepsy.
Topics: Analysis of Variance; Animals; Antitussive Agents; Convulsants; Disease Models, Animal; Electroencep | 2019 |
Expression of cardiac inwardly rectifying potassium channels in pentylenetetrazole kindling model of epilepsy in rats.
Topics: Animals; Autonomic Nervous System; Blood Pressure; Disease Models, Animal; Electrocardiography; Epil | 2018 |
Anticonvulsant Activity of Pterostilbene in Zebrafish and Mouse Acute Seizure Tests.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Disease Models, Animal; Dose-Response Relationship, | 2019 |
Exploratory Cortex Metabolic Profiling Revealed the Sedative Effect of Amber in Pentylenetetrazole-Induced Epilepsy-Like Mice.
Topics: Amber; Animals; Behavior, Animal; Cerebral Cortex; Chromatography, Liquid; Disease Models, Animal; E | 2019 |
Repulsive guidance molecule a suppresses seizures and mossy fiber sprouting via the FAK‑p120RasGAP‑Ras signaling pathway.
Topics: Animals; Disease Models, Animal; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression; GPI-Linke | 2019 |
Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility.
Topics: Animals; Anxiety; Avoidance Learning; Brain Waves; Convulsants; Disease Models, Animal; Disease Susc | 2019 |
Early α-linolenic acid exposure to embryo reduces pentylenetetrazol-induced seizures in zebrafish larva.
Topics: alpha-Linolenic Acid; Animals; Behavior, Animal; Convulsants; Dietary Supplements; Disease Models, A | 2019 |
Vitamin E modifies high-fat diet-induced reduction of seizure threshold in rats: Role of oxidative stress.
Topics: Animals; Antioxidants; Biomarkers; Brain; Catalase; Diet, High-Fat; Disease Models, Animal; Glutathi | 2019 |
PTZ-induced seizures in mice require a revised Racine scale.
Topics: Animals; Convulsants; Disease Models, Animal; Electroencephalography; Female; Male; Mice; Mice, Inbr | 2019 |
Protective effects of M8‑B, a TRPM8 antagonist, on febrile‑ and pentylenetetrazol‑induced seizures.
Topics: Animals; Animals, Newborn; Anticonvulsants; Body Temperature; Convulsants; Disease Models, Animal; D | 2019 |
Evaluation of anticonvulsant and antiepileptogenic activity of Euphorbia nivulia in PTZ-induced kindling model of epilepsy in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy; Euphorbia; | 2019 |
The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Drug Resistance; Epilepsy; Kindling, | 2019 |
Synthetic, non-intoxicating 8,9-dihydrocannabidiol for the mitigation of seizures.
Topics: Animals; Anticonvulsants; Cannabidiol; Cannabinoids; Disease Models, Animal; Male; Pentylenetetrazol | 2019 |
Target identification, screening and in vivo evaluation of pyrrolone-fused benzosuberene compounds against human epilepsy using Zebrafish model of pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Class I Phosphatidylinositol 3-Kinases; Coumarins; Disease Models, Animal; | 2019 |
Role of nitric oxide synthase on brain GABA transaminase activity and GABA levels.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Disease Models, Animal; gamma-Aminobu | 2018 |
The effect of exercise on GABA signaling pathway in the model of chemically induced seizures.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Gene Expression; Glutamate Decarboxylase; | 2019 |
The anticonvulsant and neuroprotective effects of kir2.3 activation in PTZ-induced seizures and the kainic acid model of TLE.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kaini | 2019 |
Chronic exercise buffers the cognitive dysfunction and decreases the susceptibility to seizures in PTZ-treated rats.
Topics: Animals; Cognitive Dysfunction; Disease Models, Animal; Pentylenetetrazole; Physical Conditioning, A | 2019 |
Increased susceptibility to pentetrazol-induced seizures in developing rats after cortical photothrombotic ischemic stroke at P7.
Topics: Animals; Brain; Brain Ischemia; Convulsants; Disease Models, Animal; Electroencephalography; Epileps | 2013 |
Oral gabapentin suppresses pentylenetetrazole-induced seizure-like behavior and cephalic field potential in adult zebrafish.
Topics: Action Potentials; Administration, Oral; Amines; Analysis of Variance; Animals; Anticonvulsants; Bra | 2013 |
Short-term treatment with the GABAA receptor antagonist pentylenetetrazole produces a sustained pro-cognitive benefit in a mouse model of Down's syndrome.
Topics: Animals; Behavior, Animal; Circadian Rhythm; Cognition; Disease Models, Animal; Down Syndrome; Elect | 2013 |
The threshold of pentylenetetrazole-induced convulsive seizures, but not that of nonconvulsive seizures, is controlled by the nitric oxide levels in murine brains.
Topics: Analysis of Variance; Animals; Brain; Convulsants; Disease Models, Animal; Dose-Response Relationshi | 2013 |
Targeted mutation of the gene encoding prion protein in zebrafish reveals a conserved role in neuron excitability.
Topics: Age Factors; Animals; Animals, Genetically Modified; Disease Models, Animal; Epilepsy; Gene Expressi | 2013 |
A unified approach for detection of induced epileptic seizures in rats using ECoG signals.
Topics: Algorithms; Animals; Brain; Convulsants; Databases, Factual; Disease Models, Animal; Disease Progres | 2013 |
BDNF-TrkB signaling pathway is involved in pentylenetetrazole-evoked progression of epileptiform activity in hippocampal neurons in anesthetized rats.
Topics: Administration, Intravenous; Anesthesia, General; Animals; Brain-Derived Neurotrophic Factor; CA1 Re | 2013 |
Antiepileptic activity of lobeline isolated from the leaf of Lobelia nicotianaefolia and its effect on brain GABA level in mice.
Topics: Animals; Anticonvulsants; Brain; Brain Chemistry; Convulsants; Disease Models, Animal; gamma-Aminobu | 2012 |
Pentylenetetrazol-induced seizures are associated with Na⁺,K⁺-ATPase activity decrease and alpha subunit phosphorylation state in the mice cerebral cortex.
Topics: Animals; Cerebral Cortex; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Mal | 2013 |
Adult siRNA-induced knockdown of mGlu7 receptors reduces anxiety in the mouse.
Topics: Adaptation, Ocular; Animals; Anxiety; Disease Models, Animal; Dose-Response Relationship, Drug; Fear | 2013 |
The interaction of adenosine and morphine on pentylenetetrazole-induced seizure threshold in mice.
Topics: Adenosine; Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Inte | 2013 |
The role of potassium BK channels in anticonvulsant effect of cannabidiol in pentylenetetrazole and maximal electroshock models of seizure in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cannabidiol; Convulsants; Disease Models, Animal; Do | 2013 |
Behavioral profile of Hypericum perforatum (St. John's Wort) extract. A comparison with standard antidepressants in animal models of depression.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Hypericum; Male; Mice; Motor Act | 2013 |
Changes in the Egr1 and Arc expression in brain structures of pentylenetetrazole-kindled rats.
Topics: Animals; Brain; Brain Mapping; Cytoskeletal Proteins; Disease Models, Animal; Early Growth Response | 2013 |
Effects of quercetin on oxidative stress and memory retrieval in kindled rats.
Topics: Animals; Antioxidants; Avoidance Learning; Brain; Convulsants; Disease Models, Animal; Dithionitrobe | 2013 |
[Anticonvulsant effect of dicholine succinate on primary generalized epilepsy model in mice].
Topics: Animals; Anticonvulsants; Choline; Convulsants; Disease Models, Animal; Dose-Response Relationship, | 2013 |
Lamotrigine positively affects the development of psychiatric comorbidity in epileptic animals, while psychiatric comorbidity aggravates seizures.
Topics: Animals; Anticonvulsants; Comorbidity; Disease Models, Animal; Epilepsy; Exploratory Behavior; Food | 2013 |
Hyperexcitability and epileptic seizures in a model of frontotemporal dementia.
Topics: Animals; Brain; Calcium-Binding Proteins; Convulsants; Disease Models, Animal; DNA-Binding Proteins; | 2013 |
Effects of intrahippocampal injection of ghrelin on spatial memory in PTZ-induced seizures in male rats.
Topics: Animals; Convulsants; Disease Models, Animal; Ghrelin; Hippocampus; Injections; Male; Maze Learning; | 2013 |
Design and synthesis of some 3-substituted-2-[(2,4-dichlorophenoxy)-methyl]quinazolin-4(3H)-one derivatives as potential anticonvulsant agents.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Design; Female; Hydrazines; Lethal Dose 50; M | 2013 |
Anticonvulsant screening of luteolin in four mouse seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, | 2013 |
Anticonvulsant activity of ethanol extracts of Vetiveria zizanioides roots in experimental mice.
Topics: Animals; Anticonvulsants; Chrysopogon; Convulsants; Disease Models, Animal; Dose-Response Relationsh | 2013 |
The anticonvulsant and sedative effects of Gladiolus dalenii extracts in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Dose-Respon | 2013 |
Anticonvulsant activity of Hypericum scabrum L.; possible mechanism involved.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Sca | 2013 |
Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism.
Topics: Animals; Anticonvulsants; Brain; Cannabidiol; Cannabinoids; Cannabis; Disease Models, Animal; Dose-R | 2013 |
Antisense reduction of tau in adult mice protects against seizures.
Topics: Age Factors; Animals; Anticonvulsants; Central Nervous System; Convulsants; Disease Models, Animal; | 2013 |
Proconvulsant actions of intrahippocampal botulinum neurotoxin B in the rat.
Topics: Animals; Botulinum Toxins; Botulinum Toxins, Type A; Convection; Convulsants; Disease Models, Animal | 2013 |
GABA-A receptor modulators alter emotionality and hippocampal theta rhythm in an animal model of long-lasting anxiety.
Topics: Animals; Anxiety; Diazepam; Disease Models, Animal; Electroencephalography; Emotions; GABA Antagonis | 2013 |
The auriculo-vagal afferent pathway and its role in seizure suppression in rats.
Topics: Action Potentials; Afferent Pathways; Anesthetics; Animals; Cholera Toxin; Convulsants; Disease Mode | 2013 |
Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models.
Topics: Abietanes; Alzheimer Disease; Animals; Anticonvulsants; Brain Ischemia; Disease Models, Animal; Dise | 2013 |
Possible nitric oxide mechanism in the protective effect of hesperidin against pentylenetetrazole (PTZ)-induced kindling and associated cognitive dysfunction in mice.
Topics: Animals; Avoidance Learning; Brain; Cognition Disorders; Convulsants; Disease Models, Animal; Dose-R | 2013 |
Design, synthesis and anticonvulsant properties of new N-Mannich bases derived from 3-phenylpyrrolidine-2,5-diones.
Topics: Administration, Oral; Animals; Anticonvulsants; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhib | 2013 |
GSK-3β may be involved in hippocampal mossy fiber sprouting in the pentylenetetrazole-kindling model.
Topics: Animals; Behavior, Animal; Convulsants; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen | 2013 |
Caffeic acid phenethyl ester prevents apoptotic cell death in the developing rat brain after pentylenetetrazole-induced status epilepticus.
Topics: Analysis of Variance; Animals; Animals, Newborn; Apoptosis; Brain; Caffeic Acids; Caspase 3; Convuls | 2013 |
P-selectin-mediated monocyte-cerebral endothelium adhesive interactions link peripheral organ inflammation to sickness behaviors.
Topics: Alanine Transaminase; Animals; Cell Adhesion; Cerebral Cortex; Cholestasis; Colitis; Cytokines; Dini | 2013 |
Characterization of anticonvulsant and antiepileptogenic potential of thymol in various experimental models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Pent | 2014 |
Design of benzothiazole-1,3,4-thiadiazole conjugates: synthesis and anticonvulsant evaluation.
Topics: Animals; Anticonvulsants; Benzothiazoles; Brain; Disease Models, Animal; Drug Design; Electroshock; | 2013 |
Loss of hippocampal interneurons and epileptogenesis: a comparison of two animal models of acquired epilepsy.
Topics: Animals; Brain Injuries; Brain Waves; Calbindin 2; Cell Death; Cholecystokinin; Convulsants; Disease | 2015 |
Anticonvulsant effects of Fuzi total alkaloid on pentylenetetrazole-induced seizure in mice.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Diterpenes; Dose-Response Relatio | 2013 |
Effect of minocycline on pentylenetetrazol-induced chemical kindled seizures in mice.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Disease Models, Animal; Gene Expression; Hippoca | 2014 |
Different effects of postnatal caffeine treatment on two pentylenetetrazole-induced seizure models persist into adulthood.
Topics: Aging; Animals; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsies, Myoc | 2013 |
Altered cardiac electrophysiology and SUDEP in a model of Dravet syndrome.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cardiac Electrophysiology; Death, Sudden, Cardiac; | 2013 |
Elevated expression of pleiotrophin in pilocarpine-induced seizures of immature rats and in pentylenetetrazole-induced hippocampal astrocytes in vitro.
Topics: Animals; Astrocytes; Blotting, Western; Carrier Proteins; Cell Survival; Cells, Cultured; Cytokines; | 2014 |
Evaluation of anti-epileptic property of Marsilea quadrifolia Linn. in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; Male; Marsileaceae; Pentylenet | 2013 |
Epilepsy in kcnj10 morphant zebrafish assessed with a novel method for long-term EEG recordings.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Disease Models, Animal; Electroencephalograp | 2013 |
Anticonvulsant activity of Aloe vera leaf extract in acute and chronic models of epilepsy in mice.
Topics: Aloe; Animals; Antioxidants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electr | 2014 |
Role of TRPV1 in susceptibility to PTZ-induced seizure following repeated hyperthermia challenges in neonatal mice.
Topics: Analysis of Variance; Animals; Animals, Newborn; Convulsants; Disease Models, Animal; Dose-Response | 2014 |
Effects of single-dose neuropeptide Y on levels of hippocampal BDNF, MDA, GSH, and NO in a rat model of pentylenetetrazole-induced epileptic seizure.
Topics: Animals; Brain-Derived Neurotrophic Factor; Convulsants; Disease Models, Animal; Epilepsy; Glutathio | 2013 |
Novel Vitamin K analogs suppress seizures in zebrafish and mouse models of epilepsy.
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Cell Line; Disease Models, Animal; Dose-Response R | 2014 |
Prostaglandin D(2) is crucial for seizure suppression and postictal sleep.
Topics: 6-Ketoprostaglandin F1 alpha; Analysis of Variance; Animals; Brain; Convulsants; Dinoprostone; Disea | 2014 |
Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy.
Topics: Animals; Anticonvulsants; Behavior, Animal; Blood-Brain Barrier; Brain; Brain-Derived Neurotrophic F | 2013 |
[Comparison of seizure induced by different drugs in ICR Mice].
Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Mice; Mice, Inbred ICR; Pentylenetetra | 2013 |
Cognitive performance and convulsion risk after experimentally-induced febrile-seizures in rat.
Topics: Analysis of Variance; Animals; Cognition Disorders; Convulsants; Disease Models, Animal; Dose-Respon | 2014 |
Comparison between the effects of quercetin on seizure threshold in acute and chronic seizure models.
Topics: Acute Disease; Administration, Oral; Animals; Anticonvulsants; Chronic Disease; Convulsants; Disease | 2016 |
The protective effects of endothelin-A receptor antagonist BQ-123 in pentylenetetrazole-induced seizure in rats.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Endothelin A Receptor Antagonists; Epilepsy | 2014 |
Aggravation of seizure-like events by hydrogen sulfide: involvement of multiple targets that control neuronal excitability.
Topics: 4-Aminopyridine; Animals; Disease Models, Animal; Entorhinal Cortex; Hydrogen Sulfide; Magnesium Def | 2014 |
Acute administration of ginger (Zingiber officinale rhizomes) extract on timed intravenous pentylenetetrazol infusion seizure model in mice.
Topics: Analysis of Variance; Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug | 2014 |
Non-invasive detection of optical changes elicited by seizure activity using time-series analysis of light scattering images in a rat model of generalized seizure.
Topics: Algorithms; Animals; Brain; Brain Mapping; Convulsants; Disease Models, Animal; Electroencephalograp | 2014 |
Positive effect of calcitonin on the seizures induced by pentylenetetrazole in rats.
Topics: Analysis of Variance; Animals; Bone Density Conservation Agents; Brain Waves; Calcitonin; Convulsant | 2014 |
Decreased seizure threshold in an eclampsia-like model induced in pregnant rats with lipopolysaccharide and pentylenetetrazol treatments.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Eclampsia; Female; Humans; Lipopolysaccharides; Ma | 2014 |
Modulation of c-Fos and BDNF protein expression in pentylenetetrazole-kindled mice following the treatment with novel antiepileptic compound HHL-6.
Topics: Animals; Anticonvulsants; Brain; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Epilepsy | 2014 |
Parvalbumin immunoreactivity and expression of GABAA receptor subunits in the thalamus after experimental TBI.
Topics: Animals; Brain Injuries; Disease Models, Animal; Electroencephalography; Epilepsy; Functional Latera | 2014 |
A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.
Topics: Action Potentials; Animals; Animals, Newborn; Brain; Bumetanide; Convulsants; Disease Models, Animal | 2014 |
Autistic-like syndrome in mu opioid receptor null mice is relieved by facilitated mGluR4 activity.
Topics: Aggression; Anilides; Animals; Anxiety; Behavior, Animal; Brain; Child Development Disorders, Pervas | 2014 |
Expression of SOCSs and TLRs in the hippocampus of pentylenetetrazole kindling model.
Topics: Animals; Disease Models, Animal; Down-Regulation; Epilepsy; Hippocampus; Interleukin-1beta; Kindling | 2014 |
Characterization of a lamotrigine-resistant kindled model of epilepsy in mice: evaluation of drug resistance mechanisms.
Topics: Animals; Anticonvulsants; Calcium Channels; Carbamazepine; Disease Models, Animal; Drug Resistance; | 2014 |
Design, synthesis and pharmacological evaluation of N3 aryl/ heteroaryl substituted 2-((benzyloxy and phenylthio) methyl) 6,7- dimethoxyquinazolin-4(3H)-ones as potential anticonvulsant agents.
Topics: Alanine Transaminase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 2014 |
Nitric oxide mediates the anticonvulsant effects of thalidomide on pentylenetetrazole-induced clonic seizures in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitor | 2014 |
Proconvulsant effects of estriol, the third estrogen, in the mouse PTZ-kindling model.
Topics: Animals; Anticonvulsants; Clomiphene; Convulsants; Diazepam; Disease Models, Animal; Estriol; Female | 2014 |
Anticonvulsive effect of nonimidazole histamine H3 receptor antagonists.
Topics: Algorithms; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationshi | 2014 |
A synthetic bioisoster of trimethadione and phenytoin elicits anticonvulsant effect, protects the brain oxidative damage produced by seizures and exerts antidepressant action in mice.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Brain Injuries; Disease Models, Animal; Flunitrazep | 2014 |
Effect of quercetin and rutin in some acute seizure models in mice.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Ther | 2014 |
Dynamic expression patterns of ATF3 and p53 in the hippocampus of a pentylenetetrazole-induced kindling model.
Topics: Activating Transcription Factor 3; Animals; Behavior, Animal; Disease Models, Animal; Hippocampus; I | 2014 |
Inhibitor effect of dexketoprofen in rat model of pentylenetetrazol-induced seizures.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Convulsants; Disease Models, Animal; Electroenceph | 2015 |
Identification of marine neuroactive molecules in behaviour-based screens in the larval zebrafish.
Topics: Animals; Anticonvulsants; Behavior, Animal; Biological Products; Disease Models, Animal; Epilepsy; F | 2014 |
Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models.
Topics: Acute Disease; Amino Acids, Dicarboxylic; Animals; Brain; Central Nervous System Agents; Chronic Dis | 2014 |
Proconvulsant effects of tramadol and morphine on pentylenetetrazol-induced seizures in adult rats using different routes of administration.
Topics: Analgesics; Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Adm | 2014 |
Plurality of anxiety and depression alteration mechanism by oleanolic acid.
Topics: alpha-Methyltyrosine; Animals; Anti-Anxiety Agents; Antidepressive Agents; Brain; Brain-Derived Neur | 2014 |
Evaluation of anticonvulsant activity of novel pyrrolidin-2-one derivatives.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Electroshock; Ligands; Male; Mic | 2014 |
The effects of coenzyme Q10 on seizures in mice: the involvement of nitric oxide.
Topics: Animals; Arginine; Brain; Disease Models, Animal; Electroshock; Epilepsy, Tonic-Clonic; Guanidines; | 2014 |
Albumin nanoparticles for the delivery of gabapentin: preparation, characterization and pharmacodynamic studies.
Topics: Amines; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug C | 2014 |
Ultrasound-assisted synthesis, anticonvulsant activity, and docking study of indole-appended thiazolidin-4-ones.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Drug Design; Electroshock; Indol | 2014 |
Increased expression of GAP43 in interneurons in a rat model of experimental polymicrogyria.
Topics: Animals; Animals, Newborn; Brain; Disease Models, Animal; Female; GAP-43 Protein; Ibotenic Acid; Int | 2015 |
Pharmacoproteomics-based reconstruction of in vivo P-glycoprotein function at blood-brain barrier and brain distribution of substrate verapamil in pentylenetetrazole-kindled epilepsy, spontaneous epilepsy, and phenytoin treatment models.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barri | 2014 |
Synthesis and anticonvulsant activity of novel purine derivatives.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Mice; Motor Activity; Pentylenetetra | 2014 |
Normotopic cortex is the major contributor to epilepsy in experimental double cortex.
Topics: Animals; Bicuculline; Cerebral Cortex; Classical Lissencephalies and Subcortical Band Heterotopias; | 2014 |
Anticonvulsant and behavioral effects of muscimol in immature rats.
Topics: Age Factors; Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Dr | 2014 |
Curcumin supplementation improves mitochondrial and behavioral deficits in experimental model of chronic epilepsy.
Topics: Animals; Convulsants; Curcumin; Disease Models, Animal; Electron Transport Complex IV; Epilepsy; Kin | 2014 |
Zebrafish bioassay-guided microfractionation identifies anticonvulsant steroid glycosides from the Philippine medicinal plant Solanum torvum.
Topics: Animals; Anticonvulsants; Biological Assay; Chemical Fractionation; Chromatography, High Pressure Li | 2014 |
Synthesis, physicochemical, and anticonvulsant properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and its 3-methyl analog.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug | 2014 |
Novel fluorinated pyrrolo[1,2-a]pyrazine-2,6-dione derivatives: synthesis and anticonvulsant evaluation in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Ep | 2014 |
Effects of intravenous human umbilical cord blood mesenchymal stem cell therapy versus gabapentin in pentylenetetrazole-induced chronic epilepsy in rats.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Epilepsy; Female; Gabapentin; | 2014 |
Effects of D-penicillamine on pentylenetetrazole-induced seizures in mice: involvement of nitric oxide/NMDA pathways.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Male; Mice; N-Methylaspartate; Nitric | 2014 |
A single episode of juvenile status epilepticus reduces the threshold to adult seizures in a stimulus-specific way.
Topics: Animals; Animals, Newborn; Convulsants; Disease Models, Animal; Disease Progression; Female; Male; M | 2014 |
Potential mechanisms involved in the anticonvulsant effect of walnut extract on pentylenetetrazole-induced seizure.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug S | 2014 |
Synthesis, anticonvulsant properties, and SAR analysis of differently substituted pyrrolidine-2,5-diones and piperidine-2,6-diones.
Topics: Animals; Anticonvulsants; Cell Death; Disease Models, Animal; Drug Design; Electric Stimulation; Hip | 2014 |
Design, synthesis, and biological evaluation of hydrazone incorporated 1,2,4-triazines as anticonvulsant agents.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Binding Sites; Catalytic Domain; Computer-Ai | 2014 |
Ozone protective effects against PTZ-induced generalized seizures are mediated by reestablishment of cellular redox balance and A1 adenosine receptors.
Topics: Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Antioxidants; Brain; Disease Models, An | 2015 |
'Neonatal' Nav1.2 reduces neuronal excitability and affects seizure susceptibility and behaviour.
Topics: Action Potentials; Alternative Splicing; Animals; Animals, Newborn; Behavior, Animal; Brain; Disease | 2015 |
Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures.
Topics: Animals; Convulsants; Disease Models, Animal; Disease Susceptibility; Electroshock; Female; Fever; M | 2014 |
Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Convulsants; Diet, High-Fat; Disease Models, Anima | 2014 |
Anticonvulsant activity of the ethanolic extract of Punica granatum L. seed.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Lythra | 2015 |
Potential roles of the RGMa-FAK-Ras pathway in hippocampal mossy fiber sprouting in the pentylenetetrazole kindling model.
Topics: Animals; Behavior, Animal; CA3 Region, Hippocampal; Disease Models, Animal; Epilepsy, Temporal Lobe; | 2015 |
Towards real-time detection of seizures in awake rats with GPU-accelerated diffuse optical tomography.
Topics: Algorithms; Animals; Brain; Cerebrovascular Circulation; Computer Graphics; Computer Simulation; Dis | 2015 |
Involvement of PPAR receptors in the anticonvulsant effects of a cannabinoid agonist, WIN 55,212-2.
Topics: Anilides; Animals; Anticonvulsants; Benzoxazines; Cannabinoid Receptor Antagonists; Disease Models, | 2015 |
Involvement of the nitrergic system in the proconvulsant effect of social isolation stress in male mice.
Topics: Animals; Arginine; Convulsants; Disease Models, Animal; Enzyme Inhibitors; Hippocampus; Male; Mice; | 2014 |
An antagonist of calcium permeable AMPA receptors, IEM1460: Anticonvulsant action in immature rats?
Topics: Adamantane; Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Dru | 2015 |
Effects of linoleic acid on generalized convulsive and nonconvulsive epileptic seizures.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Epilepsy, Tonic-Clonic; | 2014 |
Age-dependent long-term structural and functional effects of early-life seizures: evidence for a hippocampal critical period influencing plasticity in adulthood.
Topics: Animals; Animals, Newborn; Atrophy; Corpus Callosum; Diffusion Tensor Imaging; Disease Models, Anima | 2015 |
Can pentylenetetrazole and maximal electroshock rodent seizure models quantitatively predict antiepileptic efficacy in humans?
Topics: Animals; Anticonvulsants; Convulsants; Databases, Bibliographic; Disease Models, Animal; Electroshoc | 2015 |
Pentylenetetrazol-induced seizure-like behavior and neural hyperactivity in the medicinal leech.
Topics: Action Potentials; Analysis of Variance; Animals; Anticonvulsants; Convulsants; Disease Models, Anim | 2015 |
Effect of ACE inhibitors and AT1 receptor antagonists on pentylenetetrazole-induced convulsions in mice.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Anticonv | 2015 |
Anxiolytic and antidepressive effects of electric stimulation of the paleocerebellar cortex in pentylenetetrazol kindled rats.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Biophysics; Cerebellar Cortex; Convulsants; Dis | 2014 |
Fluvoxamine alleviates seizure activity and downregulates hippocampal GAP-43 expression in pentylenetetrazole-kindled mice: role of 5-HT3 receptors.
Topics: Animals; Anticonvulsants; Cell Death; Disease Models, Animal; Fluvoxamine; GAP-43 Protein; Hippocamp | 2015 |
Anticonvulsant effect of Cicer arietinum seed in animal models of epilepsy: introduction of an active molecule with novel chemical structure.
Topics: Animals; Anticonvulsants; Cicer; Disease Models, Animal; Electroshock; Epilepsy; Male; Mice; Pentyle | 2015 |
Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; | 2015 |
Maximal electroshock-induced seizures are able to induce Homer1a mRNA expression but not pentylenetetrazole-induced seizures.
Topics: Animals; Anticonvulsants; Carrier Proteins; Convulsants; Disease Models, Animal; Electroshock; Homer | 2015 |
Valproate-induced neurodevelopmental deficits in Xenopus laevis tadpoles.
Topics: Animals; Animals, Genetically Modified; Anticonvulsants; Avoidance Learning; Convulsants; Dendrites; | 2015 |
Cortical alterations in a model for absence epilepsy and febrile seizures: in vivo findings in mice carrying a human GABA(A)R gamma2 subunit mutation.
Topics: Action Potentials; Animals; Cerebral Cortex; Convulsants; Disease Models, Animal; Epilepsy, Absence; | 2015 |
Constipation enhances the propensity to seizure in pentylenetetrazole-induced seizure models of mice.
Topics: Animals; Antidiarrheals; Constipation; Convulsants; Disease Models, Animal; Drug Interactions; Gastr | 2015 |
α-Spinasterol, a TRPV1 receptor antagonist, elevates the seizure threshold in three acute seizure tests in mice.
Topics: Animals; Anticonvulsants; Body Temperature; Disease Models, Animal; Dose-Response Relationship, Drug | 2015 |
New benzo[d]thiazol-2-yl-aminoacetamides as potential anticonvulsants: synthesis, activity and prediction of molecular properties.
Topics: Acetamides; Animals; Anticonvulsants; Benzothiazoles; Carbamazepine; Computer Simulation; Disease Mo | 2015 |
Down-regulation of Homer1b/c protects against chemically induced seizures through inhibition of mTOR signaling.
Topics: Animals; Behavior, Animal; Carrier Proteins; Disease Models, Animal; Down-Regulation; Glycine; Hippo | 2015 |
Different preparations, doses, and treatment regimens of cyclosporine A cause adverse effects but no robust changes in seizure thresholds in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Temperature; Body Weight; Convulsants; Cyclosp | 2015 |
Design, synthesis and biological evaluation of new hybrid anticonvulsants derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide derivatives.
Topics: Amides; Animals; Anticonvulsants; Benzylamines; Convulsants; Disease Models, Animal; Dose-Response R | 2015 |
Effects of modafinil on pentylenetetrazol-induced convulsive epilepsy.
Topics: Animals; Anticonvulsants; Benzhydryl Compounds; Brain; Disease Models, Animal; Dose-Response Relatio | 2015 |
Anticonvulsant effects of mefloquine on generalized tonic-clonic seizures induced by two acute models in rats.
Topics: Acute Disease; Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, | 2015 |
Peroxisome proliferator-activated receptor-γ agonist inhibits the mammalian target of rapamycin signaling pathway and has a protective effect in a rat model of status epilepticus.
Topics: Animals; CA3 Region, Hippocampal; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunoh | 2015 |
Synthesis, Biological Activity, and Docking Study of Novel Isatin Coupled Thiazolidin-4-one Derivatives as Anticonvulsants.
Topics: Animals; Anticonvulsants; Behavior, Animal; Binding Sites; Computer-Aided Design; Disease Models, An | 2015 |
Contrasting effects of Na+, K+-ATPase activation on seizure activity in acute versus chronic models.
Topics: Animals; Antibodies; Anticonvulsants; Brain Waves; Convulsants; Disease Models, Animal; Electroencep | 2015 |
Grouping Pentylenetetrazol-Induced Epileptic Rats According to Memory Impairment and MicroRNA Expression Profiles in the Hippocampus.
Topics: Animals; Cluster Analysis; Computational Biology; Databases, Nucleic Acid; Disease Models, Animal; E | 2015 |
Effects of JIP3 on epileptic seizures: Evidence from temporal lobe epilepsy patients, kainic-induced acute seizures and pentylenetetrazole-induced kindled seizures.
Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Animals; Apoptosis; CA3 Region, Hippocampal | 2015 |
Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Docosahexaenoic Acids; Dose-Response Relationship, | 2015 |
Vitis labrusca leaf extract prevents pentylenetetrazol-induced oxidative damage but not seizures in rats.
Topics: Animals; Anticonvulsants; Antioxidants; Cerebellum; Cerebral Cortex; Disease Models, Animal; Hippoca | 2015 |
Anticonvulsant properties of an oral ketone ester in a pentylenetetrazole-model of seizure.
Topics: Acetoacetates; Administration, Oral; Analysis of Variance; Animals; Anticonvulsants; Butylene Glycol | 2015 |
Synthesis and Anticonvulsant Activity of Substituted-1,3-diazaspiro[4.5]decan-4-ones.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Disease Models, Animal; Drug Design; Electroshock | 2015 |
Rapamycin suppresses PTZ-induced seizures at different developmental stages of zebrafish.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Larva; Mechanistic Target of Rapamyci | 2015 |
Synthesis and Anticonvulsant Activity Evaluation of 4-Phenyl-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one and Its Derivatives.
Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Brain; Disease Models, Animal; Drug Design; | 2015 |
proBDNF and p75NTR Control Excitability and Persistent Firing of Cortical Pyramidal Neurons.
Topics: Action Potentials; Aminoquinolines; Animals; Brain-Derived Neurotrophic Factor; Carbachol; Cells, Cu | 2015 |
Bioactive C21 Steroidal Glycosides from the Roots of Cynanchum otophyllum That Suppress the Seizure-like Locomotor Activity of Zebrafish Caused by Pentylenetetrazole.
Topics: Animals; Cynanchum; Disease Models, Animal; Drugs, Chinese Herbal; Glycosides; Molecular Structure; | 2015 |
Anticonvulsant properties of Euterpe oleracea in mice.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Disease Models, Animal; Euterpe; Male; Mice; Oxidativ | 2015 |
Protective effect on phenytoin-induced cognition deficit in pentylenetetrazol kindled mice: A repertoire of Glycyrrhiza glabra flavonoid antioxidants.
Topics: Acetates; Animals; Anticonvulsants; Antioxidants; Behavior, Animal; Brain; Cognition; Cognition Diso | 2016 |
N-[(2,6-Dimethylphenoxy)alkyl]aminoalkanols-their physicochemical and anticonvulsant properties.
Topics: Animals; Anticonvulsants; Chemistry Techniques, Synthetic; Disease Models, Animal; Drug Evaluation, | 2015 |
A novel GABA(A) alpha 5 receptor inhibitor with therapeutic potential.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Blood-Brain Barrier; Capillary Permeabi | 2015 |
Quetiapine attenuates cognitive impairment and decreases seizure susceptibility possibly through promoting myelin development in a rat model of malformations of cortical development.
Topics: Animals; Animals, Newborn; Anticonvulsants; Cerebral Cortex; Cognition Disorders; Corpus Callosum; D | 2015 |
Effect of sparteine on status epilepticus induced in rats by pentylenetetrazole, pilocarpine and kainic acid.
Topics: Animals; Anticonvulsants; Brain Waves; Convulsants; Disease Models, Animal; Electroencephalography; | 2015 |
Decreased expression of hippocampal Na⁺/Ca²⁺ exchanger isoform-1 by pentylenetetrazole kindling in mice.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Down-Regulation; Hippocampus; Homeodomain Proteins | 2015 |
Reversal of P-glycoprotein overexpression by Ginkgo biloba extract in the brains of pentylenetetrazole-kindled and phenytoin-treated mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Caspase 3; Disease Models, | 2015 |
Increased sensitivity to kindling in mice lacking TSP1.
Topics: Animals; Calcium Channels; Disease Models, Animal; Kindling, Neurologic; Male; Mice; Mice, Transgeni | 2015 |
Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats.
Topics: Adenosine; Animals; Anticonvulsants; Diet, Ketogenic; Disease Models, Animal; Disease Progression; D | 2015 |
Insulin growth factor-1 (IGF-1) enhances hippocampal excitatory and seizure activity through IGF-1 receptor-mediated mechanisms in the epileptic brain.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Brain Waves; Case-Control Studies; Disease Models, Anim | 2015 |
Traumatic brain injury accelerates kindling epileptogenesis in rats.
Topics: Amygdala; Animals; Brain Injuries, Traumatic; Cerebral Cortex; Convulsants; Disease Models, Animal; | 2016 |
Metallothionein expression in the rat brain following KA and PTZ treatment.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Metallothionein; Oxidative Stre | 2015 |
Discovery of benzothiazine derivatives as novel, orally-active anti-epileptic drug candidates with broad anticonvulsant effect.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, | 2015 |
Sulforaphane is anticonvulsant and improves mitochondrial function.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electron Transport Complex I; Electro | 2015 |
Palmitoylethanolamide attenuates PTZ-induced seizures through CB1 and CB2 receptors.
Topics: Amides; Animals; Anticonvulsants; Disease Models, Animal; Ethanolamines; Kindling, Neurologic; Male; | 2015 |
Epileptogenic effects of NMDAR antibodies in a passive transfer mouse model.
Topics: Animals; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Autoantibodies; Brain; Convulsants; Diseas | 2015 |
Plic-1, a new target in repressing epileptic seizure by regulation of GABAAR function in patients and a rat model of epilepsy.
Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Animals; Anticonvulsants; Autophagy-Related | 2015 |
Effects of melatonin and theanine administration on pentylenetetrazole-induced seizures and brain tissue oxidative damage in ovariectomized rats.
Topics: Animals; Antioxidants; Biological Availability; Brain; Central Nervous System Depressants; Disease M | 2015 |
Blockade of T-type calcium channels prevents tonic-clonic seizures in a maximal electroshock seizure model.
Topics: Analysis of Variance; Animals; Benzeneacetamides; Brain; Calcium Channel Blockers; Calcium Channels, | 2016 |
Design and Synthesis of Novel Phenylpiperazine Derivatives as Potential Anticonvulsant Agents.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Drug Design; Male; Mice; Molecular Structur | 2015 |
Interactions between an antidepressant reboxetine and four classic antiepileptic drugs in the mouse model of myoclonic seizures.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Avoidance Learning; Clonazepam; Disease Models, Ani | 2015 |
Morphine modulates the effects of histamine H1 and H3 receptors on seizure susceptibility in pentylenetetrazole-induced seizure model of mice.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Histamine | 2015 |
Synthesis of 2,6-dicarbethoxy-3,5-diaryltetrahydro-1,4-thiazine-1,1-dioxide derivatives as potent anticonvulsant agents.
Topics: Animals; Anticonvulsants; Crystallography, X-Ray; Cyclic S-Oxides; Disease Models, Animal; Dose-Resp | 2015 |
Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage.
Topics: Analysis of Variance; Animals; Brain Injuries; Cell Survival; Disease Models, Animal; Excitatory Ami | 2016 |
Anticonvulsant activity, crystal structures, and preliminary safety evaluation of N-trans-cinnamoyl derivatives of selected (un)modified aminoalkanols.
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Drug Evalu | 2016 |
Mechanism of action of antiepileptic ceramide from Red Sea soft coral Sarcophyton auritum.
Topics: Allosteric Regulation; Animals; Anthozoa; Anticonvulsants; Binding Sites; Ceramides; Disease Models, | 2015 |
Disruption of polycystin-L causes hippocampal and thalamocortical hyperexcitability.
Topics: Animals; Calcium Channels; Cerebral Cortex; Cilia; Cyclic AMP; Cyclic AMP Response Element-Binding P | 2016 |
Lipopolysaccharide preconditioning prevents acceleration of kindling epileptogenesis induced by traumatic brain injury.
Topics: Analysis of Variance; Animals; Brain Injuries; Convulsants; Disease Models, Animal; Dose-Response Re | 2015 |
Possible involvement of nitrergic and opioidergic systems in the modulatory effect of acute chloroquine treatment on pentylenetetrazol induced convulsions in mice.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anticonvulsants; Arginine; Chloroquine; Disease M | 2016 |
Modulation of brain glutamate dehydrogenase as a tool for controlling seizures.
Topics: Animals; Anticonvulsants; Brain; Deamination; Diazepam; Disease Models, Animal; Enzyme Inhibitors; G | 2015 |
Optogenetic activation of superior colliculus neurons suppresses seizures originating in diverse brain networks.
Topics: 4-Butyrolactone; Acoustic Stimulation; Animals; Brain Stem; Disease Models, Animal; Electrocorticogr | 2016 |
Hippocampal Transcriptome Profile of Persistent Memory Rescue in a Mouse Model of THRA1 Mutation-Mediated Resistance to Thyroid Hormone.
Topics: Animals; CA1 Region, Hippocampal; Dendritic Spines; Disease Models, Animal; Excitatory Postsynaptic | 2016 |
New hybrid molecules with anticonvulsant and antinociceptive activity derived from 3-methyl- or 3,3-dimethyl-1-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]pyrrolidine-2,5-diones.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Elec | 2016 |
Different calorie restriction treatments have similar anti-seizure efficacy.
Topics: Analysis of Variance; Animals; Anticonvulsants; Blood Glucose; Body Weight; Butylene Glycols; Calori | 2016 |
The Influence of Vagus Nerve and Spinal Cord Stimulation on the Ictal Fast Ripple Activity in a Spike-and-Wave Rat Model of Seizures.
Topics: Animals; Biophysics; Brain Waves; Disease Models, Animal; Electroencephalography; Male; Pentylenetet | 2016 |
Increased Epileptiform EEG Activity and Decreased Seizure Threshold in Arctic APP Transgenic Mouse Model of Alzheimer's Disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brai | 2016 |
NMDA receptor antagonists attenuate the proconvulsant effect of juvenile social isolation in male mice.
Topics: Age Factors; Animals; Animals, Newborn; Disease Models, Animal; Dizocilpine Maleate; Dose-Response R | 2016 |
A role for ATP-sensitive potassium channels in the anticonvulsant effects of triamterene in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Convulsants; Diazoxide; Disease Models, Animal; Dose | 2016 |
The α4β2 nicotinic acetylcholine receptor modulates autism-like behavioral and motor abnormalities in pentylenetetrazol-kindled mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Autistic Disorder; Behavior, Animal; Convulsants; Disease Mod | 2016 |
The interaction between morphine and propranolol in chemical and electrical seizure models of mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administrat | 2016 |
Antiepileptogenic effects of borneol in pentylenetetrazole-induced kindling in mice.
Topics: Animals; Anticonvulsants; Brain; Camphanes; Catalase; Convulsants; Disease Models, Animal; Epilepsy; | 2016 |
Cerebral Cortical Circuitry Formation Requires Functional Glycine Receptors.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Immunohistochemistry; Male; Membrane Potentials; M | 2017 |
Anticonvulsant Effects of Combined Treatment with Citicoline and Valproate on the Model of Acute Generalized Convulsions Induced by Pentylenetetrazole in Wistar Rats.
Topics: Animals; Anticonvulsants; Cytidine Diphosphate Choline; Disease Models, Animal; Drug Therapy, Combin | 2016 |
The bumetanide prodrug BUM5, but not bumetanide, potentiates the antiseizure effect of phenobarbital in adult epileptic mice.
Topics: Animals; Anticonvulsants; Bumetanide; Convulsants; Disease Models, Animal; Dose-Response Relationshi | 2016 |
Pharmacological evaluation of novel 1-[4-(4-benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-phenyl]-3-phenyl-urea as potent anticonvulsant and antidepressant agent.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Antidepressive Agents; Disease Models, Animal; E | 2016 |
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagoni | 2016 |
Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives as Potential Anticonvulsant Agents.
Topics: Animals; Anticonvulsants; Benzothiazoles; Convulsants; Disease Models, Animal; Drug Design; Electros | 2016 |
Indomethacin treatment prior to pentylenetetrazole-induced seizures downregulates the expression of il1b and cox2 and decreases seizure-like behavior in zebrafish larvae.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclooxygenase 2; Disease Models, Animal; D | 2016 |
NADPH oxidase activation is required for pentylenetetrazole kindling-induced hippocampal autophagy.
Topics: Animals; Autophagy; Brain Mapping; Disease Models, Animal; Epilepsy; Hippocampus; Humans; Kindling, | 2016 |
Synthesis, and anticonvulsant activity of new amides derived from 3-methyl- or 3-ethyl-3-methyl-2,5-dioxo-pyrrolidin-1-yl-acetic acids.
Topics: Amides; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electros | 2016 |
Continuous bilateral infusion of vigabatrin into the subthalamic nucleus: Effects on seizure threshold and GABA metabolism in two rat models.
Topics: Animals; Basal Ganglia; Disease Models, Animal; Electric Stimulation; Female; gamma-Aminobutyric Aci | 2016 |
Synthesis of Novel 8-alkylamino-5, 6-dihydro-4H-benzo[f] [1,2,4]triazolo [4,3-a]azepines as Anticonvulsant Agents.
Topics: Animals; Anticonvulsants; Azepines; Convulsants; Disease Models, Animal; Dose-Response Relationship, | 2016 |
Anticonvulsant activity of melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, in mice.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Ele | 2016 |
Anxiety-related behavioral responses of pentylenetetrazole-treated zebrafish larvae to light-dark transitions.
Topics: Animals; Anxiety; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrocortisone; Larva; L | 2016 |
New partners and phosphorylation sites of focal adhesion kinase identified by mass spectrometry.
Topics: Animals; Animals, Newborn; Binding Sites; Brain; Catalytic Domain; Chromatography, Liquid; Disease M | 2016 |
Prediction of seizure incidence probability in PTZ model of kindling through spatial learning ability in male and female rats.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy; Female; Kindling, Neurologic; Male; Maze Lea | 2016 |
Nicotine increases eclampsia-like seizure threshold and attenuates microglial activity in rat hippocampus through the α7 nicotinic acetylcholine receptor.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Astrocytes; Blood Pressure; CA1 Region, Hippocampa | 2016 |
Anticonvulsant Activity of Enantiomeric N-trans-Cinnamoyl Derivatives of 2-Aminopropan-1-ols and 2-Aminobutan-1-ols.
Topics: Animals; Anticonvulsants; Chemistry Techniques, Synthetic; Crystallography, X-Ray; Cytochrome P-450 | 2016 |
Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice.
Topics: Animals; Brain; Convulsants; Disease Models, Animal; Disease Susceptibility; Mice; Mice, Inbred C57B | 2016 |
Neonatal seizures induced by pentylenetetrazol or kainic acid disrupt primary cilia growth on developing mouse cortical neurons.
Topics: Age Factors; Animals; Animals, Newborn; Cerebral Cortex; Convulsants; Disease Models, Animal; Dose-R | 2016 |
Oxytocin is involved in the proconvulsant effects of Sildenafil: Possible role of CREB.
Topics: Animals; CREB-Binding Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Hippocampus | 2016 |
Increased susceptibility to pentylenetetrazol following survival of cerebral malaria in mice.
Topics: Animals; Body Weight; Convulsants; Disease Models, Animal; Disease Susceptibility; Electroencephalog | 2016 |
5-Hydroxytryptophan, a precursor for serotonin synthesis, reduces seizure-induced respiratory arrest.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Brain Stem; Disease Models, Animal; Dose-Respons | 2016 |
Design, synthesis, anticonvulsant, and antiarrhythmic properties of novel N-Mannich base and amide derivatives of β-tetralinohydantoin.
Topics: Amides; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Disease Models, Animal; Drug Design; Elect | 2016 |
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment.
Topics: Animals; Anticonvulsants; Brain; Callithrix; Carbamazepine; Chronic Disease; Disease Models, Animal; | 2016 |
Evidence in support of using a neurochemistry approach to identify therapy for both epilepsy and associated depression.
Topics: Animals; Anticonvulsants; Brain; Depression; Depressive Disorder; Disease Models, Animal; Dopamine; | 2016 |
Inhibitor effect of paricalcitol in rat model of pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Antioxidants; Behavior, Animal; Biomarkers; Brain; Brain Waves; Disease Mo | 2016 |
Analysis of the Expressions of TrkB and GLT-1 in Brain Tissues on a Rat Pentylenetetrazol Kindling Model of Chronic Epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Transporter 2; Hippoca | 2016 |
MicroRNA-328a regulates water maze performance in PTZ-kindled rats.
Topics: Amyloid Precursor Protein Secretases; Animals; Antagomirs; Aspartic Acid Endopeptidases; Disease Mod | 2016 |
15q13.3 homozygous knockout mouse model display epilepsy-, autism- and schizophrenia-related phenotypes.
Topics: Animals; Auditory Perceptual Disorders; Autistic Disorder; Behavior, Animal; Chromosome Deletion; Ch | 2016 |
Behavioral and genotoxic evaluation of rosmarinic and caffeic acid in acute seizure models induced by pentylenetetrazole and pilocarpine in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Caffeic Acids; Cinnamates; Comet Assay; Depsides; | 2016 |
The modulatory effect of nitric oxide in pro- and anti-convulsive effects of vasopressin in PTZ-induced seizures threshold in mice.
Topics: Animals; Anticonvulsants; Antidiuretic Hormone Receptor Antagonists; Arginine; Arginine Vasopressin; | 2016 |
The effect of leptin, ghrelin, and neuropeptide-Y on serum Tnf-Α, Il-1β, Il-6, Fgf-2, galanin levels and oxidative stress in an experimental generalized convulsive seizure model.
Topics: Animals; Cytokines; Disease Models, Animal; Fibroblast Growth Factor 2; Galanin; Ghrelin; Interleuki | 2017 |
Ferulic acid exhibits antiepileptogenic effect and prevents oxidative stress and cognitive impairment in the kindling model of epilepsy.
Topics: Animals; Anticonvulsants; Antioxidants; Avoidance Learning; Cognitive Dysfunction; Coumaric Acids; D | 2017 |
Nicotinic and muscarinic cholinergic receptors are recruited by acetylcholine-mediated neurotransmission within the locus coeruleus during the organisation of post-ictal antinociception.
Topics: Acetylcholine; Animals; Atropine; Disease Models, Animal; Dose-Response Relationship, Drug; Locus Co | 2016 |
In silico Screening and Evaluation of the Anticonvulsant Activity of Docosahexaenoic Acid-Like Molecules in Experimental Models of Seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Docosahexaenoic Acids; Drug Design; Electroshock; | 2017 |
Resveratrol lacks protective activity against acute seizures in mouse models.
Topics: Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; El | 2016 |
Antinociceptive and anticonvulsant effects of the monoterpene linalool oxide.
Topics: Acetic Acid; Acyclic Monoterpenes; Analgesics; Animals; Anticonvulsants; Behavior, Animal; Cyclohexa | 2017 |
Structure-activity relationship for the anticonvulsant effects of organic solvents.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Exc | 2016 |
Anticonvulsant and neuroprotective effects of apelin-13 on pentylenetetrazole-induced seizures in male rats.
Topics: Animals; Anticonvulsants; Apelin Receptors; Apoptosis; Astrocytes; Brain; Disease Models, Animal; Gl | 2016 |
Octreotide ameliorates inflammation and apoptosis in acute and kindled murine PTZ paradigms.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Apoptosis; Caspase 3; Cerebral Cortex; Cytoprote | 2017 |
Anticonvulsant activity of an active fraction extracted from Crinum jagus L. (Amaryllidaceae), and its possible effects on fully kindled seizures, depression-like behaviour and oxidative stress in experimental rodent models.
Topics: Animals; Anticonvulsants; Crinum; Depression; Disease Models, Animal; Kindling, Neurologic; Male; Mi | 2016 |
EGAR, A Food Protein-Derived Tetrapeptide, Reduces Seizure Activity in Pentylenetetrazole-Induced Epilepsy Models Through α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionate Receptors.
Topics: Animals; Anticonvulsants; CA1 Region, Hippocampal; Cells, Cultured; Disease Models, Animal; Epilepsy | 2017 |
Crocin Attenuates Kindling Development and Associated Cognitive Impairments in Mice via Inhibiting Reactive Oxygen Species-Mediated NF-κB Activation.
Topics: Animals; Carotenoids; Cognition Disorders; Cognitive Dysfunction; Crocus; Disease Models, Animal; Do | 2017 |
Changes in vagus nerve activity associated with ictal tachycardia in pigs.
Topics: Animals; Blood Pressure; Carotid Arteries; Disease Models, Animal; Electrocardiography; Electrocorti | 2016 |
Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism.
Topics: Animals; Anticonvulsants; Benzothiazoles; Calcium Channels; Cerebellum; Convulsants; Disease Models, | 2016 |
Levosimendan exerts anticonvulsant properties against PTZ-induced seizures in mice through activation of nNOS/NO pathway: Role for K
Topics: Animals; Anticonvulsants; Disease Models, Animal; Enzyme Activation; Hydrazones; KATP Channels; Male | 2017 |
AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets.
Topics: Aggrecans; Animals; Anticonvulsants; Behavior, Animal; Chondroitin ABC Lyase; Disease Models, Animal | 2016 |
Simple N,N-dimethyl phenylsulfonamides show potent anticonvulsant effect in two standard epilepsy models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Ep | 2017 |
Remarkable alterations of Nav1.6 in reactive astrogliosis during epileptogenesis.
Topics: Animals; Astrocytes; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Huma | 2016 |
Gastrodin Attenuates Pentylenetetrazole-Induced Seizures by Modulating the Mitogen-Activated Protein Kinase-Associated Inflammatory Responses in Mice.
Topics: Animals; Anti-Inflammatory Agents; Benzyl Alcohols; Convulsants; CREB-Binding Protein; Disease Model | 2017 |
Assessment of luteolin isolated from Eclipta alba leaves in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Biomarkers; Brain; Disease Models, Animal; Dose-Response Relationship, Dru | 2017 |
The effects of linalool on the excitability of central neurons of snail Caucasotachea atrolabiata.
Topics: Action Potentials; Acyclic Monoterpenes; Animals; Anticonvulsants; Calcium Channel Blockers; Calcium | 2017 |
Effects of the synthetic neurosteroid ganaxolone on seizure activity and behavioral deficits in an Angelman syndrome mouse model.
Topics: Angelman Syndrome; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Disease Models, Animal; F | 2017 |
The PRRT2 knockout mouse recapitulates the neurological diseases associated with PRRT2 mutations.
Topics: Animals; Animals, Newborn; Brain; Cognition; Disease Models, Animal; Female; Male; Membrane Proteins | 2017 |
The effect of sertraline and 8-OH-DPAT on the PTZ_induced seizure threshold: Role of the nitrergic system.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Convulsants; Disease Models, | 2017 |
Manipulation of Epileptiform Electrocorticograms (ECoGs) and Sleep in Rats and Mice by Acupuncture.
Topics: Animals; Disease Models, Animal; Electroacupuncture; Electrocorticography; Electromyography; Epileps | 2016 |
Adjuvant quercetin therapy for combined treatment of epilepsy and comorbid depression.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Combined Modality Therapy; Convulsants; Depressio | 2017 |
Sodium selenate treatment improves symptoms and seizure susceptibility in a malin-deficient mouse model of Lafora disease.
Topics: Animals; Antioxidants; Anxiety; Convulsants; Disease Models, Animal; Dual-Specificity Phosphatases; | 2017 |
Effects of oleuropein on pentylenetetrazol-induced seizures in mice: involvement of opioidergic and nitrergic systems.
Topics: Animals; Biological Products; Disease Models, Animal; Dose-Response Relationship, Drug; Iridoid Gluc | 2017 |
Anticonvulsant effect of sodium cyclamate and propylparaben on pentylenetetrazol-induced seizures in zebrafish.
Topics: Animals; Anticonvulsants; Cyclamates; Disease Models, Animal; Parabens; Pentylenetetrazole; Preserva | 2017 |
4-Phenylbutyric acid and metformin decrease sensitivity to pentylenetetrazol-induced seizures in a malin knockout model of Lafora disease.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Disease Models, Animal; Dose-Response Relationship, Dr | 2017 |
Analgesic, antiallodynic, and anticonvulsant activity of novel hybrid molecules derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide in animal models of pain and epilepsy.
Topics: Amides; Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Male; Mice; Motor Ac | 2017 |
Obestatin improves oxidative brain damage and memory dysfunction in rats induced with an epileptic seizure.
Topics: Animals; Antioxidants; Brain; Brain Injuries; Disease Models, Animal; Epilepsy; Ghrelin; Glutathione | 2017 |
Cellular responses to recurrent pentylenetetrazole-induced seizures in the adult zebrafish brain.
Topics: Animals; Behavior, Animal; Brain; Convulsants; Disease Models, Animal; Epilepsy; Motor Activity; Pen | 2017 |
Antiseizure Effects of Ketogenic Diet on Seizures Induced with Pentylenetetrazole, 4-Aminopyridine and Strychnine in Wistar Rats.
Topics: 4-Aminopyridine; Animal Nutritional Physiological Phenomena; Animals; Biomarkers; Blood Glucose; Die | 2017 |
Synergistic anticonvulsant effects of pregabalin and amlodipine on acute seizure model of epilepsy in mice.
Topics: Amlodipine; Animals; Anticonvulsants; Disease Models, Animal; Drug Synergism; Drug Therapy, Combinat | 2017 |
Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Anticonvulsants; Blotting, Western; | 2008 |
Increase in antiepileptic efficacy during prolonged treatment with valproic acid: role of inhibition of histone deacetylases?
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Genera | 2008 |
Antiepileptic effect of electroacupuncture vs. vagus nerve stimulation in the rat thalamus.
Topics: Action Potentials; Acupuncture Points; Animals; Disease Models, Animal; Dose-Response Relationship, | 2008 |
Cyclin D1 in excitatory neurons of the adult brain enhances kainate-induced neurotoxicity.
Topics: Adult; Animals; Apoptosis; Convulsants; Cyclin D1; Disease Models, Animal; Epilepsy; Female; Hippoca | 2008 |
Anticonvulsant effect of BmK IT2, a sodium channel-specific neurotoxin, in rat models of epilepsy.
Topics: Action Potentials; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response | 2008 |
Vagus nerve stimulation suppresses generalized seizure activity and seizure-triggered postictal cardiac rhythm changes in rats.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Disease Models, Animal; Electrocardiography; Electroe | 2009 |
Anticonvulsant effect of a natural compound alpha,beta-epoxy-carvone and its action on the nerve excitability.
Topics: Action Potentials; Animals; Anticonvulsants; Convulsants; Cyclohexane Monoterpenes; Disease Models, | 2008 |
Anticonvulsant serotonergic and deep brain stimulation in anterior thalamus.
Topics: Analysis of Variance; Animals; Deep Brain Stimulation; Disease Models, Animal; Dose-Response Relatio | 2009 |
Dose-finding study with nicotine as a proconvulsant agent in PTZ-induced seizure model in mice.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Dru | 2008 |
Role of nitric oxide in the anticonvulsive effect of progesterone.
Topics: Analysis of Variance; Animals; Anticonvulsants; Arginine; Disease Models, Animal; Dose-Response Rela | 2008 |
Effect of metal chelating agents on pentylenetetrazole-induced seizure threshold in cholestatic mice.
Topics: Animals; Bile Ducts; Chelating Agents; Cholestasis; Disease Models, Animal; Dithizone; Ditiocarb; Do | 2009 |
Isobolographic and behavioral characterizations of interactions between vigabatrin and gabapentin in two experimental models of epilepsy.
Topics: Amines; Animals; Anticonvulsants; Behavior, Animal; Brain; Cyclohexanecarboxylic Acids; Disease Mode | 2008 |
Antiepileptic effects of quinine in the pentylenetetrazole model of seizure.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Male; Mice; Mice, Inbred BALB C; Moto | 2009 |
Involvement of the limbic basal ganglia in ethanol withdrawal convulsivity in mice is influenced by a chromosome 4 locus.
Topics: Alcohol Withdrawal Seizures; Analysis of Variance; Animals; Basal Ganglia; Chromosomes, Human, Pair | 2008 |
Developmental impact of a familial GABAA receptor epilepsy mutation.
Topics: Animals; Brain; Brain Chemistry; Convulsants; Disease Models, Animal; Epilepsy; gamma-Aminobutyric A | 2008 |
The neurosteroid environment in the hippocampus exerts bi-directional effects on seizure susceptibility in mice.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Alcohol-Induced Disorders, Nerv | 2008 |
The fruit essential oil of Pimpinella anisum L. (Umblliferae) induces neuronal hyperexcitability in snail partly through attenuation of after-hyperpolarization.
Topics: Action Potentials; Animals; Anticonvulsants; Calcium Channels; Convulsants; Disease Models, Animal; | 2008 |
Assessment of seizure susceptibility in pilocarpine epileptic and nonepileptic Wistar rats and of seizure reinduction with pentylenetetrazole and electroshock models.
Topics: Analysis of Variance; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Disease Suscept | 2009 |
Fenofibrate, a peroxisome proliferator-activated receptor-alpha agonist, exerts anticonvulsive properties.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Body Weight; Diet, Ketogenic; Disease Models, | 2009 |
Anticonvulsant effects of the BK-channel antagonist paxilline.
Topics: Analysis of Variance; Animals; Animals, Newborn; Cell Count; Disease Models, Animal; Dose-Response R | 2009 |
Swimming training prevents pentylenetetrazol-induced inhibition of Na+, K+-ATPase activity, seizures, and oxidative stress.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Weight; Catalase; Disease Models, Animal; Elec | 2009 |
Tolerance to the anticonvulsant effect of morphine in mice: blockage by ultra-low dose naltrexone.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Res | 2009 |
Effects of progesterone on total brain tissue adenosine deaminase activity in experimental epilepsy.
Topics: Adenosine; Adenosine Deaminase; Animals; Brain; Convulsants; Disease Models, Animal; Epilepsy; Femal | 2009 |
Antiepileptic activity of melatonin in guinea pigs with pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Brain; Central Nervous System Depressants; Convulsants; Disease Models, An | 2009 |
AMN 082, an agonist of mGluR7, exhibits mixed anti- and proconvulsant effects in developing rats.
Topics: Age Factors; Aging; Animals; Anticonvulsants; Benzhydryl Compounds; Disease Models, Animal; Dose-Res | 2008 |
A Drosophila systems model of pentylenetetrazole induced locomotor plasticity responsive to antiepileptic drugs.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drosophila; Epilepsy; Gene Expression Profiling; G | 2009 |
Paradoxical facilitation of pentylenetetrazole-induced convulsion susceptibility in mice lacking neuronal nitric oxide synthase.
Topics: Animals; Convulsants; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; | 2009 |
Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis.
Topics: Amines; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug I | 2009 |
Morphine dependence increases the response to a brief pentylenetetrazol administration in rat hippocampal CA1 in vitro.
Topics: Animals; Convulsants; Disease Models, Animal; Drug Interactions; Electric Stimulation; Evoked Potent | 2009 |
Synthesis of 2-substituted-6-(4H-1,2,4-triazol-4-yl)benzo[d]oxazoles as potential anticonvulsant agents.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzoxazoles; Carbamazepine; Disease Models, Animal; Ele | 2009 |
Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB(1) agonist ACEA in the pentylenetetrazole-induced seizure in mice.
Topics: Analysis of Variance; Animals; Animals, Inbred Strains; Anticonvulsants; Arachidonic Acids; Arginine | 2009 |
Pentylenetetrazole-induced seizures affect binding site densities for GABA, glutamate and adenosine receptors in the rat brain.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Convulsants; Disease Models, Animal; Epilepsy; | 2009 |
Single injection of a low dose of pentylenetetrazole leads to epileptogenesis in an animal model of cortical dysplasia.
Topics: Age Factors; Animals; Animals, Newborn; Convulsants; Disease Models, Animal; Electroencephalography; | 2009 |
Anticonvulsant and antiepileptic actions of 2-deoxy-D-glucose in epilepsy models.
Topics: Animals; Anticonvulsants; Deoxyglucose; Disease Models, Animal; Dose-Response Relationship, Drug; El | 2009 |
Cyclization of the semicarbazone template of aryl semicarbazones: synthesis and anticonvulsant activity of 4,5-diphenyl-2H-1,2,4-triazol-3(4H)-one.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Male; Mice; Pentylenetetrazole; Picr | 2009 |
Central action of Araucaria angustifolia seed lectin in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Rela | 2009 |
Hyperthermic seizures and hyperthermia in immature rats modify the subsequent pentylenetetrazole-induced seizures.
Topics: Animals; Animals, Newborn; Convulsants; Disease Models, Animal; Female; Fever; Male; Pentylenetetraz | 2009 |
The effects of group III mGluR ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Convulsants; Disease Models, Animal; Dose-Response Re | 2009 |
Proepileptic phenotype of SV2A-deficient mice is associated with reduced anticonvulsant efficacy of levetiracetam.
Topics: Amygdala; Animals; Anticonvulsants; Binding Sites; Brain; Disease Models, Animal; Electroshock; Epil | 2009 |
Adenosine A2A receptor deficient mice are partially resistant to limbic seizures.
Topics: Adenosine; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Male; Mice; Mic | 2009 |
Postnatal caffeine treatment affects differently two pentylenetetrazol seizure models in rats.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Caffeine; Central Nervous System Stimu | 2009 |
Acceleration of pentylenetetrazol seizure kindling associated with induction of sensitized visual responses evoked by strobe stimulation.
Topics: Animals; Convulsants; Disease Models, Animal; Electrodes, Implanted; Kindling, Neurologic; Male; Mot | 2009 |
Complete brain-type creatine kinase deficiency in mice blocks seizure activity and affects intracellular calcium kinetics.
Topics: Animals; Behavior, Animal; Brain; Calcium; Creatine Kinase; Creatine Kinase, BB Form; Creatine Kinas | 2010 |
Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model.
Topics: Animals; Anticonvulsants; Clonazepam; Convulsants; Disease Models, Animal; Drug Interactions; Drug T | 2009 |
Evaluation of stereoselective anticonvulsant, teratogenic, and pharmacokinetic profile of valnoctylurea (capuride): a chiral stereoisomer of valproic acid urea derivative.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug | 2010 |
Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRalpha1 signaling.
Topics: Action Potentials; Age Factors; Animals; Animals, Newborn; Brain Mapping; Caspase 3; Cell Death; Cer | 2009 |
Mapping of c-Fos expression in the rat brain during the evolution of pentylenetetrazol-kindled seizures.
Topics: Analysis of Variance; Animals; Brain; Brain Mapping; Disease Models, Animal; Gene Expression Regulat | 2009 |
Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport.
Topics: Animals; Animals, Newborn; Aspartic Acid; Biophysics; Disease Models, Animal; Electric Stimulation; | 2009 |
Preferential increase in the hippocampal synaptic vesicle protein 2A (SV2A) by pentylenetetrazole kindling.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Mem | 2009 |
A revised Racine's scale for PTZ-induced seizures in rats.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Male; Motor Activity; Pen | 2009 |
Intestinal inflammation and seizure susceptibility: understanding the role of tumour necrosis factor-alpha in a rat model.
Topics: Animals; Brain; Catalase; Colitis; Colon; Disease Models, Animal; Female; Glutathione Peroxidase; Li | 2009 |
The effect of L-arginine and L-NAME on pentylenetetrazole induced seizures in ovariectomized rats, an in vivo study.
Topics: Analysis of Variance; Animals; Anticonvulsants; Arginine; Disease Models, Animal; Enzyme Inhibitors; | 2009 |
Antiseizure effects of 3alpha-androstanediol and/or 17beta-estradiol may involve actions at estrogen receptor beta.
Topics: Analysis of Variance; Androgen Antagonists; Androstane-3,17-diol; Animals; Anticonvulsants; Disease | 2009 |
Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Cannabidiol; Disease Models, Animal; F | 2010 |
Zolpidem is a potent anticonvulsant in adult and aged mice.
Topics: Age Factors; Aging; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interact | 2010 |
Seizure susceptibility alteration through 5-HT(3) receptor: modulation by nitric oxide.
Topics: Animals; Anticonvulsants; Arginine; Disease Models, Animal; Disease Susceptibility; Dose-Response Re | 2010 |
Anticonvulsant effects of Searsia dentata (Anacardiaceae) leaf extract in rats.
Topics: Anacardiaceae; Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Epilepsy; Kainic Acid; | 2010 |
ATP-sensitive potassium channels contribute to the time-dependent alteration in the pentylenetetrazole-induced seizure threshold in diabetic mice.
Topics: Analysis of Variance; Animals; Blood Glucose; Body Weight; Cromakalim; Diabetes Mellitus, Experiment | 2010 |
Selection of two lines of mice based on latency to onset of methionine sulfoximine seizures.
Topics: Animals; Cerebral Cortex; Convulsants; Crosses, Genetic; Disease Models, Animal; Dizocilpine Maleate | 2010 |
Synthesis and anticonvulsant activities of (R)-N-(4'-substituted)benzyl 2-acetamido-3-methoxypropionamides.
Topics: Acetamides; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroshock; Hippocampus | 2010 |
Efficacy of 3,5-dibromo-L-phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Endothelin-1; Gait Disorders, Neurologic; Glut | 2009 |
Age- and dose-specific anticonvulsant action of bumetanide in immature rats.
Topics: Age Factors; Aging; Animals; Anticonvulsants; Bumetanide; Disease Models, Animal; Dose-Response Rela | 2009 |
Circadian locomotor rhythms are normal in Ts65Dn "Down syndrome" mice and unaffected by pentylenetetrazole.
Topics: Animals; Circadian Rhythm; Darkness; Disease Models, Animal; Down Syndrome; Mice; Motor Activity; Pe | 2010 |
Antiepileptogenic and anticonvulsive actions of levetiracetam in a pentylenetetrazole kindling model.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Dru | 2010 |
Evaluation of the anticonvulsant effect of Centella asiatica (gotu kola) in pentylenetetrazol-induced seizures with respect to cholinergic neurotransmission.
Topics: Acetylcholine; Acetylcholinesterase; Analysis of Variance; Animals; Anticonvulsants; Brain; Centella | 2010 |
Acute administration of docosahexaenoic acid increases resistance to pentylenetetrazol-induced seizures in rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Docosahexaenoic Acids; Dose- | 2010 |
Δ⁹-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats.
Topics: Animals; Cerebral Cortex; Competitive Bidding; Disease Models, Animal; Dronabinol; Drug Interactions | 2010 |
Increased hippocampal T2 in a rat model of pentylenetetrazol-induced kindling correlates with seizure scores.
Topics: Analysis of Variance; Animals; Cell Count; Disease Models, Animal; Glial Fibrillary Acidic Protein; | 2010 |
Involvement of nitric oxide-cGMP pathway in the anticonvulsant effects of lithium chloride on PTZ-induced seizure in mice.
Topics: Animals; Anticonvulsants; Arginine; Convulsants; Cyclic GMP; Disease Models, Animal; Dose-Response R | 2010 |
Magnesium supplementation enhances the anticonvulsant potential of valproate in pentylenetetrazol-treated rats.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Drug Synergism; gamma-Aminobutyric Acid; Gl | 2010 |
Time course of changes in the concentrations of monoamines in the brain structures of pentylenetetrazole-kindled rats.
Topics: Analysis of Variance; Animals; Biogenic Monoamines; Brain; Chromatography, High Pressure Liquid; Dis | 2010 |
Effects of pharmacological entopeduncular manipulations on idiopathic dystonia in the dt(sz) mutant hamster.
Topics: Animals; Animals, Newborn; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dru | 2010 |
Anticonvulsant and proconvulsant actions of 2-deoxy-D-glucose.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Anticonvulsants; Antimetabolites; Blood Glucos | 2010 |
[Understanding the pathophysiology of epilepsy in an animal model: pentylenetetrazole induces activation but not death of neurons of the medial extended amygdala].
Topics: Amygdala; Animals; Convulsants; Disease Models, Animal; Epilepsy; Humans; Male; Nerve Degeneration; | 2010 |
Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway.
Topics: Agmatine; Analysis of Variance; Animals; Antidepressive Agents; Arginine; Disease Models, Animal; Do | 2010 |
Stress within the postseizure time window inhibits seizure recurrence.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Anticonvulsants; Circadian Rhythm; Corticos | 2010 |
Amygdala-specific reduction of alpha1-GABAA receptors disrupts the anticonvulsant, locomotor, and sedative, but not anxiolytic, effects of benzodiazepines in mice.
Topics: Amygdala; Animals; Animals, Newborn; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Cell Lin | 2010 |
Antioxidant potential of curcumin against oxidative insult induced by pentylenetetrazol in epileptic rats.
Topics: Alkaloids; Animals; Antioxidants; Benzodioxoles; Biological Availability; Carbamazepine; Catalase; C | 2010 |
Modeling seizure-related behavioral and endocrine phenotypes in adult zebrafish.
Topics: Animals; Behavior, Animal; Caffeine; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fema | 2010 |
Anticonvulsant effects of methyl ethyl ketone and diethyl ketone in several types of mouse seizure models.
Topics: Acetone; Animals; Anticonvulsants; Butanones; Carbolines; Disease Models, Animal; Electroshock; Kain | 2010 |
An experimental study of the anticonvulsant effect of amlodipine in mice.
Topics: Amlodipine; Animals; Anticonvulsants; Calcium Channel Blockers; Convulsants; Disease Models, Animal; | 2010 |
Neonatal exposure to low-dose domoic acid lowers seizure threshold in adult rats.
Topics: Action Potentials; Animals; Animals, Newborn; Convulsants; Disease Models, Animal; Epilepsy; Kainic | 2010 |
Voltage-dependent calcium channel and NMDA receptor antagonists augment anticonvulsant effects of lithium chloride on pentylenetetrazole-induced clonic seizures in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Calcium Channel Blockers; Disease Models, Animal; Do | 2010 |
The differential effects of protein synthesis inhibition on the expression and reconsolidation of pentylenetetrazole kindled seizures.
Topics: Animals; Cycloheximide; Disease Models, Animal; Drug Interactions; Exploratory Behavior; Fear; Gene | 2010 |
Influence of etoricoxib on anticonvulsant activity of phenytoin and diazepam in experimental seizure models in mice.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug I | 2010 |
Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice.
Topics: Animals; Anticonvulsants; Berberine; Diazepam; Disease Models, Animal; Dose-Response Relationship, D | 2010 |
Central nervous system activity of the proanthocyanidin-rich fraction obtained from Croton celtidifolius in rats.
Topics: Anesthetics, Inhalation; Animals; Anti-Anxiety Agents; Anticonvulsants; Antipsychotic Agents; Apomor | 2010 |
Effect of short-term lead exposure on PTZ-induced seizure threshold in mice.
Topics: Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking; Drug Inter | 2010 |
Mice lacking Melanin Concentrating Hormone 1 receptor are resistant to seizures.
Topics: Animals; Disease Models, Animal; Kaplan-Meier Estimate; Mice; Mice, Inbred C57BL; Mice, Knockout; N- | 2010 |
Effect of phosphamidon on convulsive behavior and biochemical parameters: modulation by progesterone and 4'-chlorodiazepam in rats.
Topics: Acetylcholinesterase; Acute Disease; Animals; Antioxidants; Behavior, Animal; Brain; Chronic Disease | 2010 |
Comparative pharmacodynamic and pharmacokinetic analysis of two anticonvulsant halo derivatives of 2,2,3,3-tetramethylcyclopropanecarboxamide, an amide of a cyclic analog of valproic acid.
Topics: Abnormalities, Drug-Induced; Amides; Analgesics; Animals; Anticonvulsants; Cyclopropanes; Disease Mo | 2010 |
[Effect of Chaihu Shugan Tang on excitability in different brain regions of pentylenetetrazole-kindled chronic epileptic rats].
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Aspartic Acid; Brain; Chronic Disease; Deoxyglucose; Disease | 2010 |
Halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine produces beneficial effects in experimental stroke and seizures.
Topics: Animals; Blood Pressure; Brain; Caspase 3; Disease Models, Animal; Endothelin-1; Epilepsy; Heart Rat | 2011 |
Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model.
Topics: Administration, Oral; Animals; Anticonvulsants; Antioxidants; Avoidance Learning; Cognition Disorder | 2010 |
Effect of pentylenetetrazole and sound stimulation induced single and repeated convulsive seizures on the MDA, GSH and NO levels, and SOD activities in rat liver and kidney tissues.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Convulsants; Disease Models, Animal; Glutathion | 2010 |
Involvement of the nitric oxide pathway in the anticonvulsant effect of tramadol on pentylenetetrazole-induced seizures in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Arginine; Disease Models, Animal; Dose-Response Rela | 2010 |
Anticonvulsant effect of (E)-2-benzylidene-4-phenyl-1,3-diselenole in a pilocarpine model in mice.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Antioxidants; Brain; Disease Models, Animal; Dose-Respons | 2010 |
Seizure-induced changes in neuropeptide Y-containing cortical neurons: Potential role for seizure threshold and epileptogenesis.
Topics: Animals; Cell Count; Cerebral Cortex; Disease Models, Animal; Electroshock; Gene Expression Regulati | 2010 |
Comparative anticonvulsant efficacy in the corneal kindled mouse model of partial epilepsy: Correlation with other seizure and epilepsy models.
Topics: Animals; Anticonvulsants; Biophysics; Cornea; Disease Models, Animal; Drug Evaluation, Preclinical; | 2010 |
The anticonvulsant effects of propofol and a propofol analog, 2,6-diisopropyl-4-(1-hydroxy-2,2,2-trifluoroethyl)phenol, in a 6 Hz partial seizure model.
Topics: Animals; Anticonvulsants; Ataxia; Disease Models, Animal; Dose-Response Relationship, Drug; Electric | 2011 |
A single episode of neonatal seizures alters the cerebellum of immature rats.
Topics: Animals; Animals, Newborn; Autoradiography; Calbindins; Cell Count; Cell Proliferation; Cerebellum; | 2011 |
Anticonvulsant effect of celecoxib on pentylenetetrazole-induced convulsion: Modulation by NO pathway.
Topics: Animals; Anticonvulsants; Arginine; Celecoxib; Disease Models, Animal; Dose-Response Relationship, D | 2010 |
The evaluation of nitric oxide involvement in metrazol induced status epilepticus using multiparametric monitoring.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Femoral Vein; Infusions, Intravenous; Male; Monito | 2011 |
Anticonvulsant activity of BmK AS, a sodium channel site 4-specific modulator.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cells, Cultured; Convulsants; Dise | 2011 |
Effect of lamotrigine, oxcarbazepine and topiramate on cognitive functions and oxidative stress in PTZ-kindled mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Catalase; Cognition Disorders; Disease Models, Animal; Drug | 2011 |
Study of epileptiform activity in cerebral ganglion of mud crab Scylla serrata.
Topics: Animals; Anticonvulsants; Brachyura; Convulsants; Disease Models, Animal; Epilepsy; gamma-Aminobutyr | 2011 |
A novel series of 2,5-disubstituted 1,3,4-oxadiazoles: synthesis and SAR study for their anticonvulsant activity.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Magnetic Resonance Spectroscopy; Mass Spectrometry | 2011 |
Anticonvulsant profile of the alkaloids (+)-erythravine and (+)-11-α-hydroxy-erythravine isolated from the flowers of Erythrina mulungu Mart ex Benth (Leguminosae-Papilionaceae).
Topics: Animals; Anticonvulsants; Bicuculline; Chi-Square Distribution; Disease Models, Animal; Dose-Respons | 2011 |
Anticonvulsant and antioxidant actions of trimetazidine in pentylenetetrazole-induced kindling model in mice.
Topics: Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Ep | 2011 |
Focused ultrasound-mediated suppression of chemically-induced acute epileptic EEG activity.
Topics: Animals; Brain; Brain Waves; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, | 2011 |
Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice.
Topics: Animals; Anti-Anxiety Agents; Dehydroepiandrosterone Sulfate; Disease Models, Animal; Dose-Response | 2011 |
A neuroprotective role for polyamines in a Xenopus tadpole model of epilepsy.
Topics: Animals; Convulsants; Cytoprotection; Disease Models, Animal; Epilepsy; Larva; Organ Culture Techniq | 2011 |
Morphine sensitization in the pentylenetetrazole-induced clonic seizure threshold in mice: role of nitric oxide and μ receptors.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Male; Mice; Mo | 2011 |
Synthesis and anticonvulsant properties of 1-(amino-N-arylmethanethio)-3-(1-substituted benzyl-2, 3-dioxoindolin-5-yl) urea derivatives.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, | 2011 |
The role of 5-HT(3) receptors in the additive anticonvulsant effects of citalopram and morphine on pentylenetetrazole-induced clonic seizures in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Biguanides; Citalopram; Disease Models, Animal; Dose | 2011 |
Clavulanic acid does not affect convulsions in acute seizure tests in mice.
Topics: Analysis of Variance; Animals; Clavulanic Acid; Convulsants; Disease Models, Animal; Electroshock; E | 2012 |
Can propofol cause seizures? an experimental study.
Topics: Animals; Apoptosis; Convulsants; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationsh | 2011 |
Recording the adult zebrafish cerebral field potential during pentylenetetrazole seizures.
Topics: Action Potentials; Amplifiers, Electronic; Animals; Behavior, Animal; Cerebrum; Convulsants; Disease | 2011 |
Neuroprotective effect of vitamin C against PTZ induced apoptotic neurodegeneration in adult rat brain.
Topics: Animals; Apoptosis; Ascorbic Acid; Brain; Caspase 3; Disease Models, Animal; Epilepsy; Male; Nerve D | 2011 |
Effect of intracranial administration of ethosuximide in rats with spontaneous or pentylenetetrazol-induced spike-wave discharges.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy, Absence; Ethosuximide; Infusions, | 2011 |
[Involvement of Cdk5/p35 and tau protein in the hippocampal mossy fiber sprouting in the PTZ kindling model].
Topics: Animals; Cyclin-Dependent Kinase 5; Disease Models, Animal; Kindling, Neurologic; Male; Mossy Fibers | 2011 |
Closed-loop seizure control on epileptic rat models.
Topics: Animals; Artificial Intelligence; Brain; Convulsants; Disease Models, Animal; Electric Impedance; El | 2011 |
Effects of WIN 55,212-2 mesylate (a synthetic cannabinoid) on the protective action of clonazepam, ethosuximide, phenobarbital and valproate against pentylenetetrazole-induced clonic seizures in mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Benzoxazines; Brain; Cannabinoid Receptor Agonists; Cl | 2011 |
Spadin as a new antidepressant: absence of TREK-1-related side effects.
Topics: Animals; Antidepressive Agents; Biophysical Phenomena; Blood Glucose; Brain Infarction; CD8 Antigens | 2012 |
Paradoxical effect of noradrenaline-mediated neurotransmission in the antinociceptive phenomenon that accompanies tonic-clonic seizures: role of locus coeruleus neurons and α(2)- and β-noradrenergic receptors.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic Neurons; Animals; Disease Models, Animal; Dose-R | 2011 |
Acetylcholine-mediated neurotransmission within the nucleus raphe magnus exerts a key role in the organization of both interictal and postictal antinociception.
Topics: Acetylcholine; Animals; Atropine; Cholinergic Agonists; Cholinergic Antagonists; Disease Models, Ani | 2011 |
The interaction of melatonin and agmatine on pentylenetetrazole-induced seizure threshold in mice.
Topics: Agmatine; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Rela | 2011 |
Anticonvulsant and depressant effects of aqueous extracts of Carum copticum seeds in male rats.
Topics: Amygdala; Analysis of Variance; Animals; Anticonvulsants; Carum; Disease Models, Animal; Dose-Respon | 2011 |
Effects of midazolam and phenobarbital on brain oxidative reactions induced by pentylenetetrazole in a convulsion model.
Topics: Animals; Brain; Cerebral Cortex; Disease Models, Animal; Gene Expression; Heme Oxygenase-1; Hippocam | 2012 |
Khat (Catha edulis) and ethanol co-dependence modulate seizure expression in a pentylenetetrazol seizure model.
Topics: Alcoholism; Animals; Catha; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism | 2011 |
An early decrease in cell proliferation after pentylenetetrazole-induced seizures.
Topics: Animals; Bromodeoxyuridine; Cell Count; Cell Proliferation; Convulsants; Disease Models, Animal; Dos | 2011 |
Sulfobutyl ether(7) β-cyclodextrin (SBE(7) β-CD) carbamazepine complex: preparation, characterization, molecular modeling, and evaluation of in vivo anti-epileptic activity.
Topics: Administration, Oral; Animals; Anticonvulsants; beta-Cyclodextrins; Calorimetry, Differential Scanni | 2011 |
Design and pharmacological activity of glycinamide and N-methoxy amide derivatives of analogs and constitutional isomers of valproic acid.
Topics: Amides; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroshock; Female; Isomeri | 2011 |
Assessment of the convulsant liability of antidepressants using zebrafish and mouse seizure models.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Antidepressive Agents; Behavior, Anima | 2011 |
Synthesis and anticonvulsant activity of some 2-(2-{1-[substituted phenyl]ethylidene}hydrazinyl)-4-(4-methoxy-phenyl)-6-oxo-1,6-dihydro-pyrimidine-5-carbonitrile.
Topics: Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Depressants; Convulsants; Disease | 2012 |
Design, synthesis and screening of quinoline-incorporated thiadiazole as a potential anticonvulsant.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Drug Design; Male; Mice; Pentyle | 2012 |
Root extract of Anacyclus pyrethrum ameliorates seizures, seizure-induced oxidative stress and cognitive impairment in experimental animals.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Avoidance Learning; Brain; Butyrylcholinesteras | 2012 |
Design, synthesis and evaluation of anticonvulsant activity of pyridinyl-pyrrolidones: a pharmacophore hybrid approach.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Fe | 2012 |
Role of neurosteroids in the anticonvulsant activity of midazolam.
Topics: 5-alpha Reductase Inhibitors; Animals; Anticonvulsants; Clonazepam; Convulsants; Disease Models, Ani | 2012 |
Liposomal formulation of curcumin attenuates seizures in different experimental models of epilepsy in mice.
Topics: Animals; Anticonvulsants; Biological Availability; Chemistry, Pharmaceutical; Curcumin; Disease Mode | 2013 |
Regulatory role of the dopamine and norepinephrine transporters in pentylenetetrazol-kindled mice: association with effect of antidepressants.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Atomoxetine Hydrochloride; Bupropion; | 2011 |
Creatine reduces oxidative stress markers but does not protect against seizure susceptibility after severe traumatic brain injury.
Topics: Animals; Brain Injuries; Creatine; Dietary Supplements; Disease Models, Animal; Electroencephalograp | 2012 |
Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models.
Topics: Acetates; Animals; Anticonvulsants; Antioxidants; Catalase; Corpus Striatum; Disease Models, Animal; | 2011 |
Synthesis and anticonvulsant evaluation of dimethylethanolamine analogues of valproic acid and its tetramethylcyclopropyl analogue.
Topics: Animals; Anticonvulsants; Brain Waves; Convulsants; Cyclopropanes; Deanol; Disease Models, Animal; E | 2012 |
Age dependent learning and memory deficit in Pentylenetetrazol kindled mice.
Topics: Aging; Animals; Behavior, Animal; Disease Models, Animal; Epilepsy; Feasibility Studies; Learning; M | 2012 |
Characterization of PTZ-induced seizure susceptibility in a down syndrome mouse model that overexpresses CSTB.
Topics: Animals; Atrophy; Brain; Cystatin B; Disease Models, Animal; Disease Susceptibility; Down Syndrome; | 2011 |
Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy.
Topics: Action Potentials; Animals; Biophysics; Caveolin 1; Cell Line, Transformed; Disease Models, Animal; | 2011 |
Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models.
Topics: Amygdala; Analysis of Variance; Animals; Antioxidants; Cell Line, Tumor; Convulsants; Disease Models | 2012 |
Proconvulsive effects of oxytocin in the generalized pentylenetetrazol mouse model are mediated by vasopressin 1a receptors.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Mice; Mice, Inbred C57BL; Oxytoci | 2012 |
Striking differences in proconvulsant-induced alterations of seizure threshold in two rat models.
Topics: Animals; Anticonvulsants; Caffeine; Central Nervous System Stimulants; Chlorpromazine; Convulsants; | 2012 |
Pentylenetetrazole-induced seizures cause acute, but not chronic, mTOR pathway activation in rat.
Topics: Acute Disease; Animals; Chronic Disease; Convulsants; Disease Models, Animal; Enzyme Activation; Epi | 2012 |
Triheptanoin in acute mouse seizure models.
Topics: Acute Disease; Animals; Anticonvulsants; Disease Models, Animal; Mice; Mice, Inbred C3H; Pentylenete | 2012 |
Acute seizure tests in epilepsy research: electroshock- and chemical-induced convulsions in the mouse.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Dru | 2009 |
Effect of medroxyprogesterone on development of pentylenetetrazole-induced kindling in mice.
Topics: Animals; Anticonvulsants; Contraceptives, Oral, Synthetic; Convulsants; Disease Models, Animal; Epil | 2012 |
UPLC-TOF-MS analysis of Galium spurium towards its neuroprotective and anticonvulsant activities.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Butyrylcholinesterase; Cholinesterase Inhibitors; Ch | 2012 |
Sub-chronic treatment with pioglitazone exerts anti-convulsant effects in pentylenetetrazole-induced seizures of mice: The role of nitric oxide.
Topics: Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Drug Administration Routes; | 2012 |
Influence of carvedilol on anticonvulsant effect of gabapentin.
Topics: Amines; Analysis of Variance; Animals; Anticonvulsants; Brain; Carbazoles; Carvedilol; Convulsants; | 2011 |
Anatomically dependent anticonvulsant properties of temporally-coded electrical stimulation.
Topics: Amygdala; Animals; Disease Models, Animal; Electric Stimulation Therapy; Epilepsy, Generalized; Male | 2012 |
Distinct models of induced hyperactivity in zebrafish larvae.
Topics: 4-Aminopyridine; Aconitine; Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Dose-Respons | 2012 |
Chronic administration of atorvastatin induced anti-convulsant effects in mice: the role of nitric oxide.
Topics: Analysis of Variance; Animals; Anticonvulsants; Atorvastatin; Convulsants; Disease Models, Animal; D | 2012 |
Anticonvulsant effect of Marsilea quadrifolia Linn. on pentylenetetrazole induced seizure: a behavioral and EEG study in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Brain Waves; Disease Models, Animal; Electroencep | 2012 |
Endogenous ACh effects on NMDA-induced interictal-like discharges along the septotemporal hippocampal axis of adult rats and their modulation by an early life generalized seizure.
Topics: Acetylcholine; Analysis of Variance; Animals; Atropine; Cholinesterase Inhibitors; Convulsants; Dise | 2012 |
Phytochemical studies of the phenolic substances in Aster glehni extract and its sedative and anticonvulsant activity.
Topics: Animals; Anticonvulsants; Aster Plant; Chromatography, High Pressure Liquid; Disease Models, Animal; | 2012 |
Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Anticonvulsants; Chromatography, High | 2012 |
Decreased GABABR expression and increased neuronal cell death in developing rat brain after PTZ-induced seizure.
Topics: Animals; Animals, Newborn; Baclofen; Caspase 3; Cell Death; Disease Models, Animal; Electroencephalo | 2013 |
Imaging brain neuronal activity using functionalized magnetonanoparticles and MRI.
Topics: Afferent Pathways; Animals; Brain; Brain Mapping; Convulsants; Dextrans; Disease Models, Animal; Ele | 2012 |
Influence of calcium channel blockers on anticonvulsant and antinociceptive activities of valproic acid in pentylenetetrazole-kindled mice.
Topics: Analgesics; Animals; Anticonvulsants; Calcium Channel Blockers; Disease Models, Animal; Drug Synergi | 2012 |
Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; GABA-A Receptor Agoni | 2012 |
A larval zebrafish model of bipolar disorder as a screening platform for neuro-therapeutics.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Bipolar Disorder; Dark Ada | 2012 |
Sildenafil influences the anticonvulsant activity of vigabatrin and gabapentin in the timed pentylenetetrazole infusion test in mice.
Topics: Amines; Animals; Anticonvulsants; Avoidance Learning; Cyclohexanecarboxylic Acids; Disease Models, A | 2012 |
Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures.
Topics: Animals; Anticonvulsants; Central Nervous System; Disease Models, Animal; Drug Evaluation, Preclinic | 2012 |
Decreased susceptibility to seizures induced by pentylenetetrazole in serine racemase knockout mice.
Topics: Amino Acids; Analysis of Variance; Animals; Brain; Chromatography, High Pressure Liquid; Convulsants | 2012 |
Effect of ACEA--a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Avoidance Learning; Cannabinoid Receptor Agonists; Dise | 2012 |
Partial agonist of benzodiazepine receptors Ro 19-8022 elicits withdrawal symptoms after short-term administration in immature rats.
Topics: Age Factors; Animals; Anticonvulsants; Brain; Carrier Proteins; Disease Models, Animal; Drug Adminis | 2012 |
Effects of ethylenediamine in rodent models of seizure, motor coordination and anxiety.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Convulsants; Disease Models, Animal; Electro | 2012 |
Closed-loop neural stimulation for pentylenetetrazole-induced seizures in zebrafish.
Topics: Animals; Anticonvulsants; Brain Stem; Convulsants; Disease Models, Animal; Electric Stimulation Ther | 2013 |
ONO-2506 inhibits spike-wave discharges in a genetic animal model without affecting traditional convulsive tests via gliotransmission regulation.
Topics: Animals; Anticonvulsants; Astrocytes; Caprylates; Cells, Cultured; Convulsants; Disease Models, Anim | 2013 |
The involvement of nitric oxide in the anti-seizure effect of acute atorvastatin treatment in mice.
Topics: Animals; Anticonvulsants; Atorvastatin; Brain; Convulsants; Disease Models, Animal; Dose-Response Re | 2012 |
Plausible antioxidant biomechanics and anticonvulsant pharmacological activity of brain-targeted β-carotene nanoparticles.
Topics: Analysis of Variance; Animals; Anticonvulsants; Antioxidants; beta Carotene; Brain; Calorimetry, Dif | 2012 |
Cannabidivarin is anticonvulsant in mouse and rat.
Topics: Animals; Anticonvulsants; Cannabinoids; Cannabis; Disease Models, Animal; Female; Hippocampus; In Vi | 2012 |
Probing the role of the sodium/calcium exchanger in pentylenetetrazole-induced generalized seizures in rats.
Topics: Animals; Anticonvulsants; Benzyl Compounds; Chi-Square Distribution; Convulsants; Disease Models, An | 2013 |
Pentylenetetrazol (PTZ) kindling model of epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Kindling, Neurologic; Mice; Pentylenetetrazole | 2012 |
Effects of extremely low frequency electromagnetic field (50 Hz) on pentylenetetrazol-induced seizures in mice.
Topics: Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Radiation; Electromagnetic | 2013 |
Overexpression of multidrug resistance-associated protein 2 in the brain of pentylenetetrazole-kindled rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Chromatography, Liquid; Coloring Agents; Conv | 2012 |
The antidepressant sertraline prevents the behavioral and EEG changes induced in two animal models of seizures.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Electroence | 2012 |
Synthesis and anticonvulsant properties of new N-Mannich bases derived from 3,3-diphenyl- and 3-ethyl-3-methyl-pyrrolidine-2,5-diones. Part III.
Topics: Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Male; Mannich Bases; Mice; | 2013 |
Differential seizure response in two models of cortical heterotopia.
Topics: Agenesis of Corpus Callosum; Animals; Cerebral Cortex; Choristoma; Convulsants; Disease Models, Anim | 2013 |
Anticonvulsant action of indazole.
Topics: Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Dru | 2013 |
Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Disease Models, Animal; Disease Susceptibility; Disks La | 2012 |
[Effects of Wuling mycelia on pentylenetetrazole-induced epilepsy in rats].
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Epilepsy; Hippocampus; Histamine; Kindling, | 2012 |
Oxytocin inhibits pentylentetrazol-induced seizures in the rat.
Topics: Animals; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy; Male; Oxyt | 2013 |
[Effect of acute stress stimulation on the seizure induction in epileptic model rats].
Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy; Lithium Chloride; Pentylenetetrazole; P | 2012 |
Anticonvulsant, neuroprotective and behavioral effects of organic and conventional yerba mate (Ilex paraguariensis St. Hil.) on pentylenetetrazol-induced seizures in Wistar rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Catalase; Chromatography, High Pressure Liquid; Conv | 2013 |
Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish.
Topics: Adenine Nucleotides; Adenosine; Adenosine Deaminase; Amines; Animals; Anticonvulsants; Brain; Cycloh | 2013 |
Behavioural and histopathological assessment of the effects of periodic fasting on pentylenetetrazol-induced seizures in rats.
Topics: Animals; Apoptosis; Disease Models, Animal; Epilepsy; Fasting; Hippocampus; Male; Neurons; Pentylene | 2013 |
L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures.
Topics: Animals; Disease Models, Animal; GABA Agents; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hi | 2013 |
Effect of saponin fraction from Ficus religiosa on memory deficit, and behavioral and biochemical impairments in pentylenetetrazol kindled mice.
Topics: Analysis of Variance; Animals; Avoidance Learning; Brain; Chromatography, High Pressure Liquid; Depr | 2013 |
Seizures induced by pentylenetetrazole in the adult zebrafish: a detailed behavioral characterization.
Topics: Animals; Behavior, Animal; Brain; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Relat | 2013 |
Effects of cannabinoids and endocannabinoid hydrolysis inhibition on pentylenetetrazole-induced seizure and electroencephalographic activity in rats.
Topics: Animals; Benzamides; Benzoxazines; Cannabinoids; Carbamates; Convulsants; Disease Models, Animal; El | 2013 |
A minimum of 3 months of dietary fish oil supplementation is required to raise amygdaloid afterdischarge seizure thresholds in rats--implications for treating complex partial seizures.
Topics: Amygdala; Animals; Body Weight; Convulsants; Disease Models, Animal; Docosahexaenoic Acids; Dose-Res | 2013 |
Effects of locally administered pentylenetetrazole on nigral single unit activity and severity of dystonia in a genetic model of paroxysmal dystonia.
Topics: Action Potentials; Animals; Behavior, Animal; Convulsants; Cricetinae; Disease Models, Animal; Dysto | 2002 |
Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures.
Topics: Aging; Animals; Animals, Newborn; Cerebellar Cortex; Disease Models, Animal; Disease Susceptibility; | 2002 |
Dose-, time-, age-, and sex-response profiles for the anticonvulsant effects of deoxycorticosterone in 15-day-old rats.
Topics: Age Factors; Animals; Anticonvulsants; Desoxycorticosterone; Disease Models, Animal; Dose-Response R | 2002 |
Maternal deprivation stress exacerbates cognitive deficits in immature rats with recurrent seizures.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Cognition Disorders; Cyclic AMP Response Element | 2002 |
Secretory phospholipase A2 and phospholipids in neural membranes in an experimental epilepsy model.
Topics: Animals; Cell Membrane; Cerebellum; Cerebral Cortex; Convulsants; Disease Models, Animal; Epilepsy; | 2002 |
Consequences of nitric oxide generation in epileptic-seizure rodent models as studied by in vivo EPR.
Topics: Analysis of Variance; Animals; Brain; Disease Models, Animal; Electron Spin Resonance Spectroscopy; | 2002 |
The effect of the 'classic' ketogenic diet on animal seizure models.
Topics: Animals; Disease Models, Animal; Electroshock; Ketone Bodies; Male; Pentylenetetrazole; Rats; Rats, | 2003 |
Assessment of the seizure susceptibility of Wistar Audiogenic rat to electroshock, pentyleneterazole and pilocarpine.
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Convulsants; Disease Models, Animal; Electroshock; | 2003 |
Kindling status in sprague-dawley rats induced by pentylenetetrazole: involvement of a critical development period.
Topics: Animals; Biomarkers; Blotting, Northern; Disease Models, Animal; Disease Susceptibility; Epilepsy; G | 2003 |
The effects of sarmesin, an Angiotensin II analogue on seizure susceptibility, memory retention and nociception.
Topics: Angiotensin II; Animals; Avoidance Learning; Disease Models, Animal; Drug Combinations; Imidazoles; | 2003 |
Electroencephalographic characterisation of pentylenetetrazole-induced seizures in mice lacking the alpha 4 subunit of the neuronal nicotinic receptor.
Topics: Animals; Disease Models, Animal; Electroencephalography; GABA Antagonists; Mice; Mice, Inbred C57BL; | 2003 |
22-kHz ultrasonic vocalization in rats as an index of anxiety but not fear: behavioral and pharmacological modulation of affective state.
Topics: Animals; Anxiety; Behavior, Animal; Buspirone; Carbolines; Conditioning, Classical; Diagnosis, Diffe | 2003 |
Effect of topiramate on the anticonvulsant activity of conventional antiepileptic drugs in two models of experimental epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, | 2003 |
Neurochemical characteristics of the ventromedial hypothalamus in mediating the antiaversive effects of anxiolytics in different models of anxiety.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti- | 2003 |
Changes in the blood-brain barrier permeability and in the brain tissue trace element concentrations after single and repeated pentylenetetrazole-induced seizures in rats.
Topics: Animals; Blood-Brain Barrier; Brain Chemistry; Coloring Agents; Copper; Disease Models, Animal; Evan | 2003 |
Validation of a modified mirrored chamber sensitive to anxiolytics and anxiogenics in mice.
Topics: Animals; Animals, Outbred Strains; Anti-Anxiety Agents; Anxiety; Carbolines; Dextroamphetamine; Diaz | 2003 |
Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial?
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Brain; Chromatography, Liquid; Disease Models, Anima | 2003 |
Is spontaneous high-voltage rhythmic spike discharge in Long Evans rats an absence-like seizure activity?
Topics: Animals; Anticonvulsants; Arousal; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Electr | 2004 |
Changes in nucleotide hydrolysis in rat blood serum induced by pentylenetetrazol-kindling.
Topics: 5'-Nucleotidase; Adenine Nucleotides; Adenosine; Animals; Apyrase; Biomarkers; Brain; Convulsants; D | 2003 |
Dentate granule cell neurogenesis after seizures induced by pentylenetrazol in rats.
Topics: Animals; Antigens, Nuclear; Benzopyrans; Bromodeoxyuridine; Calbindins; Cell Count; Cell Division; C | 2003 |
The pentylenetetrazole-kindling model of epilepsy in SAMP8 mice: glial-neuronal metabolic interactions.
Topics: Acetic Acid; Age Factors; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Epilepsy; G | 2003 |
An animal model of generalized nonconvulsive status epilepticus: immediate characteristics and long-term effects.
Topics: Age Factors; Animals; Behavior, Animal; Brain; Cognition; Convulsants; Disease Models, Animal; Disea | 2003 |
[Role of NMDA and AMPA glutamate receptors in the mechanism of korazol-induced convulsions in mice].
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Mole | 2003 |
Nantenine alkaloid presents anticonvulsant effect on two classical animal models.
Topics: Alkaloids; Animals; Anticonvulsants; Aporphines; Disease Models, Animal; Dose-Response Relationship, | 2003 |
Right-sided vagus nerve stimulation reduces generalized seizure severity in rats as effectively as left-sided.
Topics: Animals; Disease Models, Animal; Electric Stimulation Therapy; Electrodes; Epilepsy, Generalized; Fu | 2003 |
Increase in drug-induced seizure susceptibility of transgenic mice overexpressing GABA transporter-1.
Topics: Animals; Animals, Genetically Modified; Anticonvulsants; Carrier Proteins; Disease Models, Animal; F | 2003 |
Electromagnetic waves of 900 MHz in acute pentylenetetrazole model in ontogenesis in mice.
Topics: Age Factors; Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Radiation; Ma | 2003 |
Anticonvulsant efficiency, behavioral performance and cortisol levels: a comparison of carbamazepine (CBZ) and a fatty acid compound (SR-3).
Topics: alpha-Linolenic Acid; Analysis of Variance; Animals; Anticonvulsants; Carbamazepine; Disease Models, | 2004 |
Evaluation of antiepileptic activity of aspirin in combination with newer antiepileptic lamotrigine in mice.
Topics: Animals; Anticonvulsants; Aspirin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Co | 2003 |
Induced seizures as therapy of experimental strokes in dogs.
Topics: Animals; Blood Pressure; Brain; Carotid Stenosis; Convulsants; Disease Models, Animal; Dogs; Electri | 1971 |
Effect of harmane on the convulsive threshold in epilepsy models in mice.
Topics: Animals; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; Female; Harmine; Male; Mice; P | 2003 |
Increased seizure threshold in mice lacking aquaporin-4 water channels.
Topics: Action Potentials; Animals; Aquaporin 4; Aquaporins; Brain; Brain Edema; Convulsants; Disease Models | 2004 |
Parvalbumin deficiency affects network properties resulting in increased susceptibility to epileptic seizures.
Topics: Action Potentials; Animals; Brain; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Geneti | 2004 |
The role of superoxide dismutase and alpha-tocopherol in the development of seizures and kindling induced by pentylenetetrazol - influence of the radical scavenger alpha-phenyl-N-tert-butyl nitrone.
Topics: alpha-Tocopherol; Analysis of Variance; Animals; Blotting, Western; Chromatography, High Pressure Li | 2004 |
The influence of gender on the aggravation of absence seizures by carbamazepine in the low-dose pentylenetetrazol rat model.
Topics: Animals; Anticonvulsants; Carbamazepine; Convulsants; Disease Models, Animal; Dose-Response Relation | 2004 |
Evidence of the antiepileptic potential of amiloride with neuropharmacological benefits in rodent models of epilepsy and behavior.
Topics: Amiloride; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Rel | 2004 |
The effects of pentylenetetrazole-induced status epilepticus on behavior, emotional memory, and learning in rats.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Emotions; Learning; Male; Motor Activity; Pentyle | 2004 |
Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models.
Topics: Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, | 2004 |
Sprouting and synaptic reorganization in the subiculum and CA1 region of the hippocampus in acute and chronic models of partial-onset epilepsy.
Topics: Acute Disease; Animals; Chronic Disease; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lob | 2004 |
Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans.
Topics: Alleles; Amino Acid Sequence; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Codo | 2004 |
Involvement of the neuropeptide corticotropin-releasing hormone in an animal model of Shigella-related seizures.
Topics: Animals; Corticotropin-Releasing Hormone; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; Pent | 2004 |
Continuous increase of epileptogenic effects following application of proteolytic enzymes (buccal ganglia of Helix pomatia).
Topics: Animals; Biological Clocks; Cheek; Convulsants; Disease Models, Animal; Enzymes; Epilepsy; Ganglia, | 2004 |
The interaction of cannabinoids and opioids on pentylenetetrazole-induced seizure threshold in mice.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Recepto | 2004 |
Seizure susceptibility to various convulsant stimuli in dystrophin-deficient mdx mice.
Topics: Acute Disease; Animals; Chronic Disease; Convulsants; Disease Models, Animal; Dystrophin; Epilepsy; | 2004 |
Increased seizure threshold and severity in young transgenic CRND8 mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Male; Mice; Mice | 2004 |
Effects of the anticholinesterase drug tacrine on the development of PTZ kindling and on learning and memory processes in mice.
Topics: Analysis of Variance; Animals; Avoidance Learning; Cholinesterase Inhibitors; Disease Models, Animal | 2000 |
Effects of kyotorphin and analogues on nociception and pentylenetetrazole seizures.
Topics: Analgesics; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Endorphins; Male; Pain; P | 2004 |
Genetic and phenotypic analysis of seizure susceptibility in PL/J mice.
Topics: Animals; Convulsants; Crosses, Genetic; Disease Models, Animal; Electroencephalography; Electroshock | 2004 |
Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Clonazepam; Disease Models, Animal; Drug Interactions; D | 2004 |
Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures.
Topics: Animals; Anticonvulsants; Bromides; Chronic Disease; Disease Models, Animal; Dog Diseases; Dogs; Dru | 2004 |
Ascorbate modulates pentylenetetrazol-induced convulsions biphasically.
Topics: Analysis of Variance; Animals; Antioxidants; Ascorbic Acid; Behavior, Animal; Brain Chemistry; Carbo | 2004 |
Biochemical brain markers and purinergic parameters in rat CSF after seizure induced by pentylenetetrazol.
Topics: Adenosine; Adenosine Diphosphate; Animals; Antigens, CD; Apyrase; Biomarkers; Brain; Convulsants; Di | 2004 |
Ethosuximide and valproate display high efficacy against lindane-induced seizures in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Co | 2004 |
Lipopolysaccharide-induced febrile convulsions in the rat: short-term sequelae.
Topics: Animals; Animals, Newborn; Body Temperature; Brain; Cell Death; Disease Models, Animal; Female; Feve | 2004 |
Ultra-low dose naltrexone potentiates the anticonvulsant effect of low dose morphine on clonic seizures.
Topics: Animals; Differential Threshold; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Syne | 2004 |
Ketogenic diet fed rats have low levels of S100B in cerebrospinal fluid.
Topics: Animals; Astrocytes; Biomarkers; Brain; Convulsants; Disease Models, Animal; Down-Regulation; Epilep | 2004 |
Progestins in the hippocampus of female rats have antiseizure effects in a pentylenetetrazole seizure model.
Topics: 5-alpha-Dihydroprogesterone; Animals; Anticonvulsants; Diestrus; Disease Models, Animal; Female; Hip | 2004 |
Studies of the roles of NMDA and AMPA glutamate receptors in the mechanism of corasole convulsions in mice.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists | 2004 |
The effects of the immature rat model of febrile seizures on the occurrence of later generalized tonic-clonic and absence epilepsy.
Topics: Action Potentials; Animals; Animals, Newborn; Brain; Causality; Convulsants; Disease Models, Animal; | 2005 |
Blockade of the membranal GABA transporter potentiates GABAergic responses evoked in pyramidal cells by mossy fiber activation after seizures.
Topics: Animals; Calcium Signaling; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Anta | 2005 |
Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bipolar Disorder; Carbamazepine; Central Nervous Syst | 2005 |
Anti-epileptogenic effect of beta-carotene and vitamin A in pentylenetetrazole-kindling model of epilepsy in mice.
Topics: Animals; Anticonvulsants; beta Carotene; Disease Models, Animal; Dose-Response Relationship, Drug; D | 2005 |
Proteomic identification of the involvement of the mitochondrial rieske protein in epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Electron Transport Complex III; Electrophoresis, Gel | 2005 |
Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Dose-Response Relation | 2005 |
Anticonvulsant effect of Hypericum perforatum: role of nitric oxide.
Topics: Animals; Anticonvulsants; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Drug | 2005 |
Anticonvulsant activity of Heracleum persicum seed.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, | 2005 |
Study of antiepileptic effect of extracts from Acorus tatarinowii Schott.
Topics: Acorus; Animals; Anticonvulsants; Brain; Disease Models, Animal; Electroshock; Epilepsy; gamma-Amino | 2005 |
Actions at GABA(A) receptors in the hippocampus may mediate some antiseizure effects of progestins.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Chlorides; Disease Mo | 2005 |
Pentylenetetrazole-induced convulsions affect cellular and molecular parameters of the mechanism of action of triiodothyronine in adult rat brain.
Topics: Animals; Blotting, Northern; Cerebral Cortex; Disease Models, Animal; Drug Interactions; Female; Gen | 2005 |
Erdosteine ameliorates PTZ-induced oxidative stress in mice seizure model.
Topics: Animals; Anticonvulsants; Brain Chemistry; Cerebral Cortex; Convulsants; Disease Models, Animal; Dru | 2005 |
Bilateral, vascular and perivascular glial upregulation of heat shock protein-27 after repeated epileptic seizures.
Topics: Animals; Astrocytes; Blotting, Western; Brain; Convulsants; Disease Models, Animal; Electroencephalo | 2005 |
Anticonvulsant properties of the novel nootropic agent nefiracetam in seizure models of mice and rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, | 2005 |
Target-specific catecholamine elevation induced by anticonvulsant thalamic deep brain stimulation.
Topics: Animals; Brain; Catecholamines; Chromatography, High Pressure Liquid; Deep Brain Stimulation; Diseas | 2005 |
Pentylenetetrazol-induced seizures affect the levels of prolyl oligopeptidase, thimet oligopeptidase and glial proteins in rat brain regions, and attenuation by MK-801 pretreatment.
Topics: Animals; Brain; CD11b Antigen; Cerebral Cortex; Convulsants; Disease Models, Animal; Dizocilpine Mal | 2005 |
The effects of chronic norepinephrine transporter inactivation on seizure susceptibility in mice.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Disease Models, Animal; Dopamine beta- | 2006 |
Ketogenic diet decreases circulating concentrations of neuroactive steroids of female rats.
Topics: Allylamine; Analysis of Variance; Animals; Animals, Newborn; Diet; Disease Models, Animal; Drug Comb | 2005 |
A comparison of the ability of a 4:1 ketogenic diet and a 6.3:1 ketogenic diet to elevate seizure thresholds in adult and young rats.
Topics: 3-Hydroxybutyric Acid; Age Factors; Animals; Blood Glucose; Body Weight; Dietary Fats; Disease Model | 2005 |
Thiol redox state and lipid and protein oxidation in the mouse striatum after pentylenetetrazol-induced epileptic seizure.
Topics: Animals; Corpus Striatum; Cysteine; Disease Models, Animal; Disulfides; Epilepsy; Glutathione; Lipid | 2005 |
Agmatine reduces extracellular glutamate during pentylenetetrazole-induced seizures in rat brain: a potential mechanism for the anticonvulsive effects.
Topics: Agmatine; Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Drug Interac | 2005 |
Isobolographic characterisation of interactions among selected newer antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model.
Topics: Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Disease Models, Animal | 2005 |
Involvement of prostaglandins in an animal model of Shigella-related seizures.
Topics: Animals; Chi-Square Distribution; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Disease Models | 2005 |
Anticonvulsant effects of 1,25-dihydroxyvitamin D in chemically induced seizures in mice.
Topics: Animals; Anticonvulsants; Brain; Calcitriol; Convulsants; Disease Models, Animal; Epilepsy; Injectio | 2005 |
Behavioural characterization in rats using the elevated alley Suok test.
Topics: Animals; Anxiety; Ataxia; Behavioral Research; Disease Models, Animal; Exploratory Behavior; Male; M | 2005 |
Preclinical profiling and safety studies of ABT-769: a compound with potential for broad-spectrum antiepileptic activity.
Topics: Abnormalities, Drug-Induced; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Disease Models, A | 2005 |
Pentylenetetrazole kindling induces neuronal cyclin B1 expression in rat hippocampus.
Topics: Animals; Behavior, Animal; Cell Count; Cell Death; Cyclin B; Cyclin B1; Disease Models, Animal; Dose | 2006 |
Spatial learning deficits and emotional impairments in pentylenetetrazole-kindled rats.
Topics: Affective Symptoms; Animals; Behavior, Animal; Convulsants; Disease Models, Animal; Hippocampus; Kin | 2005 |
Increased severity of chemically induced seizures in mice with partially deleted Vitamin D receptor gene.
Topics: Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Female; Mice; Mice, Knockout; P | 2006 |
Development of a pentylenetetrazole-induced seizure model to evaluate kinase inhibitor efficacy in the central nervous system.
Topics: Animals; Convulsants; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Enzyme Activation | 2006 |
Erythropoietin prevents the increase in blood-brain barrier permeability during pentylentetrazol induced seizures.
Topics: Animals; Blood-Brain Barrier; Capillary Permeability; Convulsants; Disease Models, Animal; Drug Anta | 2006 |
The acute anticonvulsant effects of deoxycorticosterone in developing rats: role of metabolites and mineralocorticoid-receptor responses.
Topics: Animals; Animals, Newborn; Anticonvulsants; Desoxycorticosterone; Disease Models, Animal; Enzyme Inh | 2005 |
Diphenyl diselenide and 2,3-dimercaptopropanol increase the PTZ-induced chemical seizure and mortality in mice.
Topics: Animals; Benzene Derivatives; Brain; Chelating Agents; Convulsants; Dimercaprol; Disease Models, Ani | 2006 |
Alterations in long-term seizure susceptibility and the complex of PSD-95 with NMDA receptor from animals previously exposed to perinatal hypoxia.
Topics: Animals; Animals, Newborn; Brain; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Disease M | 2006 |
The utility of testing pentylenetetrazol threshold.
Topics: Age Factors; Animals; Body Weight; Brain; Convulsants; Diet Therapy; Disease Models, Animal; Epileps | 2006 |
Repeated brief epileptic seizures by pentylenetetrazole cause neurodegeneration and promote neurogenesis in discrete brain regions of freely moving adult rats.
Topics: Animals; Brain; Cell Proliferation; Convulsants; Disease Models, Animal; Epilepsy; Female; GABA Anta | 2006 |
Deoxycorticosterone's anticonvulsant effects in infant rats are blocked by finasteride, but not by indomethacin.
Topics: Animals; Animals, Newborn; Anticonvulsants; Desoxycorticosterone; Disease Models, Animal; Dose-Respo | 2006 |
Region-specific loss of zinc in the brain in pentylentetrazole-induced seizures and seizure susceptibility in zinc deficiency.
Topics: Animals; Brain; Deficiency Diseases; Disease Models, Animal; Hippocampus; Male; Mice; Mice, Inbred S | 2006 |
Anticonvulsant action of allopregnanolone in immature rats.
Topics: Age Factors; Anesthetics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Injecti | 2006 |
Imaging the neural substrates involved in the genesis of pentylenetetrazol-induced seizures.
Topics: Animals; Brain Mapping; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy, Abs | 2006 |
Study of anticonvulsant effect of citronellol, a monoterpene alcohol, in rodents.
Topics: Action Potentials; Acyclic Monoterpenes; Analysis of Variance; Animals; Anticonvulsants; Disease Mod | 2006 |
Modulation of pentylenetetrazole-induced seizures and oxidative stress parameters by sodium valproate in the absence and presence of N-acetylcysteine.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Anticonvulsants; Antioxidants; Aspartate Aminotransfe | 2006 |
Altered seizure susceptibility in mice lacking the Ca(v)2.3 E-type Ca2+ channel.
Topics: 4-Aminopyridine; Animals; Blotting, Western; Calcium Channels; Calcium Channels, T-Type; Disease Mod | 2006 |
Anticonvulsant effect of Persea americana Mill (Lauraceae) (Avocado) leaf aqueous extract in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Disease Models, Animal; Dose-Response Relationsh | 2006 |
Effects of tianeptine on onset time of pentylenetetrazole-induced seizures in mice: possible role of adenosine A1 receptors.
Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Antidep | 2007 |
Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: Possible mechanism of action.
Topics: Animals; Anticonvulsants; Convulsants; Cyclooxygenase Inhibitors; Diazepam; Disease Models, Animal; | 2006 |
In vivo characterisation of the small-conductance KCa (SK) channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) as a potential anticonvulsant.
Topics: Animals; Anticonvulsants; Benzimidazoles; Disease Models, Animal; Dose-Response Relationship, Drug; | 2006 |
Additive effects of antiepileptic drugs and pentylenetetrazole on hearing.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Auditory Threshold; Convulsants; Disease Models, Ani | 2006 |
Epileptogenic drugs in a model nervous system: electrophysiological effects and incorporation into a phospholipid layer.
Topics: Action Potentials; Animals; Convulsants; Disease Models, Animal; Electric Stimulation; Epilepsy; Eto | 2006 |
Development of a Drosophila seizure model for in vivo high-throughput drug screening.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Behavior, Animal; Cell Survival; Convulsants; Disease | 2006 |
Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae).
Topics: Analysis of Variance; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Bicuculline; Choice Behav | 2006 |
Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis.
Topics: Animals; Anticonvulsants; Brain Chemistry; Clonazepam; Dioxolanes; Disease Models, Animal; Drug Inte | 2006 |
Pentylenetetrazole kindling affects sleep in rats.
Topics: Animals; Behavior, Animal; Convulsants; Disease Models, Animal; Dizocilpine Maleate; Electromyograph | 2006 |
Isobolographic characterization of interactions between vigabatrin and tiagabine in two experimental models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interaction | 2007 |
Evaluation of anticonvulsant and analgesic effects of benzyl- and benzhydryl ureides.
Topics: Analgesics; Animals; Anticonvulsants; Benzhydryl Compounds; Benzyl Compounds; Binding, Competitive; | 2007 |
Sex differences in modulating blood brain barrier permeability by NO in pentylenetetrazol-induced epileptic seizures.
Topics: Animals; Blood-Brain Barrier; Brain; Capillary Permeability; Convulsants; Disease Models, Animal; Dr | 2007 |
Dissociation between in vitro and in vivo epileptogenicity in a rat model of cortical dysplasia.
Topics: Animals; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy; Freezing; | 2007 |
Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome.
Topics: Animals; Behavior, Animal; Cognition Disorders; Disease Models, Animal; Down Syndrome; Electric Stim | 2007 |
Pentylenetetrazol-kindling in mice overexpressing heat shock protein 70.
Topics: Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Hippocampus; HSP70 H | 2007 |
The anticonvulsant activity of acetone, the major ketone body in the ketogenic diet, is not dependent on its metabolites acetol, 1,2-propanediol, methylglyoxal, or pyruvic acid.
Topics: Acetone; Animals; Anticonvulsants; Diet Therapy; Disease Models, Animal; Epilepsy; Ketone Bodies; Ma | 2007 |
Effect of pentobarbital on pH and electrolyte levels after induced seizure in rats.
Topics: Animals; Anticonvulsants; Calcium; Carbamazepine; Disease Models, Animal; Drug Interactions; Electro | 2007 |
[Long-term effects of recurrent seizures in neonate period on gamma-aminobutyric acid A receptor alpha1 and beta2 subunits expression in adult brain: experiment with rats].
Topics: Animals; Animals, Newborn; Brain; Cerebral Cortex; Disease Models, Animal; Flurothyl; Hippocampus; I | 2007 |
Effects of postnatal caffeine exposure on seizure susceptibility in developing rats.
Topics: Age Factors; Aminophylline; Animals; Animals, Newborn; Behavior, Animal; Bicuculline; Caffeine; Cent | 2007 |
Thalidomide inhibits pentylenetetrazole-induced seizures.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Respo | 2007 |
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Axons; Convulsant | 2007 |
Zebrafish offer the potential for a primary screen to identify a wide variety of potential anticonvulsants.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug | 2007 |
Role of ATP-sensitive potassium channels in the biphasic effects of morphine on pentylenetetrazole-induced seizure threshold in mice.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Blood Glucose; Cromakalim; Disease Models, Animal | 2007 |
Mirtazapine does not affect pentylenetetrazole- and maximal electroconvulsive shock-induced seizures in mice.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Chi-Square Distribution; Depressive | 2007 |
A large-scale mutagenesis screen to identify seizure-resistant zebrafish.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Genetic Predisposition to Disease; Genetic Testin | 2007 |
Neuroprotective effect of nimesulide, a preferential COX-2 inhibitor, against pentylenetetrazol (PTZ)-induced chemical kindling and associated biochemical parameters in mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Chemistry; Cyclooxygenase Inhibitors; Disease | 2007 |
Modafinil exerts a dose-dependent antiepileptic effect mediated by adrenergic alpha1 and histaminergic H1 receptors in mice.
Topics: Animals; Benzhydryl Compounds; Disease Models, Animal; Electroencephalography; Electroshock; Epileps | 2007 |
Pharmacological modulation of anxiety-related behaviors in the murine Suok test.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Circadian Rhythm; Diazepam; Disease Models, | 2007 |
Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors.
Topics: Animals; Anticonvulsants; Antidotes; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Re | 2007 |
Drug treatment improves memory in mice.
Topics: Animals; Central Nervous System Stimulants; Chromosomes, Human, Pair 21; Cyclopentanes; Disease Mode | 2007 |
Effect of systemic administration of adenosine on brain adenosine levels in pentylenetetrazol-induced seizure threshold in mice.
Topics: Adenosine; Analysis of Variance; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, | 2007 |
Elevation of pentylenetetrazole-induced seizure threshold in cholestatic mice: interaction between opioid and cannabinoid systems.
Topics: Animals; Anticonvulsants; Bile Ducts; Cannabinoid Receptor Modulators; Cholestasis; Disease Models, | 2008 |
On the anticonvulsant activity of kaurenic acid.
Topics: Animals; Anticonvulsants; Bufo marinus; Cold Temperature; Disease Models, Animal; Diterpenes; Drug E | 2007 |
Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Ant | 2007 |
Calorie-restricted ketogenic diet increases thresholds to all patterns of pentylenetetrazol-induced seizures: critical importance of electroclinical assessment.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Body Weight; Caloric Restriction; Cerebral Cortex; Di | 2008 |
Anticonvulsant action of GABA-B receptor agonist SKF97541 differs from that of baclofen.
Topics: Age Factors; Animals; Anticonvulsants; Baclofen; Disease Models, Animal; Dose-Response Relationship, | 2008 |
Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor increases pentylenetetrazol seizure threshold in mice: possible involvement of adenosinergic mechanism.
Topics: Adenine; Adenosine; Analysis of Variance; Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Anim | 2008 |
Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesis.
Topics: Animals; Brain Injuries; Cerebral Cortex; Convulsants; Diffusion Magnetic Resonance Imaging; Disease | 2007 |
Anticonvulsant property of Sutherlandia frutescens R. BR. (variety Incana E. MEY.) [Fabaceae] shoot aqueous extract.
Topics: Analysis of Variance; Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response R | 2008 |
Seizure susceptibility alteration following reversible cholestasis in mice: Modulation by opioids and nitric oxide.
Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Bilirubin; Biomarkers; Cholestasis; Corn Oi | 2008 |
[Changes of mossy fiber sprouting in hippocampus of pentylenetetrazole kindling rats].
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Mossy Fibers, Hi | 2007 |
Dose dependent effects of ghrelin on pentylenetetrazole-induced oxidative stress in a rat seizure model.
Topics: Animals; Brain; Disease Models, Animal; Ghrelin; Liver; Oxidative Stress; Pentylenetetrazole; Rats; | 2008 |
Sedative and anticonvulsant effects of zolpidem in adult and aged mice.
Topics: Age Factors; Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Disease Models, Animal; Dose-Re | 2008 |
Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome.
Topics: Acetylcholine; Animals; Brain; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Disease Mod | 2008 |
Effects of gamma-decanolactone on seizures induced by PTZ-kindling in mice.
Topics: Animals; Anticonvulsants; Brain; Comet Assay; Convulsants; Disease Models, Animal; DNA Damage; Dose- | 2008 |
Deficiency of neural cell adhesion molecule or its polysialylation modulates pharmacological effects of the AMPA receptor antagonist NBQX.
Topics: Analysis of Variance; Animals; Ataxia; Behavior, Animal; Disease Models, Animal; Excitatory Amino Ac | 2008 |
Behavioral characterization of pentylenetetrazol-induced seizures in the marmoset.
Topics: Animals; Behavior, Animal; Callithrix; Disease Models, Animal; Dose-Response Relationship, Drug; Fem | 2008 |
Rofecoxib potentiates the anticonvulsant effect of topiramate.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; | 2008 |
Somatostatin receptor subtype 4 couples to the M-current to regulate seizures.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Radiation; Electr | 2008 |
Antiepileptic effects of electroacupuncture vs vagus nerve stimulation on cortical epileptiform activities.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Dose-Respon | 2008 |
Morphological and functional changes of blood-brain barrier in kindled rats with cortical dysplasia.
Topics: Animals; Blood-Brain Barrier; Capillary Permeability; Disease Models, Animal; Female; Glial Fibrilla | 2008 |
Antioxidants and free radical scavengers do not consistently delay seizure onset in animal models of acute seizures.
Topics: Acute Disease; Animals; Antioxidants; Behavior, Animal; Disease Models, Animal; Dose-Response Relati | 2008 |
Antiseizure effects of 5*-androstane-3*,7beta-diol may be independent of actions at estrogen receptor beta.
Topics: Androstane-3,17-diol; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Estrogen R | 2008 |
Synthesis and preliminary evaluation of some substituted coumarins as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Coumarins; Disease Models, Animal; Dose-Response Relationship, Drug; Male; | 2008 |
Glutamine synthetase becomes nitrated and its activity is reduced during repetitive seizure activity in the pentylentetrazole model of epilepsy.
Topics: Animals; Astrocytes; Brain; Disease Models, Animal; Epilepsy; Gene Expression Regulation; Glial Fibr | 2008 |
Evidence for the involvement of the adenosine A(2A) receptor in the lowered susceptibility to pentylenetetrazol-induced seizures produced in mice by long-term treatment with caffeine.
Topics: Analysis of Variance; Animals; Caffeine; Disease Models, Animal; Disease Susceptibility; Dose-Respon | 2008 |
Comparison of the actions of trimethadione and chlordiazepoxide in animal models of anxiety and benzodiazepine receptor binding.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Chlordiazepoxide; Conflict, Psychological; | 1982 |
A model of chronic spontaneous petit mal-like seizures in the rat: comparison with pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalo | 1984 |
Status epilepticus and brain maturation.
Topics: Animals; Animals, Newborn; Brain; Disease Models, Animal; Electroencephalography; Epilepsies, Partia | 1984 |
Glycine potentiates the action of some anticonvulsant drugs in some seizure models.
Topics: 3-Mercaptopropionic Acid; Acoustic Stimulation; Animals; Anticonvulsants; Disease Models, Animal; Dr | 1984 |
The effect of spontaneous seizures on pentylenetetrazole and maximum electroshock induced seizures in the Mongolian gerbil.
Topics: Animals; Disease Models, Animal; Electroshock; Endorphins; Epilepsy; Female; Gerbillinae; Male; Mode | 1984 |
The pentylenetetrazol model of anxiety detects withdrawal from diazepam in rats.
Topics: Animals; Anxiety; Diazepam; Discrimination Learning; Disease Models, Animal; Humans; Male; Pentylene | 1983 |
Changes in response to metrazole during fever in juvenile rats; a new model for febrile convulsions?
Topics: Animals; Body Temperature Regulation; Disease Models, Animal; Male; Pentylenetetrazole; Rats; Rats, | 1984 |
Neural mechanisms in cardiac arrhythmias associated with epileptogenic activity: the effect of phenobarbital in the cat.
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Blood Pressure; Cats; Disease Models, Anima | 1984 |
Convulsant-specific architecture of the postictal behavior syndrome in the rat.
Topics: Animals; Behavior, Animal; Benzodiazepinones; Catatonia; Convulsants; Disease Models, Animal; Electr | 1981 |
Potentiation of hyperthermia-induced convulsions in the developing rat by previous treatment with pentylenetetrazol.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Male; Pentylenetetrazole; Rats; Rats, Inbre | 1983 |
Post-ictal locomotor activity in three different rat models of epilepsy.
Topics: Amygdala; Animals; Disease Models, Animal; Electroshock; Kindling, Neurologic; Male; Motor Activity; | 1982 |
Baclofen as an anticonvulsant in experimental models of convulsions.
Topics: 3-Mercaptopropionic Acid; Acoustic Stimulation; Animals; Baclofen; Disease Models, Animal; Dose-Resp | 1981 |
Antagonism of experimentally induced tonic seizures following a lesion in the midbrain tegmentum.
Topics: Animals; Disease Models, Animal; Electroshock; Flurothyl; Hindlimb; Male; Muscles; Pentylenetetrazol | 1981 |
Anticonvulsant properties of two new 3,3-diethyl-2,4-pyridinedione derivatives. I. Effects in two experimental models of generalized epilepsy in cats.
Topics: Animals; Anticonvulsants; Brain; Cats; Disease Models, Animal; Pentylenetetrazole; Pyridones; Seizur | 1981 |
The anticonvulsant effects of diazepam and phenobarbital in prekindled and kindled cortical seizures.
Topics: Amygdala; Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Disease Models, Animal; Epilepsy; Mal | 1981 |
Requirements for an ideal alcohol antagonist.
Topics: Alcoholic Intoxication; Animals; Caffeine; Cats; Dextroamphetamine; Disease Models, Animal; Dogs; Et | 1980 |
Characterization of the antiabsence effects of SCH 50911, a GABA-B receptor antagonist, in the lethargic mouse, gamma-hydroxybutyrate, and pentylenetetrazole models.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Electroencephalography; Epilepsy | 1995 |
Withdrawal-like effects of pentylenetetrazol and valproate in the naive organism: a model of motivation produced by opiate withdrawal?
Topics: Animals; Avoidance Learning; Conditioning, Classical; Disease Models, Animal; Dose-Response Relation | 1995 |
Anticonvulsant activity of Casimiroa edulis in comparison to phenytoin and phenobarbital.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Injections, Su | 1995 |
Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Age | 1993 |
Further evidence for the interactions between angiotensin II and GABAergic transmission in pentylenetetrazol kindling seizures in mice.
Topics: Angiotensin II; Animals; Baclofen; Disease Models, Animal; Dose-Response Relationship, Drug; Drug In | 1995 |
An animal model for the study of neurotoxicity of bacterial products and application of the model to demonstrate that Shiga toxin and lipopolysaccharide cooperate in inducing neurologic disorders.
Topics: Animals; Bacterial Toxins; Disease Models, Animal; Escherichia coli; Lipopolysaccharides; Male; Mice | 1995 |
[Increase in sensitivity of mice to a convulsant after adoptive transfer of splenocytes from mice, subjected to corazole kindling].
Topics: Animals; Cell Transplantation; Convulsants; Disease Models, Animal; Epilepsy; Immunotherapy, Adoptiv | 1995 |
The activity of opioid analgesics in seizure models utilizing N-methyl-DL-aspartic acid, kainic acid, bicuculline and pentylenetetrazole.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Bicuculline; Convulsants; Disease Models, Animal; Dose | 1994 |
NMDA-GABA interactions in an animal model of behaviour: a gating mechanism from motivation toward psychotic-like symptoms.
Topics: Alprazolam; Animals; Behavior, Animal; Desipramine; Disease Models, Animal; Dizocilpine Maleate; gam | 1994 |
Pharmacological studies on a new dihydrothienopyridine calcium antagonist, S-312-d. 5th communication: anticonvulsant effects in mice.
Topics: Administration, Oral; Animals; Anticonvulsants; Bemegride; Calcium Channel Blockers; Dihydropyridine | 1994 |
Dexmedetomidine decreases seizure threshold in a rat model of experimental generalized epilepsy.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Disease Models, Animal; Dose-Respo | 1994 |
gamma Aminobutyric acid mediation of the anticonvulsant effect of clonidine on pentylenetetrazol-induced seizures in mice.
Topics: Animals; Clonidine; Disease Models, Animal; gamma-Aminobutyric Acid; Mice; Pentylenetetrazole; Seizu | 1994 |
A piglet model of status epilepticus: comparison of cardiorespiratory and metabolic changes with two methods of pentylenetetrazol administration.
Topics: Animals; Disease Models, Animal; Hemodynamics; Infusions, Intravenous; Pentylenetetrazole; Status Ep | 1994 |
Intravenous versus intramuscular midazolam in treatment of chemically induced generalized seizures in swine.
Topics: Animals; Disease Models, Animal; Injections, Intramuscular; Injections, Intravenous; Midazolam; Pent | 1994 |
[Development of pentylenetetrazol kindling model].
Topics: Animals; Disease Models, Animal; Epilepsy; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rat | 1993 |
Intermittent clonazepam treatment prevents anticonvulsant tolerance in mice.
Topics: Animals; Clonazepam; Disease Models, Animal; Drug Administration Schedule; Drug Tolerance; Epilepsy; | 1993 |
Anxiogenic effect of disulfiram evaluated in an animal model.
Topics: Acetaldehyde; Animals; Appetitive Behavior; Arousal; Conditioning, Operant; Discrimination Learning; | 1993 |
Models of simple partial and absence seizures in freely moving rats: action of ketamine.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalo | 1993 |
[The effect of superoxide dismutase on seizures in an experimental rat model of epilepsy].
Topics: Animals; Convulsants; Disease Models, Animal; Electric Stimulation; Electroencephalography; Kindling | 1995 |
Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis: III. The action of kynurenic acid and glutamic acid diethylester.
Topics: Age Factors; Animals; Disease Models, Animal; Glutamic Acid; Kynurenic Acid; Male; Pentylenetetrazol | 1995 |
Chronic malnutrition caused by a corn-based diet lowers the threshold for pentylenetetrazol-induced seizures in rats.
Topics: Animals; Body Weight; Brain; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Female; | 1996 |
Effects of an ethanolic extract of Desmodium adscendens on central nervous system in rodents.
Topics: Acetates; Acetic Acid; Analgesics; Analysis of Variance; Animals; Anticonvulsants; Body Temperature; | 1996 |
Alterations of neuronal fibers after epileptic activity induced by pentylenetetrazole: fine structure investigated by calcium cytochemistry and neurobiotin labeling (buccal ganglia, Helix pomatia).
Topics: Animals; Biotin; Calcium; Cheek; Dendrites; Disease Models, Animal; Electrophysiology; Epilepsy; Gan | 1996 |
Increased protein kinase C isoform gamma in the hippocampus of pentylenetetrazol-induced chemoshocked mouse.
Topics: Animals; Blotting, Western; Cerebral Cortex; Disease Models, Animal; Hippocampus; Male; Mice; Mice, | 1996 |
The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. VI. Seasonal influences on maximal electroshock and pentylenetetrazol seizure thresholds.
Topics: Animals; Anticonvulsants; Circadian Rhythm; Disease Models, Animal; Electroshock; Epilepsy; Male; Mi | 1996 |
The model of pentylenetetrazol-induced status epilepticus in the immature rat: short- and long-term effects.
Topics: Animals; Brain; Cerebral Cortex; Cerebrovascular Circulation; Disease Models, Animal; Female; Glucos | 1996 |
Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Dizocilpine Maleate; Drug I | 1997 |
Strain differences in pentylenetetrazol-kindling development and subsequent potentiation effects.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy; Glutamic Acid; Kindling, Neurologic; Male; P | 1997 |
Fos in locus coeruleus neurons following audiogenic seizure in the genetically epilepsy-prone rat: comparison to electroshock and pentylenetetrazol seizure models.
Topics: Animals; Disease Models, Animal; Electroshock; Epilepsy; Female; Locus Coeruleus; Pentylenetetrazole | 1997 |
A comparative study of aminophylline- and acepifylline-induced seizures and death in the chemoconvulsion model in rats.
Topics: Aminophylline; Animals; Bronchodilator Agents; Convulsants; Disease Models, Animal; Drug Interaction | 1997 |
A discriminative stimulus produced by 1-(3-chlorophenyl)-piperazine (mCPP) as a putative animal model of anxiety.
Topics: Animals; Anxiety Disorders; Discrimination Learning; Disease Models, Animal; Dose-Response Relations | 1998 |
Ontogeny of ethosuximide action against two seizure models in rats is different.
Topics: Action Potentials; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Ethosux | 1998 |
Deficient sensorimotor gating following seizures in amygdala-kindled rats.
Topics: Acoustic Stimulation; Amygdala; Analysis of Variance; Animals; Cues; Disease Models, Animal; Electri | 1998 |
A primate model of anxiety.
Topics: Animals; Anxiety; Behavior, Animal; Benzodiazepines; Disease Models, Animal; Hydrocortisone; Macaca | 1998 |
Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbolines; Convulsants; Diazepam; Disease Mod | 1998 |
Additive anticonvulsant effect of flunarizine and sodium valproate on electroshock and chemoshock induced seizures in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Drug Synergism; | 1998 |
Antiepileptic effects of NPY on pentylenetetrazole seizures.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Humans; Injections, Intraventricular; | 1998 |
[Influence of co-administered antiepileptic drugs on nitrazepam tolerance in mice].
Topics: Animals; Anticonvulsants; Benzodiazepines; Disease Models, Animal; Drug Interactions; Drug Therapy, | 1998 |
A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat.
Topics: 3-Hydroxybutyric Acid; Animals; Dietary Carbohydrates; Dietary Fats; Disease Models, Animal; Epileps | 1999 |
Evaluation of the anticonvulsant activity of the essential oil of Eugenia caryophyllata in male mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electric Stimulation; Evaluation Studies as Topic; | 1999 |
Absence epilepsy and regional blood-brain barrier permeability: the effects of pentylenetetrazole-induced convulsions.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Epilepsy, Absence; Male; Pentylenetetrazole; P | 1999 |
Anticonvulsant properties of linalool in glutamate-related seizure models.
Topics: Acyclic Monoterpenes; Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Dizocilpine | 1999 |
Anticonvulsant activity of paeonimetabolin-I adducts obtained by incubation of paeoniflorin and thiol compounds with Lactobacillus brevis.
Topics: Analysis of Variance; Animals; Anticonvulsants; Benzoates; Bridged-Ring Compounds; Disease Models, A | 1999 |
Reversal by flunarizine of the decrease in hippocampal acetylcholine release in pentylenetetrazole-kindled rats.
Topics: Acetylcholine; Analysis of Variance; Animals; Anticonvulsants; Calcium; Convulsants; Disease Models, | 1999 |
Increased sensitivity to seizures in mice lacking cellular prion protein.
Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Kindling, Neurologic; Male; Mice; Mice, Knoc | 1999 |
The anticonvulsant activities of N-benzyl 3-methoxypropionamides.
Topics: Acetamides; Amides; Animals; Anticonvulsants; Disease Models, Animal; Lacosamide; Mice; Pentylenetet | 1999 |
Effect of sodium valproate and flunarizine administered alone and in combination on pentylenetetrazole model of absence seizures in rat.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Synergism; Electroencephalography; Epilepsy, | 1999 |
A major effect QTL determined by multiple genes in epileptic EL mice.
Topics: Alleles; Animals; Disease Models, Animal; Epilepsy; Female; Genetic Markers; Homozygote; Male; Mice; | 2000 |
Role of nitric oxide in pentylenetetrazol-induced seizures: age-dependent effects in the immature rat.
Topics: Age Factors; Animals; Animals, Newborn; Arginine; Brain; Catalysis; Disease Models, Animal; Electroe | 2000 |
Effect of shitei-to, a traditional Chinese medicine formulation, on pentylenetetrazol-induced kindling in mice.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Drugs, Chinese Herbal; Kindling, Neur | 2000 |
TS+OCD-like neuropotentiated mice are supersensitive to seizure induction.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Humans; Limbic System; Male; Mice; Mice, Inbred BA | 2000 |
Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Bicuculline; Convulsants; Disease Model | 2000 |
Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Enzyme Inhibitors; Epilepsy | 2000 |
Effects of compounds acting on GABA(B) receptors in the pentylenetetrazole kindling model of epilepsy in mice.
Topics: Animals; Cerebral Cortex; Convulsants; Disease Models, Animal; Epilepsy; GABA Antagonists; GABA-B Re | 2000 |
Reduction of pentylenetetrazole-induced seizure activity in awake rats by seizure-triggered trigeminal nerve stimulation.
Topics: Animals; Cerebral Cortex; Cortical Synchronization; Disease Models, Animal; Electric Stimulation The | 2000 |
Anticonvulsant action of topiramate against motor seizures in developing rats.
Topics: Age Factors; Animals; Anticonvulsants; Behavior, Animal; Brain; Disease Models, Animal; Epilepsy, Ge | 2000 |
Two different anticonvulsant actions of tiagabine in developing rats.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Dose-Respons | 2000 |
Chemical kindling and seizure susceptibility in morphine dependent rats.
Topics: Animals; Caffeine; Convulsants; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Ago | 2000 |
7-Nitroindazole, a nitric oxide synthase inhibitor, enhances the anticonvulsive action of ethosuximide and clonazepam against pentylenetetrazol-induced convulsions.
Topics: Animals; Anticonvulsants; Avoidance Learning; Clonazepam; Disease Models, Animal; Drug Interactions; | 2000 |
Post-ictal analgesia: involvement of opioid, serotoninergic and cholinergic mechanisms.
Topics: Analgesia; Animals; Atropine; Convulsants; Disease Models, Animal; Injections, Intraperitoneal; Keta | 2001 |
Comparative profiles of sodium valproate and ethosuximide on electro-behavioural correlates in gamma-hydroxybutyrate and pentylenetetrazol induced absence seizures in rats.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Abs | 2000 |
Experiments in the rat pentylenetetrazole infusion threshold model of the ketogenic diet.
Topics: Age Factors; Animals; Convulsants; Dietary Carbohydrates; Dietary Proteins; Disease Models, Animal; | 2001 |
Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepinones; Desoxycorticosterone; Diazepam; | 2001 |
Neurosteroid withdrawal model of perimenstrual catamenial epilepsy.
Topics: 20-alpha-Dihydroprogesterone; Adult; Animals; Behavior, Animal; Disease Models, Animal; Disease Susc | 2001 |
Anticonvulsant profile of valrocemide (TV1901): a new antiepileptic drug.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Respo | 2001 |
Physiological and structural evidence for hippocampal involvement in persistent seizure susceptibility after traumatic brain injury.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Injuries; Cell Count; Cell Death; Chronic Disease; Denta | 2001 |
Nociceptin, OP4 receptor ligand in different models of experimental epilepsy.
Topics: Animals; Bicuculline; Disease Models, Animal; Electric Stimulation; Epilepsy; Female; Mice; N-Methyl | 2002 |
The additive effect of opioids and nitric oxide in increasing pentylenetetrazole-induced seizure threshold in cholestatic mice.
Topics: Animals; Cholestasis; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Male; M | 2002 |
The effects of ACTH and adrenocorticosteroids on seizure susceptibility in 15-day-old male rats.
Topics: Adrenocorticotropic Hormone; Aldosterone; Animals; Corticosterone; Dehydroepiandrosterone; Desoxycor | 2002 |
Ethopharmacological analysis of the unstable elevated exposed plus maze, a novel model of extreme anxiety: predictive validity and sensitivity to anxiogenic agents.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Caffeine; Ca | 2002 |
Protective effect of resveratrol against pentylenetetrazole-induced seizures and its modulation by an adenosinergic system.
Topics: Adenosine; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug | 2002 |
Attempts to produce spike-and-wave complexes in the electrocorticogram of the rat.
Topics: Animals; Cerebral Cortex; Cobalt; Disease Models, Animal; Electrodes, Implanted; Electroencephalogra | 1975 |
[The dual role of the caudate nucleus in regulating seizures].
Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Brain Mapping; Cats; Caudate Nucleus; Cerebral | 1975 |
The effects of d-amphetamine and temperature on p-cresol and pentylenetetrazol induced convulsions.
Topics: Animals; Body Weight; Cresols; Dextroamphetamine; Disease Models, Animal; Dose-Response Relationship | 1977 |
The photically evoked afterdischarge: a model for the study of drugs useful in the treatment of petit mal epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Absence; Evoked Potentials; Female; Pent | 1976 |
Brain function in epilepsy: midbrain, medullary, and cerebellar interaction with the rostral forebrain.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Cobalt; Disease Models, Animal; Electric Stimulation; E | 1976 |
Cerebral permeability phenomena in epilepsy.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Cell Membrane Permeability; Disease Models, Animal; Extr | 1976 |
Four models for studying cerebral lesions secondary to epileptic seizures.
Topics: Animals; Astrocytes; Bicuculline; Blood Gas Analysis; Blood Glucose; Blood Pressure; Body Temperatur | 1975 |
Effects of acute and chronic paleocerebellar stimulation on experimental models of epilepsy in the cat: studies with enflurane, pentylenetetrazol, penicillin, and chloralose.
Topics: Acoustic Stimulation; Animals; Cats; Cerebellum; Chloralose; Disease Models, Animal; Electric Stimul | 1975 |
Generality of the kindling phenomenon: some clinical implications.
Topics: Alcoholism; Animals; Disease Models, Animal; Humans; Male; Pentylenetetrazole; Rats; Seizures; Subst | 1975 |
Influence of phenobarbital on ECoG phenomena induced by metrazol in rats during ontogenesis.
Topics: Aging; Animals; Cerebral Cortex; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Dru | 1992 |
[The antiepileptic effects of sodium valproate and the calcium antagonist riodipine when used jointly in a model of generalized korazol-induced epileptic activity].
Topics: Animals; Calcium Channel Blockers; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Ev | 1992 |
An experimental model of generalized seizures for the measurement of local cerebral glucose utilization in the immature rat. I. Behavioral characterization and determination of lumped constant.
Topics: Aging; Animals; Blood Glucose; Brain; Disease Models, Animal; Female; Glucose; Kinetics; Lactates; M | 1992 |
An experimental model of generalized seizures for the measurement of local cerebral glucose utilization in the immature rat. II. Mapping of brain metabolism using the quantitative [14C]2-deoxyglucose technique.
Topics: Aging; Animals; Autoradiography; Blood Glucose; Brain; Brain Mapping; Carbon Radioisotopes; Deoxyglu | 1992 |
The detection of changes in psychological state using a novel pharmacological conditioning procedure.
Topics: Animals; Anxiety; Cues; Discrimination Learning; Disease Models, Animal; Male; Pentylenetetrazole; R | 1992 |
Pentylenetetrazole can induce a conditioned place preference.
Topics: Animals; Anxiety; Conditioning, Classical; Discrimination Learning; Disease Models, Animal; Male; Pe | 1991 |
Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia.
Topics: Animals; Baclofen; Carbamazepine; Cricetinae; Diazepam; Disease Models, Animal; Dystonia; gamma-Amin | 1991 |
[Correlations of convulsive and hypoxic resistance in rats at different stages of ontogenesis].
Topics: Age Factors; Animals; Animals, Newborn; Atmosphere Exposure Chambers; Disease Models, Animal; Diseas | 1991 |
[Qualitative and quantitative changes in phospholipid spectra of the brain of rats with corazol-induced epilepsy].
Topics: Animals; Cerebellum; Cerebral Cortex; Chromatography, Thin Layer; Disease Models, Animal; Epilepsy; | 1991 |
Effect of gamma-crotonolactone in experimental models of generalized absence seizures.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Furans; M | 1991 |
Effects of vinburnine on experimental models of learning and memory impairments.
Topics: Amnesia, Retrograde; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Learning Dis | 1990 |
An examination of the proconvulsant actions of pyrethroid insecticides using pentylenetetrazol and amygdala kindling seizure models.
Topics: Amygdala; Animals; Convulsants; Disease Models, Animal; Injections, Intraperitoneal; Injections, Int | 1990 |
Anxiogenic effects of drug withdrawal.
Topics: Animals; Anxiety; Disease Models, Animal; Humans; Pentylenetetrazole; Psychotropic Drugs; Rats; Subs | 1989 |
Animal models for the study of anti-anxiety agents: a review.
Topics: Aggression; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Behavior, Animal; Cats; Condi | 1985 |
Bidirectional modulation of GABA function by beta-carbolines.
Topics: Acoustic Stimulation; Anesthesia, General; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning | 1986 |
Withdrawal from diazepam substitutes for the discriminative stimulus properties of pentylenetetrazol.
Topics: Animals; Diazepam; Discrimination Learning; Disease Models, Animal; Flumazenil; Male; Pentylenetetra | 1988 |
Animal model for evaluating the convulsive liability of beta-lactam antibiotics.
Topics: Animals; Anti-Bacterial Agents; beta-Lactams; Binding, Competitive; Cefazolin; Cilastatin; Cilastati | 1988 |
Hyperbaric oxygen induced experimental epilepsy: the age factor.
Topics: Aging; Animals; Disease Models, Animal; Epilepsy; Hyperbaric Oxygenation; Male; Mice; Mice, Inbred S | 1986 |
Searching for models of Alzheimer's disease: a comparison of four amnestic treatments in two behavioral tasks.
Topics: Acetylcholine; Age Factors; Alzheimer Disease; Animals; Avoidance Learning; Behavior, Animal; Discri | 1985 |
A timed intravenous pentylenetetrazol infusion seizure model for quantitating the anticonvulsant effect of valproic acid in the rat.
Topics: Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Infusions, Parenteral; Mal | 1985 |
EEG effects of i.v. infusion of pentylenetetrazol in rats: a model for screening and classifying antiepileptic compounds.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Electroencephalograp | 1985 |
Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Ele | 1986 |
Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Female; gamma-Aminobutyric Acid; Ger | 1985 |
Patterns of cortical population discharges during metrazol-induced seizures in cats.
Topics: Animals; Cats; Cerebral Cortex; Computers; Cortical Synchronization; Disease Models, Animal; Electri | 1972 |
An electronic device for continuous counting of chemically induced epileptic discharges.
Topics: Action Potentials; Animals; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epileps | 1974 |
Generalized penicillin epilepsy in the cat: effects of intracarotid and intravertebral pentylenetetrazol and amobarbital injections.
Topics: Amobarbital; Animals; Brain Stem; Carotid Arteries; Cats; Cerebral Cortex; Disease Models, Animal; E | 1974 |
Connections between EEG activity and post-synaptic potentials of spinal motoneurones during convulsions.
Topics: Animals; Carbon Dioxide; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Evoked Pot | 1970 |
Isolated head of the turtle- a useful experimental model in the physiology and pathophysiology of the brain.
Topics: Animals; Brain; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Electroencephalograph | 1973 |
[Neurophysiologic models of epilepsy].
Topics: Action Potentials; Animals; Brain; Cats; Cell Membrane Permeability; Cold Temperature; Cortical Spre | 1972 |
Differential effects of pentylenetetrazol on REM sleep in naive and cobalt-epileptic rats.
Topics: Animals; Cerebral Cortex; Cobalt; Disease Models, Animal; Electroencephalography; Electromyography; | 1974 |
Experimental temporal lobe epilepsy.
Topics: Aluminum Hydroxide; Animals; Brain; Disease Models, Animal; Electroencephalography; Epilepsy, Tempor | 1974 |
Persistent seizure susceptibility and recurrent spontaneous seizures in kindled cats.
Topics: Amygdala; Animals; Cats; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Electrodes, | 1974 |
Cobalt experimental epilepsy in various strains of rat.
Topics: Animals; Cerebral Cortex; Cobalt; Cricetinae; Disease Models, Animal; Epilepsy; Gerbillinae; Guinea | 1973 |
Anticonvulsant effects of uridine: comparative analysis of metrazol and penicillin induced foci.
Topics: Animals; Anticonvulsants; Anura; Autoradiography; Cerebral Cortex; Disease Models, Animal; Electroen | 1973 |
Anticonvulsive action of increased calcium concentration in cerebrospinal fluid.
Topics: Acetylcholine; Animals; Anticonvulsants; Calcium; Cats; Disease Models, Animal; Dose-Response Relati | 1973 |
Cerebral energy metabolism and the regulation of cerebral blood flow.
Topics: Adenosine Triphosphate; Animals; Brain; Carbon Dioxide; Cerebrovascular Circulation; Disease Models, | 1973 |
Brain-stem and cortical mechanisms in an animal model of generalized corticoreticular epilepsy.
Topics: Amobarbital; Animals; Arousal; Brain Stem; Cats; Cerebral Cortex; Cortical Synchronization; Disease | 1973 |
Activity of alpha and gamma extensor motor axons during metrazol-induced seizures in cat.
Topics: Action Potentials; Animals; Cats; Cerebral Decortication; Disease Models, Animal; Electroencephalogr | 1974 |
Seizure inhibition by median raphe nucleus stimulation in rat.
Topics: Amygdala; Animals; Disease Models, Animal; Electric Stimulation; Electroencephalography; Epilepsy; E | 1974 |
Extrasynaptic mechanisms of Cardiazol-induced epileptiform activity of invertebrate neurons.
Topics: Action Potentials; Animals; Calcium; Disease Models, Animal; Electric Stimulation; Epilepsy; Ganglia | 1974 |
Experimental petit mal.
Topics: Aluminum; Amygdala; Animals; Brain; Caudate Nucleus; Disease Models, Animal; Electroencephalography; | 1967 |
Seizure induction by pentylenetetrazol in rodents receiving Candida albicans glycoprotein orally.
Topics: Administration, Oral; Animals; Candida; Disease Models, Animal; Drug Synergism; Female; Glycoprotein | 1971 |
Studies on neurochemical changes in experimental epilepsy.
Topics: Allyl Compounds; Aminobutyrates; Animals; Biogenic Amines; Brain Chemistry; Carboxy-Lyases; Cerebral | 1971 |
[Effect of coumarin from Melilotus officinalis on the convulsion threshold of the central nervous system in rats and guinea pigs].
Topics: Animals; Coumarins; Disease Models, Animal; Guinea Pigs; Isoniazid; Pentylenetetrazole; Plant Extrac | 1970 |