pentylenetetrazole has been researched along with Brain Ischemia in 11 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We demonstrated that right common carotid ligation decreases the threshold for clonic seizures induced by pentylenetetrazole (PTZ), a GABA antagonist." | 3.81 | Hypoxia/ischemia a key player in early post stroke seizures: modulation by opioidergic and nitrergic systems. ( Abdolghaffari, AH; Aleyasin, AR; Azizi, Y; Chabouk, L; Dehpour, AR; Gooshe, M; Hassanzadeh, GR; Partoazar, A; Payandemehr, B; Tofigh, S, 2015) |
| " To examine the mechanisms underlying these seizures, we determined the impact of prior forebrain ischemia on the seizure thresholds of four convulsants with differing modes of action: lidocaine, pentylenetetrazol (PTZ), N-methyl-D-aspartate (NMDA), and picrotoxin." | 3.70 | Forebrain ischemia: effect on pharmacologically induced seizure thresholds in the rat. ( Kim, DC; Todd, MM, 1999) |
| "Changes in cortical extracellular potassium activity ([K+]0), NADH fluorescence, and oxygen consumption were studied in anesthetized cats during pentylenetetrazol seizures." | 3.66 | Effects of ischemia on the removal of extracellular potassium in cat cortex during pentylenetetrazol seizures. ( Mutsuga, N; Schuette, WH; Vern, BA; Whitehouse, WC, 1979) |
| "The results indicate that cardiac arrest did not modify the threshold for electroconvulsions either one or two months, following the surgery." | 1.42 | Seizure susceptibility to electroconvulsions or pentylenetetrazol after complete cerebral ischemia in rats due to cardiac arrest. ( Andres-Mach, M; Czuczwar, SJ; Dudra-Jastrzębska, M; Januszewski, S; Pluta, R; Ułamek-Kozioł, M; Łuszczki, JJ, 2015) |
| "Perinatal stroke is a common cerebrovascular disorder affecting 1 in every 4000 births; typically associated with epilepsy." | 1.39 | Increased susceptibility to pentetrazol-induced seizures in developing rats after cortical photothrombotic ischemic stroke at P7. ( Brima, T; Mareš, P; Otáhal, J, 2013) |
| "In rodent seizure models, tanshinone IIA showed anticonvulsive activity in the mouse 6-Hz psychomotor seizure test in a biphasic manner and modified seizure thresholds in a complex manner for the mouse i." | 1.39 | Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models. ( Buenafe, OE; Crawford, AD; De Borggraeve, W; de Witte, P; Esguerra, CV; Huang, H; Luyten, W; Maes, J; Orellana-Paucar, A; Ying, X, 2013) |
| "In contrast to results obtained when seizures are due to other causes, these results suggest that brain glucose transport is decreased during a seizure if the microvasculature has been previously subjected to ischemia." | 1.26 | Cerebral microvessel 2-deoxy-D-glucose uptake during ischemia-induced seizures. ( Nell, JH; Welch, KM, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brima, T | 1 |
| Otáhal, J | 1 |
| Mareš, P | 1 |
| Buenafe, OE | 1 |
| Orellana-Paucar, A | 1 |
| Maes, J | 1 |
| Huang, H | 1 |
| Ying, X | 1 |
| De Borggraeve, W | 1 |
| Crawford, AD | 1 |
| Luyten, W | 1 |
| Esguerra, CV | 1 |
| de Witte, P | 1 |
| Nuñez-Figueredo, Y | 1 |
| Ramírez-Sánchez, J | 1 |
| Delgado-Hernández, R | 1 |
| Porto-Verdecia, M | 1 |
| Ochoa-Rodríguez, E | 1 |
| Verdecia-Reyes, Y | 1 |
| Marin-Prida, J | 1 |
| González-Durruthy, M | 1 |
| Uyemura, SA | 1 |
| Rodrigues, FP | 1 |
| Curti, C | 1 |
| Souza, DO | 1 |
| Pardo-Andreu, GL | 1 |
| Gooshe, M | 1 |
| Abdolghaffari, AH | 1 |
| Aleyasin, AR | 1 |
| Chabouk, L | 1 |
| Tofigh, S | 1 |
| Hassanzadeh, GR | 1 |
| Payandemehr, B | 1 |
| Partoazar, A | 1 |
| Azizi, Y | 1 |
| Dehpour, AR | 1 |
| Dudra-Jastrzębska, M | 1 |
| Ułamek-Kozioł, M | 1 |
| Andres-Mach, M | 1 |
| Łuszczki, JJ | 1 |
| Januszewski, S | 1 |
| Czuczwar, SJ | 1 |
| Pluta, R | 1 |
| Menniti, FS | 1 |
| Buchan, AM | 1 |
| Chenard, BL | 1 |
| Critchett, DJ | 1 |
| Ganong, AH | 1 |
| Guanowsky, V | 1 |
| Seymour, PA | 1 |
| Welch, WM | 1 |
| PAYAN, H | 1 |
| LEVINE, S | 1 |
| STREBEL, R | 1 |
| Nell, JH | 1 |
| Welch, KM | 1 |
| Karpova, MH | 1 |
| Abrosimov, IIu | 1 |
| Kryzhanovskiĭ, GN | 1 |
| Kim, DC | 1 |
| Todd, MM | 1 |
| Vern, BA | 1 |
| Schuette, WH | 1 |
| Mutsuga, N | 1 |
| Whitehouse, WC | 1 |
11 other studies available for pentylenetetrazole and Brain Ischemia
| Article | Year |
|---|---|
Increased susceptibility to pentetrazol-induced seizures in developing rats after cortical photothrombotic ischemic stroke at P7.
Topics: Animals; Brain; Brain Ischemia; Convulsants; Disease Models, Animal; Electroencephalography; Epileps | 2013 |
Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models.
Topics: Abietanes; Alzheimer Disease; Animals; Anticonvulsants; Brain Ischemia; Disease Models, Animal; Dise | 2013 |
JM-20, a novel benzodiazepine–dihydropyridine hybrid molecule, protects mitochondria and prevents ischemic insult-mediated neural cell death in vitro.
Topics: Animals; Benzodiazepines; Brain Ischemia; Calcium; Cell Death; Cerebellum; Cytochromes c; Dihydropyr | 2014 |
Hypoxia/ischemia a key player in early post stroke seizures: modulation by opioidergic and nitrergic systems.
Topics: Analgesics, Opioid; Animals; Brain Ischemia; Cell Hypoxia; Drug Synergism; GABA Antagonists; Male; M | 2015 |
Seizure susceptibility to electroconvulsions or pentylenetetrazol after complete cerebral ischemia in rats due to cardiac arrest.
Topics: Animals; Brain Ischemia; Electroshock; Female; Heart Arrest; Pentylenetetrazole; Rats; Rats, Wistar; | 2015 |
CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo.
Topics: Animals; Brain Ischemia; Hippocampus; Male; Motor Activity; Neuroprotective Agents; Pentylenetetrazo | 2003 |
EFFECT OF ANOXIC-ISCHEMIC PROCEDURE ON EXPERIMENTAL EPILEPSY IN THE RAT.
Topics: Brain Ischemia; Cerebral Infarction; Cobalt; Epilepsy; Hypoxia, Brain; Infarction; Ischemic Attack, | 1964 |
Cerebral microvessel 2-deoxy-D-glucose uptake during ischemia-induced seizures.
Topics: Animals; Brain; Brain Ischemia; Deoxy Sugars; Deoxyglucose; Female; Gerbillinae; Male; Microcirculat | 1980 |
[Effect of cerebral ischemia of various severity on acute seizures and chronic epileptogenesis].
Topics: Acute Disease; Animals; Arterial Occlusive Diseases; Brain Ischemia; Carotid Artery Diseases; Chroni | 1998 |
Forebrain ischemia: effect on pharmacologically induced seizure thresholds in the rat.
Topics: Analysis of Variance; Animals; Brain Ischemia; Convulsants; Lidocaine; Male; N-Methylaspartate; Pent | 1999 |
Effects of ischemia on the removal of extracellular potassium in cat cortex during pentylenetetrazol seizures.
Topics: Animals; Blood Pressure; Brain Ischemia; Cats; Cerebral Cortex; Extracellular Space; NAD; Oxygen; Ox | 1979 |