pentylenetetrazole has been researched along with Cerebral Micropolygyria in 2 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Intraperitoneal pentylenetetrazole injection did not induce any seizure activity in the control rats, although it elicited seizures of variable severity in the polymicrogyria rats." | 3.81 | Increased expression of GAP43 in interneurons in a rat model of experimental polymicrogyria. ( Matsui, K; Takano, T, 2015) |
| "Malformations of the polymicrogyria spectrum can be mimicked in rodents through neonatal transcranial focal cortical freeze lesions." | 1.72 | Altered excitatory and inhibitory neocortical circuitry leads to increased convulsive severity after pentylenetetrazol injection in an animal model of schizencephaly, but not of microgyria. ( Adriani Marques, S; Blanco Martinez, AM; Borges Savoldi, LM; Campello Costa Lopes, P; de Souza Aguiar Dos Santos, DM; Dos Santos Heringer, L; Magalhães Portela, D; Martinez Martinez Toledo, AL; Rios Carvalho, J; Rocha Mendonça, H; Teixeira Oliveira, J; Texeira Silva, B, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dos Santos Heringer, L | 1 |
| Rios Carvalho, J | 1 |
| Teixeira Oliveira, J | 1 |
| Texeira Silva, B | 1 |
| de Souza Aguiar Dos Santos, DM | 1 |
| Martinez Martinez Toledo, AL | 1 |
| Borges Savoldi, LM | 1 |
| Magalhães Portela, D | 1 |
| Adriani Marques, S | 1 |
| Campello Costa Lopes, P | 1 |
| Blanco Martinez, AM | 1 |
| Rocha Mendonça, H | 1 |
| Takano, T | 1 |
| Matsui, K | 1 |
2 other studies available for pentylenetetrazole and Cerebral Micropolygyria
| Article | Year |
|---|---|
Altered excitatory and inhibitory neocortical circuitry leads to increased convulsive severity after pentylenetetrazol injection in an animal model of schizencephaly, but not of microgyria.
Topics: Animals; Disease Models, Animal; GAP-43 Protein; Mice; Neocortex; Pentylenetetrazole; Polymicrogyria | 2022 |
Increased expression of GAP43 in interneurons in a rat model of experimental polymicrogyria.
Topics: Animals; Animals, Newborn; Brain; Disease Models, Animal; Female; GAP-43 Protein; Ibotenic Acid; Int | 2015 |