pentylenetetrazole has been researched along with Bile Duct Obstruction in 5 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Both opioid and cannabinoid CB(1) receptors may be involved in the dramatic increase in pentylenetetrazole-induced seizure threshold in cholestasis." | 3.74 | Elevation of pentylenetetrazole-induced seizure threshold in cholestatic mice: interaction between opioid and cannabinoid systems. ( Dehpour, AR; Ghasemi, M; Shafaroodi, H, 2008) |
| " The threshold to generalized clonic seizures induced by timed intravenous infusion of pentylenetetrazole (PTZ) was used as an index of seizure propensity." | 3.74 | Seizure susceptibility alteration following reversible cholestasis in mice: Modulation by opioids and nitric oxide. ( Dehpour, AR; Doratotaj, B; Gholipour, T; Honar, H; Jannati, A; Nik, HH; Noorian, AR; Riazi, K; Shariftabrizi, A, 2008) |
| "Based on these findings, both opioid receptors and nitric oxide may be involved in the dramatic increase in pentylenetetrazole-induced seizure threshold in cholestasis." | 3.71 | The additive effect of opioids and nitric oxide in increasing pentylenetetrazole-induced seizure threshold in cholestatic mice. ( Dehpour, AR; Homayoun, H; Sayyah, M, 2002) |
| "Cholestasis decreased seizure activity and increased lag phase before seizure and both effects were decreased by dithizone injection." | 1.35 | Effect of metal chelating agents on pentylenetetrazole-induced seizure threshold in cholestatic mice. ( Dehpour, AR; Ghasemi, M; Kebriaeezadeh, A; Mehr, SE; Nouri, M; Rayatzadeh, H, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| D'Mello, C | 1 |
| Riazi, K | 2 |
| Le, T | 1 |
| Stevens, KM | 1 |
| Wang, A | 1 |
| McKay, DM | 1 |
| Pittman, QJ | 1 |
| Swain, MG | 1 |
| Rayatzadeh, H | 1 |
| Nouri, M | 1 |
| Ghasemi, M | 2 |
| Kebriaeezadeh, A | 1 |
| Mehr, SE | 1 |
| Dehpour, AR | 4 |
| Shafaroodi, H | 1 |
| Gholipour, T | 1 |
| Noorian, AR | 1 |
| Jannati, A | 1 |
| Honar, H | 1 |
| Doratotaj, B | 1 |
| Nik, HH | 1 |
| Shariftabrizi, A | 1 |
| Homayoun, H | 1 |
| Sayyah, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Brain Activity and Oxygenation Using Near-infrared Spectroscopy (NIRS) in Inflammatory Bowel Disease (IBD) Patients[NCT04733456] | 40 participants (Anticipated) | Observational | 2021-04-26 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for pentylenetetrazole and Bile Duct Obstruction
| Article | Year |
|---|---|
P-selectin-mediated monocyte-cerebral endothelium adhesive interactions link peripheral organ inflammation to sickness behaviors.
Topics: Alanine Transaminase; Animals; Cell Adhesion; Cerebral Cortex; Cholestasis; Colitis; Cytokines; Dini | 2013 |
Effect of metal chelating agents on pentylenetetrazole-induced seizure threshold in cholestatic mice.
Topics: Animals; Bile Ducts; Chelating Agents; Cholestasis; Disease Models, Animal; Dithizone; Ditiocarb; Do | 2009 |
Elevation of pentylenetetrazole-induced seizure threshold in cholestatic mice: interaction between opioid and cannabinoid systems.
Topics: Animals; Anticonvulsants; Bile Ducts; Cannabinoid Receptor Modulators; Cholestasis; Disease Models, | 2008 |
Seizure susceptibility alteration following reversible cholestasis in mice: Modulation by opioids and nitric oxide.
Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Bilirubin; Biomarkers; Cholestasis; Corn Oi | 2008 |
The additive effect of opioids and nitric oxide in increasing pentylenetetrazole-induced seizure threshold in cholestatic mice.
Topics: Animals; Cholestasis; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Male; M | 2002 |