Page last updated: 2024-11-08

pentylenetetrazole and Diathesis

pentylenetetrazole has been researched along with Diathesis in 80 studies

Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.

Research Excerpts

ExcerptRelevanceReference
" In this study we assessed the susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice with genetically altered uric acid levels by targeting urate oxidase, which is the enzyme responsible for uric acid breakdown."7.83Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice. ( Boon, P; Carrette, E; Delbeke, J; Glorieux, G; Larsen, LE; Portelli, J; Raedt, R; Sprengers, M; Thyrion, L; Van Lysebettens, W; Vonck, K, 2016)
" We showed previously that hypoxia-induced seizures in a neonatal rat model induce rapid phosphorylation of serine-831 (S831) and Serine 845 (S845) sites of the AMPA receptor GluR1 subunit and later neuronal hyperexcitability and epilepsy, suggesting that seizure-induced posttranslational modifications may represent a novel therapeutic target."7.78Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures. ( Fitzgerald, EF; Huganir, RL; Hunganir, RL; Jensen, FE; Klein, PM; Rakhade, SN; Sun, H; Zhou, C, 2012)
" In the present study, we induced lithium and pilocarpine status epilepticus (SE) in 10-day-old (P10) rats."7.71Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures. ( Dubé, C; Koning, E; Nehlig, A, 2002)
"5 g/l in drinking water) on bicuculline- and pentylenetetrazol (PTZ)-induced seizures and c-fos expression were studied in mice."7.69Long-term treatment with some methylxanthines decreases the susceptibility to bicuculline- and pentylenetetrazol-induced seizures in mice. Relationship to c-fos expression and receptor binding. ( Fredholm, BB; Georgiev, V; Johansson, B; Kuosmanen, T, 1996)
"Here, we hypothesized severe preeclampsia is a state of increased seizure susceptibility due to blood-brain barrier (BBB) disruption and neuroinflammation that lowers seizure threshold."5.40Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia. ( Chan, SL; Cipolla, MJ; Johnson, AC; LaMarca, B; Moseley, J; Nagle, KJ; Tremble, SM, 2014)
"Occurrence of seizures following long-term oral administration of caffeine (0."5.35Evidence for the involvement of the adenosine A(2A) receptor in the lowered susceptibility to pentylenetetrazol-induced seizures produced in mice by long-term treatment with caffeine. ( Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM, 2008)
"Three flurothyl convulsions decreased the afterdischarge threshold of the amygdala and enhanced the rate of development of electrical kindling without affecting the intensity of postictal refractoriness."5.27Unidirectional interaction between flurothyl seizures and amygdala kindling. ( Albala, BJ; Moshé, SL; Okada, R; Ono, K, 1985)
" 24h later, animals were subjected to seizures by using either maximal electro shock or pentylenetetrazole."3.85Increase in seizure susceptibility in sepsis like condition explained by spiking cytokines and altered adhesion molecules level with impaired blood brain barrier integrity in experimental model of rats treated with lipopolysaccharides. ( Chakrabarti, A; Medhi, B; Modi, M; Saikia, UN; Sewal, RK, 2017)
" In this study we assessed the susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice with genetically altered uric acid levels by targeting urate oxidase, which is the enzyme responsible for uric acid breakdown."3.83Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice. ( Boon, P; Carrette, E; Delbeke, J; Glorieux, G; Larsen, LE; Portelli, J; Raedt, R; Sprengers, M; Thyrion, L; Van Lysebettens, W; Vonck, K, 2016)
" Secondly, we determined seizure threshold for H1 and H3 receptors agonists and antagonists in mouse model of pentylenetetrazole (PTZ)-induced clonic seizures."3.81Morphine modulates the effects of histamine H1 and H3 receptors on seizure susceptibility in pentylenetetrazole-induced seizure model of mice. ( Alijanpour, S; Amini-Khoei, H; Amiri, S; Dehpour, AR; Gooshe, M; Haj-Mirzaian, A; Hassanipour, M; Mehr, SE; Rahimi-Balaei, M; Shirzadian, A, 2015)
" We showed previously that hypoxia-induced seizures in a neonatal rat model induce rapid phosphorylation of serine-831 (S831) and Serine 845 (S845) sites of the AMPA receptor GluR1 subunit and later neuronal hyperexcitability and epilepsy, suggesting that seizure-induced posttranslational modifications may represent a novel therapeutic target."3.78Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures. ( Fitzgerald, EF; Huganir, RL; Hunganir, RL; Jensen, FE; Klein, PM; Rakhade, SN; Sun, H; Zhou, C, 2012)
" Three tests were used: pentylenetetrazole (PTZ)-induced seizures, isolation-induced ultrasonic vocalizations, and motor performance."3.77Rebound increase in seizure susceptibility but not isolation-induced calls after single administration of clonazepam and Ro 19-8022 in infant rats. ( Kubová, H; Mareš, P; Mikulecká, A, 2011)
"Our findings suggest that the induction of acute seizures with PTZ, but not with MES, in animals pretreated with pilocarpine (regardless of SE induction) might constitute an effective and valuable method to screen AEDs and to study mechanisms involved in pharmacoresistant temporal lobe epilepsy (TLE)."3.75Assessment of seizure susceptibility in pilocarpine epileptic and nonepileptic Wistar rats and of seizure reinduction with pentylenetetrazole and electroshock models. ( Albuquerque, C; Blanco, MM; Cavarsan, CF; dos Santos, JG; Hummel, M; Kohek, SR; Mello, LE; Perez-Mendes, P, 2009)
"In WT mice, morphine dose-dependently decreased the thresholds of both myoclonic jerks and clonus convulsion."3.74[Involvement of endogenous histamine in modulatory effect of morphine on seizure susceptibility in mice]. ( Chen, Z; Jin, CL; Wu, DC; Zhu, YY; Zhu-Ge, ZB, 2007)
" The threshold to generalized clonic seizures induced by timed intravenous infusion of pentylenetetrazole (PTZ) was used as an index of seizure propensity."3.74Seizure susceptibility alteration following reversible cholestasis in mice: Modulation by opioids and nitric oxide. ( Dehpour, AR; Doratotaj, B; Gholipour, T; Honar, H; Jannati, A; Nik, HH; Noorian, AR; Riazi, K; Shariftabrizi, A, 2008)
"The threshold for the clonic seizures (CST) induced by acute intravenous administration of gamma-aminobutyric acid (GABA)-antagonist pentylenetetrazole (PTZ) was assessed in male and female mice."3.72Sex and estrus cycle differences in the modulatory effects of morphine on seizure susceptibility in mice. ( Dehghani, M; Dehpour, AR; Gaskari, SA; Homayoun, H; Honar, H; Rashidi, N; Riazi, K; Sadeghipour, H, 2004)
" In the present study, we induced lithium and pilocarpine status epilepticus (SE) in 10-day-old (P10) rats."3.71Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures. ( Dubé, C; Koning, E; Nehlig, A, 2002)
"The involvement of endogenous opioids and nitric oxide (NO) in the anticonvulsant effects of stress against pentylenetetrazole (PTZ)- or electroconvulsive shock-induced seizures was assessed in mice."3.71The involvement of endogenous opioids and nitricoxidergic pathway in the anticonvulsant effects of foot-shock stress in mice. ( Dehpour, AR; Homayoun, H; Khavandgar, S, 2002)
"Perimenstrual catamenial epilepsy, the increase in seizure frequency that some women with epilepsy experience near the time of menstruation, may in part be related to withdrawal of the progesterone metabolite allopregnanolone, an endogenous anticonvulsant neurosteroid that is a potent positive allosteric gamma-aminobutyric acidA (GABA(A)) receptor modulator."3.71Neurosteroid withdrawal model of perimenstrual catamenial epilepsy. ( Kim, HY; Reddy, DS; Rogawski, MA, 2001)
" Finally, a delayed development of pentylenetetrazole-induced seizures (creating a high-energy demand) was observed in B-CK-/- mice."3.71Creatine kinase B-driven energy transfer in the brain is important for habituation and spatial learning behaviour, mossy fibre field size and determination of seizure susceptibility. ( Cools, AR; Fransen, J; Heerschap, A; In 't Zandt, HJ; Jost, CR; Oerlemans, F; Streijger, F; Van Der Zee, CE; Verheij, M; Wieringa, B, 2002)
"5 g/l in drinking water) on bicuculline- and pentylenetetrazol (PTZ)-induced seizures and c-fos expression were studied in mice."3.69Long-term treatment with some methylxanthines decreases the susceptibility to bicuculline- and pentylenetetrazol-induced seizures in mice. Relationship to c-fos expression and receptor binding. ( Fredholm, BB; Georgiev, V; Johansson, B; Kuosmanen, T, 1996)
"We measured the release of neuropeptide Y (NPY) from hippocampal slices of rats at various times after limbic seizures induced by a subcutaneous injection of 12 mg/kg kainic acid (KA)."3.69Enhanced neuropeptide Y release in the hippocampus is associated with chronic seizure susceptibility in kainic acid treated rats. ( Civenni, G; Messali, S; Monno, A; Rizzi, M; Samanin, R; Vezzani, A, 1994)
" In flurothyl-induced seizures, CA deficient mice displayed longer latencies to the onset of both clonic and tonic-clonic seizures."3.68Reduced susceptibility to seizures in carbonic anhydrase II deficient mutant mice. ( Cammer, W; Moshé, SL; Velísek, L; Xu, SG, 1993)
"Epilepsy is a chronic brain disease affecting millions of people worldwide."1.62Environmental enrichment alters neurobehavioral development following maternal immune activation in mice offspring with epilepsy. ( Mosaferi, B; Najdi, N; Salari, AA; Zeraati, M, 2021)
"Here, we investigated the seizure susceptibility and the role of NRG1-ErbB4 signaling in PV interneurons in the suppression of epileptic seizures for rats subject to early life hypoxia."1.56Increased Seizure Susceptibility for Rats Subject to Early Life Hypoxia Might Be Associated with Brain Dysfunction of NRG1-ErbB4 Signaling in Parvalbumin Interneurons. ( Ding, W; Fan, F; Fang, Y; Hu, L; Lei, B; Liang, D; Zhang, M, 2020)
"In the pentylenetetrazol (PTZ) seizure-susceptibility test, dKO mice had a shorter latency to the first epileptiform spike (p = 0."1.51Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility. ( Bolkvadze, T; Ekolle Ndode-Ekane, X; Koivisto, H; Kyyriäinen, J; Lipponen, A; Pérez, LO; Pitkänen, A; Tanila, H, 2019)
"Alzheimer's disease is a common age associated neurodegenerative disorder associated with an elevated risk of seizures that may be fundamentally connected to cognitive dysfunction."1.46Seizure susceptibility in the APP/PS1 mouse model of Alzheimer's disease and relationship with amyloid β plaques. ( Nuñez, A; Reyes-Marin, KE, 2017)
"Epilepsy or seizure disorder is among the least understood chronic medical conditions affecting over 65 million people worldwide."1.43Disruption of polycystin-L causes hippocampal and thalamocortical hyperexcitability. ( Basora, N; Contreras, D; Du, Y; Harvey, M; Luo, C; Schreiber, TH; Su, X; Wu, M; Yao, G; Zhou, J, 2016)
"We have reported significantly higher convulsion prevalence in patients treated with cefepime than in those treated with meropenem."1.40Convulsive liability of cefepime and meropenem in normal and corneal kindled mice. ( Araki, H; Suemaru, K; Takechi, K; Tanaka, A; Tanaka, M; Watanabe, S, 2014)
"Here, we hypothesized severe preeclampsia is a state of increased seizure susceptibility due to blood-brain barrier (BBB) disruption and neuroinflammation that lowers seizure threshold."1.40Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia. ( Chan, SL; Cipolla, MJ; Johnson, AC; LaMarca, B; Moseley, J; Nagle, KJ; Tremble, SM, 2014)
"We examined the seizure susceptibility of these mice to determine if the presence (BXD29-Trl4(lps-2J)/J) or absence (C57BL/10J) of p-ACC, in strains with MCD, confers a differential response to chemi-convulsive treatment."1.39Differential seizure response in two models of cortical heterotopia. ( Gabel, LA; Ibanez, N; Manglani, M; Ramos, RL; Roberts, J; Rosen, GD, 2013)
" Thus we aim to evaluate the effect of an increase in Cstb gene dosage on spontaneous epileptic activity and susceptibility to PTZ-induced seizure."1.37Characterization of PTZ-induced seizure susceptibility in a down syndrome mouse model that overexpresses CSTB. ( Bizot, JC; Brault, V; Costet, N; Hérault, Y; Martin, B, 2011)
"There is some evidence that epileptic seizures could be induced or increased by 5-hydroxytryptamine (5-HT) attenuation, while augmentation of serotonin functions within the brain (e."1.36Seizure susceptibility alteration through 5-HT(3) receptor: modulation by nitric oxide. ( Dehpour, AR; Ghaffarpour, M; Ghasemi, M; Gholipour, T; Riazi, K, 2010)
" However, in both groups chronic administration of melatonin (20mg/kg) reversed the effect of LD cycle alteration on CST."1.35Effect of acute and chronic photoperiod modulation on pentylenetetrazole-induced clonic seizure threshold in mice. ( Dehpour, AR; Ghahremani, MH; Riazi, K; Tahsili-Fahadan, P; Yahyavi-Firouz-Abadi, N, 2008)
"Occurrence of seizures following long-term oral administration of caffeine (0."1.35Evidence for the involvement of the adenosine A(2A) receptor in the lowered susceptibility to pentylenetetrazol-induced seizures produced in mice by long-term treatment with caffeine. ( Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM, 2008)
"Potentiation of convulsions by BSO treatment was recovered by supplying GSH (10 nmol, i."1.31The possible role of endogenous glutathione as an anticonvulsant in mice. ( Abe, K; Nakanishi, K; Saito, H, 2000)
"Susceptibility to PTZ-induced convulsive seizures was significantly higher in -/- versus +/+ mice."1.31Behavior and physiology of mice lacking the GABAA-receptor delta subunit. ( Banerjee, PK; Homanics, GE; Li, Z; Mihalek, RM; Olsen, RW; Spigelman, I, 2002)
"Stress affects seizure susceptibility in animals and humans, but the underlying mechanisms are obscure."1.31Stress-induced deoxycorticosterone-derived neurosteroids modulate GABA(A) receptor function and seizure susceptibility. ( Reddy, DS; Rogawski, MA, 2002)
"Infantile spasms are generalized convulsive seizures seen in the first year of life."1.31The effects of ACTH and adrenocorticosteroids on seizure susceptibility in 15-day-old male rats. ( Burnham, WM; Edwards, HE; Vimal, S, 2002)
" We demonstrate that jerky has a dosage-sensitive function (haploinsufficiency) in brain and that this sensitivity to reduced jerky dosage could explain the occurrence of seizures in hemizygotes."1.30Sensitivity to jerky gene dosage underlies epileptic seizures in mice. ( Donovan, GP; Gal, J; Gudas, LJ; Harden, C; Ho, L; Sibille, E; Toth, M; Trifiletti, R, 1997)
"Results indicate that seizure threshold was significantly elevated with increasing ketogenic ratios (i."1.30Path analysis shows that increasing ketogenic ratio, but not beta-hydroxybutyrate, elevates seizure threshold in the Rat. ( Bough, KJ; Chen, RS; Eagles, DA, 1999)
"Pregnenolone sulfate (PS) is an endogenous neurosteroid known to antagonize GABA(A) receptor-mediated inhibitory responses and potentiate NMDA receptor-mediated excitatory responses in vitro."1.30Convulsant actions of the neurosteroid pregnenolone sulfate in mice. ( Juhng, KN; Kirkby, RD; Kokate, TG; Llamas, J; Rogawski, MA; Yamaguchi, S, 1999)
"glucocorticoids on convulsions."1.29Type I corticosteroid receptors modulate PTZ-induced convulsions of withdrawal seizure prone mice. ( Crabbe, JC; Keith, LD; Roberts, AJ, 1993)
"Convulsions were induced by heat or pentylenetetrazol on days 1, 10 or 21."1.29The effects of a single neonatally induced convulsion on spatial navigation, locomotor activity and convulsion susceptibility in the adult rat. ( Boon, F; Cain, DP; Kornelsen, RA; Leung, LS, 1996)
"Increased susceptibility to seizures in the deficient animals was observed as increased severity of the seizures, decreased threshold for the dose of the chemostimulant and time to seizure, or a combination thereof."1.29Indispensable amino acid deficiency and increased seizure susceptibility in rats. ( Barrett, JA; Dixon, KD; Gietzen, DW; Jones, AC; Truong, BG; Washburn, DS, 1996)
"Other convulsion types, e."1.29Mineralocorticoid receptors mediate the enhancing effects of corticosterone on convulsion susceptibility in mice. ( Keith, LD; Roberts, AJ, 1994)
"In addition, ED and latency to convulsion were measured in WSP and WSR mice at 5 different concentrations of PTZ."1.28Neural sensitivity to pentylenetetrazol convulsions in inbred and selectively bred mice. ( Crabbe, JC; Cross, SJ; Kosobud, AE, 1992)
"Convulsions were caused by intraabdominal injections of corazol."1.28[Correlations of convulsive and hypoxic resistance in rats at different stages of ontogenesis]. ( Agadzhanian, NA; Starykh, EV; Torshin, VI, 1991)
"Three flurothyl convulsions decreased the afterdischarge threshold of the amygdala and enhanced the rate of development of electrical kindling without affecting the intensity of postictal refractoriness."1.27Unidirectional interaction between flurothyl seizures and amygdala kindling. ( Albala, BJ; Moshé, SL; Okada, R; Ono, K, 1985)
"Convulsions were induced in young rats (1-21 days) with pentylenetetrazol or hyperthermia."1.27A single neonatal pentylenetetrazol or hyperthermia convulsion increases kindling susceptibility in the adult rat. ( Cain, DP; Gilbert, ME, 1985)

Research

Studies (80)

TimeframeStudies, this research(%)All Research%
pre-199011 (13.75)18.7374
1990's17 (21.25)18.2507
2000's23 (28.75)29.6817
2010's24 (30.00)24.3611
2020's5 (6.25)2.80

Authors

AuthorsStudies
Villalpando-Vargas, F1
Medina-Ceja, L1
Santerre, A1
Enciso-Madero, EA1
Nesci, V1
Russo, E1
Arcidiacono, B1
Citraro, R1
Tallarico, M1
Constanti, A1
Brunetti, A1
De Sarro, G1
Leo, A1
Liang, D1
Fan, F1
Ding, W1
Fang, Y1
Hu, L1
Lei, B1
Zhang, M1
Sinha, P1
Verma, B1
Ganesh, S1
Zeraati, M1
Najdi, N1
Mosaferi, B1
Salari, AA1
Díaz-Alonso, J1
de Salas-Quiroga, A1
Paraíso-Luna, J1
García-Rincón, D1
Garcez, PP1
Parsons, M1
Andradas, C1
Sánchez, C1
Guillemot, F1
Guzmán, M1
Galve-Roperh, I1
Sewal, RK1
Modi, M1
Saikia, UN1
Chakrabarti, A1
Medhi, B1
Reyes-Marin, KE1
Nuñez, A1
Kyyriäinen, J1
Bolkvadze, T1
Koivisto, H1
Lipponen, A1
Pérez, LO1
Ekolle Ndode-Ekane, X1
Tanila, H1
Pitkänen, A2
Chmielewska, N1
Maciejak, P1
Turzyńska, D1
Sobolewska, A1
Wisłowska-Stanek, A1
Kołosowska, K1
Płaźnik, A1
Szyndler, J1
Aksoy, D1
Solmaz, V1
Taşkıran, D1
Erbaş, O1
Tanaka, A2
Takechi, K1
Watanabe, S1
Tanaka, M1
Suemaru, K1
Araki, H1
Dai, YJ1
Xu, ZH1
Feng, B1
Xu, CL1
Zhao, HW1
Wu, DC2
Hu, WW1
Chen, Z3
Johnson, AC1
Tremble, SM1
Chan, SL1
Moseley, J1
LaMarca, B1
Nagle, KJ1
Cipolla, MJ1
Amini-Khoei, H1
Rahimi-Balaei, M1
Amiri, S1
Haj-Mirzaian, A1
Hassanipour, M1
Shirzadian, A1
Gooshe, M1
Alijanpour, S1
Mehr, SE1
Dehpour, AR6
Yao, G1
Luo, C1
Harvey, M1
Wu, M1
Schreiber, TH1
Du, Y1
Basora, N1
Su, X1
Contreras, D1
Zhou, J1
Thyrion, L1
Portelli, J1
Raedt, R1
Glorieux, G1
Larsen, LE1
Sprengers, M1
Van Lysebettens, W1
Carrette, E1
Delbeke, J1
Vonck, K1
Boon, P1
Grauncke, AC1
Souza, TL1
Ribeiro, LR1
Brant, F1
Machado, FS1
Oliveira, MS1
Shen, Y1
Qin, H1
Chen, J1
Mou, L1
He, Y1
Yan, Y1
Zhou, H1
Lv, Y1
Wang, J1
Zhou, YD1
Qin, R1
Cao, S1
Lyu, T1
Qi, C1
Zhang, W1
Wang, Y1
Tahsili-Fahadan, P1
Yahyavi-Firouz-Abadi, N1
Riazi, K4
Ghahremani, MH1
Blanco, MM1
dos Santos, JG1
Perez-Mendes, P1
Kohek, SR1
Cavarsan, CF1
Hummel, M1
Albuquerque, C1
Mello, LE1
Bae, MH1
Bissonette, GB1
Mars, WM1
Michalopoulos, GK1
Achim, CL1
Depireux, DA1
Powell, EM1
Gholipour, T2
Ghasemi, M1
Ghaffarpour, M1
Uzüm, G1
Akgün-Dar, K1
Aksu, U1
Mikulecká, A1
Mareš, P2
Kubová, H2
Brault, V1
Martin, B1
Costet, N1
Bizot, JC1
Hérault, Y1
Harai, T1
Inoue, R1
Fujita, Y1
Horio, M1
Hashimoto, K1
Hongou, K1
Miyawaki, T1
Mori, H1
Buga, AM1
Vintilescu, R1
Balseanu, AT1
Pop, OT1
Streba, C1
Toescu, E1
Popa-Wagner, A2
Gabel, LA1
Manglani, M1
Ibanez, N1
Roberts, J1
Ramos, RL1
Rosen, GD1
Rakhade, SN1
Fitzgerald, EF1
Klein, PM1
Zhou, C1
Sun, H1
Huganir, RL1
Hunganir, RL1
Jensen, FE1
Spigelman, I1
Li, Z1
Banerjee, PK1
Mihalek, RM1
Homanics, GE1
Olsen, RW1
Nehlig, A1
Dubé, C1
Koning, E1
Schmoll, H1
Badan, I1
Grecksch, G1
Walker, L1
Kessler, C1
SVORAD, D2
ONUMA, T1
DOLINA, SA1
SWINYARD, EA1
SCHIFFMAN, DO1
GOODMAN, LS1
Wu, HM1
Liang, YC1
Chen, SH2
Huang, CC1
Tsai, JJ1
Hsieh, CL1
Hsu, KS1
Honar, H2
Homayoun, H2
Rashidi, N1
Dehghani, M1
Sadeghipour, H1
Gaskari, SA1
Chen, WF1
Chang, H1
Huang, LT1
Lai, MC1
Yang, CH1
Wan, TH1
Yang, SN1
Locke, CJ1
Williams, SN1
Schwarz, EM1
Caldwell, GA1
Caldwell, KA1
Tchekalarova, J2
Zhu-Ge, ZB1
Zhu, YY1
Jin, CL1
Kharatishvili, I1
Immonen, R1
Gröhn, O1
Noorian, AR1
Jannati, A1
Doratotaj, B1
Nik, HH1
Shariftabrizi, A1
El Yacoubi, M1
Ledent, C1
Parmentier, M1
Costentin, J1
Vaugeois, JM1
Holmes, GL2
Albala, BJ2
Moshé, SL3
McCaughran, JA1
Manetto, C1
Vezzani, A1
Civenni, G1
Rizzi, M1
Monno, A1
Messali, S1
Samanin, R1
Roberts, AJ2
Keith, LD2
Crabbe, JC2
Velísek, L1
Xu, SG1
Cammer, W1
Kornelsen, RA1
Boon, F1
Leung, LS1
Cain, DP2
Gietzen, DW1
Dixon, KD1
Truong, BG1
Jones, AC1
Barrett, JA1
Washburn, DS1
Sircar, R1
Johansson, B1
Georgiev, V2
Kuosmanen, T1
Fredholm, BB1
Madeja, M1
Musshoff, U1
Speckmann, EJ1
Donovan, GP1
Harden, C1
Gal, J1
Ho, L1
Sibille, E1
Trifiletti, R1
Gudas, LJ1
Toth, M1
Snyder-Keller, A1
Keller, RW1
Kokate, TG1
Juhng, KN1
Kirkby, RD1
Llamas, J1
Yamaguchi, S1
Rogawski, MA3
Bough, KJ1
Chen, RS1
Eagles, DA1
Abe, K1
Nakanishi, K1
Saito, H1
Silveira, DC1
Schachter, SC1
Geula, C1
Schomer, DL1
Reddy, DS2
Kim, HY1
Golarai, G1
Greenwood, AC1
Feeney, DM1
Connor, JA1
Kambourova, T1
Edwards, HE1
Vimal, S1
Burnham, WM1
Khavandgar, S1
Jost, CR1
Van Der Zee, CE1
In 't Zandt, HJ1
Oerlemans, F1
Verheij, M1
Streijger, F1
Fransen, J1
Heerschap, A1
Cools, AR1
Wieringa, B1
Chiba, S1
Muneoka, Y1
Sato, Y1
Miyagishi, T1
Kosobud, AE1
Cross, SJ1
Giorgi, O1
Orlandi, M1
Geic, M1
Corda, MG1
Agadzhanian, NA1
Torshin, VI1
Starykh, EV1
Schmidt, J1
Okada, R1
Ono, K1
Gilbert, ME1
Hunt, WA1

Other Studies

80 other studies available for pentylenetetrazole and Diathesis

ArticleYear
The anticonvulsant effect of sparteine on pentylenetetrazole-induced seizures in rats: a behavioral, electroencephalographic, morphological and molecular study.
    Journal of molecular histology, 2020, Volume: 51, Issue:5

    Topics: Animals; Anticonvulsants; Behavior, Animal; Biomarkers; Brain; Disease Management; Disease Models, A

2020
Metabolic Alterations Predispose to Seizure Development in High-Fat Diet-Treated Mice: the Role of Metformin.
    Molecular neurobiology, 2020, Volume: 57, Issue:11

    Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Blood Glucose; Body Composition; Depression;

2020
Increased Seizure Susceptibility for Rats Subject to Early Life Hypoxia Might Be Associated with Brain Dysfunction of NRG1-ErbB4 Signaling in Parvalbumin Interneurons.
    Molecular neurobiology, 2020, Volume: 57, Issue:12

    Topics: Animals; Animals, Newborn; Brain; Cell Count; Disease Susceptibility; Female; Gene Expression Regula

2020
Trehalose Ameliorates Seizure Susceptibility in Lafora Disease Mouse Models by Suppressing Neuroinflammation and Endoplasmic Reticulum Stress.
    Molecular neurobiology, 2021, Volume: 58, Issue:3

    Topics: Animals; Autophagy; Brain; Calcium-Binding Proteins; Disease Models, Animal; Disease Susceptibility;

2021
Environmental enrichment alters neurobehavioral development following maternal immune activation in mice offspring with epilepsy.
    Behavioural brain research, 2021, 02-05, Volume: 399

    Topics: Animals; Anxiety; Behavior, Animal; Cognitive Dysfunction; Convulsants; Disease Models, Animal; Dise

2021
Loss of Cannabinoid CB1 Receptors Induces Cortical Migration Malformations and Increases Seizure Susceptibility.
    Cerebral cortex (New York, N.Y. : 1991), 2017, 11-01, Volume: 27, Issue:11

    Topics: Animals; Cell Movement; Cerebral Cortex; Disease Models, Animal; Disease Susceptibility; Electropora

2017
Increase in seizure susceptibility in sepsis like condition explained by spiking cytokines and altered adhesion molecules level with impaired blood brain barrier integrity in experimental model of rats treated with lipopolysaccharides.
    Epilepsy research, 2017, Volume: 135

    Topics: Animals; Blood-Brain Barrier; Capillary Permeability; Cytokines; Disease Models, Animal; Disease Sus

2017
Seizure susceptibility in the APP/PS1 mouse model of Alzheimer's disease and relationship with amyloid β plaques.
    Brain research, 2017, Dec-15, Volume: 1677

    Topics: Alzheimer Disease; Animals; Benzylamines; Cerebral Cortex; Disease Models, Animal; Disease Susceptib

2017
Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility.
    Epilepsy research, 2019, Volume: 151

    Topics: Animals; Anxiety; Avoidance Learning; Brain Waves; Convulsants; Disease Models, Animal; Disease Susc

2019
The role of UCH-L1, MMP-9, and GFAP as peripheral markers of different susceptibility to seizure development in a preclinical model of epilepsy.
    Journal of neuroimmunology, 2019, 07-15, Volume: 332

    Topics: Animals; Biomarkers; Brain Chemistry; Convulsants; Disease Susceptibility; Glial Fibrillary Acidic P

2019
The association between seizure predisposition and inflammation in a rat model of fatty liver disease.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2014, Volume: 35, Issue:9

    Topics: Animals; Brain; Convulsants; Disease Susceptibility; Electroencephalography; Fatty Liver; Fructose;

2014
Convulsive liability of cefepime and meropenem in normal and corneal kindled mice.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:8

    Topics: Animals; Anti-Bacterial Agents; Cefepime; Cephalosporins; Convulsants; Disease Susceptibility; Drug

2014
Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures.
    Neuroscience bulletin, 2014, Volume: 30, Issue:6

    Topics: Animals; Convulsants; Disease Models, Animal; Disease Susceptibility; Electroshock; Female; Fever; M

2014
Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia.
    PloS one, 2014, Volume: 9, Issue:11

    Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Convulsants; Diet, High-Fat; Disease Models, Anima

2014
Morphine modulates the effects of histamine H1 and H3 receptors on seizure susceptibility in pentylenetetrazole-induced seizure model of mice.
    European journal of pharmacology, 2015, Dec-15, Volume: 769

    Topics: Animals; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Histamine

2015
Disruption of polycystin-L causes hippocampal and thalamocortical hyperexcitability.
    Human molecular genetics, 2016, Feb-01, Volume: 25, Issue:3

    Topics: Animals; Calcium Channels; Cerebral Cortex; Cilia; Cyclic AMP; Cyclic AMP Response Element-Binding P

2016
Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice.
    Epilepsia, 2016, Volume: 57, Issue:7

    Topics: Animals; Brain; Convulsants; Disease Models, Animal; Disease Susceptibility; Mice; Mice, Inbred C57B

2016
Increased susceptibility to pentylenetetrazol following survival of cerebral malaria in mice.
    Epilepsia, 2016, Volume: 57, Issue:7

    Topics: Animals; Body Weight; Convulsants; Disease Models, Animal; Disease Susceptibility; Electroencephalog

2016
Postnatal activation of TLR4 in astrocytes promotes excitatory synaptogenesis in hippocampal neurons.
    The Journal of cell biology, 2016, Dec-05, Volume: 215, Issue:5

    Topics: Animals; Animals, Newborn; Astrocytes; Coculture Techniques; Dendrites; Disease Susceptibility; Enzy

2016
CDYL Deficiency Disrupts Neuronal Migration and Increases Susceptibility to Epilepsy.
    Cell reports, 2017, 01-10, Volume: 18, Issue:2

    Topics: Actin Cytoskeleton; Actins; Animals; Brain; Cell Movement; Cell Polarity; Chromatin; Co-Repressor Pr

2017
Effect of acute and chronic photoperiod modulation on pentylenetetrazole-induced clonic seizure threshold in mice.
    Epilepsy research, 2008, Volume: 82, Issue:1

    Topics: Animals; Circadian Rhythm; Disease Susceptibility; Male; Melatonin; Mice; Pentylenetetrazole; Photop

2008
Assessment of seizure susceptibility in pilocarpine epileptic and nonepileptic Wistar rats and of seizure reinduction with pentylenetetrazole and electroshock models.
    Epilepsia, 2009, Volume: 50, Issue:4

    Topics: Analysis of Variance; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Disease Suscept

2009
Hepatocyte growth factor (HGF) modulates GABAergic inhibition and seizure susceptibility.
    Experimental neurology, 2010, Volume: 221, Issue:1

    Topics: Action Potentials; Analysis of Variance; Animals; Animals, Genetically Modified; Animals, Newborn; A

2010
Seizure susceptibility alteration through 5-HT(3) receptor: modulation by nitric oxide.
    Seizure, 2010, Volume: 19, Issue:1

    Topics: Animals; Anticonvulsants; Arginine; Disease Models, Animal; Disease Susceptibility; Dose-Response Re

2010
The effects of atorvastatin on memory deficit and seizure susceptibility in pentylentetrazole-kindled rats.
    Epilepsy & behavior : E&B, 2010, Volume: 19, Issue:3

    Topics: Analysis of Variance; Animals; Anticholesteremic Agents; Atorvastatin; Avoidance Learning; Disease S

2010
Rebound increase in seizure susceptibility but not isolation-induced calls after single administration of clonazepam and Ro 19-8022 in infant rats.
    Epilepsy & behavior : E&B, 2011, Volume: 20, Issue:1

    Topics: Analysis of Variance; Animals; Animals, Newborn; Clonazepam; Disease Susceptibility; GABA Modulators

2011
Characterization of PTZ-induced seizure susceptibility in a down syndrome mouse model that overexpresses CSTB.
    PloS one, 2011, Volume: 6, Issue:11

    Topics: Animals; Atrophy; Brain; Cystatin B; Disease Models, Animal; Disease Susceptibility; Down Syndrome;

2011
Decreased susceptibility to seizures induced by pentylenetetrazole in serine racemase knockout mice.
    Epilepsy research, 2012, Volume: 102, Issue:3

    Topics: Amino Acids; Analysis of Variance; Animals; Brain; Chromatography, High Pressure Liquid; Convulsants

2012
Repeated PTZ treatment at 25-day intervals leads to a highly efficient accumulation of doublecortin in the dorsal hippocampus of rats.
    PloS one, 2012, Volume: 7, Issue:6

    Topics: Animals; Biomarkers; Bromodeoxyuridine; Cell Count; Cell Lineage; Disease Susceptibility; Dose-Respo

2012
Differential seizure response in two models of cortical heterotopia.
    Brain research, 2013, Feb-04, Volume: 1494

    Topics: Agenesis of Corpus Callosum; Animals; Cerebral Cortex; Choristoma; Convulsants; Disease Models, Anim

2013
Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Dec-05, Volume: 32, Issue:49

    Topics: Animals; Animals, Newborn; Cerebral Cortex; Disease Models, Animal; Disease Susceptibility; Disks La

2012
Behavior and physiology of mice lacking the GABAA-receptor delta subunit.
    Epilepsia, 2002, Volume: 43 Suppl 5

    Topics: Animals; Behavior, Animal; Cell Membrane; Disease Susceptibility; Female; Kinetics; Male; Mice; Mice

2002
Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures.
    Epilepsy research, 2002, Volume: 51, Issue:1-2

    Topics: Aging; Animals; Animals, Newborn; Cerebellar Cortex; Disease Models, Animal; Disease Susceptibility;

2002
Kindling status in sprague-dawley rats induced by pentylenetetrazole: involvement of a critical development period.
    The American journal of pathology, 2003, Volume: 162, Issue:3

    Topics: Animals; Biomarkers; Blotting, Northern; Disease Models, Animal; Disease Susceptibility; Epilepsy; G

2003
[Susceptibility to convulsions in phylogenesis; experimental convulsions in vertebrates produced with cardiazole].
    Ceskoslovenska fysiologie, 1955, Jul-20, Volume: 4, Issue:3

    Topics: Animals; Disease Susceptibility; Pentylenetetrazole; Phylogeny; Seizures; Vertebrates

1955
Paroxysmal susceptibility in the light of phylogenesis; experimental convulsions in vertebrates, elicited by cardiazol.
    Chekhoslovatskaia fiziologiia, 1955, Volume: 4, Issue:3

    Topics: Animals; Disease Susceptibility; Pentylenetetrazole; Phylogeny; Seizures; Vertebrates

1955
Relationships of the predisposition to convulsions with the action potentials of the autonomic nerves and the brain. II. Changes in action potential of the autonomic nerves and the brain under conditions for increasing the predisposition to convulsions.
    The Tohoku journal of experimental medicine, 1957, Feb-25, Volume: 65, Issue:2-3

    Topics: Action Potentials; Autonomic Nervous System; Autonomic Pathways; Brain; Disease Susceptibility; Huma

1957
[ON PHYSIOLOGICAL ANALYSIS OF "PREDISPOSITION TO CONVULSIONS"].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1963, Volume: 63

    Topics: Brain; Camphor; Cerebral Cortex; Disease Susceptibility; Electrophysiological Phenomena; Electrophys

1963
Effect of variations in extracellular sodium concentration on the susceptibility of mice to pentylenetetrazole (metrazol)-induced seizures.
    The Journal of pharmacology and experimental therapeutics, 1955, Volume: 114, Issue:2

    Topics: Animals; Blood; Disease Susceptibility; Mice; Pentylenetetrazole; Seizures; Sodium

1955
Valacyclovir treatment ameliorates the persistently increased pentylenetetrazol-induced seizure susceptibility in mice with herpes simplex virus type 1 infection.
    Experimental neurology, 2004, Volume: 189, Issue:1

    Topics: Acyclovir; Animals; Antiviral Agents; Behavior, Animal; Body Weight; Disease Susceptibility; Dose-Re

2004
Sex and estrus cycle differences in the modulatory effects of morphine on seizure susceptibility in mice.
    Epilepsia, 2004, Volume: 45, Issue:9

    Topics: Animals; Anticonvulsants; Convulsants; Disease Susceptibility; Dose-Response Relationship, Drug; Est

2004
Alterations in long-term seizure susceptibility and the complex of PSD-95 with NMDA receptor from animals previously exposed to perinatal hypoxia.
    Epilepsia, 2006, Volume: 47, Issue:2

    Topics: Animals; Animals, Newborn; Brain; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Disease M

2006
Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans.
    Brain research, 2006, Nov-20, Volume: 1120, Issue:1

    Topics: Animals; Animals, Genetically Modified; Behavior, Animal; Caenorhabditis elegans; Caenorhabditis ele

2006
Effects of postnatal caffeine exposure on seizure susceptibility in developing rats.
    Brain research, 2007, May-30, Volume: 1150

    Topics: Age Factors; Aminophylline; Animals; Animals, Newborn; Behavior, Animal; Bicuculline; Caffeine; Cent

2007
[Involvement of endogenous histamine in modulatory effect of morphine on seizure susceptibility in mice].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2007, Volume: 36, Issue:2

    Topics: Animals; Disease Susceptibility; Dose-Response Relationship, Drug; Histamine; Histidine Decarboxylas

2007
Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesis.
    Brain : a journal of neurology, 2007, Volume: 130, Issue:Pt 12

    Topics: Animals; Brain Injuries; Cerebral Cortex; Convulsants; Diffusion Magnetic Resonance Imaging; Disease

2007
Seizure susceptibility alteration following reversible cholestasis in mice: Modulation by opioids and nitric oxide.
    European journal of pharmacology, 2008, Feb-12, Volume: 580, Issue:3

    Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Bilirubin; Biomarkers; Cholestasis; Corn Oi

2008
Evidence for the involvement of the adenosine A(2A) receptor in the lowered susceptibility to pentylenetetrazol-induced seizures produced in mice by long-term treatment with caffeine.
    Neuropharmacology, 2008, Volume: 55, Issue:1

    Topics: Analysis of Variance; Animals; Caffeine; Disease Models, Animal; Disease Susceptibility; Dose-Respon

2008
Effect of a single brief seizure on subsequent seizure susceptibility in the immature rat.
    Archives of neurology, 1984, Volume: 41, Issue:8

    Topics: Animals; Disease Susceptibility; Electroshock; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy;

1984
Potentiation of hyperthermia-induced convulsions in the developing rat by previous treatment with pentylenetetrazol.
    Experimental neurology, 1983, Volume: 79, Issue:1

    Topics: Animals; Disease Models, Animal; Disease Susceptibility; Male; Pentylenetetrazole; Rats; Rats, Inbre

1983
Enhanced neuropeptide Y release in the hippocampus is associated with chronic seizure susceptibility in kainic acid treated rats.
    Brain research, 1994, Oct-10, Volume: 660, Issue:1

    Topics: Animals; Antibodies; Chronic Disease; Disease Susceptibility; Dose-Response Relationship, Drug; Elec

1994
Mineralocorticoid receptors mediate the enhancing effects of corticosterone on convulsion susceptibility in mice.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 270, Issue:2

    Topics: Animals; Corticosterone; Disease Susceptibility; Kainic Acid; Male; Mice; Mice, Inbred Strains; Pent

1994
Type I corticosteroid receptors modulate PTZ-induced convulsions of withdrawal seizure prone mice.
    Brain research, 1993, Oct-29, Volume: 626, Issue:1-2

    Topics: Aminoglutethimide; Animals; Desoxycorticosterone; Dexamethasone; Disease Susceptibility; Ethanol; Ma

1993
Reduced susceptibility to seizures in carbonic anhydrase II deficient mutant mice.
    Epilepsy research, 1993, Volume: 14, Issue:2

    Topics: Acoustic Stimulation; Animals; Carbonic Anhydrases; Disease Susceptibility; Epilepsy, Tonic-Clonic;

1993
The effects of a single neonatally induced convulsion on spatial navigation, locomotor activity and convulsion susceptibility in the adult rat.
    Brain research, 1996, Jan-08, Volume: 706, Issue:1

    Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Disease Susceptibility; Hot Temperature; Mal

1996
Indispensable amino acid deficiency and increased seizure susceptibility in rats.
    The American journal of physiology, 1996, Volume: 271, Issue:1 Pt 2

    Topics: Amino Acids; Animals; Bicuculline; Differential Threshold; Disease Susceptibility; Drug Administrati

1996
Repeated postnatal phencyclidine administration in female juvenile rat delays onset of puberty but has no effect on pentylenetetrazol-induced seizure-susceptibility.
    Brain research, 1995, Oct-02, Volume: 694, Issue:1-2

    Topics: Animals; Animals, Newborn; Disease Susceptibility; Estrus; Female; Ovulation; Pentylenetetrazole; Ph

1995
Long-term treatment with some methylxanthines decreases the susceptibility to bicuculline- and pentylenetetrazol-induced seizures in mice. Relationship to c-fos expression and receptor binding.
    The European journal of neuroscience, 1996, Volume: 8, Issue:12

    Topics: Animals; Autoradiography; Behavior, Animal; Bicuculline; Brain; Caffeine; Disease Susceptibility; Ma

1996
Diversity of potassium channels contributing to differences in brain area-specific seizure susceptibility: sensitivity of different potassium channels to the epileptogenic agent pentylenetetrazol.
    The European journal of neuroscience, 1997, Volume: 9, Issue:2

    Topics: Animals; Brain Mapping; Cerebellum; Cerebral Cortex; Disease Susceptibility; Epilepsy; Hippocampus;

1997
Sensitivity to jerky gene dosage underlies epileptic seizures in mice.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Jun-15, Volume: 17, Issue:12

    Topics: Aging; Alleles; Amino Acid Sequence; Animals; Brain; Cerebral Cortex; Disease Susceptibility; DNA Pr

1997
Prenatal cocaine exposure increases susceptibility to drug-induced seizures. c-fos induction and brain cocaine levels.
    Annals of the New York Academy of Sciences, 1998, Jun-21, Volume: 846

    Topics: Animals; Brain; Cocaine; Disease Susceptibility; Female; Gene Expression Regulation; Male; Pentylene

1998
Convulsant actions of the neurosteroid pregnenolone sulfate in mice.
    Brain research, 1999, Jun-12, Volume: 831, Issue:1-2

    Topics: Animals; Convulsants; Disease Susceptibility; Drug Synergism; Injections, Intraventricular; Male; Mi

1999
Path analysis shows that increasing ketogenic ratio, but not beta-hydroxybutyrate, elevates seizure threshold in the Rat.
    Developmental neuroscience, 1999, Volume: 21, Issue:3-5

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Body Weight; Convulsants; Diet; Differential Threshold; Disea

1999
The possible role of endogenous glutathione as an anticonvulsant in mice.
    Brain research, 2000, Jan-31, Volume: 854, Issue:1-2

    Topics: Animals; Brain; Buthionine Sulfoximine; Convulsants; Disease Susceptibility; Drug Synergism; Glutath

2000
Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats.
    Brain research, 2000, Sep-29, Volume: 878, Issue:1-2

    Topics: Acetylcholinesterase; Animals; Convulsants; Denervation; Disease Susceptibility; Epilepsy, Generaliz

2000
Neurosteroid withdrawal model of perimenstrual catamenial epilepsy.
    Epilepsia, 2001, Volume: 42, Issue:3

    Topics: 20-alpha-Dihydroprogesterone; Adult; Animals; Behavior, Animal; Disease Models, Animal; Disease Susc

2001
Physiological and structural evidence for hippocampal involvement in persistent seizure susceptibility after traumatic brain injury.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Nov-01, Volume: 21, Issue:21

    Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Injuries; Cell Count; Cell Death; Chronic Disease; Denta

2001
Effects of angiotensin III and angiotensin IV on pentylenetetrazol seizure susceptibility (threshold and kindling): interaction with adenosine A(1) receptors.
    Brain research bulletin, 2001, Sep-15, Volume: 56, Issue:2

    Topics: Adenosine; Angiotensin II; Angiotensin III; Angiotensins; Animals; Brain; Convulsants; Disease Susce

2001
Stress-induced deoxycorticosterone-derived neurosteroids modulate GABA(A) receptor function and seizure susceptibility.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, May-01, Volume: 22, Issue:9

    Topics: 5-alpha Reductase Inhibitors; Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Convu

2002
The effects of ACTH and adrenocorticosteroids on seizure susceptibility in 15-day-old male rats.
    Experimental neurology, 2002, Volume: 175, Issue:1

    Topics: Adrenocorticotropic Hormone; Aldosterone; Animals; Corticosterone; Dehydroepiandrosterone; Desoxycor

2002
The involvement of endogenous opioids and nitricoxidergic pathway in the anticonvulsant effects of foot-shock stress in mice.
    Epilepsy research, 2002, Volume: 49, Issue:2

    Topics: Animals; Convulsants; Differential Threshold; Disease Susceptibility; Electroshock; Endorphins; Foot

2002
Creatine kinase B-driven energy transfer in the brain is important for habituation and spatial learning behaviour, mossy fibre field size and determination of seizure susceptibility.
    The European journal of neuroscience, 2002, Volume: 15, Issue:10

    Topics: Animals; Behavior, Animal; Brain; Convulsants; Creatine Kinase; Creatine Kinase, BB Form; Disease Su

2002
[Seizure susceptibility in aged rats--pentylenetetrazol-induced seizures and amygdaloid kindling seizures].
    No to shinkei = Brain and nerve, 1992, Volume: 44, Issue:6

    Topics: Aging; Amygdala; Animals; Disease Susceptibility; Kindling, Neurologic; Male; Pentylenetetrazole; Ra

1992
Neural sensitivity to pentylenetetrazol convulsions in inbred and selectively bred mice.
    Brain research, 1992, Oct-02, Volume: 592, Issue:1-2

    Topics: Animals; Body Weight; Brain; Disease Susceptibility; Dose-Response Relationship, Drug; Environment;

1992
MK-801 prevents the decrease in 35S-TBPS binding in the rat cerebral cortex induced by pentylenetetrazol kindling.
    Brain research bulletin, 1991, Volume: 27, Issue:6

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Convul

1991
[Correlations of convulsive and hypoxic resistance in rats at different stages of ontogenesis].
    Biulleten' eksperimental'noi biologii i meditsiny, 1991, Volume: 111, Issue:1

    Topics: Age Factors; Animals; Animals, Newborn; Atmosphere Exposure Chambers; Disease Models, Animal; Diseas

1991
Lithium suppresses seizure susceptibility in pentylenetetrazol-kindled rats.
    Biomedica biochimica acta, 1986, Volume: 45, Issue:9

    Topics: Animals; Chlorides; Disease Susceptibility; Female; Kindling, Neurologic; Lithium; Lithium Chloride;

1986
Unidirectional interaction between flurothyl seizures and amygdala kindling.
    Brain research, 1985, Sep-30, Volume: 344, Issue:1

    Topics: Amygdala; Animals; Disease Susceptibility; Electric Stimulation; Flurothyl; Kindling, Neurologic; Ma

1985
A single neonatal pentylenetetrazol or hyperthermia convulsion increases kindling susceptibility in the adult rat.
    Brain research, 1985, Volume: 354, Issue:2

    Topics: Amygdala; Animals; Animals, Newborn; Disease Susceptibility; Hippocampus; Hyperthermia, Induced; Kin

1985
Changes in the neuro-excitability of alcohol-dependent rats undergoing withdrawal as measured by the pentylenetetrazole seizure threshold.
    Neuropharmacology, 1973, Volume: 12, Issue:11

    Topics: Animals; Disease Susceptibility; Ethanol; Humans; Male; Pentylenetetrazole; Proadifen; Rats; Seizure

1973