pentylenetetrazole has been researched along with Disease Exacerbation in 12 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pentylenetetrazole (PTZ)-induced seizures in Zebrafish models are now widely accepted for investigating human disease epilepsy." | 7.88 | Gastrodin Suppresses Pentylenetetrazole-Induced Seizures Progression by Modulating Oxidative Stress in Zebrafish. ( Cui, Y; Han, L; He, Q; Jin, M; Liu, K; Zhang, S, 2018) |
| "Pentylenetetrazole (PTZ)-induced seizures in Zebrafish models are now widely accepted for investigating human disease epilepsy." | 3.88 | Gastrodin Suppresses Pentylenetetrazole-Induced Seizures Progression by Modulating Oxidative Stress in Zebrafish. ( Cui, Y; Han, L; He, Q; Jin, M; Liu, K; Zhang, S, 2018) |
| " Epileptic rats that developed spontaneous recurrent seizures after a pilocarpine-induced status epilepticus were treated with a KD or control diet (CD)." | 3.81 | Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats. ( Akula, KK; Boison, D; Coffman, SQ; Lusardi, TA; Masino, SA; Ruskin, DN, 2015) |
| "We have previously reported that an episode of pentylenetetrazole (PTZ)-induced status epilepticus (SE) in immature rats induces a long-term increase in cholinergic excitation assessed in the adult brain in vitro." | 3.80 | A single episode of juvenile status epilepticus reduces the threshold to adult seizures in a stimulus-specific way. ( Kouis, P; Mikroulis, A; Psarropoulou, C, 2014) |
| "In rodent seizure models, tanshinone IIA showed anticonvulsive activity in the mouse 6-Hz psychomotor seizure test in a biphasic manner and modified seizure thresholds in a complex manner for the mouse i." | 1.39 | Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models. ( Buenafe, OE; Crawford, AD; De Borggraeve, W; de Witte, P; Esguerra, CV; Huang, H; Luyten, W; Maes, J; Orellana-Paucar, A; Ying, X, 2013) |
| "A clonic-tonic seizure episode was induced by a single i." | 1.39 | A single pentylenetetrazole-induced clonic-tonic seizure episode is accompanied by a slowly developing cognitive decline in rats. ( Aniol, VA; Guekht, AB; Gulyaeva, NV; Ivanova-Dyatlova, AY; Keren, O; Sarne, Y, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 10 (83.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jin, Y | 1 |
| Cai, S | 1 |
| Jiang, Y | 1 |
| Zhong, K | 1 |
| Wen, C | 1 |
| Ruan, Y | 1 |
| Chew, LA | 1 |
| Khanna, R | 1 |
| Xu, Z | 1 |
| Yu, J | 1 |
| Jin, M | 1 |
| He, Q | 1 |
| Zhang, S | 1 |
| Cui, Y | 1 |
| Han, L | 1 |
| Liu, K | 1 |
| Niknazar, M | 1 |
| Mousavi, SR | 1 |
| Motaghi, S | 1 |
| Dehghani, A | 1 |
| Vosoughi Vahdat, B | 1 |
| Shamsollahi, MB | 1 |
| Sayyah, M | 1 |
| Noorbakhsh, SM | 1 |
| Ben, J | 1 |
| Marques Gonçalves, F | 1 |
| Alexandre Oliveira, P | 1 |
| Vieira Peres, T | 1 |
| Hohl, A | 1 |
| Bainy Leal, R | 1 |
| Abrão Cavalheiro, E | 1 |
| Daniel Schroder Prediger, R | 1 |
| Walz, R | 1 |
| Buenafe, OE | 1 |
| Orellana-Paucar, A | 1 |
| Maes, J | 1 |
| Huang, H | 1 |
| Ying, X | 1 |
| De Borggraeve, W | 1 |
| Crawford, AD | 1 |
| Luyten, W | 1 |
| Esguerra, CV | 1 |
| de Witte, P | 1 |
| Kouis, P | 1 |
| Mikroulis, A | 1 |
| Psarropoulou, C | 1 |
| Lusardi, TA | 1 |
| Akula, KK | 1 |
| Coffman, SQ | 1 |
| Ruskin, DN | 1 |
| Masino, SA | 1 |
| Boison, D | 1 |
| Bascuñana, P | 1 |
| Javela, J | 1 |
| Delgado, M | 1 |
| Fernández de la Rosa, R | 1 |
| Shiha, AA | 1 |
| García-García, L | 1 |
| Pozo, MÁ | 1 |
| Tian, FF | 1 |
| Zeng, C | 1 |
| Ma, YF | 1 |
| Guo, TH | 1 |
| Chen, JM | 1 |
| Chen, Y | 1 |
| Cai, XF | 1 |
| Li, FR | 1 |
| Wang, XH | 1 |
| Huang, WJ | 1 |
| Wang, YZ | 1 |
| Aniol, VA | 1 |
| Ivanova-Dyatlova, AY | 1 |
| Keren, O | 1 |
| Guekht, AB | 1 |
| Sarne, Y | 1 |
| Gulyaeva, NV | 1 |
| Wong, M | 1 |
| Wozniak, DF | 1 |
| Yamada, KA | 1 |
| Kharatishvili, I | 1 |
| Immonen, R | 1 |
| Gröhn, O | 1 |
| Pitkänen, A | 1 |
12 other studies available for pentylenetetrazole and Disease Exacerbation
| Article | Year |
|---|---|
Tetramethylpyrazine Reduces Epileptogenesis Progression in Electrical Kindling Models by Modulating Hippocampal Excitatory Neurotransmission.
Topics: Animals; Anticonvulsants; Anxiety; CA1 Region, Hippocampal; Calcium Channel Blockers; Calcium Channe | 2019 |
Gastrodin Suppresses Pentylenetetrazole-Induced Seizures Progression by Modulating Oxidative Stress in Zebrafish.
Topics: Animals; Benzyl Alcohols; Convulsants; Disease Progression; Dose-Response Relationship, Drug; Glucos | 2018 |
A unified approach for detection of induced epileptic seizures in rats using ECoG signals.
Topics: Algorithms; Animals; Brain; Convulsants; Databases, Factual; Disease Models, Animal; Disease Progres | 2013 |
Brain MAPKs levels are differentially associated with seizures threshold and severity progression in pentylenetetrazole-kindled mice.
Topics: Animals; Brain; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protei | 2013 |
Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models.
Topics: Abietanes; Alzheimer Disease; Animals; Anticonvulsants; Brain Ischemia; Disease Models, Animal; Dise | 2013 |
A single episode of juvenile status epilepticus reduces the threshold to adult seizures in a stimulus-specific way.
Topics: Animals; Animals, Newborn; Convulsants; Disease Models, Animal; Disease Progression; Female; Male; M | 2014 |
Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats.
Topics: Adenosine; Animals; Anticonvulsants; Diet, Ketogenic; Disease Models, Animal; Disease Progression; D | 2015 |
[(18)F]FDG PET Neuroimaging Predicts Pentylenetetrazole (PTZ) Kindling Outcome in Rats.
Topics: Animals; Disease Progression; Fluorodeoxyglucose F18; Kindling, Neurologic; Magnetic Resonance Imagi | 2016 |
Potential roles of Cdk5/p35 and tau protein in hippocampal mossy fiber sprouting in the PTZ kindling model.
Topics: Animals; Cyclin-Dependent Kinase 5; Disease Progression; Epilepsy, Temporal Lobe; Hippocampus; Immun | 2010 |
A single pentylenetetrazole-induced clonic-tonic seizure episode is accompanied by a slowly developing cognitive decline in rats.
Topics: Animals; Cell Proliferation; Cognition Disorders; Disease Progression; Hippocampus; Male; Maze Learn | 2013 |
An animal model of generalized nonconvulsive status epilepticus: immediate characteristics and long-term effects.
Topics: Age Factors; Animals; Behavior, Animal; Brain; Cognition; Convulsants; Disease Models, Animal; Disea | 2003 |
Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesis.
Topics: Animals; Brain Injuries; Cerebral Cortex; Convulsants; Diffusion Magnetic Resonance Imaging; Disease | 2007 |