pentylenetetrazole has been researched along with Colitis in 3 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The agents tested were: alpha-lactoalbumin (ALAC), a whey protein rich in tryptophan, effective in some animal models of epilepsy and on colon/intestine inflammation, valproic acid (VPA), an effective antiepileptic drug in this seizure model, mesalazine (MSZ) an effective aminosalicylate anti-inflammatory treatment against ulcerative colitis and sodium butyrate (NaB), a short chain fatty acid (SCFA) normally produced in the intestine by gut microbiota, important in maintaining gut health and reducing gut inflammation and oxidative stress." | 3.91 | Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy. ( Avagliano, C; Calignano, A; Citraro, R; Constanti, A; De Caro, C; De Sarro, G; di Cesare Mannelli, L; Ghelardini, C; Leo, A; Mainardi, P; Nesci, V; Russo, E; Striano, P, 2019) |
| "TNBS-induced colitis increased seizure susceptibility to a subconvulsive dose of pentylenetetrazole; the immunomodulator thalidomide was protective." | 3.75 | Intestinal inflammation and seizure susceptibility: understanding the role of tumour necrosis factor-alpha in a rat model. ( Avti, PK; Chakrabarti, A; Khanduja, KL; Medhi, B; Prakash, A, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| De Caro, C | 1 |
| Leo, A | 1 |
| Nesci, V | 1 |
| Ghelardini, C | 1 |
| di Cesare Mannelli, L | 1 |
| Striano, P | 1 |
| Avagliano, C | 1 |
| Calignano, A | 1 |
| Mainardi, P | 1 |
| Constanti, A | 1 |
| Citraro, R | 1 |
| De Sarro, G | 1 |
| Russo, E | 1 |
| D'Mello, C | 1 |
| Riazi, K | 1 |
| Le, T | 1 |
| Stevens, KM | 1 |
| Wang, A | 1 |
| McKay, DM | 1 |
| Pittman, QJ | 1 |
| Swain, MG | 1 |
| Medhi, B | 1 |
| Prakash, A | 1 |
| Avti, PK | 1 |
| Chakrabarti, A | 1 |
| Khanduja, KL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Brain Activity and Oxygenation Using Near-infrared Spectroscopy (NIRS) in Inflammatory Bowel Disease (IBD) Patients[NCT04733456] | 40 participants (Anticipated) | Observational | 2021-04-26 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for pentylenetetrazole and Colitis
| Article | Year |
|---|---|
Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Colitis; Convulsants; Dextran Sul | 2019 |
P-selectin-mediated monocyte-cerebral endothelium adhesive interactions link peripheral organ inflammation to sickness behaviors.
Topics: Alanine Transaminase; Animals; Cell Adhesion; Cerebral Cortex; Cholestasis; Colitis; Cytokines; Dini | 2013 |
Intestinal inflammation and seizure susceptibility: understanding the role of tumour necrosis factor-alpha in a rat model.
Topics: Animals; Brain; Catalase; Colitis; Colon; Disease Models, Animal; Female; Glutathione Peroxidase; Li | 2009 |