pentylenetetrazole has been researched along with Delayed Effects, Prenatal Exposure in 16 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "LCM and LEV were both effective against seizures induced by PTZ." | 5.46 | Treatment with lacosamide impedes generalized seizures in a rodent model of cortical dysplasia. ( Alexopoulos, AV; Gonzalez-Martinez, J; Najm, IM; Nemes, AD; O'Dwyer, R; Ying, Z, 2017) |
| "Following cocaine-induced seizures, intense c-fos induction was observed in piriform cortex, amygdala, and hippocampus." | 5.31 | Spatiotemporal analysis of Fos expression associated with cocaine- and PTZ-induced seizures in prenatally cocaine-treated rats. ( Keller, RW; Snyder-Keller, A, 2001) |
| " We have previously reported the presence of SBH in a rodent model of low level hypothyroidism induced by maternal exposure to the goitrogen, propylthiouracil (PTU)." | 3.80 | Subcortical band heterotopia in rat offspring following maternal hypothyroxinaemia: structural and functional characteristics. ( Gilbert, ME; Goodman, JH; McCloskey, DP; Ramos, RL, 2014) |
| "Epilepsy is a chronic brain disease affecting millions of people worldwide." | 1.62 | Environmental enrichment alters neurobehavioral development following maternal immune activation in mice offspring with epilepsy. ( Mosaferi, B; Najdi, N; Salari, AA; Zeraati, M, 2021) |
| "Increased behavioral manifestations and seizure severity was observed in the stress group compared with the control group at both ages." | 1.56 | Physical exercise during pregnancy minimizes PTZ-induced behavioral manifestations in prenatally stressed offspring. ( Arida, RM; da Silva, EA; Gutierre, RC; Lopim, GM, 2020) |
| "LCM and LEV were both effective against seizures induced by PTZ." | 1.46 | Treatment with lacosamide impedes generalized seizures in a rodent model of cortical dysplasia. ( Alexopoulos, AV; Gonzalez-Martinez, J; Najm, IM; Nemes, AD; O'Dwyer, R; Ying, Z, 2017) |
| "Body weight was significantly higher in morphine groups than saline treated rats." | 1.40 | Effect of prenatal forced-swim stress and morphine co-administration on pentylentetrazol-induced epileptic behaviors in infant and prepubertal rats. ( Ebrahimi, L; Hashemi, P; Roshan-Milani, S; Saboory, E, 2014) |
| "The present study showed that epileptic seizures induced by convulsive PTZ challenge during kindling-mediated epileptogenesis in the presence of CD changed both functional and ultrastructural properties of the BBB and considerably enhanced transendothelial vesicular transport, while paracellular pathway was apparently not involved in this setting." | 1.35 | Morphological and functional changes of blood-brain barrier in kindled rats with cortical dysplasia. ( Ahishali, B; Arican, N; Bilgic, B; Ekizoglu, O; Elmas, I; Gurses, C; Kalayci, R; Kaya, M; Kemikler, G; Kucuk, M; Oku, B; Orhan, N; Ustek, D, 2008) |
| "Following cocaine-induced seizures, intense c-fos induction was observed in piriform cortex, amygdala, and hippocampus." | 1.31 | Spatiotemporal analysis of Fos expression associated with cocaine- and PTZ-induced seizures in prenatally cocaine-treated rats. ( Keller, RW; Snyder-Keller, A, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 8 (50.00) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Lopim, GM | 1 |
| Gutierre, RC | 1 |
| da Silva, EA | 1 |
| Arida, RM | 1 |
| Yavuz, M | 1 |
| Albayrak, N | 1 |
| Özgür, M | 1 |
| Gülçebi İdriz Oğlu, M | 1 |
| Çavdar, S | 1 |
| Onat, F | 1 |
| Zeraati, M | 1 |
| Najdi, N | 1 |
| Mosaferi, B | 1 |
| Salari, AA | 1 |
| Nemes, AD | 1 |
| O'Dwyer, R | 1 |
| Najm, IM | 1 |
| Ying, Z | 1 |
| Gonzalez-Martinez, J | 1 |
| Alexopoulos, AV | 1 |
| Ebrahimi, L | 2 |
| Saboory, E | 2 |
| Roshan-Milani, S | 2 |
| Hashemi, P | 2 |
| Naseer, MI | 1 |
| Ullah, I | 1 |
| Rasool, M | 1 |
| Ansari, SA | 1 |
| Sheikh, IA | 1 |
| Bibi, F | 1 |
| Chaudhary, AG | 1 |
| Al-Qahtani, MH | 1 |
| Kim, MO | 1 |
| Gilbert, ME | 1 |
| Ramos, RL | 1 |
| McCloskey, DP | 1 |
| Goodman, JH | 1 |
| Pourmotabbed, A | 1 |
| Mahmoodi, G | 1 |
| Mahmoodi, S | 1 |
| Mohammadi-Farani, A | 1 |
| Nedaei, SE | 1 |
| Pourmotabbed, T | 2 |
| Soltanineghad, M | 1 |
| Xie, T | 1 |
| Wang, WP | 1 |
| Jia, LJ | 1 |
| Mao, ZF | 1 |
| Qu, ZZ | 1 |
| Luan, SQ | 1 |
| Kan, MC | 1 |
| Kaya, M | 1 |
| Gurses, C | 1 |
| Kalayci, R | 1 |
| Ekizoglu, O | 1 |
| Ahishali, B | 1 |
| Orhan, N | 1 |
| Oku, B | 1 |
| Arican, N | 1 |
| Ustek, D | 1 |
| Bilgic, B | 1 |
| Elmas, I | 1 |
| Kucuk, M | 1 |
| Kemikler, G | 1 |
| Koff, JM | 1 |
| Miller, LG | 1 |
| De Riu, PL | 1 |
| Mameli, P | 1 |
| Becciu, A | 1 |
| Simula, ME | 1 |
| Mameli, O | 1 |
| Snyder-Keller, A | 2 |
| Keller, RW | 2 |
| Gavish, M | 1 |
| Avnimelech-Gigus, N | 1 |
| Feldon, J | 1 |
| Myslobodsky, M | 1 |
16 other studies available for pentylenetetrazole and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Physical exercise during pregnancy minimizes PTZ-induced behavioral manifestations in prenatally stressed offspring.
Topics: Animals; Behavior, Animal; Convulsants; Disease Models, Animal; Epilepsy; Female; Male; Pentylenetet | 2020 |
The effect of prenatal and postnatal caffeine exposure on pentylentetrazole induced seizures in the non-epileptic and epileptic offsprings.
Topics: Animals; Brain; Caffeine; Calcium Channels, T-Type; Epilepsy, Absence; Female; Male; Pentylenetetraz | 2019 |
Environmental enrichment alters neurobehavioral development following maternal immune activation in mice offspring with epilepsy.
Topics: Animals; Anxiety; Behavior, Animal; Cognitive Dysfunction; Convulsants; Disease Models, Animal; Dise | 2021 |
Treatment with lacosamide impedes generalized seizures in a rodent model of cortical dysplasia.
Topics: Acetamides; Animals; Anticonvulsants; Electroencephalography; Female; GABA Antagonists; Lacosamide; | 2017 |
Effect of prenatal forced-swim stress and morphine co-administration on pentylentetrazol-induced epileptic behaviors in infant and prepubertal rats.
Topics: Animals; Animals, Newborn; Body Weight; Female; Male; Morphine; Narcotics; Pentylenetetrazole; Pregn | 2014 |
Downregulation of dopamine D₁ receptors and increased neuronal apoptosis upon ethanol and PTZ exposure in prenatal rat cortical and hippocampal neurons.
Topics: Animals; Apoptosis; Blotting, Western; Cells, Cultured; Cerebral Cortex; Convulsants; Down-Regulatio | 2014 |
Subcortical band heterotopia in rat offspring following maternal hypothyroxinaemia: structural and functional characteristics.
Topics: Animals; Brain; Classical Lissencephalies and Subcortical Band Heterotopias; Dose-Response Relations | 2014 |
Effect of central muscarinic receptors on passive-avoidance learning deficits induced by prenatal pentylenetetrazol kindling in male offspring.
Topics: Animals; Avoidance Learning; Brain; Female; Kindling, Neurologic; Learning Disabilities; Male; Musca | 2014 |
Interactive effects of prenatal exposure to restraint stress and alcohol on pentylenetetrazol-induced seizure behaviors in rat offspring.
Topics: Animals; Animals, Newborn; Corticosterone; Ethanol; Female; Male; Pentylenetetrazole; Pregnancy; Pre | 2016 |
Environmental enrichment restores cognitive deficits induced by prenatal maternal seizure.
Topics: Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Cell Count; Cognition Disorders; Convu | 2012 |
Morphological and functional changes of blood-brain barrier in kindled rats with cortical dysplasia.
Topics: Animals; Blood-Brain Barrier; Capillary Permeability; Disease Models, Animal; Female; Glial Fibrilla | 2008 |
Prenatal lorazepam exposure: 4. Persistent alterations in pentylenetetrazole-induced seizure threshold and GABA-dependent chloride uptake after prenatal lorazepam exposure.
Topics: Animals; Brain Chemistry; Chlorides; Chlorine; Female; gamma-Aminobutyric Acid; Lorazepam; Mice; Mus | 1995 |
Effect of fetal hypoxia on seizure susceptibility in rats.
Topics: Animals; Electrocardiography; Female; Fetal Hypoxia; Male; Pentylenetetrazole; Pregnancy; Prenatal E | 1995 |
Prenatal cocaine exposure increases susceptibility to drug-induced seizures. c-fos induction and brain cocaine levels.
Topics: Animals; Brain; Cocaine; Disease Susceptibility; Female; Gene Expression Regulation; Male; Pentylene | 1998 |
Spatiotemporal analysis of Fos expression associated with cocaine- and PTZ-induced seizures in prenatally cocaine-treated rats.
Topics: Animals; Brain; Cell Count; Cocaine; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitat | 2001 |
Prenatal chlordiazepoxide effects on metrazol seizures and benzodiazepine receptors density in adult albino rats.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Chlordiazepoxide; Drug Resistance; Female; Flunitrazepa | 1985 |