pentylenetetrazole has been researched along with Convulsions, Grand Mal in 74 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study was designed to investigate whether acute or subchronic treatment with coenzyme Q10 altered the seizures induced by pentylenetetrazole or electroshock in mice." | 7.80 | The effects of coenzyme Q10 on seizures in mice: the involvement of nitric oxide. ( Moezi, L; Mousavi, Z; Sattarinezhad, E; Shafaroodi, H; Sheikhnouri, K, 2014) |
| " MET test (PTZ at the dose of 70 mg/kg) acute seizures in Wistar rats, in comparison to valproic acid (VPA)." | 7.76 | Levetiracetam in submaximal subcutaneous pentylentetrazol-induced seizures in rats. ( Arcieri, S; Coppola, G; D'Aniello, A; Messana, T; Pascotto, A; Signoriello, G; Verrotti, A, 2010) |
| "Intramuscular injection of selective NMDA receptor antagonists memantine and arcaine 4-fold decreased the incidence of pentylenetetrazole-induced generalized tonic-clonic seizures in rats, while the incidence of clonic seizures decreased by 1." | 7.74 | Combined blockade of AMPA and NMDA receptors in the brain of rats prevents pentylenetetrazole-induced clonic and tonic-clonic seizures without ataxia. ( Gmiro, VE; Serdyuk, SE, 2008) |
| "To determine whether seizures have age-specific features, we studied the role of gamma-aminobutyric acidB (GABAB) transmission in rats of various ages (9, 15, 30, and 60 postnatal days)." | 7.69 | Age-specific effects of baclofen on pentylenetetrazol-induced seizures in developing rats. ( Moshé, SL; Velísek, L; Velísková, J, 1996) |
| "The action of ethosuximide (125 or 250 mg/kg, IP) against picrotoxin-induced seizures (3-6 mg/kg, IP) was assessed in rats 12, 18, 25, and 90 days old." | 7.68 | Ethosuximide suppresses seizures and lethality induced by picrotoxin in developing rats. ( Mares, P; Micianiková, D; Rokyta, R; Velísek, L; Velísková, J, 1993) |
| "The incidence of minimal, predominantly clonic seizures was not changed in any age group, but their latencies were prolonged in 18- and 25-day-old rats." | 5.31 | Does vigabatrin possess an anticonvulsant action against pentylenetetrazol-induced seizures in developing rats? ( Haugvicová, R; Kubová, H; Mares, P, 2002) |
| "Adenosine has been shown to play a significant role as a modulator of neuronal activity in convulsion disorders, acting as an endogenous anticonvulsant agent." | 5.30 | Time development and regional distribution of [3H]nitrobenzylthioinosine adenosine uptake site binding in the mouse brain after acute Pentylenetetrazol-induced seizures. ( Angelatou, F; Pagonopoulou, O, 1998) |
| " This study was designed to investigate whether acute or subchronic treatment with coenzyme Q10 altered the seizures induced by pentylenetetrazole or electroshock in mice." | 3.80 | The effects of coenzyme Q10 on seizures in mice: the involvement of nitric oxide. ( Moezi, L; Mousavi, Z; Sattarinezhad, E; Shafaroodi, H; Sheikhnouri, K, 2014) |
| " MET test (PTZ at the dose of 70 mg/kg) acute seizures in Wistar rats, in comparison to valproic acid (VPA)." | 3.76 | Levetiracetam in submaximal subcutaneous pentylentetrazol-induced seizures in rats. ( Arcieri, S; Coppola, G; D'Aniello, A; Messana, T; Pascotto, A; Signoriello, G; Verrotti, A, 2010) |
| "Intramuscular injection of selective NMDA receptor antagonists memantine and arcaine 4-fold decreased the incidence of pentylenetetrazole-induced generalized tonic-clonic seizures in rats, while the incidence of clonic seizures decreased by 1." | 3.74 | Combined blockade of AMPA and NMDA receptors in the brain of rats prevents pentylenetetrazole-induced clonic and tonic-clonic seizures without ataxia. ( Gmiro, VE; Serdyuk, SE, 2008) |
| "), status epilepticus (SE) of limbic seizures produced by kainic acid (KA, 10 mg/kg, i." | 3.73 | 5-HT1A receptor agonists modify epileptic seizures in three experimental models in rats. ( González-Trujano, ME; Hong, E; López-Meraz, ML; Neri-Bazán, L; Rocha, LL, 2005) |
| " Thresholds for producing seizures in brain-derived neurotrophic factor wild-type and brain-derived neurotrophic factor heterozygous mice were compared in several seizure models, including thresholds for electrically-induced clonic, tonic-clonic and 6 Hz limbic seizures, as well as seizures induced chemically by kainate, pilocarpine and pentylenetetrazol." | 3.73 | The seizure-related phenotype of brain-derived neurotrophic factor knockdown mice. ( Barton, ME; Shannon, HE, 2005) |
| "To determine whether seizures have age-specific features, we studied the role of gamma-aminobutyric acidB (GABAB) transmission in rats of various ages (9, 15, 30, and 60 postnatal days)." | 3.69 | Age-specific effects of baclofen on pentylenetetrazol-induced seizures in developing rats. ( Moshé, SL; Velísek, L; Velísková, J, 1996) |
| "The influence of flumazenil on seizures induced by pentylenetetrazol (PTZ) was studied in rats aged 7, 12, 18, 25, and 90 days." | 3.68 | Anticonvulsant activity of flumazenil in rats during ontogenetic development. ( Kubová, H; Mares, P; Rathouská, J; Vorlícek, J, 1993) |
| " In flurothyl-induced seizures, CA deficient mice displayed longer latencies to the onset of both clonic and tonic-clonic seizures." | 3.68 | Reduced susceptibility to seizures in carbonic anhydrase II deficient mutant mice. ( Cammer, W; Moshé, SL; Velísek, L; Xu, SG, 1993) |
| "The action of ethosuximide (125 or 250 mg/kg, IP) against picrotoxin-induced seizures (3-6 mg/kg, IP) was assessed in rats 12, 18, 25, and 90 days old." | 3.68 | Ethosuximide suppresses seizures and lethality induced by picrotoxin in developing rats. ( Mares, P; Micianiková, D; Rokyta, R; Velísek, L; Velísková, J, 1993) |
| "The anticonvulsant actions of lamotrigine and phenytoin against pentylenetetrazol-induced seizures were compared in laboratory rats during ontogenesis." | 3.68 | Anticonvulsant action of lamotrigine during ontogenesis in rats. ( Kubová, H; Mares, P; Stanková, L, 1992) |
| " Catalepsy and analgesia were found in varying degrees after maximal electroshock (MES), metrazol, picrotoxin, and Ro 5-3663 activated seizures." | 3.66 | Convulsant-specific architecture of the postictal behavior syndrome in the rat. ( Kofman, O; Mintz, M; Myslobodsky, M, 1981) |
| "Agmatine also potentiates the anti-seizure activity of morphine." | 1.39 | Role of nitric oxide in additive anticonvulsant effects of agmatine and morphine. ( Bahremand, A; Dehpour, AR; Derakhshanian, H; Ebrahimi, A; Fadakar, K; Moghaddas, P; Payandemehr, B; Rahimian, R; Saadat, S, 2013) |
| "After induction of generalized tonic-clonic seizures by PTZ there were no differences in mRNA at 24h after seizures, equaling baseline quantities except for GAD1, which was decreased." | 1.37 | Differential molecular regulation of glutamate in kindling resistant rats. ( Doi, T; Takaki, M; Ueda, Y; Willmore, LJ, 2011) |
| "Pentylenetetrazole (10mg/ml/min) was continuously infused through an intravenous catheter to induce seizures while four different patterns of temporally coded electrical stimulation were applied: periodic stimulation (PS), pseudo-randomized IPI stimulation (LH), restrictively randomized IPI stimulation (IH), and bursts of 20-ms IPIs (burst)." | 1.35 | Distinct patterns of electrical stimulation of the basolateral amygdala influence pentylenetetrazole seizure outcome. ( Cota, VR; Doretto, MC; Medeiros, Dde C; Moraes, MF; Vilela, MR, 2009) |
| "Pretreatment with bumetanide (0." | 1.35 | Age- and dose-specific anticonvulsant action of bumetanide in immature rats. ( Mares, P, 2009) |
| "Thus, concerning the seizure modulating properties of both classes of receptors this study investigated whether the ultra-low dose opioid antagonist naltrexone influences cannabinoid anticonvulsant effects." | 1.35 | The cannabinoid anticonvulsant effect on pentylenetetrazole-induced seizure is potentiated by ultra-low dose naltrexone in mice. ( Bahremand, A; Dehpour, AR; Ghasemi, M; Gholizadeh, S; Nasrabady, SE; Shafaroodi, H, 2008) |
| "Acetone has been shown to suppress experimental seizures." | 1.32 | Anticonvulsant properties of acetone, a brain ketone elevated by the ketogenic diet. ( Burnham, WM; Cortez, MA; Likhodii, SS; Murphy, P; Serbanescu, I; Snead, OC, 2003) |
| "The incidence of minimal, predominantly clonic seizures was not changed in any age group, but their latencies were prolonged in 18- and 25-day-old rats." | 1.31 | Does vigabatrin possess an anticonvulsant action against pentylenetetrazol-induced seizures in developing rats? ( Haugvicová, R; Kubová, H; Mares, P, 2002) |
| " GTCSs were suppressed by TGB in the adult and 25-day-old rats, and a U-shaped dose-response curve was outlined in these two groups." | 1.31 | Two different anticonvulsant actions of tiagabine in developing rats. ( Haugvicová, R; Kubová, H; Mares, P; Skutová, M; Suchomelová, L, 2000) |
| "From that age onwards, the seizure threshold significantly decreased and reached a minimum at PN 220." | 1.31 | PTZ-induced seizures in rats: effects of age and strain. ( Chepurnov, SA; Chepurnova, NE; Klioueva, IA; van Luijtelaar, EL, 2001) |
| " Both effects exhibited a tendency to a U-shaped dose-response curve." | 1.30 | Anticonvulsant action of gabapentin during postnatal development in rats. ( Haugvicová, R; Mares, P, 1997) |
| "Adenosine has been shown to play a significant role as a modulator of neuronal activity in convulsion disorders, acting as an endogenous anticonvulsant agent." | 1.30 | Time development and regional distribution of [3H]nitrobenzylthioinosine adenosine uptake site binding in the mouse brain after acute Pentylenetetrazol-induced seizures. ( Angelatou, F; Pagonopoulou, O, 1998) |
| "Adenosine has been shown to be a major regulator of neuronal activity in convulsive disorders, exerting its anticonvulsant effect through central A1 adenosine receptors." | 1.29 | Effect of pentylentetrazol-induced seizures on A1 adenosine receptor regional density in the mouse brain: a quantitative autoradiographic study. ( Angelatou, F; Kostopoulos, G; Pagonopoulou, O, 1993) |
| "Nitric oxide may be involved in seizure phenomena even though data often seem to be contradictory." | 1.29 | NG-nitro-L-arginine, a nitric oxide synthase inhibitor, and seizure susceptibility in four seizure models in mice. ( Borowicz, KK; Błaszczak, P; Czuczwar, SJ; Drelewska, E; Kleinrok, Z; Urbańska, EM, 1996) |
| "Ontogenetic differences in seizure thresholds to pentylenetetrazol (PTZ) were examined in young, developing rats (ages: 10, 18, 28, and 60 days)." | 1.29 | Ontogenetic development and pentylenetetrazol seizure thresholds in rats. ( Mostofsky, DI; Weller, A, 1995) |
| "Although calcium antagonists possess antiepileptic properties in various models of epilepsy, their role after chronic administration and in models for generalized absence epilepsy has not been studied." | 1.29 | The effects of chronic treatment with a calcium channel antagonist on two types of generalized epilepsies in rats. ( Ates, N; van der Staay, FJ; van Luijtelaar, EL, 1994) |
| "Seizures were induced by PTZ in doses from 40 to 120 mg/kg s." | 1.28 | Pentylenetetrazol-induced seizures in rats: an ontogenetic study. ( Kubova, H; Mares, P; Pohl, M; Schickerova, R; Stankova, L; Velisek, L, 1992) |
| "We have recently shown that seizures induce significant and sustained elevations of thyrotropin-releasing hormone (TRH) in specific extrahypothalamic rat brain regions associated with epileptic foci including amygdala, hippocampus, pyriform cortex, and anterior cortex." | 1.28 | Regional changes in central nervous system thyrotropin-releasing hormone after pentylenetetrazol-induced seizures in dogs. ( Durbin, S; Goodwin, S; Javed, T; Kubek, M; Sanders, S; Shapiro, S, 1992) |
| "Ethyl acetate produced generalized clonic seizures and deaths at high doses and was ineffective to prevent electroshock- and PTZ-induced seizures at low doses." | 1.28 | Anticonvulsant and convulsant effects of organic solvents. ( Pires, ML; Shiotsuki, N; Silva-Filho, AR, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (14.86) | 18.7374 |
| 1990's | 29 (39.19) | 18.2507 |
| 2000's | 22 (29.73) | 29.6817 |
| 2010's | 12 (16.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Oliveira, JC | 1 |
| Maciel, RM | 1 |
| Moraes, MFD | 1 |
| Rosa Cota, V | 1 |
| Silva, LF | 1 |
| Hoffmann, MS | 1 |
| Gerbatin, Rda R | 1 |
| Fiorin, Fda S | 1 |
| Dobrachinski, F | 1 |
| Mota, BC | 1 |
| Wouters, AT | 1 |
| Pavarini, SP | 1 |
| Soares, FA | 1 |
| Fighera, MR | 1 |
| Royes, LF | 1 |
| Payandemehr, B | 1 |
| Rahimian, R | 1 |
| Bahremand, A | 2 |
| Ebrahimi, A | 1 |
| Saadat, S | 1 |
| Moghaddas, P | 1 |
| Fadakar, K | 1 |
| Derakhshanian, H | 1 |
| Dehpour, AR | 3 |
| Godoy, LD | 1 |
| Liberato, JL | 1 |
| da Silva Junior, PI | 1 |
| dos Santos, WF | 1 |
| Erdogan, H | 1 |
| Ekici, F | 2 |
| Katar, M | 1 |
| Kesici, H | 1 |
| Aslan, H | 1 |
| Sattarinezhad, E | 1 |
| Shafaroodi, H | 3 |
| Sheikhnouri, K | 1 |
| Mousavi, Z | 1 |
| Moezi, L | 2 |
| Gürol, G | 1 |
| Ateş, N | 4 |
| Sahin, D | 1 |
| Ilbay, G | 1 |
| Imal, M | 1 |
| Bozdogan, O | 1 |
| Cota, VR | 1 |
| Medeiros, Dde C | 1 |
| Vilela, MR | 1 |
| Doretto, MC | 1 |
| Moraes, MF | 1 |
| Gmiro, VE | 1 |
| Serdyuk, SE | 1 |
| Akula, KK | 1 |
| Dhir, A | 1 |
| Kulkarni, SK | 1 |
| Mares, P | 15 |
| Coppola, G | 1 |
| Arcieri, S | 1 |
| D'Aniello, A | 1 |
| Messana, T | 1 |
| Verrotti, A | 1 |
| Signoriello, G | 1 |
| Pascotto, A | 1 |
| González-Ramírez, M | 1 |
| Razo-Juárez, LI | 1 |
| Sauer-Ramírez, JL | 1 |
| González-Trujano, ME | 2 |
| Salgado-Ceballos, H | 1 |
| Orozco-Suarez, S | 1 |
| Doi, T | 1 |
| Ueda, Y | 1 |
| Takaki, M | 1 |
| Willmore, LJ | 1 |
| de Oliveira, RC | 1 |
| de Oliveira, R | 1 |
| Zanandréa, PC | 1 |
| Paschoalin-Maurin, T | 1 |
| Coimbra, NC | 2 |
| Fakhrzad, A | 1 |
| Hassanipour, M | 1 |
| Rezayat, M | 1 |
| Koryntová, H | 1 |
| Kubová, H | 8 |
| Tutka, P | 1 |
| Eraković, V | 1 |
| Zupan, G | 1 |
| Varljen, J | 1 |
| Simonić, A | 1 |
| Haugvicová, R | 5 |
| Likhodii, SS | 1 |
| Serbanescu, I | 1 |
| Cortez, MA | 1 |
| Murphy, P | 1 |
| Snead, OC | 1 |
| Burnham, WM | 2 |
| JERVIS, G | 1 |
| SERGIO, C | 1 |
| FREY, HH | 1 |
| Mikulecká, A | 1 |
| Akman, O | 1 |
| Karson, A | 1 |
| López-Meraz, ML | 1 |
| Neri-Bazán, L | 1 |
| Hong, E | 1 |
| Rocha, LL | 1 |
| Akbas, SH | 1 |
| Yegin, A | 1 |
| Ozben, T | 1 |
| Barton, ME | 1 |
| Shannon, HE | 1 |
| Kasal, A | 1 |
| Perez-Cruz, C | 1 |
| Likhodii, S | 1 |
| Nassiri-Asl, M | 1 |
| Shariati-Rad, S | 1 |
| Zamansoltani, F | 1 |
| Ghasemi, M | 1 |
| Nasrabady, SE | 1 |
| Gholizadeh, S | 1 |
| Myslobodsky, M | 1 |
| Kofman, O | 1 |
| Mintz, M | 1 |
| Velísek, L | 6 |
| Vachová, D | 2 |
| Weller, A | 1 |
| Mostofsky, DI | 1 |
| Asai, M | 1 |
| Talavera, E | 1 |
| Massarini, A | 1 |
| Zubieta, M | 1 |
| Vindrola, O | 1 |
| Brady, LS | 1 |
| Lynn, AB | 1 |
| Glowa, JR | 1 |
| Le, DQ | 1 |
| Herkenham, M | 1 |
| van Luijtelaar, EL | 2 |
| van der Staay, FJ | 1 |
| Mehndiratta, MM | 1 |
| Rohatgi, A | 1 |
| Husain, S | 1 |
| Kumar, N | 1 |
| Seidl, J | 1 |
| Nováková, J | 1 |
| Pagonopoulou, O | 2 |
| Angelatou, F | 2 |
| Kostopoulos, G | 1 |
| Rathouská, J | 1 |
| Vorlícek, J | 1 |
| Moshé, SL | 2 |
| Xu, SG | 1 |
| Cammer, W | 1 |
| Velísková, J | 2 |
| Rokyta, R | 1 |
| Micianiková, D | 1 |
| Urbańska, EM | 1 |
| Drelewska, E | 1 |
| Borowicz, KK | 1 |
| Błaszczak, P | 1 |
| Kleinrok, Z | 1 |
| Czuczwar, SJ | 1 |
| Georgiev, VP | 1 |
| Tchekalarova, JD | 1 |
| Akarsu, ES | 1 |
| Mamuk, S | 1 |
| Comert, A | 1 |
| Giménez-Llort, L | 1 |
| De Vera, N | 1 |
| Martínez, E | 1 |
| Skutová, M | 2 |
| Suchomelová, L | 1 |
| Klioueva, IA | 1 |
| Chepurnova, NE | 1 |
| Chepurnov, SA | 1 |
| Freitas, RL | 1 |
| Savoldi, M | 1 |
| Castro-Souza, C | 1 |
| Segato, EN | 1 |
| Kishi, R | 1 |
| Weltson, A | 1 |
| Resende, GC | 1 |
| Arushanian, EB | 1 |
| Vol'f, MSh | 1 |
| Halonen, T | 1 |
| Pitkänen, A | 1 |
| Partanen, J | 1 |
| Hyttinen, JM | 1 |
| Riekkinen, PJ | 1 |
| Shapiro, S | 1 |
| Kubek, M | 1 |
| Sanders, S | 1 |
| Durbin, S | 1 |
| Goodwin, S | 1 |
| Javed, T | 1 |
| Pohl, M | 1 |
| Stankova, L | 2 |
| Schickerova, R | 1 |
| Silva-Filho, AR | 1 |
| Pires, ML | 1 |
| Shiotsuki, N | 1 |
| Karbon, EW | 1 |
| Enna, SJ | 1 |
| Ferkany, JW | 1 |
| Woodbury, JW | 1 |
| Woodbury, DM | 1 |
| Naquet, R | 1 |
| Enginar, N | 1 |
| Eroğlu, L | 1 |
| Fischer, W | 1 |
| Browne, TR | 1 |
| Penry, JK | 1 |
| Crist, RD | 1 |
| Parellada, PP | 1 |
| Goldring, S | 1 |
| Jinnai, D | 1 |
| Roth, B | 1 |
| Stein, J | 1 |
| Schulz, H | 1 |
| Müllerová, J | 1 |
| de Biolley, D | 1 |
| Sorel, L | 1 |
1 review available for pentylenetetrazole and Convulsions, Grand Mal
| Article | Year |
|---|---|
Benzodiazepines in the treatment of epilepsy. A review.
Topics: Adult; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Disease Models, Animal; Eclampsia; Elec | 1973 |
73 other studies available for pentylenetetrazole and Convulsions, Grand Mal
| Article | Year |
|---|---|
Asynchronous, bilateral, and biphasic temporally unstructured electrical stimulation of amygdalae enhances the suppression of pentylenetetrazole-induced seizures in rats.
Topics: Amygdala; Animals; Cortical Synchronization; Deep Brain Stimulation; Disease Models, Animal; Drug Re | 2018 |
Treadmill exercise protects against pentylenetetrazol-induced seizures and oxidative stress after traumatic brain injury.
Topics: Animals; Brain; Brain Chemistry; Brain Injuries; Convulsants; Electrodes, Implanted; Electroencephal | 2013 |
Role of nitric oxide in additive anticonvulsant effects of agmatine and morphine.
Topics: Agmatine; Animals; Anticonvulsants; Arginine; Convulsants; Dose-Response Relationship, Drug; Enzyme | 2013 |
Mygalin: a new anticonvulsant polyamine in acute seizure model and neuroethological schedule.
Topics: Acute Disease; Animals; Anticonvulsants; Cognition; Diazepam; Dizocilpine Maleate; Drug Evaluation, | 2013 |
The protective effects of endothelin-A receptor antagonist BQ-123 in pentylenetetrazole-induced seizure in rats.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Endothelin A Receptor Antagonists; Epilepsy | 2014 |
The effects of coenzyme Q10 on seizures in mice: the involvement of nitric oxide.
Topics: Animals; Arginine; Brain; Disease Models, Animal; Electroshock; Epilepsy, Tonic-Clonic; Guanidines; | 2014 |
Effects of linoleic acid on generalized convulsive and nonconvulsive epileptic seizures.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Epilepsy, Tonic-Clonic; | 2014 |
Vagus nerve stimulation suppresses generalized seizure activity and seizure-triggered postictal cardiac rhythm changes in rats.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Disease Models, Animal; Electrocardiography; Electroe | 2009 |
Distinct patterns of electrical stimulation of the basolateral amygdala influence pentylenetetrazole seizure outcome.
Topics: Amygdala; Animals; Convulsants; Electric Stimulation; Epilepsy, Tonic-Clonic; Male; Pentylenetetrazo | 2009 |
Combined blockade of AMPA and NMDA receptors in the brain of rats prevents pentylenetetrazole-induced clonic and tonic-clonic seizures without ataxia.
Topics: Animals; Ataxia; Biguanides; Drug Synergism; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Male | 2008 |
Effect of various antiepileptic drugs in a pentylenetetrazol-induced seizure model in mice.
Topics: Adenosine; Algorithms; Animals; Anti-Inflammatory Agents; Anticonvulsants; Barbiturates; Carbamazepi | 2009 |
Age- and dose-specific anticonvulsant action of bumetanide in immature rats.
Topics: Age Factors; Aging; Animals; Anticonvulsants; Bumetanide; Disease Models, Animal; Dose-Response Rela | 2009 |
Levetiracetam in submaximal subcutaneous pentylentetrazol-induced seizures in rats.
Topics: Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Electroshock; Epilepsy, Gen | 2010 |
Anticonvulsive effect of vitamin C on pentylenetetrazol-induced seizures in immature rats.
Topics: Animals; Anticonvulsants; Ascorbic Acid; Aspartic Acid; Brain Chemistry; Chromatography, High Pressu | 2010 |
Differential molecular regulation of glutamate in kindling resistant rats.
Topics: Animals; Convulsants; DNA Primers; Electric Stimulation; Epilepsy, Tonic-Clonic; Glutamic Acid; Hipp | 2011 |
Acetylcholine-mediated neurotransmission within the nucleus raphe magnus exerts a key role in the organization of both interictal and postictal antinociception.
Topics: Acetylcholine; Animals; Atropine; Cholinergic Agonists; Cholinergic Antagonists; Disease Models, Ani | 2011 |
The involvement of nitric oxide in the anti-seizure effect of acute atorvastatin treatment in mice.
Topics: Animals; Anticonvulsants; Atorvastatin; Brain; Convulsants; Disease Models, Animal; Dose-Response Re | 2012 |
Changes of cortical epileptic afterdischarges under the influence of convulsant drugs.
Topics: Animals; Caffeine; Cerebral Cortex; Convulsants; Electric Stimulation; Electroencephalography; Epile | 2002 |
Pentylenetetrazol-induced seizures and kindling: changes in free fatty acids, superoxide dismutase, and glutathione peroxidase activity.
Topics: Animals; Brain; Cerebellum; Epilepsy, Tonic-Clonic; Fatty Acids, Nonesterified; Female; Glutathione | 2003 |
Does vigabatrin possess an anticonvulsant action against pentylenetetrazol-induced seizures in developing rats?
Topics: Animals; Animals, Newborn; Anticonvulsants; Convulsants; Epilepsy, Generalized; Epilepsy, Tonic-Clon | 2002 |
Anticonvulsant properties of acetone, a brain ketone elevated by the ketogenic diet.
Topics: Acetone; Amygdala; Animals; Anticonvulsants; Ataxia; Brain Chemistry; Convulsants; Diabetes Mellitus | 2003 |
[PERMANENT DEFICIENCY OF FIXATION MEMORY AFTER UNILATERAL TEMPORAL LOBECTOMY IN AN EPILEPTIC SUBJECT].
Topics: Amnesia; Bemegride; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Cloni | 1964 |
NOTE ON THE INTERACTIONS OF AMPHETAMINE WITH ANTICONVULSANT DRUGS.
Topics: Amphetamine; Amphetamines; Animals; Anticonvulsants; Electricity; Electroshock; Epilepsy; Epilepsy, | 1964 |
MPEP, an antagonist of metabotropic glutamate receptors, exhibits anticonvulsant action in immature rats without a serious impairment of motor performance.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Ep | 2004 |
The effects of the immature rat model of febrile seizures on the occurrence of later generalized tonic-clonic and absence epilepsy.
Topics: Action Potentials; Animals; Animals, Newborn; Brain; Causality; Convulsants; Disease Models, Animal; | 2005 |
5-HT1A receptor agonists modify epileptic seizures in three experimental models in rats.
Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Animals; Anticonvulsants; Con | 2005 |
Effect of pentylenetetrazol-induced epileptic seizure on the antioxidant enzyme activities, glutathione and lipid peroxidation levels in rat erythrocytes and liver tissues.
Topics: Animals; Antioxidants; Catalase; Epilepsy, Tonic-Clonic; Erythrocytes; Female; Glucosephosphate Dehy | 2005 |
The seizure-related phenotype of brain-derived neurotrophic factor knockdown mice.
Topics: Alleles; Amygdala; Animals; Brain-Derived Neurotrophic Factor; Convulsants; Electric Stimulation; El | 2005 |
Action of two neuroactive steroids against motor seizures induced by pentetrazol in rats during ontogeny.
Topics: Age Factors; Anesthetics; Animals; Animals, Newborn; Convulsants; Desoxycorticosterone; Epilepsy, Ge | 2006 |
Deoxycorticosterone's anticonvulsant effects in infant rats are blocked by finasteride, but not by indomethacin.
Topics: Animals; Animals, Newborn; Anticonvulsants; Desoxycorticosterone; Disease Models, Animal; Dose-Respo | 2006 |
Anticonvulsive effects of intracerebroventricular administration of rutin in rats.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clon | 2008 |
The cannabinoid anticonvulsant effect on pentylenetetrazole-induced seizure is potentiated by ultra-low dose naltrexone in mice.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoids; Convulsant | 2008 |
Convulsant-specific architecture of the postictal behavior syndrome in the rat.
Topics: Animals; Behavior, Animal; Benzodiazepinones; Catatonia; Convulsants; Disease Models, Animal; Electr | 1981 |
Kainate/AMPA receptor antagonists are anticonvulsant against the tonic hindlimb component of pentylenetetrazol-induced seizures in developing rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Anticonvulsants; Behavior, Animal; Epilepsy, T | 1995 |
Ontogenetic development and pentylenetetrazol seizure thresholds in rats.
Topics: Aging; Animals; Behavior, Animal; Epilepsy, Tonic-Clonic; Female; Male; Pentylenetetrazole; Rats; Ra | 1995 |
Valproic acid-induced rapid changes of met-enkephalin levels in rat brain. Probable association with abstinence behavior and anticonvulsant activity.
Topics: Animals; Anticonvulsants; Brain Chemistry; Chromatography, Gel; Chromatography, High Pressure Liquid | 1994 |
Repeated electroconvulsive shock produces long-lasting increases in messenger RNA expression of corticotropin-releasing hormone and tyrosine hydroxylase in rat brain. Therapeutic implications.
Topics: Analysis of Variance; Animals; Brain; Corticotropin-Releasing Hormone; Electroconvulsive Therapy; El | 1994 |
The effects of chronic treatment with a calcium channel antagonist on two types of generalized epilepsies in rats.
Topics: Animals; Calcium Channel Blockers; Diet; Electroencephalography; Epilepsy, Absence; Epilepsy, Genera | 1994 |
Leptazol-induced seizures.
Topics: Adult; Epilepsy, Tonic-Clonic; Humans; Male; Pentylenetetrazole; Phenytoin | 1994 |
Differential action of phenytoin and carbamazepine on cortical interhemispheric responses in young but not in adult rats.
Topics: Aging; Analysis of Variance; Animals; Carbamazepine; Electric Stimulation; Epilepsy, Tonic-Clonic; M | 1993 |
Effect of pentylentetrazol-induced seizures on A1 adenosine receptor regional density in the mouse brain: a quantitative autoradiographic study.
Topics: Adenosine; Animals; Autoradiography; Basal Ganglia; Brain; Brain Chemistry; Epilepsy, Tonic-Clonic; | 1993 |
Anticonvulsant activity of flumazenil in rats during ontogenetic development.
Topics: Aging; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Female; F | 1993 |
Reduced susceptibility to seizures in carbonic anhydrase II deficient mutant mice.
Topics: Acoustic Stimulation; Animals; Carbonic Anhydrases; Disease Susceptibility; Epilepsy, Tonic-Clonic; | 1993 |
Ethosuximide suppresses seizures and lethality induced by picrotoxin in developing rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; Ethosuxim | 1993 |
Age-specific effects of baclofen on pentylenetetrazol-induced seizures in developing rats.
Topics: Age Factors; Animals; Animals, Newborn; Baclofen; Dose-Response Relationship, Drug; Epilepsy, Tonic- | 1996 |
NG-nitro-L-arginine, a nitric oxide synthase inhibitor, and seizure susceptibility in four seizure models in mice.
Topics: Aminooxyacetic Acid; Aminophylline; Animals; Convulsants; Drug Synergism; Electroshock; Enzyme Inhib | 1996 |
Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. IV. Effects of CGP 39551.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Convulsants; Drug Evaluation, Preclinical; Ep | 1997 |
Interaction of angiotensin II and adenosine receptors in pentylenetetrazol-induced kindling in mice.
Topics: Analysis of Variance; Angiotensin II; Animals; Convulsants; Epilepsy, Tonic-Clonic; Kindling, Neurol | 1998 |
Inhibition of pentylenetetrazol-induced seizures in rats by prostaglandin D2.
Topics: Animals; Anticonvulsants; Cerebral Ventricles; Dinoprost; Epilepsy, Tonic-Clonic; Injections, Intrav | 1998 |
Anticonvulsant action of gabapentin during postnatal development in rats.
Topics: Acetates; Amines; Animals; Anticonvulsants; Behavior, Animal; Brain; Cyclohexanecarboxylic Acids; Do | 1997 |
Analysis of chemically-induced alterations of the motor activity in rats.
Topics: 4-Aminopyridine; Animals; Convulsants; Epilepsy, Tonic-Clonic; Kainic Acid; Male; Motor Activity; Pe | 1998 |
Time development and regional distribution of [3H]nitrobenzylthioinosine adenosine uptake site binding in the mouse brain after acute Pentylenetetrazol-induced seizures.
Topics: Adenosine; Affinity Labels; Animals; Autoradiography; Binding Sites; Brain; Cell Membrane; Cerebellu | 1998 |
Anticonvulsant action of topiramate against motor seizures in developing rats.
Topics: Age Factors; Animals; Anticonvulsants; Behavior, Animal; Brain; Disease Models, Animal; Epilepsy, Ge | 2000 |
Two different anticonvulsant actions of tiagabine in developing rats.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Dose-Respons | 2000 |
PTZ-induced seizures in rats: effects of age and strain.
Topics: Aging; Animals; Brain; Convulsants; Epilepsy, Tonic-Clonic; Male; Pentylenetetrazole; Rats; Rats, Wi | 2001 |
Opioid neurotransmission in the post-ictal analgesia: involvement of mu(1)-opioid receptor.
Topics: Analgesia; Animals; Convulsants; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Naltrexone; Narcot | 2001 |
[The dual role of the caudate nucleus in regulating seizures].
Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Brain Mapping; Cats; Caudate Nucleus; Cerebral | 1975 |
[Psychotropic drugs in the clinical picture of epilepsy (review of the literature)].
Topics: Amitriptyline; Animals; Anti-Anxiety Agents; Anticonvulsants; Antipsychotic Agents; Carbamazepine; C | 1975 |
Amino acid levels in cerebrospinal fluid of rats after administration of pentylenetetrazol.
Topics: Amino Acids; Animals; Catheterization; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, Toni | 1992 |
Regional changes in central nervous system thyrotropin-releasing hormone after pentylenetetrazol-induced seizures in dogs.
Topics: Amygdala; Animals; Dogs; Electroencephalography; Epilepsy, Tonic-Clonic; Frontal Lobe; Infusions, In | 1992 |
Pentylenetetrazol-induced seizures in rats: an ontogenetic study.
Topics: Aging; Animals; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Injections, Subcutaneous; | 1992 |
Anticonvulsant action of lamotrigine during ontogenesis in rats.
Topics: Aging; Animals; Anticonvulsants; Epilepsy, Tonic-Clonic; Injections, Intraperitoneal; Lamotrigine; M | 1992 |
Anticonvulsant and convulsant effects of organic solvents.
Topics: Acetates; Animals; Anticonvulsants; Convulsants; Electroshock; Epilepsy, Tonic-Clonic; Hexanes; Leth | 1992 |
Biochemical and behavioral studies following subchronic administration of GABA uptake inhibitors in mice.
Topics: Animals; Anticonvulsants; Catalepsy; Epilepsy, Tonic-Clonic; gamma-Aminobutyric Acid; Male; Mice; Mi | 1991 |
Vagal stimulation reduces the severity of maximal electroshock seizures in intact rats: use of a cuff electrode for stimulating and recording.
Topics: Action Potentials; Animals; Autonomic Fibers, Preganglionic; Electric Stimulation Therapy; Electroca | 1991 |
Epileptic manifestations and influence on sleep in the baboon Papio papio.
Topics: Animals; Cerebral Cortex; Electroencephalography; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Tonic-C | 1991 |
The effect of ofloxacin and ciprofloxacin on pentylenetetrazol-induced convulsions in mice.
Topics: Animals; Ciprofloxacin; Diazepam; Epilepsy, Tonic-Clonic; Male; Mice; Ofloxacin; Pentylenetetrazole | 1991 |
[The anticonvulsant action of 5-hydroxy-L-tryptophan in various seizure models in the mouse].
Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Electroshock; Epilepsy, Generalized; Epilepsy, Tonic- | 1991 |
Central nervous system toxic manifestations of sodium cyanate.
Topics: Age Factors; Animals; Behavior, Animal; Brain; Cyanates; Epilepsy; Epilepsy, Tonic-Clonic; Pentylene | 1974 |
The role of prefrontal cortex in grand mal convulsion.
Topics: Adolescent; Adult; Electroencephalography; Epilepsy, Tonic-Clonic; Female; Frontal Lobe; Humans; Mal | 1972 |
Clinical results and the significance of Forel-H-tomy in the treatment of epilepsy.
Topics: Animals; Cats; Cerebral Cortex; Cryosurgery; Electroencephalography; Epilepsy, Tonic-Clonic; Follow- | 1966 |
[Electroencephalographic study of cardiazol convulsion in psychotics during anesthesia and relaxation. Attempt at a neurophysiological analysis and comparison with epileptic convulsion of the grand mal type].
Topics: Anesthesia, General; Convulsive Therapy; Electroencephalography; Epilepsy, Tonic-Clonic; Humans; Met | 1968 |
[Experimental and clinical results of a new anti-epileptic: sodium di-n-propyl acetate (DPA) specialized under the marketed name, Depakine. Second study].
Topics: Acetates; Adolescent; Animals; Anticonvulsants; Behavior; Child; Child, Preschool; Electroencephalog | 1969 |