pentylenetetrazole has been researched along with Convulsions, Febrile in 18 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Epilepsy was induced in rats by injecting Pentylenetetrazole at 35 mg/kg every other day." | 7.96 | Glutamatergic pathway in depressive-like behavior associated with pentylenetetrazole rat model of epilepsy with history of prolonged febrile seizures. ( Alese, OO; Mabandla, MV; Mkhize, NV; Ngoupaye, GT; Rakgantsho, C; Zulu, S, 2020) |
| "Epilepsy is a debilitating neurological illness that affects all aspect of an individual life." | 5.56 | Prolonged febrile seizure history exacerbates seizure severity in a pentylenetetrazole rat model of epilepsy. ( Alese, OO; Mabandla, MV; Mkhize, NV; Rakgantsho, C; Zulu, S, 2020) |
| "Epilepsy was induced in rats by injecting Pentylenetetrazole at 35 mg/kg every other day." | 3.96 | Glutamatergic pathway in depressive-like behavior associated with pentylenetetrazole rat model of epilepsy with history of prolonged febrile seizures. ( Alese, OO; Mabandla, MV; Mkhize, NV; Ngoupaye, GT; Rakgantsho, C; Zulu, S, 2020) |
| " AR-R 15896AR prevented tonic seizures in rodents for up to 6 to 8 h in response to maximal electroshock (MES), 4-aminopyridine, bicuculline, or strychnine, as well as characteristic seizures following injections of N-methyl-DL-aspartic or kainic acids." | 3.70 | [S]-AR-R 15896AR-A novel anticonvulsant: acute safety, pharmacokinetic and pharmacodynamic properties. ( Balestra, M; Borrelli, AR; Cramer, CL; Eismann, MS; Freedman, LR; Hudzik, TJ; Knowles, MK; Mahmood, N; McCarthy, DJ; Murray, RJ; Palmer, GC; Stagnitto, ML, 1999) |
| "Inflammation is considered to be involved in epileptogenesis." | 1.91 | Inflammation as a target for the treatment of fever-associated epilepsy in zebrafish larvae. ( Liang, W; Shen, D; Shen, Y; Sui, J; Wang, J; Wu, Y; Yun, F; Zhang, Q; Zhou, J, 2023) |
| "Epilepsy is a debilitating neurological illness that affects all aspect of an individual life." | 1.56 | Prolonged febrile seizure history exacerbates seizure severity in a pentylenetetrazole rat model of epilepsy. ( Alese, OO; Mabandla, MV; Mkhize, NV; Rakgantsho, C; Zulu, S, 2020) |
| "Febrile seizure is a common neurological disorder observed in neonates." | 1.51 | Protective effects of M8‑B, a TRPM8 antagonist, on febrile‑ and pentylenetetrazol‑induced seizures. ( Moghimi, A; Roohbakhsh, A; Zandi, N; Zaniani, NR, 2019) |
| "Increased frequency of the experimental febrile seizures facilitated PTZ-induced generalized clonic seizures." | 1.40 | Role of TRPV1 in susceptibility to PTZ-induced seizure following repeated hyperthermia challenges in neonatal mice. ( He, XH; Kong, WL; Li, JX; Liu, YL; Min, JW; Peng, BW, 2014) |
| "Latency and probability of PTZ-induced seizures were shorter and higher respectively, in hyperthermia-treated animals compared to controls." | 1.40 | Cognitive performance and convulsion risk after experimentally-induced febrile-seizures in rat. ( Abdeen, Z; Al Shawaaf, F; Al-Ansari, S; Alsaffar, Y; Hassan, Z; Kamal, A; Mandeel, M; Rajab, E, 2014) |
| "Previous models for febrile convulsions have used environmentally induced hyperthermia as the stimulus to induce convulsions." | 1.27 | Changes in response to metrazole during fever in juvenile rats; a new model for febrile convulsions? ( Baird-Lambert, J; Buchanan, N; MacKintosh, DA, 1984) |
| "In this study the pentetrazole seizure threshold of dogs was compared with the concentration of GABA in the CSF and blood plasma." | 1.26 | Relationship between GABA concentrations in cerebrospinal fluid and seizure excitability. ( Löscher, W, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (22.22) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 3 (16.67) | 29.6817 |
| 2010's | 7 (38.89) | 24.3611 |
| 2020's | 3 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Liang, W | 1 |
| Wang, J | 1 |
| Sui, J | 1 |
| Yun, F | 1 |
| Shen, Y | 1 |
| Zhou, J | 1 |
| Wu, Y | 1 |
| Shen, D | 1 |
| Zhang, Q | 1 |
| Alese, OO | 2 |
| Rakgantsho, C | 2 |
| Mkhize, NV | 2 |
| Zulu, S | 2 |
| Mabandla, MV | 2 |
| Ngoupaye, GT | 1 |
| Zandi, N | 1 |
| Zaniani, NR | 1 |
| Moghimi, A | 1 |
| Roohbakhsh, A | 1 |
| Medina-Ceja, L | 1 |
| Villalpando-Vargas, F | 1 |
| Girón de la Cruz, GI | 1 |
| Lara-Vazquez, AM | 1 |
| Flores-Mancilla, L | 1 |
| Salazar-Sánchez, JC | 1 |
| Morales-Villagrán, A | 1 |
| Kong, WL | 1 |
| Min, JW | 1 |
| Liu, YL | 1 |
| Li, JX | 1 |
| He, XH | 1 |
| Peng, BW | 1 |
| Rajab, E | 1 |
| Abdeen, Z | 1 |
| Hassan, Z | 1 |
| Alsaffar, Y | 1 |
| Mandeel, M | 1 |
| Al Shawaaf, F | 1 |
| Al-Ansari, S | 1 |
| Kamal, A | 1 |
| Witsch, J | 1 |
| Golkowski, D | 1 |
| Hahn, TT | 1 |
| Petrou, S | 1 |
| Spors, H | 1 |
| Ohno, Y | 1 |
| Sofue, N | 1 |
| Ishihara, S | 1 |
| Mashimo, T | 1 |
| Sasa, M | 1 |
| Serikawa, T | 1 |
| Wilhelm, EA | 1 |
| Souza, AC | 1 |
| Gai, BM | 1 |
| Chagas, PM | 1 |
| Roehrs, JA | 1 |
| Nogueira, CW | 1 |
| Heida, JG | 1 |
| Boissé, L | 1 |
| Pittman, QJ | 1 |
| Ateş, N | 1 |
| Akman, O | 1 |
| Karson, A | 1 |
| van Gassen, KL | 1 |
| Hessel, EV | 1 |
| Ramakers, GM | 1 |
| Notenboom, RG | 1 |
| Wolterink-Donselaar, IG | 1 |
| Brakkee, JH | 1 |
| Godschalk, TC | 1 |
| Qiao, X | 1 |
| Spruijt, BM | 1 |
| van Nieuwenhuizen, O | 1 |
| de Graan, PN | 1 |
| MacKintosh, DA | 1 |
| Baird-Lambert, J | 1 |
| Buchanan, N | 1 |
| McCaughran, JA | 2 |
| Manetto, C | 1 |
| Schechter, N | 1 |
| Löscher, W | 1 |
| Palmer, GC | 1 |
| Murray, RJ | 1 |
| Cramer, CL | 1 |
| Stagnitto, ML | 1 |
| Knowles, MK | 1 |
| Freedman, LR | 1 |
| Eismann, MS | 1 |
| Mahmood, N | 1 |
| Balestra, M | 1 |
| Borrelli, AR | 1 |
| Hudzik, TJ | 1 |
| McCarthy, DJ | 1 |
18 other studies available for pentylenetetrazole and Convulsions, Febrile
| Article | Year |
|---|---|
Inflammation as a target for the treatment of fever-associated epilepsy in zebrafish larvae.
Topics: Animals; Disease Models, Animal; Epilepsy; Fever; Humans; Inflammation; Interleukin-1beta; Interleuk | 2023 |
Prolonged febrile seizure history exacerbates seizure severity in a pentylenetetrazole rat model of epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Glial Fibrillary Acidic Protein; Hippocampus; Male; Penty | 2020 |
Glutamatergic pathway in depressive-like behavior associated with pentylenetetrazole rat model of epilepsy with history of prolonged febrile seizures.
Topics: Amygdala; Animals; Brain-Derived Neurotrophic Factor; Depression; Epilepsy; Excitatory Amino Acid Tr | 2020 |
Protective effects of M8‑B, a TRPM8 antagonist, on febrile‑ and pentylenetetrazol‑induced seizures.
Topics: Animals; Animals, Newborn; Anticonvulsants; Body Temperature; Convulsants; Disease Models, Animal; D | 2019 |
Effect of Chronic Krill Oil Supplement on Seizures Induced by Pentylenetetrazole in the Hippocampus of Adult Rats with Previous Febrile Seizures.
Topics: Animals; Anticonvulsants; Connexin 43; Connexins; Dietary Supplements; DNA-Binding Proteins; Euphaus | 2019 |
Role of TRPV1 in susceptibility to PTZ-induced seizure following repeated hyperthermia challenges in neonatal mice.
Topics: Analysis of Variance; Animals; Animals, Newborn; Convulsants; Disease Models, Animal; Dose-Response | 2014 |
Cognitive performance and convulsion risk after experimentally-induced febrile-seizures in rat.
Topics: Analysis of Variance; Animals; Cognition Disorders; Convulsants; Disease Models, Animal; Dose-Respon | 2014 |
Cortical alterations in a model for absence epilepsy and febrile seizures: in vivo findings in mice carrying a human GABA(A)R gamma2 subunit mutation.
Topics: Action Potentials; Animals; Cerebral Cortex; Convulsants; Disease Models, Animal; Epilepsy, Absence; | 2015 |
Scn1a missense mutation impairs GABAA receptor-mediated synaptic transmission in the rat hippocampus.
Topics: Animals; Convulsants; Glutamate Decarboxylase; Hippocampus; Mutation, Missense; NAV1.1 Voltage-Gated | 2010 |
Hyperthermic seizures enhance responsiveness to pentylenetetrazole and induce cognitive dysfunction: protective effect of 3-alkynyl selenophene.
Topics: Animals; Anticonvulsants; Cognition Disorders; Convulsants; Diazepam; Hyperthermia, Induced; Male; M | 2012 |
Lipopolysaccharide-induced febrile convulsions in the rat: short-term sequelae.
Topics: Animals; Animals, Newborn; Body Temperature; Brain; Cell Death; Disease Models, Animal; Female; Feve | 2004 |
The effects of the immature rat model of febrile seizures on the occurrence of later generalized tonic-clonic and absence epilepsy.
Topics: Action Potentials; Animals; Animals, Newborn; Brain; Causality; Convulsants; Disease Models, Animal; | 2005 |
Characterization of febrile seizures and febrile seizure susceptibility in mouse inbred strains.
Topics: Animals; Behavior, Animal; Convulsants; Electrophysiology; Fever; Genetic Predisposition to Disease; | 2008 |
Changes in response to metrazole during fever in juvenile rats; a new model for febrile convulsions?
Topics: Animals; Body Temperature Regulation; Disease Models, Animal; Male; Pentylenetetrazole; Rats; Rats, | 1984 |
Potentiation of hyperthermia-induced convulsions in the developing rat by previous treatment with pentylenetetrazol.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Male; Pentylenetetrazole; Rats; Rats, Inbre | 1983 |
Experimental febrile convulsions: long-term effects of hyperthermia-induced convulsions in the developing rat.
Topics: Age Factors; Animals; Body Temperature; Growth; Hot Temperature; Myoclonus; Pentylenetetrazole; Rats | 1982 |
Relationship between GABA concentrations in cerebrospinal fluid and seizure excitability.
Topics: Animals; Dogs; Epilepsy; Female; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Seizures; Seizur | 1982 |
[S]-AR-R 15896AR-A novel anticonvulsant: acute safety, pharmacokinetic and pharmacodynamic properties.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; Electric Stimulation; Kainic Acid; Male; Mic | 1999 |