pentylenetetrazole has been researched along with Chronic Disease in 33 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was to evaluate the effects of corilagin, an ellagitannin extracted from medicinal plants, on the frequency of seizures and cognitive function in a rat model of chronic epilepsy." | 7.88 | Corilagin Reduces the Frequency of Seizures and Improves Cognitive Function in a Rat Model of Chronic Epilepsy. ( Chang, LY; Wei, LL; Yu, H; Yu, X; Zhou, T, 2018) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 7.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| "To investigate the mechanisms of histamine on chronic epilepsy induced by pentylenetetrazole (PTZ)." | 7.72 | [Mechanisms of the effect of brain histamine on chronic epilepsy induced by pentylenetetrazole]. ( Chen, Z; Hu, WW; Jin, CL; Shen, HQ; Zhang, LS; Zhao, MH, 2004) |
| "Epilepsy is a chronic neurological disorder which affects 65 million worldwide population and characterized by recurrent seizure in epileptic patients." | 5.48 | The anti-epileptogenic and cognition enhancing effect of novel 1-[4-(4-benzo [1, 3] dioxol-5-ylmethyl-piperazin-1-yl)-phenyl]-3-phenyl-urea (BPPU) in pentylenetetrazole induced chronic rat model of epilepsy. ( Kumari, S; Mishra, CB; Siraj, F; Tiwari, AK; Tiwari, M; Yadav, R, 2018) |
| " The aim of this study was to evaluate the effects of corilagin, an ellagitannin extracted from medicinal plants, on the frequency of seizures and cognitive function in a rat model of chronic epilepsy." | 3.88 | Corilagin Reduces the Frequency of Seizures and Improves Cognitive Function in a Rat Model of Chronic Epilepsy. ( Chang, LY; Wei, LL; Yu, H; Yu, X; Zhou, T, 2018) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 3.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| "Pentylenetetrazol (PTZ)-induced chronic kindling model and lithium-pilocarpine-induced status epilepticus (SE) model were used in this study." | 3.81 | Degeneration and regeneration of GABAergic interneurons in the dentate gyrus of adult mice in experimental models of epilepsy. ( Jiang, W; Wang, Y; Wei, D; Wu, C; Wu, SX; Yang, F, 2015) |
| " In acute study, seizures were induced by either pentylenetetrazole (PTZ) injection or maximal electroshock seizures, while in the chronic study, kindling was induced by injecting PTZ (30 mg/kg, s." | 3.76 | Effect of phosphamidon on convulsive behavior and biochemical parameters: modulation by progesterone and 4'-chlorodiazepam in rats. ( Arora, T; Banerjee, BD; Joshi, V; Mahajan, P; Mediratta, PK; Mehta, AK; Mehta, KD; Rathor, N; Sharma, AK; Sharma, KK, 2010) |
| "To investigate the mechanisms of histamine on chronic epilepsy induced by pentylenetetrazole (PTZ)." | 3.72 | [Mechanisms of the effect of brain histamine on chronic epilepsy induced by pentylenetetrazole]. ( Chen, Z; Hu, WW; Jin, CL; Shen, HQ; Zhang, LS; Zhao, MH, 2004) |
| " In a prospective trial in dogs with newly diagnosed epilepsy, ELB 138 markedly reduced seizure frequency and severity without significant difference to standard treatments (phenobarbital or primidone) but was much better tolerated than the standard drugs." | 3.72 | Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures. ( Löscher, W; Potschka, H; Rieck, S; Rundfeldt, C; Tipold, A, 2004) |
| "We measured the release of neuropeptide Y (NPY) from hippocampal slices of rats at various times after limbic seizures induced by a subcutaneous injection of 12 mg/kg kainic acid (KA)." | 3.69 | Enhanced neuropeptide Y release in the hippocampus is associated with chronic seizure susceptibility in kainic acid treated rats. ( Civenni, G; Messali, S; Monno, A; Rizzi, M; Samanin, R; Vezzani, A, 1994) |
| "Pentylenetetrazole and kainic acid, seizure-inducing agents that are known to increase glucose utilization in brain, were used to produce chronic seizures in mature rats." | 3.69 | Chronic seizures increase glucose transporter abundance in rat brain. ( Drewes, LR; Gerhart, DZ; Gronlund, KM; Leino, RL; McCall, AL, 1996) |
| "Epilepsy is a chronic neurological disorder which affects 65 million worldwide population and characterized by recurrent seizure in epileptic patients." | 1.48 | The anti-epileptogenic and cognition enhancing effect of novel 1-[4-(4-benzo [1, 3] dioxol-5-ylmethyl-piperazin-1-yl)-phenyl]-3-phenyl-urea (BPPU) in pentylenetetrazole induced chronic rat model of epilepsy. ( Kumari, S; Mishra, CB; Siraj, F; Tiwari, AK; Tiwari, M; Yadav, R, 2018) |
| "The different effects of quercetin on seizure threshold may occur through several mechanisms." | 1.43 | Comparison between the effects of quercetin on seizure threshold in acute and chronic seizure models. ( Abbasi, E; Hajiali, F; Mohseni, F; Nassiri-Asl, M; Taghiloo, M; Yousefi, F, 2016) |
| "Although epilepsy is a common neurological disorder, its mechanism(s) are still not completely understood." | 1.40 | Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models. ( Chen, L; Chen, Y; Jiang, G; Li, J; Li, Z; Wang, X; Wang, Z, 2014) |
| "Chronic seizures causes the decrease in tissue CA levels." | 1.29 | [Alimentary modification of catecholamine levels and status of the thiol-dependent protective system in the brain in convulsive syndrome]. ( Alekseeva, NR; Ikkert, OV; Sarbaev, BT; Sydykov, BU; Tazhibaev, ShS; Tishchenko, EG; Zhumasheva, LZh, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (12.12) | 18.7374 |
| 1990's | 4 (12.12) | 18.2507 |
| 2000's | 9 (27.27) | 29.6817 |
| 2010's | 14 (42.42) | 24.3611 |
| 2020's | 2 (6.06) | 2.80 |
| Authors | Studies |
|---|---|
| Mishra, P | 1 |
| Mittal, AK | 1 |
| Rajput, SK | 1 |
| Sinha, JK | 1 |
| Ahmed, H | 1 |
| Khan, MA | 1 |
| Hashemian, M | 2 |
| Anissian, D | 1 |
| Ghasemi-Kasman, M | 2 |
| Akbari, A | 1 |
| Khalili-Fomeshi, M | 2 |
| Ghasemi, S | 1 |
| Ahmadi, F | 1 |
| Moghadamnia, AA | 2 |
| Ebrahimpour, A | 1 |
| Abdel-Wahab, AF | 1 |
| Afify, MA | 1 |
| Mahfouz, AM | 1 |
| Shahzad, N | 1 |
| Bamagous, GA | 1 |
| Al Ghamdi, SS | 1 |
| Yu, X | 1 |
| Zhou, T | 1 |
| Yu, H | 2 |
| Chang, LY | 1 |
| Wei, LL | 1 |
| Mishra, CB | 1 |
| Kumari, S | 2 |
| Siraj, F | 1 |
| Yadav, R | 1 |
| Tiwari, AK | 1 |
| Tiwari, M | 1 |
| Mansoor, SR | 1 |
| Ashrafpour, M | 1 |
| Nassiri-Asl, M | 1 |
| Hajiali, F | 1 |
| Taghiloo, M | 1 |
| Abbasi, E | 1 |
| Mohseni, F | 1 |
| Yousefi, F | 1 |
| Li, J | 1 |
| Jiang, G | 1 |
| Chen, Y | 1 |
| Chen, L | 2 |
| Li, Z | 1 |
| Wang, Z | 1 |
| Wang, X | 1 |
| Wei, D | 1 |
| Yang, F | 2 |
| Wang, Y | 1 |
| Wu, C | 1 |
| Wu, SX | 1 |
| Jiang, W | 1 |
| Snehunsu, A | 1 |
| Ghosal, C | 1 |
| Kandwal, M | 1 |
| Yadav, PK | 1 |
| Nayak, BS | 1 |
| Rao, KR | 1 |
| Kamath, SU | 1 |
| Sahoo, P | 1 |
| Srinivasan, KK | 1 |
| Naduvil Narayanan, S | 1 |
| Kumar, S | 1 |
| Joseph, A | 1 |
| Pontes, JC | 1 |
| Lima, TZ | 1 |
| Queiroz, CM | 1 |
| Cinini, SM | 1 |
| Blanco, MM | 1 |
| Mello, LE | 1 |
| Qi, GL | 1 |
| Wang, J | 1 |
| Deng, Z | 1 |
| Zhao, YS | 1 |
| Lei, SS | 1 |
| Zhu, XQ | 1 |
| Rebrov, IG | 1 |
| Karpova, MN | 1 |
| Andreev, AA | 1 |
| Klishina, NY | 1 |
| Kalinina, MV | 1 |
| Kusnetzova, LV | 1 |
| Joshi, V | 1 |
| Arora, T | 1 |
| Mehta, AK | 1 |
| Sharma, AK | 1 |
| Rathor, N | 1 |
| Mehta, KD | 1 |
| Mahajan, P | 1 |
| Mediratta, PK | 1 |
| Banerjee, BD | 1 |
| Sharma, KK | 1 |
| Xie, W | 1 |
| Yu, Y | 1 |
| Zhao, Y | 1 |
| Zhang, B | 1 |
| Wong, M | 1 |
| HAYDU, GG | 1 |
| LANGE, HS | 1 |
| WHITTIER, JR | 1 |
| Zhang, LS | 2 |
| Shen, HQ | 1 |
| Jin, CL | 2 |
| Hu, WW | 1 |
| Zhao, MH | 1 |
| Chen, Z | 2 |
| Li, Q | 1 |
| Sun, YC | 1 |
| Cavazos, JE | 1 |
| Jones, SM | 1 |
| Cross, DJ | 1 |
| De Sarro, G | 1 |
| Ibbadu, GF | 1 |
| Marra, R | 1 |
| Rotiroti, D | 1 |
| Loiacono, A | 1 |
| Donato Di Paola, E | 1 |
| Russo, E | 1 |
| Löscher, W | 1 |
| Potschka, H | 1 |
| Rieck, S | 1 |
| Tipold, A | 1 |
| Rundfeldt, C | 1 |
| Tchekalarova, J | 1 |
| Georgiev, V | 1 |
| Vezzani, A | 1 |
| Civenni, G | 1 |
| Rizzi, M | 1 |
| Monno, A | 1 |
| Messali, S | 1 |
| Samanin, R | 1 |
| Tazhibaev, ShS | 1 |
| Ikkert, OV | 1 |
| Zhumasheva, LZh | 1 |
| Tishchenko, EG | 1 |
| Sydykov, BU | 1 |
| Sarbaev, BT | 1 |
| Alekseeva, NR | 1 |
| Gronlund, KM | 1 |
| Gerhart, DZ | 1 |
| Leino, RL | 1 |
| McCall, AL | 1 |
| Drewes, LR | 1 |
| Karpova, MH | 1 |
| Abrosimov, IIu | 1 |
| Kryzhanovskiĭ, GN | 1 |
| Golarai, G | 1 |
| Greenwood, AC | 1 |
| Feeney, DM | 1 |
| Connor, JA | 1 |
| Bruins Slot, LA | 1 |
| Tarayre, JP | 1 |
| Koek, W | 1 |
| Ribet, JP | 1 |
| Colpaert, FC | 1 |
| Testa, G | 1 |
| Gloor, P | 1 |
| Stotsky, BA | 1 |
| Cole, JO | 1 |
| Lu, LM | 1 |
| Sniffin, CM | 1 |
| Gaetti, R | 1 |
1 trial available for pentylenetetrazole and Chronic Disease
| Article | Year |
|---|---|
A controlled study of the efficacy of pentylenetetrazol (Metrazol) with hard-core hospitalized psychogeriatric patients.
Topics: Aged; Analysis of Variance; Chronic Disease; Clinical Trials as Topic; Dementia; Evaluation Studies | 1972 |
32 other studies available for pentylenetetrazole and Chronic Disease
| Article | Year |
|---|---|
Cognition and memory impairment attenuation via reduction of oxidative stress in acute and chronic mice models of epilepsy using antiepileptogenic Nux vomica.
Topics: Acute Disease; Animals; Anticonvulsants; Antioxidants; Behavior, Animal; Brain; Chronic Disease; Cog | 2021 |
Evaluation of cytokines expression in the phytoflavonoids treated epileptic rats: An in vivo study.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Brain; Chronic Disease; Cytokines; Disease Model | 2020 |
Curcumin-loaded chitosan-alginate-STPP nanoparticles ameliorate memory deficits and reduce glial activation in pentylenetetrazol-induced kindling model of epilepsy.
Topics: Animals; Anticonvulsants; Brain; Chronic Disease; Curcumin; Disease Models, Animal; Dose-Response Re | 2017 |
Vitamin D enhances antiepileptic and cognitive effects of lamotrigine in pentylenetetrazole-kindled rats.
Topics: Animals; Anticonvulsants; Antioxidants; Cholecalciferol; Chronic Disease; Cognition; Disease Models, | 2017 |
Corilagin Reduces the Frequency of Seizures and Improves Cognitive Function in a Rat Model of Chronic Epilepsy.
Topics: Animals; Biomarkers; Brain; Carbonic Anhydrases; Catalase; Cell Count; Chronic Disease; Cognition; C | 2018 |
The anti-epileptogenic and cognition enhancing effect of novel 1-[4-(4-benzo [1, 3] dioxol-5-ylmethyl-piperazin-1-yl)-phenyl]-3-phenyl-urea (BPPU) in pentylenetetrazole induced chronic rat model of epilepsy.
Topics: Animals; Cerebral Cortex; Chronic Disease; Cognition; Cognitive Dysfunction; Disease Models, Animal; | 2018 |
Upregulation of klotho and erythropoietin contributes to the neuroprotection induced by curcumin-loaded nanoparticles in experimental model of chronic epilepsy.
Topics: Animals; Chronic Disease; Curcumin; Disease Models, Animal; DNA-Binding Proteins; Drug Carriers; Epi | 2018 |
Comparison between the effects of quercetin on seizure threshold in acute and chronic seizure models.
Topics: Acute Disease; Administration, Oral; Animals; Anticonvulsants; Chronic Disease; Convulsants; Disease | 2016 |
Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models.
Topics: Acute Disease; Amino Acids, Dicarboxylic; Animals; Brain; Central Nervous System Agents; Chronic Dis | 2014 |
Degeneration and regeneration of GABAergic interneurons in the dentate gyrus of adult mice in experimental models of epilepsy.
Topics: Animals; Chronic Disease; Dentate Gyrus; Epilepsy; GABAergic Neurons; Glutamate Decarboxylase; Green | 2015 |
1-Triacontanol cerotate; isolated from Marsilea quadrifolia Linn. ameliorates reactive oxidative damage in the frontal cortex and hippocampus of chronic epileptic rats.
Topics: Animals; Chronic Disease; Dose-Response Relationship, Drug; Epilepsy, Generalized; Fatty Alcohols; F | 2015 |
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment.
Topics: Animals; Anticonvulsants; Brain; Callithrix; Carbamazepine; Chronic Disease; Disease Models, Animal; | 2016 |
Aquaporin 4 inhibition decreased synthesis of cytokines by acetazolamide in the hippocampus of rats with pentrazol-induced chronic epilepsy.
Topics: Acetazolamide; Animals; Aquaporin 4; Chronic Disease; Cytokines; Epilepsy; Hippocampus; Kindling, Ne | 2016 |
Cl(-) conduction of GABAA receptor complex of synaptic membranes in the cortex of rats at the middle stage of chronic cerebral epileptization (pharmacological kindling).
Topics: Animals; Cerebral Cortex; Chlorides; Chronic Disease; Dose-Response Relationship, Drug; Epilepsy; GA | 2007 |
Effect of phosphamidon on convulsive behavior and biochemical parameters: modulation by progesterone and 4'-chlorodiazepam in rats.
Topics: Acetylcholinesterase; Acute Disease; Animals; Antioxidants; Behavior, Animal; Brain; Chronic Disease | 2010 |
[Effect of Chaihu Shugan Tang on excitability in different brain regions of pentylenetetrazole-kindled chronic epileptic rats].
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Aspartic Acid; Brain; Chronic Disease; Deoxyglucose; Disease | 2010 |
Pentylenetetrazole-induced seizures cause acute, but not chronic, mTOR pathway activation in rat.
Topics: Acute Disease; Animals; Chronic Disease; Convulsants; Disease Models, Animal; Enzyme Activation; Epi | 2012 |
Effects of Metrazolvitamin administration in chronic psychoses.
Topics: Chronic Disease; Mental Disorders; Nutrition Therapy; Pentylenetetrazole; Psychotic Disorders; Vitam | 1961 |
[Mechanisms of the effect of brain histamine on chronic epilepsy induced by pentylenetetrazole].
Topics: Animals; Brain; Chronic Disease; Dose-Response Relationship, Drug; Epilepsy; Histamine; Histidine; I | 2004 |
[Influence of chronic epilepsy on spatial memory retrieval in rats].
Topics: Animals; Benzazepines; Chronic Disease; Dose-Response Relationship, Drug; Epilepsy; Male; Maze Learn | 2004 |
Sprouting and synaptic reorganization in the subiculum and CA1 region of the hippocampus in acute and chronic models of partial-onset epilepsy.
Topics: Acute Disease; Animals; Chronic Disease; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lob | 2004 |
Seizure susceptibility to various convulsant stimuli in dystrophin-deficient mdx mice.
Topics: Acute Disease; Animals; Chronic Disease; Convulsants; Disease Models, Animal; Dystrophin; Epilepsy; | 2004 |
Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures.
Topics: Animals; Anticonvulsants; Bromides; Chronic Disease; Disease Models, Animal; Dog Diseases; Dogs; Dru | 2004 |
Effect of acute versus chronic theophylline administration on acute restraint stress-induced increase of pentylenetetrazol seizure threshold in mice.
Topics: Acute Disease; Animals; Anticonvulsants; Chronic Disease; Convulsants; Dose-Response Relationship, D | 2006 |
Enhanced neuropeptide Y release in the hippocampus is associated with chronic seizure susceptibility in kainic acid treated rats.
Topics: Animals; Antibodies; Chronic Disease; Disease Susceptibility; Dose-Response Relationship, Drug; Elec | 1994 |
[Alimentary modification of catecholamine levels and status of the thiol-dependent protective system in the brain in convulsive syndrome].
Topics: Animals; Brain; Catecholamines; Chronic Disease; Diet; Glutathione Peroxidase; Glutathione Transfera | 1993 |
Chronic seizures increase glucose transporter abundance in rat brain.
Topics: Animals; Brain; Chronic Disease; Glucose Transporter Type 1; Glucose Transporter Type 3; Immunoblott | 1996 |
[Effect of cerebral ischemia of various severity on acute seizures and chronic epileptogenesis].
Topics: Acute Disease; Animals; Arterial Occlusive Diseases; Brain Ischemia; Carotid Artery Diseases; Chroni | 1998 |
Physiological and structural evidence for hippocampal involvement in persistent seizure susceptibility after traumatic brain injury.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Injuries; Cell Count; Cell Death; Chronic Disease; Denta | 2001 |
Experimental conditions for the continuous subcutaneous infusion of four central analgesics in rats.
Topics: Acetates; Amines; Analgesics; Anesthetics, Dissociative; Animals; Anticonvulsants; Antidepressive Ag | 2002 |
Intracarotid pentylenetetrazol injections in the cat.
Topics: Acute Disease; Animals; Carotid Arteries; Cats; Chronic Disease; Electroencephalography; Epilepsies, | 1974 |
[Clinical experience with Cardiazol-Paracodin in bronchopathies of aged persons].
Topics: Acute Disease; Aged; Aging; Bronchitis; Chronic Disease; Cough; Drug Combinations; Humans; Laryngiti | 1972 |