pentylenetetrazole has been researched along with Chemical Dependence in 29 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Anxiety disorders and substance abuse, including benzodiazepine use disorder, frequently occur together." | 1.39 | Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans. ( Augustin, I; Begemann, M; Brose, N; Ehrenreich, H; Gurvich, A; Ju, A; Man, KN; Müller-Ribbe, K; Papiol, S; Ronnenberg, A; Shin, Y; Stepniak, B; Tantra, M; Wojcik, SM, 2013) |
| "Alpidem is a new anxiolytic of imidazopyridine structure which has a high affinity for the omega 1 (BZ1) modulatory site of the GABAA receptor." | 1.29 | Repeated treatment with alpidem, a new anxiolytic, does not induce tolerance or physical dependence. ( Morel, E; Perrault, G; Sanger, DJ; Zivkovic, B, 1993) |
| " Using a cumulative dosing procedure, PTZ substituted for PTZ, and MDZ, chlordiazepoxide and diazepam (DZP) substituted for MDZ, in a dose-dependent manner." | 1.28 | Tolerance, cross-tolerance and withdrawal in rats made dependent on diazepam. ( Boone, MS; Emmett-Oglesby, MW; Pugh, SL, 1992) |
| " In the pair-fed controls, or rats withdrawn from the smaller dosage of either ethanol or cocaine, the test dose of saline or cocaine did not elicit the PTZ-stimulus; only 30% of rats selected the PTZ-appropriate level at the highest dose of cocaine tested (10 mg/kg)." | 1.28 | Protracted withdrawal: sensitization of the anxiogenic response to cocaine in rats concurrently treated with ethanol. ( Lal, H; Prather, PL, 1992) |
| " In a separate experiment, Ro 15-1788 produced a PTZ-like stimulus when given at 2-day intervals during chronic administration of DZP." | 1.27 | Withdrawal from diazepam substitutes for the discriminative stimulus properties of pentylenetetrazol. ( Emmett-Oglesby, MW; Harris, CM; Idemudia, SO; Lal, H; Mathis, DA, 1988) |
| " In the pups of all dosed groups, the convulsive threshold for PTZ is reduced significantly compared with that in the naive group." | 1.26 | Alteration of convulsive threshold and sensitivity to CNS acting drugs in sedative-hypnotics-experienced rat offspring. ( Hiramori, T; Nakao, K; Tagashira, E; Urano, T; Yanaura, S, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (62.07) | 18.7374 |
| 1990's | 7 (24.14) | 18.2507 |
| 2000's | 2 (6.90) | 29.6817 |
| 2010's | 1 (3.45) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Wilson, CD | 1 |
| Zheng, F | 1 |
| Fantegrossi, WE | 1 |
| Wojcik, SM | 1 |
| Tantra, M | 1 |
| Stepniak, B | 1 |
| Man, KN | 1 |
| Müller-Ribbe, K | 1 |
| Begemann, M | 1 |
| Ju, A | 1 |
| Papiol, S | 1 |
| Ronnenberg, A | 1 |
| Gurvich, A | 1 |
| Shin, Y | 1 |
| Augustin, I | 1 |
| Brose, N | 1 |
| Ehrenreich, H | 1 |
| Wiley, JL | 1 |
| Bale, AS | 1 |
| Balster, RL | 1 |
| HARGROVE, EA | 1 |
| FORD, FR | 1 |
| Listos, J | 1 |
| Talarek, S | 1 |
| Fidecka, S | 1 |
| Emmett-Oglesby, MW | 3 |
| Spencer, DG | 1 |
| Lewis, MW | 1 |
| Lal, H | 3 |
| Rigter, H | 1 |
| Rijk, H | 1 |
| Crabbe, JC | 1 |
| Tagashira, E | 1 |
| Nakao, K | 1 |
| Urano, T | 1 |
| Hiramori, T | 1 |
| Yanaura, S | 1 |
| Perrault, G | 1 |
| Morel, E | 1 |
| Sanger, DJ | 1 |
| Zivkovic, B | 1 |
| Jacobsen, EJ | 1 |
| Stelzer, LS | 1 |
| Belonga, KL | 1 |
| Carter, DB | 1 |
| Im, WB | 1 |
| Sethy, VH | 1 |
| Tang, AH | 1 |
| VonVoigtlander, PF | 1 |
| Petke, JD | 1 |
| Martin, JR | 1 |
| Moreau, JL | 1 |
| Jenck, F | 1 |
| Pieri, L | 1 |
| Garibova, TL | 1 |
| Val'dman, EA | 1 |
| Voronina, TA | 1 |
| Kraĭneva, VA | 1 |
| Pircio, AW | 1 |
| Gylys, JA | 1 |
| Cavanagh, RL | 1 |
| Buyniski, JP | 1 |
| Bierwagen, ME | 1 |
| Lin, SC | 1 |
| Sutherland, VC | 1 |
| Gildea, ML | 1 |
| Bourn, WM | 1 |
| Hoffman, PL | 1 |
| Ritzmann, RF | 2 |
| Tabokoff, B | 1 |
| Tabakoff, B | 1 |
| Ho, IK | 2 |
| Yamamoto, I | 1 |
| Loh, HH | 1 |
| Pugh, SL | 1 |
| Boone, MS | 1 |
| Prather, PL | 1 |
| Steketee, JD | 1 |
| Sorg, BA | 1 |
| Kalivas, PW | 1 |
| Ito, Y | 1 |
| Saunders, PA | 1 |
| Lim, DK | 1 |
| Mathis, DA | 1 |
| Harris, CM | 1 |
| Idemudia, SO | 1 |
| Arblaster, CI | 1 |
| Cameron, DW | 1 |
| Laycock, GM | 1 |
| Shulman, A | 1 |
| Scherkl, R | 1 |
| Scheuler, W | 1 |
| Frey, HH | 1 |
| Hofling, CK | 1 |
| Winslow, WW | 1 |
| Kellner, R | 1 |
| Winters, WD | 1 |
| Ratcliffe, F | 1 |
| Jaffe, JH | 1 |
| Sharpless, SK | 1 |
1 review available for pentylenetetrazole and Chemical Dependence
| Article | Year |
|---|---|
Drug therapy.
Topics: Affective Symptoms; Antidepressive Agents; Butyrophenones; Cannabis; Clinical Trials as Topic; Human | 1972 |
1 trial available for pentylenetetrazole and Chemical Dependence
| Article | Year |
|---|---|
Drug therapy.
Topics: Affective Symptoms; Antidepressive Agents; Butyrophenones; Cannabis; Clinical Trials as Topic; Human | 1972 |
28 other studies available for pentylenetetrazole and Chemical Dependence
| Article | Year |
|---|---|
Convulsant doses of abused synthetic cannabinoid receptor agonists AB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA and JWH-018 do not elicit electroencephalographic (EEG) seizures in male mice.
Topics: Animals; Benzodiazepines; Cannabinoid Receptor Agonists; Cannabinoids; Convulsants; Diazepam; Electr | 2022 |
Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Diazepam; Female; Humans; | 2013 |
Evaluation of toluene dependence and cross-sensitization to diazepam.
Topics: Animals; Convulsants; Diazepam; Excitatory Amino Acid Agonists; Inhalation Exposure; Male; Mice; Mot | 2003 |
Acute and chronic barbiturate intoxication recent advances in therapeutic management.
Topics: Barbiturates; Combined Modality Therapy; Conduct Disorder; Death; Disease Management; Drug Overdose; | 1952 |
Adenosine receptor agonists attenuate the development of diazepam withdrawal-induced sensitization in mice.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine-5'-(N-ethylcarb | 2008 |
Bioassay of subjective effects associated with benzodiazepine withdrawal in animals: a novel direction in dependence research.
Topics: Animals; Benzodiazepinones; Biological Assay; Clonidine; Conditioning, Operant; Diazepam; Discrimina | 1984 |
Tolerance to ethanol and severity of withdrawal in mice are enhanced by a vasopressin fragment.
Topics: Animals; Arginine Vasopressin; Drug Tolerance; Ethanol; Humans; Mice; Pentylenetetrazole; Pyrazoles; | 1980 |
Alteration of convulsive threshold and sensitivity to CNS acting drugs in sedative-hypnotics-experienced rat offspring.
Topics: Animals; Animals, Newborn; Animals, Suckling; Ethanol; Female; Humans; Hypnotics and Sedatives; Moto | 1982 |
Repeated treatment with alpidem, a new anxiolytic, does not induce tolerance or physical dependence.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Carbolines; Convulsants; Diazepam; Drug | 1993 |
3-Phenyl-substituted imidazo[1,5-alpha]quinoxalin-4-ones and imidazo[1,5-alpha]quinoxaline ureas that have high affinity at the GABAA/benzodiazepine receptor complex.
Topics: Animals; Anticonvulsants; Benzodiazepines; Cell Membrane; Cerebral Cortex; Drug Synergism; Ethanol; | 1996 |
Sarmazenil-precipitated withdrawal: a reliable method for assessing dependence liability of benzodiazepine receptor ligands.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Convulsants; Diazepam; Drug Toleran | 1998 |
[Effect of calcium channel blocker nifedipine on anxiety and seizure manifestations of abstinence syndrome in rats after withdrawal of long-term diazepam administration].
Topics: Adaptation, Physiological; Animals; Anti-Anxiety Agents; Anxiety; Calcium Channel Blockers; Calcium | 1998 |
The pharmacology of butorphanol, a 3,14-dihydroxymorphinan narcotic antagonist analgesic.
Topics: Analgesics; Animals; Behavior, Animal; Cyclobutanes; Dogs; Drug Tolerance; Female; Haplorhini; Hemod | 1976 |
Regional distribution of barbital in the brain of mice during the development of tolerance and physical dependence.
Topics: Animals; Barbital; Barbiturates; Brain; Drug Implants; Drug Tolerance; Humans; Male; Mice; Mice, Inb | 1977 |
Effect of barbiturate withdrawal on pentylenetetrazol seizure threshold.
Topics: Animals; Barbiturates; Cerebral Cortex; Electroencephalography; Evoked Potentials; Humans; Male; Pen | 1977 |
The influence of arginine vasopressin and oxytocin on ethanol dependence and tolerance.
Topics: Animals; Arginine Vasopressin; Drug Tolerance; Ethanol; Humans; Male; Metabolic Clearance Rate; Mice | 1979 |
Dissociation of alcohol tolerance and dependence.
Topics: Alcoholic Intoxication; Animals; Drug Tolerance; Humans; Hydroxydopamines; Hypothermia; Male; Mice; | 1976 |
A model for the rapid development of dispositional and functional tolerance to barbiturates.
Topics: Animals; Barbiturates; Drug Tolerance; Half-Life; Humans; Male; Mice; Mice, Inbred ICR; Microsomes, | 1975 |
Tolerance, cross-tolerance and withdrawal in rats made dependent on diazepam.
Topics: Animals; Chlordiazepoxide; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Drug | 1992 |
Protracted withdrawal: sensitization of the anxiogenic response to cocaine in rats concurrently treated with ethanol.
Topics: Alcoholism; Animals; Anxiety; Cocaine; Discrimination Learning; Discrimination, Psychological; Drug | 1992 |
The role of the nucleus accumbens in sensitization to drugs of abuse.
Topics: Animals; Cocaine; Dialysis; Dopamine; Electroshock; Extracellular Space; Male; Motor Activity; Nucle | 1992 |
Binding characteristics of t-[35S]butylbicyclophosphorothionate in discrete brain regions of rats made tolerant to and dependent on pentobarbital.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Com | 1989 |
Withdrawal from diazepam substitutes for the discriminative stimulus properties of pentylenetetrazol.
Topics: Animals; Diazepam; Discrimination Learning; Disease Models, Animal; Flumazenil; Male; Pentylenetetra | 1988 |
Studies on the development of physical dependence on barbitone in the rat and rat atrium.
Topics: Animals; Barbital; Barbiturates; Bemegride; Calcium Chloride; Convulsants; Drug Tolerance; Electric | 1986 |
Anticonvulsant effect of clonazepam in the dog: development of tolerance and physical dependence.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Clonazepam; Dogs; Drug Tolerance; Electroencephalograph | 1985 |
Epilepsy or anesthesia with ketamine.
Topics: Anesthesia; Anesthetics; Animals; Cataplexy; Cats; Central Nervous System; Cyclohexanes; Depression; | 1972 |
Ethanol dependence in the rat: its production and characteristics.
Topics: Alcoholism; Animals; Auditory Threshold; Behavior, Animal; Electroshock; Ethanol; Female; Humans; Pe | 1972 |
The rapid development of physical dependence on barbiturates.
Topics: Animals; Cats; Denervation; Humans; Pentobarbital; Pentylenetetrazole; Seizures; Substance Withdrawa | 1965 |