pentylenetetrazole has been researched along with Cerebral Ischemia in 11 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We demonstrated that right common carotid ligation decreases the threshold for clonic seizures induced by pentylenetetrazole (PTZ), a GABA antagonist." | 3.81 | Hypoxia/ischemia a key player in early post stroke seizures: modulation by opioidergic and nitrergic systems. ( Abdolghaffari, AH; Aleyasin, AR; Azizi, Y; Chabouk, L; Dehpour, AR; Gooshe, M; Hassanzadeh, GR; Partoazar, A; Payandemehr, B; Tofigh, S, 2015) |
| " To examine the mechanisms underlying these seizures, we determined the impact of prior forebrain ischemia on the seizure thresholds of four convulsants with differing modes of action: lidocaine, pentylenetetrazol (PTZ), N-methyl-D-aspartate (NMDA), and picrotoxin." | 3.70 | Forebrain ischemia: effect on pharmacologically induced seizure thresholds in the rat. ( Kim, DC; Todd, MM, 1999) |
| "Changes in cortical extracellular potassium activity ([K+]0), NADH fluorescence, and oxygen consumption were studied in anesthetized cats during pentylenetetrazol seizures." | 3.66 | Effects of ischemia on the removal of extracellular potassium in cat cortex during pentylenetetrazol seizures. ( Mutsuga, N; Schuette, WH; Vern, BA; Whitehouse, WC, 1979) |
| "The results indicate that cardiac arrest did not modify the threshold for electroconvulsions either one or two months, following the surgery." | 1.42 | Seizure susceptibility to electroconvulsions or pentylenetetrazol after complete cerebral ischemia in rats due to cardiac arrest. ( Andres-Mach, M; Czuczwar, SJ; Dudra-Jastrzębska, M; Januszewski, S; Pluta, R; Ułamek-Kozioł, M; Łuszczki, JJ, 2015) |
| "Perinatal stroke is a common cerebrovascular disorder affecting 1 in every 4000 births; typically associated with epilepsy." | 1.39 | Increased susceptibility to pentetrazol-induced seizures in developing rats after cortical photothrombotic ischemic stroke at P7. ( Brima, T; Mareš, P; Otáhal, J, 2013) |
| "In rodent seizure models, tanshinone IIA showed anticonvulsive activity in the mouse 6-Hz psychomotor seizure test in a biphasic manner and modified seizure thresholds in a complex manner for the mouse i." | 1.39 | Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models. ( Buenafe, OE; Crawford, AD; De Borggraeve, W; de Witte, P; Esguerra, CV; Huang, H; Luyten, W; Maes, J; Orellana-Paucar, A; Ying, X, 2013) |
| "In contrast to results obtained when seizures are due to other causes, these results suggest that brain glucose transport is decreased during a seizure if the microvasculature has been previously subjected to ischemia." | 1.26 | Cerebral microvessel 2-deoxy-D-glucose uptake during ischemia-induced seizures. ( Nell, JH; Welch, KM, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brima, T | 1 |
| Otáhal, J | 1 |
| Mareš, P | 1 |
| Buenafe, OE | 1 |
| Orellana-Paucar, A | 1 |
| Maes, J | 1 |
| Huang, H | 1 |
| Ying, X | 1 |
| De Borggraeve, W | 1 |
| Crawford, AD | 1 |
| Luyten, W | 1 |
| Esguerra, CV | 1 |
| de Witte, P | 1 |
| Nuñez-Figueredo, Y | 1 |
| Ramírez-Sánchez, J | 1 |
| Delgado-Hernández, R | 1 |
| Porto-Verdecia, M | 1 |
| Ochoa-Rodríguez, E | 1 |
| Verdecia-Reyes, Y | 1 |
| Marin-Prida, J | 1 |
| González-Durruthy, M | 1 |
| Uyemura, SA | 1 |
| Rodrigues, FP | 1 |
| Curti, C | 1 |
| Souza, DO | 1 |
| Pardo-Andreu, GL | 1 |
| Gooshe, M | 1 |
| Abdolghaffari, AH | 1 |
| Aleyasin, AR | 1 |
| Chabouk, L | 1 |
| Tofigh, S | 1 |
| Hassanzadeh, GR | 1 |
| Payandemehr, B | 1 |
| Partoazar, A | 1 |
| Azizi, Y | 1 |
| Dehpour, AR | 1 |
| Dudra-Jastrzębska, M | 1 |
| Ułamek-Kozioł, M | 1 |
| Andres-Mach, M | 1 |
| Łuszczki, JJ | 1 |
| Januszewski, S | 1 |
| Czuczwar, SJ | 1 |
| Pluta, R | 1 |
| Menniti, FS | 1 |
| Buchan, AM | 1 |
| Chenard, BL | 1 |
| Critchett, DJ | 1 |
| Ganong, AH | 1 |
| Guanowsky, V | 1 |
| Seymour, PA | 1 |
| Welch, WM | 1 |
| PAYAN, H | 1 |
| LEVINE, S | 1 |
| STREBEL, R | 1 |
| Nell, JH | 1 |
| Welch, KM | 1 |
| Karpova, MH | 1 |
| Abrosimov, IIu | 1 |
| Kryzhanovskiĭ, GN | 1 |
| Kim, DC | 1 |
| Todd, MM | 1 |
| Vern, BA | 1 |
| Schuette, WH | 1 |
| Mutsuga, N | 1 |
| Whitehouse, WC | 1 |
11 other studies available for pentylenetetrazole and Cerebral Ischemia
| Article | Year |
|---|---|
Increased susceptibility to pentetrazol-induced seizures in developing rats after cortical photothrombotic ischemic stroke at P7.
Topics: Animals; Brain; Brain Ischemia; Convulsants; Disease Models, Animal; Electroencephalography; Epileps | 2013 |
Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models.
Topics: Abietanes; Alzheimer Disease; Animals; Anticonvulsants; Brain Ischemia; Disease Models, Animal; Dise | 2013 |
JM-20, a novel benzodiazepine–dihydropyridine hybrid molecule, protects mitochondria and prevents ischemic insult-mediated neural cell death in vitro.
Topics: Animals; Benzodiazepines; Brain Ischemia; Calcium; Cell Death; Cerebellum; Cytochromes c; Dihydropyr | 2014 |
Hypoxia/ischemia a key player in early post stroke seizures: modulation by opioidergic and nitrergic systems.
Topics: Analgesics, Opioid; Animals; Brain Ischemia; Cell Hypoxia; Drug Synergism; GABA Antagonists; Male; M | 2015 |
Seizure susceptibility to electroconvulsions or pentylenetetrazol after complete cerebral ischemia in rats due to cardiac arrest.
Topics: Animals; Brain Ischemia; Electroshock; Female; Heart Arrest; Pentylenetetrazole; Rats; Rats, Wistar; | 2015 |
CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo.
Topics: Animals; Brain Ischemia; Hippocampus; Male; Motor Activity; Neuroprotective Agents; Pentylenetetrazo | 2003 |
EFFECT OF ANOXIC-ISCHEMIC PROCEDURE ON EXPERIMENTAL EPILEPSY IN THE RAT.
Topics: Brain Ischemia; Cerebral Infarction; Cobalt; Epilepsy; Hypoxia, Brain; Infarction; Ischemic Attack, | 1964 |
Cerebral microvessel 2-deoxy-D-glucose uptake during ischemia-induced seizures.
Topics: Animals; Brain; Brain Ischemia; Deoxy Sugars; Deoxyglucose; Female; Gerbillinae; Male; Microcirculat | 1980 |
[Effect of cerebral ischemia of various severity on acute seizures and chronic epileptogenesis].
Topics: Acute Disease; Animals; Arterial Occlusive Diseases; Brain Ischemia; Carotid Artery Diseases; Chroni | 1998 |
Forebrain ischemia: effect on pharmacologically induced seizure thresholds in the rat.
Topics: Analysis of Variance; Animals; Brain Ischemia; Convulsants; Lidocaine; Male; N-Methylaspartate; Pent | 1999 |
Effects of ischemia on the removal of extracellular potassium in cat cortex during pentylenetetrazol seizures.
Topics: Animals; Blood Pressure; Brain Ischemia; Cats; Cerebral Cortex; Extracellular Space; NAD; Oxygen; Ox | 1979 |