pentylenetetrazole has been researched along with Cognitive Decline in 34 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effects of different doses of esculetin on epileptiform activity, behavioral seizures, memory impairment, and cortical and hippocampal NF-κB, as a mediator of pro-inflammatory gene induction, and pro-inflammatory cytokines in penicillin- and pentylenetetrazole(PTZ)-induced seizure models in rats." | 8.31 | Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats. ( Ankarali, H; Baranoglu Kilinc, Y; Danis, A; Hanci, F; Kilinc, E; Torun, IE, 2023) |
| " In the pharmacodynamic interaction study, seizures were induced using pentylenetetrazole (PTZ) (60 mg/kg, i." | 8.02 | Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats. ( Agarwal, A; Arora, R; Ganeshan N, S; Gupta, YK; Kaleekal, T; Kumar, R; Sarangi, SC, 2021) |
| "This study was conducted to evaluate the effect of embelin (EMB) on various epileptic models and related brain inflammation." | 8.02 | Embelin ameliorates cognitive dysfunction and progression of kindling in pentylenetetrazol-induced kindling in mice by attenuating brain inflammation. ( Agarwal, NB; Hoda, U; Jain, GK; Jain, S; Samim, M, 2021) |
| " The present study was designed to evaluate the effect of arbutin supplementation on seizures behavior, memory performance, glial activation, release of inflammatory factors and neuroprotection in pentylenetetrazole-induced kindling model." | 7.91 | Arbutin attenuates cognitive impairment and inflammatory response in pentylenetetrazol-induced kindling model of epilepsy. ( Ahmadian, SR; Ghasemi-Kasman, M; Pouramir, M; Sadeghi, F, 2019) |
| " Ferulic acid at doses of 75 and 100mg/kg significantly reduced the seizure score, number of myoclonic jerks, cognitive decline and oxidative stress." | 7.85 | Ferulic acid exhibits antiepileptogenic effect and prevents oxidative stress and cognitive impairment in the kindling model of epilepsy. ( Arbabi, E; Atyabi, F; Dinarvand, R; Hassanzadeh, P, 2017) |
| " In the present study, the effect of tianeptine, an antidepressant, was evaluated against pentylenetetrazole (PTZ)-induced seizures, cognitive impairment and oxidative stress in rats." | 7.83 | Anticonvulsant activity of the antidepressant drug, tianeptine, against pentylenetetrazole-induced seizures mitigates cognitive impairment in rats. ( Gupta, YK; Prabhakar, P; Reeta, Kh, 2016) |
| "Evidence suggests that improving brain inflammation can inhibit the epileptogenesis process and help the emergence of new drugs for the treatment of epilepsy." | 5.72 | Thiamine alleviates cognitive impairment and epileptogenesis by relieving brain inflammation in PTZ-induced kindling rat model. ( Akkaya, R; Filiz, AK; Karabulut, S, 2022) |
| "Epilepsy is a chronic neurological disorder which affects 65 million worldwide population and characterized by recurrent seizure in epileptic patients." | 5.48 | The anti-epileptogenic and cognition enhancing effect of novel 1-[4-(4-benzo [1, 3] dioxol-5-ylmethyl-piperazin-1-yl)-phenyl]-3-phenyl-urea (BPPU) in pentylenetetrazole induced chronic rat model of epilepsy. ( Kumari, S; Mishra, CB; Siraj, F; Tiwari, AK; Tiwari, M; Yadav, R, 2018) |
| "Epilepsy is fourth most common neurological disorders associated with depression and cognitive deficits." | 5.46 | Agmatine for combined treatment of epilepsy, depression and cognitive impairment in chronic epileptic animals. ( Bagga, N; Gawande, DY; Goel, RK; Kaur, A; Kaur, N; Singh, T, 2017) |
| "Lamotrigine (LTG) is a broad-spectrum antiepileptic drug that is widely used in clinic." | 5.46 | Effect of lamotrigine on epilepsy-induced cognitive impairment and hippocampal neuronal apoptosis in pentylenetetrazole-kindled animal model. ( Dong, RF; Tian, S; Wang, WP; Zhang, B; Zhang, C; Zhang, JW, 2017) |
| "To investigate the effects of different doses of esculetin on epileptiform activity, behavioral seizures, memory impairment, and cortical and hippocampal NF-κB, as a mediator of pro-inflammatory gene induction, and pro-inflammatory cytokines in penicillin- and pentylenetetrazole(PTZ)-induced seizure models in rats." | 4.31 | Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats. ( Ankarali, H; Baranoglu Kilinc, Y; Danis, A; Hanci, F; Kilinc, E; Torun, IE, 2023) |
| " The present study was designed to explore the effect of fisetin in the pentylenetetrazole (PTZ) kindling-induced cognitive dysfunction in mice." | 4.31 | Fisetin provides neuroprotection in pentylenetetrazole-induced cognition impairment by upregulating CREB/BDNF. ( Dahalia, M; Khatoon, S; Samim, M, 2023) |
| " In the pharmacodynamic interaction study, seizures were induced using pentylenetetrazole (PTZ) (60 mg/kg, i." | 4.02 | Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats. ( Agarwal, A; Arora, R; Ganeshan N, S; Gupta, YK; Kaleekal, T; Kumar, R; Sarangi, SC, 2021) |
| "This study was conducted to evaluate the effect of embelin (EMB) on various epileptic models and related brain inflammation." | 4.02 | Embelin ameliorates cognitive dysfunction and progression of kindling in pentylenetetrazol-induced kindling in mice by attenuating brain inflammation. ( Agarwal, NB; Hoda, U; Jain, GK; Jain, S; Samim, M, 2021) |
| " The present study was designed to evaluate the effect of arbutin supplementation on seizures behavior, memory performance, glial activation, release of inflammatory factors and neuroprotection in pentylenetetrazole-induced kindling model." | 3.91 | Arbutin attenuates cognitive impairment and inflammatory response in pentylenetetrazol-induced kindling model of epilepsy. ( Ahmadian, SR; Ghasemi-Kasman, M; Pouramir, M; Sadeghi, F, 2019) |
| " For in-vivo study, seizures were induced in Wistar rats (200-225g) by pentylenetetrazole (PTZ) and maximal-electroshock." | 3.88 | Protective effect of Terminalia chebula against seizures, seizure-induced cognitive impairment and oxidative stress in experimental models of seizures in rats. ( Agarwal, A; Arora, R; Gupta, YK; Kumar, R, 2018) |
| " Ferulic acid at doses of 75 and 100mg/kg significantly reduced the seizure score, number of myoclonic jerks, cognitive decline and oxidative stress." | 3.85 | Ferulic acid exhibits antiepileptogenic effect and prevents oxidative stress and cognitive impairment in the kindling model of epilepsy. ( Arbabi, E; Atyabi, F; Dinarvand, R; Hassanzadeh, P, 2017) |
| " In the present study, the effect of tianeptine, an antidepressant, was evaluated against pentylenetetrazole (PTZ)-induced seizures, cognitive impairment and oxidative stress in rats." | 3.83 | Anticonvulsant activity of the antidepressant drug, tianeptine, against pentylenetetrazole-induced seizures mitigates cognitive impairment in rats. ( Gupta, YK; Prabhakar, P; Reeta, Kh, 2016) |
| "Epilepsy is a common neurological disorder affecting more than 70 million people worldwide." | 1.91 | ( Gao, Y; Jiang, X; Liang, X; Liu, W; Lu, H; Wang, N; Xing, B; Xu, X; Zhao, Q; Zhou, L, 2023) |
| "Evidence suggests that improving brain inflammation can inhibit the epileptogenesis process and help the emergence of new drugs for the treatment of epilepsy." | 1.72 | Thiamine alleviates cognitive impairment and epileptogenesis by relieving brain inflammation in PTZ-induced kindling rat model. ( Akkaya, R; Filiz, AK; Karabulut, S, 2022) |
| "Epilepsy is a chronic brain disease affecting millions of people worldwide." | 1.62 | Environmental enrichment alters neurobehavioral development following maternal immune activation in mice offspring with epilepsy. ( Mosaferi, B; Najdi, N; Salari, AA; Zeraati, M, 2021) |
| "Seizures were induced in rats (postnatal day 10) by 5% O2 exposure for 15 min." | 1.62 | FTY720 administration following hypoxia-induced neonatal seizure reverse cognitive impairments and severity of seizures in male and female adult rats: The role of inflammation. ( Farbood, Y; Ghafouri, S; Najafian, SA; Sarkaki, A, 2021) |
| "Epilepsy is one of the most common neurological diseases." | 1.56 | COX-2-PGE ( Dong, J; Gan, G; Hu, S; Li, X; Yang, J; Yao, Y; Zhang, A; Zhang, C; Zhengxie, J; Zhu, X, 2020) |
| "Acute seizures were induced in zebrafish using pentylenetetrazol (PTZ) and cognitive function was assessed using the T-maze test of learning and memory." | 1.51 | Effect of newer anti-epileptic drugs (AEDs) on the cognitive status in pentylenetetrazol induced seizures in a zebrafish model. ( Choo, BKM; Johan Arief, MFB; Kumari, Y; Kundap, UP; Othman, I; Shaikh, MF; Wong, CP; Yap, JL, 2019) |
| "The susceptibility to seizures was evaluated by seizure frequency and duration." | 1.51 | Chronic exercise buffers the cognitive dysfunction and decreases the susceptibility to seizures in PTZ-treated rats. ( Chen, W; Cui, Y; Lin, XY; Wang, L, 2019) |
| "Epilepsy is a complicated neurological disorder that occurs worldwide and features several kinds of comorbidities in addition to recurrent seizures." | 1.48 | Adenosine A1 Receptors Play an Important Protective Role Against Cognitive Impairment and Long-Term Potentiation Inhibition in a Pentylenetetrazol Mouse Model of Epilepsy. ( Guo, Y; Hu, Q; Kang, H; Lian, L; Liu, X; Xu, F; Zhang, N; Zhou, Q; Zhu, S, 2018) |
| "Quercetin is a major flavonoid in various plants." | 1.48 | Therapeutic evaluation of solid lipid nanoparticle of quercetin in pentylenetetrazole induced cognitive impairment of zebrafish. ( Muthuraman, A; Rishitha, N, 2018) |
| "Epilepsy is a chronic neurological disorder which affects 65 million worldwide population and characterized by recurrent seizure in epileptic patients." | 1.48 | The anti-epileptogenic and cognition enhancing effect of novel 1-[4-(4-benzo [1, 3] dioxol-5-ylmethyl-piperazin-1-yl)-phenyl]-3-phenyl-urea (BPPU) in pentylenetetrazole induced chronic rat model of epilepsy. ( Kumari, S; Mishra, CB; Siraj, F; Tiwari, AK; Tiwari, M; Yadav, R, 2018) |
| "Epilepsy is fourth most common neurological disorders associated with depression and cognitive deficits." | 1.46 | Agmatine for combined treatment of epilepsy, depression and cognitive impairment in chronic epileptic animals. ( Bagga, N; Gawande, DY; Goel, RK; Kaur, A; Kaur, N; Singh, T, 2017) |
| "Lamotrigine (LTG) is a broad-spectrum antiepileptic drug that is widely used in clinic." | 1.46 | Effect of lamotrigine on epilepsy-induced cognitive impairment and hippocampal neuronal apoptosis in pentylenetetrazole-kindled animal model. ( Dong, RF; Tian, S; Wang, WP; Zhang, B; Zhang, C; Zhang, JW, 2017) |
| "Crocin is a pharmacologically active carotenoid pigment mainly present in the stigmas of Crocus sativus L." | 1.46 | Crocin Attenuates Kindling Development and Associated Cognitive Impairments in Mice via Inhibiting Reactive Oxygen Species-Mediated NF-κB Activation. ( Mazumder, AG; Patial, V; Sharma, P; Singh, D, 2017) |
| "Cognitive dysfunction is commonly observed in epileptic patients." | 1.46 | A potential mechanism for the ameliorative effect of thymoquinone on pentylenetetrazole-induced kindling and cognitive impairments in mice. ( Abdel-Rahman, MS; Abdel-Wahab, BA; Abdel-Zaher, AO; Farghaly, HSM; Farrag, MMY, 2017) |
| "Pretreatment with LU suppressed seizure induction, duration, and severity following PTZ injection, reversed cognitive impairment, reduced neuronal and oxidative stress damage, and increased phosphoactivation of PKA and CREB as well as BDNF expression." | 1.43 | Luteolin rescues pentylenetetrazole-induced cognitive impairment in epileptic rats by reducing oxidative stress and activating PKA/CREB/BDNF signaling. ( Chang, YN; Fu, T; Liu, JQ; Qu, ZZ; Wang, WP; Zhen, JL, 2016) |
| "Seizures were induced by a daily intraperitoneal (i." | 1.40 | Effects of grape seed proanthocyanidin extract on pentylenetetrazole-induced kindling and associated cognitive impairment in rats. ( Fang, H; Fu, L; Qu, Z; Wang, H; Wang, W; Wu, Y; Zang, H; Zhen, J, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 17 (50.00) | 24.3611 |
| 2020's | 17 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, L | 5 |
| Ding, J | 1 |
| Zhu, C | 1 |
| Guo, B | 1 |
| Yang, W | 1 |
| He, W | 1 |
| Li, X | 2 |
| Wang, Y | 1 |
| Li, W | 1 |
| Wang, F | 1 |
| Sun, T | 1 |
| Siddiqui, MA | 1 |
| Akhter, J | 1 |
| Junaid Bashir, D | 1 |
| Manzoor, S | 1 |
| Rastogi, S | 1 |
| Arora, I | 1 |
| Aggarwal, NB | 1 |
| Samim, M | 3 |
| Zhou, L | 1 |
| Gao, Y | 1 |
| Lu, H | 1 |
| Liu, W | 1 |
| Xu, X | 1 |
| Xing, B | 1 |
| Liang, X | 1 |
| Wang, N | 1 |
| Jiang, X | 1 |
| Zhao, Q | 1 |
| Karabulut, S | 1 |
| Filiz, AK | 1 |
| Akkaya, R | 1 |
| Zhuang, XF | 3 |
| Liu, YX | 3 |
| Yang, ZH | 3 |
| Gao, Q | 3 |
| Ju, C | 3 |
| Wang, K | 3 |
| Danis, A | 1 |
| Baranoglu Kilinc, Y | 1 |
| Torun, IE | 1 |
| Hanci, F | 1 |
| Kilinc, E | 1 |
| Ankarali, H | 1 |
| Khatoon, S | 1 |
| Dahalia, M | 1 |
| Chen, W | 2 |
| Man, X | 1 |
| Zhang, Y | 1 |
| Yao, G | 1 |
| Chen, J | 1 |
| Zheng, Q | 1 |
| Zhu, T | 1 |
| Hu, H | 1 |
| Zhao, Y | 1 |
| Ying, Y | 1 |
| Luo, X | 1 |
| Ling, Y | 1 |
| Chen, Z | 1 |
| Ji, H | 1 |
| Jiang, P | 1 |
| Zhu, X | 1 |
| Yao, Y | 1 |
| Yang, J | 1 |
| Zhengxie, J | 1 |
| Hu, S | 1 |
| Zhang, A | 1 |
| Dong, J | 1 |
| Zhang, C | 2 |
| Gan, G | 1 |
| Mishra, P | 1 |
| Mittal, AK | 1 |
| Rajput, SK | 1 |
| Sinha, JK | 1 |
| Zeraati, M | 1 |
| Najdi, N | 1 |
| Mosaferi, B | 1 |
| Salari, AA | 1 |
| Kumar, R | 3 |
| Arora, R | 2 |
| Sarangi, SC | 1 |
| Ganeshan N, S | 1 |
| Agarwal, A | 2 |
| Kaleekal, T | 1 |
| Gupta, YK | 3 |
| Najafian, SA | 1 |
| Farbood, Y | 1 |
| Sarkaki, A | 1 |
| Ghafouri, S | 1 |
| Hoda, U | 1 |
| Jain, S | 1 |
| Jain, GK | 1 |
| Agarwal, NB | 1 |
| Kavaye Kandeda, A | 1 |
| Okomolo Moto, FC | 1 |
| Mbomo Ayissi, RE | 1 |
| Omam Omam, JP | 1 |
| Ojong, L | 1 |
| Ngo Bum, E | 1 |
| Singh, T | 2 |
| Mishra, A | 1 |
| Goel, RK | 2 |
| Zhou, Q | 1 |
| Zhu, S | 1 |
| Guo, Y | 1 |
| Lian, L | 1 |
| Hu, Q | 1 |
| Liu, X | 1 |
| Xu, F | 1 |
| Zhang, N | 1 |
| Kang, H | 1 |
| Bagga, N | 1 |
| Kaur, A | 1 |
| Kaur, N | 1 |
| Gawande, DY | 1 |
| Rishitha, N | 1 |
| Muthuraman, A | 1 |
| Mishra, CB | 1 |
| Kumari, S | 2 |
| Siraj, F | 1 |
| Yadav, R | 1 |
| Tiwari, AK | 1 |
| Tiwari, M | 1 |
| Iqubal, A | 1 |
| Sharma, S | 1 |
| Sharma, K | 1 |
| Bhavsar, A | 1 |
| Hussain, I | 1 |
| Iqubal, MK | 1 |
| Ahmadian, SR | 1 |
| Ghasemi-Kasman, M | 1 |
| Pouramir, M | 1 |
| Sadeghi, F | 1 |
| Choo, BKM | 1 |
| Kundap, UP | 1 |
| Johan Arief, MFB | 1 |
| Kumari, Y | 1 |
| Yap, JL | 1 |
| Wong, CP | 1 |
| Othman, I | 1 |
| Shaikh, MF | 1 |
| Lin, XY | 1 |
| Cui, Y | 1 |
| Zhen, J | 1 |
| Qu, Z | 1 |
| Fang, H | 1 |
| Fu, L | 1 |
| Wu, Y | 1 |
| Wang, H | 1 |
| Zang, H | 1 |
| Wang, W | 1 |
| Zhen, JL | 1 |
| Chang, YN | 1 |
| Qu, ZZ | 1 |
| Fu, T | 1 |
| Liu, JQ | 1 |
| Wang, WP | 2 |
| Hassanzadeh, P | 1 |
| Arbabi, E | 1 |
| Atyabi, F | 1 |
| Dinarvand, R | 1 |
| Reeta, Kh | 1 |
| Prabhakar, P | 1 |
| Bhardwaj, M | 1 |
| Kumar, A | 1 |
| Zhang, B | 1 |
| Zhang, JW | 1 |
| Dong, RF | 1 |
| Tian, S | 1 |
| Mazumder, AG | 1 |
| Sharma, P | 1 |
| Patial, V | 1 |
| Singh, D | 1 |
| Abdel-Zaher, AO | 1 |
| Farghaly, HSM | 1 |
| Farrag, MMY | 1 |
| Abdel-Rahman, MS | 1 |
| Abdel-Wahab, BA | 1 |
1 review available for pentylenetetrazole and Cognitive Decline
| Article | Year |
|---|---|
PTZ kindling model for epileptogenesis, refractory epilepsy, and associated comorbidities: relevance and reliability.
Topics: Animals; Anticonvulsants; Cognitive Dysfunction; Depression; Disease Models, Animal; Drug Resistance | 2021 |
33 other studies available for pentylenetetrazole and Cognitive Decline
| Article | Year |
|---|---|
Semaglutide attenuates seizure severity and ameliorates cognitive dysfunction by blocking the NLR family pyrin domain containing 3 inflammasome in pentylenetetrazole‑kindled mice.
Topics: Animals; Apoptosis; Cell Line; Cognitive Dysfunction; Cytokines; Disease Models, Animal; Epilepsy; G | 2021 |
Resveratrol loaded nanoparticles attenuate cognitive impairment and inflammatory markers in PTZ-induced kindled mice.
Topics: Animals; Antioxidants; Cognitive Dysfunction; Collagen; Disease Models, Animal; Epilepsy; Glutathion | 2021 |
Topics: Alzheimer Disease; Animals; Anticonvulsants; Cognitive Dysfunction; Disease Models, Animal; Epilepsy | 2023 |
Thiamine alleviates cognitive impairment and epileptogenesis by relieving brain inflammation in PTZ-induced kindling rat model.
Topics: Animals; Cognitive Dysfunction; Cyclooxygenase 2; Encephalitis; Epilepsy; Kindling, Neurologic; Male | 2022 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats.
Topics: Animals; Anticonvulsants; Cognitive Dysfunction; Cytokines; Diazepam; Disease Models, Animal; Epilep | 2023 |
Fisetin provides neuroprotection in pentylenetetrazole-induced cognition impairment by upregulating CREB/BDNF.
Topics: Acetylcholinesterase; Animals; Brain-Derived Neurotrophic Factor; Cognition; Cognitive Dysfunction; | 2023 |
Medial prefrontal cortex oxytocin mitigates epilepsy and cognitive impairments induced by traumatic brain injury through reducing neuroinflammation in mice.
Topics: Animals; Anticonvulsants; Brain Injuries, Traumatic; Cognitive Dysfunction; Disease Models, Animal; | 2023 |
TRPM2 ion channel is involved in the aggravation of cognitive impairment and down regulation of epilepsy threshold in pentylenetetrazole-induced kindling mice.
Topics: Animals; Apoptosis; Astrocytes; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Hippocampus | 2020 |
COX-2-PGE
Topics: Animals; Cognitive Dysfunction; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Epilepsy; Hi | 2020 |
Cognition and memory impairment attenuation via reduction of oxidative stress in acute and chronic mice models of epilepsy using antiepileptogenic Nux vomica.
Topics: Acute Disease; Animals; Anticonvulsants; Antioxidants; Behavior, Animal; Brain; Chronic Disease; Cog | 2021 |
Environmental enrichment alters neurobehavioral development following maternal immune activation in mice offspring with epilepsy.
Topics: Animals; Anxiety; Behavior, Animal; Cognitive Dysfunction; Convulsants; Disease Models, Animal; Dise | 2021 |
Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats.
Topics: Adjuvants, Pharmaceutic; Animals; Anticonvulsants; Behavior, Animal; Centella; Cognitive Dysfunction | 2021 |
FTY720 administration following hypoxia-induced neonatal seizure reverse cognitive impairments and severity of seizures in male and female adult rats: The role of inflammation.
Topics: Aging; Animals; Animals, Newborn; Cognitive Dysfunction; Epilepsy; Female; Fingolimod Hydrochloride; | 2021 |
Embelin ameliorates cognitive dysfunction and progression of kindling in pentylenetetrazol-induced kindling in mice by attenuating brain inflammation.
Topics: Animals; Benzoquinones; Cognitive Dysfunction; Encephalitis; Kindling, Neurologic; Male; Mice; Penty | 2021 |
Pergularia daemia hydro-ethanolic extract protects against pentylenetetrazole kindling-induced seizures, oxidative stress, and neuroinflammation in mice.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Antioxidants; Apocynaceae; Cameroon; Cognitive D | 2021 |
Adenosine A1 Receptors Play an Important Protective Role Against Cognitive Impairment and Long-Term Potentiation Inhibition in a Pentylenetetrazol Mouse Model of Epilepsy.
Topics: Animals; Caspase 3; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, | 2018 |
Agmatine for combined treatment of epilepsy, depression and cognitive impairment in chronic epileptic animals.
Topics: Agmatine; Animals; Cognitive Dysfunction; Depression; Epilepsy; Male; Mice; Pentylenetetrazole | 2017 |
Protective effect of Terminalia chebula against seizures, seizure-induced cognitive impairment and oxidative stress in experimental models of seizures in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzothiazoles; Biphenyl Compounds; Cognitive Dysfunctio | 2018 |
Therapeutic evaluation of solid lipid nanoparticle of quercetin in pentylenetetrazole induced cognitive impairment of zebrafish.
Topics: Animals; Cognitive Dysfunction; Drug Carriers; Lipids; Male; Nanoparticles; Particle Size; Pentylene | 2018 |
The anti-epileptogenic and cognition enhancing effect of novel 1-[4-(4-benzo [1, 3] dioxol-5-ylmethyl-piperazin-1-yl)-phenyl]-3-phenyl-urea (BPPU) in pentylenetetrazole induced chronic rat model of epilepsy.
Topics: Animals; Cerebral Cortex; Chronic Disease; Cognition; Cognitive Dysfunction; Disease Models, Animal; | 2018 |
Intranasally administered pitavastatin ameliorates pentylenetetrazol-induced neuroinflammation, oxidative stress and cognitive dysfunction.
Topics: Administration, Intranasal; Animals; Behavior, Animal; Cognitive Dysfunction; Convulsants; Hydroxyme | 2018 |
Arbutin attenuates cognitive impairment and inflammatory response in pentylenetetrazol-induced kindling model of epilepsy.
Topics: Animals; Antigens, Nuclear; Arbutin; Astrocytes; Cognitive Dysfunction; Cytokines; Disease Models, A | 2019 |
Effect of newer anti-epileptic drugs (AEDs) on the cognitive status in pentylenetetrazol induced seizures in a zebrafish model.
Topics: Acetylcholine; Animals; Anticonvulsants; Brain; Brain-Derived Neurotrophic Factor; Cognitive Dysfunc | 2019 |
Chronic exercise buffers the cognitive dysfunction and decreases the susceptibility to seizures in PTZ-treated rats.
Topics: Animals; Cognitive Dysfunction; Disease Models, Animal; Pentylenetetrazole; Physical Conditioning, A | 2019 |
Effects of grape seed proanthocyanidin extract on pentylenetetrazole-induced kindling and associated cognitive impairment in rats.
Topics: Animals; Antioxidants; Cognitive Dysfunction; Free Radicals; Grape Seed Extract; Humans; Kindling, N | 2014 |
Luteolin rescues pentylenetetrazole-induced cognitive impairment in epileptic rats by reducing oxidative stress and activating PKA/CREB/BDNF signaling.
Topics: Animals; Anticonvulsants; Brain; Brain-Derived Neurotrophic Factor; Cognition; Cognitive Dysfunction | 2016 |
Ferulic acid exhibits antiepileptogenic effect and prevents oxidative stress and cognitive impairment in the kindling model of epilepsy.
Topics: Animals; Anticonvulsants; Antioxidants; Avoidance Learning; Cognitive Dysfunction; Coumaric Acids; D | 2017 |
Anticonvulsant activity of the antidepressant drug, tianeptine, against pentylenetetrazole-induced seizures mitigates cognitive impairment in rats.
Topics: Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Avoidance Learning; Behavior, Animal; Co | 2016 |
Neuroprotective mechanism of Coenzyme Q10 (CoQ10) against PTZ induced kindling and associated cognitive dysfunction: Possible role of microglia inhibition.
Topics: Animals; Cerebral Cortex; Cognitive Dysfunction; Dose-Response Relationship, Drug; Hippocampus; Infl | 2016 |
Effect of lamotrigine on epilepsy-induced cognitive impairment and hippocampal neuronal apoptosis in pentylenetetrazole-kindled animal model.
Topics: Animals; Anticonvulsants; Apoptosis; CA1 Region, Hippocampal; Cognitive Dysfunction; Epilepsy; Femal | 2017 |
Crocin Attenuates Kindling Development and Associated Cognitive Impairments in Mice via Inhibiting Reactive Oxygen Species-Mediated NF-κB Activation.
Topics: Animals; Carotenoids; Cognition Disorders; Cognitive Dysfunction; Crocus; Disease Models, Animal; Do | 2017 |
A potential mechanism for the ameliorative effect of thymoquinone on pentylenetetrazole-induced kindling and cognitive impairments in mice.
Topics: Animals; Avoidance Learning; Behavior, Animal; Benzoquinones; Brain; Cognitive Dysfunction; Glutathi | 2017 |