pentylenetetrazole has been researched along with Cognition Disorders in 29 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.
| Excerpt | Relevance | Reference |
|---|---|---|
| " All rats except those from the sham group were treated with PTZ to establish temporal lobe epilepsy (TLE) models, whereas the P38 MAPK inhibitor SB 203580 was given to the inhibitor group." | 7.85 | P38 MAPK pathway mediates cognitive damage in pentylenetetrazole-induced epilepsy via apoptosis cascade. ( Huang, Q; Huang, Y; Liao, Y; Liu, X; Ma, M; Wei, X; Wu, Y, 2017) |
| " In the present study, we examined its effect on convulsions, oxidative stress and cognitive impairment in pentylenetetrazole (PTZ) induced seizures in rats." | 7.81 | Panchagavya Ghrita, an Ayurvedic formulation attenuates seizures, cognitive impairment and oxidative stress in pentylenetetrazole induced seizures in rats. ( Gupta, YK; Joshi, R; Reeta, KH; Sharma, SK; Tripathi, M, 2015) |
| " Hence, this study was conducted to evaluate the effect of curcumin against seizures, cognitive impairment and oxidative stress in pentylenetetrazole-induced kindling in rats." | 7.76 | Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model. ( Gupta, P; Gupta, YK; Mehla, J; Reeta, KH, 2010) |
| "Levetiracetam (LEV) is a unique, effective, relatively safe antiepileptic drug that preferentially interacts with synaptic vesicle protein 2A (SV2A)." | 5.42 | Omega 3 polyunsaturated fatty acids enhance the protective effect of levetiracetam against seizures, cognitive impairment and hippocampal oxidative DNA damage in young kindled rats. ( Abdel-Wahab, BA; Habeeb, SM; Khateeb, MM; Shaikh, IA, 2015) |
| "Naringin is a bioflavonoid present in the grapefruit." | 5.40 | Naringin ameliorates pentylenetetrazol-induced seizures and associated oxidative stress, inflammation, and cognitive impairment in rats: possible mechanisms of neuroprotection. ( Arya, DS; Bhatia, J; Chaudhry, U; Golechha, M; Saluja, D; Sarangal, V, 2014) |
| "Many of the neurochemical changes associated with aging brain, particularly lower choline acetyltransferase and higher monoamine oxidase, occur with greater severity in senile dementia, Alzheimer's type (SDAT)." | 4.76 | Chemotherapy of cognitive disorders in geriatric subjects. ( Gershon, S; Goodnick, P, 1984) |
| " In this study, the effect of antidepressant sertraline (SRT) in combination with AEDs sodium valproate (SV) and levetiracetam (LEV) on seizures, cognitive impairment and oxidative stress in rats was evaluated." | 4.02 | Response to sertraline and antiepileptic drugs in pentylenetetrazole kindling in rats. ( Hussain, M; Katyal, J; Rashid, H, 2021) |
| " All rats except those from the sham group were treated with PTZ to establish temporal lobe epilepsy (TLE) models, whereas the P38 MAPK inhibitor SB 203580 was given to the inhibitor group." | 3.85 | P38 MAPK pathway mediates cognitive damage in pentylenetetrazole-induced epilepsy via apoptosis cascade. ( Huang, Q; Huang, Y; Liao, Y; Liu, X; Ma, M; Wei, X; Wu, Y, 2017) |
| " In the present study, we examined its effect on convulsions, oxidative stress and cognitive impairment in pentylenetetrazole (PTZ) induced seizures in rats." | 3.81 | Panchagavya Ghrita, an Ayurvedic formulation attenuates seizures, cognitive impairment and oxidative stress in pentylenetetrazole induced seizures in rats. ( Gupta, YK; Joshi, R; Reeta, KH; Sharma, SK; Tripathi, M, 2015) |
| " officinalis (HAEEO) administered intraperitoneally to rats was evaluated on pentylenetetrazole (PTZ) induced seizures, cognitive deficit and oxidative stress markers viz malondialdehyde (MDA) and glutathione." | 3.76 | Hydroalcoholic extract of Emblica officinalis Gaertn. affords protection against PTZ-induced seizures, oxidative stress and cognitive impairment in rats. ( Arya, DS; Bhatia, J; Golechha, M, 2010) |
| " Hence, this study was conducted to evaluate the effect of curcumin against seizures, cognitive impairment and oxidative stress in pentylenetetrazole-induced kindling in rats." | 3.76 | Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model. ( Gupta, P; Gupta, YK; Mehla, J; Reeta, KH, 2010) |
| "On the basis of epileptic model induced by pentylenetetrazol (PTZ), cognitive impairment model was induced by kindling epilepsy with PTZ everyday, which were then di-vided into the model-1 group, the CZD-1 group, the nimodipine-1 group, and those by injecting large dosage phenytoin sodium were divided into the model-2 group, the CZD-2 group and the nimodipine-2 group." | 3.74 | [Influence of repeated seizures and large dosage anti-epileptic drug on phosphorylated cAMP response element binding protein in rat's hippocampus and effect of Caoguo Zhimu Decoction]. ( He, J; Ma, SL, 2007) |
| "Crocin treatment at 5, 10 and 20 mg/kg p." | 1.46 | Crocin Attenuates Kindling Development and Associated Cognitive Impairments in Mice via Inhibiting Reactive Oxygen Species-Mediated NF-κB Activation. ( Mazumder, AG; Patial, V; Sharma, P; Singh, D, 2017) |
| "Treatment with phenytoin per se and along with the flavonoid rich fraction showed significant reduction in seizure severity score as compared to vehicle control." | 1.43 | Protective effect on phenytoin-induced cognition deficit in pentylenetetrazol kindled mice: A repertoire of Glycyrrhiza glabra flavonoid antioxidants. ( Goel, RK; Singh, D; Singh, P, 2016) |
| "apodanthera showed dose-dependent antiseizure effects." | 1.42 | Effects of a lyophilized aqueous extract of Feretia apodanthera Del. (Rubiaceae) on pentylenetetrazole-induced kindling, oxidative stress, and cognitive impairment in mice. ( Ayissi, ER; Kandeda, AK; Kouemou, N; Moto, FC; Ngo Bum, E; Ngoupaye, GT; Njapdounke, JS; Nkantchoua, GC; Omam, JP; Pahaye, D; Pale, S; Taiwe, GS, 2015) |
| "Levetiracetam (LEV) is a unique, effective, relatively safe antiepileptic drug that preferentially interacts with synaptic vesicle protein 2A (SV2A)." | 1.42 | Omega 3 polyunsaturated fatty acids enhance the protective effect of levetiracetam against seizures, cognitive impairment and hippocampal oxidative DNA damage in young kindled rats. ( Abdel-Wahab, BA; Habeeb, SM; Khateeb, MM; Shaikh, IA, 2015) |
| "Latency and probability of PTZ-induced seizures were shorter and higher respectively, in hyperthermia-treated animals compared to controls." | 1.40 | Cognitive performance and convulsion risk after experimentally-induced febrile-seizures in rat. ( Abdeen, Z; Al Shawaaf, F; Al-Ansari, S; Alsaffar, Y; Hassan, Z; Kamal, A; Mandeel, M; Rajab, E, 2014) |
| "Naringin is a bioflavonoid present in the grapefruit." | 1.40 | Naringin ameliorates pentylenetetrazol-induced seizures and associated oxidative stress, inflammation, and cognitive impairment in rats: possible mechanisms of neuroprotection. ( Arya, DS; Bhatia, J; Chaudhry, U; Golechha, M; Saluja, D; Sarangal, V, 2014) |
| " Chronic administration of a subconvulsive dose of PTZ resulted in an increase in convulsive activity culminating in generalized clonic-tonic seizures, as revealed by a progressive increase in seizure score as well as alteration in antioxidant enzyme levels (lipid peroxidation, nitrite, glutathione, super oxide dismutase, and catalase) and mitochondrial complex (I, II, and IV) activities, whereas chronic treatment with hesperidin (200 mg/kg) significantly attenuated these behavioral, biochemical, and mitochondrial alterations." | 1.39 | Possible nitric oxide mechanism in the protective effect of hesperidin against pentylenetetrazole (PTZ)-induced kindling and associated cognitive dysfunction in mice. ( Kumar, A; Lalitha, S; Mishra, J, 2013) |
| "A clonic-tonic seizure episode was induced by a single i." | 1.39 | A single pentylenetetrazole-induced clonic-tonic seizure episode is accompanied by a slowly developing cognitive decline in rats. ( Aniol, VA; Guekht, AB; Gulyaeva, NV; Ivanova-Dyatlova, AY; Keren, O; Sarne, Y, 2013) |
| "pyrethrum (HEAP) root against seizures, seizure-induced oxidative stress and cognitive impairment in experimental models of seizures." | 1.38 | Root extract of Anacyclus pyrethrum ameliorates seizures, seizure-induced oxidative stress and cognitive impairment in experimental animals. ( Gupta, YK; Joshi, S; Mehla, J; Pahuja, M; Reeta, KH, 2012) |
| " To conclude, long term administration of topiramate impairs cognitive functions during experimental epilepsy while lamotrigine and oxcarbazepine are safer." | 1.37 | Effect of lamotrigine, oxcarbazepine and topiramate on cognitive functions and oxidative stress in PTZ-kindled mice. ( Agarwal, NB; Agarwal, NK; Mediratta, PK; Sharma, KK, 2011) |
| "Lamotrigine treatment had no effect on oxidative stress parameters alone, while it significantly decreased oxidative stress in the pentylenetetrazole-kindled group as compared to the pentylenetetrazole-kindled carbamazepine-treated group." | 1.36 | Effect of carbamazepine and lamotrigine on cognitive function and oxidative stress in brain during chemical epileptogenesis in rats. ( Arora, T; Banerjee, BD; Garg, GR; Mediratta, PK; Mehta, AK; Sharma, AK; Sharma, KK, 2010) |
| "Seizures were terminated 30min later by ketamine (50mg/kg, i." | 1.32 | NMDA-induced seizures in developing rats cause long-term learning impairment and increased seizure susceptibility. ( Sasaki-Adams, DM; Stafstrom, CE, 2003) |
| "All rats given PTZ developed recurrent seizures." | 1.31 | Maternal deprivation stress exacerbates cognitive deficits in immature rats with recurrent seizures. ( Holmes, GL; Huang, LT; Hung, PL; Lai, MC; Liou, CW; Wang, CL; Wang, TJ; Yang, CH; Yang, SN, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.90) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (17.24) | 29.6817 |
| 2010's | 20 (68.97) | 24.3611 |
| 2020's | 2 (6.90) | 2.80 |
| Authors | Studies |
|---|---|
| Hussain, M | 1 |
| Rashid, H | 1 |
| Katyal, J | 1 |
| Safar, MM | 1 |
| Shahin, NN | 1 |
| Mohamed, AF | 1 |
| Abdelkader, NF | 1 |
| Huang, Q | 1 |
| Liu, X | 1 |
| Wu, Y | 1 |
| Liao, Y | 1 |
| Huang, Y | 1 |
| Wei, X | 1 |
| Ma, M | 1 |
| Kumar, A | 1 |
| Lalitha, S | 1 |
| Mishra, J | 1 |
| Rajab, E | 1 |
| Abdeen, Z | 1 |
| Hassan, Z | 1 |
| Alsaffar, Y | 1 |
| Mandeel, M | 1 |
| Al Shawaaf, F | 1 |
| Al-Ansari, S | 1 |
| Kamal, A | 1 |
| Golechha, M | 2 |
| Sarangal, V | 1 |
| Bhatia, J | 2 |
| Chaudhry, U | 1 |
| Saluja, D | 1 |
| Arya, DS | 2 |
| Taiwe, GS | 1 |
| Moto, FC | 1 |
| Ayissi, ER | 1 |
| Ngoupaye, GT | 1 |
| Njapdounke, JS | 1 |
| Nkantchoua, GC | 1 |
| Kouemou, N | 1 |
| Omam, JP | 1 |
| Kandeda, AK | 1 |
| Pale, S | 1 |
| Pahaye, D | 1 |
| Ngo Bum, E | 1 |
| Soni, N | 1 |
| Koushal, P | 1 |
| Reddy, BV | 1 |
| Deshmukh, R | 1 |
| Kumar, P | 1 |
| Abdel-Wahab, BA | 1 |
| Shaikh, IA | 1 |
| Khateeb, MM | 1 |
| Habeeb, SM | 1 |
| Singh, P | 1 |
| Singh, D | 2 |
| Goel, RK | 1 |
| Ma, L | 1 |
| Yang, F | 1 |
| Zhao, R | 1 |
| Li, L | 1 |
| Kang, X | 1 |
| Xiao, L | 1 |
| Jiang, W | 1 |
| Joshi, R | 1 |
| Reeta, KH | 3 |
| Sharma, SK | 1 |
| Tripathi, M | 1 |
| Gupta, YK | 3 |
| Mazumder, AG | 1 |
| Sharma, P | 1 |
| Patial, V | 1 |
| Arora, T | 1 |
| Mehta, AK | 1 |
| Sharma, KK | 2 |
| Mediratta, PK | 2 |
| Banerjee, BD | 1 |
| Garg, GR | 1 |
| Sharma, AK | 1 |
| Mehla, J | 2 |
| Gupta, P | 1 |
| Agarwal, NB | 1 |
| Agarwal, NK | 1 |
| Assaf, F | 1 |
| Fishbein, M | 1 |
| Gafni, M | 1 |
| Keren, O | 2 |
| Sarne, Y | 2 |
| Pahuja, M | 1 |
| Joshi, S | 1 |
| Wilhelm, EA | 1 |
| Souza, AC | 1 |
| Gai, BM | 1 |
| Chagas, PM | 1 |
| Roehrs, JA | 1 |
| Nogueira, CW | 1 |
| Xie, T | 1 |
| Wang, WP | 1 |
| Jia, LJ | 1 |
| Mao, ZF | 1 |
| Qu, ZZ | 1 |
| Luan, SQ | 1 |
| Kan, MC | 1 |
| Aniol, VA | 1 |
| Ivanova-Dyatlova, AY | 1 |
| Guekht, AB | 1 |
| Gulyaeva, NV | 1 |
| Huang, LT | 1 |
| Holmes, GL | 1 |
| Lai, MC | 1 |
| Hung, PL | 1 |
| Wang, CL | 1 |
| Wang, TJ | 1 |
| Yang, CH | 1 |
| Liou, CW | 1 |
| Yang, SN | 1 |
| Stafstrom, CE | 1 |
| Sasaki-Adams, DM | 1 |
| Fernandez, F | 1 |
| Morishita, W | 1 |
| Zuniga, E | 1 |
| Nguyen, J | 1 |
| Blank, M | 1 |
| Malenka, RC | 1 |
| Garner, CC | 1 |
| He, J | 1 |
| Ma, SL | 1 |
| Rueda, N | 1 |
| Flórez, J | 1 |
| Martínez-Cué, C | 1 |
| Goodnick, P | 1 |
| Gershon, S | 1 |
1 review available for pentylenetetrazole and Cognition Disorders
| Article | Year |
|---|---|
Chemotherapy of cognitive disorders in geriatric subjects.
Topics: Adrenocorticotropic Hormone; Aged; Aging; Alzheimer Disease; Arecoline; Brain Chemistry; Choline; Co | 1984 |
1 trial available for pentylenetetrazole and Cognition Disorders
| Article | Year |
|---|---|
Pre- and post-conditioning treatment with an ultra-low dose of Δ9-tetrahydrocannabinol (THC) protects against pentylenetetrazole (PTZ)-induced cognitive damage.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cognition Disorders; Disease Models, Animal; Dose-R | 2011 |
27 other studies available for pentylenetetrazole and Cognition Disorders
| Article | Year |
|---|---|
Response to sertraline and antiepileptic drugs in pentylenetetrazole kindling in rats.
Topics: Animals; Anticonvulsants; Avoidance Learning; Cognition Disorders; Convulsants; Glutathione; Kindlin | 2021 |
Suppression of BACE1 and amyloidogenic/RAGE axis by sitagliptin ameliorates PTZ kindling-induced cognitive deficits in rats.
Topics: Amyloid; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopep | 2020 |
P38 MAPK pathway mediates cognitive damage in pentylenetetrazole-induced epilepsy via apoptosis cascade.
Topics: Analysis of Variance; Animals; Apoptosis; Caspase 3; Cognition Disorders; Convulsants; Disease Model | 2017 |
Possible nitric oxide mechanism in the protective effect of hesperidin against pentylenetetrazole (PTZ)-induced kindling and associated cognitive dysfunction in mice.
Topics: Animals; Avoidance Learning; Brain; Cognition Disorders; Convulsants; Disease Models, Animal; Dose-R | 2013 |
Cognitive performance and convulsion risk after experimentally-induced febrile-seizures in rat.
Topics: Analysis of Variance; Animals; Cognition Disorders; Convulsants; Disease Models, Animal; Dose-Respon | 2014 |
Naringin ameliorates pentylenetetrazol-induced seizures and associated oxidative stress, inflammation, and cognitive impairment in rats: possible mechanisms of neuroprotection.
Topics: Animals; Cognition Disorders; Convulsants; Flavanones; Inflammation; Neuroprotective Agents; Oxidati | 2014 |
Effects of a lyophilized aqueous extract of Feretia apodanthera Del. (Rubiaceae) on pentylenetetrazole-induced kindling, oxidative stress, and cognitive impairment in mice.
Topics: Acetylcholinesterase; Animals; Anxiety; Cognition; Cognition Disorders; Convulsants; Freeze Drying; | 2015 |
Effect of GLT-1 modulator and P2X7 antagonists alone and in combination in the kindling model of epilepsy in rats.
Topics: Animals; Brain; Ceftriaxone; Cognition Disorders; Convulsants; Dose-Response Relationship, Drug; Epi | 2015 |
Omega 3 polyunsaturated fatty acids enhance the protective effect of levetiracetam against seizures, cognitive impairment and hippocampal oxidative DNA damage in young kindled rats.
Topics: Animals; Anticonvulsants; Anxiety; Avoidance Learning; Cognition Disorders; Convulsants; DNA Damage; | 2015 |
Protective effect on phenytoin-induced cognition deficit in pentylenetetrazol kindled mice: A repertoire of Glycyrrhiza glabra flavonoid antioxidants.
Topics: Acetates; Animals; Anticonvulsants; Antioxidants; Behavior, Animal; Brain; Cognition; Cognition Diso | 2016 |
Quetiapine attenuates cognitive impairment and decreases seizure susceptibility possibly through promoting myelin development in a rat model of malformations of cortical development.
Topics: Animals; Animals, Newborn; Anticonvulsants; Cerebral Cortex; Cognition Disorders; Corpus Callosum; D | 2015 |
Panchagavya Ghrita, an Ayurvedic formulation attenuates seizures, cognitive impairment and oxidative stress in pentylenetetrazole induced seizures in rats.
Topics: Analysis of Variance; Animals; Avoidance Learning; Brain Chemistry; Cognition Disorders; Glutathione | 2015 |
Crocin Attenuates Kindling Development and Associated Cognitive Impairments in Mice via Inhibiting Reactive Oxygen Species-Mediated NF-κB Activation.
Topics: Animals; Carotenoids; Cognition Disorders; Cognitive Dysfunction; Crocus; Disease Models, Animal; Do | 2017 |
Effect of carbamazepine and lamotrigine on cognitive function and oxidative stress in brain during chemical epileptogenesis in rats.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Catalase; Cognition; Cognition D | 2010 |
Hydroalcoholic extract of Emblica officinalis Gaertn. affords protection against PTZ-induced seizures, oxidative stress and cognitive impairment in rats.
Topics: Animals; Anticonvulsants; Antioxidants; Brain Chemistry; Cognition Disorders; Convulsants; Drug Eval | 2010 |
Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model.
Topics: Administration, Oral; Animals; Anticonvulsants; Antioxidants; Avoidance Learning; Cognition Disorder | 2010 |
Effect of lamotrigine, oxcarbazepine and topiramate on cognitive functions and oxidative stress in PTZ-kindled mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Catalase; Cognition Disorders; Disease Models, Animal; Drug | 2011 |
Root extract of Anacyclus pyrethrum ameliorates seizures, seizure-induced oxidative stress and cognitive impairment in experimental animals.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Avoidance Learning; Brain; Butyrylcholinesteras | 2012 |
Hyperthermic seizures enhance responsiveness to pentylenetetrazole and induce cognitive dysfunction: protective effect of 3-alkynyl selenophene.
Topics: Animals; Anticonvulsants; Cognition Disorders; Convulsants; Diazepam; Hyperthermia, Induced; Male; M | 2012 |
Environmental enrichment restores cognitive deficits induced by prenatal maternal seizure.
Topics: Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Cell Count; Cognition Disorders; Convu | 2012 |
A single pentylenetetrazole-induced clonic-tonic seizure episode is accompanied by a slowly developing cognitive decline in rats.
Topics: Animals; Cell Proliferation; Cognition Disorders; Disease Progression; Hippocampus; Male; Maze Learn | 2013 |
Maternal deprivation stress exacerbates cognitive deficits in immature rats with recurrent seizures.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Cognition Disorders; Cyclic AMP Response Element | 2002 |
NMDA-induced seizures in developing rats cause long-term learning impairment and increased seizure susceptibility.
Topics: Animals; Animals, Newborn; Brain; Cognition Disorders; Convulsants; Electroencephalography; Excitato | 2003 |
Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome.
Topics: Animals; Behavior, Animal; Cognition Disorders; Disease Models, Animal; Down Syndrome; Electric Stim | 2007 |
[Influence of repeated seizures and large dosage anti-epileptic drug on phosphorylated cAMP response element binding protein in rat's hippocampus and effect of Caoguo Zhimu Decoction].
Topics: Animals; Cognition Disorders; Cyclic AMP Response Element-Binding Protein; Drugs, Chinese Herbal; Ep | 2007 |
Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome.
Topics: Acetylcholine; Animals; Brain; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Disease Mod | 2008 |
Stimulants and other drugs for treatment of mental symptoms in the elderly.
Topics: Aged; Central Nervous System Stimulants; Cognition Disorders; Humans; Mental Disorders; Methylphenid | 1978 |